Pantogam 10 percent for children instructions. Pantogam syrup for children: instructions for use and what it is needed for, price, reviews, analogues

It is a nootropic neuroregulatory agent. It is a colorless or yellowish liquid with a cherry odor.

The composition includes: Pantogam (hopantenic acid) - 10.0 g, excipients: glycerin, aspartame, sorbitol, sodium benzoate, citric acid, food flavoring, sterilized water - up to 100 ml.

Syrup 10% in a quantity of 100 ml in a dark glass bottle with a screw cap made of aluminum or plastic is placed together with instructions in a cardboard package, there is also a measuring spoon with a volume of 5 ml and a mark marked “1/2” (corresponding to a volume of 2.5 ml), or a measuring spoon with a volume of 5 ml with marks and marked with the marks “1/4” and “1/2” (corresponding to volumes of 1.25 ml and 2.5 ml).
Pharmacodynamics.

The medicinal effect of Pantogam depends on the content of gamma-aminobutyric acid(abbreviation GABA). In this case, the mechanism of action is due to Pantogam’s ability to influence the GABAB receptor-channel complex.

The syrup has a nootropic and anticonvulsant effect. At the same time, Pantogam is able to increase the brain’s tolerance to hypoxia and toxic effects, it also potentiates anabolic neuronal processes, combines moderate sedative effect and a mild stimulating effect, thereby reducing motor excitability and activating mental and physical performance, raises to some extent the overall vitality, increases the level of vigor.

Pantogam normalizes GABA metabolism in case of chronic alcohol intoxication, including after complete withdrawal of ethanol. The drug acts as an inhibitor of acetylation reactions, which take place in the processes of inactivation of sulfonamides and drugs of the novocaine series, due to this, prolongation of the effects of the latter is achieved. The use of Pantogam syrup leads to stabilization of the pathologically enhanced vesical reflex in the case of neurogenic Bladder.

Pharmacokinetically, Pantogam syrup is quickly absorbed from the gastrointestinal tract and easily penetrates histohematic barriers(including hematoencephalic), the highest concentrations of the drug are concentrated in the liver tissue, stomach walls, kidneys and skin. The drug is not involved in metabolic processes and is excreted unchanged within two days: 67.5% is excreted by the kidneys, 28.5% is excreted through the intestines.

Indications

Due to its properties, Pantogam syrup can be used for a number of pathological neurological conditions.

The drug is prescribed to children with perinatal brain damage from the first days of life, including those accompanied by mental retardation and behavioral disorders. Pantogam can be used in children in cases of impaired psychological status, which is recorded in the form of mental retardation, various speech disorders (including, mainly in clonic form), motor functions and their combinations, including the formation of school skills.

Used to treat neurosis-like conditions (inorganic encopresis, enuresis), as well as neurogenic urination disorders (urgency, urinary incontinence).

Pantogam is indicated for reduced intellectual-mnestic productivity resulting from, in the initial forms of senile (otherwise, senile) organic disorders at various lesions brain (consequences of head injury, intoxication, neuroinfectious).

It is used in cases of extrapyramidal disorders in organic diseases of the brain (with, Huntington's chorea, etc.), and is also used for preventive purposes and for therapy for extrapyramidal syndrome, which was caused by antipsychotics. May be prescribed in conjunction with psychotropic drugs in the treatment of schizophrenia with cerebral organic deficit. In cases of decreased cognitive productivity, it is prescribed together with anticonvulsants.

Pantogam is taken for psycho-emotional overload, including conditions accompanied by a decrease in physical and intellectual performance, to correct memory processes and improve concentration.

Contraindications

Contraindications are allergic reactions for any of the components of the medicinal product. Pantogam is contraindicated if the patient has severe kidney disease.

Not prescribed during pregnancy (especially in the 1st trimester). During lactation - stop breastfeeding.

Mode of application

Pantogam syrup 10% is taken orally, half an hour after meals. Standard single dose for adults it is 2.5-10 ml, the daily dose is approximately 15-30 ml. For children, a single dose is 2.5-5 ml, a daily dose is 7.5-30 ml.

The standard course of therapy with Pantogam syrup lasts from 1 to 4 months. After 3-6 months, a second course of treatment can be carried out. IN pediatric practice Depending on age, the following range of syrup doses is recommended:

children of the first year: up to 10 ml (up to 1 g) per day;
up to 3 years: up to 12.5 ml (up to 1.25 g) per day;
from 3 to 7 years: up to 15 ml (up to 1.5 g);
over 7 years: up to 20 ml (up to 2 g).

