Panadol from 3 years. Trade patent name

Latin name: Panadol
ATX code: N02B E01
Active substance: Paracetamolum
Manufacturer: GlaxoSmithKline (England,
Greece, Ireland, France)
Conditions for dispensing from a pharmacy: Over the counter

Panadol is a line of antipyretic and painkillers intended for the symptomatic treatment of colds, flu and other infectious and inflammatory diseases in adults and children.

Indications for use

The medicine Panadol is designed for:

Relieving hyperthermia and fever in various infectious and inflammatory diseases
Elimination of pain of weak/strong intensity and different localization (for migraines, headaches, back pain, joint pain, muscle pain, dental pain).

Panadol Children's is designed to reduce hyperthermia and pain during infectious and inflammatory diseases, as well as otitis media, teething, head and throat pain.

Composition of the drug

Panadol is produced with different levels of paracetamol.

For adults:

Effervescent tablets: one pill contains 500 mg of active ingredient. Other components – E420, E954, baking soda, povidone, SLS, dimethicone, citric acid, sodium carbonate.
Film-coated tablets: one piece contains 500 mg of medicinal substance. Other ingredients - corn and pregelatinized starches, E202, povidone, talc, octadecanoic acid, E1518, hypromellose.

Panadol Baby for children:

Oral suspension: 5 ml of syrup contains 120 mg of active ingredient. Other substances – malic acid, E415, E965, E420, E215, E217, E219, citric acid, purified water.
Rectal suppositories: one suppository contains 125 or 250 mg of paracetamol. The substance that provides the structure of the drug is solid fat (about 0.83 g).

Medicinal properties

Panadol series drugs have antipyretic and analgesic effects. The paracetamol they contain belongs to the group of non-steroidal anti-inflammatory drugs. The substance is capable of suppressing the formation of cyclooxygenase enzymes (primarily prostaglandins) in the central nervous system, which are responsible for thermoregulation of the body and pain.

The substance also has an anti-inflammatory effect, but to a lesser extent.

After oral administration, paracetamol is absorbed in large quantities in the gastrointestinal tract. Peak plasma levels are reached after 20-60 minutes. Similar characteristics are observed during therapy with rectal suppositories, but in this case the therapeutic effect occurs a little faster.

Paracetamol is transformed in the liver, its metabolites are excreted by the kidneys. The half-life of elimination from the body takes from 1 to 4 hours. If there are disturbances in the functioning of the organ, the process takes a longer time.

Release forms

Panadol for adults:

Dissolution tablets are white pills with beveled edges. There is a dividing strip on one surface. The product is packaged in strips of 2 pieces. The box contains 6 packages, annotation.
Coated tablets: white in capsule form. On one surface there is a mark in the middle, on the other there is an extruded image of a triangle. The pills are packaged in blisters of 6 pieces. The pack contains 1 or 2 records, a manual insert.

Products for children:

Panadol Children - syrup for oral use. The liquid is deep pink in color and smells like strawberries. The consistency is viscous, jelly-like with inclusions in the form of crystals. The taste is moderately sweet. The suspension is packaged in 120 mg doses, placed in a dark bottle. A pack of thick paper contains one product, a measuring syringe with divisions, and an annotation.
Suppositories - suppositories for rectal administration, are white or whitish. They have a cone shape. The structure is homogeneous, without any inclusions. Candles are packaged in 5 pieces per cell packaging. The pack contains 1 or 2 strips, a manual insert.

Mode of application

Before starting treatment, it is better to consult a doctor. If this is not possible, then use Panadol tablets according to the attached instructions for use.

Tablets (500 mg) coated

Cost – 59 rubles.

Single dosage for adults – 1-2 tablets. The time interval between doses is at least 4 hours. You can take a maximum of 8 tablets per day.

From 6 to 9 years: one-time dose – maximum 0.5 tablet. The permissible daily amount is 2 tablets.
From 9 to 12 years: single dose – 1 tablet, maximum number of doses – 4 times a day

Soluble tablets (500 mg)

Price: (12 pcs.) – 58 rub.

The medicine is diluted in water immediately before administration, using at least 100 ml of water.

Adults can take 2 tablets at a time, each dose 4 hours after the previous one. The maximum allowable amount of drugs per day is 8 pieces.
Children aged 6 years to 12 can be given 0.5-1 tablet. at a time, per day - maximum 2 pieces.

How to take Panadol Baby syrup

Cost – from 90 rubles.

The dosage is calculated individually, depending on the weight and age of the child. If there is no prescription, children's Panadol syrup is given according to the instructions for use. Before taking, shake the liquid thoroughly and then measure out a single dose with the included syringe.

For babies from 3 months of age, Panadol is prescribed 15 mg per 1 kg of weight, a maximum of 60 mg per 1 kg per day is allowed. The medicine is taken 3 or maximum 4 times a day.

Panadol Children's suppositories

Price: (10 pcs.) 66 rub.

