Antigrippin instruction blue and red capsules. Antigrippin maximum and the rules for its use

Antigrippin Maximum is medicinal product intended for the treatment of acute respiratory diseases containing an increased amount active components.

What is the maximum composition and form of release of Antigrippin?

Antigrippin Maximum is available in two types of capsules: type P and type P. The former contain paracetamol as active substance, 360 mg per dosage form.

Auxiliary components: pharmaceutical pregelatinized starch, colloidal silicon dioxide, lactose monohydrate, magnesium stearate. The capsule shell consists of: medical gelatin, titanium dioxide and blue food coloring.

Among auxiliary components it should be noted the presence of such compounds as: purified potato starch and magnesium stearate. The shell is made from the following substances: red food dye, titanium dioxide and pharmaceutical gelatin.

Capsules of both types have a size number 0, are quite hard, their contents are a white powder. The drug is available in blisters, and each type is in its own packaging. In addition to this dosage form Antigrippin Maximum is also produced in the form of a powder containing all the active substances mentioned above. The drug can be purchased at any pharmacy without a doctor's prescription.

What is the maximum pharmacological action of Antigrippin?

Antigrippin Maximum, as you already understood, is complex drug, and therefore the range of their effects is quite extensive. First of all, it has an antipyretic effect, as well as antiviral, anti-inflammatory, interferonogenic, analgesic, angioprotective and antihistamine. I will briefly review each component separately.

Paracetamol causes the provision of antipyretic and analgesic effect. This circumstance is dictated by the ability of this drug to block a special enzyme, cyclooxygenase, which is involved in the processes of prostaglandin biosynthesis. After that, the processes of thermogenesis are suppressed.

Rimantadine is an antiviral substance that can block the reproduction of type A influenza viruses. It has practically no effect on pathogens of type B diseases, however, experts say that there is a mild antitoxic effect. In addition, this substance is able to stimulate the production of interferons - compounds that can suppress the sensitivity of body cells to viral proteins.

Ascorbic acid has long been known as a non-specific stimulant defensive reactions, a means capable of reducing vascular permeability, as well as a strong stimulant of redox reactions.

Loratadine is a histamine blocker, a drug that reduces swelling of tissues, and as a result, normalizes the well-being of patients.

Rutozid is an angioprotector designed to suppress vascular permeability and strengthen the walls of arterioles. As a result, the swelling of the affected area decreases, the rate of platelet aggregation decreases, blood circulation normalizes, and so on. Calcium gluconate has a similar effect to this drug.

What are the maximum indications for Antigrippin?

The use of the drug Antigrippin Maximum is indicated only in the following cases:

Treatment of type A influenza in adult patients;
Symptomatic treatment of acute respiratory diseases in patients over 18 years of age.

Attention should be drawn, despite the fact free sale, it will be useful to get qualified advice from a specialist, and go through comprehensive examination. Remember, the flu is extremely dangerous for its complications, including myocarditis and other life-threatening conditions.

What are the maximum contraindications for Antigrippin?

The appointment of Antigrippin Maximum is not carried out in the presence of the following circumstances:

peptic ulcer and duodenum;
Bleeding from the gastrointestinal tract;
Pathology thyroid gland;
Hemorrhagic diathesis;
hypercalcemia;
Organ pathology excretory system;
Hypoprothrombinemia;
Urolithiasis disease;
Syndrome portal hypertension;
Chronic alcoholism;
Hypercalciuria;
Individual intolerance;
lactation period;
The patient's age is less than 18 years;
Pregnancy;
The use of cardiac glycosides.

What is the maximum use and dosage of Antigrippin?

Antigrippin Maximum should be consumed only after meals. Capsules are allowed the right amount ordinary water. As a rule, patients are prescribed one capsule of each type three times a day, until the symptoms of the disease disappear.

What are the maximum side effects of Antigrippin?

At Antigrippin Maximum, the instructions for use highlight quite a lot of such effects.

From the side digestive system, especially when long-term use: erosive lesion mucous membrane upper divisions digestive tract, dry mouth, loss of appetite, increased gas formation, diarrhea.

From the central and peripheral nervous system: sleep disorders, tremor of the limbs, headache, dizziness, weakness, flushes of blood to the skin of the face and some others.

Other unwanted manifestations: allergic reactions, lesions of the insular apparatus of the pancreas, pollakiuria and some others.

What are the maximum analogues of Antigrippin?

AT this moment time full structural analogues funds Antigrippin Maximum does not exist. Consult a doctor for the selection of a drug that has a similar pharmacological effect.

Conclusion

To protect yourself and your loved ones from colds, you need to follow some simple rules. First, you should dress warmly. Secondly, avoid crowded places, and thirdly, eat a balanced diet and regularly be in the fresh air.

◊ Capsules two kinds.

Capsules P hard gelatin, of blue color, size #0; the contents of the capsules are a mixture of powder and / or granules of white or white with a creamy or pinkish tint, granules irregular shape, different size, the presence of lumps is allowed.

Excipients: pregelatinized starch 9 mg, lactose monohydrate 4.2 mg, magnesium stearate 3.8 mg, colloidal silicon dioxide 3 mg.

The composition of the capsule shell: gelatin 94.795 mg, patent blue dye (E131) 0.265 mg, titanium dioxide (E171) 1.94 mg.

Capsules P hard gelatinous, red, size No. 0; the contents of the capsules are a mixture of powder and / or granules of yellow with a greenish tinge and white color, irregularly shaped granules of different sizes, lumps are allowed.

Excipients: potato starch 2.2 mg, magnesium stearate 4.8 mg.