According to the treatment schedule, the dose is increased over 7-12 days, then taken at maximum dose for up to forty days or more, then the dose is gradually reduced until discontinuation within 7-8 days. Typically, a course of treatment with Pantogam syrup lasts up to three months (in some cases up to 6 months or more).

In the case of schizophrenia, it is used in combination with psychotropic drugs (the main treatment), the syrup is prescribed in doses of 5 to 30 ml per day. Course duration is from 1 to 3 months. For epilepsy, together with anticonvulsants, the dose is from 7.5 to 10 ml of syrup per day. The duration of the course is up to a year or more.

In the case of neuroleptic syndrome with extrapyramidal disorders, the daily dose of syrup is up to 30 ml, therapy lasts several months. For extrapyramidal hyperkinesis in neurodegenerative conditions, syrup is prescribed at a dose of 5-30 ml per day. The course of treatment is up to 4 months or more.

To restore and improve performance during increased loads, at asthenic conditions Pantogam syrup is prescribed 2.5-5 ml 3 times a day in short courses. For urinary disorders: children are prescribed 2.5-5 ml of syrup, course of treatment for 1-3 months; for adults, dosage is 10 ml 2-3 times a day.

In case of long-term treatment, the simultaneous administration of Pantogam and other nootropics, as well as stimulant drugs, should not be combined. Due to its nootropic effect, Pantogam is taken in the morning and afternoon.

Side effects

Allergic reactions are possible, if they occur, the dose of the drug should be discontinued or reduced. This may include skin rashes, rhinitis, and inflammation of the conjunctiva.

There may also be noise in the head, short-term sleep disturbance, or drowsiness, in which discontinuation of Pantogam in syrup is not required.

Overdose

Overdose is characterized by increased symptoms of side effects. Recommendations for elimination consist of gastric lavage, and you should take Activated carbon, according to indications - symptomatic therapy.

special instructions

Interaction with other drugs

Pantogam has the ability to prolong the effect of barbiturates; it also enhances the effect of anticonvulsants and prevents side effects from phenobarbital, carbamazepine, and antipsychotics. Therapeutic effect Pantogam syrup can be enhanced in combination with glycine, xydiphone. The syrup enhances the effect local anesthetics, which should be remembered in some cases.

Storage conditions

Pantogam is stored at temperatures up to 25 ° C, out of reach of children. The shelf life of the syrup is no more than 2 years. Do not use expired syrup.

Analogs

Drugs with active substance There is quite a lot of hopantenic acid: , Gopantam, calcium hopantenate, etc. Trade names There are no drugs with active ingredients in the form of syrup similar to Pantogam.

Price

Pantogam syrup is a prescription drug. On average, a 100 ml package of Pantogam syrup in pharmacies costs from 320 to 586 rubles.

Self-medication is dangerous. This article is for informational purposes only. Before using Pantogam syrup, consult your doctor!

Composition and release form

Tablets - 1 tablet:

active substance: calcium hopanthenate (Pantogam®) - 250/500 mg;
excipients: methylcellulose - 0.8/1.6 mg; calcium stearate - 3.1/6.2 mg; magnesium hydroxycarbonate - 46.8/93.6 mg; talc - 9.3/18.6 mg.

Tablets, 250 and 500 mg. In a blister pack made of PVC film and aluminum foil, 10 tablets each. 5 contour blister packs are placed in a cardboard pack.

Syrup - 100 ml:

active substance: calcium hopanthenate (Pantogam®) - 10 g;
excipients: glycerol (in terms of 100%) - 25.8 g; sorbitol - 15 g; citric acid monohydrate - 0.1 g; sodium benzoate - 0.1 g; aspartame - 0.05 g; food flavoring “Cherry 667” - 0.01 g; purified water - up to 100 ml.

Syrup, 100 mg/ml. In dark glass bottles of 100 ml, sealed with caps with a control ring for the first opening. Each bottle together with a measuring spoon with a nominal volume of 5 ml with a line marked “1/2” (corresponding to 2.5 ml) or with a measuring spoon with a nominal volume of 5 ml with lines marked “1/4” and “1/2” (which corresponds to 1.25 ml and 2.5 ml) are placed in a cardboard pack.

