Hyoscine butylbromide - instructions for use, description, pharmacological action, indications for use, dosage and method of administration, contraindications, side effects.
Included in the preparations
ATX:A.03.B.B.01 Hyoscine butyl bromide
Pharmacodynamics:Blocks m-cholinergic receptors, reducing the stimulating effect of acetylcholine: reduces the secretion of lacrimal, bronchial, sweat, gastric glands, as well as the exocrine activity of the pancreas. How an antispasmodic reduces tone bile ducts and gallbladder, gastrointestinal tract, and at the same time increases sphincter tone. Improves atrioventricular conduction, causes tachycardia. Makes it difficult to churn intraocular fluid, increases intraocular pressure, provokes paralysis of accommodation.
Pharmacokinetics:After oral administration on an empty stomach, up to 8% is absorbed into gastrointestinal tract. The maximum concentration in blood plasma is achieved after 2 hours, after 5 minutes - after intravenous administration. Plasma protein binding is 4.4%.
Metabolism in the liver.
The half-life is 6 hours. Elimination in feces and kidneys.
Indications:Used to treat gastric ulcers and duodenum. Used for cholelithiasis, biliary and renal colic, spasm smooth muscle gastrointestinal tract, acute pancreatitis, dysmenorrhea, hemorrhoids and fissure anus.
XI.K20-K31.K25 Stomach ulcer
XI.K20-K31.K26 Duodenal ulcer
XI.K20-K31.K31.3 Pylorospasm, not elsewhere classified
XI.K80-K87.K80 Cholelithiasis[cholelithiasis]
XI.K80-K87.K81.0 Acute cholecystitis
XI.K80-K87.K81.1 Chronic cholecystitis
XI.K80-K87.K82.8 Other specified gallbladder diseases
XIV.N20-N23.N23 Renal colic, unspecified
XIV.N80-N98.N94.5 Secondary dysmenorrhea
XIV.N80-N98.N94.4 Primary dysmenorrhea
XVIII.R10-R19.R10.4 Other and unspecified abdominal pain
XI.K55-K63.K60.2 Anal fissure, unspecified
XI.K94.K94* Diagnosis of gastrointestinal diseases
XIV.N80-N98.N94.6 Dysmenorrhea, unspecified
Contraindications:Keratoconus, synechiae of the iris, closed-angle and open-angle glaucoma, individual intolerance.
Carefully:Coronary heart disease, polyneuropathy, hypertonic disease, diaphragmatic hernia, hypersensitivity.
Pregnancy and lactation:FDA Recommendations - category C. Use with caution during pregnancy and lactation in cases where the expected benefit outweighs the risk to the fetus and newborn. At long-term use suppresses lactation.
Dosage and administration:Use in children
Intravenously slowly emergency indications: 0.3-0.6 mg/kg up to 12 years of age. Maximum daily dose is 1.5 mg/kg body weight.
From 12 years: intravenously slowly, intramuscularly or subcutaneously, 20-40 mg (1-2 ampoules).
inside in children over 6 years of age, adult doses are used.
Adults
Orally, 10-20 mg 3-5 times a day.
Rectally, 1-2 suppositories (10-20 mg) 3 times a day.
Intravenously slowly, subcutaneously, intramuscularly, 20-40 mg (1-2 ampoules).
Highest daily dose: 100 mg.
Higher single dose: 40 mg.
Side effects:Central and peripheral nervous system : dizziness, drowsiness, hallucinations, impaired tactile sensitivity.
The cardiovascular system : tachycardia.
Digestive system : dry mouth, constipation.
Sense organs: mydriasis, paralysis of accommodation, photophobia.
Urinary system : urinary retention.
Allergic reactions.
Overdose:Motor and speech agitation, blurred vision, drowsiness, unsteadiness of gait, hallucinations, depression of the respiratory center.
Treatment. Administration of physostigmine (intravenously from 0.5 to 2 mg at a rate of up to 1 mg/min, not more than 5 mg per day) or neostigmine methyl sulfate (intramuscularly 1 mg every 2-3 hours, intravenously - up to 2 mg).
