Isoprinosine diarrhea. Isoprinosine: proven antiviral activity

In this medical article, you can read drug Isoprinosine. The instructions for use will explain in which cases you can take syrup and tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Isoprinosine, from which you can find out if the medicine helped in the treatment of influenza, herpes, HPV (human papillomavirus), as well as others colds in adults and children, for which it is also prescribed. The instructions list Isoprinosine analogues, drug prices in pharmacies, as well as its use during pregnancy.

Isoprinosine is a complex medicinal antiviral and immunostimulating agent. Instructions for use indicate that syrup and 500 mg tablets are prescribed for the treatment of diseases caused by herpes viruses.

Release form and composition

The drug Isoprinosine is available in dosage form tablets for oral (oral) intake. They have an elongated shape, biconvex surface, White color and a slight amine smell. On one side of the tablet, a separating line is applied. The main active ingredient of the drug is inosine pranobex, its content in the 1st tablet is 500 mg.

Isoprinosine tablets are packaged in a blister of 10 pieces. A cardboard pack contains 2, 3 or 5 blisters and instructions for using the drug.

Isoprinosine can be found in the form of an almost colorless clear syrup with a slight plum odor. The liquid is supplied to pharmacies in 150 ml glass bottles. The bottle is placed in a cardboard box, the kit includes a measuring spoon for easy dosing.

pharmachologic effect

Active ingredient Isoprinosine (inosine pranobex) has an immunostimulating and antiviral effect on the body. This substance blocks the reproduction various viruses also reduces symptoms viral infections.

Isoprinosine helps speed up recovery. This drug increases the body's resistance to mumps, measles and various herpes viruses (Varicella-Zoster, Epstein-Barr).

Indications for use

What is Isoprinosine good for? Tablets 500 mg and syrup are prescribed:

• with HPV of the genitals in women and men and in therapy for getting rid of warts;
• human papillomavirus infection (HPV), including papillomas vocal cords and larynx, fibrous type;
• therapy of the influenza virus and other acute respiratory viral infections;
• Infectious mononucleosis, due to the herpes virus type 4 (Epstein-Barr virus);
• molluscum contagiosum;
• infectious diseases that were caused by the herpes virus type 1, 2, 3, 4 and 5 (in Lately there was evidence of effectiveness in the treatment of herpes types 6, as well as types 7 and 8), labial herpes, genital herpes and herpetic keratitis;
• cytomegalovirus infection caused by the herpes virus type 5;
• measles (with severe course diseases);
• chicken pox, shingles.

Instructions for use

Isoprinosine tablets are taken after meals, without big amount water. Recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg of body weight in 3-4 doses, which averages for adults - 6-8 tablets per day, for children - 1/2 tablet per 5 kg of body weight per day.

At severe forms infectious diseases, the dose may be increased individually up to 100 mg/kg of body weight per day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g per day, for children aged 3 years and older - 50 mg / kg per day.

The duration of treatment for acute diseases in adults and children aged 3 years and older, it usually ranges from 5 to 14 days. Treatment must be continued until the disappearance clinical symptoms and for another 2 days already in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

In chronic relapsing diseases in adults and children aged 3 years and older treatment it is necessary to continue with several courses of 5-10 days with a break in admission of 8 days. For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

For recurrent genital warts, adults are prescribed 2 tablets 3 per day, children aged 3 years and older - 1/2 tablet per 5 kg / body weight per day in 3-4 doses, either as monotherapy or in combination with surgical treatment within 14-28 days, then with a threefold repetition of the specified course at intervals of 1 month.

At herpetic infection adults and children aged 3 years and older, the drug is prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period - 1 tablet 2 times a day for 30 days to reduce the number of relapses.

In case of papillomavirus infection, adults are prescribed 2 tablets 3 times a day, children aged 3 years and older - 1/2 tablet per 5 kg / body weight per day in 3-4 doses for 14-28 days as monotherapy.

