The drug for stimulating ovulation with clostilbegit. Possible side effects

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In most cases, ovulation stimulation with Clostilbegit is prescribed before IVF. To make the procedure more effective, it is combined with the use of Proginova, and also done hCG injection. These medicines are effective, but you can take them only as directed by your doctor. Be sure a woman undergoes a series of tests to exclude obstruction fallopian tubes(this can lead to an ectopic pregnancy).

What kind of drug and its effectiveness?

Clostilbegit is a pill for women aimed at stimulating ovulation. Sometimes prescribed to treat men when they have oligospermia. The composition of the drug includes clomiphene citrate, which inhibits the formation of estrogens. Due to this, the drug belongs to the group of antiestrogens. At the same time, Clostilbegit promotes the production FSH hormones and LH, which are required for ovulation to occur. The substance is rapidly absorbed into the blood, but is excreted from the body for a long time - the half-life is approximately 5-7 days.

The medicine is considered quite effective, but it should be taken with caution. It must be borne in mind that with its effectiveness, the tool is quite dangerous. With uncontrolled intake of pills, the ovaries can increase in size up to 5-8 cm, which is very dangerous for a woman. This condition may be accompanied by severe intoxication, drowsiness, pain in the lower abdomen.

In addition, by taking the drug, the chances of multiple pregnancy. That is, a woman can give birth to twins or even triplets. This is due to the fact that several eggs mature in the follicles at once, which, under appropriate conditions, can all enter the uterine cavity together.

Indications for use

Clostilbegit when stimulating ovulation is indicated in such situations:

Chiari-Frommel syndrome. In this case, the patient has amenorrhea, and the external genital organs also atrophy. There may be a slight discharge from the nipples. Due to this pathology, natural process ovulation.
Polycystic ovaries. Manifested by the absence of ovulation, increased production sex hormones (androgens and estrogens).
amenorrhea syndrome. In this case, the woman's menstruation disappears, ovulation becomes unstable or disappears altogether. This condition may be caused by taking some oral contraceptives therefore, before starting treatment with Clostibelgit, you should stop using any hormonal drugs.

Before prescribing the drug, a woman must undergo a series of examinations. The doctor must make sure that her temporary infertility is connected precisely with the anovulatory cycle. After all, the inability to become a mother may be due to other reasons. For example, this may contribute various tumors in area reproductive system. And taking Clostibelgit increases the rate of division cancer cells, so the malignant process spreads faster.

Contraindications and side effects

Not all patients can stimulate ovulation with Clostilbegit. The fact is that taking the drug has a large number of contraindications. In particular, it is not recommended to drink pills if a woman has:

Individual intolerance to any substance that is part of the drug (clomiphene or auxiliary components).
Liver diseases. The half-life of the drug from the body is long, so the drug has Negative influence on the liver. And in the presence of any pathologies this body, they can become even more pronounced
Ovarian cyst. With regular use of Klostilbegit, its growth may occur, and this is fraught with rupture of the neoplasm.
Oncological process in the body.
Poor eyesight. Taking the drug can lead to even more severe loss vision.
Risk uterine bleeding. If a woman has previously had bleeding from the uterus, she is contraindicated in taking the medicine. Otherwise, serious blood loss is possible (one of the side effects).

In the absence of contraindications, the medicine should be taken strictly according to the doctor's prescription. After taking Clostilbegit, you need to monitor your condition. If any side effects occur, the use of the medicine should be discontinued and consult your doctor. This condition usually occurs in patients who are prescribed high doses drug.

May cause headaches, nausea, depression, severe pain in the lower abdomen, sweating. At long-term use the drug can cause a sharp increase in weight.

In addition, the ovaries may increase in size. Therefore, you should regularly undergo ultrasound. With a slight increase in the ovaries, the medication must be urgently stopped.

IN rare cases appears skin dermatitis, itching in the nipples. Sometimes women complain of problematic urination accompanied by pain.

Instructions for use

How to properly stimulate ovulation? To do this, you must follow all the recommendations of the attending physician. In addition, one should study general instruction drug. If a woman has her menstruation (with some pathologies they are absent), it is necessary to start taking the medicine on the 5th day of the cycle. Take the drug on an empty stomach in a dose of 50 mg. The duration of treatment is 5 days, subject to constant monitoring of the ovaries by ultrasound.