Suppositories 125 mg: single dosage for children aged 3 months to 3 years – 1 suppository. The drug is administered rectally at intervals of 4-6 hours. A maximum of 3 candles per day is allowed.

Suppositories 250 mg: a single dose is determined by the doctor, depending on the indications there may be 1 or 2 suppositories. The maximum permissible number of procedures is 4 times a day with an interval of at least 4 hours.

From 1 year to 5 years: 125-250 mg of paracetamol per dose is allowed
From 3 years to 6: 250-500 mg

During pregnancy and breastfeeding

Paracetamol has the ability to pass through the placental barrier and is excreted into breast milk. Although its negative effect on the fetus has not yet been discovered, for safety reasons the use of Panadol during pregnancy and breastfeeding is not recommended.

Treatment is possible only with the consent of the doctor and under his supervision. It is advisable for nursing women to interrupt lactation during drug therapy.

Contraindications

Prohibitions on the use of Panadol are:

Increased reaction of the body to paracetamol and its constituent components
Newborn age (up to 1 month)
G-6-PD deficiency
Phenylketonuria
Blood diseases
Genetic fructose intolerance, lactase deficiency, glucose-galactose malabsorption (for suspension).

Age restrictions for children:

Suspension should not be given before 3 months
Panadol suppositories are prohibited for up to 6 months
Tablets (soluble and coated) should not be given to children under 6 years of age.

Cautious use is allowed when:

Impaired functioning of the kidneys and liver (including due to alcoholism)
Benign hyperbilirubinemia
Hepatitis of viral origin
Pregnancy and breastfeeding
Old age.

Precautionary measures

Panadol is designed to relieve the symptoms of the disease, but not its cause. Therefore, the drug should be used with other drugs aimed at eliminating the underlying disease.

People following a salt-free diet should be aware that the coated tablets contain sodium.

When taking tests, you must inform about the Panadol you are taking, since paracetamol can distort test results.

The use of rectal suppositories for 2-3 month old babies, as well as those born prematurely, is possible only as prescribed by a pediatrician.

Cross-drug interactions

When treating with Panadol, it is necessary to take into account the properties of drugs taken in parallel, since paracetamol may react with them.

It reduces the effectiveness of Probenecid and other drugs that reduce uric acid levels in the body.
When combined with anticoagulants, it enhances their effect (Warfarin, Thrombostop, etc.).
The therapeutic effect of Panadol is reduced by combination with barbiturates.
The hepatoxicity of Panadol increases when taken together with Phenytoin, Rifampicin, tricyclic antidepressants, Diflusanil. In this case, intoxication is possible even with a small amount of paracetamol taken.
Simultaneous treatment with liver enzyme inhibitors reduces the toxic effects of paracetamol on the liver.
The drug cannot be combined with alcohol-containing drugs or drinks.
When Panadol is combined with salicylates, the risk of developing kidney or bladder cancer increases, and when combined with other NSAIDs, it can lead to serious complications of the kidneys, including the development of kidney failure.

Side effects

Although all forms of Panadol are usually tolerated normally, negative reactions of the body to the substances contained in the drug are also possible. Side symptoms affect various organs and internal systems, manifesting themselves in the form of:

Gastrointestinal tract: Nausea, vomiting, epigastric pain, laxative effect
Liver: enzyme activation, organ failure
Hematopoietic system: changes in blood composition, anemia
Allergies: skin reactions, angioedema, anaphylaxis
Other symptoms: bronchospasm, decreased blood glucose concentration (including hypoglycemic coma).

Overdose

During treatment with Panadol, you should adhere to the prescribed doses, not exceeding them, so as not to provoke poisoning. In the case of intentional or accidental intake of large doses of the drug, intoxication develops.

Within 24 hours after administration, side effects appear as:

Nausea, vomiting
Epigastric pain
Increased sweating
Skin paleness.

Within 48 hours, symptoms of liver damage occur:

Soreness
Activation of liver enzymes
Liver failure
Encephalopathy
Coma.

Long-term use of overdoses provokes serious disorders of the kidneys and liver. The result is renal colic, necrotizing papillitis, bacteriuria.

If signs of poisoning appear, you must stop taking the medication and immediately contact your doctor. The victim should clear the stomach of any remaining medication and give an adsorbent to drink. If necessary, the doctor can administer acetylcysteine, which is an antidote to paracetamol.

It is worth paying close attention to the condition of children during treatment with Panadol Children's drugs, since intoxication develops especially quickly in children's bodies. Even if a child has taken a lot of medicine, but feels fine, he still needs to be shown to a pediatrician. There is a high chance of delayed liver damage.

Conditions and shelf life

The preparations should be kept away from sunlight and heating devices; storage temperature should be up to 30 °C. Cannot be frozen.

The shelf life of coated tablets is 5 years, effervescent tablets are 4 years, suppositories are 5 years, and children’s syrup is 3 years.

Analogs

You can reduce the temperature and eliminate pain with the help of other drugs containing paracetamol.