The composition of the capsule shell: gelatin 94.064 mg, iron dye yellow oxide (E172) 0.97 mg, iron dye red oxide (E172) 0.485 mg, crimson dye (Ponso 4R) (E124) 0.511 mg, titanium dioxide (E171) 0.97 mg.

20 pcs. (10 caps. P in a separate package of cellular contour (1) and 10 caps. R in a separate package of cellular contour (1)) - packs of cardboard.

◊ Powder for oral solution [lemon, lemon with honey, raspberry, blackcurrant] in the form of a mixture of almost white granules with a greenish-yellowish powder, with a characteristic odor; the prepared solution is colorless or with a yellowish tint, slightly cloudy, with a characteristic odor (lemon, lemon with honey, raspberries, black currants), undissolved yellow particles are allowed.

Excipients: aspartame 30 mg, hypromellose 10 mg, colloidal silicon dioxide 20 mg, lactose 4086 mg, food flavor (lemon or lemon with honey, or raspberry or blackcurrant) 21 mg.

5 g - bags of combined material (3) - packs of cardboard.
5 g - bags of combined material (6) - packs of cardboard.
5 g - bags of combined material (8) - packs of cardboard.
5 g - bags of combined material (12) - packs of cardboard.
5 g - bags of combined material (24) - packs of cardboard.

The description of the drug is based on official instructions for use and approved by the manufacturer.

pharmachologic effect

Combined drug with antiviral, interferonogenic, antipyretic, anti-inflammatory, analgesic, antiallergic and angioprotective action.

Paracetamol has antipyretic, analgesic and anti-inflammatory action.

rimantadine - antiviral agent, is active against influenza type A virus. By blocking the M 2 channels of influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting critical stage virus replication. Induces the production of interferons alpha and gamma. In influenza caused by the B virus, rimantadine has an antitoxic effect.

Vitamin C participates in the regulation of redox processes, normalizes capillary permeability, blood clotting, tissue regeneration, activates the immune system.

Loratadine- a blocker of histamine H 1 receptors, prevents the development of tissue edema associated with the release of histamine.

Rutozid- angioprotector. Reduces the increased permeability of capillaries, reducing its swelling and inflammation, strengthens vascular wall. It has antiplatelet action and increases the degree of deformation of erythrocytes.

calcium gluconate prevents the development of increased permeability and fragility of blood vessels, which cause hemorrhagic processes in influenza and SARS, and also restores capillary circulation and has an anti-allergic effect (the mechanism is unclear).

Pharmacokinetics

Paracetamol

Absorption is high. According to the results of the clinical research when taking capsules, Cmax of paracetamol in blood plasma is reached after 1.2 ± 0.72 hours and is 5.01 ± 1.7 μg / ml, T 1/2 is 3.04 ± 1.01 hours.

Plasma protein binding - 15%. Penetrates through the BBB.

It is metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercaptopuric acid. The main isoenzymes of cytochrome P450 for this way metabolism are isoenzyme CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). In glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Paracetamol conjugated metabolites (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.

It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

In elderly patients, the clearance of the drug decreases and T 1/2 increases.

rimantadine

After oral administration, it is almost completely absorbed from the intestine. Absorption is slow. According to the results of clinical studies, when taking capsules, Cmax in blood plasma is reached after 4.53±2.52 hours and is 68.2±26.6 ng/ml; T 1/2 is 30.51 ± 9.83 hours.

Plasma protein binding is about 40%. V d - 17-25 l / kg. The concentration in the nasal secretion is 50% higher than the plasma concentration.

Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - unchanged.

In chronic renal failure T 1/2 increases by 2 times. In patients with renal insufficiency and in elderly patients, it can accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in CC. Hemodialysis has little effect on the clearance of rimantadine.

Vitamin C

Ascorbic acid is absorbed from the gastrointestinal tract (mainly in the jejunum). Plasma protein binding - 25% . The concentration of ascorbic acid in plasma is normally approximately 10-20 μg / ml. T max in blood plasma after ingestion is 4 hours. It easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye. Penetrates through the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in plasma. At scarce states leukocyte concentration declines later and more slowly and is considered a better predictor of deficiency than plasma concentration.

It is metabolized mainly in the liver to deoxyascorbic acid and then to oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat in unchanged form and in the form of metabolites.

Diseases of the gastrointestinal tract ( peptic ulcer stomach and duodenum, constipation or diarrhea, helminthic invasion, giardiasis), drinking fresh fruit and vegetable juices, alkaline drink reduce the absorption of ascorbic acid in the intestine.

Smoking and the use of ethanol accelerate the destruction of ascorbic acid (transformation into inactive metabolites), sharply reducing stocks in the body. Excreted during hemodialysis.

Loratadine

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. According to the results of clinical studies, when taking capsules, C max in blood plasma is reached after 2.92 ± 1.31 hours and is 2.36 ± 1.53 ng / ml, T 1/2 is 12.36 ± 6.84 hours.

Plasma protein binding - 97%. It is metabolized in the liver to form an active metabolite of descarboxyloratadine with the participation of cytochrome CYP3A4 isoenzymes and, to a lesser extent, CYP2D6. Does not penetrate the BBB.

It is excreted by the kidneys and with bile.

In elderly patients, C max increases by 50%.

In patients with chronic renal failure and during hemodialysis, the pharmacokinetics practically does not change.

Rutozid

Tmax in blood plasma after oral administration is 1-9 hours. It is excreted mainly with bile and, to a lesser extent, by the kidneys. T 1/2 - 10-25 hours

calcium gluconate

Approximately 1/5-1/3 of orally administered calcium gluconate is absorbed into small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) - through the intestines.

