Mezim contraindications for use. Composition of Mezim: digestive enzymes in the treatment of the stomach

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Registration number : P N014681/01 dated 03/24/09

Trade proprietary name : Mezim® forte 10000

International non-proprietary name
or group name: Pancreatin

Dosage form: enteric-coated tablets

Composition per tablet
Nucleus
Active substance: Pancreatin powder -137.5 mg
with minimal enzymatic activity:
lipases 10000 IU Ph. Eur.
amylase 7500 IU Ph. Eur.
protease 375 U Ph. Eur.

Excipients: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate; shell: hypromellose (~5 mPa s), methacrylic acid and ethyl acrylate copolymer (1:1) dispersion 30% (dry weight), triethyl citrate, titanium dioxide (E 171), talc, simethicone emulsion 30% (dry weight), macrogol 6000 , sodium carmellose (~ 30 mPa s), polysorbate 80, azorubine varnish (E 122), sodium hydroxide.

Description: pink round enteric-coated tablets, with biconvex surfaces, with chamfers, brown blotches are possible at the break.

Pharmacotherapeutic group: Digestive enzyme agent
ATX code: A09AA02.

Pharmacological properties
Pharmacodynamics. An enzyme preparation that improves digestion.
Pancreatin is a powder from porcine pancreas, which, along with exocrine pancreatic enzymes - lipase, amylase, protease, trypsin and chymotrypsin, also contains other enzymes.

Pancreatic enzymes, which are part of the drug, facilitate the breakdown of proteins, fats and carbohydrates, which leads to their more complete absorption in small intestine. Trypsin suppresses stimulated secretion of the pancreas, providing an analgesic effect. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.

Pharmacokinetics. Tablets Mezim ® forte 10000 are coated with an acid-resistant coating that does not dissolve under the action of of hydrochloric acid stomach and thereby protects the enzymes contained in the preparation from inactivation. The dissolution of the shell and the release of enzymes occurs at a pH value close to neutral or slightly alkaline.

Indications for use

- replacement therapy for exocrine pancreatic insufficiency (including chronic pancreatitis, cystic fibrosis);
- chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder;
- conditions after resection or irradiation of the gastrointestinal tract, accompanied by impaired digestion of food, flatulence, diarrhea (as part of combination therapy);
- disorder of the gastrointestinal tract of a functional nature (with intestinal infectious diseases, irritable bowel syndrome, etc.);
- to improve the digestion of food in patients with normal function Gastrointestinal tract in case of nutritional errors;
- preparation for x-ray and ultrasound research bodies abdominal cavity.

Contraindications

- acute pancreatitis;

- exacerbation of chronic pancreatitis;
- hypersensitivity to pancreatin or other components of the drug;
- hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
- childhood up to 3 years (indivisible dosage form).

Use during pregnancy and lactation

Due to the lack of sufficient data on the use of pancreatic enzymes in humans during pregnancy and lactation, the use of Mezim® forte 10000 is possible only if the expected benefit to the mother exceeds possible risk for the fetus or child.

Dosage and administration

The dose of Mezim ® forte 10000 is set individually depending on the severity of the disease and the composition of the food.

Unless otherwise stated, average single dose for adults is 2-4 Mezim ® forte 10000 tablets per meal. It is recommended to take half or a third of a single dose at the beginning of a meal, and the rest during it. The drug is taken orally, without chewing and drinking enough liquids.

It is possible to increase the dose, which should be carried out only under the supervision of a physician, focusing on the weakening of symptoms (for example, steatorrhea, abdominal pain).

Maximum daily dose- 15000-20000 IU Ph. Eur. lipases / kg body weight.

For children, the dosage regimen is set by the doctor, depending on the severity of the disease and the composition of the food at the rate of 500-1000 IU Ph. Eur. lipases/kg of the child's body weight for each meal.

The duration of treatment can vary from several days (in case of indigestion, errors in the diet) to several months and even years (if necessary, constant replacement therapy).

Side effect

No development detected side effects or complications even with prolonged and regular use of Mezim® forte 10000 in patients with impaired pancreatic function.

