Tanakan improves the vascular and nervous systems of the body. Tanakan tablets - instructions for use Tanakan instructions for use tablets

Tanakan is a drug with a positive effect on the nervous and vascular systems.

The drug is made on a plant basis. A course of therapy should be started only after discussion with a doctor.

And it is useful to carefully read the description of the medicine.

Characteristics of the drug according to the instructions

Tanakan has angioprotective properties. It is developed on the basis of an extract of the leaves of a tree called Ginkgo biloba biloba.

You can find out how the medicine works in reviews written by patients. They are given in the last part of the article.

Release form and composition

The drug is prepared in the form of:

Tablets 40 mg, film-coated, red-brick color. The tablets are round, biconvex with a break. A blister made of aluminum foil and PVC contains 15 tablets. A cardboard pack contains 2 or 6 blisters. That is, the package contains 30 or 90 tablets.
The solution for internal use is brown-orange in color with a specific odor. Packaging: dark glass bottle with a plastic screw cap. A dispensing pipette with a capacity of 1 ml is attached.

The active ingredients of Tanakana tablets are:

40 mg ginkgo biloba leaf extract,
24% flavonoid glycosides,
6% terpenes,
bilobalids,
ginkgolides A, C, B,
proanthocyanidins,
organic acids.

The fillers in tablets are (in mg):

82.5 lactose,
50 monocrystalline cellulose,
37 maize starch,
28 colloidal anhydrous silica,
1.25 magnesium stearate,
1.5 polyethylene glycol 400,
1.5 polyethylene glycol 600,
6 methylhydroxypropylcellulose,
1.025 titanium dioxide,
0.65 red iron dioxide.

The solution contains the same active substances. The fillers are (in ml):

0.5 sodium saccharin,
0.75 soluble orange essence,
0.75 soluble lemon essence,
59 ethyl alcohol,
100 purified water.

Storage method

The medicine should be kept in a place where children do not have access. The recommended temperature is less than 25°C.

The shelf life is three years. After its expiration, the drug cannot be used.

About beneficial properties

This medicine has the following positive qualities:

improves the supply of glucose and oxygen to the brain,
normalizes the tone of veins and arteries,
activates microcirculation,
thins the blood
inhibits platelet activation,
improves metabolic processes,
counteracts the formation of free radicals,
fights swelling in the brain and at the periphery level.

As a result, there is an improvement in cerebral circulation, an increase in vascular tone of the entire body, including the smallest vessels of the brain.

Bilobalides and ginkgolides have high bioavailability (80-90%). The maximum concentration is reached within an hour or two after administration. The main route of elimination is through the kidneys.

In what cases is the drug prescribed?

Indications for the use of Tanakan include the following conditions:

cerebrovascular accidents of various nature (excluding senile dementia and Alzheimer's disease);
intermittent claudication with obliterating chronic arteriopathy of the legs;
hearing impairment, ringing in the ears, dizziness and coordination disorders, mainly of vascular origin;
visual impairment due to vascular problems, decreased visual acuity;
Raynaud's syndrome and disease;
after a stroke and traumatic brain injury (with a decrease in intellectual abilities and memory, sleep disorders);
asthenia due to injuries or depression of a psychogenic nature.

Video

Video instructions for using the drug:

Contraindications

There is a list of contraindications for the use of Tanakan:

high sensitivity to the composition or its elements,
exacerbation of erosive gastritis,
acute condition of peptic ulcer,
impaired cerebral circulation in the acute stage,
low degree of blood clotting,
attack of myocardial infarction,
state of pregnancy and lactation (due to lack of verified clinical data),
age under 18 years.

Due to the presence of lactose in tablets, the drug is not prescribed for:

congenital galactosemia,
galactose or glucose malabsorption syndrome,
lactose deficiency or lactose intolerance.

The presence of ethyl alcohol in the solution serves as an obstacle to its intake in the following cases:

alcoholism,
liver diseases,
brain diseases,
traumatic brain injury.

Despite the fact that the medicine is contraindicated before the age of 18, sometimes it is prescribed even to infants with pathology of cerebral circulation, high intracranial pressure or dysfunction of the autonomic system.