What day does ovulation occur? This usually happens on the 11-15th day of the cycle, depending on the characteristics. female body. To find out the approximate day of your ovulation, you need from the first day last menstrual period count 14 days. That is, in most cases, it falls in the middle of the cycle. Also, to determine ovulation, you can use a special test that is sold at any pharmacy.

Sometimes Clostilbegit does not help the first time, so you need to repeat the course of treatment next month, taking the medicine from the 5th to the 10th day of the cycle, but with an increased dosage of 2 times. In the absence of ovulation, you can again undergo treatment for the third time, but without increasing the dose.

If the effect of therapy has not been obtained, it is necessary to take a three-month break, and only then repeat the course of therapy. For treatment male infertility the drug is prescribed once a day for 6 weeks in a row.

The combination of Klostilbegit, an injection of hCG and Proginov

Proginova is a drug containing the hormone estrogen. After a course of treatment with Klostilbegit, the woman's ovaries are depleted, so Proginova can be prescribed to restore the hormonal background. The scheme of stimulation of ovulation with Klostilbegit and Proginov is as follows:

On the 5th day of the cycle, a woman is prescribed Clostilbegit, which lasts up to 10-11 days. The dose of the drug is up to 100 mg per day, usually the drug is taken at a time, on an empty stomach in the morning.
The doctor constantly monitors the condition of the follicles with the help of ultrasound. When they reach 20-25 mm, they prepare for the onset of ovulation, they give an injection of hCG. Typically, ovulation occurs 40-45 hours after the injection. The injection contributes to the rupture of the follicle and the release of the egg, as well as the formation corpus luteum. This is usually accompanied by minor pain in the lumbar region. But to get reliable results required additional walkthrough ultrasound.
If ovulation has occurred, the woman is prescribed Proginova. Sometimes the drug is prescribed in advance (starting from the 5th day of the cycle) to prevent ovarian exhaustion.

Ovulation does not last long - up to 48 hours. Therefore, immediately after a woman has been given an hCG injection, she needs to have unprotected sex with a sexual partner. Moreover, the more times during these 48 hours they have sex, the higher the likelihood of conception. But after ovulation is over, it will be much more difficult to get pregnant.

You can buy Clostilbegit at any pharmacy. The cost of packaging is about 500 rubles for 10 tablets. The medicine is sold without a doctor's prescription, but self-medication is not recommended. This can lead to hormonal disruptions, ovarian enlargement and other serious consequences.

Thus, ovulation after Clostilbegit occurs quite quickly. However, the treatment is not effective in all cases. If after 6 months of therapy there is no effect, the doctor should review the treatment regimen and prescribe a new drug.

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Stimulation of ovulation with Klostilbegit is the most common technique used for treatment female infertility. In women, the components of Klostilbegit stimulate the production of hormones responsible for the maturation of follicles. The effectiveness of the drug is estimated at 30-40%, subject to the correct dosage and treatment regimen.

Who is prescribed ovulation stimulation

Stimulation of ovulation with Clostilbegit is prescribed to women with diagnoses of unknown origin . Before starting stimulation, the couple is sent for an examination to make sure that the real reason infertility is ovarian dysfunction.

Prescribe stimulants for male factor infertility, tubal obstruction, infectious and inflammatory diseases it just doesn't make sense. Clostilbegit (clomiphene citrate) anti-estrogen, effective medicine, but has many side effects, the most severe of which are hyperstimulation, ovarian exhaustion and, as a result, early menopause.

How to take Clostilbegit

Stage 1:

Taking pills to stimulate ovulation starts from day 2-5 of the cycle with a dosage of 50 mg / 1 tablet per day for 5 days.

From the 7-10th day of the cycle, the growth of the endometrium and follicles is monitored using ultrasound sensors. After one of the follicles reaches a size of 22-25 mm, an injection of hCG preparations is prescribed. (Horagon, Ovitrel, Pregnil). As a rule, ovulation occurs 24-27 hours after the injection.

When stimulated with Clostilbegit, the day of ovulation is the most auspicious time for conception. In IVF protocols, egg puncture is carried out before the onset of ovulation.