In some cases, after taking pancreatin, it is possible to develop allergic reactions, rarely - diarrhea or constipation, nausea, discomfort in epigastric region. AT isolated cases in patients with cystic fibrosis, long-term use high doses drug may develop hyperuricosuria (increased levels of uric acid in plasma), strictures may form in the ileocecal region and the ascending colon.

Overdose

There are no data on cases of overdose and intoxication with the drug.
Possible: hyperuricosuria, hyperuricemia, constipation in children.
Treatment: drug withdrawal, symptomatic therapy.

Interaction with other drugs
When taking drugs containing pancreatin, a decrease in absorption is possible. folic acid. The effect of hypoglycemic drugs (acarbose, miglitol) may decrease with simultaneous reception with pancreatin.
With the simultaneous use of pancreatin with iron preparations, a decrease in the absorption of the latter is possible. Simultaneous use antacids containing calcium carbonate and / or magnesium hydroxide, may lead to a decrease in the effectiveness of the drug.

special instructions
At acute pancreatitis or exacerbation of chronic pancreatitis (at the stage of attenuation of exacerbation), during recovery diet food, it is advisable to prescribe Mezim forte 10000 against the background of ongoing or remaining insufficiency of pancreatic function.
Mezim ® forte 10000, taking into account the solid indivisible dosage form is contraindicated in children under 3 years of age.

Mezim is an enzyme preparation that is used to replenish the lack of pancreatic enzymes. This drug is used as part of complex therapy.

People are wondering, but what does Mezim help from? From most diseases associated with the gastrointestinal tract.

It is prescribed to reduce the load on the pancreas. Mezim, indications for use: exacerbation of pancreatitis, ulcer, enteritis, intestinal infections, dysbacteriosis, dyspeptic disorders and in preparation for x-ray and ultrasound examinations.

Capsules should be taken orally with plenty of water. Children after three years and adults, it is recommended to take 1-2 tablets with meals. During the treatment period, 2-3 tablets are prescribed. The term for taking medications is prescribed by the doctor on an individual basis.

Mezim forte 10000: instructions for use. With heaviness and bloating, patients are advised to drink 1-2 capsules, but remember that the dosage may depend on the disease. For substitution treatment prescribe 2-4 tablets. It is very important to follow the rules of application.

Important properties, Mezim forte. This medicine breaks down proteins, carbohydrates and fats into amino acids, the main substance of this medication is pancreatin. It has a proteolytic, amylolytic, lipolytic action. Mezim forte has an analgesic effect, thanks to an enzyme called trypsin.

Contraindications of the drug Mezim forte

• Various exacerbations of pancreatitis
• Strong sensitivity to the drug
• Allergy to lactose
• Hives
• Age up to 3 years
• High levels of uric acid in the blood

Side effects, instructions: allergies, stool disorders, nausea, abdominal pain, the appearance of hyperuricosuria.

Interaction with other drugs. Interaction with iron preparations or those containing calcium carbonate and magnesium may lead to a decrease in the effectiveness of treatment.

Terms of storage and conditions. Keep out of the reach of children at a temperature not exceeding 30 C, the total shelf life is three years.

Compound of this preparation: the main part of the enzymes is of animal origin, they are obtained from the pancreas of pigs. One tablet contains:

• Lipase (contained in pancreatic juice, corrodes food fats)
• Amylase (produced in the salivary glands and pancreas, breaks down starch + carbohydrates in the intestine, excreted with urine)
• Protease (these are proteins that cleave amide bonds between different compounds)

Also included are excipients:

• Talc.
• Special varnish.
• Hypromellose.
• Semiticon emulsion.
• Titanium dioxide.
• Macrogol.

Pharmakinetics.

Mezim forte tablets are coated with an acid-resistant coating that does not dissolve due to the action of hydrochloric acid in the stomach, thereby preserving the substances that are in the preparation. Mezim begins to act, as efficiently as possible, half an hour after taking the drug.

Mezim, analogues are cheaper

Use during pregnancy. The effect of this drug on pregnant women is little studied. You can safely take this drug, but not forgetting the existence individual intolerance certain substances in humans.

Application and indication for children. This drug is prescribed to children as an addition to the course of treatment for diseases of the gastrointestinal tract. When abused harmful products nutrition, overeating and poisoning, you can drink just one tablet. In most cases, the drug is prescribed for children with pancreatitis, which develops against the background of diseases of the biliary tract.

