Mexidol is a mild treatment for severe neurological disorders. Mexidol: side effects, reviews, description, consequences of taking

Good drug

Grade: 5

I often drink, so I take this drug to make the waste easier. I noticed that during the reception, the brains are slow to think (stupidly you sit like in a evkurka and stare at TV or at one point) and you constantly want to eat. These are my personal comments. Without a doubt, the drug increases endurance up to 30%. These are my personal observations, you may not have this.

Useless

Grade: 3

As far as the injections of "Mexidol", which were pricked last year, helped me, the pills, the course of which I drank quite recently, turned out to be useless. I take the drug to suppress the symptoms of vegetative-vascular dystonia as one of the medicines that are recommended by the doctor. So, after a ten-day course of droppers with Mexidol, a persistent remission always set in, excruciating headaches and dizziness, internal tremors and chills stopped. Anxiety and feeling of lack of air left. And then for six months, at least, she did not need special maintenance therapy. But with the pills somehow did not work out. Although she took them exactly according to the instructions: first, one three times a day, then two with the same regularity, and reduced the course to nothing, returning to taking three things a day. So the package lasted me just a month. But this month I didn’t get the result that I got in a week from injections. Some of the symptoms are gone, in particular headaches, tinnitus, insomnia and increased fatigue. But from the side of the psyche, everything remained in the same place. And panic attacks, which caused an acute shortage of air, and irritability, and breakdowns.

Anxiety does not heal

Grade: 3

Mexidol treated cervical osteochondrosis. Tablets come in 125 ml. Pack of 50 pieces (inside 4 blisters). The cost is high for me. They are easy to drink, small in size, swallowed quickly. The instructions are huge, it took a lot of time to study them.
I was prescribed a small dosage, 1 tablet twice a day. It was necessary to drink for three weeks, without increasing the number of tablets.
At first, there were no sensations at all - neither improvement nor deterioration. Then I felt that my head stopped hurting badly. The state of anxiety tormented me constantly, the drug did not fight at all with nervous tension. I had to take additional drugs for irritability and fatigue. And these are additional costs.
Dreams were only bad, or not dreamed at all. In the mornings I felt dejected and useless. It seemed that I did not rest at all, I wanted to go back to sleep, close myself from everyone, turn off the phone and not leave the house.
The pills coped with dizziness, everything went away for me, but they can’t cope with nervousness. Either immediately take some Magnicum in addition, or look for a stronger drug.

With a sharp change in weather, the drug does not help

Grade: 4

Mexidol was given to me intramuscularly. Terrible headaches began to subside only after 5 injections. Dizziness passed, there was clarity in thoughts.
The injection is very painful, it is done in the buttock. Then this place burns, the leg goes numb and is taken away. After the injection, I lay down on the couch for 20-30 minutes, and only then could I do some business.
Before the injection, you need to eat tightly, but I did not know this. At the next procedure, everything went dark in my eyes and I lost consciousness. It's okay, but unpleasant memories remain. Then I always had a good dinner before the injection. When the drug was injected into a vein, my throat always began to tickle, a nasty taste of the medicine appeared in my mouth and I just had a cough. I had a cough with every injection!
After the course, I recovered normally, returned to my normal lifestyle. Everything seemed to be fine, but a month later the dizziness started again. I had to switch to Mexidol tablets.
Now I drink them on an ongoing basis, 1 tablet three times a day. The condition is stable, there is no depression, there is an interest in life. With a sharp change in the weather, deterioration appears, not very critical, but unpleasant. We have to walk in a foggy state until the weather improves.

A gentle option for neurosis

Grade: 5

This is not an antidepressant, the medicine simply improves cerebral circulation, but how does it help! About a year ago, against the background of problems with work and family, I developed a serious neurosis, and then a psychotherapist in the district clinic prescribed Mexidol. This is a very gentle option, because the drug does not dull your emotions, does not put you in a state of blissful calm, like antidepressants, it eases the physical condition, has a beneficial effect on the brain, which in turn leads to an improvement in the mental state. I felt it well for myself. The medicine is of an average price category, it costs around five hundred rubles for fifty tablets. You need to take it three times a day. I didn’t notice any side effects, I can even get behind the wheel, there is no lethargy, drowsiness. The medicine acts quickly, in a few days. The sensations were such, as if I was gradually getting out of the water - every day I get out of the problems that tormented me. I began to sleep better, anxiety, obsessive thoughts, tearfulness disappeared. Life sparkled with colors, interest in the world around us again woke up. Improved relationship with her husband. I drank the medicine for a month, the treatment has already ended, but I feel good, the symptoms of neurosis do not return. In such a simple way, it was possible to cure the nerves.