Interaction:Antacids containing aluminum or calcium carbonate reduce the absorption of the drug in the gastrointestinal tract. It is recommended to maintain an interval of at least 1 hour.
When used simultaneously with phenylephrine, the development of arterial hypertension is possible.
Reduces the concentration of levodopa in the blood plasma, reduces or eliminates the effect anticholinesterase drugs and m-cholinomimetics. Simultaneous use with atropine increases side effects.
Special instructions:Use of the drug in conditions elevated temperature air can cause heatstroke.
InstructionsHyoscyamine butyl bromide – active substance, which is considered a plant alkaloid, representing an ammonium compound found in the following representatives of the flora: belladonna, scopolia, as well as henbane and dope. When extracted from the plant, this compound forms a crystalline powder. white, which easily dissolves in water and alcohol.
pharmachologic effect
The active substance hyoscine butyl bromide is found in some medicines ah, which have an m-anticholinergic effect, as well as some antispasmodic effects.
This plant compound blocks the so-called m-cholinergic receptors. Preparations containing this substance have atropine-like effects, which is expressed in the form of dilated pupils, accommodation paralysis occurs, intraocular pressure may increase slightly, tachycardia occurs, and AV conduction increases.
In addition, smooth muscle fibers relax digestive tract, as well as the biliary tract and urinary tract, uterus, bronchi, in addition, hyoscine butyl bromide slows down peristaltic processes, reduces the secretory function of the sweat, salivary and mucous glands.
During internal use preparations containing this plant alkaloid in their composition, it is poorly absorbed from the digestive tract, in addition, it has low binding to plasma proteins.
Indications for use
I will list when products containing butyl bromide in hyoscine are indicated for use:
For spastic conditions of the gastrointestinal tract, as well as the biliary tract and genitourinary, such as intestinal, biliary and renal colic, and cholecystitis;
With dyskinesia of the biliary tract of a spastic nature;
For peptic ulcer disease occurring directly in the acute phase;
An effective remedy for algodismenorrhea (painful menstruation).
When conducting endoscopic examination digestive tract to relax muscles.
Contraindications for use
Among the contraindications can be noted increased sensitivity to hyoscine butyl bromide, as well as to other belladonna alkaloids, in addition, the drug is not used for closed-angle glaucoma, as well as before the age of six and for the so-called megacolon ( pathological increase large intestine).
Among the restrictions on the use of hyoscine butyl bromide preparations, one can note the suspicion of intestinal obstruction; blockage urinary tract, including with prostate adenoma; at cardiological pathology, in particular with the so-called atrial fibrillation.
Application and dosage
Medicines containing this substance can be used orally, and they can also be administered rectally, while the dosage medication selected individually by a qualified doctor.
Adults and children over the age of six are usually prescribed the drug at a dosage of 10 to 20 milligrams three to five times a day. Rectally, the drug is used in the same dose, which is equivalent to one or two suppositories up to three times a day.
Side effects
I will list what are possible side effects in response to the use of drugs containing the active substance hyoscine butylbromide: there is some drowsiness, amnesia (memory loss), accommodation disturbance, glaucoma, increased eye sensitivity to bright light, dryness of the pharynx and oral cavity is added, constipation is noted, in addition, nausea and vomiting.
Others are possible unwanted manifestations as allergic reactions dermatological nature, such as itching, rash, redness and swelling skin, anaphylactic conditions with difficulty breathing are not excluded. In addition, there is a decrease in sweating, dry skin, as well as tachycardia.
Overdose
In case of overdose will be noted following symptoms: dilated pupils, dry mucous membranes, lack of reaction to light, difficulty swallowing, convulsions, tachycardia, hyperthermia joins, impaired consciousness, hallucinations, CNS depression are not excluded, in addition, respiratory arrest, as well as paresis Bladder and intestines.
In this case, the patient is given next treatment: first of all, the stomach should be washed, after which the patient is given activated charcoal and magnesium sulfate, forced diuresis is prescribed, physostigmine is administered every hour or galantamine.
