What are the side effects of phenazepam. The drug "Phenazepam": overdose, side effects, as well as a number of other characteristics

Phenazepam (tablets) - a fresh description of the drug, you can see pharmachologic effect, side effects, Phenazepam (tablets). Useful reviews o Phenazepam (tablets) -

Anxiolytic (tranquilizer), benzodiazepine derivative.
Preparation: PHENAZEPAM®

The active substance of the drug: non appropriated
ATX encoding: N05BX
KFG: Tranquilizer (anxiolytic)
Registration number: Р №003672/01
Date of registration: 16.06.08
The owner of the reg. Award: VALENTA PHARMACEUTIKA OJSC (Russia)

1 tab.

500 mcg

Pills white color, flat-cylindrical, with a chamfer.

1 tab.
phenazepam (bromodihydrochlorophenylbenzodiazepine)
1 mg

Excipients: lactose, potato starch, collidone 25 (polyvidone), calcium stearate, talc.

10 pieces. - cellular contour packings (5) - packs of cardboard.

Tablets are white, ploskotsilindrichesky, with a facet.

1 tab.
phenazepam (bromodihydrochlorophenylbenzodiazepinone)
2.5 mg

Excipients: lactose, potato starch, collidone 25 (polyvidone), calcium stearate, talc.

50 pcs. - polymer cans (1) - packs of cardboard.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action Phenazepam (tablets)

Anxiolytic (tranquilizer), benzodiazepine derivative. It has a pronounced anxiolytic, hypnotic, sedative, as well as anticonvulsant and central muscle relaxant action.

It has a depressing effect on the central nervous system, which is realized mainly in the thalamus, hypothalamus and limbic system. Enhances the inhibitory effect of gamma-aminobutyric acid (GABA), which is one of the main mediators of pre- and postsynaptic inhibition of transmission nerve impulses in the CNS.

The mechanism of action of phenazepam is determined by stimulation of the benzodiazepine receptors of the supramolecular GABA-benzodiazepine-chlorionophore-receptor complex, leading to the activation of GABA receptors, which, in turn, causes a decrease in the excitability of the subcortical structures of the brain and inhibition of polysynaptic spinal reflexes.

Pharmacokinetics of the drug.

Suction

When taken orally, the drug is well absorbed from the gastrointestinal tract. Cmax of phenazepam in the blood - from 1 to 2 hours.

Metabolism

Metabolized in the liver.

breeding

T1 / 2 is from 6 to 18 hours. The drug is excreted mainly in the urine.

Indications for use:

Neurotic, neurosis-like, psychopathic, psychopathic and other conditions accompanied by anxiety, fear, increased irritability, tension, emotional lability;

Reactive psychoses;

Hypochondriacal-senestopathic syndrome (including resistant to the action of other tranquilizers);

Vegetative dysfunctions;

sleep disorders;

Prevention of states of fear and emotional tension;

Temporal and myoclonic epilepsy;

Hyperkinesis and tics;

Muscle stiffness;

Vegetative lability.

Dosage and method of application of the drug.

The drug should be taken orally. single dose Phenazepam is usually 0.5-1 mg.

Medium daily dose Phenazepam is 1.5 - 5 mg, it is divided into 2-3 doses: usually 0.5-1 mg in the morning and afternoon, at night - up to 2.5 mg. The maximum daily dose of Phenazepam is 10 mg.

For sleep disorders, the drug should be used at a dose of 0.25-0.5 mg 20-30 minutes before bedtime.

With neurotic, psychopathic, neurosis-like and psychopathic conditions, the initial dose of the drug is 0.5-1 mg 2-3 times / day. After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 4-6 mg / day.

With severe agitation, fear, anxiety, treatment begins with a dose of 3 mg / day, quickly increasing the dose until a therapeutic effect is obtained.

In epilepsy, the dose is 2-10 mg / day.

At alcohol withdrawal Phenazepam is prescribed at a dose of 2.5-5 mg / day.

In diseases with increased muscle tone the drug is prescribed 2-3 mg 1-2 times / day.

To avoid the development of drug dependence course treatment the duration of the use of Phenazepam is 2 weeks. In some cases, the duration of treatment can be increased up to 2 months. When canceling npenapat, the dose is reduced gradually.

Side effects of Phenazepam (tablets):

From the side of the central nervous system and peripheral nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, fatigue, dizziness, impaired concentration, ataxia, disorientation, slowing down of mental and motor reactions, confusion; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially when used in high doses), decreased mood, dystonic extrapyramidal reactions, asthenia, myasthenia gravis, dysarthria; very rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, strax, suicidal tendencies, muscle spasm, hallucinations, anxiety, sleep disturbance).

From the hemopoietic system: leukopenia, neutropenia, agranulocytosis, anemia, thrombocytopenia.