For babies aged 1 to 3 years, it is more convenient to take the drug in the form of a syrup. The recommended dose in this case is 1 ml per 1 kg of body weight. little patient. The attending physician adjusts the amount of medication depending on individual features baby's body.

Contraindications

Isoprinosine according to the instructions is contraindicated in:

• Arrhythmias.
• Gout.
• Urolithiasis.
• Hypersensitivity to the components of Isoprinosine.
• Chronic renal failure.
• Tablets are not prescribed for children under 3 years of age (or with a body weight of less than 15 kg).

Side effects

After taking Isoprinosine tablets, negative reactions from various bodies and systems, which include:

• Musculoskeletal system - pain in the joints, exacerbation of the course of gout.
• Nervous system - headache, dizziness, sometimes may develop general weakness, drowsiness or insomnia.
• Urinary system - polyuria (increased volume of urine excreted during the day).
• Skin - severe itching.
• Digestive system - nausea, vomiting, pain in the stomach (epigastrium), less often diarrhea or constipation may develop.
• Liver and biliary tract - a reversible increase in the activity of liver transaminase enzymes (ALT, AST) in the blood, indicating damage to liver cells, an increase in plasma urea concentration.

Appearance side effects And negative reactions is the basis for discontinuation of the drug.

Children, during pregnancy and lactation

Safety of using Isoprinosine during pregnancy and during breastfeeding not installed. Tablets are not prescribed in childhood up to 3 years (body weight up to 15-20 kg).

special instructions

Before you start using Isoprinosine tablets, you should carefully read the instructions. There are several special instructions Things to watch out for include:

The drug does not have a direct effect on the speed of psychomotor reactions and the ability to concentrate.

After taking Isoprinosine tablets for 2 weeks, it is advisable to conduct a laboratory control of the level uric acid in blood.

It is necessary to carry out additional monitoring of the level of uric acid in the blood when joint application Isoprinosine tablets with drugs that increase its level.

In case of using the drug for more than 1 month, laboratory monitoring of indicators is necessary. functional activity liver.

drug interaction

Uricosuric drugs (including diuretics), as well as xanthine oxidase inhibitors, increase the risk of an increase in serum uric acid concentration during Isoprinosine therapy. Immunosuppressants reduce the effectiveness of the drug.

Isoprinosine is a modern antiviral drug that has an additional pronounced immunomodulatory effect.

Among all the drugs that are used in the fight against infectious pathologies viral origin, this drug occupies a special place. It is prescribed not only for banal bronchitis or SARS, but is also used in therapy malignant neoplasms, severe immunodeficiency states and are used as rehabilitation therapy after serious illnesses. Isoprinosine is produced pharmaceutical companies Portugal and Israel, so the price of the drug is quite high.

On this page you will find all the information about Isoprinosine: complete instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Isoprinosine. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Immunostimulating drug.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Isoprinosine cost? average price in pharmacies is at the level of 650 rubles.

Release form and composition

Isoprinosine is available in only one form, which is almost white tablets that have a slight amine odor. They are distinguished by an oblong convex shape and the presence of a risk on one of the sides, along which the preparation can be divided into halves. One blister includes 10 tablets, and one pack may contain from 2 to 5 blisters.

• Each tablet contains 500 mg active substance inosine pranobex.
• Excipients - wheat starch, mannitol, magnesium stearate, povidone. 10 tablets in a blister, 2, 3, 5 blisters in a cardboard box.

Isoprinosine does not have such dosage forms as a suspension, powder, dragee, syrup, capsules or injections.

Pharmacological effect

Isoprinosine is a synthetic derivative of purine. The active component of the drug - inosine pranobex stimulates the immune system and has a non-specific antiviral effect, blocking the reproduction of harmful viruses and alleviating the symptoms of viral diseases. Isoprinosine destroys the genetic apparatus of pathogenic microorganisms and restores the activity of lymphocytes in conditions of reduced immunity.