Indications

Etiotropic treatment of type A influenza in adults;

Symptomatic treatment colds, influenza and SARS, accompanied by fever, muscle pain, headache, chills in adults.

Dosing regimen

The drug should be taken orally after meals.

Adults Antigrippin-maximum in capsules appoint 1 capsule P blue and 1 capsule R red 2-3 times / day until the symptoms of the disease disappear. Capsules are washed down with water.

Adults and children over 12 years old Antigrippin-maximum in shape powder for oral solution apply 1 sachet 2-3 times / day until the symptoms of the disease disappear. Preparation of the solution: dissolve the contents of 1 sachet in 1 glass of boiled water. hot water. Use hot, after stirring.

The duration of the course of treatment is 3-5 days (no more than 5 days). If within 3 days after the start of the drug, there is no improvement in well-being, the patient should stop taking the drug and consult a doctor.

Side effect

From the side of the central nervous system: rarely - irritability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing.

From the digestive system: possibly (with a duration of use of more than 7 days) - damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

From the hematopoietic system: possibly (with a duration of use of more than 7 days) - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

From the urinary system: moderate pollakiuria is possible.

allergic reactions: rarely - skin rash, itching, urticaria.

Others: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).

In case of appearance side effects the patient should immediately stop taking the drug and consult a doctor.

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;

Gastrointestinal bleeding;

Hemophilia;

Hemorrhagic diathesis;

Hypoprothrombinemia;

Vitamin K deficiency;

Thyroid diseases;

Acute and exacerbation of chronic kidney disease (incl. acute glomerulonephritis, acute pyelonephritis);

kidney failure;

nephrourolithiasis;

Acute and exacerbations of chronic liver diseases (incl. acute hepatitis);

portal hypertension;

chronic alcoholism;

hypercalcemia;

Severe hypercalciuria;

Sarcoidosis;

Simultaneous reception of cardiac glycosides (risk of arrhythmia);

Lactose intolerance, lactase deficiency, glucose-galactose malabsorption;

Pregnancy;

lactation period (breastfeeding);

Children's and adolescence up to 18 years (for capsules);

Hypersensitivity to the components of the drug.

FROM caution use the drug for epilepsy, cerebral atherosclerosis, diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (history), mild to moderate hypercalciuria; in elderly patients with arterial hypertension(increased risk of developing hemorrhagic stroke, due to rimantadine, which is part of the drug).

In the presence of the diseases or conditions listed above, the patient should consult a doctor before taking the drug.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

special instructions

With prolonged use (more than 7 days), an exacerbation of chronic concomitant diseases is possible, in elderly patients with arterial hypertension, the risk of developing hemorrhagic stroke increases (due to rimantadine hydrochloride, which is part of the drug).

Persons prone to alcohol consumption should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

The drug should not be used in the presence of metastatic tumors.

Antigrippin-maximum does not have carcinogenic properties.

Pediatric use

The drug in the form of a powder should not be prescribed children under the age of 12.

The drug in the form of capsules is contraindicated children and adolescents under the age of 18.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, patients should be careful when driving vehicles and other potentially dangerous species activities requiring high concentration attention and speed of psychomotor reactions.

Overdose

Symptoms: possible pallor in the first 24 hours skin, nausea, diarrhea, vomiting, pain in epigastric region, impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma; acute kidney failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: the introduction of donators of the SH group and precursors of the synthesis of glutathione - methionine within 8-9 hours after an overdose and acetylcysteine - within 8 hours. symptomatic therapy. The need for additional therapeutic measures(further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

In case of an overdose of the drug, the patient needs to consult a doctor.

drug interaction

If necessary, the simultaneous use of Antigrippin-Maximum with other drugs, the patient should consult a doctor.

Paracetamol

Reduces the effectiveness of uricosuric medicines.

Concomitant use of paracetamol in high doses enhances the effect of anticoagulant drugs.

Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose.

At simultaneous application with metoclopramide, an increase in the rate of absorption of paracetamol is possible.

Prolonged use of barbiturates reduces the effectiveness of paracetamol.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxic effects of paracetamol.

Vitamin C

Increases plasma concentration of benzylpenicillin.

Improves the absorption of iron preparations in the intestines (converts ferric iron to ferrous). May increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of crystalluria in the treatment of salicylates and sulfonamides short action, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have alkaline reaction(including alkaloids).

Reduces the concentration in the blood of oral contraceptives.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

With simultaneous use reduces the chronotropic effect of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces therapeutic effect antipsychotic drugs(neuroleptics) phenothiazine derivatives.

Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.

rimantadine

Enhances the stimulating effect of caffeine.

Cimetidine reduces the clearance of rimantadine by 18%.

Loratadine

Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in plasma.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 2 years.

Combined drug with antiviral, interferonogenic, antipyretic, anti-inflammatory, analgesic, antiallergic and angioprotective action.

Paracetamol has antipyretic, analgesic and anti-inflammatory effects.

Rimantadine is an antiviral agent that is active against type A influenza virus. By blocking the M 2 channels of influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of interferons alpha and gamma. In influenza caused by the B virus, rimantadine has an antitoxic effect.

Ascorbic acid is involved in the regulation of redox processes, normalizes capillary permeability, blood clotting, tissue regeneration, activates the immune system.

Loratadine - a blocker of histamine H 1 receptors, prevents the development of tissue edema associated with the release of histamine.

Rutozid is an angioprotector. Reduces the increased permeability of capillaries, reducing its swelling and inflammation, strengthens the vascular wall. It has antiplatelet action and increases the degree of deformation of erythrocytes.