From the side digestive system: dry mouth or salivation, heartburn, nausea, vomiting, loss of appetite, constipation or diarrhea, impaired liver function, increased activity of hepatic transaminases and alkaline phosphatase, jaundice.

From the side reproductive system: decreased or increased libido, dysmenorrhea; effect on the fetus - teratogenicity (especially the first trimester), CNS depression, respiratory failure, suppression of the sucking reflex in newborns.

Allergic reactions: skin rash, itching.

Other: addictive drug addiction, lowering blood pressure; rarely - visual impairment (diplopia), weight loss, tachycardia; at sharp decline dose or discontinuation of use - withdrawal syndrome.

Contraindications to the drug:

myasthenia;

Angle-closure glaucoma ( acute attack or predisposition)

Severe COPD (may increase respiratory failure);

Acute respiratory failure;

Pregnancy (especially the first trimester);

The period of breastfeeding;

Children's and adolescence up to 18 years (safety and efficacy not determined);

Hypersensitivity to benzodiazepines.

With caution, the drug should be used in case of hepatic and / or renal failure, cerebral and spinal ataxia, hyperkinesis, a tendency to abuse psychotropic drugs, organic diseases brain (paradoxical reactions are possible), hypoproteinemia, depression, in elderly patients.

Use during pregnancy and lactation.

During pregnancy, Phenazepam is used only for health reasons. The drug has toxic effect on the fetus and increase the risk of developing birth defects when used in the first trimester of pregnancy. Application therapeutic doses in more late dates pregnancy can cause depression of the central nervous system of the newborn. Permanent application Phenazepam during pregnancy can cause withdrawal syndrome in the newborn.

The use of the drug immediately before childbirth or during childbirth can cause respiratory depression in the newborn, decreased muscle tone, hypotension, hypothermia, weakening of the act of sucking ("sluggish baby" syndrome).

Special instructions for the use of Phenazepam (tablets).

Special care is required when prescribing Phenazepam for severe depression, since the drug can be used to implement suicidal intentions.

It is necessary to use the drug with caution in elderly and debilitated patients.

in renal/liver failure and long-term treatment painting needs to be controlled peripheral blood and liver enzymes.

The frequency and nature of side effects depend on individual sensitivity, dose and duration of treatment. With a decrease in doses or discontinuation of the use of Phenazepam, side effects disappear.

Like other benzodiazepines, phenazepam has the ability to cause drug dependence when long-term use in high doses (> 4 mg / day).

With a sudden discontinuation of the drug, a withdrawal syndrome may occur (especially when using the drug for more than 8-12 weeks).

Phenazepam enhances the effect of alcohol, so the use of alcoholic beverages during treatment with the drug is not recommended.

Pediatric use

Children, especially younger age are very sensitive to the CNS depressant action of benzodiazepines.

Influence on the ability to drive vehicles and control mechanisms

Phenazepam is contraindicated for use by drivers of vehicles and other persons performing work that requires quick and accurate reactions.

Drug overdose:

Symptoms: with a moderate overdose - increased therapeutic action and side effects; with a significant overdose - a pronounced depression of consciousness, cardiac and respiratory activity.

Treatment: vital control important functions body, maintaining respiratory and cardiovascular activity, symptomatic therapy. As antagonists of the muscle relaxant action of Phenazepam, strychnine nitrate is recommended (injections of 1 ml of a 0.1% solution 2-3 times / day). As a specific antagonist, flumazenil (anexat) can be used: i.v. 0.2 mg (if necessary, the dose can be increased to 1 mg) in 5% glucose (dextrose) solution or 0.9% sodium chloride solution.

Interaction of Phenazepam (tablets) with other drugs.

At simultaneous application Phenazepam with other drugs that cause CNS depression (including hypnotics, anticonvulsants, neuroleptics), one should take into account the mutual enhancement of their action.

With the simultaneous use of Phenazepam with levodopa in patients with parkinsonism, the effectiveness of the latter is reduced.

With the simultaneous use of Phenazepam with zidovudine, the toxicity of the latter may increase.

With the simultaneous use of Phenazepam with inhibitors of microsomal oxidation, the risk of developing toxic effects Phenazepam.

With the simultaneous use of Phenazepam with inducers of microsomal liver enzymes, the effectiveness of Phenazepam decreases.

With the simultaneous use of Phenazepam with imipramine, the concentration of the latter in the blood serum increases.

With the simultaneous use of Phenazepam with antihypertensive drugs may increase the severity of antihypertensive action.

With the simultaneous use of Phenazepam with clozapine, respiratory depression may increase.

Conditions of sale in pharmacies.

The drug is dispensed by prescription.

Terms of storage conditions of the drug Phenazepam (tablets).