Description of the dosage form

The syrup is colorless or slightly yellowish, with a cherry smell.

Pills white, flat-cylindrical, with chamfer and notch.

pharmachologic effect

Nootropic.

Pharmacokinetics

After oral administration, it is quickly absorbed into the gastrointestinal tract. Tmax - 1 hour. The highest concentrations are created in the liver, kidneys, stomach wall and skin. Penetrates through the BBB. Not metabolized. Excreted unchanged within 48 hours: 67.5% of dose taken- with urine, 28.5% - with feces.

Pharmacodynamics

A nootropic agent that has neurometabolic, neuroprotective and neurotrophic properties. Increases the brain's resistance to hypoxia and exposure toxic substances, stimulates anabolic processes in neurons, combines moderate sedative effect with a mild stimulating effect, has an anticonvulsant effect, reduces motor excitability while regulating behavior. Increases mental and physical performance. Helps normalize GABA content during chronic alcohol intoxication and subsequent ethanol withdrawal. Shows analgesic effect.

Indications for use

Cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels, senile dementia (initial forms), residual organic brain lesions in individuals mature age and the elderly, cerebral organic insufficiency in patients with schizophrenia, extrapyramidal hyperkinesis in patients with hereditary diseases nervous system(including Huntington's chorea, hepatocerebral dystrophy, Parkinson's disease), residual effects past neuroinfections, post-vaccination encephalitis, traumatic brain injury (including complex therapy); extrapyramidal neuroleptic syndrome (hyperkinetic and akinetic), as a side effect corrector antipsychotics(neuroleptics) and for prophylactic purposes at the same time as “cover therapy”; epilepsy (with slowness mental processes together with anticonvulsants). Psycho-emotional overload, decreased mental and physical performance(increased concentration and memory). Urinary disorders: enuresis, daytime urinary incontinence, pollakiuria, urgency (adults and children over 2 years old).

Children: perinatal encephalopathy, mental retardation(delayed mental, speech, motor development or a combination thereof), children cerebral paralysis, stuttering (mainly clonic form), epilepsy (as part of combination therapy with anticonvulsants, especially for polymorphic seizures and petit mal seizures).

Contraindications for use

Acute serious illnesses kidneys, first trimester of pregnancy.

Use during pregnancy and children

Use is contraindicated in the first trimester of pregnancy.

Application is possible according to the dosage regimen.

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes.

Drug interactions

Prolongs the effect of barbiturates, enhances the effects of anticonvulsants, nootropics and central nervous system stimulants, and the effect of local anesthetics (procaine).

Prevents side effects phenobarbital, carbamazepine, antipsychotics (neuroleptics).

The effect of hopantenic acid is enhanced in combination with glycine and xydiphone.

Dosage

Inside, 15-30 minutes after eating.

Common for tablets

Adults: single dose - 0.25-1 g, daily dose - 1.5-3 g; children: single dose - 0.25-0.5 g, daily dose - 0.75-3 g. Course of treatment - 1-4 months, in some cases - up to 6 months. After 3-6 months, a second course of treatment is possible.

For tablets 250 mg

For epilepsy: in combination with anticonvulsants - 0.75-1 g/day. The course of treatment is up to 1 year or more.

For extrapyramidal neuroleptic syndrome: in combination with ongoing therapy, daily dose - up to 3 g, treatment for several months.

With extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system: ( combination treatment) - 0.5-3 g/day. The course of treatment is up to 4 months or more.

For the consequences of neuroinfections and head injury: 0.25 g 3-4 times a day.

To restore performance under increased loads and asthenic conditions: 0.25 g 3 times a day.

For the treatment of extrapyramidal syndrome caused by taking antipsychotics: adults - 0.5-1 g 3 times a day; children - 0.25-0.5 g 3-4 times a day. The course of treatment is 1-3 months.

For tics: for children - 0.25-0.5 g 3-6 times a day, for 1-4 months.

For urination disorders: adults - 0.5-1 g 2-3 times a day; children - 0.25-0.5 g (daily dose - 25-50 mg/kg). The course of treatment is 1-3 months.

