Folic acid tablets 1mg 50. Folic acid - instructions for use

Folic acid is required by a woman in a certain amount. It is involved in protein metabolism, which means that its deficiency will affect the state of the whole organism. This vitamin has the greatest influence on hematopoiesis and the neuroendocrine system. Folic acid is especially necessary for women after 40, since hormonal levels change at this age. Vitamin deficiency can exacerbate symptoms such as frequent flushing, emotional outbursts, and reduced performance.

Folic acid (vitamin B9) enters the body with food and is partially produced by the normal intestinal microflora.

Derivatives of folic acid are called folates. Folates are especially needed by rapidly dividing cells, which is why growing children and pregnant women need them to ensure proper growth and development of the fetus. The nervous system of the fetus can especially suffer from folate deficiency, so pregnant women are prescribed high doses of folate.

After 40 years, folic acid becomes even more important for a woman. This happens because the physiological process of hormonal changes in the body begins. Especially important is the fact that the secretion of estrogens, which supported the activity of not only the reproductive organs, but also the rest of the body, is reduced. The benefits of vitamin B9 are associated with its estrogen-like action.

How folate deficiency manifests itself

Folate is not stored in the body, so it needs to be replenished every day. More than half of women suffer from their deficiency. Most often this is due to:

• deficiency of vitamin B9 in the diet, as it is almost completely destroyed during the heat treatment of products;
• high need for folic acid in certain periods of life (during growth, pregnancy, menopause);
• violation of the absorption of folates in the intestine in various diseases of the digestive system.

The first symptoms of deficiency are loss of appetite, lethargy, weakness, inability to perform daily duties. The mood is also disturbed, the extreme manifestation of this symptom is depression. There is irritable weakness, tearfulness, insomnia at night and drowsiness during the day.

Prolonged deficiency of vitamin B9 leads to the development of megaloblastic anemia. The condition is associated with a violation of the maturation of red blood cells - erythrocytes. Immature giant erythrocytes are called megaloblasts and do not cope with their function of transfer to the organs and tissues of the body.

The disease manifests itself in the form of loss of appetite, nausea, vomiting, diarrhea, shortness of breath. Often stomatitis develops in the mouth - aphthous ulcers appear, gums bleed, hair falls out, nails become dull and brittle, memory is impaired, the ability to acquire new knowledge and skills.

All about vitamin B9 - in one video

What is the danger of hypovitaminosis B9 for women

In children and adolescents, vitamin deficiency manifests itself in a lag in growth and sexual development. In the second half of a woman's life, it can manifest itself in the form of an early menopause. Sometimes menopause begins on time (after 40 years), but proceeds with a number of unpleasant symptoms, then they talk about menopausal syndrome, which can develop against a background of folate deficiency.

The most dangerous is hypovitaminosis B9 during pregnancy. It is needed for the development of fetal nerve cells, which not only divide very quickly, but also acquire a certain specialization - they differentiate.

Deficiency is manifested by signs of a violation of the development of the brain in the fetus, which can be seen on ultrasound: swelling of the brain, an increase in the size of the head (hydrocephalus), underdevelopment or complete absence of the brain (microcephaly or anencephaly), the appearance of a crack in the spine, when the spinal cord of the fetus and outgoing from it the nerves remain uncovered (spina bifida,) and so on.

Sometimes the changes are not visible, but after birth the child lags behind in neuropsychic development. Against the background of vitamin B9 deficiency, the fetus may also develop other anomalies (heart defects, etc.).

Violations of the structure and function of the placenta are also possible. This can result in miscarriage and malnutrition of the fetus, as a result of which the brain suffers.

What is the danger of an overabundance of anti-anemic vitamin

If vitamins enter the body with food, their overdose is almost impossible. It is dangerous to take medicines and dietary supplements with folates for a long time.

Too much folate will cause vitamin B12 deficiency. This is manifested in the development of anemia and diseases of the peripheral nerves. Symptoms of an overdose of folic acid:

• nausea, vomiting, diarrhea, abdominal pain, unpleasant metallic taste in the mouth;
• the appearance of increased anxiety, nervous excitability;
• insomnia;
• various kinds of elements of a rash on the skin;
• sharp paroxysmal pains in the heart.

With an excess of folic acid, the risk of rapid progression of tumor processes also increases, since all rapidly dividing cells need folic acid. If there is no tumor, folates prevent its development, but already in a state of precancer, they stimulate tumor growth.