Stage 2:

The doctor prescribes medicines containing progesterone: Utrozhestan, Duphaston or progesterone injections. The duration of such support is 14 days, starting from the day of ovulation. Two weeks later, they take a blood test for hCG.

Stage 3:

Taking Clostilbegit inhibits the growth of the endometrium, which makes it difficult for a fertilized egg to implant. That is why, throughout the entire treatment, the thickness of the endometrium is controlled and estrogens are prescribed to drink. (Proginova).

What to do if there is no result

You passed the test on the 14th day, and it turned out to be negative? The pregnancy did not occur. Do not despair. If you ovulated but didn’t get pregnant, you will be offered to repeat the stimulation and, possibly, new drugs will be selected.

If the ovarian response was insufficient, then with repeated stimulation with Clostilbegit, the doctor will suggest adjusting the dosage of the drug. Most importantly, remember that taking stimulant drugs only affects the maturation of the follicles, and in no case does it treat hormonal disorders.

Side effects after taking ovulation inducing drugs

If the doctor confirmed that the follicles do not mature, this means that you have health problems and, most likely, not only in reproductive sphere. You should not expect that taking medication will solve all your problems.

Even the most modern facilities to stimulate ovulation have a side effect. Most often, patients after stimulation face such complications as:

the formation of cysts and polyps;
depletion of the ovaries and, as a result, early menopause;
hyperstimulation;
ovarian rupture;
hormonal disbalance;
problems with the digestive and nervous systems.

Clostilbegit stimulates ovulation quite effectively, but has many side effects. Talk to your doctor about ovulation stimulation and try alternative wellness treatments before starting Clostilbegyt. It is not recommended to use it for more than 6 cycles.

Stimulation of ovulation with Klostilbegit - reviews

According to the reviews of people who have encountered this modern medical technique, stimulation of ovulation is a fairly progressive method. Ovulation is a hormone-dependent process, so it is stimulated with drugs containing hormones.

Despite the fact that the action of all drugs is aimed at restoring the hormonal background of the body, there are different reviews about treatment: from those who became pregnant after ovulation stimulation with Klostilbegit and from those who did not help.

Elena:

After 2 years of unsuccessful attempts to get pregnant, she went to the doctor. An ultrasound was diagnosed as anovulation. I went through 2 courses of 4 months of ovulation stimulation with clostilbegit. Of the side effects - 4 large cysts grew. I managed to get pregnant a month after the end of the medication.

Masha:

I took ovulation medication for one cycle. Before that, my periods were irregular. I started taking Klostilbegit and a miracle - I got pregnant in the first cycle. They did an ultrasound, which showed three excellent eggs, only one was fertilized. Now my princess is 4.5 months old! Don't read bad reviews, everyone is different!

Questions and answers about Clostilbegit stimulation

There are many questions and reviews on thematic sites regarding the safety, expediency and effectiveness of the use of medicines.

Lisa:

Question: How is ovulation stimulation done with Clostilbegit? I heard negative reviews, they write a lot about early menopause. Need an answer from those who took the drug?

Olga:

Answer: Hello! I must say right away that Clostilbegit did not help me, 3 cycles stimulated. We started with the minimum dosage from the 2nd day of the cycle, then increased it. What's next, I don't know yet. The gynecologist directs to IVF.

Of the side effects - recovered greatly, especially in the thighs. I heard about early menopause, I don’t think that the ovaries will be depleted in 3 cycles.

Tatiana:

Question: How was the pregnancy after ovulation stimulation? Interested in reviews on the timing of hormonal support.

Alina:

Answer: And what is so special about pregnancy after Klostilbegit? I left like everyone else, without any complications. Toxicosis and tone on early term- a common occurrence. Support was up to 15 weeks, but now many pregnant women are prescribed Utrozhestan or Dufaston with tone. Read positive reviews and don't beat yourself up.

Alfiya:

Question: Is it possible to do stimulation with a bad spermogram from a husband? Passed before the start of treatment, diagnosed Asthenozoospermia. The clinic said that it's okay, the mobility is 53%, but I'm worried. I look forward to the responses and feedback from those who have experienced this.