List B. The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C. Shelf life - 3 years.

Phenazepam is a drug of the benzodiazepine group. It suppresses the activity of the central nervous system, pointwise affecting such brain structures as the thalamus and hypothalamus, as well as the limbic system.

Together with gamma-aminobutyric acid(GABA) enhances pre- and postsynaptic inhibition of nerve impulse transmission. Activation of GABA receptors consists in the stimulation of the GABA-benzodiazepine-chlorionophore prescription complex of benzodiazepine receptors by phenazepam.

As a result, the sensitivity of GABA receptors to this mediator increases, thereby enhancing the inhibitory effect of GABA on the central nervous system. At the psychological level, the patient has a decrease in emotional stress, anxiety, anxiety, glimpses positive attitude, depression and obsessive fears go away.

The central muscle relaxant effect is due to the inhibition of polysynaptic spinal afferent inhibitory pathways (to a lesser extent, monosynaptic ones). Direct braking possible motor nerves and muscle function.

Phenazepam is a highly active tranquilizer that has anxiolytic, anticonvulsant, central muscle relaxant and sedative action. The tranquilizing and anti-anxiety effect is superior in strength to Phenazepam analogues. Also, the drug has anticonvulsant and hypnotic action. Practically no effect on affective, hallucinatory and acute delusional disorders.

When taken orally, the drug is well absorbed from the gastrointestinal tract. Cmax phenazepam in the blood - from 1 to 2 hours. It is metabolized in the liver. T1 / 2 is from 6 to 18 hours. The drug is excreted mainly in the urine.

Indications for use

What helps Phenazepam? The drug is prescribed for the following diseases or states:

• Psychopathic, psychopathic, neurosis-like, neurotic and other conditions that are accompanied by emotional lability, tension, increased irritability, fear, anxiety;
• Vegetative lability;
• Reactive psychoses;
• Muscle stiffness;
• Hypochondriacal-senestopathic syndrome;
• Tics and hyperkinesis;
• Vegetative dysfunctions;
• Myoclinic and temporal lobe epilepsy;
• sleep disorders;
• Prevention of emotional stress and fear.

Recommended as a means to overcome fear and emotional stress in extreme situations. With schizophrenia, high sensitivity to antipsychotic medications. It is used for resistance to various tranquilizers.

Instructions for use Phenazepam and dosage

Phenazepam injections in / m or / in (stream or drip): for the rapid relief of fear, anxiety, psychomotor agitation, as well as for vegetative paroxysms and psychotic conditions, the initial dose is 0.5-1 mg (0.5-1 ml of a 0.1% solution) , the average daily dose is 3-5 mg, in severe cases - up to 7-9 mg.

Inside: for sleep disorders - 0.25-0.5 mg 20-30 minutes before bedtime.

For the treatment of psychopathic, neurosis-like and psychopathic conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability, the dose of Phenazepam can be increased to 4-6 mg / day.

IN neurological practice in diseases with increased muscle tone, the drug is prescribed intramuscularly at 0.5 mg 1 or 2 times / day.

With severe agitation, fear, anxiety, treatment begins with a dose of 3 mg / day, quickly increasing the dose until a therapeutic effect is obtained.

In epilepsy, Phenazepam is administered by injection intramuscularly or intravenously, starting with a dose of 0.5 mg.

For the treatment of alcohol withdrawal - inside, 2-5 mg / day or / m, 0.5 mg 1-2 times a day, with vegetative paroxysms - / m, 0.5-1 mg.

The average daily dose is 1.5-5 mg, it is divided into 2-3 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. In neurological practice, in diseases with muscle hypertonicity, 2-3 mg are prescribed 1 or 2 times a day.

The maximum daily dose is 10 mg. In order to avoid the development of drug dependence during course treatment, the duration of Phenazepam is 2 weeks (in some cases, the duration of treatment can be increased to 2 months).

Phenazepam in the form of tablets is prescribed for oral administration, in stationary conditions daily dosage the drug is up to 4 mg, for therapy convulsive conditions with epilepsy, the dose is increased to 9 mg. At outpatient treatment up to 0.5 mg of the drug is prescribed once a day.

In order to relieve alcohol withdrawal, the patient is prescribed 5 mg of medication per day. For the treatment of sleep disorders - 1 mg half an hour before rest. The maximum daily dose should not exceed 10 mg.

With severe agitation, fear, anxiety, treatment begins with a dose of 3 mg / day, quickly increasing the dose until a therapeutic effect is obtained.

• When canceling, the dose is reduced gradually. During the course of treatment, the use of alcohol is prohibited!