Folic acid for women over 40

Between the ages of 40 and 45, menopause begins. This condition is also called perimenopause and is divided into 3 periods: premenopause (from the onset of menopause to the last menstruation), menopause (last menstruation) and postmenopause (after menopause).

Menopause is accompanied by emotional disorders, instability of blood pressure (BP), frequent hot flashes, etc. Metabolism is disturbed, which manifests itself in postmenopause in the form of osteoporosis, atherosclerosis and related pathology.

Why do women need folic acid after 45:

• due to estrogen-like properties - it has an effect similar to the female sex hormones estrogen; this property allows, if not eliminated, then significantly smooth out such symptoms of premenopause as hot flashes, sweating, blood pressure drops, palpitations, etc .;
• increases mental and physical performance, improves mood, eliminates depression; this happens because B9 is involved in the exchange of such neurotransmitters (substances by which nerve impulses are transmitted) as the stress hormone adrenaline and the happiness hormone serotonin;
• suppresses skin aging, reduces dryness of mucous membranes.

Why do women need folic acid after 50:

• B9 has anti-atherosclerotic properties - it normalizes cholesterol metabolism, prevents the deposition of atherosclerotic plaques and related diseases of the circulatory system;
• prevents osteoporosis;
• stimulates the synthesis of blood cells;
• stimulates the immune system, thus suppressing infections and oncological processes.

Vitamin B9 for Women's Health

The benefits of folate for a woman are invaluable: children and adolescents grow, their cells are intensively dividing. With a deficiency of folic acid, the girl lags behind in physical, mental and sexual development.

The impact of B9 on a woman of childbearing age is enormous. Under its influence, the neuroendocrine system functions correctly, on the state of which the health and appearance of a woman depends. During pregnancy, it is needed to carry the fetus.

When the physiological aging process begins, folates reduce the manifestations of menopausal syndrome. After 50 years, folic acid for women is a protection against such consequences of metabolic disorders as osteoporosis, atherosclerosis, type 2 diabetes, etc.

Produce folic acid in tablets of 1 mg. For treatment, doctors prescribe large dosages of the drug (up to 5 mg per day). For prevention, 200 mcg per day (a fifth of the tablet) is enough. You need to take a vitamin once a day.

Folic acid and beauty

Vitamin B9 preserves the beauty and youth of a woman. The cells of the skin epithelium are constantly updated, the skin is rejuvenated. Reproduction of epithelial cells occurs by division with the participation of folic acid.

B9 is also involved in protein metabolism, as a result of which collagen and elastin proteins are formed in fibrocytes (connective tissue cells located in the deep layers of the skin), giving the skin a firm, fresh look and elasticity.

How much folic acid does a woman need

The daily requirement of women for folic acid:

• 11 - 14 years old - 150 mcg;
• 15 years old and over forty years old - 200 mcg;
• pregnant women - 400 mcg;
• lactating mothers - 300 mcg.

Interaction of folic acid with vitamins and minerals

Folic acid supplementation works well with most vitamins and minerals. But before you start taking vitamins, you should consult your doctor and find out their compatibility. Compatibility of B9 with other vitamins and minerals:

• B12 (cyanocobalamin) - perfectly combined, complementing the action (but with long-term use folic acid deficiency develops cyanocobalamin and as a result - severe pernicious anemia);
• B6 (pyridoxine) - goes well and helps prevent atherosclerosis; prolonged B6 deficiency leads to B9 deficiency;
• B3 (nicotine, PP) - compatible;
• C (ascorbic) - perfectly combined, with ascorbic B9 it is better absorbed;
• E (tocopherol) - a neutral combination;
• A (retinol) - a neutral combination;
• D (calciferol) is a neutral combination.

Folic acid is not compatible with:

• B2 (riboflavin) - with this combination, B9 quickly decomposes;
• zinc - an insoluble precipitate is formed that is not absorbed into the blood.

What foods contain B9

A feature of the folates contained in the products is the impossibility of an overdose. Therefore, during menopause in the diet you need to have the following products:

• garden greens, especially parsley (115 mcg / 100 g), dill and leek feathers, asparagus (260 mcg / 100 g);
• vegetables - cabbage (30 mcg / 100 g), carrots, pumpkin, beets, tomatoes (45 mcg / 100 g);
• legumes - beans, lentils, beans (160 mcg / 100 g);
• cereals - wheat (50 mcg / 100g), rye, buckwheat, corn;
• nuts - most of all in peanuts (240 mcg / 100 g);
• seeds - sunflower, pumpkin, sesame;
• fruits - most of all in citrus fruits (30 mcg / 100 g);
• berries - raspberries, currants, strawberries, watermelons (30 mcg / 100 g);
• animal liver (up to 240 mcg/100 g);
• fish liver;
• eggs.