Marina:

Answer: The doctor is right, everything is treated! It's good that they passed the tests before the start of stimulation. We have done the opposite.

I was stimulated for 4 months, the eggs matured in each cycle, and pregnancy did not occur ... I was very worried ... Then they advised me good doctor, and I went to him for a consultation, and so, he was very surprised that they did not check her husband. The husband nevertheless passed the tests, and he was also given low mobility due to inflammation. Treated for a month, then rested before stimulation.

In general, the 5th stimulation turned out to be victorious. 4 eggs matured, only one was fertilized. Now I'm at 12 weeks! I am writing this review to let you know there is hope! So don't be discouraged!

Elena:

Question: The gynecologist has appointed or nominated stimulation of an ovulation, I doubt. The fact is that according to ultrasound, I have my own ovulation, albeit not in every cycle. I'm afraid I'm hurting myself by taking ovulation medication. Tell me, who had a similar situation and Klostilbegit helped to get pregnant? Need feedback and advice on how to speed up ovulation with other, less harmful means?

Svetlana:

Answer: Slightly off topic, but still. Yes, Klostilbegit is not the easiest and safe drug but I wouldn't refuse. If you doubt the doctor's prescriptions, try to go for a consultation with another specialist. In any case, taking Clostilbegit in minimum doses and under the supervision of a physician is unable to harm the body.

I have polycystic ovaries, I was ovulating, but, apparently, the quality of the eggs was not important. It was treated for a long time, stimulated by Klostilbegit - it did not help. Now I am preparing for AI and stimulation with other drugs. From alternative ways treatment - only herbs, but after reading the reviews, I would not take them on my own.

Elena:

Question: Girls, SOS! The reproductive specialist prescribed ovulation stimulation with Klostilbegit 2 tablets a day, and today I found out that I missed 1 day of admission !!! What to do? Now nothing will work?

Valeria:

Answer: Do not worry, continue taking the tablets according to the scheme and extend it by 1 day. I also forgot to drink - the doctor said to do just that.

Stimulation of ovulation with other drugs

Gonal, Menopur, Puregon, Horagon, Dufaston, Utrozhestan and Proginova are drugs that stimulate ovulation in women and prepare the endometrium for implantation of a fertilized egg. The schemes of such stimulation are more complex and similar to those used by reproductologists in IVF protocols. There are both positive and negative reviews.

Reviews

Alexandra:

Question: I was diagnosed with primary infertility 3 years ago. She was treated for polycystic ovaries, endometritis. Ovulation was irregular. The clinic prescribed stimulation. I read the stories of everyone who got pregnant after ovulation stimulation, reviews, tips and tuned in to win ...

Now there are four stimulations with Clostilbegit behind me. No effect. How to stimulate ovulation yet? And, most importantly, what?

Anna:

Answer: helped me stimulation scheme with Gonal. Got pregnant right away. I started stimulation from the 2-6th day of the cycle and a dosage of 50 mg, from the 9th day I increased the dose to 75 units, from the 14th to 112. The injections continued until the 15th day of the cycle, and long-awaited ovulation was on the 18th day.

Christina:

Answer: Gonal and ovulation stimulation with an hCG injection also helped me. Pregnancy came from the second time. Clostilbegit was stimulated 6 times - it did not help.

Lena:

Question: Finally got my hands on the results of histology - no endometriosis!!! They wrote that polycystic ovaries are bad?

After laparoscopy, she took antibiotics, did physiotherapy. In the next cycle, I begin stimulation with Clostibegit, an injection of hCG, Utrozhestan and Metipred. I read a lot about ovulation stimulation with Klostilbegit negative feedback, so I’m wondering if it’s better to start right away with Gonal?

Julia:

Answer: I am one of those who got pregnant after ovulation induction. I am against taking Klostilbegit, the remedy is heavy, and it does not always help. He didn’t help me, and even spoiled the endometrium. Insist on Gonal stimulation - modern drug from him follicles grow by leaps and bounds.

Alexandra:

Answer: My friend is just one of those who were helped to get pregnant by ovulation stimulation with Gonal. She was also diagnosed with polycystic ovaries, but then the reproductive specialist explained that she had multifollicular ovaries, and this is often confused.

Everything worked out the first time! Before that, there were unsuccessful stimulation schemes with Klostilbegit and 2-year visits to clinics.