To eliminate intestinal paresis, as well as tachycardia, the patient is prescribed neostigmine methyl sulfate, magnesium sulfate is indicated for convulsions, in addition, mechanical ventilation is effective, and so on.
Preparations containing hyoscine butyl bromide
The active substance hyoscine butyl bromide is found in medication Buscopan, Hyoscin, and also Spanil. Listed medications are produced by the pharmaceutical industry in the form of tablets, which are coated on top with a thin shell, in addition, there are rectal suppositories and a solution that is recommended for injection.
Conclusion
The use of products containing this plant alkaloid should be carried out on the recommendation qualified specialist. The patient should independently study the instructions for the use of the prescribed drug.
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Description
Detailed descriptionPharmacotherapeutic group: m-Anticholinergics Nosological classification (ICD-10): K25 Gastric ulcer K26 Duodenal ulcer K31.3 Pylorospasm, not classified elsewhere K59.8.1* Intestinal dyskinesia K81 Cholecystitis K82.8.0* Dyskinesia of the gallbladder and biliary tract K94* Diagnosis of gastrointestinal diseases N23 Renal colic, unspecified N94.6 Dysmenorrhea, unspecified R10.4 Other and unspecified pain in the abdominal area
Detailed description
pharmachologic effect
Blocks m-cholinergic receptors. Causes atropine-like effects: dilated pupils, paralysis of accommodation, increased intraocular pressure, increased heart rate, acceleration of sinoatrial and AV conduction, stimulates the automatism of the sinus node and functional activity AV node, relaxes the smooth muscles of the gastrointestinal tract, biliary and urinary tracts, uterus, bronchi, slows down peristalsis, reduces the secretion of excretory glands (salivary, mucous, sweat).
After oral administration, it is poorly absorbed from the gastrointestinal tract. Protein binding is low.
Contraindications
Hypersensitivity (including to other belladonna alkaloids), angle-closure glaucoma, myasthenia gravis, megacolon, childhood up to 6 years old.
Use during pregnancy and breastfeeding
Possibly if the expected effect of therapy exceeds the potential risk to the fetus or child.
Side effects
From the outside nervous system and sense organs: drowsiness, amnesia, impaired accommodation, increased eye sensitivity to light, exacerbation of glaucoma.
From the gastrointestinal tract: dryness of the mucous membrane of the mouth and pharynx, constipation, nausea and vomiting.
Allergic reactions: skin manifestations, anaphylaxis with episodes of difficulty breathing.
Others: dry skin, redness of the skin, tachycardia, difficulty urinating, decreased sweating.
Interaction
Enhances the m-anticholinergic effect of tricyclic antidepressants (including amitriptyline, clomipramine, imipramine), H 1 -antihistamines, quinidine, amantadine, disopyramide, other m-anticholinergics (including ipratropium bromide, tiotropium bromide). Concomitant use hyoscine butyl bromide and dopamine antagonists (for example, metoclopramide) leads to a weakening of the effect on the gastrointestinal tract of both drugs. Hyoscine butylbromide increases the risk of beta-adrenergic-induced tachycardia.
Overdose
Symptoms: dilated pupils and lack of reaction to light, dry mucous membranes, hoarseness, difficulty swallowing, tachycardia, hyperthermia, skin flushing, impaired consciousness, hallucinations, convulsions, followed by CNS depression, respiratory arrest, intestinal and bladder paresis.
Treatment: gastric lavage with activated carbon and then with 15% magnesium sulfate, forced diuresis, repeated administrations physostigmine (every 0.5–1 h) or galanthamine (every 1–2 h), to eliminate intestinal paresis and tachycardia, it is possible to administer neostigmine methyl sulfate, with moderate arousal and not severe cramps- magnesium sulfate; in severe cases - sodium oxybate, oxygen therapy, mechanical ventilation; for difficulty urinating - catheterization of the bladder. Patients with glaucoma - instillation of pilocarpine, if necessary, systemic administration of cholinomimetics is possible.
Analogues of the drug hyoscine butyl bromide are presented, in accordance with medical terminology, called "synonyms" - drugs that are interchangeable in terms of effects on the body, containing one or more of the same active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.