The main diseases for which this drug is prescribed:

• Intestinal infections.
• Cystic fibrosis.
• Chair disorder.
• After certain stomach operations.

Mezim or Normoenzyme?

Preparations Mezim and Normoenzym are similar in composition. In the first option, there are many more pluses. Normoenzyme is contraindicated in liver diseases, has many side effects and should be taken with caution during pregnancy. In contrast, Mezim is considered safe medicine which most doctors prescribe.

Benefits: An old and reliable drug that never fails.

Disadvantages: not found.

It takes two pills and I am saved from severe stomach pains and again, as good as new. The only thing that doesn't suit me is the price, it could be lower.

I always take these pills after the holidays, it helps a lot after overeating, much better than its counterparts, the drug pleases with an affordable price.

Conclusion.

In some reviews about Mezim, they usually write that this drug is well tolerated by the body and rarely causes side effects. Note the speed and effectiveness of this medicine.

Many patients felt improvement from the first minutes of taking it.

In other reviews, most people argue about which is better: Mezim or Festal, but it’s clear that Mezim forte is better, because it contains more pancreatin, and Festal is just an analogue. The drug is quite expensive, but this does not negate its popularity and effectiveness in light gastrointestinal diseases, it helps with most unpleasant consequences! If you want to check the quality of Mezim forte and its authenticity, pay attention to the registration certificate number, barcode, packaging that can be easily opened with a conventional valve, the list and composition of enzymes on reverse side packaging, a real blister made of matte, not shiny foil. Do not forget to help other people and leave your feedback about this medicine!

The drug Mezim Forte is used to ensure better digestibility certain types products containing different amounts of fats, proteins and carbohydrates. Mezim is enzymatic species medicines designed to provide healthy digestion. The product is available in the form of tablets and is dispensed from pharmacies freely, thanks to its natural and safe composition.

Photo: Instructions for use Mezim Forte

The dosage of the agent should be selected individually (the dosage of the agent is also taken into account - 10,000 or 20,000). It depends primarily on the level of deficiency of pancreatic enzymes in the human duodenum. If Mezim Forte is used as aid when used a large number fatty, fried and difficult to digest food, doctors recommend using 1-2 tablets.

For digestive disorders, the recommended dose is 2-4 tablets. In case of urgent need, the dose is increased. It is worth increasing the number of tablets taken only under the supervision of a doctor, as stated in the instructions. Usually, an increase in the number of pills taken is due to such symptoms:

• nausea;
• indigestion;
• epigastric pain.

It is important to take into account that the daily dose of lipase cannot exceed 15-20 thousand units E.F. per 1 kg. adult body weight.

You need to take the tablets while eating. However, they must be drunk. large quantity water without chewing and swallowing whole. The duration of treatment is determined by the doctor individually for each individual patient.

Mezim Forte for children under 12 years of age is prescribed in a daily dose that will normalize the stool. This dose should not exceed 1500 IU E.F. lipases per kilogram of body weight.

The full course of therapy can be a single dose of the drug or Mezim Forte for 2-3 days. Therapy can last for several months or even years. In the latter case, such a long course of treatment is necessary as a replacement therapy for serious pathologies or resection of the stomach.

Compound

Tablets Mezim Forte

Mezim Forte is available in the form of tablets (droplets) of pink color and flat shape. The pills are different slight smell pancreatin. One package contains 20 or 80 tablets of the product.

The preparation contains the following active ingredients:

• pancreatin - 140 mg;
• lipase - 3500 IU;
• amylase - 4200 IU;
• proteases - 250 units.

Among the fillers are the following components:

• aerosil;
• sodium carboxymethyl starch type A;
• magnesium stearate.

The dragee shell consists of several components that form a film coating:

• hypromellose;
• talc;
• azorubine varnish;
• emulsion of simethicone 30%;
• polyacrylate dispersion 30%;
• macrogol 6000;
• titanium dioxide.

