Pantogam 10 percent for children instruction. Pantogam syrup for children: instructions for use and what it is for, price, reviews, analogues

It is a nootropic neuroregulatory agent. It is presented as a colorless or yellowish liquid with a cherry smell.

The composition includes: Pantogam (hopantenic acid) - 10.0 g, excipients: glycerin, aspartame, sorbitol, sodium benzoate, citric acid, food flavor, sterilized water - up to 100 ml.

Syrup 10% in the amount of 100 ml in a dark glass bottle, with a screw cap made of aluminum or plastic, is placed together with the instructions in a cardboard box, there is also a measuring spoon with a volume of 5 ml and a risk marked "1/2" (corresponding to a volume of 2.5 ml), or a measuring spoon with a volume of 5 ml with risks and marked with the marks "1/4" and "1/2" (corresponding to volumes of 1.25 ml and 2.5 ml).
Pharmacodynamics.

The medicinal effect of Pantogam depends on the content in its composition. gamma-aminobutyric acid(abbreviation for GABA). At the same time, the mechanism of action is due to the ability of Pantogam to influence the GABAB receptor-channel complex.

The syrup has a nootropic and anticonvulsant effect. At the same time, Pantogam is able to increase the tolerance of the brain to hypoxia and to toxic effects, it also potentiates anabolic neuronal processes, combines moderate sedative effect and a mild stimulating effect, thereby reducing motor excitability and activating mental and physical performance, raises to some extent the general vitality, increases the level of vigor.

Pantogam normalizes GABA metabolism in case of chronic alcohol intoxication, including after the complete abolition of ethanol. The drug acts as an inhibitor of acetylation reactions, which take place in the processes of inactivation of sulfonamides and drugs of the novocaine series, due to this, a prolongation of the effects of the latter is achieved. The use of Pantogam syrup leads to the stabilization of a pathologically enhanced cystic reflex in the case of neurogenic Bladder.

Pharmacokinetically, Pantogam syrup is rapidly absorbed from the gastrointestinal tract, easily penetrates histohematic barriers(including the blood-brain), the highest concentrations of the drug are concentrated in the tissues of the liver, the walls of the stomach, in the kidneys and in the skin. The drug is not involved in metabolic processes and is excreted unchanged within two days: 67.5% is excreted by the kidneys, 28.5% is excreted through the intestines.

Indications

Due to its properties, Pantogam syrup can be used in a number of pathological neurological conditions.

The drug is prescribed for children with perinatal brain damage from the first days of life, including those accompanied by mental retardation and behavioral disorders. Pantogam can be used in children in cases of impaired psychological status, which is fixed in the form of mental retardation, various speech disorders (including predominantly in clonic form), motor functions and their combinations, including the formation of school skills.

It is used to treat neurosis-like conditions (, inorganic encopresis, enuresis), as well as neurogenic urinary disorders (urgent urge, urinary incontinence).

Pantogam is indicated for reduced intellectual-mnestic productivity, formed as a result, with the initial forms of senile (otherwise, senile), organic disorders at various lesions brain (consequences of TBI, intoxication, neuroinfection).

It is used in cases of extrapyramidal disorders in organic diseases of the brain (with, Huntington's chorea, etc.), and is also used for prophylactic purposes and for therapy in extrapyramidal syndrome, which was caused by antipsychotics. May be administered in conjunction with psychotropic drugs in the treatment of schizophrenia with cerebral organic deficiency. When in cases of decreased cognitive productivity, it is prescribed together with anticonvulsants.

Pantogam is taken for psycho-emotional overload, including in conditions accompanied by a decrease in physical and intellectual performance, to correct memorization processes and improve concentration.

Contraindications

Contraindications are allergic reactions to any of the constituents of the medicinal product. Pantogam is contraindicated in patients with severe kidney disease.

It is not prescribed during pregnancy (especially in the 1st trimester). When lactating - stop breastfeeding.

Mode of application

Pantogam syrup 10% is taken orally, half an hour after a meal. Standard single dose for adults is 2.5-10 ml, the daily allowance is approximately equal to 15-30 ml. For children, a single dose of 2.5-5 ml, daily 7.5-30 ml.