Calcium gluconate prevents the development of increased vascular permeability and fragility, which cause hemorrhagic processes in influenza and SARS, and also restores capillary circulation and has an antiallergic effect (the mechanism is unclear).

Pharmacokinetics

Paracetamol

Absorption is high. According to the results of clinical studies, when taking capsules, Cmax of paracetamol in blood plasma is reached after 1.2±0.72 hours and is 5.01±1.7 µg/ml, T 1/2 is 3.04±1.01 hours.

Plasma protein binding - 15%. Penetrates through the BBB.

It is metabolized in the liver in three main ways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine and mercaptopuric acid. The main cytochrome P450 isoenzymes for this metabolic pathway are the CYP2E1 isoenzyme (mainly), CYP1A2 and CYP3A4 (a minor role). In glutathione deficiency, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Paracetamol conjugated metabolites (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.

It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

In elderly patients, the clearance of the drug decreases and T 1/2 increases.

rimantadine

Plasma protein binding is about 40%. V d - 17-25 l / kg. The concentration in the nasal secretion is 50% higher than the plasma concentration.

Metabolized in the liver. More than 90% is excreted by the kidneys within 72 hours, mainly in the form of metabolites, 15% - unchanged.

Vitamin C

Ascorbic acid is absorbed from the gastrointestinal tract (mainly in the jejunum). Plasma protein binding - 25%. The concentration of ascorbic acid in plasma is normally approximately 10-20 μg / ml. T max in blood plasma after ingestion is 4 hours. It easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye. Penetrates through the placental barrier. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in plasma. In deficient states, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration.

Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbic acid in the intestine.

Smoking and the use of ethanol accelerate the destruction of ascorbic acid (transformation into inactive metabolites), sharply reducing stocks in the body. Excreted during hemodialysis.

Loratadine

It is excreted by the kidneys and with bile.

In elderly patients, C max increases by 50%.

In patients with chronic renal failure and during hemodialysis, the pharmacokinetics practically does not change.

Tmax in blood plasma after oral administration is 1-9 hours. It is excreted mainly with bile and, to a lesser extent, by the kidneys. T 1/2 - 10-25 hours

calcium gluconate

Approximately 1/5-1/3 of orally administered calcium gluconate is absorbed in the small intestine; this process depends on the presence of ergocalciferol, pH, dietary characteristics and the presence of factors capable of binding calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) - through the intestines.

Release form

Capsules of two types.

Capsules P hard gelatinous, blue, size No. 0; the contents of the capsules are a mixture of powder and / or granules of white or white with a creamy or pinkish tint, granules of irregular shape, different sizes, lumps are allowed.

Excipients: pregelatinized starch, lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

The composition of the capsule shell: gelatin, proprietary blue dye (E131), titanium dioxide (E171).

Capsules P hard gelatinous, red, size No. 0; the contents of the capsules are a mixture of powder and / or granules of yellow with a greenish tint and white, irregularly shaped granules of different sizes, lumps are allowed.

Excipients: potato starch, magnesium stearate.

The composition of the capsule shell: gelatin, iron dye yellow oxide (E172), iron dye red oxide (E172), crimson dye (Ponso 4R) (E124), titanium dioxide (E171).

20 pcs. (10 caps. P in a separate package of cellular contour (1) and 10 caps. R in a separate package of cellular contour (1)) - packs of cardboard.

Dosage

The drug should be taken orally after meals.

For adults, Antigrippin-maximum capsules are prescribed 1 capsule P blue and 1 capsule P red 2-3 times / day until the symptoms of the disease disappear. Capsules are washed down with water.

For adults and children over 12 years of age, Antigrippin-maximum in the form of a powder for oral solution is used 1 sachet 2-3 times a day until the symptoms of the disease disappear. Preparation of the solution: dissolve the contents of 1 sachet in 1 cup of boiled hot water. Use hot, after stirring.

Overdose

Symptoms: in the first 24 hours, pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region, impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases are possible. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: administration of SH-group donors and glutathione synthesis precursors - methionine within 8-9 hours after an overdose and acetylcysteine - within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

In case of an overdose of the drug, the patient needs to consult a doctor.

Interaction

If necessary, the simultaneous use of Antigrippin-Maximum with other drugs, the patient should consult a doctor.

Paracetamol

Reduces the effectiveness of uricosuric drugs.

The concomitant use of paracetamol in high doses enhances the effect of anticoagulant drugs.

With simultaneous use with metoclopramide, an increase in the rate of absorption of paracetamol is possible.

Prolonged use of barbiturates reduces the effectiveness of paracetamol.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxic effects of paracetamol.

Vitamin C

Increases plasma concentration of benzylpenicillin.

Improves the absorption of iron preparations in the intestines (converts ferric iron to ferrous). May increase iron excretion when used concomitantly with deferoxamine.

Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids).

Reduces the concentration in the blood of oral contraceptives.

Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

With simultaneous use reduces the chronotropic effect of isoprenaline.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) phenothiazine derivatives.

Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.

rimantadine

Enhances the stimulating effect of caffeine.

Cimetidine reduces the clearance of rimantadine by 18%.

Loratadine

Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in plasma.

Side effects

From the side of the central nervous system: rarely - irritability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing.

On the part of the digestive system: it is possible (with a duration of use of more than 7 days) - damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

On the part of the hematopoietic system: it is possible (with a duration of use of more than 7 days) - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia.

From the urinary system: moderate pollakiuria is possible.

Allergic reactions: rarely - skin rash, itching, urticaria.

Others: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).

In the event of side effects, the patient should immediately stop taking the drug and consult a doctor.