Efferalgan

UPSA SAS (France)

Price: capsules (16 pcs.) – 143 rubles, thorn. table (16 pcs.) – 146 rub., supp. (10 pcs.) – 99-112 rub., powder. (12 pcs.) – 118 rub.

A popular symptomatic remedy based on paracetamol. It is produced in capsules, tablets for dissolution, oral solution, rectal suppositories with varying contents of the active substance.

Quickly relieves fever and eliminates pain in various diseases.

Pros:

High quality
You can choose the most suitable form.

Flaws:

Bitter taste
Doesn't always help with toothache.

P No. 011292/01

Trade patent name

Children's Panadol

International nonproprietary name

Paracetamol

Dosage form

Oral suspension

Composition (per 5 ml suspension)

Active substance: paracetamol 120 mg.
Excipients: malic acid 2.5 mg, xanthan gum 35.0 mg, maltitol 3500.0 mg, sorbitol 70% crystalline 666.5 mg, sorbitol 105.0 mg, citric acid 1.0 mg, mixture of parahydroxybenzoic acid esters (methyl-, sodium ethyl-, propyl parahydroxybenzoates) 7.5 mg, strawberry flavor L10055 5.0 mg, azorubine dye 0.05 mg water up to 5.0 ml.

Description

Pink viscous liquid with a strawberry odor, containing crystals.

Pharmacotherapeutic group

Analgesic non-narcotic drug.

ATX code

Pharmacological properties

Pharmacodynamics.
The drug has analgesic and antipyretic properties. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent. It does not affect the condition of the gastrointestinal mucosa and water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.
Pharmacokinetics.
Absorption is high - Panadol is quickly and almost completely absorbed from the gastrointestinal tract. Plasma protein binding is about 15%. Peak plasma concentrations are reached after 30-60 minutes.
The distribution of paracetamol in body fluids is relatively even.
Metabolized primarily in the liver with the formation of several metabolites. In newborns in the first two days of life and in children 3-10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children 12 years of age and older, it is conjugated glucuronide. Part of the drug (approximately 17%) undergoes hydroxylation to form active metabolites that are conjugated with glutathione. With a lack of glutathione, these metabolites of paracetamol can block the enzyme systems of hepatocytes and cause their necrosis.
The half-life when taking a therapeutic dose ranges from 2-3 hours.
When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is released after conjugation in the liver. No more than 3% of the received dose of paracetamol is excreted unchanged.

Indications for use

Used in children from 3 months to 12 years as:

antipyretic - to reduce elevated body temperature against the background of colds, flu and childhood infectious diseases (chicken pox, mumps, measles, rubella, scarlet fever, etc.)
pain reliever - for toothache, including teething, headache, earache with otitis media and sore throat.

For children 2-3 months of age, a single dose is possible to reduce fever after vaccination. If the temperature does not decrease, consult a doctor.

Contraindications

hypersensitivity to paracetamol or any other ingredient of the drug;
severe liver or kidney dysfunction;
neonatal period;

Carefully

Use with caution in cases of liver dysfunction (including Gilbert's syndrome), kidney dysfunction, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, severe forms of blood diseases (severe anemia, leukopenia, thrombocytopenia).
If you have any of the listed diseases, you should consult your doctor before taking the drug.

Directions for use and doses

For oral administration.
Before use, the contents of the bottle must be shaken well for at least 10 seconds.
The measuring syringe placed inside the package allows you to dose the drug correctly and rationally.
The dose of the drug depends on the age and body weight of the child.
Children (from 3 months to 12 years)
The maximum single dose is 15 mg/kg body weight. The maximum daily dose is 60 mg/kg body weight. The frequency of administration is no more than 3-4 times a day. If necessary, you can give your child the recommended dose every 4-6 hours, but not more than 4 doses in 24 hours.
In all other cases, before taking the drug "Children's Panadol" you need to consult a doctor.

		Dose
Body weight (kg)	Age	One-time		Maximum daily
Body weight (kg)	Age	ml	mg	ml	mg
4,5-6	2-3 months	Only on doctor's orders
6-8	3-6 months	4.0	96	16	384
8-10	6-12 months	5.0	120	20	480
10-13	1-2 years	7.0	168	28	672
13-15	2-3 years	9.0	216	36	864
15-21	3-6 years	10.0	240	40	960
21-29	6-9 years	14.0	336	56	1344
29-42	9-12 years	20.0	480	80	1920

Duration of use without consulting a doctor is 3 days.

Do not exceed the recommended dose!
If you accidentally exceed the recommended dose, you should immediately consult a doctor, even if the child feels well, as there is a risk of developing liver damage (see “Overdose”).
If the child's condition does not improve while taking the drug, consult a doctor.