The standard course of therapy with Pantogam syrup lasts from 1 to 4 months. After 3-6 months, a second course of treatment can be carried out. IN pediatric practice Depending on age, the following range of doses of syrup is recommended:

children of the first year: up to 10 ml (up to 1 g) per day;
up to 3 years: up to 12.5 ml (up to 1.25 g) per day;
from 3 to 7 years: up to 15 ml (up to 1.5 g);
older than 7 years: up to 20 ml (up to 2 g).

According to the treatment schedule, within 7-12 days the dose is increased, followed by admission to maximum dose for up to forty days or more, then the dose is gradually reduced until canceled within 7-8 days. Usually the course of treatment with Pantogam syrup lasts up to three months (in some cases up to 6 months or more).

In the case of schizophrenia, it is used in combination with psychotropic drugs (main treatment), the syrup is prescribed in doses of 5 to 30 ml per day. The duration of the course is from 1 to 3 months. With epilepsy, together with anticonvulsants, the dose is from 7.5 to 10 ml of syrup per day. The duration of the course is up to a year or more.

In the case of neuroleptic syndrome with extrapyramidal disorders, the daily dose of syrup is up to 30 ml, therapy continues for several months. With extrapyramidal hyperkinesis in neurodegenerative conditions, the syrup is prescribed 5-30 ml per day. The course of treatment is up to 4 or more months.

To restore and improve performance increased loads, at asthenic conditions Pantogam syrup is prescribed 2.5-5 ml 3 times a day in short courses. For urination disorders: children are prescribed 2.5-5 ml of syrup, the course of treatment is 1-3 months; for adults, the dosage is 10 ml 2-3 times a day.

In the case of a long period of treatment, the simultaneous administration of Pantogam and other nootropics, as well as stimulant drugs, should not be combined. Due to the nootropic action, Pantogam is taken in the morning and afternoon.

Side effects

Allergic reactions are possible, upon occurrence of which it is necessary to cancel or reduce the dose of the drug. It can be a rash on the skin, the appearance of rhinitis, inflammation of the conjunctiva.

There may also be noise in the head, a short-term sleep disturbance, or drowsiness, in which the abolition of Pantogam in syrup is not required.

Overdose

Overdose is characterized by increased symptoms of side effects. Recommendations for elimination are gastric lavage, while taking Activated carbon, according to indications - symptomatic therapy.

special instructions

Interaction with other drugs

Pantogam has the ability to prolong the action of barbiturates, it also enhances the action of anticonvulsants and prevents side effects from phenobarbital, carbamazepine, antipsychotics. Therapeutic effect Pantogam syrup can be enhanced in combination with glycine, ksidifon. The syrup enhances the effect local anesthetics which should be kept in mind in some cases.

Storage conditions

Pantogam is stored at temperatures up to 25 ° C, inaccessible to children. The shelf life of the syrup is not more than 2 years. Do not use expired syrup.

Analogues

Preparations with active substance hopantenic acid is quite a lot:, Gopantam, calcium hopantenate, etc. Trade names there are no preparations with the active substance in the form of a syrup similar to Pantogam.

Price

Pantogam Syrup is a prescription drug. A package with Pantogam syrup with a volume of 100 ml costs on average in pharmacies from 320 to 586 rubles.

Self-medication is dangerous. This article is for informational purposes only. Consult your doctor before using Pantogam Syrup!

Composition and form of release

Tablets - 1 tab.:

active substance: calcium hopantenate (Pantogam®) - 250/500 mg;
excipients: methylcellulose - 0.8 / 1.6 mg; calcium stearate - 3.1 / 6.2 mg; magnesium hydroxycarbonate - 46.8 / 93.6 mg; talc - 9.3 / 18.6 mg.

Tablets, 250 and 500 mg. In a blister pack of PVC film and aluminum foil, 10 tab. 5 blister packs are placed in a cardboard box.

Syrup - 100 ml:

active substance: calcium hopantenate (Pantogam®) - 10 g;
excipients: glycerol (in terms of 100%) - 25.8 g; sorbitol - 15 g; citric acid monohydrate - 0.1 g; sodium benzoate - 0.1 g; aspartame - 0.05 g; food flavoring "Cherry 667" - 0.01 g; purified water - up to 100 ml.

Syrup, 100 mg/ml. In dark glass bottles of 100 ml, sealed with lids with a control ring for the first opening. Each vial, together with a measuring spoon with a nominal volume of 5 ml with a score marked "1/2" (corresponding to 2.5 ml) or a measuring spoon with a nominal volume of 5 ml with a score marked "1/4" and "1/2" (corresponding to 1.25 ml and 2.5 ml) are placed in a cardboard box.