Pauline:

Question: Very upset - follicles do not grow! I am stimulated on the 6th day, starting from the 7th day of the cycle. Of these, 5 days - Puregon 100 units, today - 150 units. According to the ultrasound, the doctor added Menopur 75 units. Only 6 follicles have grown in size 5-6-10mm!!! It is not enough? What ovulation medications have you been prescribed? How many follicles have grown?

Kira:

Answer: Stimulated by Gonal. At 10 DC, 10 follicles of 10 mm approximately matured. I ovulated on DC 12 (30 day cycle). So everything is fine, don't worry!

Olesya:

Answer: Everything is fine! It's just too early. It was stimulated by Puregon, the dosage, however, was higher. 7 excellent follicles have grown! The main thing here is not quantity, but quality.

Alyona:

Question: She took ovulation induction medications. Scheme - Clostilbegit, Menopur with Proginova and Dufaston. The result was zero, only health problems remained ... I came to the appointment after stimulation on the 3rd day of the cycle, they sent me for an ultrasound scan and a new diagnosis: due to taking the drugs, a 7 cm cyst had grown!!! Girls who faced? How long to treat? I tuned in to IVF, but now, probably, they won’t let me in?

Sveta:

Answer: I sympathize, I myself grew a dermoid cyst after ovulation was stimulated. I had to remove it along with the ovary. The doctor said that the reason was not in the drugs, they just accelerated the process.

Ksenia:

Answer: Don't worry, there are different types of cysts. Go to the gynecologist - he will figure it out and prescribe treatment. I have resolved myself. I took only vitamins, a month somewhere. By the way, the cause was never found, they said hormonal failure.

Galina:

Question: Started stimulation. From the 3rd dts I stab Gonal-F. The doctor prescribed a dosage of 75 IU for 6 days. Has ovulation stimulation helped anyone get pregnant? Need feedback from those who have taken Gonal?

Sveta:

Answer: Hello! I took Gonal. After the second IVF attempt, I got pregnant. Twins were born - two boys! After stimulating ovulation with this drug, according to reviews, twins are often born.

My advice is not so much what is stimulated as the clinic and the doctor. So look for a good doctor.

Irina:

Answer: But it didn’t help me ... As a result, a cyst. Now I am healing. In general, the drug is very good, according to reviews, everyone praises.

Stimulation of ovulation with folk remedies

Traditional medicine is replete with recipes and tips on how to speed up ovulation and pregnancy. The reviews of people who were helped to get pregnant by ovulation stimulation with folk remedies, and the reviews of those who were disappointed in herbal treatment correlate in a 50/50 ratio.

Underestimate folk medicine it is not worth it, just as it is not worth relying entirely on it. In any case, it is necessary to consult with experienced herbalist so as not to harm your body.

According to reviews, the most popular folk remedies to stimulate ovulation decoction of sage containing a large amount of phytoestrogen. No less famous drugs from aloe petals mixed with milk and, a decoction of plantain seed and rose petals .

Quite often, the reason for the inability to conceive a baby in women is the lack of ovulation. In this situation, medicine can offer such an auxiliary reproductive method as ovulation stimulation or induction.

The most common drug for these purposes is Clostilbegit. In this article we will talk about how the follicle is stimulated with this medicine, how it works and what results it gives.

What it is

Stimulation of ovulation is a complex drug effect that takes place in several stages. On initial stage a woman immediately after menstruation is prescribed drugs that stimulate the growth of follicles in the ovaries. As soon as one of them, which is called dominant, matures and reaches a size of at least 17-18 mm, the woman is given drugs that stimulate the rapid maturation of the egg and its release from the follicle.

At the final stage, drugs containing progesterone or its analogues are prescribed to maintain pregnancy if the long-awaited conception has taken place.

Each of these steps is important. The stimulation itself takes place under the supervision of a doctor experienced in the treatment of infertility. First phase menstrual cycle when a woman is prescribed to take follicle-stimulating drugs, it should proceed under the supervision of an ultrasound scan. This will allow you to control the size of the follicle, choose the most right time For artificial stimulation ovulation, as well as help to avoid negative consequences, for example, the development of ovarian hyperstimulation syndrome.