Use in these cases should be strictly according to individual indications and under the systematic supervision of a physician.

Side effects

After taking Tanakan, side effects may appear in the form of:

allergies (rash, swelling, redness, itching);
blood thinning and possible bleeding (with prolonged treatment);
eczema,
digestive disorders, diarrhea, nausea, abdominal pain;
dizziness, headaches, tinnitus.

While using the drug, it is better not to perform activities that require increased attention and rapid psychomotor reactions. This is associated with possible dizziness.

Results of interactions with other drugs

Tanakan tablets are well compatible with almost any other drugs. The exceptions are Aspirin or Warfarin, the combination with which increases the risk of bleeding.

When using a solution, you need to take into account the reaction to alcohol when combined with:

Disulfiram,
Latamoxefom,
Chloramphenicol,
Trichopolum,
Glipizide,
Cefomandole,
Ketoconazole,
Metronidazole, etc.

Directions for use and dosage

Before using TANAKAN you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

Clinical and pharmacological group

01.072 (Phytopreparation that improves cerebral and peripheral blood circulation)

Release form, composition and packaging

The tablets are brick-red, round, biconvex; when broken, light brown in color, with a specific odor.

Excipients: lactose monohydrate, microcrystalline cellulose, corn starch, colloidal silicon dioxide, talc, magnesium stearate.

Shell composition: hypromellose, macrogol 400, macrogol 6000, titanium dioxide, red iron dioxide.

15 pcs. - blisters (2) - cardboard packs. 15 pcs. - blisters (6) - cardboard packs.

The solution for oral administration is brownish-orange in color, with a characteristic odor.

Excipients: sodium saccharinate - 500 mg, orange flavor - 750 µl, lemon flavor - 750 µl, ethanol 96% - 59 ml, purified water - up to 100 ml.

30 ml - dark glass bottles (1) complete with a dispenser pipette (1 ml capacity) - cardboard packs.

pharmachologic effect

A standardized and titrated preparation of plant origin, the effect of which is due to the influence on metabolic processes in cells, the rheological properties of blood, as well as on the vasomotor reactions of blood vessels.

The drug improves the supply of oxygen and glucose to the brain. Normalizes the tone of arteries and veins, improves microcirculation. Helps improve blood flow, prevents red blood cell aggregation. Has an inhibitory effect on platelet activating factor.

Improves metabolic processes and has an antihypoxic effect on tissues. Prevents the formation of free radicals and lipid peroxidation of cell membranes. Affects the release, reuptake and catabolism of neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin) and their ability to bind to membrane receptors.

Pharmacokinetics

Ginkgolides A and B and bilobalides have an oral bioavailability of 80% to 90%. Cmax is reached within 1-2 hours; T1/2 ranges from 4 hours (ginkgolide A and bilobalide) to 10 hours (ginkgolide B). The main route of elimination is the kidneys.

TANAKANA: DOSAGE

Prescribe 40 mg (1 tablet or 1 ml) 3 times a day with meals.

Taken orally. The tablet should be taken with half a glass of water, the oral solution should be dissolved in half a glass of water. When taking the drug in the form of an oral solution, use the supplied dispenser pipette (1 dose = 1 ml of solution).

The minimum course of treatment is 3-6 months.

Overdose

Currently, there are no known cases of overdose of Tanakan®.

Drug interactions

In clinical studies with EGb 761, both inhibition and induction of cytochrome P450 isoenzymes were detected. When EGb 761 was co-administered with midazolam, midazolam levels were altered, presumably due to an effect on CYP3A4. Therefore, caution should be exercised when co-administering EGb 761 and drugs metabolized by the CYP3A4 isoenzyme.