Description of the dosage form

The syrup is colorless or slightly yellowish, with a cherry smell.

Pills white color, flat-cylindrical, with a chamfer and risk.

pharmachologic effect

Nootropic.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Tmax - 1 hour. The highest concentrations are in the liver, kidneys, in the wall of the stomach and skin. Penetrates through the BBB. Not metabolized. Excreted unchanged within 48 hours: 67.5% of taken dose- with urine, 28.5% - with feces.

Pharmacodynamics

Nootropic agent, has neurometabolic, neuroprotective and neurotrophic properties. Increases the resistance of the brain to hypoxia and exposure toxic substances, stimulates anabolic processes in neurons, combines moderate sedative effect with a mild stimulating effect, has an anticonvulsant effect, reduces motor excitability while streamlining behavior. Increases mental and physical performance. Contributes to the normalization of the content of GABA in chronic alcohol intoxication and subsequent withdrawal of ethanol. Shows analgesic action.

Indications for use

Cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels, senile dementia (initial forms), residual organic brain lesions in individuals middle age and the elderly, cerebral organic insufficiency in patients with schizophrenia, extrapyramidal hyperkinesis in patients with hereditary diseases nervous system(including Huntington's chorea, hepatocerebral dystrophy, Parkinson's disease), residual effects transferred neuroinfections, post-vaccination encephalitis, craniocerebral injury (as part of complex therapy); extrapyramidal neuroleptic syndrome (hyperkinetic and akinetic), as a side effect corrector antipsychotics(neuroleptics) and prophylactically simultaneously as "cover therapy"; epilepsy (with slowness mental processes together with anticonvulsants). Psycho-emotional overload, decreased mental and physical performance(increased concentration and memory). Urinary disorders: enuresis, daytime urinary incontinence, pollakiuria, imperative urge (adults and children from 2 years).

Children: perinatal encephalopathy, mental retardation(delay of mental, speech, motor development or their combination), children cerebral paralysis, stuttering (mainly clonic form), epilepsy (as part of combination therapy with anticonvulsants, especially in polymorphic seizures and small epileptic seizures).

Contraindications for use

Acute serious illnesses kidneys, I trimester of pregnancy.

Use in pregnancy and children

Contraindicated in the first trimester of pregnancy.

Application is possible according to the dosing regimen.

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes.

drug interaction

Prolongs the action of barbiturates, enhances the effects of anticonvulsants, nootropics and CNS stimulants, the action of local anesthetics (procaine).

Prevents side effects phenobarbital, carbamazepine, antipsychotics (neuroleptics).

The action of hopantenic acid is enhanced in combination with glycine, ksidifon.

Dosage

Inside, 15-30 minutes after eating.

General for tablets

Adults: single dose - 0.25-1 g, daily - 1.5-3 g; children: a single dose - 0.25-0.5 g, daily - 0.75-3 g. The course of treatment - 1-4 months, in some cases - up to 6 months. After 3-6 months, a second course of treatment is possible.

For 250 mg tablets

With epilepsy: in combination with anticonvulsants - 0.75-1 g / day. The course of treatment is up to 1 year or more.

With extrapyramidal neuroleptic syndrome: in combination with ongoing therapy, a daily dose of up to 3 g, treatment for several months.

With extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system: ( combined treatment) - 0.5-3 g / day. The course of treatment is up to 4 months or more.

With the consequences of neuroinfections and TBI: 0.25 g 3-4 times a day.

To restore working capacity at increased loads and asthenic conditions: 0.25 g 3 times a day.

For the treatment of extrapyramidal syndrome caused by taking antipsychotics: adults - 0.5-1 g 3 times a day; children - 0.25-0.5 g 3-4 times a day. The course of treatment is 1-3 months.

With ticks: children - 0.25-0.5 g 3-6 times a day, for 1-4 months.

For urination disorders: adults - 0.5-1 g 2-3 times a day; children - 0.25-0.5 g (daily dose - 25-50 mg / kg). The course of treatment is 1-3 months.

Children with various pathologies nervous system: depending on age, the drug is recommended at a dose of 1-3 g. Tactics of prescribing the drug: increasing the dose within 7-12 days, taking the maximum dose for 15-40 days and gradual decline doses until Pantogam® is canceled within 7-8 days. The break between courses of Pantogam®, as for any other nootropic agent, is from 1 to 3 months.