The drug is active against herpes virus, measles, influenza, cytomegalovirus, polioviruses, human cellular lymphoma virus. The drug increases the body's resistance to mumps, equine encephalitis, papilloma, encephalomyocarditis viruses.

Isoprinosine, when taken orally, is absorbed from the gastrointestinal tract and reaches a maximum in the blood plasma after 1-2 hours. At the same time, the drug does not accumulate in the body, it is metabolized and completely excreted by the kidneys within 2 days.

Indications for use

What helps? Isoprinosine is indicated for most viral diseases, the main ones being:

1. Viral hepatitis;
2. severe course;
3. stressful situations;
4. advanced age;
5. Radiation therapy;
6. Treatment of influenza and others;
7. Sclerosing panencephalitis (subacute);
8. Viral respiratory infections, incl. viral;
9. Chronic infectious diseases of the urinary and respiratory systems;
10. Viral infections in patients with normal immune status and in immunodeficiency states;
11. mucous membranes, skin, including papillomavirus infection of the vagina, vulva, cervix, genital warts.

In autumn and spring, when the body is especially prone to viral infections, the doctor may recommend taking isoprinosine for prophylaxis for those patients who often get sick during these periods.

Contraindications

Isoprinosine tablets are contraindicated for use if a person has the following diseases or conditions:

1. Pregnancy;
2. Urolithiasis disease;
3. The period of breastfeeding;
4. Chronic kidney failure;
5. Children under 3 years of age or body weight less than 15 kg;
6. Individual intolerance or allergic reactions to the components of the drug.

Use during pregnancy and lactation

Since the safety of the drug has not been proven against developing fetus And baby, it is not recommended for pregnant and breastfeeding women.

Instructions for use

The instructions for use indicate that Isoprinosine tablets are taken after meals with a small amount of water.

• The recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg / kg of body weight in 3-4 doses (for adults - 6-8 tablets / day, for children - 1/2 tablet per 5 kg of body weight / day).
• In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg body weight / day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g / day, for children - 50 mg / kg / day.

The duration of treatment for acute diseases in adults and children is usually from 5 to 14 days. Treatment should be continued until the disappearance of clinical symptoms and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

In chronic recurrent diseases in adults and children, treatment should be continued in several courses of 5-10 days with a break in admission of 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg / day (1-2 tablets) for 30 days.

1. With papillomavirus infection for adults, the drug is prescribed 2 tab. 3 times / day, children - 1/2 tab. per 5 kg / body weight / day in 3-4 doses for 14-28 days as monotherapy.
2. In case of herpetic infection for adults and children, the drug is prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period - 1 tab. 2 times / day for 30 days to reduce the number of relapses.
3. With cervical dysplasia associated with the human papillomavirus, 2 tablets are prescribed. 3 times / day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.
4. For recurrent genital warts, adults are prescribed 2 tablets. 3 times / day, children - 1/2 tab. 5 kg / body weight / day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then with a three-fold repetition of the indicated course at intervals of 1 month.

Side effects

The instructions for Isoprinosine indicate that the drug can cause side effects from some body systems, namely:

1. Polyuria (urinary system);
2. Joint pain (musculoskeletal system);
3. Weakness, dizziness, headache, drowsiness or insomnia (central nervous system);
4. Increase in the content of uric acid in the blood plasma and exacerbation of gout (metabolism);
5. Nausea, pain in epigastric region, vomiting, temporary increase in liver transaminases and alkaline phosphatase(digestive system).

Also medicine May cause allergic and dermatological reactions.

Overdose

There are no reliable data in the literature on clinical cases overdose of isoprinosine.

The good tolerance of the drug suggests that a slight overdose will not have a fundamental effect on the patient's body, but it is better to refuse personal experiments.