Side effects

Side effects are classified by organ system and frequency. The frequency of side effects is defined as follows: very common (greater than or equal to 1/10), common (greater than or equal to 1/100 and less than 1/10), uncommon (greater than or equal to 1/1000 and less than 1/100), rare ( greater than or equal to 1/10,000 and less than 1/1000) and very rare (greater than or equal to 1/100,000 and less than 1/10,000).
Allergic reactions:
Very rarely - in the form of skin rashes, itching, urticaria, angioedema, Stevens-Johnson syndrome, anaphylaxis;
From the hematopoietic system:
Very rarely - thrombocytopenia, anemia, leukopenia;
From the respiratory system:
Very rarely - bronchospasm (in patients with hypersensitivity to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs);
From the hepatobiliary system:
Very rarely - liver dysfunction.
Sometimes nausea, vomiting, and pain in the stomach are possible.
If any of these side effects occur, stop taking the drug and consult your doctor immediately.

Overdose

Symptoms: during the first 24 hours after an overdose - nausea, vomiting, stomach pain, sweating, pale skin, anorexia. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of “liver” enzymes). Possible development of carbohydrate metabolism disorders and metabolic acidosis. In adult patients, liver damage develops after taking more than 10 g of paracetamol; in children, when taking more than 125 mg/kg of the child’s body weight. If there are factors that influence the toxicity of paracetamol to the liver (see section “Interaction with other drugs”, “Special instructions”), liver damage is possible after taking 5 or more grams of paracetamol.
In severe cases of overdose, encephalopathy (impaired brain function), bleeding, hypoglycemia, cerebral edema, and even death may develop as a result of liver failure. It is possible to develop acute renal failure with acute tubular necrosis, the characteristic signs of which are pain in the lumbar region, hematuria (admixture of blood or red blood cells in the urine), proteinuria (increased protein in the urine), while severe liver damage may be absent. There have been cases of heart rhythm disturbances and pancreatitis.
With long-term use in excess of the recommended dose, hepatotoxic and nephrotoxic effects (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis) may be observed.
Treatment: If an overdose is suspected, even in the absence of pronounced first symptoms, it is necessary to stop using the drug and immediately seek medical help. Within 1 hour after an overdose, it is recommended to lavage the stomach and take enterosorbents (activated carbon, polyphepan). The level of paracetamol in the blood plasma should be determined, but not earlier than 4 hours after the overdose (earlier results are unreliable). Administration of acetylcysteine within 24 hours of an overdose. The maximum protective effect is provided during the first 8 hours after an overdose; over time, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine is administered intravenously. In the absence of vomiting, methionine can be used before the patient is admitted to the hospital. The need for additional therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration. Treatment of patients with severe liver dysfunction 24 hours after taking paracetamol should be carried out in conjunction with specialists from a poison control center or specialized liver disease department.

Interaction with other drugs

If the child is already taking other medications, you should consult a doctor before starting to take Children's Panadol. Barbiturates, carbamazepine, phenytoin, diphenin, primidone and other anticonvulsants, ethanol, rifampicin, zidovudine, flumecinol, phenylbutazone, butadione, preparations of St. John's wort and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of developing severe liver damage with small overdoses of paracetamol (5 g or more).
Inhibitors of microsomal liver enzymes reduce the risk of hepatotoxicity.
Under the influence of paracetamol, the elimination time of chloramphenicol (chloramphenicol) increases by 5 times, resulting in an increased risk of chloramphenicol (chloramphenicol) poisoning.
When taken regularly over a long period of time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Occasional administration of a single dose of the drug does not have a significant effect on the effect of indirect anticoagulants. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.

special instructions

Children under 3 months of age and children born prematurely should only be given Children's Panadol as prescribed by a doctor.
When performing tests to determine uric acid and blood sugar levels, tell your doctor about the use of the drug "Children's Panadol".
When taking the drug for more than 7 days, monitoring of peripheral blood and liver function is recommended.
Glutathione deficiency due to eating disorders, cystic fibrosis, HIV infection, fasting, and exhaustion makes it possible to develop severe liver damage with small overdoses of paracetamol (5 g or more).
The drug should not be used simultaneously with other paracetamol-containing drugs.
"Children's Panadol" contains maltitol and sorbitol. Patients with rare hereditary fructose intolerance should not take this drug.
The drug contains a mixture of parahydroxybenzoic acid esters (sodium methyl, ethyl, and propyl parahydroxybenzoates), which may cause delayed allergic reactions.
"Children's Panadol" does not contain sugar, alcohol and acetylsalicylic acid.

Release form

Inflammation is a kind of protective reaction of the body to various pathogens (bacteria, viruses, chemical compounds). At the same time, the body releases special substances into the blood; waste products poison the child’s body. For pain relief and elimination of unpleasant symptoms, a non-steroidal drug is used - Panadol Baby syrup.

The drug effectively copes with the baby’s fever and relieves pain that accompanies almost every cold. Children's Panadol is very popular among parents; in most cases, the medication is reviewed positively.

Pharmacological properties

Panadol for children belongs to the group of non-steroidal anti-inflammatory and antiseptic drugs. The active component is paracetamol, a substance that can block inflammatory mediators that provoke the inflammatory process, increased body temperature, and other unpleasant symptoms of a cold.