With simultaneous use of Tanakan in the form of an oral solution with antibiotics of the cephalosporin group (cefamandole, cefoperazone, latamoxef), gentamicin, chloramphenicol, disulfiram, thiazide diuretics, anticonvulsants, oral hypoglycemic drugs (chlorpropamide, glibenclamide, glipizide, tolbutamide, metformin ( possible development lactic acidosis)), antifungal drugs (griseofulvin), 5-nitroimidazole derivatives (metronidazole, ornidazole, tinidazole), cytostatics (procarbazine), tricyclic antidepressants, tranquilizers, reactions such as hyperthermia, hyperemia of the skin, vomiting, increased heart rate may occur, since 1 dose Tanakana in the form of an oral solution contains 450 mg of ethyl alcohol.

The drug should not be used by patients systematically using warfarin.

Pregnancy and lactation

The use of Tanakan® is contraindicated during pregnancy and lactation due to the lack of clinical data.

TANAKANA: SIDE EFFECTS

From the central nervous system: uncommon (≥ 0.1% -

From the digestive system: uncommon (≥ 0.1% -

Dermatological reactions: uncommon (≥ 0.1% -

Allergic reactions: with unknown frequency - redness, skin rash, swelling, itching, urticaria.

From the blood coagulation system: with unknown frequency - decreased blood clotting and the possibility of bleeding (with long-term use).

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. The shelf life of the tablets is 4 years. The shelf life of the oral solution is 3 years.

Indications

cognitive and neurosensory deficits of various origins (with the exception of Alzheimer's disease and dementia of various etiologies);
intermittent claudication in chronic obliterating arteriopathy of the lower extremities;
visual impairment of vascular origin,
reducing its severity;
hearing impairment,
noise in ears,
dizziness and coordination disorders, predominantly of vascular origin;
Raynaud's disease and syndrome.

Contraindications

pregnancy;
lactation period (breastfeeding);
hypersensitivity to any of the components of the drug.

For oral solution:

erosive gastritis in the acute stage;
peptic ulcer of the stomach and duodenum in the acute stage;
acute cerebrovascular accidents;
acute myocardial infarction;
decreased blood clotting;
age up to 18 years.

The solution should be prescribed with caution to patients with alcoholism, liver diseases, traumatic brain injuries and brain diseases, since the drug in the form of a solution contains 450 mg of ethyl alcohol per 1 dose (1 dose).

special instructions

Improvement in the condition appears 1 month after the start of treatment.

Since Tanakan® in tablet form contains lactose, it should not be prescribed to patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or lactase deficiency.

One single dose of the oral solution contains 450 mg of ethyl alcohol (57% v/v), the maximum daily dose is 1.35 g of ethyl alcohol.

Impact on the ability to drive vehicles and operate machinery

While taking the drug, it is not recommended to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms), because the drug may cause dizziness and the solution contains ethyl alcohol.

Conditions for dispensing from pharmacies

The tablets are available with a prescription.

The oral solution is approved for use as an over-the-counter product.

Older people often have memory impairment and cognitive impairment. The natural remedy Tanakan perfectly helps to cope with such problems.

Tanakan - description and action

Tanakan is a popular angioprotector, which is often found among the prescriptions of neurologists and is of plant origin. The drug is produced in two forms - tablets and oral solution. The price for 30 tablets is 600 rubles, for 30 ml of solution - 590 rubles. Medicines can be taken depending on the more comfortable method - they are completely interchangeable. The products are manufactured in France by Bofur Ipsen Industry.

The active substance of the medicine is ginkgo biloba (extract), another name for the plant is ginkgo biloba.

The medicinal properties of ginkgo biloba are beyond doubt. This plant includes flavone glycosides, terpenes, specific substances - bilobalides, ginkgolides, as well as a number of organic acids, anthocyanins and proanthocyanidins. All these substances provide ginkgo biloba, as the main component of Tanakan, with powerful angioprotective properties.

The drug can influence metabolic processes in brain cells and also has other beneficial effects:

As a result of taking Tanakan, overall brain activity and vascular function significantly improves.

Main indications

The medicine is intended for use in adults; it is not recommended for children. Most often, the use of Tanakan is justified in old age, since it is in older people that memory impairment and other types of brain activity are observed. The drug is prescribed for the following conditions:

The drug can be used as a symptomatic remedy for ringing in the ears and is used in the complex treatment of vertigo. For atherosclerosis and cervical osteochondrosis, indications for treatment with Tanakan include visual disturbances, impaired visual acuity, and blurriness. Indications include disease, Raynaud's syndrome, mixed arteriopathy affecting the lower extremities. In the latter case, tablets or solution are drunk to reduce signs of intermittent claudication.