Contraindications

The appointment of Phenazepam is contraindicated in the following cases:

• Coma;
• myasthenia;
• COPD (possibly increased respiratory failure);
• severe form of depression;
• Angle-closure glaucoma;
• Poisoning with analgesics or acute poisoning alcohol;
• Acute respiratory failure;
• I trimester of pregnancy;
• Children under 18;
• With lactation;
• Intolerance to benzodiazepines.

Be wary appoint when:

• Hepatic and/or kidney failure, cerebral and spinal ataxia, history of drug dependence;
• Tendency to abuse psychoactive drugs;
• Organic diseases of the brain, psychosis (paradoxical reactions are possible), hypoproteinemia;
• Sleep apnea (established or suspected);
• Elderly patients.

Side effects

At the beginning of treatment, especially in elderly patients, may develop:

• drowsiness, fatigue, dizziness, impaired concentration, ataxia, disorientation, slowing down of mental and motor reactions, confusion;
• rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially when used in high doses), decreased mood, dystonic extrapyramidal reactions, asthenia, myasthenia gravis, dysarthria;
• very rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, anxiety, sleep disturbance).

Other side effects:

• leukopenia, neutropenia, agranulocytosis;
• anemia, thrombocytopenia;
• dry mouth or drooling, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea;
• abnormal liver function, increased activity of hepatic transaminases and alkaline phosphatase, jaundice;
• urinary incontinence, urinary retention, impaired renal function;
• decreased or increased libido, dysmenorrhea;
• effect on the fetus - teratogenicity (especially the first trimester), CNS depression, respiratory failure, suppression of the sucking reflex in newborns whose mothers used the drug during pregnancy;
• skin rash, itching;
• addiction, drug dependence, lowering blood pressure;
• phlebitis or venous thrombosis(hyperemia, swelling or pain at the injection site).

Overdose

In case of an overdose of Phenazepam, it is possible to increase all side effects, as well as failure of breathing and heart rate.

The antidote is strychnine nitrate or flumazenil. Treatment is symptomatic.

Pregnancy and lactation

Phenazepam is contraindicated for use at any stage of pregnancy and during lactation.

drug interaction

• Simultaneous use with Levodopa preparations leads to a decrease therapeutic action the latter;
• Simultaneous use with Imipramine leads to an increase in the plasma concentration of the latter;
• Simultaneous use with Zidovudine leads to an increase in the toxicity of the latter;
• Simultaneous use with antiepileptic drugs, sleeping pills, drugs, preparations containing ethyl alcohol or alcoholic drinks, leads to a sharp increase in the therapeutic effect of the latter;
• With simultaneous use with Clozapine, there is an increase in side effects associated with respiratory depression.

Phenazepam analogues, list of drugs

If necessary, you can replace Phenazepam with similar preparations, list:

1. Tranquezipam
2. Fezipam
3. Phenazepam-Ros
4. Phenorelaxan
5. Elzepam

When choosing analogues, it is important to understand that the instructions for use of Phenazepam, price and reviews of drugs similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

The average price in pharmacies is 497-520 rubles.

Store in a place protected from light and out of the reach of children at a temperature not exceeding +25°C. Shelf life - 3 years.

Phenazepam, side effects, which will be discussed later, is a tranquilizer. It is used for the treatment of reactive-type psychoses, with syndromes that cannot be treated with other tranquilizers, neurotic and psychopathic conditions, with autonomic dysfunctions and sleep disorders. The drug can remove causeless fear and emotional tension. It is also used during epilepsy, with tics and hyperkinesis, during the development of rigidity of muscle structures, autonomic lability.

The medicine is used inside. It greatly affects performance various structures brain. In some patients, due to the action of the drug, headaches, migraines appear, a depressed state may occur, or, conversely, unreasonable excitement.

In case of an overdose of Phenazepam, the instructions for use describe the following symptoms:

1. If the dose was relatively moderate, then the patient's side effects increase or the therapeutic effect of Phenazepam increases.
2. With a large dose of an overdose, cardiac activity is inhibited, breathing problems arise, and a depressed state is recorded in a person.

When should this medication not be used?

Contraindications for the use of this medicinal product the following:

1. Coma or shock.
2. Myasthenia.
3. An acute attack of angle-closure glaucoma or a predisposition to this disease.
4. Severe illnesses respiratory system and lungs, which can cause respiratory failure.
5. Pregnancy and lactation. It is especially forbidden to use the drug during the first trimester of pregnancy.
6. If the patient is under 18 years of age.
7. High human sensitivity to benzodiazepines.
8. If the patient complains of a drop in the ability to remember any information.

Some people treated with this medicine have a tendency to make erratic movements. In many patients, myasthenia gravis, dysarthria, and asthenia were noted as side effects.

If this remedy is supposed to be used to cure a person of epilepsy, then you need to know what initial stage treatment course the drug can provoke a serious attack of the disease. In some patients, increased aggressiveness, seizures or the appearance of a feeling of fear were noted.