Indications

Mezim Forte is indicated for use as a therapeutic agent and prevention of diseases and dysfunction of the gastrointestinal tract during overeating. Also among the indications for use it is worth highlighting:

junk food, overeating

• organ pathology digestive system caused by dystrophic and inflammatory processes in tissues;
• dysfunctional disorders of the gastrointestinal tract resulting from chemotherapy, surgical interventions and characterized by stool disorder, digestion, bloating, epigastric pain;
• pronounced hyposecretion of pancreatic enzymes, causing functional disorders in the work of the gastrointestinal tract;
• chronic diseases of the digestive system, including hepatitis, chronic pancreatitis, gastritis and enterocolitis;
• functional acceleration of the passage of food through the intestines;
• malnutrition (overeating, eating incompatible products, as well as dishes that can cause bloating, excessive gas formation and fermentation processes).

Mezim is also indicated for use before ultrasound or radiography of the abdominal organs as an auxiliary, preparatory agent.

Contraindications

bowel problems

The drug should not be used if acute course pancreatitis. Also, in no case should you use Mezim Forte during an exacerbation of chronic pancreatitis.

Treatment of children with Mezim without a doctor's appointment is not carried out. Seeing a doctor is essential to determine required dose drug for a particular child.

Reception is not possible with hypersensitivity to any component of the tool. If an allergic reaction to the drug is detected, the drug should be stopped immediately and consult a doctor for advice on symptomatic therapy states.

The drug is not taken with intestinal obstruction obstructive type. It is also a contraindication if the patient has obstructive jaundice. In case of inflammatory processes in the liver tissues, the drug can be taken only after consulting a doctor.

Side effects

The frequency of side effects from taking Mezim Forte is unknown.

From the side of cardio-vascular system tachycardia may occur.

From the side immune system possible hypersensitivity reactions, including skin rashes, lacrimation, sneezing, bronchospasm.

From the gastrointestinal tract, a few side effects may occur, the frequency of which has also not been studied. Thus, with cystic fibrosis, patients may suffer from the formation of constrictions in the ileocecal region and in colon. On the part of the digestive system, there may also be allergic manifestations including loose stools, abdominal pain, frequent diarrhea and nausea.

Photo: Abdominal pain

From the side skin possible occurrence angioedema, urticaria, hyperemia, itching and redness.

From the side genitourinary system patients with cystic fibrosis may have increased excretion uric acid in the urine. In this case, the amount of uric acid must be controlled.

Among the general disturbances, a sharp sensation of intense heat, low work capacity and weakness in the body are possible.

Use during pregnancy and lactation

The use of Mezim during pregnancy and lactation has been studied scientifically, but this did not give proper safety results. Thus, taking the drug is allowed only if the benefit from its use outweighs the risk to the fetus. It is possible to use the drug for pregnant and lactating mothers only after consulting a doctor and a thorough examination.

The use of Mezim forte with other drugs and alcohol

When using Mezim Forte simultaneously with other drugs containing pancreatin, patients may experience a deterioration in the absorption of folic acid. At the same time, patients can be recommended additional sources of obtaining this missing component.

When using Mezim Forte simultaneously with antacids, there may be a decrease or complete elimination therapeutic effect Mezima. This applies to taking the drug simultaneously with those antacids that contain magnesium hydroxide or calcium carbonate in their composition.

There is no data on the incompatibility of Mezim Forte and alcohol. At the same time, it should be taken into account that simultaneous use strong drinks with the drug can lead to inhibition of the effects of the latter.

Overdose

In case of an overdose of the drug, patients may experience a significant increase in the side effects of the drug, including:

1. Narrowing of the ileocecal region of the intestine (typical for patients with cystic fibrosis).
2. Hyperuricemia.
3. Hyperuricosuria.

Therapy of these conditions in case of overdose is symptomatic, that is, aimed at eliminating the main signs that disturb the patient.

Overdose in patients younger age may be observed for a long time.

Shelf life and storage conditions

The shelf life of the drug is 3 years from the date of release of the drug. It is necessary to store Mezim Forte in original packaging. The storage location must be dark and dry. When exposed high temperatures on a dragee (above 30 ° C), the properties of the product may be distorted.

The drug should be kept out of the reach of animals and children. In case of accidental use of a large number of pills by a child or an adult, you need to go to the hospital.

Price

What is the price?