For 500 mg tablets

With cognitive impairment organic lesions brain, incl. with the consequences of neuroinfections and TBI, and neurotic disorders: 0.25 g 3-4 times a day.

With extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with ongoing therapy: at a dose of 0.5 to 3 g per day. The course of treatment is up to 4 or more months.

For the treatment of extrapyramidal syndrome caused by taking antipsychotics: adults - at a dose of 0.5 to 1 g 3 times a day; children - at a dose of 0.25 to 0.5 g 3-4 times a day. The course of treatment is 1-3 months.

With epilepsy with a slowdown in mental processes in complex therapy with anticonvulsants: for adults - at a dose of 0.5 to 1 g 3 times a day; children - at a dose of 0.25 to 0.5 g 3-4 times a day. The course of treatment is up to 6 months.

With psycho-emotional overload, decreased mental and physical performance, to improve concentration and memory: 0.25 g 3 times a day.

With neurogenic disorders of urination: adults - at a dose of 0.5 to 1 g 2-3 times a day; children - at a dose of 0.25 to 0.5 g 3 times a day (daily dose is 25-50 mg / kg). The course of treatment is 1-3 months.

Children with various pathologies of the nervous system: depending on age, the drug is recommended to take up to 3 g per day (table 6). The tactics of prescribing the drug: increasing the dose within 7-12 days, taking the maximum dose for 15-40 days and gradually reducing the dose until Pantogam® is canceled within 7-8 days. The break between courses of Pantogam®, as for any other nootropic agent, is from 1 to 3 months.

Children with developmental delay: 0.5 g 3-4 times a day. The course of treatment is 2-3 months.

Children with attention deficit hyperactivity disorder: depending on body weight, the drug is prescribed in the average therapeutic dose 30 mg/kg per day, morning and afternoon, with dose titration over the first 5-7 days. The course of treatment is 3-4 months.

Children with neurosis-like conditions (tics; with stuttering, mainly in the clonic form): at a dose of 0.25 to 0.5 g 3-6 times a day. The course of treatment is 1-4 months.

Taking into account the nootropic effect of the drug, it is preferably taken in the morning and afternoon hours (up to 17 hours).

Adults: single dose - 2.5-10 ml (0.25-1 g), daily - 15-30 ml (1.5-3 g); children: single dose - 2.5-5 ml (0.25-0.5 g), daily - 7.5-30 ml (0.75-3 g). The course of treatment is 1-4 months, sometimes up to 6 months. After 3-6 months, a second course of treatment is possible.

Children, depending on the age and pathology of the nervous system: the following dose range is recommended: children of the first year - 5-10 ml (0.5-1 g) per day, up to 3 years - 5-12.5 ml (0.5- 1.25 g) per day, children from 3 to 7 years old - 7.5-15 ml (0.75-1.5 g), over 7 years old - 10-20 ml (1-2 g). The tactics of treatment involves increasing the dose within 7-12 days, taking the maximum dose for 15-40 days or more with a gradual decrease in the dose until cancellation within 7-8 days. The course of treatment is 30-90 days (with certain diseases up to 6 months or more).

For schizophrenia: in combination with psychotropic drugs- from 5 to 30 ml (0.5-3 g) per day. The course of therapy is from 1 to 3 months.

With epilepsy in combination with anticonvulsants: at a dose of 7.5 to 10 ml (0.75-1 g) per day. The course of therapy is up to 1 year or more.

With neuroleptic syndrome accompanied by extrapyramidal disorders: daily dose - up to 30 ml (up to 3 g), treatment for several months.

With extrapyramidal hyperkinesis in patients with organic diseases of the nervous system: from 5 to 30 ml (0.5-3 g) per day. The course of treatment is up to 4 months or more.

With the consequences of neuroinfections and TBI: from 5 to 30 ml (0.5-3 g) per day.

To restore working capacity at increased loads and asthenic conditions: 2.5-5 ml (0.25-0.5 g) 3 times a day.

For urination disorders: for children - 2.5-5 ml (0.25-0.5 g), daily dose - 25-50 mg / kg, course of treatment - 1-3 months; adults - 5-10 ml (0.5-1 g) 2-3 times a day.