Children with various pathologies nervous system: depending on age, the drug is recommended in a dose of 1-3 g. Tactics for prescribing the drug: increasing the dose over 7-12 days, taking the maximum dose for 15-40 days and gradual decline doses before discontinuation of Pantogam® for 7-8 days. The break between courses of Pantogam®, as for any other nootropic drug, ranges from 1 to 3 months.

For tablets 500 mg

For cognitive impairment organic lesions brain, incl. for the consequences of neuroinfections and head injury, and neurotic disorders: 0.25 g 3-4 times a day.

For extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with ongoing therapy: in a dose of 0.5 to 3 g per day. The course of treatment is up to 4 months or more.

For the treatment of extrapyramidal syndrome caused by taking antipsychotics: adults - in a dose of 0.5 to 1 g 3 times a day; children - in a dose of 0.25 to 0.5 g 3-4 times a day. The course of treatment is 1-3 months.

For epilepsy with slowing of mental processes in complex therapy with anticonvulsants: adults - in a dose of 0.5 to 1 g 3 times a day; children - in a dose of 0.25 to 0.5 g 3-4 times a day. The course of treatment is up to 6 months.

For psycho-emotional overload, decreased mental and physical performance, to improve concentration and memory: 0.25 g 3 times a day.

For neurogenic urination disorders: adults - in a dose of 0.5 to 1 g 2-3 times a day; children - in a dose of 0.25 to 0.5 g 3 times a day (daily dose is 25-50 mg/kg). The course of treatment is 1-3 months.

For children with various pathologies of the nervous system: depending on age, the drug is recommended to take up to 3 g per day (6 tables). Tactics for prescribing the drug: increasing the dose over 7-12 days, taking the maximum dose for 15-40 days and gradually reducing the dose until Pantogam® is discontinued over 7-8 days. The break between courses of Pantogam®, as for any other nootropic drug, ranges from 1 to 3 months.

Children with developmental delay: 0.5 g 3-4 times a day. The course of treatment is 2-3 months.

For children with attention deficit hyperactivity disorder: depending on body weight, the drug is prescribed in average therapeutic dose 30 mg/kg per day, morning and afternoon, with dose titration over the first 5-7 days. The course of treatment is 3-4 months.

For children with neurosis-like conditions (tics; stuttering, mainly in the clonic form): in a dose of 0.25 to 0.5 g 3-6 times a day. The course of treatment is 1-4 months.

Taking into account the nootropic effect of the drug, it is preferably taken in the morning and afternoon (up to 17:00).

Adults: single dose - 2.5-10 ml (0.25-1 g), daily dose - 15-30 ml (1.5-3 g); children: single dose - 2.5-5 ml (0.25-0.5 g), daily dose - 7.5-30 ml (0.75-3 g). The course of treatment is 1-4 months, sometimes up to 6 months. After 3-6 months, a second course of treatment is possible.

For children, depending on age and pathology of the nervous system: the following dose range is recommended: children of the first year - 5-10 ml (0.5-1 g) per day, up to 3 years - 5-12.5 ml (0.5- 1.25 g) per day, children from 3 to 7 years old - 7.5-15 ml (0.75-1.5 g), over 7 years old - 10-20 ml (1-2 g). Treatment tactics include increasing the dose over 7-12 days, taking the maximum dose for 15-40 days or more, with a gradual dose reduction until discontinuation within 7-8 days. The course of treatment is 30-90 days (with certain diseases up to 6 months or more).

For schizophrenia: in combination with psychotropic drugs- from 5 to 30 ml (0.5-3 g) per day. The course of therapy is from 1 to 3 months.

For epilepsy in combination with anticonvulsants: in a dose of 7.5 to 10 ml (0.75-1 g) per day. The course of therapy is up to 1 year or more.

For neuroleptic syndrome accompanied by extrapyramidal disorders: daily dose - up to 30 ml (up to 3 g), treatment for several months.

For extrapyramidal hyperkinesis in patients with organic diseases of the nervous system: from 5 to 30 ml (0.5-3 g) per day. The course of treatment is up to 4 months or more.

For the consequences of neuroinfections and head injury: from 5 to 30 ml (0.5-3 g) per day.

To restore performance under increased stress and asthenic conditions: 2.5-5 ml (0.25-0.5 g) 3 times a day.

For urination disorders: children - 2.5-5 ml (0.25-0.5 g), daily dose - 25-50 mg/kg, course of treatment - 1-3 months; adults - 5-10 ml (0.5-1 g) 2-3 times a day.