The drug should not be taken while driving a motor vehicle or performing work that requires concentration and quick reaction. In children, the drug causes depression of the central nervous system. Caution is advised to use this medication under the following circumstances:

1. The patient has renal or hepatic insufficiency.
2. Ataxia of cerebral or spinal type.
3. Predisposition to the abuse of psychotropic drugs.
4. Hyperkinesis and various organic diseases of brain structures.
5. during hypoproteinemia.
6. Depression.
7. If the patient is an elderly person.

A side effect while taking the medication may be worsening normal functioning liver. The main symptom in this case is yellowing of the sclera and skin of the patient. Kidney function may be impaired. Some patients complained of decreased sex drive. This drug may cause allergic reactions. A long course of treatment with Phenazepam leads to addiction.

What negative effects can this remedy cause in patients?

Side effects of Phenazepam are as follows:

1. Constant craving for sleep.
2. Violation of coordination of movements.
3. The person becomes lethargic.
4. The work of the brain is noticeably slowed down.
5. Falling down physical activity sick.

Some patients stated that they were visited by various visions. But most of the people treated by doctors with Phenazepam experienced sleep disturbance. This medicinal product may Negative influence for blood production. In this case, there is a shortage of red blood cells, which leads to an increase in the number of platelets and white blood cells. The patient's body reacts with a fever. A person happens sharp rise body temperature, lethargy covers it. Treatment of diseases with Phenazepam often negatively affects work gastrointestinal tract patient. In this case, he begins to salivate profusely, vomiting and heartburn develop.

In many patients, this leads to an aversion to the proposed food, causes constipation or diarrhea.

Patients have a sharp drop in blood pressure blood vessels, body weight falls, the rhythm of the heart muscle may be disturbed. This drug adversely affects the development of the central nervous system of the fetus, if future mother takes the drug.

The nature of the side effect and its frequency in to a large extent depend on the dose taken, the duration of treatment and the individual sensitivity of the person. If appeared adverse events, then you need to stop taking this remedy. Before you start using Phenazepam, you need to get advice from your doctor.

Hello, today we will talk with you, perhaps, about the most famous fear pill we have called phenazepam. I want to say right away that the article is purely educational, i.e. I am not agitating anyone to take or not to take this drug, but just share my subjective opinion. So, I think that it is most logical to start the article with general information about this drug, and at the end I will write about my attitude to phenazepam and publish reviews of those people who directly took it.

What it is?

Phenazepam is a highly active tranquilizer that has a pronounced anticonvulsant, hypnotic and muscle relaxant (reducing the tone of skeletal muscles) action.

Release form

One tablet: 0.5 mg, 1 mg and 2.5 mg.

One plate contains 10 or 25 tablets. In one carton 2 or 5 plates (25 or 10 tablets).

Polymer jars (50 tablets each). In one carton - 1 jar.

Indications for use

I think that from the definition at the beginning of the article it is clear what these magic pills are directed against, but for show I will write again:

• conditions that are accompanied by fear;
• emotional instability;
• autonomic dysfunction and sleep disorders;
• prevention of states of fear and emotional stress;
• anticonvulsant.

You can familiarize yourself with the testimony in more detail.

Contraindications

• hypersensitivity;
• angle-closure glaucoma (predisposition or acute attack);
• severe chronic obstructive pulmonary disease;
• severe depression (suicidal tendencies are observed);
• during breastfeeding;
• coma;
• myasthenia gravis;
• severe alcohol poisoning, sleeping pills;
• pregnancy;
• teenage and childhood up to 18 years;

Side effects

Central and peripheral nervous system:

Most often: at the beginning of treatment (especially in the elderly) - drowsiness, dizziness, ataxia, unsteady gait, confusion, feeling tired, decreased ability to concentrate, disorientation, slowing mental and motor reactions.

Rare: headache, depression, memory loss, mood depression, asthenia ( fatigue), dysarthria (difficulty in speech), euphoria, tremor, impaired coordination of movements (especially at high doses), dystonic extrapyramidal reactions (uncontrolled movements, including the eyes), muscle weakness, epileptic seizures(in patients with epilepsy).

Very rare: various paradoxical reactions that are directly opposite to the action of the drug (fear, anxiety, muscle spasms etc.).

Digestive system

Dry mouth or drooling, nausea, decreased appetite, abnormal liver function, jaundice, heartburn, vomiting, constipation or diarrhea.

Hematopoietic organs

Leukopenia (decrease in the number of white blood cells in the blood), chills, sore throat, weakness, thrombocytopenia (decrease in the number of platelets), neutropenia (decrease in the number of neutrophils), pyrexia, excessive fatigue, anemia (decrease in the number of functional red blood cells) .

allergic reactions

Itching, skin rash.

genitourinary system

Urinary incontinence, impaired renal function, dysmenorrhea, urinary retention, decreased or increased libido.