A distinctive feature of the drug is the slight anti-inflammatory activity of the component, after all, when a substance enters the blood, it begins to break down under the action of cell membrane enzymes. The drug has a loyal effect on the children's body, in rare cases it causes side effects. According to the instructions, the maximum concentration of Panadol Baby is reached after half an hour, so the medicine acts quickly and significantly alleviates the baby’s condition.

The destruction of the drug elements occurs in the liver, then the active component of the syrup is excreted by the kidneys. If the dosage is observed, the drug does not disturb the electrolyte balance, water retention does not occur, and the functioning of the gastrointestinal tract remains normal.

Composition and release form

Panadol Baby is produced in the form of syrup for oral administration. The bottle contains 100 ml of medicine, a convenient dispenser makes the process of taking the medicine easier. The liquid has a pinkish color, a characteristic viscous consistency and a pleasant strawberry aroma. The manufacturer produces the product in the form of pills, powder, solution for infusion, and rectal suppositories. For children, a suspension is most often used. Pleasant taste and ease of use have earned the love of many children and their parents.

The main component of Panadol for children is paracetamol. The substance was first synthesized in the USA back in 1887. It was tested and studied for quite a long period of time, and some scientists doubted its effectiveness. Mass production of paracetamol began only in 1953, and the substance is extremely popular today.

Paracetamol was originally used as a pain reliever for varying degrees of pain. In addition, the substance was actively used to solve problems with the gastrointestinal tract in children.

Note! During the research, it was found that Panadol acts effectively, copes well with headaches, toothaches, fever, and alleviates colds. Exceeding the dosage is not allowed, due to the high risk of side effects if the recommendations described in the instructions are not followed.

Indications for use

Children's Panadol is used in the following cases:

to lower the baby’s body temperature, reduce the unpleasant symptoms of colds (flu, and others);
relief, including with;
elimination of pain from otitis media, sinusitis, tonsillitis, ;
sometimes used to alleviate the condition of various neuralgic problems (only with the permission of the doctor);
in some cases, they are used once for children 2–3 months after vaccination. The instructions indicate that the drug copes with unpleasant sensations and reduces the risk of side effects after vaccination.

Panadol is approved for use by children from three months to twelve years. Before using the medicine, consult your pediatrician, strictly follow his recommendations.

Contraindications

Children's Panadol is prohibited from taking in the following cases:

the presence of hypersensitivity to paracetamol or other components of the drug;
blood diseases;
children up to three months of age (can only be taken with the permission of the pediatrician);
serious liver dysfunction;
kidney pathologies;
It is not recommended to combine it with other drugs containing paracetamol.

Before use, be sure to carefully read the instructions and follow the helpful instructions.

Possible side effects

Exceeding the dosage or individual intolerance to the components of the medication leads to a number of unpleasant consequences.

Improper functioning of the gastrointestinal tract:

loss of appetite;
attacks of nausea;
loss of appetite, lethargic state of the baby;
severe pain in the intestinal or stomach area;
Excessive, constant excess of the dosage leads to necrosis of liver cells, resulting in liver failure.

Nervous system problems:

in some cases, there is increased activity of the baby, insomnia, and excessive anxiety;
A single dose of a large amount of Panadol leads to dizziness, severe pain in the temples, and sometimes loss of consciousness.

Immune system response (allergic reactions):

swelling of the respiratory tract, Quincke's edema;
rash on the body, redness in the area of formations;
the most serious complication is Stephen-Jones syndrome (which is drug-induced tissue necrosis). Sometimes Lyell's syndrome (damage to epidermal tissues) appears. Pathological conditions require immediate medical intervention and urgent resuscitation.

Lesions of the hematopoietic organs:

Children experience pallor of the skin of the face, cyanosis of the nasolabial triangle, and sometimes feel pain in the heart area;
thrombocytopenia is noted, which is accompanied by excessive bleeding and poor blood clotting;
Long-term, uncontrolled use of the medication leads to disturbances in the functioning of the bone marrow.

From the endocrine system:

glycemic coma;
lowering blood sugar levels.

Sometimes kidney failure and problems with urination develop.

Instructions for use and dosage

Panadol syrup for children is taken orally, Before use, be sure to stir the suspension in the bottle. Using a measuring syringe, draw up the required amount of product and pour it into the baby’s mouth. After use, rinse the device.

Approximate regimen of use and dosage of Panadol:

2–3 months– individual dosage is prescribed exclusively by the attending physician;
3–6 months– give the baby 4 ml, the maximum permissible daily dose is 16 ml;
from 6 months to 1 year– 5 ml up to four times a day;
from one to two years– 7 ml, per day up to 28 ml;
from one to two years– 9 ml, allowed to use up to 36 ml per day;
from three years to six years– 10 ml, the maximum allowed to give the baby is 40 ml;
from six to nine years– 14 ml, you can give the baby 56 ml per day;
from nine to twelve years– 20 ml, 80 ml can be taken daily.