If an excess of the daily dosage of Isoprinosine by more than 1.5 times is recorded, especially in a child, it is necessary to as soon as possible consult a doctor, call an ambulance.

special instructions

Before you start using Isoprinosine tablets, you should carefully read the instructions. There are a few specific guidelines to pay attention to, these include:

1. After taking Isoprinosine tablets for 2 weeks, it is advisable to conduct laboratory monitoring of the level of uric acid in the blood.
2. Medicines of the immunosuppressant group may reduce the effectiveness of Isoprinosine tablets when used together.
3. In the case of using the drug for more than 1 month, laboratory monitoring of indicators of the functional activity of the liver is necessary.
4. It is necessary to carry out additional monitoring of the level of uric acid in the blood when using Isoprinosine tablets together with drugs that increase its level.

The drug does not have a direct effect on the speed of psychomotor reactions and the ability to concentrate.

drug interaction

Against the background of treatment with Isoprinosine, taking xanthine oxidase inhibitors and uricosuric drugs increase the likelihood of an increase in uric acid concentration in the blood.

With the combined use of the drug with Zidovudine or Acyclovir, there is a noticeable increase in the therapeutic antiviral effect of the above drugs. At simultaneous reception with immunosuppressants, the effectiveness of Isoprinosine is reduced.

Pharmacokinetics. Isoprinosine is an antiviral agent with immunomodulatory properties. The drug normalizes deficiency or dysfunction cellular immunity, inducing the maturation and differentiation of T-lymphocytes and T1-helpers, potentiating the induction of a lymphoproliferative response in mitogenic or antigen-active cells. Isoprinosine modulates the cytotoxicity of T-lymphocytes and natural killers, the function of T8 suppressors and T4 helpers, and also increases the amount of immunoglobulin G and complement surface markers. Isoprinosine increases the synthesis of interleukin-1 (IL-1) and the synthesis of interleukin-2 (IL-2), regulates the expression of IL-2 receptors. Isoprinosine significantly increases the secretion of endogenous γ-interferon and reduces the production of interleukin-4 in the body. Isoprinosine enhances the action of neutrophilic granulocytes, chemotaxis and phagocytosis of monocytes and macrophages. Isoprinosine inhibits viral synthesis by incorporating inosine-orotic acid into the polyribosomes of a virus-affected cell and inhibiting the attachment of adenylic acid to viral mRNA.
Pharmacokinetics. After oral administration at a dose of 1.5 g, the maximum concentration of inosine pranobex in blood plasma is reached after 1 hour and is 600 μg / ml. In the body, inosine pranobex is metabolized in the liver to form uric acid. The half-life of 4-(acetylamino)benzoate is 50 minutes, 1-(dimethylamino)-2-propanol is 3.5 hours. Excreted by the kidneys as metabolites.

Indications for the use of the drug Isoprinosine

• viral infections caused by a virus herpes simplex 1 and 2 types, Varicella zoster(including chickenpox), measles, mumps, cytomegalovirus, Epstein-Barr virus, including in patients with immunodeficiency states;
• viral respiratory infections;
• human papillomavirus infections: genital warts, papilloma virus infection vulva, vagina and cervix (comprising complex therapy);
• acute viral encephalitis (as part of complex therapy);
• viral hepatitis (as part of complex therapy);
• subacute sclerosing panencephalitis (as part of complex therapy).