Indications

etiotropic treatment of influenza type A in adults;
symptomatic treatment colds, flu and SARS, accompanied by fever, muscle pain, headache, chills in adults.

Contraindications

erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
gastrointestinal bleeding;
hemophilia;
hemorrhagic diathesis;
hypoprothrombinemia;
vitamin K deficiency;
thyroid disease;
acute and exacerbation of chronic kidney diseases (including acute glomerulonephritis, acute pyelonephritis);
kidney failure;
nephrourolithiasis;
acute and exacerbations of chronic liver diseases (including acute hepatitis);
portal hypertension;
chronic alcoholism;
hypercalcemia;
severe hypercalciuria;
sarcoidosis;
simultaneous reception of cardiac glycosides (risk of arrhythmia);
lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
pregnancy;
lactation period (breastfeeding);
children and adolescents under 18 years of age (for capsules);
hypersensitivity to the components of the drug.

The drug is used with caution in epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, calcium nephrourolithiasis (in history) , mild to moderate hypercalciuria; in elderly patients with arterial hypertension (the risk of developing hemorrhagic stroke increases due to rimantadine, which is part of the drug).

In the presence of the diseases or conditions listed above, the patient should consult a doctor before taking the drug.

Application features

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindicated in acute or exacerbations chronic diseases liver (including acute hepatitis) and portal hypertension.

Application for violations of kidney function

Contraindicated in acute and exacerbation of chronic kidney disease (including acute glomerulonephritis) and in renal failure.

Use in children

The drug is prescribed for children over 12 years of age.

special instructions

Persons prone to alcohol consumption should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

The drug should not be used in the presence of metastatic tumors.

Antigrippin-maximum does not have carcinogenic properties.

Pediatric use

The drug in the form of a powder should not be administered to children under the age of 12 years.

The drug in the form of capsules is contraindicated in children and adolescents under the age of 18 years.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, patients should be careful when driving vehicles and other potentially hazardous activities that require a high concentration of attention and speed of psychomotor reactions.

Latin name: Antigrippin Maximum
ATX code: J05A X
Active substance: paracetamol,
ascor. to-ta, rimantadine, loratadine,
calcium gluconate, rutoside
Manufacturer: Antiviral (Russia)
Pharmacy leave condition: Without recipe

Antigrippin Maximum is a multicomponent agent used to treat influenza and acute viral diseases in adults. Renders fast action due to the content of an increased concentration of therapeutic components.

Indications for use

The drug is used to treat influenza "A" in adult patients, as well as symptomatic remedy to eliminate pain during colds, flu and SARS (high fever, muscle and headaches, fever).

The composition of the drug

Capsules are available in two types with different content of medicinal components:

Blue: in 1 pill - one active substance paracetamol in the amount of 0.36 g. The components of the filling and shell are pregelatinized starch, lactose (in the form of monohydrate), magnesium stearate, aerosil.

Red capsules. One pill contains several active ingredients:

Askor. to-ta - 0.3 g
Calcium gluconate (monohydrate) - 0.1 g
Rimantadine (as hydrochloride) - 0.05 g
Rutoside (as trihydrate) - 0.02 g
Loratadin - 0.003 g.

Other ingredients: potato starch, magnesium stearate. Shell components: gelatin, dyes (E172, E124), E171.

Soluble powder. Contents of 1 sachet includes:

Paracetamol - 0.36 g
Ascorbin. to-ta - 0.3 g
Calcium gluconate (as monohydrate) - 0.1 g
Rimantadine (in the form of hydrochloride) - 0.05 g
Rutozid - 0.02 g
Loratadin - 0.003 g.

Additional ingredients that provide the structure of drugs are aspartame, hypromellose, lactose, aerosil, fragrance (lemon, honey, raspberry, black currant).

Medicinal properties

The therapeutic effect is achieved by the action of all constituent components of Antigrippin Maximum:

Paracetamol relieves fever, pain, reduces the intensity of the inflammatory process.
Rimantadine suppresses viral infection, activates the production of α- and γ-interferons. Helps reduce toxins in the body that are formed during the flu.
Acorbic acid ensures the correct implementation of redox processes, normalizes the state of blood vessels, strengthens capillaries, accelerates tissue repair, and supports immunity.
Loratadine relieves swelling caused by allergic reaction organism.
Rutozid eliminates the increased permeability of blood vessels and capillaries, reducing swelling and inflammation.
Calcium gluconate protects blood vessels from injury, normalizes blood circulation in capillaries, counteracts the development of allergies.

Release form

The average price is 259 rubles.

Antigrippin is produced in the form of capsules and powder for the preparation of a medicinal drink.

Capsules - a set of blue and red pills placed in separate blisters:

Type P: pills in a blue hard gelatin body. Filling - a mixture of powder and irregularly shaped granules. The mixture can be of different shades - white, whitish, pinkish or pale beige. Possible education soft lumps are considered acceptable, not a defect.
Type P: hard capsules in a red gelatin body. The filling of the pills is of a similar type and structure.

Each type of capsules is packaged in a separate blister of 10 pieces. In a pack of cardboard - 2 plates (one of each type), instructions for use.

Price: (1 pc.) - 221-305 rubles. (3 pcs.) - 94-115 rubles. (6 pcs.) - 152-164 rubles. (12 pcs.) - 253-283 rubles. (24 pcs.) - 395 rubles.

Powder for cooking medicinal solution produced in various flavors. It has the appearance of a greenish-cream or yellowish mixture of granules and powder, characteristic odor. The reconstituted liquid is colorless or with a slightly yellowish tint and slightly cloudy. The presence of a small amount of undissolved suspension is allowed. Depending on the type of fragrance, it smells like lemon, blackcurrant, raspberry or honey.