Other

Most often: drug dependence, addiction.

Rarely: blurred vision, tachycardia (rapid heartbeat), weight loss.

withdrawal syndrome

Most often: irritability, sleep disturbances, spasm of smooth muscles of internal organs and skeletal muscles, increased sweating, nausea, tremors, convulsions, perceptual disturbances, nervousness, dysphoria (low mood), depersonalization, depression, vomiting, tachycardia.

Rare: acute psychosis.

Overdose

Symptoms

Severe drowsiness, decreased reflexes, nystagmus, bradycardia, shortness of breath, coma, marked depression of consciousness, cardiac and respiratory activity, prolonged confusion, prolonged dysarthria, tremor, shortness of breath.

Treatment

Symptomatic therapy, appointment activated carbon, maintenance of respiratory and cardiovascular activity, gastric lavage, control of vital body functions.

Specific antagonist

Flumazenil (in a hospital setting) - in / in 0.2 mg (if necessary - up to 1 mg) in 5% glucose solution or 0.9% sodium chloride solution.

Instructions for use

The drug is released by prescription and is administered orally.

A single dose of phenazepam is usually 0.0005 - 0.001 g (0.5 - 1 mg), and for sleep disorders 0.00025 - 0.0005 g (0.25 - 0.5 mg) 20-30 minutes before bedtime.

For the treatment of neurotic, psychopathic, neurosis-like and psychopathic conditions, the initial dose is 0.0005-0.001 g (0.5-1 mg) 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 0.004-0.006 g per day (4-6 mg), the morning and daily dose is 0.0005-0.001 g, at night 0.0025 g. agitation, fear, anxiety, treatment begins with a dose of 0.003 g (3 mg) per day, rapidly increasing the dose until a therapeutic effect is obtained.

In neurological practice, in diseases with increased muscle tone, the drug is prescribed at 0.002 - 0.003 g (2 - 3 mg) once or twice a day.

The average daily dose of phenazepam is 0.0015 - 0.005 g (1.5 - 5 mg), it is divided into 3 or 2 doses, usually 0.5 - 1.0 mg in the morning and afternoon and up to 2.5 mg at night. The maximum daily dose is 0.01 g (10 mg). The duration of the course of treatment is up to 2 months. When the drug is discontinued, the dose is reduced gradually.

Phenazepam is compatible with other drugs (hypnotics, anticonvulsants, etc.), however, it is necessary to take into account the mutual potentiation of their action.

Price

Price in Russia: about 80 rubles.

Price in Belarus: about 20,000 rubles.

And you can see the availability of the drug in pharmacies in Russian cities.

Reviews

Feedback that I collected on various forums (including forums dedicated to social phobia).

Review #1: I took phenazepam for about a year, he helped me a lot, I finally felt like a man, got a job. But it is almost impossible to refuse it - the longer you take it, the less you cope with situations that you used to cope with without it. You become calm like a “tank”, and without it then it’s just a nightmare, any rustle frightens you, it becomes unbearable and you take the pill again. I started taking 1 tablet 2 times a week, then 2. For 2 days it gives a relaxing effect. By coincidence, I had to give it up, the waste was terrible, but I managed, but without it I’m sitting at a “broken trough” again, I want to start taking it again, because I already forgot how it feels to be calm ... I agree that this is probably the only drug that soothes almost completely, but the "fee" for it is high. Here is such a dilemma, to get hooked on it thoroughly without thinking about the consequences, or to cope on your own, everyone chooses for himself.

Feedback #2: Phenazepam is a complete tin. I talked with doctors, they say that this is a drug of the past generation (it’s clear, it’s still in Soviet time was). It contains a substance that accumulates in the body, and it is not excreted (!). It all accumulates in the tissues and naturally does not internal organs healthier. In addition, dependence on it appears quickly, it is impossible to get off it. I saw all this with my own eyes in my relative, how she went to a psycho. some dispensary where she was prescribed it and every few months she went there for a couple of days, they did a procedure to remove dependence on him, really, like drug addicts. And then after a couple of weeks she started drinking it again and so on in a circle. Moreover, this was officially established - they are prescribed, and then removed with other drugs and taken again. There were many bad changes, as they later said, precisely against the background of phenazepam. It changes the pressure, so it pumps from it, it is harmful of course for the vessels, primarily the brain, which is why changes can occur with long-term use - up to glitches. Of course, it's up to you, but in my opinion there are more safe drugs, a new generation, which at least elementarily do not plant a liver.