Precautionary measures

The drug Pantogam is used primarily for the treatment pathological conditions in the area of the nervous system of various origins. The release of the drug in the form of syrup is intended for the treatment of young patients who, unfortunately, are also not immune from similar pathologies. The drug has been used in medicine for quite a long time and has managed to earn a reputation as an effective and relatively safe drug.

Pantogam syrup instructions

The instructions included with the drug describe in detail the spectrum of action of Pantogam syrup. By carefully studying it, you can get a clear idea of how the syrup works. So, to list it beneficial effects included:

Protecting the brain from oxygen starvation and exposure to toxic substances.
Strengthening anabolic processes in brain neurons.
Mild stimulation with simultaneous moderate sedative effect.
Improving memory and mental activity while simultaneously influencing and regulating behavior.
Possessing neurometabolic and neuroprotective properties.
Impact on increasing mental and physical activity.
The ability to normalize the content of gamma-aminobutyric acid in chronic alcoholics;
The ability to have a moderate analgesic effect.

The use of the drug Pantogam syrup is indicated for the following ailments:

At perinatal encephalopathy in children from birth;
At various forms CB paralysis in children;
When braking at mental development various degrees, including those with behavioral disorders;
When the psychological status of children is disturbed as a general delay in mental development, and also when speech has specific disorders, during the formation of school skills (reading, writing, counting, etc.);
For hyperkinetic disorders, including hyperactivity syndrome, accompanied by a lack of attention development;
In conditions characterized as neurosis-like (stuttering, being in a predominantly clonic form, tic, inorganic encopresis and enuresis);
With a decrease in mnestic-intellectual productivity as a result of arteriosclerotic changes in cerebral vessels, with initial form senile dementia, organic brain damage, which may be associated with consequences of a traumatic, toxic, neuroinfectious nature;
In schizophrenia with the presence of cerebral organic insufficiency;
For extrapyramidal disorders in organic brain disease;
For epilepsy;
In cases of psycho-emotional overload, as well as decreased performance, both mental and physical, in order to improve concentration and memory ability;
For urinary disorders at the neurogenic level.

Pantogam syrup instructions for use

Syrup 10% Pantogam should be taken orally after meals no earlier than 30 minutes later.

For adults, the usual dose per dose consists of 2.5 milliliters - 10 milliliters, the daily dosage is from 15 milliliters to 30 milliliters;

Children are allowed to take from 2.5 milliliters to 5 milliliters in a single dose; daily dosage from 7.5 milliliters to 30 milliliters;

Course treatment may have a duration of: one – four months or up to six months;

After 3 months, it is possible to conduct a second treatment course.

For children based on age and the presence of pathologies of the nervous system, it is recommended to adhere to the following dosage range:

Children from birth to one year - from 5 to 10 milliliters per day;
Children under 3 years of age - from 5 to 12.5 milliliters per day;
Children from 3 years to 7 years of age - from 7.5 milliliters to 15 milliliters per day;
Children over 7 years of age - from 10 to 20 milliliters per day.

Treatment tactics may include increasing the dose over a week or two, then taking the maximum dose for fifteen to forty days, after which the dose can be gradually reduced until the drug is discontinued for another week.

The course of treatment is from one to three months. Some diagnoses require a six-month course of treatment or even more.

Schizophrenia in combination with psychotropic drugs a - from 5 milliliters to 30 milliliters per day. Course treatment is from one to three months.

Epilepsy in combination with anticonvulsant drugs- from 7.5 milliliters to 10 milliliters per day. Course treatment - up to a year or more.

Neuroleptic syndrome accompanied by extrapyramidal disorders– in a daily dose - up to 30 milliliters, course treatment for several months.

Extrapyramidal hyperkinesis in patients with organic disease CNS- from 5 milliliters to 30 milliliters per day. Course treatment is four or more months.

For the consequences of neuroinfection and traumatic brain injury- from 5 milliliters to 30 milliliters per day.

In order to restore functionality with increased load and asthenic condition, the drug is prescribed 2.5 milliliters - 5 milliliters three times a day.

In case of urination disorder in children:

2.5 milliliters - 5 milliliters in a daily dose of the drug from 25 to 50 micrograms per kilogram of body weight;
course treatment from one to three months;
for adults - 5 milliliters - 10 milliliters several times a day.