There was distraction from the pills

Grade: 4

I bought Mexidol in tablets. There are 50 pieces in a box. The method of application was strictly according to the instructions. I started treatment with 2 tablets twice a day, then the dosage reached 6 tablets. This limit cannot be exceeded. At the end of the course, the dosage was decreasing. The whole course took me two and a half weeks. For each, this period is individual, and can last from 2 to 6 weeks.
In the very first days after taking the drug, I began to feel a slight feeling of intoxication, as from alcohol. It seems to be good, the brain is saturated with oxygen, but it is not comfortable to be in this state all day long, I became distracted and inattentive. It bothered me a lot at work.
Then I just got drowsy. Sleep is the best medicine for the body, but I just slept on the go. It was hard to wake up in the morning and didn't look very good.
Of the pluses, I will highlight that the state of the VVD did not worsen and I became calmer and more resilient. Problematic situations did not cause violent emotions in me, my nerves were not naughty, but at the same time, the state was closer to apathy than to happiness. Maybe the drug helped someone as intended, it only kept my nerves at rest, and did not let me worry over trifles.

Reasonable application required

Grade: 4

I came across the drug Mexidol about a year ago, the first thing that surprised me was that it is sold mainly only in Russia, moreover, we have it on the list of vital drugs, although there is little information about it, clinical trials were carried out very superficially and judge their reliability is quite difficult. Immediately the thought creeps in that someone needs it. One reassures that the drug is quite affordable, in some diseases, especially those associated with mental disorders, it shows its effectiveness.
But I still distrust drugs with such a wide spectrum of action, they are usually prescribed without necessity or when the doctor cannot make a real diagnosis, and the drug really improves the general condition of the patient by increasing mood, reducing anxiety and normalizing brain function, but the real problem often remains and resurfaces after the drug is discontinued, and new problems may also join, due to the body's addiction. Therefore, treatment with Mexidol often needs to be carried out in combination with consultations of a psychologist or psychiatrist, especially if there is such an "interesting" diagnosis as VVD.

Helps with exacerbations

Grade: 4

Periodically tormented by headaches, malaise and increased nervous excitability, especially in the autumn or spring seasons. From which "Mexidol" helps well. I take it, on the recommendation of the attending physician, twice a year, during attacks of exacerbation of the consequences of an old injury (it all started after the accident). I start taking one tablet three times a day, I bring it up to the maximum daily dose of six tablets, then there is a gradual decrease in dosage.
From the first days there comes some relief: spasmodic pains disappear, as if a pressure hoop is removed from the head, the mood rises. No bouts of blues and depression. I don’t observe any special side effects from it: neither lethargy, nor vice versa, nervousness. Even meteorological sensitivity decreases, I practically cease to react to weather changes. Only now I noticed such a strange thing - every time I go through a course of treatment with Mexidol, my biological rhythm shifts. Like a baby who confuses day with night: far after midnight on a viper, and during the day I fall asleep on the go. Such a "schedule" greatly complicates the workflow, you have to drink a shock dose of coffee in the morning.

Handled the task

Grade: 5

The drug was prescribed by a doctor after a small concussion of the brain. She refused intravenous administration, did not want to, so she took it in tablet form. It was frankly annoying that while taking the drug, some products are prohibited - those that contribute to the production of dopamine. Otherwise, you can "earn" excessive contraction of the cells of the cerebral cortex and, as a result, convulsions and even coma. Okay, alcohol is a taboo, it can be painlessly endured. But it was hard to refuse cheese and chocolates. And especially from your favorite bananas and strawberries. It's the most strawberry season here, and I can't eat a single berry. The mood, of course, on this occasion is nasty.
But, in principle, "Mexidol" coped with the task. And not bad. I had to drink for quite a long time, more than a month and a half, strictly observing the recommended dosage: increasing from the beginning of the intake and decreasing towards its completion. After the course of administration, semi-consciousness, attacks of weakness, disorientation in space and sharp headaches disappeared. And also the nervous system stabilized, the blues and depressive states left. In the morning after sleep, I no longer felt weak and unwilling to leave the bed.