Review #3: I only need phenazepam private clinic prescribed. The rest of the doctors did not advise at all, tk. getting used to it (already written) and a person, in order to maintain the desired effect, must constantly increase the dose. It is beneficial for the private sector. In this way they keep the patient on short leash: they constantly adjust the dose, assure that the treatment is not finished and cut down money from the client. Also, it is bad for the heart. In general, I took this rubbish in meager doses for a week and quit ...

Review #4: This morning I drank a wheel of phenazepam, initially dry mouth and when I went out to smoke it was cold, but I didn’t seem to notice anything, but after half an hour I went to the store, again for cigarettes (to the supermarket) and calmly went in, bought with important view. Even the formidable guards from whom I usually turn away, in fact, did not affect me in any way, I don’t know ... maybe it was just an illusion or a hair dryer works like that.

Review #5: There was a time when I drank phenazepam according to the situation. Social phobia practically did not decrease from him, it was just special condition as if you are "in a dream".

Review #6: I have been taking phenazepam 1.5 mg for over a year now and do not feel the need to increase the dose. I tried to reduce slowly, but after a decrease of more than 0.5 mg, I feel an increase in anxiety and muscle tension. I just don't know of any other way to relieve these symptoms. Although I really want to do without any psychotropic drugs. I went to several psychotherapists, but it was not possible to solve this problem.

Review #7: Clogs the liver. It is addictive and as a result - an increase in the dose. With alcohol - up to complete loss of memory for some segments of events. Memory sits forever. When you try to get off, the fun begins: irritability, aggression, breakdowns, nightmares in a dream. I got off with expensive vodka gradually. For 9 years now I have not touched either a hair dryer or vodka, but sometimes those days make themselves felt. The memory was phenomenal, I tried to restore it, but I could not restore it to its former level. Sometimes everything is fine and suddenly a memory gap. I don’t remember where I put the rag or some other nonsense.

Review #8: I drank phenazepam a couple of times in my life. The reaction is strange. Firstly, when I start to fall asleep, for some reason, the muscles begin to contract convulsively, through a dream I lie and twitch and wake up myself from these twitches. In the morning, it’s generally tin ... Parts of the body do not obey. I can walk and my legs can give way, then I can’t take a cup at all - I look at it, but my hand does not rise. Creepy.

Review #9: I drank more than once. It helps me a lot. And now, sometimes, I drink occasionally. For example, once every two weeks I can drink if I can’t sleep for a long time or I have an important meeting. You can get hooked on it, but believe me, it won’t take a week or even two or three…

Review #10: In her youth she dabbled in phenazepam, relanium, sibazon. I don't recommend it very much. When the soul hurts and all that - you take a pill, like in a cocoon, and you are calm as an oyster. And then you notice that there are lapses in memory. Now, over the years, I regret it, because the brain obviously wedges sometimes. Some events of the past cannot be restored - they were in reality or I invented it myself. Some events tell me and I sincerely wonder what happened to me. So take something softer.

Review #11: Phenazepam should not be taken much and often. I got used to it already after three or four days of taking it. It really is a drug. Without him, then everything seems so terrible and gloomy, but with him it’s so cozy and calm ...

Review #12: And about getting used to phenazepam. I drank at night in a row for three months. First 0.5, then 0.25. It was at the direction of the doctor. No addiction. Now I drink only when necessary, that is, not in courses. It still helps.

Review #13: Guys! I don’t want to drink phenazepam to the enemy ... I started drinking it 7-8 years ago, the doctors did not warn that you could get hooked. And I drank it (then it helped a lot with anxiety) at 2 mg. in a day. But when I naively stopped drinking it after 6 months of its heavy use, I realized that I had hit it ... I still drink that I just haven’t tried - there’s no sense nervous system, liver, heart, the body as a whole really planted ... Do not try to drink it - it helps very well at first, and then you will not notice how you will eat it all the time and reproach yourself for having started drinking it ... Believe me - I am writing from my own bitter experience ...

Review #14: I have been taking phenazepam for several years, but in very reasonable doses (1 mg.), And only at night. Shorter packs (50) tab. enough for 4-5 months. I recently took a break for 2.5 months. The most important thing is not to abuse it, do not increase doses, and drink in extreme cases and then you can live. Although I started taking it almost every day (the neurologist wrote it out, due to a depressed state in the morning). Then, based on the experience of taking it, I decided not to abuse it, although some kind of dependence nevertheless appeared. So my advice is to use it only in extreme cases at night, and in minimum doses Oh.

Review #15: Of course, phenazepam will not change your life. It will only temporarily save you from critical moments ( panic attacks, tantrums, hangover syndrome and so on.). I myself, taking it for about 10 years, try not to go beyond 1 - 1.5 tablets per week. 6 pieces can be drunk once (well, maybe twice) in a lifetime. Next is replanting on pills, which could not be worse ...