At long-term treatment It is not advisable to simultaneously prescribe the drug with other nootropics and stimulants. Due to the fact that Pantogam is a nootropic, it is recommended to take it preferably in the morning and throughout the day.

Pantogam syrup for children

The drug Pantogam is prescribed to children only in the form of syrup, at least to those children who have not reached the age of three.

Emergence side effects it is not observed in children taking the drug. Unless it's drowsiness and sleep disturbance. However, those who did not take medicine later than 16 o'clock in the afternoon and they did not complain about such manifestations.

Pantogam for babies

Whether to use medicine to treat newborns or not, such a decision can only be made by a doctor. Since no mother is able to notice deviations in the development of her baby from the first days of his life.

Many mothers of infants are wary of such prescriptions and even neglect them, not giving the child medicine. Of course, each mother motivates this in her own way, but even if the doctor played it safe and prescribed the drug unnecessarily, the syrup will not harm the baby, since it has virtually no effect side effects. But if the problem really exists, then the drug is quite capable of coping with it. And here it’s worth thinking about whether, to please your fears, it’s worth depriving your child of what he needs. medical care. And is the price of taking the medicine so high if we compare it with the set of possible negative consequences which can result from inaction.

Moreover, its prescription for infants is quite reasonable in the presence of serious pathologies:

At birth injuries, which are obtained during childbirth in the area of the nervous system;
For lesions that occurred during pregnancy in the nervous system;
For epilepsy or convulsive readiness;
In the presence of childhood central paralysis or hydrocephalus;
In case of brain damage as a result of trauma;
For sleep disorders;
With excessive excitability of the nervous system.

It is possible for infants to take Pantogam only in the form of syrup, and the daily dose should be divided into two doses. Duration of treatment and required dosage Only a doctor can determine medications.

However, we should not forget that the baby should take the medicine no earlier than a quarter of an hour after feeding.

Pantogam syrup price

Of course, the cost of the drug will depend largely on the form in which it is released, as well as on many other factors regarding delivery, trade markup, and so on. However, if you are interested in syrup specifically, you can say that on average across the country you can buy 10% Pantogam syrup for approximately 350 rubles.

Pantogam syrup reviews

Opinions about the drug Pantogam syrup are quite contradictory. Someone really praises the drug and talks about it high efficiency and virtually no side effects. But there are also those who did not notice any effect and speak with caution about the safety of the drug.

Parents of infants often completely refuse to give their child medicine, citing their refusal as mistrust of the doctor and his lack of sufficient experience to make such a diagnosis. But they themselves allegedly do not see anything in the child. Sometimes such a frivolous attitude is costly for both parents and the baby. Here are the most latest reviews about the drug:

Elena: I first heard about the drug at an appointment with a neurologist and decided to visit a doctor with two year old child when I realized that for his age, my son speaks very poorly. The syrup was taken for a month and a half. I was pleased with the result. The child began to construct complete sentences and became more willing to engage in conversation. And another bonus - the baby stopped wetting the bed at night. Good drug By the way, no side effects! I recommend.

Lyudmila: We were prescribed the drug upon discharge from the hospital. Although we followed everything as prescribed and there was no dosage or regimen special effect did not notice. My daughter was very restless and remains so. In addition, the syrup has a terribly cloying taste, almost to the point of bitterness. My daughter developed rashes on her face. I began to dilute the syrup a little with water. I'm not happy with the drug, but the doctor probably knows better.

Victoria: By the age of seven months, my daughter lost restful sleep. We decided to immediately consult a doctor. The neurologist prescribed syrup for treatment. After reading the instructions and indications for use, I hesitated for a long time to give it to her. But they still began to be treated. I noticed improvements already on the third day. The child began to sleep!!! And me too.

Instructions for use

Pantogam instructions for use

Dosage form

Syrup, with cherry flavor

Compound

calcium salt of hopantenic acid 10 g/flask

Excipients: glycerol - 25.8 g, sorbitol - 15 g, citric acid monohydrate - 0.1 g, sodium benzoate - 0.1 g, aspartame - 0.05 g, food flavor "Cherry 667" - 0.01 g, purified water - up to 100 ml.

Pharmacodynamics

The spectrum of action of the drug Pantogam® is associated with the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action is due to the direct influence of Pantogam on the GABAB receptor-channel complex.

The drug has a nootropic and anticonvulsant effect.