The use of the drug Isoprinosine

Assign inside; The daily dose depends on the condition of the patient.
Adults and children over 12 years of age: 50 mg/kg body weight (6-8 tablets) in 3-4 doses per day; for children - 50-100 mg / kg in 3-4 doses. The course of treatment is 5-10 days, the maximum daily dose is 4 g.
Children aged 1-12 years: 50 mg / kg body weight (1 tablet per 10 kg body weight for a child weighing 10-20 kg, with a body weight over 20 kg - an adult dose is prescribed) in 3-4 doses, maximum daily dose - 4 g. To facilitate swallowing, the tablet can be crushed.
For diseases caused by viruses Varicella zoster(including chicken pox), measles virus, mumps, acute viral hepatitis and acute respiratory viral diseases, the course of treatment is 5-14 days. After reducing the intensity of the symptoms of the disease, treatment is continued for 1-2 or more days, depending on the symptoms.
In diseases caused by cytomegalovirus, Epstein virus - Barr treatment continue for 1-2 weeks after the decrease in the intensity of symptoms and more, depending on the symptoms.
In cases of recurrence of the disease caused by the virus herpes simplex, appoint 6-8 tablets. in 3-4 doses per day. After reducing the intensity of symptoms, a maintenance dose of the drug is prescribed - 1-2 tablets. per day. The course of treatment is 5-14 days.
With chronic viral hepatitis, chronic respiratory diseases, in patients under stress, with immunodeficiency states, the drug is prescribed in a daily dose of 50 mg / kg of body weight in accordance with the following schemes:
asymptomatic diseases: take the appropriate dose for 30 days with a break of 60 days;
diseases with moderately pronounced symptoms: take for 60 days with a break of 30 days;
diseases with severe symptoms: for 90 days with a break of 30 days. The course of treatment should be repeated required amount times, while constant monitoring of the patient's condition and the reasons for continuing therapy should be carried out.
In subacute sclerosing panencephalitis, the daily dose is 100 mg / kg, the maximum is 4 g / day with long-term use. In particularly severe cases, the recommended daily dose may be increased.
For infections caused by the human papillomavirus, 3 g / day (2 tablets 3 times a day) is prescribed as an addition to local therapy or surgical intervention according to the following diagrams:

• for 14-28 days for low-risk patients, then a break until the end of the 2nd month to achieve the maximum level of virus eradication;
• 5 days per week consecutively for 1-2 weeks per month for high-risk patients for 3 months.

The following conditions are considered high-risk in patients with recurrent or cervical dysplasia:

• papillomavirus infection of the genital organs, which lasts more than 2 years or 3 or more relapses in history;
• immunodeficiency resulting from a recurrent or chronic disease, or diseases that are sexually transmitted;
• chemotherapy;
• chronic alcoholism;
• poorly controlled diabetes;
• allergic diseases;
• prolonged use oral contraceptives(2 years or more);
• the level of folate in erythrocytes is less than 660 nmol / l;
• frequent change sexual partners;
• anal sex;
• age 20-25 years;
• smoking.

Contraindications to the use of the drug Isoprinosine

Hypersensitivity to the components of the drug, gout, hyperuricemia.

Side effects of Isoprinosine

Rarely - hyperuricemia.
From the gastrointestinal tract: dyspeptic phenomena (vomiting, nausea, diarrhea, constipation); very rarely - increased activity of hepatic transaminases.
From the side of the central nervous system: headache, dizziness, fatigue, nervousness, sleep disturbance.
Dermatological reactions: skin rash, itching.
Exacerbation of gout.

Special instructions for the use of the drug Isoprinosine

During therapy with Isoprinosine, the level of uric acid in the blood serum may increase, especially in men and the elderly. Therefore, the drug should be used with extreme caution in patients with gout, hyperuricemia, urolithiasis, as well as in violation of kidney function. When using the drug for more than 3 months, it is advisable to monthly monitor the most important functional indicators liver and kidney (creatinine level, transaminase activity), serum uric acid level and conduct a blood test.
Children. The drug is used in children over the age of 1 year.
Use during pregnancy and lactation
It is not recommended to use the drug during pregnancy and lactation due to the lack of studies.
The ability to influence the reaction rate when driving vehicles or work with other mechanisms. Not known.

Isoprinosine drug interactions

Do not take the drug simultaneously with immunosuppressants. With caution, the drug should be prescribed in conjunction with xanthine oxidase inhibitors or agents that promote the excretion of uric acid, including diuretics. At simultaneous application with azidothymidine, nucleotide formation is increased, including an increase in its bioavailability and intracellular phosphorylation in human blood monocytes.