Review #16: Hairdryer is not satisfied with the fact that this is a single-acting drug. He doesn't heal. And it is better to drink it immediately before disturbing social. situations. Perhaps my mistake was that I drank the course, gradually increasing the dose. The addiction came very quickly.

Review #17: I personally have been taking it for about 5-6 years now. On the second day after the evening reception, it will relax, and, as it were, there will be a slight euphoria. But over time, this effect will weaken, i.e. the body becomes addictive, the result - it is necessary to increase the dose, as with drugs.

Review #18: I have never taken phenazepam, but my mother started taking it a long time ago without our knowing it. Now she has developed a strong addiction, her consciousness and reason have gone crazy. They tried to throw away the pills from her, but according to her sources, she bought them again and drank. Now our life is hell. Tip: if you really need a tranquilizer, then drink better than valerian, but it is better not to touch phenazepam at all.

My attitude to phenazepam

To be honest, to drug treatment I am rather negative, because if you just constantly swallow pills, then in fact nothing will change, you will only muffle the symptoms, but you will not get rid of the problem itself. Another thing is when they are used in conjunction with psychotherapy, in such cases, it seems to me, there should be a result. But again, let me remind you that I am not a doctor and this is just my subjective reasoning.

Now let's move on to phenazepam. Judging by the reviews, you can get hooked on it very quickly, and it acts on the principle of a drug - over time, you will have to increase the dose each time to reach desired effect. Many write about memory lapses, and I think that it is not without reason that phenazepam is a prohibited drug in some countries. Therefore, personally, I, most likely, would never try this rubbish (unless in some hopeless situation), which I advise you. If you really want to overcome your fear, then phenazepam is clearly not for you.

"Phenazepam" is a tranquilizer belonging to the group of benzodiazepine derivatives. It has a pronounced hypnotic, muscle relaxant, anticonvulsant and anxiolytic effect. The effect of anticonvulsant, narcotic, sleeping pills, ethyl alcohol under the influence of the drug "Phenazepam". The instruction describes the pharmacokinetics of the drug: there is a good absorption of the drug from the gastrointestinal tract when taken orally. Moreover, the maximum level of reaching the concentration of Phenazepam in the blood occurs after 1-2 hours, its half-life is 6-10 hours, which is carried out mainly through the kidneys.

Indications for the use of the drug "Phenazepam"

The instruction to the medicinal product lists the diseases in which the reception is indicated this medicine:

• treatment of epilepsy, tics, various hyperkinesis, athetosis, muscle rigidity;
• removal of substance abuse and alcohol withdrawal, various origins seizures;
• various psychopathic and psychopathic, neurosis-like, neurotic states, accompanied frequent drops mood and increased irritability), fear, anxiety.

Contraindications to taking the drug "Phenazepam"

The instructions for the drug warns that this medicine is contraindicated in people with severe myasthenia gravis, as well as with impaired functional activity of the kidneys and (or) liver, severe depression, coma, angle-closure glaucoma, shock, respiratory failure. In addition, it is forbidden to take the remedy for alcohol intoxication, drugs, hypnotics, neuroleptics, other tranquilizers, during pregnancy, at a minor age, in the presence of hypersensitivity to the components of the drug.

The drug "Phenazepam". Compound

Each white tablet contains:

• phenazepam (0.0025, 0.001, 0.0005 g);
• gelatin;
• talc;
• milk sugar;
• calcium stearate;
• starch.

Each package contains tablets in a blister of 100 or 50 pieces.

How to take the drug "Phenazepam"? Instruction

With extreme caution, the drug is prescribed to people involved in potentially dangerous species activities that require responsiveness and heightened attention as well as the elderly.

Start taking the drug with minimal doses (from 0.5 to 1 mg) two to three times a day. Further, the dosage is increased to 2-5 mg. A subsequent increase in the dose of the drug, reaching up to 10 mg, is possible only under the supervision of the attending doctor in a hospital.

The medicine "Phenazepam". Side effects

As a result therapeutic treatment by using this drug can sometimes occur adverse reactions such as dizziness, nausea, muscle weakness, drowsiness. In particular rare cases may cause mydriasis and ataxia. Even if one of the above symptoms occurs, it is necessary to urgently stop therapy with the drug and immediately consult a doctor.

Overdose medicinal product Phenazepam may cause symptoms such as shortness of breath and shortness of breath, decreased blood pressure blood, decreased reflex ability, bradycardia, confusion, increased drowsiness, coma. That is why in this case it is necessary to call an ambulance, shown symptomatic treatment and gastric lavage.

Recommendations for the appointment of the drug "Phenazepam" can only be done qualified specialist, it is imperative to consult with a psychotherapist who has the right to decide whether it is necessary to take this medication in a particular case.