Anyway the specific dosage is prescribed by the attending physician, It is not advisable to give the drug to your child yourself.

Interaction with other drugs

Panadol for children It is not recommended to combine it with other anti-inflammatory, antipyretic medicinal products. Even when combined with multivitamins, notify your doctor. The child's body is very sensitive and reacts sharply to taking several medications at the same time.

When the temperature rises above 38 degrees, it is recommended to reduce it with medications using Panadol. This medicine reduces fever and relieves pain symptoms. The main component of the medicine: paracetamol, approved by WHO to relieve fever and eliminate pain.

Parents have no reason to worry when their children’s temperature rises sharply due to illness. High temperature causes the body to produce, which protects the body from viruses and bacteria, this is how the child’s body learns to cope with diseases.

Of course, there is no need to force the child to suffer if the high temperature causes inconvenience. Whether to give an antipyretic or not is determined by how the child feels. If he is weak, drowsy, capricious, does not feel well, feels pain, or signs of dehydration appear, it is better to bring down the temperature with Panadol or its analogues.

The main function of the product: lowering the temperature for colds and flu. With the help of Panadol, parents relieve fever when their children are sick with chickenpox, whooping cough, measles, rubella, scarlet fever, and other infections. Use it when , . Panadol is used for teething children.

The active component of the drug, paracetamol, is used to relieve fever after vaccinations. An important advantage of the medicine: the ability to use it for children from the third month of life. Paracetamol does not affect the water-salt metabolism of the child's body and the condition of the mucous membrane of the stomach and intestines.

Instructions for use and dosage

In pharmacy kiosks, Panadol is found in several forms. These include tablets, powder for preparing a solution, suppositories, syrup (suspension), and capsules. The form of medication taken by the patient depends entirely on the age, condition of the patient and sensitivity to the drug.

For young children, the medicine is available in several forms: suspension (syrup), rectal suppositories, tablets.

The suspension is used for oral use; it is bottled in 100 mg bottles. The syrup has a pleasant strawberry taste and aroma. The medicine box contains a measuring syringe and a dosage table, from which it is easy to understand how much the dosage will be depending on age and weight. After the child takes the antipyretic medicine (suspension), it acts within 20 minutes and remains effective for up to 3–4 hours.

The syrup is taken every 4–6 hours, depending on the severity of the disease. The syrup is given from the third month of life, which is convenient for the treatment of colds and infectious diseases in infants. The course without consulting a doctor is no more than 3 days. If the dose of medication is exceeded, it is recommended to consult a doctor.

Instructions for using Panadol are as follows:

For children aged 2–3 months, syrup can be given only on an individual prescription from a pediatrician;
For children 6–8 kg aged from three to six months, only 4 mg can be given once, the maximum daily dose for them will be 16 mg;
For a baby aged from six months to a year weighing from 8 to 10 kilograms, no more than 5 mg of syrup can be given at a time, and the maximum dosage per day cannot be more than 20 mg;
For children aged from one to two years, a single dose of medication is 7 mg, and the daily dose is 28 mg.

When treating fever and pain with suppositories, the recommended daily dose is no more than 4 pieces. Place Panadol suppositories 3-4 times every four to six hours. The effect of one candle reaches six hours. Suppositories are used when the child reaches six months of age. The therapeutic effect of the Panadol suppository begins 1–2 hours after rectal administration. The suppositories are administered rectally.

The medicine, produced in the form of tablets, is blisters designed for 6 and 12 tablets. The tablets themselves are white with embossing. Children are recommended to take tablets only from 6 years of age. The instructions say the maximum recommended dose per day is 4 tablets:

A child from 6 to 9 years old is recommended to take half a tablet (250 mg) 3-4 times a day, with an interval of at least 4 hours. They are allowed to take a maximum of 2 tablets per day;
A child from 9 to 12 years old is recommended to take one tablet 3-4 times a day; tablets should not be given more often than once every 4 hours.

Do not take the medicine for more than 5 days as a pain reliever and no more than 3 days as an antipyretic. Exceeding the dosage or increasing the course of treatment is permitted only by a doctor; you cannot increase the dosage of the medicine yourself.

When treated with metoclopramide, the rate of absorption of the active substance Panadol into the blood increases. Panadol enhances the effect of warfarin, possibly increasing the risk of bleeding. The use of barbiturates reduces the antipyretic effect of the active substance of the drug, possibly increasing the toxic effect of the liver. The antipyretic drug Panadol reduces the effect of diuretics.

Contraindications and side effects

Panadol is not recommended for use with other drugs containing paracetamol to avoid overdose;
The product should not be taken by children with kidney and liver diseases;
If the patient is given a concurrent course of rifampicin or treatment with anticonvulsants, there is a risk of toxicological liver damage;
The medicine is recommended to be used with caution in children under 3 months;
Panadol should not be used for children with fructose intolerance;
The medicine is not given to premature infants who are underweight;
Sometimes the drug causes a laxative effect.