Isoprinosine overdose, symptoms and treatment

No data.

Storage conditions of the drug Isoprinosine

In a dry, dark place at room temperature (not higher than 25 ° C).

List of pharmacies where you can buy Isoprinosine:

• Saint Petersburg

At modern treatment many diseases with viral nature origin, doctors widely use Isoprinosine, synthesized in the late 70s of the last century. In Russia, the drug has been used for the treatment and prevention of viral infections for a little less than 20 years. In addition to antiviral activity, Isoprinosine has immunomodulatory properties, which greatly expands the scope of its use and makes analogues of the drug less effective in the treatment of severe viral illnesses. Instructions for required application contains all the necessary information about the composition of the drug, indications for use, dosage and possible side effects. The price of the drug in Russia varies from 500 to 1500 rubles.

Composition, mechanism of action and application

The drug Isoprinosine is available in a single dosage form - in tablets, in the package of the drug there may be 20, 30 or 50 pieces. The main active ingredient of Isoprinosine is synthetically obtained inosine pranobex - a substance of animal origin. The main function of inosine is to enhance biochemical reactions in the body, due to this, the drug has the following mechanism of action:

• Increases the activity of T-lymphocytes - the main cells of the immune system of any person.
• Enhances the production of interferon.
• Violates the chain of formation of the virus in the body, blocks the production of enzymes necessary to activate pathogens.

Isoprinosine, used by the course, increases the body's resistance to bacteria and pathogenic viruses, which increases resistance to infections. The drug is prescribed as part of complex therapy in identifying such ailments as:

• Influenza, frequent respiratory infections.
• HPV, manifested by genital warts, warts.
• Diseases caused by the herpes virus different types, including herpes zoster, herpetic keratitis, genital herpes, chicken pox.
• Cytomegalovirus infection.
• Measles.

In combination with interferon preparations and other antiviral drugs, the effectiveness of Isoprinosine increases many times. When choosing antiviral agents it is necessary to listen to the opinion of qualified doctors, since only correct selection treatment regimens will help to safely cope with the disease. In some diseases, Isoprinosine is contraindicated, and then analogs with the appropriate mechanism of action are selected. Maximum concentration taken dose the drug in the blood is reached in two hours, the bioavailability of the drug is 90%. The accumulation of the active substance in the body is excluded, after absorption medicinal base Isoprinosine is excreted from the body no longer than two days.

Isoprinosine is highly effective drug against the human papillomavirus, which can be contracted through sexual contact and at home. The treatment regimen for identified HPV is selected based on the strain of the virus, the general state of immunity, and the severity of the infection. HPV, as well as the herpes virus, with any treatment regimens, will never be completely removed from the body. At modern level Pharmacology has yet to recognize this fact. The drug Isoprinosine can reduce the severity clinical manifestations HPV, herpes, prolongs periods of remission, helps in the elimination of warts and genital warts.

Viral respiratory diseases in people with high immunity occur without severe symptoms and without complications. Indications for the use of Isoprinosine in the treatment of acute respiratory viral infections, tonsillitis, tonsillitis, rhinitis are conditions in which one's own immunity cannot fully cope with the disease. Isoprinosine increases resistance defensive forces, especially the drug is necessary when choosing a treatment regimen for frequently ill children.

The effectiveness of the use of Isoprinosine in the treatment of chicken pox has been proven. Chickenpox in young children is usually mild, and all signs of the disease disappear in a few days. In older children with weakened immune systems, chickenpox causes fever, symptoms of intoxication. Instructions for use of Isoprinosine indicate that the appointment of a drug for chickenpox reduces the duration of the disease, prevents fever, improves general state, reduces skin rashes and itching.