The drug increases the brain's resistance to hypoxia and exposure to toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability. activates mental and physical performance. Improves GABA metabolism during chronic alcohol intoxication and after ethanol withdrawal. It is capable of inhibiting acetylation reactions involved in the mechanisms of inactivation of procaine (novocaine) and sulfonamides, thereby prolonging the action of the latter.

Causes inhibition of the pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

Suction

Rapidly absorbed from the gastrointestinal tract.

Distribution

The highest concentrations are created in the liver, kidneys, stomach wall, and skin. Penetrates through the BBB.

Metabolism and excretion

It is not metabolized and is excreted unchanged within 48 hours. 67.5% of the dose taken is excreted by the kidneys, 28.5% - with feces.

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes are possible (discontinuation of the drug or dose reduction may be required).

Other: possible sleep disturbances or drowsiness, noise in the head (these symptoms are usually short-lived and do not require discontinuation of the drug).

Selling Features

prescription

Special conditions

Impact on the ability to drive vehicles and operate machinery

In the first days of taking the drug, care should be taken when administering vehicles and mechanisms, taking into account the possible occurrence of drowsiness

Indications

Cognitive impairment in organic brain lesions (including consequences of neuroinfections and traumatic brain injuries) and neurotic disorders;

Schizophrenia with organic cerebral insufficiency;

Cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels;

Extrapyramidal disorders (including myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease), as well as for the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) caused by taking antipsychotics;

Epilepsy with slowing of mental processes in complex therapy with anticonvulsants;

Psycho-emotional overload, decreased mental and physical performance (to improve concentration and memory);

Neurogenic urinary disorders (pollakiuria, urgency, imperative urinary incontinence, enuresis);

Children with perinatal encephalitis

Contraindications

Acute severe kidney disease;

Pregnancy;

Lactation;

Phenylketonuria (for syrup, because it contains aspartame);

Hypersensitivity to the drug.

Drug interactions

Pantogam® prolongs the effect of barbiturates and enhances the effects of anticonvulsants.

At joint use Pantogam® prevents the side effects of phenobarbital, carbamazepine, and neuroleptics.

The Pantogam effect increases when simultaneous use with glycine, etidronic acid.

Pantogam® potentiates the effect of local anesthetics (procaine).

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Mode of application

Dosage

For children, a single dose is 0.25-0.5 g, daily - 0.75-3 g.

The course of treatment is 1-4 months, sometimes up to 6 months. After 3-6 months, you can repeat the course of treatment.

For schizophrenia (in combination with psychotropic drugs), the drug is prescribed in a dose of 0.5-3 g/course of treatment - from 1 to 3 months.

For epilepsy (in combination with anticonvulsants), the drug is prescribed in a dose of 0.75 g to 1 g per day. The course of treatment is up to 1 year or more.

For extrapyramidal neuroleptic syndrome (in combination with ongoing therapy), the dose is up to 3 g. Treatment is carried out over several months.

For extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (in combination with ongoing therapy), 0.5 g to 3 g per day is prescribed. The course of treatment is up to 4 months or more.

For the consequences of neuroinfections and traumatic brain injuries - 0.25 g 3-4

To restore performance under increased loads and asthenic conditions, Pantogam is prescribed 0.25-0.5 g 3

For the treatment of extrapyramidal syndrome caused by taking antipsychotics, adults - 0.5-1 g 3, children - 0.25-0.5 g 3-4 The course of treatment is 1-3 months.

For tics in children - 0.25-0.5 g 3-6 for 1-4 months.

For urinary disorders, adults are prescribed the drug in a dose of 0.5-1 g 2-3, children - 0.25-0.5 g (daily dose is 25-50 mg/kg). The course of treatment is 1-3 months.

For children with various pathologies of the nervous system, depending on age, the following dose range is recommended: children of the first year of life - 0.5-1 g/, children under 3 years of age - 0.5-1.25 g/, children from 3 to 7 years of age - 0.75-1.5 g /, children over 7 years old - 1-2 g/ The tactics of prescribing the drug is to gradually increase the dose over 7-12 days, take the maximum dose for 15-40 days and gradually reduce the dose over 7-8 days until complete withdrawal Pantogama. The course of treatment is 30-90 days (for some diseases up to 6 months or more).

The break between courses of Pantogam is 1-3 months (as for any other nootropic drug).