Vitamin B9 is essential for a woman's body. A woman especially needs this vitamin during pregnancy and menopause. It protects women from the unpleasant symptoms of menopause and from the consequences of metabolic disorders characteristic of this period.

LS-002261-270214

Trade name of the drug:

Folic acid

International non-proprietary name:

folic acid

Dosage form:

pills.

Compound:

for 1 tablet:
active substance: folic acid - 1 mg
Excipients: lactose monohydrate (milk sugar) - 72.20 mg, microcrystalline cellulose - 18.80 mg, povidone (polyvinylpyrrolidone) - 2.00 mg, corn starch - 5.00 mg, magnesium stearate - 1.00 mg.

Description:

Pale yellow to yellow tablets with a score on one side and a chamfer on both sides. The presence of blotches of a darker and lighter color is allowed.

Pharmacotherapeutic group:

vitamin

ATX code:

B03BB01

Pharmacological properties

Pharmacodynamics

Vitamin B group (vitamin Bs, vitamin B 9) can be synthesized by the intestinal microflora. In the body, folic acid is reduced to tetrahydrofolic acid, which is a coenzyme that serves as an acceptor of one-carbon radicals. Participates in the synthesis of purine and pyrimidine bases, the metabolism of certain amino acids (for example, the interconversion of serine and glycine), the biosynthesis of the methyl radical of methionine and the degradation of histidine, as well as in the maturation of rapidly proliferating tissues, especially blood and the gastrointestinal tract. Folic acid deficiency leads to megaloblastic anemia; with folic acid deficiency in the first trimester of pregnancy, the development of the nervous system of the fetus is disrupted.

Pharmacokinetics
Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the proximal small intestine. It is restored in the lumen of the gastrointestinal tract, circulates in the blood mainly in the form of 5-methyltetrahydrofolic acid. The time to reach maximum plasma concentration is 30-60 minutes.
Intensively binds to plasma proteins. Penetrates through the blood-brain barrier, placenta and breast milk.
It is deposited and metabolized in the liver.
Excreted by the kidneys mainly as metabolites; if the dose taken significantly exceeds the daily requirement for folic acid, then it is excreted unchanged. Removed by hemodialysis.

Indications for use

• Treatment and prevention of anemia due to folic acid deficiency, including insufficient dietary intake, malabsorption, increased need (including pregnancy, lactation, hemolytic anemia, hyperthyroidism, exfoliative dermatitis or chronic infections).
• Prevention of folic acid deficiency during pregnancy and lactation.

Contraindications

Hypersensitivity to the components of the drug.
B 12 - deficiency anemia.
Lactose intolerance, lactase deficiency or glucose-galactase malabsorption.
Children's age up to 3 years.
Carefully

Folate-dependent malignancies, the use of dihydrofolate reductase inhibitors (eg, methotrexate).

Use during pregnancy and during breastfeeding

It is possible to use the drug throughout pregnancy and lactation.

Dosage and administration

Inside, after eating.
Megaloblastic anemia: adults and children over 3 years old - 1-5 mg / day. The duration of treatment depends on the severity of the disease and is based on the dynamics of the content of red blood cells and hemoglobin in the blood.
To prevent folic acid deficiency during pregnancy and lactation, take 0.5 mg 1 time per day.

Side effect

allergic reactions: rash, itching, erythema, bronchospasm, hyperthermia, anaphylactic reactions.
From the gastrointestinal tract: anorexia, nausea, bloating, bitter taste in the mouth, diarrhea.
From the side of the nervous system: irritability, sleep disturbance.
Others: with prolonged use, the development of hypovitaminosis B 12 is possible.

Overdose

Taking the drug at a dose of 15 mg for one month did not cause signs of overdose.