The price of Mezim Forte in Moscow ranges from 300 rubles. The cost depends on the number of tablets in the package and pharmacy network where the product is purchased. In general, the price of the drug in the cities of Russia is as follows:

1. Moscow - from 83 to 298 rubles.
2. St. Petersburg - from 72 to 263 rubles.
3. Yekaterinburg - from 43 to 289 rubles.
4. Novosibirsk - from 64 to 302 rubles.
5. Nizhny Novgorod - from 59 to 273 rubles.
6. Kazan - from 49 to 295 rubles.
7. Rostov-on-Don - from 78 to 260 rubles.

The cost of the drug can be significantly lower if you purchase it in an online pharmacy. It should be borne in mind that this carries certain risks, since the tool may turn out to be a fake.

Analogues

The most common and well-known substitute for Mezim Forte is Pancreatin. Although this preparation also contains enzymes, the amount active substance in Pancreatin is much less than in the original remedy.

The differences between Pancreatin and Mezim Forte are also in the manufacturer. Mezim is made in Germany, Pancreatin - domestic drug. Many gastroenterologists point out that Mezim should be taken to treat digestive problems and gastrointestinal diseases. At the same time, Pancreatin is more suitable as a means of prevention.

Photo: Mezim or Pancreatin? Analogues

In addition to Pancreatin, there are a number of other means representing analogues of Mezim Forte. These drugs are also quite often used as substitutes for the original remedy.

1. Creon. This drug is manufactured in Germany. Gelatin capsules contain natural pancreatin. The cost of the drug varies 300 rubles.
2. Ermital. It is also produced in Germany and contains pancreatin as the main active ingredient. The price of the tool is 219 rubles.
3. Micrasim. This drug is produced in Russia and is a direct analogue of Mezim. The drug costs about 246 rubles.
4. Panzinorm. strong drug made in Germany. This drug contains not only pancreatin, but also a number of additional components, including bile extract and mucous membrane extract cattle. Medium the price of the drug is 171 rubles.
5. Solizim. The drug is rather weak, even in comparison with Pancreatin. The tool breaks down only fats, while ignoring proteins and carbohydrates. The price is about 1020 rubles.
6. Festal. This Indian equivalent of mezim has been used by humans for over 2 decades. The product contains not only pancreatin, but also an extract of bovine bile. The price of the drug is cheaper and fluctuates from 59 rubles.
7. Enzistal. Produced in India and is the same Festal. There are practically no differences between these drugs. The average cost of funds - 88 rubles.

Important! It should be understood that taking these drugs without the advice of a doctor is unsafe. The opinion that preparations containing enzymes are absolutely safe is erroneous.

Photo: Mezim forte 10000, reviews

A tablet preparation or simply tablets Mezim forte is a drug that belongs to the group of enzyme preparations and is prescribed to patients for the purpose of prevention or for the treatment of a number of disorders in the digestive system.

Mezim forte is a drug that improves the digestion of proteins, fats and. Also, the drug compensates for pancreatic insufficiency, namely its exocrine function

Form of release of the drug and its composition

Preparations Mezim forte 10000 (the Latin name is also used - Mezym® forte 10000) and Mezim forte 20000 - on this moment are produced in the form of tablets with a specific odor and intended for oral use. They are equipped film sheath, which has pink color. Tablets are packed in ordinary pharmacy blisters of 20 pcs. and in a cardboard box with enclosed instructions with detailed description drug and instructions for its use.

Each tablet contains a balanced enzyme complex of amylase, lipase and protease. The content of enzymes in the preparation corresponds to their content in the body with a normally functioning gastrointestinal tract, that is, it is a substitute for these enzymes. In addition, each tablet contains a number of auxiliary components-additives.

Pharmacological action of the drug

Mezim forte 10000 (20000) is a combined enzyme preparation that successfully compensates for insufficient efficient work damaged pancreas, as well as the duodenum.