Precautionary measures

Pantogam is mainly used to treat pathological conditions in the area of the nervous system various origins. The release of the drug in the form of a syrup is intended for the treatment of small patients, who, unfortunately, are also not immune from similar pathologies. The drug has been used in medicine for a long time and has managed to earn a reputation as an effective and relatively safe drug.

Pantogam Syrup instructions

The instruction attached to the preparation describes in detail the spectrum of action of Pantogam syrup. Having carefully studied it, you can get a clear idea of \u200b\u200bhow the syrup works. So, on the list beneficial effect included:

Brain protection from oxygen starvation and exposure to toxic substances.
Strengthening anabolic processes in brain neurons.
Gentle stimulation with a simultaneous moderate sedative effect.
Improving memory and mental activity while influencing behavior and streamlining it.
Possession of neurometabolic and neuroprotective properties.
Effects on increasing mental and physical activity.
The ability to normalize the content of gamma - aminobutyric acid in chronic alcoholics;
The ability to have a moderate analgesic effect.

The use of the drug Pantogam syrup is indicated for the following ailments:

At perinatal encephalopathy in children from birth;
At various forms CB paralysis in children;
When braking in mental development various degrees, including those with behavioral disorders;
When the psychological status of children is disturbed as a general delay in mental development, as well as when speech has specific disorders, in the formation of school skills (reading, writing, counting, etc.);
With hyperkinetic disorders, including hyperactivity syndrome, accompanied by a lack of attention development;
In conditions characterized as neurosis-like (stuttering, staying in a predominantly clonic form, tic, inorganic encopresis and enuresis);
With a decrease in mnestic-intellectual productivity as a result of arteriosclerotic changes in cerebral vessels, with initial form senile dementia, organic brain damage, which may be associated with the consequences of a traumatic, toxic, neuroinfectious nature;
With schizophrenia with the presence of cerebral organic insufficiency;
With extrapyramidal disorders in organic brain disease;
With epilepsy;
With psycho-emotional overload, as well as a decrease in both mental and physical performance, in order to improve concentration and memorization ability;
With disorders of urination at the neurogenic level.

Pantogam instructions for use syrup

Syrup 10% Pantogam taken orally after meals not earlier than 30 minutes

For adults, the usual dose per dose consists of 2.5 milliliters - 10 milliliters, daily dosage from 15 milliliters to 30 milliliters;

Children in a single dose are allowed to take from 2.5 milliliters to 5 milliliters; daily dosage from 7.5 milliliters to 30 milliliters;

course treatment may have a duration: one - four months or up to six months;

After 3 months, it is possible to conduct a second treatment course.

For children by age and the presence of pathologies of the nervous system, it is recommended to adhere to the following dosage range:

Children from birth to a year - from 5 to 10 milliliters per day;
Children under 3 years of age - from 5 to 12.5 milliliters per day;
Children from 3 years to 7 years of age - from 7.5 milliliters to 15 milliliters per day;
Children over 7 years of age - 10 to 20 milliliters per day.

Treatment tactics may include increasing the dose for a week or two, then taking the maximum for fifteen to forty days, after which you can gradually reduce the dose until the drug is discontinued for another week.

The course of treatment is from one to three months. Some diagnoses require a six-month course of treatment and even more.

Schizophrenia in combination with psychotropic drugs a - from 5 milliliters to 30 milliliters per day. Course treatment - from one to three months.

Epilepsy in combination with drugs against convulsions- 7.5 milliliters to 10 milliliters per day. Course treatment - up to a year or more.

neuroleptic syndrome accompanied by extrapyramidal disorders- in a daily dose - up to 30 milliliters, a course of treatment for several months.

Extrapyramidal hyperkinesis in patients with organic disease CNS- from 5 milliliters to 30 milliliters per day. Course treatment - four or more months.

With the consequences of neuroinfection and traumatic brain injury- from 5 milliliters to 30 milliliters per day.

In order to restore functionality with increased load and asthenic condition, the drug is prescribed 2.5 milliliters - 5 milliliters three times a day.

With a disorder in the process of urination in children:

2.5 milliliters - 5 milliliters in a daily dose of the drug from 25 to 50 micrograms per kilogram of body weight;
course treatment from one to three months;
for adults - 5 milliliters - 10 milliliters several times a day.

At long-term treatment it is not advisable to simultaneously prescribe the use of the drug with other nootropics and stimulants. Due to the fact that Pantogam is a nootropic, it is recommended to take it preferably in the morning and during the day.