In 1996, a good composition of an antioxidant orientation appeared in Russian pharmacies - the drug "Mexidol". The composition has found wide application in neurology for its ability to normalize metabolic processes in brain tissues and protect them from the harmful effects of free radicals. But its use is not limited to this. It is prescribed under appropriate conditions by narcologists, surgeons and psychiatrists. Specialists highly appreciate the new generation drug for its unique properties and pharmacological advantages over other neuropsychotropic compounds:

Increase resilience to stressful situations.
Restore speech functions, improve memory properties after brain damage as a result of ischemic attacks and strokes.
Prevent seizures.
Neutralize various kinds of intoxication of the body.

The composition of the drug

Instructions for use says that the active substance in Mexidol is 3-hydroxy-6-methyl-2-ethylpyridine succinate. Succinates are salts of succinic acid, a natural metabolite for humans, a participant in energy metabolism reactions. Tissues in sufficient quantities receive acid with rye bread and, with good nutrition, do not experience a lack of it.

Dosage forms of Mexidol:

pills;
solutions for injections (50 mg AI/ml).

The drug is produced with a mass fraction of active ingredient of 5%. The volume of ampoules is 2 ml/5 ml. One contour package includes 5 ampoules.

2 times more, that is, 10 ampoules (2 boxes of 5 ampoules with a volume of 2 ml) each contains Mexidol 10, respectively. The drug is administered according to a certain scheme, depending on the pathology.

There may also be preparations containing 5-10 ampoules with a solution of the same concentration (5%) and a volume of 2 ml / 5 ml.

One tablet contains:

DV - 125 mg;
sodium carmellose;
lactose;
magnesium salt of stearic acid.

Mechanism of action

Cells are bounded by a plasma membrane consisting of a lipid bilayer. The active substance from the composition of the drug in question slows down or prevents peroxidation of membrane phospholipids. Hence its membrane-protective properties. As an antioxidant, DV inhibits oxidative processes involving free radicals, after which the antioxidant enzyme is activated, and the fluidity of biological membranes increases.

This, in turn, leads to an improvement in the transport of neurotransmitters, an increase in the rate of binding of receptor complexes with membrane-binding enzymes. As a result, the body better resists oxygen deficiency and all the processes provoked by hypoxia.

Indications for use

The use of Mexidol showed that he:

increases the level of dopamine in brain cells;
normalizes cerebral blood supply and metabolism in the nervous tissue;
reduces platelet aggregation;
reduces the concentration of cholesterol in the blood;
reduces the manifestation of signs of intoxication of the body;
activates the aerobic stage of glycolysis;
increases the number of ATP and creatine phosphate molecules;
activates cellular respiration in mitochondria and energy production;
stabilizes biological membranes;
normalizes metabolism in the myocardium after ischemic attacks;
reduces necrotic phenomena in the myocardium;
improves the properties of the heart: contractility and conductivity;
improves visual acuity by improving the functionality of the retina.

Tablets "Mexidol" help to overcome the consequences of high emotional stress, which is expressed:

in the restoration of functions that provide training;
in peaceful sleep;
in the elimination of somatovegetative problems.

The drug Mexidol, administered intramuscularly, also helps to treat the consequences of alcohol intoxication:

restores human behavior;
eliminates withdrawal symptoms.

The answer to the question "What helps mexidol?" can be supplemented with its geroprotective action, expressed:

in the correction of memorization and learning, which are violated during aging;
in reducing the level of aging markers.

The drug enhances the effect of antidepressant, tranquilizing drugs, thereby reducing their side effects and reducing therapeutic dosages.

Pharmakinetics

The peak concentration of DV in the blood occurs half an hour after intramuscular injection. After this period, the active substance quickly penetrates into the tissues, from where it is also quickly excreted.

In the liver, DV is converted into other pharmacologically active metabolites. It is excreted in the urine, partly in its original form.

Mexidol in tablets is characterized by rapid absorption of the active substance, its distribution throughout the tissues and the same rapid release. After 4-5 hours, laboratory tests no longer detect DV in the blood.

Why are Mexidol injections prescribed? Mexidol in ampoules is indicated for:

body poisoning;
withdrawal intoxication and its accompanying disorders;
primary open-angle glaucoma as part of complex treatment;
acute myocardial infarction as part of complex therapy;
anxiety states;
cognitive disorders due to atherosclerosis;
vegetovascular dystonia (VVD);
slowly progressing cerebrovascular insufficiency;
traumatic brain injury;
acute violation of cerebral blood supply.