Taking into account the nootropic effect of the drug, it is taken in the morning and afternoon (up to 17:00).

Available in two dosage forms in tablets of 0.25 g and syrup of 100 mg/ml. The syrup is a colorless or slightly yellowish liquid with a pleasant cherry flavor.

It is released in a dark glass bottle, which is packaged in a paper box.

Each bottle comes with a measuring spoon and detailed instructions by application. The active substance is hopantenic acid.

Mechanism of action and pharmacokinetics

The therapeutic effect of Pantogam syrup is due to the presence of γ in its structure -aminobutyric acid(GABA). The drug has a nootropic and anticonvulsant effect.

Active substance increases the brain's resistance to oxygen deficiency and the effects of toxins, activates anabolic reactions in neurons, combines a moderate calming effect with a mild stimulating effect, eliminates excessive motor activity, increases mental and physical activity.

Normalizes GABA metabolism in patients chronic alcoholism. Besides, active principle inhibits the process of acetylation, which is involved in the mechanisms of inactivation of procaine and sulfonamides, as a result, prolongation of their action is observed. When taking the medication, the bladder reflex and detrusor tone are normalized.

At oral intake syrup is quickly adsorbed from digestive tract. The active substance migrates through the BBB, the maximum concentration is observed in skin, liver, in the walls of the stomach, kidneys. The medicine is excreted within 2 days in its original form with urine (67.5%) and with feces (28,5%).

Application area

Pantogam syrup is prescribed for the following pathologies:

For what pathologies should you stop using it?

You should stop taking the syrup if you experience following states and diseases:

individual intolerance;
serious kidney pathologies in the acute stage;
pregnancy up to 13 weeks;
phenylketonuria, since one of excipients syrup is aspartame.

Prescriptions for special categories of patients

Pantogam syrup can be prescribed for newborns from the first day of life. Their dosage is selected individually depending on the age of the patient and his general well-being.

The drug should not be prescribed to patients with severe kidney pathologies.

You should not take the medicine in the first trimester, when the bookmark is in progress. internal organs fetus

Undesirable effects and cases of overdose

Despite the fact that in adults, taking Pantogam can provoke emotional breakdowns, sleepwalking, in children from adverse reactions only allergic processes are observed in the form of conjunctivitis, rhinitis, skin manifestations. In this case, immediate discontinuation of treatment and prescription of antihistamines is required.

If the dosage of the medication for a child is chosen incorrectly, then unwanted reactions from the brain may occur, such as:

excitability or vice versa;

If the above described phenomena develop, it is necessary to reduce the dosage of the drug.

In case of intentional or accidental overdose of syrup, an increase in negative reactions from the spinal cord and brain (tinnitus, headaches).

In this case, gastric lavage and the use of adsorbents (Polysorb, Smecta, Neosmectin) are indicated. Treatment is symptomatic; there is no specific antidote.

Pharmaceutical interactions

The active substance Pantogam enhances the effect of anticonvulsants, prolongs therapeutic effect from barbiturates. When taken in parallel, it levels out unwanted reactions from antipsychotic drugs.

When used simultaneously, it potentiates the effect of local anesthetics such as novocaine.

The therapeutic effect of the drug is enhanced if it is taken simultaneously with etidronic acid.

Dosage regimen

Pantogam syrup is allowed to be taken by children from birth. It should be taken 30 minutes after feeding. Since the drug has a nootropic effect, it is better to take it in the first half of the day.

Dosage and duration of treatment pediatrician Each child is selected individually, depending on the pathology of the central nervous system and age:

in children under 1 year the daily dose can vary from 5 to 10 ml (500-1000 mg);
up to 3 years from 5 to 12.5 ml;
up to 7 years from 7.5 to 15 ml;
schoolchildren from 10 to 20 ml.

A single dose for children of any age should be 2.5-5 ml, maximum daily dosage 3 years

The course of treatment can vary from 1 to 4 months, and sometimes up to six months. The next appointment is acceptable after 3-6 months.

During the first 7-12 days of use, the dose should be gradually increased, then within 15-40 days the drug should be taken at the maximum recommended dosage, then for a week daily dose gradually reduce until completely abolished.

Syrup dosages depending on the disease:

During long-term treatment with Pantogam syrup, you should not take other drugs at the same time, as it may increase negative effects from each of them.