Pantogam syrup for children

The drug Pantogam is prescribed to children only in the form of a syrup, at least for those babies who have not reached the age of three.

emergence side effects in children taking the drug, it is not observed. Unless it is drowsiness and sleep disturbance. However, those who did not take medicine later than 4 p.m. and did not complain of such manifestations.

pantogam for babies

Whether to use the medicine for the treatment of newborns or not, only a doctor can make such a decision. Since no mother is able to notice deviations in the development of her baby from the first days of his life.

Many mothers of infants are wary of such appointments and even neglect them, not giving the child medicine. Of course, each of the mothers motivates this in her own way, but even if the doctor played it safe and prescribed the drug without special need, the syrup will not harm the baby, since it practically does not side effects. But if the problem really exists, then the drug is quite capable of coping with it. And here it is worth considering whether, for the sake of your fears, it is worth depriving the child of the necessary medical care. And is the price of taking the medicine so high, if we compare it with a set of possible negative consequences that may result from inaction.

Moreover, its appointment for infants is quite justified in the presence of serious pathologies:

At birth trauma, which are obtained during childbirth in the region of the nervous system;
With lesions that are obtained during pregnancy in the region of the nervous system;
With epilepsy or convulsive readiness;
In the presence of children's CB paralysis or hydrocephalus;
With brain damage as a result of trauma;
With sleep disorders;
With excessive excitability of the nervous system.

It is possible to take Pantogam for infants only in the form of syrup, and the daily dose should be divided into two doses. duration of treatment and the required dosage medicines can only be determined by a doctor.

However, we should not forget that taking the medicine for the baby should be carried out no earlier than a quarter of an hour after feeding.

pantogam syrup price

Of course, the cost of the drug will depend largely on it, on the form in which it is released, as well as on many other factors such as delivery, trade markup, and so on. However, being interested in syrup, we can say that on average in the country you can buy 10% Pantogam syrup for approximately 350 rubles.

Syrup Pantogam reviews

Opinions about the drug Pantogam syrup are quite contradictory. Someone praises the drug very much and talks about it high efficiency and virtually no side effects. But there are those who did not notice any effect and speak about the safety of the drug with caution.

Parents of infants often completely refuse to give their child medicine, motivating their refusal by distrust of the doctor and his lack of sufficient experience to make such a diagnosis. And they themselves, allegedly, do not see anything in the child. Sometimes such a frivolous attitude is costly for both parents and the baby. Here are the most latest reviews about the drug:

Elena: I first heard about the drug at a neurologist's appointment, deciding to visit a doctor with two year old when I realized that for his age, my son speaks very badly. The syrup was taken for a month and a half. The result pleased. The child began to build whole sentences and became more willing to engage in conversation. And one more bonus - the baby stopped wetting the bed at night. Good drug By the way, no side effects! I recommend.

Ludmila: They prescribed the drug to us when we were discharged from the hospital. Although they observed everything as scheduled and the dosage and regimen of taking no special effect did not notice. My daughter was very restless, and remains. In addition, the syrup has a terribly sugary taste, right up to bitterness. My daughter has a rash on her face. I began to dilute the syrup a little with water. I am unhappy with the drug, but the doctor, perhaps, knows better.

Victoria: Daughter by the age of seven months has lost restful sleep. We decided to see a doctor immediately. The neurologist prescribed a syrup for treatment. After reading the instructions and indications for use, for a long time I did not dare to give it to her. However, they started to heal. I noticed improvements on the third day. The baby is sleeping!!! And me too.

Instructions for use

Pantogam instructions for use

Dosage form

Syrup, with cherry flavor

Compound

calcium salt of hopantenic acid 10 g/vial

Excipients: glycerol - 25.8 g, sorbitol - 15 g, citric acid monohydrate - 0.1 g, sodium benzoate - 0.1 g, aspartame - 0.05 g, food flavor "Cherry 667" - 0.01 g, purified water - up to 100 ml.

Pharmacodynamics

The spectrum of action of Pantogam® is associated with the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action is due to the direct influence of Pantogam on the GABAB-receptor-channel complex.

The drug has a nootropic and anticonvulsant effect.