For Mexidol tablets, the indications are similar:

asthenic syndrome;
intoxication after taking antipsychotic drugs;
alcohol withdrawal;
ischemia of the heart;
anxiety as a consequence of neurotic conditions;
encephalopathy of various nature;
skull trauma;
epilepsy.

There are few contraindications for taking Mexidol. It is not recommended for patients with acute renal or hepatic insufficiency, as well as individual sensitivity to DV and auxiliary components in the composition of the drug.

Pediatrics does not have statistically reliable data obtained in the study of the effect of the drug on the child's body. Therefore, only the attending physician prescribes Mexidol to children, and after administration, monitors the course of the disease. The composition is prescribed in case of a child with a traumatic brain injury, as well as for the treatment of purulent infections of the nervous tissue.

Toxicity and side effects

The instructions for use of the drug say that minor side effects, as well as low toxicity, are the undeniable advantages of the drug. Side effects of mexidol are rare and can be in the form of:

symptoms of an allergic reaction;
drowsiness;
excessive dryness of the oral mucosa;
nausea.

The person taking the drug may complain of individual reactions:

lethargy;
general weakness;
lack of appetite;
flatulence;
allergic conditions.

Taking the drug Mexidol (injections) may be accompanied by jumps in blood pressure, impaired coordination of movements, circadian rhythm "sleep-wakefulness", emotional reactivity. Taking the drug can be calm for the liver. Also kept in good order:

blood composition;
frequency of respiratory movements;
heart rate and electrocardiogram;
blood pressure parameters.

Stopping the medication is not accompanied by a withdrawal effect.

Instructions for the use of injections

With intravenous administration, Mexidol (ampoules) is diluted with saline. The composition is administered intramuscularly for a duration of 1.5 to 3 minutes. Drip - carried out at a speed of 80-120 drops / minute. The severity of the pathology affects the dosage and duration of the course. In case of impaired cerebral blood supply, when the patient is in a specialized department of neurology or intensive care, 400 mg (8 ml) of the drug is injected intravenously for 15 days twice a day. The daily dose cannot exceed 1600 mg.

For the next 15 days, the same dosage is observed, but it is already administered 1 time per day. In the future, Mexidol injections are administered intramuscularly for 10-15 days at a dosage of 200 mg (4 ml) of the drug. At the end of the course, the doctor recommends taking tablets: 0.25-0.5 g / day for 1-1.5 months, while the daily dose is divided into 2-3 doses.

About compatibility with other medicines

Mexidol may be prescribed to enhance the action of some compounds that have a psychotropic effect, such as:

tranquilizers;
analgesics;
anticonvulsants;
benzodiazepines;
carbamazepine and others.

In any therapeutic regimen, Mexidol shows compatibility with all components of complex treatment. Its advantages also include the ability to reduce the toxicity of ethanol. Its use in the treatment of alcohol dependence is based on how Mexidol and alcohol interact, as well as on the ability to remove ethyl alcohol metabolites from tissues.

Comparison with other drugs

Mexidol is a new generation drug, so it is compared with other already known formulations.

In a number of drugs similar in purpose, a special place is occupied by an analogue of Mexidol - Actovegin, which has the appropriate use and is prescribed together with mexildol to achieve the desired therapeutic result. For those who are interested in what is the difference between them or what is better Actovegin or Mexidol, you need to know that the use of Actovegin is often accompanied by an allergic reaction, since calf blood is the raw material for its production. Although with it, the affected tissues recover faster. The active substances in the composition of both drugs can interact, influence the structure of each other and increase the manifestation of side effects. Therefore, they are not mixed in one syringe.

Other analogues of Mexidol are also presented on the pharmaceutical market. For example, some cheap drug analogues differ only in additional components. It is impossible to use an analogue instead of a medicine such as Mexidol on its own. These questions are decided by the doctor on an individual basis for each. He also determines in each case which is better, for example, Mexiprim or Mexidol. Another thing is Mexicor and Mexidol, because the first is a generic or synonymous with the second. It also finds application as a means of improving the condition of patients after a stroke, relieving anxiety and fears, increasing attention, and eliminating the consequences of alcohol intoxication.