The medicinal powder is packaged in separate 5 mg sachets. The number of sachets in a carton package is 3.6, 8, 12 or 24 pcs. Each pack with a set of sachets is accompanied by instructions for use.

Mode of application

Drink Antigrippin Maximum instructions for use advise after eating.

Capsules. Single dosage for people over 18 years old - 2 capsules (blue and red). They are taken together, washed down copious amounts water. Depending on the severity of the condition, the medicine is allowed to drink 2-3 times a day. The course is determined individually, it is recommended to drink drugs until the signs of the disease disappear completely.

Antigrippin Maximum powder is diluted in water before administration. Single dosage - 1 sachet. The resulting liquid is drunk 2-3 times a day until signs of remission. To achieve a more complete therapeutic effect, it is recommended to take the medicine hot. The duration of the therapeutic course is from 3 to 5 days. It is not recommended to exceed the upper limit. If the state of health has not improved after 3 days of taking the drug, you should contact your doctor. You cannot increase the dosage on your own.

During pregnancy and breastfeeding

Antigrippin Maximum is prohibited for use in the treatment of pregnant women. Nursing women can be treated with the drug only if they refuse lactation.

Contraindications

Antigrippin is prohibited to take with:

Individual increased reaction of the body to the components of drugs
Exacerbation of ulcers and erosions of the gastrointestinal tract
Bleeding in the gastrointestinal tract
bleeding problems, hemophilia
Diseases of the thyroid gland
Lack of phylloquinone in the body (Vit. K)
Renal failure, exacerbation chronic pathologies kidney
Acute kidney disease
If you have kidney stones
alcohol addiction
Elevated plasma calcium concentration
Sarcoidosis
Pregnancy and breastfeeding
Lactose intolerance, congenital lactase deficiency, glucose-galactose malabsorption syndrome.

In addition, the medicine should not be taken by patients taking cardiac glycosides. Antigrippin-Maximum capsules are prohibited for children and adolescents under 18 years of age, powder - up to 12 years of age.

Great care requires the appointment of the drug to patients suffering from:

diabetes mellitus
epilepsy
atherosclerosis
Thalassemia
Hypercalciuria in mild or moderate severity.

If these or other accompanying illnesses or any drugs are taken, then, in order to avoid unforeseen side effects, the attending physician should be informed about this.

Precautionary measures

During treatment with Antigrippin Maximum, the following should be taken into account:

Too long a course (more than 1 week) contributes to the exacerbation of existing chronic diseases, in elderly patients with high blood pressure, the risk of hemorrhagic stroke increases.
People with alcohol addiction should consult a doctor before taking Antigrippin, since paracetamol, which is part of the drug, worsens the condition and functioning of the liver.
Cancer patients who have metastases should refrain from taking the drug.
People involved in transport or management complex mechanisms, care must be taken. Antigrippin can cause drowsiness or distraction, which will affect the speed of reaction and concentration.

Cross-drug interactions

The use of Antigrippin Maximum in any form should take into account the ability of its components to react with compounds of other drugs. Therefore, if the patient is taking any other medications, he should consult a doctor about correct combination Antigrippin with these medicines. Otherwise, mutual distortion of therapeutic actions and the development of unpredictable reactions of the body are possible.

Features of the interaction of Antigrippin Maximum are due to the properties of its active components.

Paracetamol:

When combined with anti-gout drugs reduces their effectiveness.
When taken in high doses, it enhances the effect of anticoagulants.
When combined with Rifampicin, Phenylbutazone, tricyclic antidepressants, alcohol-containing drugs or drinks, it enhances them toxic effect on the liver. As a result, the risk of overdose increases.
The action is enhanced when combined with Metoclopramide.
Long-term use of barbiturates reduces healing effect paracetamol.

Vitamin C:

Promotes an increase in plasma levels of benzylpenicillin.
Enhances the absorption of iron-containing drugs.
When combined with drugs containing deferoxamine, it accelerates the removal of iron from the body.
At joint admission with salicylates or sulfonamides, it inhibits the work of the kidneys to remove acids, drugs with alkaloids from the body.
Reduces the effectiveness of oral contraceptives.
It enhances the excretion of ethanol from the body, but at the same time the concentration of acid decreases.
The excretion of vitamin C is accelerated by the action of barbiturates and Primidone.
Reduces therapeutic effect neuroleptics based on phenothiazines.

Rimantadine:

Enhances the stimulating effect of caffeine.
The clearance of the substance is reduced when combined with Cimetidine.

Loratadine. Its plasma concentration increases under the influence of CYP3A4 and CYP2D6 inhibitors.

Side effects

Subject to the admission rules unwanted effects usually do not develop. However, during treatment with Antigrippin Maximum, the appearance of adverse reactions body:

Increased irritability, excitability
Sleep disturbance, lethargy, drowsiness
Head pain
Dizziness
Spontaneous muscle movements
Tremor
Skin reactions (in the form of rash, itching, urticaria)
Disruption of the insular apparatus
Frequent urination.

In case of prolonged use (more than a week), Antigrippin Maximum can provoke:

Damage to the mucous tissues of the gastrointestinal tract
Dry mouth
Accumulation of gases in the gastrointestinal tract
Violation of the stool (diarrhea)
Changes in the composition of the blood.

The attending physician should be informed about the development of these or other uncharacteristic symptoms. Cancel antigrippin.