Often on the review forums they ask the question: what is the difference between the compositions of Pancreatin and Mezim? What's better? And can one drug be replaced by another? The fact is that their only significant difference, in theory, lies in their cost. In fact, the question "Mezim forte or Pancreatin" is not so simple, although these are, in fact, analogues. Mezim forte can indeed be replaced with Pancreatin in most cases. Both of these products contain important enzymes of the digestive system - amylase, protease and lipase, which facilitate the process of digestion of food in the body with dysfunction of the digestive organs, helping it break down and absorb fats, proteins and carbohydrates, thereby further reducing the load on the already " suffering" damaged pancreas. However, a number of important factors should be taken into account, and in no case should one drug be replaced by another without the consent of your doctor - despite the fact that the price of Pancreatin is much lower.

Note! There is an opinion, which, by the way, is not without foundation, that medicinal product Mezim Forte is still characterized by a higher degree of purification, which makes it more suitable for children. Mezim is prescribed more often than pancreatin, not only for use in the treatment of younger patients, but also when the patient has a history of severe allergic reactions or the so-called allergic status. Mezim forte during pregnancy also often becomes the drug of choice, which is preferred over pancreatin, which is also due to special condition the immune system of the expectant mother.

When it is shown

Mezim forte tablets are usually prescribed to patients with such pathological conditions:

1. Chronic diseases of the pancreatic tissues, directly related to the insufficiency of the production of the above enzymes;
2. Chronic diseases of the stomach inflammatory nature, as well as diseases of the gallbladder and intestines, due to a violation of the normal physiological digestion of food;

Medicine can be used when chronic forms inflammatory processes stomach and intestines. The drug is also used for flatulence

1. Unbalanced and/or monotonous food, the predominance of the patient in the diet of food of low humidity and dishes of the so-called "fast food";

The drug Mezim forte can also be prescribed to some patients before preparing them for x-ray examination a number of abdominal organs.

Contraindications

Before you start using the drug, you should definitely carefully study the instructions enclosed in the box, since the use of Mezim forte has certain limitations and a number of contraindications:

1. Individual reaction to any components that make up this drug;
2. Phase of exacerbation of chronic or other chronic diseases organs of the digestive tract;
3. Acute pancreatitis in any form.

Application and required dosage

The daily dose of the considered enzyme preparation is established by the attending physician individually - according to the results of the patient's tests and data from other conducted diagnostic studies in addition, the dose may vary depending on the characteristics of the diagnosis and the individual characteristics of the organism of each patient.

According to general instruction, adult patients are usually prescribed one or two tablets of the drug, which is 10,000-20,000 IU of lipase - immediately before meals or during meals three times a day. Tablets must be swallowed immediately, in no case chewed.

The drug is prescribed to younger patients (up to 12 years old) strictly according to indications and always under the constant supervision of a doctor by prescription.

Important! For children, the daily dose indicated in the prescription and medical card child, is always set individually based on a number of indicators: body weight, established diagnosis and the degree of manifestation of violations. Be sure to strictly follow all the instructions of the doctor, without underestimating or overestimating the amount of the drug recommended by the specialist.

Can Mezim be taken during pregnancy?

Mezim forte is prescribed for pregnant women if additional relief of digestion is necessary. The drug is well tolerated and does not require the patient to interrupt lactation when breastfeeding. However, before starting the course, you should consult with your doctor.

Side effect

In general, the drug is well tolerated, however, with individual sensitivity to its components, a number of individuals may experience:

1. Increased gas formation in the intestines;
2. Pain in the stomach;
3. Feeling of hunger, regardless of whether the patient took food;
4. Disorders of the stool;
5. Nausea;
6. Occasionally, allergic-like conditions can be observed - redness of the skin, itching.

Overdose

There have been no cases of overdose in patients treated with Mezim forte, however, with its uncontrolled use in excessive doses, subsequent development is possible. negative phenomena from the gastrointestinal tract, namely, nausea, pain in the stomach, vomiting, stool disorders.

What can not be combined with

1. The drug Mezim Forte is categorically not recommended for use in combination with taking iron supplements, since such a combination can eventually lead to a significant violation of iron absorption in thin departments intestines and to the subsequent decrease in therapeutic effect.
2. Simultaneous treatment with antacids, as well as enterosorbents - reduces the effect of the use of Mezim forte, for this reason it is not recommended to combine the drugs of these groups or, if necessary, their joint use to maintain the required time interval.

What to do during treatment

If you have been prescribed Mezim forte, then the effect of its use will be higher when the patient follows a diet that excludes fatty, fried, spicy food, as well as seasonings, alcohol and spices.