The use of the drug in veterinary medicine

Mexidol vet is an analogue of a well-known drug. It is intended for use in veterinary medicine, in particular in the treatment of cats and dogs, if they suffer from:

epilepsy;
heart failure in chronic or acute form;
disturbed cerebral blood supply;
brain injury.

Mexidol vet helps to prepare animals for surgery, and after surgical treatment ensures the recovery of four-legged patients. Mexidol vet also serves to prevent disorders observed in the aging of animals. It helps to prepare dogs for exhibitions, to endure extreme loads during training.

The medicine Mexidol vet can also be in the form of tablets or a solution intended for injection. Ampoules can have a volume of 1-2 ml. The active substance is the same as in the composition taken by people. The solution contains active ingredient at a concentration of 25-50 mg per 1 milliliter. It is administered intramuscularly. As part of No. 10, respectively, 10 ampoules of 1 ml of a solution with a mass fraction of active ingredient of 2.5% at a price of 320 rubles. For 200 rubles more expensive drug, in which 10 (5 ampoules of 2 ml) 5% solution. One tablet of the drug weighing 250 mg contains 50 mg of active ingredient.

The duration of the course, as well as the dosage, is determined by the veterinarian. The drug is contraindicated if the animal is individually sensitive to any component of Mexidol vet.

Toothpaste Mexidol Dent

Dentistry was also able to take advantage of the anti-inflammatory and antioxidant properties of the drug in the form of Mexidol Dent toothpaste. It showed its effectiveness in the form of:

increase immunity;
reduce bleeding gums;
effective remedy in the treatment of periodontitis.

Thanks to Mexidol Dent toothpaste in patients in the oral cavity:

micro-wounds heal faster;
mucosa is restored;
bacteria die.

The above effects are possible if Mexidol Dent is used 2-3 times a day.

For those who have hypersensitive gums, a variety of Mexidol Dent paste with potassium nitrate is provided to treat caries and reduce tooth sensitivity, which is usually observed with the loss of the main components from the mineral composition.

Toothpaste Mexidol dent can whiten teeth, be used to treat stomatitis and gingivitis. The manufacturer took care of comprehensive dental care and, in addition to Mexidol dent paste, released an elixir for rinsing and healing the oral mucosa. Mexidol toothpaste costs about 70 rubles. For comparison: for tablets (50 pcs.) Mexidol, the price starts from 400 rubles.

Patients, like doctors, leave positive feedback about the medication. Everyone notes from him: wide indications for use, minimal side effects, the ability to improve the condition of patients with vegetovascular dystonia, as well as those who have had microstrokes and other disorders of cerebral circulation.

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Mexidol is a synthetic antioxidant. It has a pharmacological effect at three levels at once: metabolic, vascular and neuronal.

Due to the directed action of the drug on all links of pathogenic free radical oxidation, it is successfully used to treat a variety of neuropsychiatric and cardiovascular diseases.

About the drug, composition, form of release

The drug is available in two forms - tablets and solution for injection. Mexidol tablets contain 125 mg of ethylmethylhydroxypyridine succinate. They are white, coated, available in packs of 30 or 50.

In addition to the active substance (Mexidolum), the preparation contains auxiliary components: potato starch, white clay, Tween-80, octadecanoic acid, calcium stearate (E-572), methylcellulose, talc and titanium dioxide. The liquid form of the drug is produced with a dosage of the medicinal substance of 50 mg / ml in ampoules of 2 or 5 ml.

The active ingredient of the drug is mexidol (chemical name ethylmethylhydroxypyridine succinate). This neuroprotector has the following pharmacological action:

inhibits free radical lipid oxidation (antioxidant action);
has a membrane-stabilizing effect (membrane-protective effect);
reduces the likelihood of cell damage during ischemia (antihypoxic effect);
has anticonvulsant activity;
has a nootropic and anxiolytic effect;
reduces the concentration of cholesterol and "bad" lipoproteins (lipid-lowering effect);
has an anti-stress effect.

Due to its chemical structure, mexidol helps to normalize the structural and functional elements of the cell membrane, restore the neurotransmitter balance, improve the energy balance of the cell, reduce the viscosity of the membranes and increase their fluidity.

Mexidol - what helps?