Tanakan contraindications

The main contraindication is the age limit of up to 18 years; you should also not take the medicine if you are intolerant to ginkgo biloba, or if you develop allergic reactions to taking it. Acute gastrointestinal diseases prohibit therapy, these include:

In the presence of chronic forms of these pathologies, treatment is possible according to strict indications and is carried out with caution. For such patients, it is better to prescribe the medicine in a short course.

Treatment for acute forms of cerebral blood flow disturbance is prohibited.

Tanakan should not be taken in the acute phase of myocardial infarction or with unstable angina. Due to the presence of a number of additional components, lactose intolerance, lactase deficiency, and galactosemia are also contraindications. Since the product thins the blood, it is forbidden to drink it if you have blood diseases that cause decreased clotting. During pregnancy and lactation, treatment is also contraindicated - sufficient research has not been conducted. They are treated with great care for alcoholism, after traumatic brain injuries, and for impaired liver and kidney function.

How to take the medicine?

The admission procedure is as follows. Tablets or solution should be taken three times a day. To avoid unpleasant reactions from the gastrointestinal tract, this should be done during meals. It is acceptable to take Tanakan immediately after meals. The tablets should be taken with half a glass of water. The solution is diluted in the same amount of water at room temperature.

The minimum course of treatment is 3-6 months, it can be extended up to a year.

The solution must be used by using a dispenser pipette, after which the drops are poured into water. The dosage rate for one time is 1 ml of solution or 1 whole tablet.

You should strictly follow the course recommended by your doctor; it should be extended or stopped after consultation. No cases of overdose have been described, but the number of tablets cannot be increased. A pronounced therapeutic effect occurs only after a month of treatment; you should not expect it in the first days and weeks of therapy, nor should you stop taking it.

Analogues and other information for the patient

Side effects may include allergic reactions - rash, swelling, itching of the skin. A decrease in coagulability is possible due to a decrease in platelet aggregation. If the course is too long, there is a risk of bleeding. From the nervous system, headaches are possible, from the gastrointestinal tract - nausea, heartburn, belching, stomach pain. If there are side effects, you will have to refuse treatment and select a drug with another active substance from the group of angioprotectors.

ПN011709/02

Trade name of the drug:

Tanakan®

International nonproprietary name:

Ginkgo biloba leaf extract

Dosage form:

oral solution

Compound:

Oral solution 40 mg/ml (composition per 100 ml):
active substance: Ginkgo biloba leaf extract (EGb 761 ®): 24% flavonol glycosides and 6% ginkgolide bilobalides - 4000.00 mg
Excipients: sodium saccharinate - 500.00 mg, orange flavor - 0.75 ml, lemon flavor -0.75 mg, ethanol (96%) - 59.00 ml, purified water - up to 100.00 ml.

Description:

The solution is brownish-orange in color with a characteristic odor.

Pharmacotherapeutic group:

Angioprotective agent of plant origin

ATX code:

N06DX02

Pharmacological properties

Pharmacodynamics
A standardized and titrated preparation of plant origin, the effect of which is due to the influence on metabolic processes in cells, the rheological properties of blood, as well as the vasomotor reactions of blood vessels.
The drug improves the supply of oxygen and glucose to the brain. Normalizes the tone of arteries and veins, improves microcirculation. Helps improve blood flow, prevents red blood cell aggregation. Has an inhibitory effect on platelet activating factor. Improves metabolic processes and has an antihypoxic effect on tissues. Prevents the formation of free radicals and lipid peroxidation of cell membranes. Affects the release, reuptake and catabolism of neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin) and their ability to bind to membrane receptors.
Ginkgolides A and B and bilobalides have an oral bioavailability of 80% to 90%. The maximum concentration is reached after 1-2 hours; The half-life ranges from 4 hours (ginkgolide A and bilobalide) to 10 hours (ginkgolide B). The main route of elimination is the kidneys.