Overdose

Careless or deliberate use of overdoses of Antigrippin Maximum leads to the development of intoxication of the body. Symptoms of an overdose are characterized by the properties of the components included in the drug. Signs of intoxication depend on how much time has passed after ingestion. On the first day, usually observed:

Paleness, blueness of the skin
Headaches, vertigo
Nausea
Diarrhea
Bouts of vomiting
Pain in the epigastrium
Tachycardia
Failure of glucose metabolism, development of acidosis
Exacerbation of existing chronic diseases.

2 days after the last dose of Antigrippin, there are violations in the liver, which manifest themselves in varying degrees depending on the amount of drugs drunk. In the case of the development of a severe form of intoxication, liver failure develops, followed by encephalopathy, coma.

To alleviate the condition, health care. The stomach is cleaned (lavage), symptomatic treatment. If necessary, drugs are administered to accelerate the withdrawal of Antigrippin.

Terms and conditions of storage

Drugs can be treated for 2 years from the date of production, provided proper storage. To avoid damage to drugs, they must be kept in places protected from sunlight, sources of heat and moisture. The temperature should not exceed 25 °C. Keep away from children!

Analogues

To eliminate pain with flu, colds or SARS, you can use other medications. Which of them can replace Antigrippin-Maximum - the doctor or pharmacist will advise.

Nearmedic Plus (Russia)

Price:(12 pcs.) - 227 rubles.

The drug suppresses microbial and viral infection, enhances immunity, stimulates the body to produce its own interferon. The action of drugs is achieved due to the active substance of the same name - kagocel.

After the penetration of the substance into the body, the production of interferon improves various types. As a result, recognition and destruction of the infection is accelerated.

The drug is produced in tablets. Approved for use from the age of 3, it is prescribed for the treatment and prevention of influenza, SARS. Also used in the treatment herpetic infection in adults.

Pros:

Helps well
Strengthens immunity.

Flaws:

Valenta Pharm (Russia)

Price: 60 mg (7 pcs.) - 396 rubles, 90 mg (7 pcs.) - 478 rubles.

The antiviral agent is intended for the treatment of influenza, SARS and adenovirus infection. The active ingredient of the drug is Vitaglutam. The substance inhibits the reproduction of pathogens and at the same time activates the production of interferon.

The drug is taken with slightest symptoms ailments - as early as possible, preferably within the first 36 hours. In this case therapeutic effect guaranteed.

Antiviral drugs are produced in capsules with different content medicinal substance- 60 or 90 mg. The first form is designed to treat children from 7 years of age, the second - for adults.

Ingavirin practically does not cause side effects and overdose. Reception schedule - 1 capsule per day for 5 to 7 days.

Pros:

Increases the body's resistance
Stimulates the immune system
Improves condition quickly.

Flaws:

You can not drink during pregnancy.

Antigrippin Maximum is available in the form of capsules of two different types(capsules P and capsules R) with different composition and in the form of a powder for preparation medicinal syrup. In the photo - capsules in blisters, taken out of the package:

And here is one sachet of powder:

Type P capsules contain only paracetamol, which provides antipyretic, analgesic and some anti-inflammatory effect.

The composition of capsules P includes:

Rimantadine is a substance that has previously been successfully used as an effective antiviral component. Today, almost all strains of influenza worldwide are resistant to it, and therefore antiviral action capsules have only against viruses tick-borne encephalitis and herpes simplex;
Ascorbic acid is a component necessary for quick recovery immunity during recovery after SARS. Therapeutic action does not provide, cannot protect against infection with a viral infection;
Loratadine is a powerful antiallergic agent that prevents the development of side effects from other components;
Rutozid - a substance with some anti-inflammatory properties, the effectiveness of which in humans has not been proven;
Calcium gluconate, like ascorbic acid, supports the restoration of the body, especially the nervous system, during the recovery period.

The powder for the preparation of the solution is a mixture of the components of capsules P and capsules R - it includes paracetamol, rimantadine, ascorbic acid, loratadine, rutoside and calcium gluconate.

On a note

A complete analogue of the drug is AnviMax. It not only contains the same active ingredients and has the same effect, but also completely copies the package design of Antigrippin Maximum, is produced in the same forms and has a similar cost.

What effect does the remedy have?

In all forms, Antigrippin Maximum provides an antipyretic and analgesic effect due to the action of paracetamol. Only capsules P taken separately do not bring down the temperature (they do not contain paracetamol), but such separate use of them does not correspond to the instructions.

With pronounced pain syndrome Antigrippin relieves pain, including headache, caused by general intoxication of the body.

By supplying the body with ascorbic acid from Antigrippin, the remedy supports the restoration of immunity during recovery. However, the therapeutic effect of ascorbic acid has not been confirmed and it is impossible to say that it has any therapeutic effect.

In general, Antigrippin Maximum is guaranteed to affect only the symptoms of the disease and therefore can be used not only for influenza and other viral infections, but also in bacterial and fungal diseases simply as an antipyretic and mild analgesic.

Does Antigrippin Maximum suppress the infection, does it slow down the development of the disease and does it speed up recovery?

In the descriptions and instructions, Antigrippin Maximum is positioned as a means for the etiotropic treatment of influenza, that is, one that affects the infection itself. This is due to the fact that the preparation contains rimantadine, a substance that has been used for a long time as an antiviral agent.

Indeed, at the time of development, rimantadine was effective, allowed to suppress the development of influenza and reduce the duration of the disease. However, this substance has been used since 1968 around the world, as a result of which flu strains resistant to it began to appear quite quickly. In 2011, studies showed that 100% of influenza strains that occur in humans are resistant to rimantadine, which means that today this substance does not affect the flu at all. Herpes simplex viruses and tick-borne encephalitis virus retain sensitivity to it, but the agent cannot act on the influenza virus.