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Dosage and course of treatment with Isoprinosine

The course of treatment with the drug and the recommended dosage are calculated based on the type of virus. In acute respiratory diseases, Isoprinosine is prescribed in a daily dosage of 50 mg per kilogram of body weight. This is approximately 8 tablets per day for adults. Isoprinosine is prescribed to children from the age of three, daily dosage is half whole tablet for every 5 kg of total weight. The resulting value is divided into three or four doses. The duration of taking the drug continues until the disappearance of clinical symptoms respiratory infections and two more days to fully consolidate the result. In recurrent forms of viral diseases, repeated courses up to 10 days after the use of the medicine, the interval between doses should be more than 8 days. With herpes infection in children and adults, Isoprinosine is used up to 10 days a day. acute period and within a month after the disease, 1-2 tablets for the prevention of relapses.

HPV can cause not only the appearance of warts on the mucous membranes of the genital organs, but also warts. Single formations pass on their own in a few months and do not cause much concern. But some HPV people causes the appearance of multiple papillomas and warts, which requires the use of highly effective therapy. Isoprinosine, when HPV is detected as part of complex therapy, reduces viral activity, increases the functioning of the immune system, this effect of the drug allows minimum terms get rid of skin lesions. Adults at HPV Isoprinosine appoint two tablets up to three times a day, therapy lasts up to a month.

Shown usage antiviral therapy during the use of surgical or other removal of papillomas and warts. Isoprinosine tablets with this therapy suppress the activity of the virus and do not allow new growths to appear on the skin and mucous membranes. With dysplasia on the cervix and when HPV is detected, the drug is prescribed for several courses at intervals of two weeks.

Instructions for use of the drug should not be a guide to the uncontrolled use of the drug. The desired effect of Isoprinosine will appear only in cases of its correct appointment which the doctor can provide after a comprehensive examination of the patient. Antiviral drug with HPV, herpes, warts will bring undoubted benefits during the entire course of therapy. There are also contraindications in which Isoprinosine is not used, when they are identified, analogues are selected.

Isoprinosine for children and adults is an antiviral drug with an immunomodulatory effect. The drug is needed to eliminate violations immune status with viral infectious diseases (ARVI, influenza, herpes, warts, papillomas, cytomegalovirus infection, measles, molluscum contagiosum).

To date, the drug is available in the form of tablets (it has no other forms of release). The active ingredient of the drug is inosine pranobex (500 mg). The release of Isoprinosine is carried out in only form and with only possible dosage active substance, so there are no varieties of the drug for adults and children. excipients are: magnesium stearate, wheat starch, povidone, mannitol.

Therapeutic action

The drug after application is able to give two main therapeutic effect 6 immunostimulating and antiviral. Antiviral effect is summed up due to two components - inhibition of the processes of reproduction of viruses and assistance in the functioning of the immune system, which due to this more actively eliminates viral elements and affected cells.

Stimulation of immunity by the drug is carried out due to the activation of the production of interleukins 1 and 2, interferon gamma, which have anti-inflammatory activity. In addition, after taking the drug, the production of interleukins 4 and 10 decreases, which support and enhance inflammatory processes in different systems human body. Due to such modulation of the formation of interferon and interleukins, the activity of the flow begins to decrease. inflammatory process in tissues, due to which there is a decrease in the lesion and restoration of the previous cellular structure.

Indications for use

Isoprinosine can be used to treat children and adults with impaired and normal immune system. The drug can be used in the treatment of the following viral pathologies:

Instructions for use

The instruction says that the medicine tablets must be taken by children inside after meals. Tablets should not be crushed, chewed, crushed in any other way. It is best to drink plenty of clean water.

The dosage of the drug should not change in the treatment of various viral pathologies. But it changes when used by children and adults.