"Klostilbegit" is a drug used in the first phase of the cycle, the task of which promote the maturation of a healthy and full-fledged egg in the follicle. It is considered one of the most commonly used, it is prescribed as a first-line drug in the treatment of functional infertility in women.

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Indications

The doctor will offer to stimulate ovulation for women who have been living a full sexual life for at least a year without the use of contraceptives, and pregnancy does not occur.

For women over 35 years old, a period of six months is considered a critical threshold. Important condition- a man should not experience problems with fertility. The spermogram must show its full male viability and the ability to fertilize the egg, otherwise the stimulation will not bring results.

The method is proposed as a treatment option for female infertility caused by ovarian dysfunction, polycystic disease, hypothalamic-pituitary insufficiency. Often this method helps women who are too thin or too full to get pregnant, who have endocrine disorders spontaneous conception is not possible.

Stimulation with "Klostilbegit" is carried out by women preparing for IVF or intrauterine insemination.

Contraindications

Stimulation is contraindicated in women with obstruction of the fallopian tubes. Pregnancy in this case may occur, but it will be ectopic and cause serious complications for the health and morale of a woman who dreams of a child.

Also, stimulation is not done in inflammatory diseases of the pelvic organs. First, they try to treat these ailments, relieve the symptoms of pathology, and improve the condition of the endometrium.

Stimulation is undesirable if a woman has problems with the health of the thyroid gland.

About the drug

If the examination is left behind, and the doctor decides to stimulate the ovulatory process with a drug such as Clostilbegit, we can talk about the beginning of the stimulation protocol.

The remedy itself is a non-steroidal antiestrogen drug. In moderate doses, it is able to stimulate the production of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin in the body.

Main active substance- clomiphene citrate. The drug is produced in the form of tablets with a dosage of 50 mg. In pharmacies, it is sold by prescription, self-medication with Klostilbegit is unacceptable.

Treatment regimen

It should be noted that there is no universal dose for all women and even for most of them. This drug is prescribed exclusively individually, depending on the height, weight of the woman, the characteristics of her reproductive processes.

In some women, the follicle can theoretically mature on its own, but the release of the egg does not occur, in others, even the formation of follicles on the ovaries does not happen. Therefore, schemes and dosages are chosen only by a doctor.

If a woman has a regular menstrual cycle, then most often the drug is prescribed from the fifth day of the menstrual cycle. If a woman has the first phase of the cycle lasts less than 14 days, the drug can be recommended from the third day.

There are two schemes:

The first involves taking 50 mg of the drug per day (1 tablet) for five days - from the 5th to the 9th day of the menstrual cycle (it should be counted from the first day of menstruation in this cycle). If ovulation does not occur on the 13-15th day, the second scheme is used in the next cycle.
According to the second scheme, the drug also starts on the 5th day and lasts for five days, but its dosage increases to 100 mg. The dose may vary: it will depend on how the woman's ovaries will respond to medicinal effect. Since the task is not only to cause full-fledged ovulation, but also to prevent hyperstimulation, in which multifollicular ovaries develop, there is a risk of cysts and other severe complications. Ultrasound monitoring of the behavior of the ovaries and follicles should be carried out daily.

If the second stimulation did not bring results, and there is no ovulation, the third course is carried out according to scheme No. 2. If there is no result, a three-month break is taken and the treatment is repeated.

The break is necessary in order not to cause exhaustion and premature aging ovaries. In total, stimulation with the drug can be carried out no more than two times (three months, and after a break for another three months).

If pregnancy does not occur, the drug is considered ineffective for this woman, and other methods are recommended for her - IVF, insemination, fertilization donor egg(if your own does not ripen)

After five days of admission, the size of the dominant follicle is estimated, and if it exceeds 17 mm, a drug is injected that stimulates the rupture of the follicle and the release of the egg, that is, ovulation itself.

When stimulated with "Klostilbegit", as in a similar process with the use of other follicle-stimulating medicines, an injection of hCG is given ( chorionic gonadotropin) at a dosage of 5,000 to 10,000 IU.

Ovulation occurs 24-36 hours after the injection. The doctor gives detailed instructions on the days that are considered the best for productive sexual intercourse.