Smoking should also be excluded as a factor provoking an increase in symptoms and an exacerbation of the disease.

Is it prescribed to very young children

In patients under 12 years of age, this medicinal product should be administered with caution due to not enough clinical experience, and the dose is determined individually by the doctor.

Important! Mezim forte is prescribed for children in smaller doses, which are determined by the attending physician individually - not only depending on the condition, but also on the age and body weight of the child.

What does it replace

similar in principle therapeutic action drugs:

1. Creon;
2. Enzistal tablets;
3. Penzital tablets;
4. Pancreatin;
5. Festal tablets.

Advice! Replacement of the drug must be agreed with the attending physician!

Do you need a prescription

Mezim forte is dispensed in pharmacies, as a rule, without a prescription. It should be stored in the original cardboard box in a cool and dark place - so that the drug is inaccessible to children. Overheating of the blister should be avoided, as well as direct contact with the packaging. sun rays. The medicine in such conditions is stored for 2 years.

Note! Mezim forte does not affect the work of the central nervous system, absolutely not reducing the speed of the patient's normal psychomotor reactions. Even with enough long-term treatment this drug cannot cause addiction in the patient.

How much does it cost

In St. Petersburg, Mezim forte can be purchased at any pharmacy chain at average cost 280 rub.

It is interesting! By the way, the average St. Petersburg patient, according to independent studies, still prefers Mezim to its cheaper analogues.

Familiar to almost everyone. Unpleasant sensations in the abdomen are most often observed after eating. The lack of enzymes necessary for the digestion process can be compensated by special medical preparations. Instructions for use "Mezim forte 10000" recommends using the medicine for violations of the digestive system.

What is a remedy?

The stomach does not always cope with its direct duties. The role of the main assistants in this case is played by medicines, which contain enzymes - biological catalysts that accelerate chemical reactions in the body. The most popular enzyme preparation is "Mezim forte 10000" produced by the German pharmaceutical company Berlin-Chemie. The main effect of the drug is aimed at normalizing the process of digestion of food and the absorption of nutrients.

With a lack of digestive enzymes, over time, the development of diseases of the liver, pancreas, and gallbladder is observed. After establishing the cause pathological condition a specialist may prescribe the drug "Mezim forte". The enzymes contained in the product contribute to the absorption of fats, proteins and carbohydrates necessary for full-fledged work all organs and systems. Depending on the patient's condition, a certain dosage is selected. active substances("Mezim forte 10000" and "Mezim forte").

What helps?

The drug has an auxiliary effect and contributes to the production of the amount of enzymes necessary for the digestion of food by the pancreas. According to official instructions, "Mezim forte" is taken according to the following indications:

• Violation of the function of the (external) pancreas. This can be caused by diseases such as cystic fibrosis (a lesion of chronic pancreatitis.
• inflammatory processes in gastrointestinal tract(acute and chronic form).
• Digestive disorders caused by surgery exposure of the digestive tract, kidneys, liver, gallbladder.
• Infectious lesion of the intestine, which provoked prolonged diarrhea.
• Eating disorders (overeating, eating unfamiliar and hard to digest food).
• Chronic pathologies of the liver.
• Preparation before examination of the stomach, intestines (endoscopy, X-ray, ultrasound).

The composition of the drug

The main component of the product is pancreatin - a substance in the form of a powder made from the pancreas of porcine glands. The minimum lipatic activity of pancreatin is 3500 IU. Instructions for use "Mezim forte 10000" indicates that this enzyme contains substances necessary for normal digestion:

1. Lipase - refers to water-soluble enzymes and is an integral component of pancreatic juice. Promotes the absorption of fats. One tablet contains 10,000 units.
2. Protease - is responsible for the normalization of microflora in the digestive tract. The action of the substance is directed to good assimilation proteins and cleavage of the peptide bond between amino acids. One tablet contains 375 IU.
3. Amylase - necessary for the proper breakdown and absorption of carbohydrates. This enzyme was first discovered by scientists. Produced by the salivary and pancreas. One tablet contains 7500 IU.