The drug increases the resistance of the brain to hypoxia and exposure toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability. activates mental and physical performance. Improves GABA metabolism in chronic alcohol intoxication and after ethanol withdrawal. It is able to inhibit acetylation reactions involved in the mechanisms of inactivation of procaine (novocaine) and sulfonamides, thereby prolonging the action of the latter.

Causes inhibition of pathologically increased cystic reflex and detrusor tone.

Pharmacokinetics

Suction

Rapidly absorbed from the gastrointestinal tract.

Distribution

The highest concentrations are created in the liver, kidneys, in the wall of the stomach, in the skin. Penetrates through the BBB.

Metabolism and excretion

It is not metabolized and is excreted unchanged within 48 hours. 67.5% of the dose taken is excreted by the kidneys, 28.5% - with feces.

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes are possible (drug withdrawal or dose reduction may be required).

Others: possible sleep disturbances or drowsiness, noise in the head (these symptoms are usually short-lived and do not require discontinuation of the drug).

Selling Features

prescription

Special conditions

Influence on the ability to drive vehicles and control mechanisms

In the first days of taking the drug, care should be taken when administering vehicles and mechanisms, given the possible occurrence of drowsiness

Indications

Cognitive impairment in organic brain lesions (including the consequences of neuroinfections and traumatic brain injuries) and neurotic disorders;

Schizophrenia with organic cerebral insufficiency;

Cerebrovascular insufficiency caused by atherosclerotic changes in cerebral vessels;

Extrapyramidal disorders (including myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease), as well as for the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) caused by taking antipsychotics;

Epilepsy with slowing down of mental processes in complex therapy with anticonvulsants;

Psycho-emotional overload, decreased mental and physical performance (to improve concentration and memorization);

Neurogenic urination disorders (pollakiuria, imperative urges, imperative urinary incontinence, enuresis);

Children with perinatal encephalops

Contraindications

Acute severe kidney disease;

Pregnancy;

Lactation;

Phenylketonuria (for syrup, because it contains aspartame);

Hypersensitivity to the drug.

drug interaction

Pantogam® prolongs the action of barbiturates, enhances the effects of anticonvulsants.

At joint application Pantogam® prevents the side effects of phenobarbital, carbamazepine, neuroleptics.

The effect of Pantogam is enhanced by simultaneous application with glycine, etidronic acid.

Pantogam® potentiates the action of local anesthetics (procaine).

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Mode of application

Dosage

For children, a single dose is 0.25-0.5 g, daily - 0.75-3 g.

The course of treatment is 1-4 months, sometimes up to 6 months. After 3-6 months, you can conduct a second course of treatment.

In schizophrenia (in combination with psychotropic drugs), the drug is prescribed in a dose of 0.5-3 g / day. The course of treatment is from 1 to 3 months.

In epilepsy (in combination with anticonvulsants), the drug is prescribed at a dose of 0.75 g to 1 g per day. The course of treatment is up to 1 year or more.

With extrapyramidal neuroleptic syndrome (in combination with ongoing therapy), the dose is up to 3 g / Treatment is carried out for several months.

With extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (in combination with ongoing therapy), from 0.5 g to 3 g per day is prescribed. The course of treatment - up to 4 months or more.

With the consequences of neuroinfections and craniocerebral injuries - 0.25 g 3-4 each

To restore performance under increased loads and asthenic conditions, Pantogam is prescribed 0.25-0.5 g 3

For the treatment of extrapyramidal syndrome caused by taking antipsychotics, adults - 0.5-1 g 3, children - 0.25-0.5 g 3-4 The course of treatment is 1-3 months.

With ticks in children - 0.25-0.5 g 3-6 times a day for 1-4 months.

In case of urination disorders, the drug is prescribed for adults at a dose of 0.5-1 g 2-3 times, for children - 0.25-0.5 g each (daily dose is 25-50 mg / kg). The course of treatment is 1-3 months.

For children with various pathologies of the nervous system, depending on age, the following dose range is recommended: children of the first year of life - 0.5-1 g / day, children under 3 years old - 0.5-1.25 g / day, children from 3 to 7 years old - 0.75-1.5 g /, children over 7 years old - 1-2 g / The tactics of prescribing the drug consists in gradually increasing the dose over 7-12 days, taking the maximum dose for 15-40 days and gradually reducing the dose over 7-8 days until complete cancellation Pantogam. The course of treatment is 30-90 days (for certain diseases up to 6 months or more).

The break between courses of Pantogam is 1-3 months (as for any other nootropic agent).