Interaction with other drugs

Folic acid can reduce the concentration of phenytoin and barbiturates in the blood.
Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid. During treatment, antacids should be used 2 hours after taking folic acid, cholestyramine - 4-6 hours before or 1 hour after taking folic acid.
Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead of it, patients using these drugs should be given calcium folinate).

special instructions

For the prevention of hypovitaminosis of folic acid, a balanced diet is most preferable. Foods rich in folic acid - lettuce, spinach, tomatoes, carrots, fresh liver, legumes, beets, eggs, cheese, nuts, cereals.
The drug is not used to treat anemia due to other causes than folic acid deficiency.
In megaloblastic anemia due to vitamin B 12 deficiency, folic acid, by improving hematological parameters, may mask neurological complications. Until megaloblastic anemia is excluded, the appointment of folic acid in doses exceeding 0.4 mg / day is not recommended (with the exception of pregnancy and lactation).
Patients on hemodialysis require increased amounts of folic acid.
Antibiotics can distort (deliberately underestimate) the results of microbiological assessment of the concentration of folic acid in plasma and erythrocytes. When using large doses of folic acid, as well as therapy for a long period, a decrease in the concentration of vitamin B 12 in the blood is possible.

Influence on the ability to drive vehicles and mechanisms

Folic acid intake does not affect the ability to drive vehicles and engage in potentially hazardous activities that require increased concentration and psychomotor speed.

Release form

Tablets 1 mg.
10, 50 tablets in a blister pack made of polyvinyl chloride film and printed lacquered aluminum foil.
10, 20, 30, 40, 50, or 100 tablets in polymer jars for medicines.
One jar or 1, 2, 3, 4, 5, 6, 8 or 10 blister packs together with instructions for use are placed in a carton (pack).

Storage conditions

In a dry, dark place at a temperature not exceeding 25°C.
Keep out of the reach of children.

Best before date

3 years.
Do not use after the expiration date.

Holiday conditions

Over the counter.

Manufacturer

OOO "Ozon"

Legal address:
445351, Russia, Samara region, Zhigulevsk, st. Pesochna, 11

Address of the place of production (address for correspondence, including for receiving claims):
445351, Russia, Samara region, Zhigulevsk, st. Gidrostroiteley, d. 6

folic acid group.

Compound

The active substance is folic acid.

Manufacturers

Akrikhin KhPK (Russia), Borisov Plant of Medical Preparations (Belarus), Valenta Pharmaceuticals (Russia), Darnitsa Pharmaceutical Firm (Ukraine), Marbiopharm OJSC (Russia), Ozon LLC (Russia), Technologist (Ukraine), Technologist SKTB Ministry of Education (Russia) , Schelkovsky vitamin plant (Russia)

pharmachologic effect

Replenishing folic acid deficiency, hematopoietic.

In the body, it is converted to tetrahydrofolic acid, which is necessary for the creation of megaloblasts and their transformation into normoblasts.

With its deficiency, a megaloblastic type of hematopoiesis develops.

It occupies an important place in the metabolism of purines and pyrimidines, the synthesis of nucleic acids, the metabolism of amino acids (glycine, methionine and histidine).

After ingestion, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is absorbed in the upper part of the duodenum.

Almost completely bound to plasma proteins.

Cmax in the blood is reached in 30-60 minutes.

It is excreted by the kidneys both unchanged and as metabolites.

Side effect

Allergic reactions:

• bronchospasm,
• erythema,
• fever,
• skin rashes.

Indications for use

Treatment of folic acid deficiency, including against the background of unbalanced and malnutrition.

Prevention of the development of neural tube defects in the fetus in the first trimester of pregnancy.

Treatment and prevention of anemia, against the background of folic acid deficiency, macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, post-resection anemia, anemia associated with diseases of the small intestine, sprue and malabsorption syndrome.

Contraindications

Hypersensitivity to the components of the drug, pernicious anemia, malignant neoplasms, cobalamin deficiency.

Method of application and dosage

Apply inside after meals.

To prevent the development of neural tube defects in the fetus in the first trimester of pregnancy - 1 mg per day.

For therapeutic purposes:

• adults 1-2 mg per day.

Depending on the condition, the dose may be increased to 5 mg per day.

Overdose

No data.

Interaction

Sharing with analgesics, anticonvulsants, antacids, cholestyramine, sulfonamides, antibiotics, cytostatics reduces the effect.

special instructions

No data.

Storage conditions

List B.

In a dry, dark place, at room temperature.

Composition and form of release
tablets 1 mg, 50 pcs. packaged

pharmachologic effect
Replenishes folic acid deficiency, stimulates erythropoiesis.

Folic acid - folacin, water-soluble folate, vitamin B9. In the body, it is converted into tetrahydrofolic acid, which is necessary for the maturation of megaloblasts and their transformation into normoblasts. With its deficiency, a megaloblastic type of hematopoiesis develops. It occupies an important place in the metabolism of purines and pyrimidines, the synthesis of nucleic acids, the metabolism of amino acids (glycine, methionine and histidine). After ingestion, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is absorbed in the upper part of the duodenum. Almost completely bound to plasma proteins. It undergoes activation in the liver under the influence of the enzyme dihydrofolate reductase, turning into tetrahydrofolic acid. Cmax in the blood is reached in 30-60 minutes. It is excreted by the kidneys both unchanged and as metabolites.