Description of the drug
Hyoscine butyl bromide- M-cholinergic receptor blocker. Decreases smooth muscle tone internal organs, reduces them contractile activity. Causes a decrease in the secretion of exocrine glands. Increases heart rate. Causes mydriasis, paralysis of accommodation, increases intraocular pressure.List of analogues
Note! The list contains synonyms of hyoscine butyl bromide having similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.
Reviews
Below are the results of surveys of visitors to the site about the drug hyoscine butylbromide. They reflect the personal feelings of the respondents and cannot be used as official recommendation when treated with this drug. We strongly recommend that you contact a qualified medical specialist to select a personal course of treatment.Visitor survey results
Visitor Performance Report
Visitor Report of Side Effects
Information has not yet been providedOne visitor reported an estimate of the cost
| Participants | % | ||
|---|---|---|---|
| Dear | 1 | 100.0% | |
Two visitors reported frequency of intake per day
How often should I take Hyoscine butylbromide?Most respondents most often take this drug 3 times a day. The report shows how often other survey participants take this drug.
One visitor reported an expiration date
How long does it take to take Hyoscine butylbromide to feel an improvement in the patient's condition?In most cases, survey participants felt an improvement in their condition after 1 day. But this may not correspond to the period after which you will begin to improve. Check with your doctor for how long you need to take this medicine. The table below shows the results of the survey on the initiation of effective action.
| Participants | % | ||
|---|---|---|---|
| 1 day | 1 | 100.0% | |
Visitor report on reception time
Information has not yet been providedEight visitors reported the patient's age
Visitor reviews
There are no reviews |
Official instructions for use
There are contraindications! Read the instructions before useBUSKOPAN
| Features and Benefits |
Registration number:
P N014393/01Trade proprietary name: Buscopan
MNI or group name: Hyoscine butyl bromide
Dosage form:
film-coated tabletsCompound:
1 tablet contains 10 mg hyoscine butyl bromideExcipients: calcium hydrogen phosphate anhydrous (calcium hydrogen phosphate) 33 mg; dried corn starch 30 mg; soluble starch (hydrolyzed potato starch) 2 mg; colloidal silicon dioxide 4 mg; tartaric acid 0.5 mg; stearic acid 0.5 mg.
Shell: povidone (polyvinylpyrrolidone) 0.505 mg; sucrose 41.182 mg; talc 23.671 mg; gum arabic (acacia gum) 2.761 mg; titanium dioxide 1.802 mg; macrogol 6000 (polyethylene glycol) 0.055 mg; carnauba wax 0.012 mg; white wax (white beeswax) 0.012 mg.
Description: White, round, biconvex tablets, sugar-coated. The smell is almost imperceptible
Pharmacological group: m-anticholinergic
ATX code:А03ВВ01
Pharmacological properties
It has a local antispasmodic effect on the smooth muscles of internal organs (gastrointestinal tract, biliary tract, urinary tract), reduces the secretion of the digestive glands. The local antispasmodic effect is explained by the ganglion-blocking and antimuscarinic activity of the drug. Being a quaternary ammonium derivative, Hyoscine butyl bromide does not penetrate the blood-brain barrier, therefore there is no anticholinergic effect on the central nervous system.Pharmacokinetics
Being a quaternary ammonium derivative and having a high polarity, Hyoscine butyl bromide is slightly absorbed from the gastrointestinal tract. After oral administration, absorption of the drug is 8%. The average absolute bioavailability is less than 1%. After a single oral administration of hyoscine butyl bromide in doses of 20-400 mg, mean peak plasma concentrations were reached after approximately 2 hours and ranged from 0.11 to 2.04 ng/ml. Due to its high affinity for muscarinic and nicotinic receptors, hyoscine butyl bromide is distributed mainly in muscle cells organs abdominal cavity and small pelvis, as well as in the intramural ganglia of the abdominal organs. The connection with plasma proteins (albumin) is low and amounts to about 4.4%. It was established that the drug (at a concentration of 1 mmol) in vitro interacts with the transport of choline (1.4 nmol) in epithelial cells human placenta.