As a result, consider Antigrippin Maximum as a drug that can affect the development flu infection in the body is not possible. You should not expect that this tool will help suppress the virus and shorten the duration of the disease.

Is it possible to use Antigrippin Maximum for the prevention of influenza and SARS?

Antigrippin Maximum does not have a preventive effect.

Rimantadine from its composition does not act on influenza viruses and is not able to prevent infection of the body and the development of infection.

Ascorbic acid only supports normal condition immunity and does not provide specific protection from influenza viruses. At the same time, normal immunity is not a reliable guarantee that influenza infection will not occur: if the body encounters a previously unknown strain of the virus, even with very good immunity disease will begin.

Other components of the drug affect only the symptoms of SARS and, in principle, cannot have a preventive effect. Antigrippin Maximum does not protect against infection with influenza.

On a note

At the same time, the tool has a strong physiological action- sedative, antipyretic and analgesic. For healthy person such effects are harmful, and therefore it is dangerous to drink the remedy without showing symptoms of the disease.

How is Antigrippin Maximum better than plain Antigrippin?

Virtually nothing. Regular also contains paracetamol and ascorbic acid, it also contains the anti-allergic component chlorphenamine. Compared with it, Antigrippin Maximum contains three additional component with a different effect - rimantadine, calcium gluconate and rutoside, the significance of which in ARVI is not so significant.

Instructions for use of capsules Antigrippin Maximum

Two types of capsules Antigrippin Maximum should be used simultaneously. One capsule P and one capsule P should be swallowed after meals with water.

The official instructions for use indicate normal frequency taking the drug 2-3 times a day for adults and adolescents over 12 years old. The same instructions indicate that the drug is taken until the symptoms of the disease disappear. This means that you need to take it when you develop severe symptoms- temperature above 38°С, severe pain throat, migraine. If after the next intake of capsules or powder such symptoms appear, after 5-6 hours it makes sense to take a new portion of the remedy. While there are no such symptoms - the temperature is kept within subfebrile values, and sore throats, in principle, are tolerable - the use of Antigrippin Maximum is inappropriate.

Antigrippin Maximum can be taken alone for no more than 5 days. If after 3 days after the start of its use there are no signs of improvement in the patient's condition, it is required mandatory consultation doctor because of the risk of developing complications of the disease.

How to apply the powder correctly?

Powder Antigrippin Maximum from one sachet is dissolved in a glass of warm boiled water and drunk warm after meals. Like capsules, it should be taken only when the patient has the appropriate symptoms - sore throat and heat. In their absence, taking the powder is not recommended.

Prices for different drugs Antigrippin Maximum

The price of a package of Antigrippin Maximum for 20 capsules (10 capsules P and 10 capsules R) is approximately 290 rubles.

Packaging Antigrippin Maximum in the form of a powder for 6 bags of 5 grams costs about 170 rubles. At the same time, there are several drugs on sale with different tastes - raspberry, lemon, blackcurrant. The prices of these funds are the same. The photo below shows a package of lemon flavored powder:

Also on sale are packages for 24 bags at a price of 450 rubles. In the photo - such a box:

From a financial point of view, capsules are more economical, but due to differences in packaging, sachets are more rational to buy. Capsules from one package are enough for 10 doses, which means that the price of the product for one dose will be about 29 rubles. Powders from one package are enough for 5 doses, each dose will cost about 34 rubles. The effectiveness of a powder from one sachet is the same as the effectiveness of two capsules - P and R - together. However, in case of illness, an adult may not need 10 doses of the remedy, and the whole package of capsules will be too much. 6 sachets of powder allow you to more accurately "guess" the amount of the required product.

Contraindications of the drug

Antigrippin Maximum in all forms is contraindicated in children under 12 years of age, pregnant women and breastfeeding mothers. It is allowed to take both children and pregnant women only P capsules, since they contain only paracetamol, but in this case they are cheaper and easier to replace a simple preparation paracetamol.

Capsules should not be taken by children and adolescents under 18 years of age.

Also, Antigrippin Maximum cannot be used for certain diseases, including:

Hemophilia;
Hemorrhagic diathesis;
stomach or intestinal ulcer;
Various internal bleeding, including those associated with a lack of vitamin K in the body;
Kidney disease and associated renal failure;
Acute liver diseases;
Thyroid disease;
Hypercalcemia and hypercalciuria;
Sarcoidosis;
chronic alcoholism;
portal hypertension;
hypothrombinemia;
Lactose intolerance.

Also, Antigrippin Maximum should not be taken with concomitant use of cardiac glycosides due to possible development severe arrhythmias.

In addition, there is a large number of diseases in which the drug can be prescribed only at the direction of a doctor - diabetes, sideroblastic anemia, hemochromatosis, hyperoxaluria and others. With the development of acute respiratory viral infections against their background, consultation with a specialist before taking Antigrippin Maximum is mandatory.

What side effects can develop when taking this drug?

Due enough complex composition Antigrippin Maximum can cause many side effects. Among them:

headaches, drowsiness or excitability, dizziness;
Skin rashes, urticaria;
Hyperglycemia, glucosuria;
Agranulocytosis, leukopenia, thrombocytopenia, anemia;
Diarrhea, flatulence, dyspepsia.

If any of these effects occur, Antigrippin Maximum should be discontinued. There are a large number of funds on sale that can provide similar action with significantly higher security.

Antigrippin Maximum is, in fact, an antipyretic and anti-inflammatory drug that makes sense to take with ARVI for symptomatic therapy. Its antiviral component does not act on influenza viruses today, but preventive action the drug is very limited, and therefore it can be used only for the purpose of temporary relief of the patient's condition.