From the 10-12th day of the cycle, drugs such as "Proginova", "Dufaston". They are needed to prepare the endometrium for implantation if conception has taken place.

If the test for 16-17 days after ovulation is negative, a blood test for hCG does not show the presence developing pregnancy, stop taking the funds and wait for menstruation.

Side effects

Women who underwent stimulation with "Klostilbegit" complain of pronounced side effects drug. These include:

nausea and a feeling of heaviness in the stomach;
increased flatulence, diarrhea;
headaches and bouts of severe dizziness;
violation of appetite in the direction of its increase;
drowsiness and lethargy;
inhibition of mental and physical reactions;

visual disturbances (double vision, fear of bright light, lacrimation);
more frequent urges to urination;
dryness in the vagina;
swelling and soreness in the chest;
hair loss;
allergy.

In addition, women often complain that the lower abdomen hurts, they are not in the mood, they have sensations of “flushing” of blood to the face, causing fever and sweating. Therefore, taking "Klostilbegit" is not recommended to drive a car and perform high-precision work or take actions associated with a risk to life that require heightened attention and clear vision.

most frequent women's issue relative to this medicinal product Does it affect weight? The answer is unequivocal - it does, many women note that, against the background of stimulation with Clostilbegot, they began to noticeably recover.

Who should not take the drug?

Instructions for use indicate that the drug should not be taken by women suffering from diseases of the kidneys, liver, with tumors in the pituitary gland, severe violations visual function, endometriosis and tumors of the reproductive system.

Efficiency and efficiency

The result can exceed the expectations of the family by half, since the stimulation of ovulation with Clostilbegyt increases the risk of having twins by about 15%.

According to the results of clinical data obtained over the past few years, the use of this drug for the treatment of anovulatory infertility in women, the probability of pregnancy in one course reaches 15%, almost 70% of women were able to become pregnant as a result of six courses of administration.

In preparation for stimulation ovulatory cycle the woman is undergoing a detailed examination. Sometimes the reception of "Klostilbegit" does not begin, because inflammatory and some hormonal problems, which lead to ovarian dysfunction, can be solved even at the preparatory stage, providing the woman with the necessary therapy.

Often there are enough recommendations on weight regulation: having lost only 5% of the initial weight, a woman significantly increases her chances of becoming a mother, her ovulation is restored naturally. Similar recommendations apply to women with insufficient body weight - weight correction and its increase to optimal indicator happens to be very effective.

Many are familiar with the excitement and feelings associated with unsuccessful attempts to get pregnant. Doctors recommend to calm down and relax, not to perceive unsuccessful attempts as a great personal tragedy.

If stress and “fixation” on the problem do not follow a woman on her heels, she will better side will change hormonal background, and ovulation will most likely be restored.

In any case, many women got pregnant that way - when they were already desperate, when they were no longer expecting and were not nervous because of the inability to conceive.

Release form

Produced Clostilbegit drug in the form of tablets of 50 mg. The tablets are round, flat shape, grayish-white color, no smell. The product is contained in dark-colored bottles, closed with a plastic cap.

pharmachologic effect

Active substance clomiphene belongs to the group of antiestrogens, which can stimulate the process ovulation . This is due to the activation of the synthesis of sex hormones (FSH, prolactin, LH), after specific binding in the ovaries and with estrogen hormones. If the body contains a small amount , there is a moderate estrogenic effect. If the body has high content estrogens, an antiestrogenic effect is noted.

Accordingly, when taking funds in not large doses there is an increase in the secretion of gonadotropic hormones and stimulation of ovulation. When taking large doses of the drug, the secretion of gonadotropins is inhibited. Thus, the effectiveness of ovulation stimulation depends on the dosage of the drug.

At the same time, the drug Klostilbegit does not show gestagenic and androgenic activity.

Pharmacokinetics and pharmacodynamics

Absorption of the active ingredient from the gastrointestinal tract occurs completely and very quickly. Metabolism occurs in the liver, it is also excreted by the liver, with bile. The half-life of the drug from the body is approximately one week.