Among the adverse reactions to the drug, doctors record allergic reactions in the form of rashes on the skin. They stop when the drug is discontinued within 24–48 hours. Side effects become fully apparent when the drug is overdosed. On the first day, pale skin, abdominal pain, nausea and vomiting occur. On the first or second day after an overdose, toxic damage to the kidneys and liver occurs, up to the development of liver failure, the consequences of which can be coma or death. Cardiac arrhythmia and pancreatitis may occur.

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In case of an overdose of the drug, immediate medical attention is necessary, even if the symptoms have not yet manifested themselves.

At home, the stomach is washed and prescribed. After exceeding the dosage, N-acetylcysteine or methionine is prescribed for 2 days. If necessary, the doctor prescribes an alpha-blocker as maintenance therapy. After an overdose, a period of increased sensitivity to iodine-containing drugs is possible.

Analogs

This medicine has many analogues that have antipyretic and analgesic effects. Analogue medications are developed on the basis of various substances (paracetamol, ibuprofen, etc.). For example, analogues of Panadol are drugs containing paracetamol:

Nurofen, the main substance of which is ibuprofen. Nurofen is available in the form of effervescent tablets, suppositories, and syrup. Nurofen is available in orange or strawberry flavors. The bottle of Nurofen syrup has protection against small patients so that the child does not open and drink the sweet syrup. It is also equipped with a plastic measuring syringe, which will help avoid overdose. The drug effectively copes with the reduction of fever during colds and infectious diseases, relieves pain of various origins.

Drug price

The price of Panadol depends on the trade markup of pharmacies, the region of the country in which the medicine was purchased and on the form of release. For example, the price of a medicine produced in the form of rectal suppositories varies from 66 rubles to 69 rubles. The syrup form of the medicine costs from 93 to 99 rubles, depending on the pharmacy chain, trade markup, and drug supplier. On average, the price of medicine in tablet form varies from 29 to 33 rubles. It is worth remembering that the delivery of medicine from an online pharmacy to the client is prohibited according to federal legislation on the circulation of medicines.

active substance: 5 ml of suspension contain 120 mg of paracetamol;

Excipients: malic acid, azorubine (E 122), xanthan gum, liquid maltitol, strawberry flavoring, sorbitol solution crystallizes, sodium ethyl parahydroxybenzoate (E 215), sodium propyl parahydroxybenzoate (E 217), sodium methyl parahydroxybenzoate (E 219), sorbitol (E 420), acid lemon anhydrous, purified water.

Dosage form

Oral suspension.

Basic physical and chemical properties: pink viscous liquid with the smell of strawberries, there are crystals in the suspension.

Pharmacotherapeutic group

Analgesics and antipyretics. Paracetamol.

ATX code N02B E01.

Pharmacological properties

Pharmacodynamics.

The analgesic and antipyretic effect of paracetamol is due to inhibition of prostaglandin synthesis and a predominant effect on the thermoregulation center in the hypothalamus.

Pharmacokinetics.

Paracetamol is well absorbed from the gastrointestinal tract. Peak plasma concentrations occur 20-30 minutes after administration. Metabolized in the liver to form paracetamol glucuronide and sulfate. It is excreted mainly by the kidneys. The half-life is from 1 to 4 hours.

Indications

Pain during teething, toothache, sore throat, fever due to colds, flu and childhood infections such as chickenpox, whooping cough, measles, mumps.

Contraindications

Hypersensitivity to any of the components of the drug.

Severe renal and/or liver dysfunction, congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency, alcoholism, blood diseases, severe anemia, leukopenia.

Patients with rare hereditary fructose intolerance.

Children's age up to 2 months.

Interaction with other drugs and other types of interactions

The rate of absorption of paracetamol may increase when used simultaneously with metoclopramide and domperidone and decrease when used with cholestyramine.

The anticoagulant effect of warfarin and other coumarins may be enhanced by concomitant long-term, regular daily use of paracetamol, with an increased risk of bleeding; intermittent use has no significant effect.

Barbiturates reduce the antipyretic effect of paracetamol.

Anticonvulsants (including phenytoin, barbiturates, carbamazepine), which stimulate the activity of microsomal liver enzymes, may increase the toxic effects of paracetamol on the liver due to an increase in the degree of conversion of the drug to hepatotoxic metabolites.

With the simultaneous use of paracetamol with hepatotoxic drugs, the toxic effect of the drug on the liver increases. The simultaneous use of high doses of paracetamol with isoniazid increases the risk of developing hepatotoxic syndrome.

Paracetamol reduces the effectiveness of diuretics.

Do not use simultaneously with alcohol.

Features of application

It is necessary to consult a doctor regarding the possibility of using the drug in patients with impaired renal and liver function.

Sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate and propyl parahydroxybenzoate may cause allergic reactions.