What helps Mexidol is easy to understand by pharmacological effects - the drug is prescribed both for the prevention and treatment of many conditions. Usually these are diseases associated with disorders in the functioning of the nervous or cardiovascular systems. Mexidol is prescribed in the following situations:

Prevention and treatment of circulatory disorders in the brain (chronic and acute);
Rehabilitation after head injuries;
Various encephalopathies;
Syndrome of vegetovascular dystonia;
neurosis and anxiety;
Complex therapy of atherosclerosis with cognitive disorders;
Complex therapy of coronary heart disease;
Poisoning with antipsychotic drugs;
Withdrawal syndrome;
Open-angle glaucoma;
Prevention of the occurrence of pathologies against the background of regular extreme loads;
Influence of stress factors.

Mexidol is used to treat diseases that are accompanied by neurodegeneration, such as stroke, and. It has an anti-amnesic effect and improves memory and thinking abilities, for which Mexidol is used in senile people and in patients with cognitive disorders.

The drug can be used in complex treatment with anticonvulsants, as it potentiates their action and reduces their dosage.

Considering what Mexidol helps with, it should be noted that the drug can also be used in healthy people with increased emotional, mental or physical stress, to save the body's resources.

Instructions for use Mexidol for various diseases

A solution of Mexidol is administered intramuscularly or intravenously, the dosage is selected depending on the pathology, the patient's conditions and his individual characteristics.

With intravenous drip infusions, the administration of the drug should be slow - no faster than 60 drops per minute, jet administration should last 5-7 minutes.

A single dose should not exceed 250 mg, and a daily dose should not exceed 800 mg.

Complex therapy with Mexidol injections for cerebrovascular accidents begins with the introduction of 200-400 mg intravenously every day, and from 5 days it changes to intramuscular injection of 100 mg three times a day. The duration of the course is 2 weeks.

Treatment after head injuries consists in intravenous administration of 200 - 500 mg of the drug daily 3 times for 15 days. Dyscirculatory encephalopathy is treated with Mexidol for about a month, the first half of the month is administered intravenously at 100 mg 3 times a day, and the second - intramuscularly 1 time per day.

In the treatment of cognitive disorders in the elderly, 100-300 mg of the drug is administered intramuscularly for two to four weeks.

According to the instructions for use, Mexidol in the form of tablets is taken 125-250 mg 2-3 times a day. The daily dose should not exceed 800 mg.

On average, therapy lasts 7-14 days, the dosage is gradually increased, and then gradually reduced towards the end of therapy. In the combined treatment of coronary heart disease, the drug is taken for 1.5-2 months.

special instructions

The drug may cause impaired concentration and drowsiness. Therefore, during therapy, you should refrain from driving vehicles and work that requires a quick response.

It is important to remember that Mexidol enhances the effect of some anticonvulsant and sedative drugs, so the doctor must adjust their dosage in order to avoid adverse events.

Side effects of Mexidol, contraindications

Taking Mexidol can cause side effects. The most common complaints are nausea and dry mouth, but other adverse effects may also occur:

drowsiness;
dizziness;
change in blood pressure;
allergic reactions;
sleep disorders;
increased sweating;
feeling of anxiety and emotional tension.

The drug should not be taken in case of insufficiency of the liver and kidneys, in childhood, pregnant and lactating women, as well as in the presence of hypersensitivity to the components of the drug. Overdose causes drowsiness and is treated with detoxification therapy.

Analogues Mexidol, list of drugs

Analogues of the Russian drug Mexidol are:

armadin,
Venokor,
Dinar,
Zamexen,
meximidol,
Mexiprim,
Nicomex,
Elfunat.

Remember that a doctor's consultation is required, but if you are going to use an analogue of the already prescribed Mexidol - instructions for use, price and reviews of analogues do not apply and cannot be used as a guide for treatment. When replacing Mexidol, consultation with the attending physician is required, it is possible to change the treatment regimen, dosages, etc.

According to doctors, Mexidol is a low-toxic drug that has a large therapeutic breadth and practically no side effects. It shows high efficiency in the treatment of neurological, mental and cardiovascular diseases. It can be used to treat chronic and acute processes, as well as to support the body during increased mental and physical stress.

The circulatory system serves as the highways of the body, providing its parts with nutrition and oxygen.

Ensuring a sufficient level of blood supply is critical for the normal functioning of internal organs, especially the brain.

It is known that in case of problems with blood circulation, brain dysfunction can occur, and even a very short period of oxygen starvation negatively affects this most important organ. A modern remedy, Mexidol, helps to solve this problem, moreover, effectively and safely.