Indications
Megaloblastic anemia, sprue, drug and radiation anemia and leukopenia, post-resection anemia, chronic gastroenteritis, intestinal tuberculosis, folic acid deficiency.
Prevention of folic acid deficiency in the body (including during pregnancy and lactation).

Contraindications
Hypersensitivity to folic acid.
Folic acid can be used during pregnancy and lactation at the recommended doses.

Dosage and administration
For medicinal purposes adults - 5 mg / day; children - in smaller doses depending on age. The course of treatment is 20-30 days.
To prevent folic acid deficiency in the body is used in doses of 20-50 mcg / day.

The daily requirement for folic acid is for children 1-6 months - 25 mcg, 6-12 months - 35 mcg, 1-3 years - 50 mcg, 4-6 years - 75 mcg, 7-10 years - 100 mcg, 11- 14 years - 150 mcg, 15 years and older - 200 mcg.
During pregnancy- 400 mcg / day, during lactation - 300 mcg / day.

Side effect
Allergic reactions: bronchospasm, erythema, fever, skin rashes.

special instructions
In pernicious anemia, folic acid should only be used in conjunction with cyanocobalamin, since folic acid, by stimulating hematopoiesis, does not prevent the development of neurological complications (including funicular myelosis). Long-term use of folic acid (especially in high doses) is not recommended due to the risk of reducing the concentration of cyanocobalamin in the blood.

drug interaction
With simultaneous use with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid decreases.
With simultaneous use, folic acid reduces the effects of phenytoin, primidone, PAS, sulfasalazine, hormonal contraceptives for oral administration, chloramphenicol.
Folic acid increases the metabolism of phenytoin.

Storage conditions
In a dry, dark place, at a temperature not exceeding 25 ° C

Best before date: 3 years.

Flat-cylindrical tablets, with a bevel, from pale yellow to yellow. Minor blotches of yellow are allowed.

Active ingredients

Brand

Release form

Pills

Pharmacological effect

Vitamin B group (vitamin Bc, vitamin B9) can be synthesized by the intestinal microflora. In the body, folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.

Contraindications

Hypersensitivity to the components of the drug, B12 deficiency anemia, sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, children under 3 years of age.

Use during pregnancy and lactation

Considering that folic acid deficiency is especially dangerous in the first weeks of pregnancy, this vitamin is recommended to be taken in preparation for pregnancy, as well as during the entire period of bearing a baby, 1 mg daily. For therapeutic purposes, the dose can be increased to 5 mg per day. High doses of folic acid in the period of preparation for pregnancy and in the first third of it are also prescribed to women who have already had cases of the birth of children with folate-dependent malformations.

Dosage and administration

inside. Folic deficiency anemia: adults and children of any age, the initial dose is 1 mg / day. At high doses, resistance may occur. Maintenance treatment: for newborns - 0.1 mg / day, for children under 4 years old - 0.3 mg / day, for children over 4 years old and adults - 0.4 mg / day, during pregnancy and lactation - 0.8 mg / day, but not less than 0.1 mg / day. With hypo- and avitaminosis of folic acid (depending on the severity of avitaminosis), adults - up to 5 mg / day, children - in smaller doses, depending on age. The course of treatment is 20 - 30 days. With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, after gastrectomy, malabsorption syndrome, with liver failure, cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.

Side effects

Allergic reactions - skin rash, pruritus, bronchospasm, erythema, hyperthermia.

Overdose

Doses of folic acid up to 4-5 mg are well tolerated. Higher doses may cause central nervous system and gastrointestinal disturbances.

Interaction with other drugs

Anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid. Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid. Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (instead of it, patients using these drugs should be given calcium folinate).

special instructions

For the prevention of hypovitaminosis of folic acid, a balanced diet is most preferable. Foods rich in folic acid - green vegetables (lettuce, spinach), tomatoes, carrots, fresh liver, legumes, beets, eggs, cheese, nuts, cereals. Folic acid is not used to treat B12-deficient, normocytic and aplastic anemia. With B12 - deficiency anemia, folic acid, improving hematological parameters, masks neurological complications. Until B12 deficiency anemia is ruled out, the appointment of folic acid in doses exceeding 0.1 mg / day is not recommended (with the exception of pregnancy and lactation).