The terminal half-life of the drug after a single oral dose of 100-400 mg ranged from 6.2 to 10.6 hours. Metabolism is carried out mainly by hydrolysis of the ester bond. After oral administration, excretion of the drug occurs in feces and urine. After oral administration of the drug: renal elimination is from 2 to 5%, elimination through the intestines is 90%. Renal excretion of hyoscine butyl bromide metabolites is less than 0.1% of the dose. After oral administration of the drug in doses of 100-400 mg, the average clearance values range from 881 to 1420 l/min, while the corresponding volumes of distribution for the same dose range vary from 6.13 to 11.3 x 10 5 l, which may be explained low systemic bioavailability.
Metabolites excreted in the urine weakly bind to muscarinic receptors, so they are not active and do not have pharmacological properties.
Indications for use
Renal colic, biliary colic, spastic dyskinesia of the biliary tract and gallbladder, cholecystitis, intestinal colic, pylorospasm, peptic ulcer stomach and duodenum in the acute phase (as part of complex therapy), algodismenorrhea.Contraindications
Hypersensitivity to hyoscine butyl bromide or any other component of the drug. Myasthenia gravis, megacolon.Children under 6 years old.
Pregnancy, lactation period.
A buscopan tablet contains 41.2 mg of sucrose. The maximum recommended daily dose (10 tablets) contains 411.8 mg of sucrose. Patients with rare hereditary disorders(fructose intolerance), such as glucose-galactose malabsorption or sucrase-isomaltase deficiency, should not take the drug.
Carefully
The drug should be prescribed with caution in the following clinical situations: suspicion of intestinal obstruction(including pyloric stenosis); obstruction of the urinary tract (including benign hyperplasia prostate gland), tachyarrhythmias (including atrial fibrillation), angle-closure glaucoma.
In cases where abdominal pain of unknown origin continues or intensifies, or when symptoms such as fever, nausea, vomiting, changes in stool consistency and frequency of bowel movements, abdominal tenderness, decreased blood pressure, fainting, or blood in the stool, you should seek medical attention immediately. medical consultation.
Fertility, pregnancy and lactation
Data on the use of the drug during pregnancy and on the penetration of the drug and its metabolites into breast milk limited.
There have been no studies on the effect of the drug on fertility.
As a precautionary measure, use of the drug during pregnancy and lactation is not recommended.
Directions for use and doses
Inside.Unless otherwise prescribed by your doctor, it is recommended next mode dosing:
Adults and children over 6 years of age: 1-2 tablets 3-5 times a day with water.
The drug should not be used daily for more than 3 days without consulting a doctor.
Side effects
Many of the above unwanted effects may be associated with the anticholinergic properties of the drug. Anticholinergic side effects are usually mild and self-limiting.
From the immune system:
Anaphylactic shock, anaphylactic reactions, shortness of breath, skin reactions(eg, urticaria, rash, erythema, pruritus) and other manifestations of hypersensitivity
From the cardiovascular system:
Tachycardia
From the digestive system:
Dry mouth
For the skin and subcutaneous tissues:
Dyshidrotic eczema
The information on the page was verified by the therapist Vasilyeva E.I.
Structural formula
Russian name
The Latin name of the substance is Hyoscine butyl bromide
Hyoscini butylbromidum ( genus. Hyoscini butylbromidi)chemical name
9-Butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azonium tricyclononane bromide
Gross formula
C21H30BrNO4Pharmacological group of the substance Hyoscine butyl bromide
Nosological classification (ICD-10)
CAS code
149-64-4Characteristics of the substance Hyoscine butyl bromide
Semi-synthetic derivative of hyoscyamine, an alkaloid found in belladonna, henbane, dope, scopolia; quaternary ammonium compound. White crystalline powder, easily soluble in water, soluble in alcohol. Molecular weight - 440.38.