Indications for use

cognitive and neurosensory deficits of various origins (with the exception of Alzheimer's disease and dementia of various etiologies);
intermittent claudication in chronic obliterating arteriopathy of the lower extremities;
visual impairment of vascular origin, decreased visual acuity;
hearing impairment, tinnitus, dizziness and movement coordination disorders mainly of vascular origin;
Raynaud's disease and syndrome.

Contraindications

Age up to 18 years.
Hypersensitivity to any of the components of the drug, erosive gastritis in the acute stage, peptic ulcer of the stomach and duodenum in the acute stage, acute cerebrovascular accidents, acute myocardial infarction, pregnancy and lactation, decreased blood clotting.
Carefully
Since the drug in the form of a solution contains 0.45 g of ethyl alcohol per dose (one dose), it should be prescribed with caution to patients with alcoholism, liver disease, traumatic brain injury and brain diseases.

Use during pregnancy and breastfeeding

Due to the lack of clinical experience, data on taking the drug during pregnancy and breastfeeding have not been accumulated and the use of the drug in this group of patients is contraindicated.

Directions for use and doses

Orally for adults, 1 ml of solution 3 times a day with meals.
First dissolve in ½ glass of water, use the supplied dispenser pipette, 1 dose = 1 ml of solution.
The minimum course of treatment is 3 - 6 months.

Side effect

Not often (> 0.1% -<1%): головная боль, головокружение, тошнота, абдоминальная боль, сыпь, зуд, экзема.
Experience with the use of the drug in routine practice (with a frequency that cannot be estimated on the basis of available data): allergic reactions (redness, skin rash, swelling, itching), dyspepsia, diarrhea, urticaria, decreased blood clotting and the possibility of bleeding (with prolonged application).
If any adverse events occur, stop taking the drug and consult your doctor.

Overdose

There are no known cases of drug overdose.

Interaction with other drugs

In clinical studies with EGb 761, both inhibition and potentiation of cytochrome P450 enzymes were detected. When EGb 761 was co-administered with midazolam, midazolam levels were altered, presumably due to an effect on CYP3A4. Therefore, caution should be exercised when coadministering EGb 761 and drugs metabolized by CYP3A4.

Since the drug in the form of a solution contains 0.45 g of ethyl alcohol per dose (one dose), it is necessary to avoid simultaneous use with drugs of the following groups due to the possible occurrence of such reactions as hyperthermia, flushing of the skin, vomiting, increased heart rate:

antibiotics - cephalosporins (cefamandole, cefoperazone, latamoxef);
gentamicin;
chloramphenicol;
disulfiram;
thiazide diuretics;
anticonvulsants;
antidiabetic hypoglycemic agents (chlorpropamide, glibenclamide, glipizide, tolbutamide, metformin (possible development of lactic acidosis));
fungicides (griseofulvin);
5-nitroimidazole (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole;
cytostatics (procarbazine);
tricyclic antidepressants;
tranquilizers.

The drug should not be used by patients systematically using acetylsalicylic acid or warfarin.

special instructions

Before using the drug, consult a doctor. Improvement in the condition appears 1 month after the start of treatment.
One single dose contains 0.45 g of ethyl alcohol (57% V/V), the maximum daily dose contains 1.35 g of ethyl alcohol.

Impact on the ability to drive vehicles and machinery

While taking the drug, it is not recommended to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms) (since the drug can cause dizziness and contains ethyl alcohol).

Release form

Oral solution 40 mg/ml:
30 ml in a dark glass bottle with a screw-on plastic cap. The bottle and dispenser pipette in a plastic container with a capacity of 1 ml, together with instructions for use, are placed in a cardboard pack.

Storage conditions

At a temperature not exceeding 25°C, out of the reach of children.

Best before date

3 years.
Do not use after the expiration date stated on the package.

Vacation conditions

Available without a prescription.

Manufacturer

Bofur Ipsen Industry
France, 28100 Dreux

If necessary, consumer complaints should be sent to the representative office in the Russian Federation:
109147, Moscow, Taganskaya st., 19