For children aged 2-3 months who were born prematurely, the drug can be used only according to the doctor’s recommendations.

The danger of overdose occurs in patients with non-cirotic alcoholic liver disease.

Do not use the drug in children together with other products containing paracetamol.

If the signs of the disease do not begin to disappear within 3 days of treatment with the drug or, on the contrary, your health condition worsens, you should consult a doctor.

Each 120 mg/5 ml of suspension contains 666.5 mg of sorbitol per 5 ml of suspension.

Do not exceed the indicated doses.

Keep the drug out of the reach of children

Use during pregnancy or breastfeeding

The ability to influence the reaction rate when driving a vehicle or working with other mechanisms

The drug is intended for use by children.

Directions for use and doses

Panadol ® Baby is intended for the treatment of children aged 2 months to 12 years.

The drug is intended for oral administration only.

The drug can be repeated every 4-6 hours if necessary. Do not take more than 4 doses per day. Do not take more than every 4 hours.

The maximum period of use of the drug without a doctor’s recommendation is 3 days.

For children aged 2-3 months. The child's body weight must be more than 4 kg. For symptomatic treatment of reactions to vaccination, use a single dose of 2.5 ml of suspension. If necessary, the dose can be repeated, but not earlier than after 4-6 hours. Do not give more than 2 doses. If the child's body temperature does not decrease after a second dose, you should consult a doctor. Further use of the drug in children of this age is possible only under the supervision of a doctor.

Children aged 3 months to 12 years. Find in the table the dose that corresponds to the child's age. Dosage table for paracetamol suspension 120 mg/5 ml for children:

For convenient dosing of the suspension, the measuring device marks from 0.5 to 8 ml. If you need to measure a dose that is more than 8 ml, measure out the first 8 ml of suspension and then the remainder of the dose.

Children

Use for children aged 2 months to 12 years.

Overdose.

With long-term use in high doses - aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia. When taken in high doses it may

develop dizziness, psychomotor agitation and disorientation, disturbances with

parts of the urinary system - nephrotoxicity (renal colic, interstitial nephritis, papillary necrosis).

Overdose is usually caused by paracetamol and is manifested by pale skin, anorexia, nausea, vomiting, abdominal pain, hepatonecrosis, increased activity of “liver” transaminases and an increase in the prothrombin index. In case of overdose, increased sweating, psychomotor agitation or depression of the central nervous system, drowsiness, impaired consciousness, cardiac arrhythmias, tachycardia, extrasystole, tremor, hyperreflexia, and convulsions may occur. Liver damage may appear 12-48 hours after an overdose. Impaired glucose metabolism and metabolic acidosis may occur. In severe poisoning, liver dysfunction can progress to encephalopathy with impaired consciousness, hemorrhage, hypoglycemia, cerebral edema, and in some cases, death. Acute renal dysfunction with acute tubular necrosis can manifest as severe lumbar pain, hematuria, proteinuria and develop even in the absence of severe liver damage. Cardiac arrhythmia and pancreatitis were also noted.

Liver damage is possible in adults who took more than 10 g and in children who took more than 150 mg/kg body weight. Taking 5 g or more of paracetamol may cause liver damage in patients with risk factors (long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. John's wort or other drugs that induce liver enzymes; regular intake of excessive amounts of ethanol; glutathione cachexia (disorders) digestion, cystic fibrosis, HIV infection, hunger, cachexia).

In case of overdose, emergency medical care is required. The patient should be taken to hospital immediately, even if there are no early symptoms of overdose. Symptoms may be limited to nausea and vomiting or may not reflect the severity of overdose or the risk of organ damage. Treatment with activated charcoal should be considered if an excessive dose of paracetamol has been taken within 1 hour. Plasma concentrations of paracetamol should be measured 4 hours or later after administration (earlier concentrations are unreliable). Treatment with N-acetylcysteine is applicable within 24 hours after taking paracetamol, but the maximum protective effect occurs when it is used within 8 hours after taking it. The effectiveness of the antidote decreases sharply after this time. If necessary, the patient is administered N-acetylcysteine intravenously according to the established list of doses. In the absence of vomiting, oral methionine may be used as an appropriate alternative in remote areas outside the hospital.

Adverse reactions

Adverse reactions to paracetamol are very rare (< 1/10 000):

from the blood and lymphatic systems- thrombocytopenia, bruising or bleeding, anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, shortness of breath, heart pain), hemolytic anemia, agranulocytosis;

from the immune system- anaphylaxis, hypersensitivity reactions, including itching, rashes on the skin and mucous membranes (usually erythematous, urticaria), angioedema, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome);

from the respiratory system- bronchospasm in patients sensitive to aspirin and other non-steroidal anti-inflammatory drugs;

from the digestive tract- nausea, epigastric pain, impaired liver function, increased activity of liver enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect);

from the endocrine system- hypoglycemia, up to hypoglycemic coma;

Aseptic pyuria.

The drug may have a slight laxative effect.