Pharmacology
pharmachologic effect- antispasmodic, m-anticholinergic.Blocks m-cholinergic receptors. Causes atropine-like effects: dilated pupils, accommodation paralysis, increased intraocular pressure, increased heart rate, accelerated sinoatrial and AV conduction, stimulates the automatism of the sinus node and the functional activity of the AV node, relaxes the smooth muscles of the gastrointestinal tract, bile and urinary tract, uterus, bronchi, slows down peristalsis , reduces the secretion of excretory glands (salivary, mucous, sweat).
After oral administration, it is poorly absorbed from the gastrointestinal tract. Protein binding is low.
Application of the substance Hyoscine butyl bromide
Spastic conditions of the gastrointestinal tract, biliary and genitourinary tract ( renal colic, biliary colic, cholecystitis, intestinal colic, pylorospasm), spastic biliary dyskinesia and gallbladder, peptic ulcer of the stomach and duodenum in the acute phase (as part of complex therapy), algomenorrhea, endoscopic and functional diagnostic studies digestive organs (to relax smooth muscles).
Contraindications
Hypersensitivity (including to other belladonna alkaloids), angle-closure glaucoma, myasthenia gravis, megacolon, children under 6 years of age.
Restrictions on use
Suspicion of intestinal obstruction (including pyloric stenosis), obstruction of the urinary tract (including prostate adenoma), a tendency to tachyarrhythmias (including tachyarrhythmia atrial fibrillation).
Use during pregnancy and breastfeeding
Possibly if the expected effect of therapy exceeds the potential risk to the fetus or child.
Side effects of the substance Hyoscine butyl bromide
From the nervous system and sensory organs: drowsiness, amnesia, impaired accommodation, increased eye sensitivity to light, exacerbation of glaucoma.
From the gastrointestinal tract: dryness of the mucous membrane of the mouth and pharynx, constipation, nausea and vomiting.
Allergic reactions: skin manifestations, anaphylaxis with episodes of difficulty breathing.
Others: dry skin, redness of the skin, tachycardia, difficulty urinating, decreased sweating.
Interaction
Enhances the m-anticholinergic effect of tricyclic antidepressants (including amitriptyline, clomipramine, imipramine), H 1 -antihistamines, quinidine, amantadine, disopyramide, and other m-anticholinergics (including ipratropium bromide, tiotropium bromide). The combined use of hyoscine butyl bromide and dopamine antagonists (for example, metoclopramide) leads to a weakening of the effect of both drugs on the gastrointestinal tract. Hyoscine butylbromide increases the risk of beta-adrenergic-induced tachycardia.
Overdose
Symptoms: dilated pupils and lack of reaction to light, dry mucous membranes, hoarseness, difficulty swallowing, tachycardia, hyperthermia, skin flushing, impaired consciousness, hallucinations, convulsions, followed by CNS depression, respiratory arrest, intestinal and bladder paresis.
Treatment: gastric lavage with activated charcoal and then with 15% magnesium sulfate, forced diuresis, repeated administration of physostigmine (every 0.5-1 hour) or galantamine (every 1-2 hours), to eliminate intestinal paresis and tachycardia, it is possible to administer neostigmine methyl sulfate, with moderate agitation and mild convulsions - magnesium sulfate; in severe cases - sodium oxybate, oxygen therapy, mechanical ventilation; for difficulty urinating - bladder catheterization. For patients with glaucoma, instillation of pilocarpine; if necessary, systemic administration of cholinomimetics is possible.
Precautions for the substance Hyoscine butyl bromide
It is necessary to take into account significant differences in individual sensitivity to hyoscine, incl. possibility of agitation and hallucinations when taking usual doses in individual patients. Risk side effects increases in old age. Alcohol consumption is prohibited during treatment. Overheating should be avoided when performing intense activities. physical activity and in hot weather, as well as hot baths and saunas. During therapy, driving and other activities that require increased speed reactions. To reduce dry mouth you can use chewing gum no sugar, small pieces of ice, saliva substitutes. It should be taken into account that dry mouth that persists for more than 2 weeks increases the risk of diseases of tooth enamel, gums, and fungal infections of the oral cavity. Discontinuation of the drug should be carried out gradually (with rapid withdrawal, nausea, sweating, and dizziness may occur).