Taking into account the nootropic effect of the drug, its administration is carried out in the morning and afternoon hours (up to 17 hours).

Produced in two dosage forms in tablets of 0.25 g and syrup of 100 mg / ml. The syrup is a colorless or slightly yellowish liquid, pleasant in taste with a cherry flavor.

It is released in a dark glass bottle, which is packed in a paper box.

Each vial comes with a measuring spoon and detailed instructions by application. The active substance is hopantenic acid.

Mechanism of action and pharmacokinetics

The therapeutic effect of Pantogam syrup is due to the presence of γ in its structure -aminobutyric acid(GABA). The drug has a nootropic and anticonvulsant effect.

Active substance increases the resistance of the brain to oxygen deficiency and the effects of toxins, activates anabolic reactions in neurons, combines a moderate calming effect with a mild stimulating effect, eliminates excessive motor activity, enhances mental and physical activity.

Normalizes GABA metabolism in patients chronic alcoholism. Besides, active principle inhibits the process of acetylation, which is involved in the mechanisms of inactivation of procaine and sulfonamides, as a result, a prolongation of their action is observed. When taking the medication, the cystic reflex and detrusor tone are normalized.

At oral intake syrup is rapidly adsorbed from digestive tract. The active substance migrates through the BBB, the maximum concentration is observed in skin, liver, in the walls of the stomach, kidneys. The drug is excreted within 2 days in its original form with urine (67.5%) and with stool (28,5%).

Application area

Pantogam syrup is prescribed for the following pathologies:

Under what pathologies should you refuse to use?

It is worth refusing to take the syrup if there are following states and diseases:

individual intolerance;
serious pathologies of the kidneys in the acute stage;
pregnancy up to 13 weeks;
phenylketonuria, as one of excipients syrup is aspartame.

Appointments to special categories of patients

Pantogam syrup can be prescribed for newborns from the first day of life. Their dosage is selected individually, depending on the age of the patient and his general well-being.

The drug should not be prescribed to patients with severe kidney pathologies.

Do not take the drug in the first trimester, when the bookmark is in progress internal organs fetus.

Undesirable effects and cases of overdose

Despite the fact that in adults, taking Pantogam can provoke emotional breakdowns, sleepwalking, in children from adverse reactions only allergic processes are observed in the form of conjunctivitis, rhinitis, skin manifestations. In this case, immediate withdrawal of treatment and the appointment of antihistamines are required.

If the dosage of the drug for the child is chosen incorrectly, then unwanted reactions from the brain may occur, such as:

excitability or vice versa;

With the development of the above phenomena, it is necessary to reduce the dosage of the drug.

With intentional or accidental overdose of syrup, there is an increase negative reactions from the spinal cord and brain (tinnitus, headaches).

In this case, gastric lavage is indicated, the intake of adsorbing agents (Polysorb, Smecta, Neosmectin). Treatment is symptomatic, there is no specific antidote.

Pharmaceutical interaction

The active substance of Pantogam enhances the action of anticonvulsants, prolongs therapeutic effect from barbiturates. At parallel reception levels adverse reactions from antipsychotic drugs.

When used simultaneously, it potentiates the effect of local anesthetics such as novocaine.

The therapeutic effect of the drug is enhanced if it is taken simultaneously with and etidronic acid.

Dosing regimen

Pantogam syrup is allowed to be taken by children from birth. It should be taken 30 minutes after feeding. Since the drug has a nootropic effect, it is better to take it in the morning.

Dosage and duration of treatment pediatrician each child is selected individually, depending on the pathology of the central nervous system and age:

in children under 1 year old the daily dose may vary from 5 to 10 ml (500-1000 mg);
up to 3 years from 5 to 12.5 ml;
up to 7 years from 7.5 to 15 ml;
schoolchildren from 10 to 20 ml.

A single dose for children of any age should be 2.5-5 ml, the maximum daily dosage 3 y.

The course of treatment can vary from 1 to 4 months, and sometimes up to six months. The next reception is acceptable after 3-6 months.

During the first 7-12 days of administration, the dose should be gradually increased, then within 15-40 days the drug should be drunk at the maximum recommended dosage, then for a week daily dose gradually reduce up to complete abolition.

Dosages of syrup depending on the disease:

With long-term treatment with Pantogam syrup, you should not take others at the same time, since it may increase negative effects from each of them.