Mode of application

It is necessary to understand that you can get rid of digestive problems only by determining true reason pathological condition. In case of violation of external digestion, doctors most often recommend taking "Mezim forte". What does the drug help? First of all, it will improve the digestion of food and relieve unpleasant discomfort and heaviness after eating.

Tablets should be taken with meals or immediately after a meal. Chewing the medicine is prohibited! Tablets should be washed down with a large amount of alkaline liquid - mineral water, juice.

Dosage

Before taking Mezim Forte, you should get expert advice on the optimal dosage, which is calculated based on the patient's condition. If the enzyme preparation must be taken constantly, as a replacement therapy, only the attending physician can adjust the daily dose.

Usually a single dose is 2-4 tablets per meal. Depending on the type of product and the amount of active substances in the composition, the dosage may vary. To eliminate temporary digestive problems caused by errors in the diet, it is prescribed minimum dose substances in the composition of "Mezim forte". The price of the drug also depends on the dosage and the number of tablets in the package. The minimum cost of the drug is about 75 rubles. (20 tablets).

Is an enzyme preparation given to children?

AT pediatric practice often there are cases when substitution therapy is indispensable. The enzyme preparation "Mezim forte" for children is prescribed if it is necessary to establish and improve the digestive process. Pancreatic enzymes in the tablets help to cope with increased gas formation, eliminate discomfort after eating. Also, the drug is prescribed after surgical interventions, with intestinal infections, diarrhea.

According to the instructions, the enzymatic agent is contraindicated for use in children under 3 years of age. The daily dose should not exceed 1500 IU per 1 kg of the child's weight. Usually, before eating, you should give the baby a third of the tablet.

For children from 12 years of age, the dose may increase to 15,000 IU. Doctors recommend that you do not use the medicine for the treatment of children on your own and first consult a pediatrician.

Causes of Enzyme Deficiency

Subject to correct mode food, consumption useful products body is capable of producing required amount enzymes. The lack of these substances can develop against the background of the following factors:

• Constant overeating.
• Eating insufficiently processed food.
• The presence of inflammatory processes in the digestive organs.
• Problems with metabolism.
• Poor chewing of food.
• Eating foods high in fat, protein and carbohydrates.

Also, deterioration of the condition is observed with intestinal dysbacteriosis, congenital diseases organs of the gastrointestinal tract. To eliminate the problem associated with enzyme deficiency, the drug "Mezim forte" will help. The dosage may vary depending on the diagnosis. The maximum daily dose is not more than 20,000 IU per day.

Contraindications for use

Enzyme drug "Mezim forte" has a number of contraindications regarding treatment with this drug:

• pancreatitis in acute phase or exacerbation of the chronic form.
• Hypersensitivity to the components in the composition of the tablets.
• Intolerance to active substances.
• Age up to 3 years.
• Lactose intolerance.
• Syndrome of glucose-galactose maldsorption.

During pregnancy and lactation, an enzyme agent can be prescribed to improve digestion. Instructions for use "Mezim forte 10000" says that there are no data on the use of the drug for this category of patients. At the same time, doctors often prescribe the drug for women in a position where periodically there is a feeling of overeating, heaviness in the epigastric region. The drug should be used with caution and only in emergency cases. You should first consult with your gynecologist.

Side effects

Development side effects caused by taking an enzyme preparation is extremely rare. Some negative reactions can only develop if long-term therapy drug, allergies to components or exceeding the recommended daily dose.

Side effects are expressed in the form of rashes, itching, nausea, indigestion (constipation, diarrhea). An increase in the values ​​of uric acid in the blood is observed during long-term treatment with Mezim Forte.

Price and reviews

The cost of the drug depends on the number of tablets in the package and dosage. You can buy "Mezim forte" in pharmacy kiosk for 75-90 rubles. (pack of 20 tablets). "Mezim forte 10000" will cost the patient 200-250 rubles. (20 tablets).

Instructions for use "Mezim forte 10000" positions the tool as the most effective and safe of this category of pharmaceutical products. Numerous positive recommendations from patients confirm the presence of a pronounced therapeutic effect and improvement in the condition as early as 20 minutes after taking the tablets. Subject to the dosage and recommendations for treatment, the drug does not cause side effects and is well tolerated by the body.