Indications for use

Stimulation of ovulation Clostilbegit is carried out in the case of syndromes in which a woman has a lack of ovulation:

Stein-Leventhal syndrome ;
Chiari-Frommel syndrome ;
galactorrhea syndrome (provided that it is not provoked by the presence of a tumor in the body);
syndrome (among other things, and the one that is associated with the use of oral contraceptives).

Contraindications

Do not use the drug in such cases:

intolerance to the active ingredient or any other substance present in Clostilbegit;
pregnancy ;
uterine bleeding in history;
serious liver disease;
(to prevent the risk of its rupture);
visual impairment;
oncological processes;
function downgrade .

Side effects of Clostilbegit

Side effects Clostilbegita may occur if the drug is prescribed to the patient in large doses. Most often, the following side effects are possible:

nausea, vomiting, abdominal pain;
asthenia;
, And ;
, high level anxiety ;
increased appetite, tides , weight gain.

Sometimes, in rare cases, the patient's ovaries may increase (sometimes up to 5-8 cm.) It is important in the process of taking the medicine to constantly monitor the size of the ovaries by ultrasound, as well as regularly measure basal temperature.

In very rare cases, there may be chest pain, dermatitis with itching, urination disorders.

When taking the drug increases the possibility of developing multiple pregnancy (Klostilbegit and twins are a likely occurrence.) It also increases the likelihood of , ectopic pregnancy.

In addition to the side effects described above, vaginal dryness, dysmenorrhea, breast compaction, and allergic reactions may occur.

Instructions for Klostilbegit (Method and dosage)

Instructions for use involves the use of tablets inside. In this case, the dosage and regimen of administration depends on the diagnosis and prescription of the attending physician.

If the patient has , then the period of taking the tablets depends on how pronounced the reaction to the drug from the ovaries is. Women who have monthly cycle regular, should start taking pills from the fifth day of the menstrual cycle. Women with amenorrhea can start treatment with the drug on any day.

There are several schemes by which you can take this tool.

First scheme provides for taking 50 mg of the drug for five days, and at the same time it is necessary to control the reaction of the patient's ovaries by conducting constant laboratory and clinical researches. As a rule, ovulation occurs between the eleventh and fifteenth day of the cycle. If this scheme does not help to get the desired result, then you should see how to take these pills according to the second scheme.

Second scheme reception provides that the tablets are taken from the fifth day of the cycle, 1000 mg daily. In the absence of ovulation, the same scheme is practiced again.

If unsuccessful, after taking the remedy, they take a break for three months, after which the course of treatment is repeated. Those who become pregnant then stop taking the drug. If the second course of administration was ineffective, then the treatment will also be ineffective.

It should be fate that during each course the total dose of the drug should not exceed 750 mg.

When treating a patient with you need to start taking the drug with 50 mg per day, as there is a tendency to hyperstimulation.

If the patient does not have periods due to prolonged use of contraceptives, it is necessary to start taking tablets with 50 mg per day, while a five-day treatment is usually effective already at the first attempt.

For men, tablets are prescribed 50 mg once or twice a day, treatment lasts for six weeks. It is important to constantly monitor the spermogram.

Overdose

In case of an overdose of the drug, the patient may experience the following symptoms:

vomiting, nausea, pain in the epigastrium;
enlargement of the ovaries.

Does not exist specific treatment in case of overdose, as there is no antidote. In case of an overdose, symptomatic treatment practiced removing the drug from the body.

Interaction

There is no interaction of Clostilbegit with other drugs. It is rational to take pills with gonadotropic hormones.

Terms of sale

You can buy it in pharmacies with a prescription.

Storage conditions

Store at a temperature not exceeding 25 degrees in a dry place.

Best before date

Clostilbegit can be stored for 5 years.

special instructions

Before starting treatment with the drug, it is important to pass full examination, including examination by a gynecologist, determination of hormonal status, etc.

In the process of taking pills, it is important to carefully monitor the size of the ovaries, liver function. It is advisable to prescribe treatment with a normal or reduced content of gonadotropin in the urine, with normal condition ovaries, as well as normal function adrenal and thyroid gland

This remedy should be taken only under the supervision of a gynecologist, who determines whether it is necessary to increase or decrease the dose.

If ovulation stimulation has been successful, the patient may be prescribed .

Since a short-term visual impairment is possible during the treatment, drivers should not drive vehicles at this time.