Circulatory disorders can occur due to various diseases. The most common causes of such dysfunction are cardiovascular diseases - stroke, encephalopathy, atherosclerosis.

To date, effective drugs have been developed, the action of which makes it possible to prevent the lack of oxygen supply to the brain. But Mexidol raises or lowers blood pressure? How does the drug affect the body in general?

Mexidol is designed for use in neurology, surgery and even psychiatry. It is used for:

circulatory disorders, including cerebral;
vegetovascular dystonia;
brain dysfunctions in atherosclerosis;
withdrawal syndrome caused by alcoholism.

Mexidol is used as part of complex therapy. In addition, this remedy is applicable in the treatment of peritonitis, acute forms of pancreatitis, as well as the relief of the effects of an overdose of antipsychotics.

In all these cases, Mexidol showed a fairly high efficiency of use. It is also allowed and recommended to use the drug for the treatment and prevention of asthenic conditions, cardiac ischemia, cognitive disorders. The use of Mexidol is also indicated for persistent exposure to stress-forming factors and excessive psychological or physical stress.

This list is not complete - the drug is recommended for the treatment of a fairly wide profile of diseases and dysfunctions associated with insufficient blood supply to internal organs.

Mexidol injection solution

The industry produces this drug in two main forms - for oral use and for injection. Coated tablets weighing 125 mg are administered orally. For injections, capsules of a five percent solution of the active substance with a volume of two milliliters are produced. Pharmacology does not release other dosage forms of this drug.

Is it possible to drink Mexidol with high blood pressure? It is possible and sometimes it is necessary, but only as directed by a doctor. The fact is that there is no clear answer to the question of whether Mexidol increases or decreases. It mainly depends on the individual characteristics of the patient. Therefore, Mexidol at elevated pressure can bring both benefit and harm. T

Biochemistry of drug exposure

The biochemical action of Mexidol differs from the action of drugs of the neuropsychotropic group. Unlike the latter, which act on certain receptors, it inhibits free radical oxidation in the body.

Under the influence of the active substances of the drug, certain antioxidant enzymes are activated. Mexidol has a beneficial effect on the cell membrane, restoring its functionality, reduces the colloidality of the lipid layer, and increases the activity of mitochondria.

As a result, energy metabolism at the cell level improves, which leads to the restoration of the apparatus and structure of cell membranes. These positive changes, in turn, through complex biochemical processes, affect the stabilization of neural connections, significantly increasing the effectiveness of neurotransmitters - special substances that serve to transmit impulses coming from the body's nerve cells.

At the same time, antioxidant processes are enhanced, which has a beneficial effect on the functionality of cells and the organ as a whole. In addition, Mexidol reduces pressure and can bind free lipids. This effect of the drug leads to a significant anti-cholesterol effect from its use, which improves the quality of the blood vessels.

Due to the complex action, the drug actively affects the functioning of the brain, improving the relationship between its structures, restores blood circulation and helps to reduce the intensity of oxidative processes, which are the main cause of dysfunction at the cellular level.

This allows Mexidol to effectively influence the mechanism of occurrence and development of a wide range of diseases, suppressing them, and initiate the launch of protective biochemical reactions of the body itself.

At the same time, the drug is non-toxic, and its directed effect causes fewer side effects and unwanted reactions of the body than the action of neuroleptics.

Mexidol is also used as a prophylactic.

medicinal effects

The pharmacological effects of taking Mexidol are very diverse. It acts both at a deeper level, improving neural connections, and more generally, significantly improving the patency of the circulatory system. As a result, the effect of its use is very wide and pronounced in various pathologies.

Pressure tablets Mexidol

Mexidol protects the central nervous system, having a vegetotropic and antiparkonic effect. Removes neurotic deficit, has anti-alcohol and tranquilizing effect. Can Mexidol lower blood pressure?

Yes, taking the drug can improve cerebral circulation, increase the life of platelets, while reducing the level of blood density and reducing the risk of developing blood clots.

The overall level of bad cholesterol is also reduced. The action of Mexidol favorably affects the body's resistance to various external aggressive factors. Resistance to shock, situations, prolonged lack of sleep or violation of its cycles and regimen increases.

The body's resistance to ethanol and some other intoxicating substances, including drugs, increases.

In addition, the tool has a pronounced anti-stress effect. Its reception leads to the normalization of post-stress processes and reactions, the normalization of sleep.