• At the age of 3 to 11 years, the dosage of Isoprinosine must be calculated strictly individually, taking into account the weight of the child. The recommended ratio is 1 tablet for every 10 kg of weight (this is daily rate). For example, if a child weighs 20 kg, then he can be given two tablets in 1 day. The daily amount of the drug should be divided into 3-4 doses.
• At the age of 12 years, the dosage should also be calculated in accordance with the weight of the patient. Features of admission to children are the same - the result (for example, 5 tablets) should be divided into 3-4 doses during the day.

If the infectious process in the body of a child over 12 years old is quite difficult, then the recommended dosage should be increased by 1.5-2 times.

In the case of children aged 3 to 11 years, regardless of their condition, the dosage should not exceed the recommended values.

The duration of treatment with this drug will depend on the type of infectious disease, its stages, course, specifics of development in children's body. Therefore, the decision on the duration of treatment should be made by a qualified doctor.

Treatment of acute forms of SARS, influenza, measles

If a child is diagnosed acute form SARS, influenza, measles, infectious mononucleosis, molluscum contagiosum, then the duration of the drug should be 1-2 weeks at the recommended dosages.

Therapy should continue until the main clinical symptoms pathology, as well as two more days after all signs of the disease have disappeared.

If the infection caused the development of any residual effects, or in the presence of a severe and protracted course of the disease, the course of taking Isoprinosine is usually increased by necessary period. Extending treatment time with this drug must be agreed with the attending physician.

special instructions

The instruction says that during the entire time of taking Isoprinosine, it is necessary to take a weekly test for the concentration of uric acid in the blood and urine. In cases where the duration of treatment was no more than 2 weeks, an appropriate analysis is required upon its completion.

If the drug is taken for a long time, but every 4 weeks it is required to monitor cellular composition peripheral blood by calculating the leuco formula through general analysis blood, as well as monitor the work of the kidneys and liver.

If Isoprinosine is given to a child along with medications, which provide negative impact on the work of the kidneys and contribute to the accumulation of uric acid, then you need to take a weekly blood test for the concentration of uric acid.

It is not recommended to give children both immunosuppressants and Isoprinosine, since the simultaneous use of drugs of these groups will reduce the effectiveness of the drug. It is also not recommended to take drugs that are part of the xanthine oxidase group, because they will increase the level of uric acid in the blood, and can also lead to the development of gout (only when taken simultaneously with Isoprinosine).

The instruction of Isoprinosine indicates that the drug can be given to children only from the age of three. And also in cases where the baby's body weight exceeds 15 kg. In most cases, this medicine is prescribed for treatment in childhood, if ARVI, measles, influenza, molluscum contagiosum, infectious mononucleosis, chickenpox are diagnosed in young patients.

The duration of taking the drug should not exceed 5-15 days, but much will depend on the doctor's recommendation, the degree of development of the disease, the severity of the course, the stage of the disease and other factors. Therefore, the final decision on the duration of the course of admission should be made by a specialist.

Isoprinosine should be given to babies until all symptoms of the disease disappear. And also within 2-3 days after the elimination of all the main symptoms, so that therapeutic effect entrenched.

If this drug is used to treat a chronic infectious disease that has the ability to recur, then the drug should be taken within 1-2 weeks after stopping acute stage pathology. In addition, it is also recommended to continue taking the medicine (1 tablet each) for a month after stopping infectious process. This is done as a preventive measure.

Possible side effects and contraindications

Isoprinosine is a potent drug, so its use can lead to the development of various side effects. The most common of them are:

If any side effects occur, you should immediately stop taking the drug, and also consult a doctor for the selection of suitable analogues.

The use of the drug for the treatment of children is prohibited in the presence of individual intolerance and development allergic reactions different type to the drug substance. In addition, it is forbidden to use Isoprinosine for the treatment of children who have previously been diagnosed with the following diseases: gout, urolithiasis disease, renal failure, arrhythmia.

As noted above, this drug can only be prescribed by the attending physician. He must also determine the exact dosage, duration of the therapeutic course and other features of the use of the drug.