It decreases on the cardiovascular system, reduces the risk of developing pathologies of the brain and myocardium, the occurrence of which is associated with psychological stress. The anticonvulsant effect of Mexidol manifests itself regardless of the pathogenesis of seizures.

The drug is effective for stopping chronic processes associated with excitation of epileptiform brain activity. At the same time, the remedy also helps with convulsions caused by external factors, such as the administration of certain drugs.

Receiving Mexidol improves memory functions, increases the ability to learn, reduces the intensity of processes that lead to forgetting previously acquired knowledge, skills and abilities.

Memory disorders and functions of the higher nervous system are also stopped, caused by various traumatic effects - electric shock, severe blows to the head, compression injuries of the brain, and the action of scopolamine, benzodeazipine and others.

The effect of post-alcohol amnesia and deterioration of the narrative functions of the human brain is also reduced.

Laboratory studies have revealed the ability of Mexidol to have a beneficial effect on internal organs experiencing insufficient blood supply. Mexidol is an active antihypoxant, its action is based on the activation of energy-synthesizing functions of cells.

A number of experiments, both on experimental animals and on isolated, perforated organs, showed the effect of the drug in hypobaric oxygen starvation, including that accompanied by an excess of carbon dioxide accumulated in the tissues of the organ.

According to this effect, Mexidol is significantly superior to such well-known drugs as piracetam and pyritinol.

These drugs are able to relatively effectively fight the lack of oxygen only at a very high dosage, and the supersaturation of cells with carbon dioxide reduces the effectiveness of their effects to almost zero.

In addition, side effects from overdoses of these drugs often do not allow them to be used effectively enough. In addition, the drug has a positive effect on human catabolism due to the presence of succinic acid salts in its composition. These substances act as catalysts for the tricarboxylic acid cycle, the most important chemical process at the cellular level.

A clearly calculated amount of this substance, which is a toxic agent in case of an overdose, is not capable of harming health, but can actively improve cellular respiration. Thus, this succinate enhances the beneficial effect of Mexidol.

A specialist can prescribe a drug for dysfunctions not related to the brain. Sometimes Mexidol is used at low pressure and, oddly enough, at high pressure too.

Side effects

Studies have revealed a low level of side effects of Mexidol, the practical absence of a negative effect on the state of the body in case of proper use.

An overdose of the drug threatens to cause disorders of the body's motor functions and general inhibition of motor skills. Coordination of movements may be disturbed, reflex muscle contraction will decrease.

Mexidol slightly increases blood pressure, causes drowsiness, and depression. Such side effects were recorded only in 2 - 3 percent of patients taking the drug, mainly among those undergoing treatment for alcohol dependence.

At the same time, even hyperdoses of Mexidol do not cause side effects characteristic of many other drugs. For example, no negative effect of the agent on liver function was noted. On the contrary, when the dose is exceeded, the drug begins to act on the body as a hepatoprotector, restoring the functionality of this organ.

There was no deterioration in memory, the appearance of drowsiness and disturbances in the functionality of the brain. The drug is not addictive.

The tool does not affect the temperature of the body, the work of the heart and kidneys.

There were no problems with respiratory function, vision, and other side effects, even during long-term use, over two to three months.

Any combination of Mexidol and other drugs should be taken after consultation with a specialist

Interaction and routes of administration of the drug

Mexidol interacts with most somatic drugs without causing any undesirable effects and without inhibiting their action.

The use of this drug enhances the therapeutic effect of taking antidepressants, anticonvulsants, drugs used to treat the brain in Parkinson's disease.

At the same time, Mexidol can reduce the toxic effects of the components of some drugs on the body. The drug is taken orally, in the form of tablets, 2-3 times a day. The maximum dose is 6 tablets per day.

Treatment lasts from 6 days to 6 weeks, the termination of treatment is carried out by a gradual decrease in the dosage used. The instructions for use accompanying the drug Mexidol do not indicate at what pressure its administration is indicated.

The injective form of Mexidol is administered by syringe or by drip.

In the first case, both intravenous and intramuscular administration are allowed, and these methods can be used in one course of treatment, combined with each other.

Jet and drip administration involves the use of sixteen milliliters of sodium chloride per 200 milligrams of the active substance.

It is undesirable to abruptly stop taking the drug. Only individual intolerance can become an indication for it.