Instructions for use of tablets and syrup amoxicillin. Structural analogues and their trade names

And many others. Amoxicillin destroys these microbes by attacking their cell walls. However, the drug itself is destroyed in the body under the influence of the enzyme penicillinase (beta-lactamase). Not all bacteria are susceptible to the effects of amoxicillin; there are those who remain insensitive to its influence.

Release form

Amoxicillin is available in the following forms:
1. Capsules 250 mg (16 pieces per pack).
2. Capsules 500 mg (16 pieces per pack).
3. Granules in a vial (for suspension preparation).

All forms of amoxicillin are taken by mouth; the introduction of this antibiotic in the form of injections (shots) is not provided.

Amoxicillin - instructions for use

Indications

Amoxicillin is effectively used in the following cases:

With respiratory tract infections (pharyngitis, sinusitis, tracheitis, laryngitis, bronchitis, pneumonia).
With infections of the upper respiratory tract (tonsillitis, otitis media).
With infections of the urinary tract and genital organs (cystitis, urethritis, pyelonephritis; endometritis, gonorrhea, etc.).
With skin infections (impetigo, erysipelas).
With a number of intestinal infections (dysentery, salmonellosis, typhoid fever and paratyphoid).
With sepsis.
With infections such as listeriosis, leptospirosis, borreliosis.

Contraindications

Allergic diseases (pollinosis, bronchial asthma, allergy to penicillins);
Infectious mononucleosis;
dysbacteriosis;
breastfeeding.

Side effects

1. Allergic reactions (allergic rhinitis, conjunctivitis, urticaria; in rare cases, more severe manifestations of allergies, up to anaphylactic shock).
2. Negative effect on the digestive organs (dysbacteriosis; nausea, vomiting, taste disturbance; stomatitis, glossitis; diarrhea, etc.).
3. Influence on the nervous system (insomnia, agitation, anxiety, depression, headaches, dizziness, convulsions).

Side effects of amoxicillin, especially reactions from the nervous system, are quite rare.

Treatment with amoxicillin

How to take amoxicillin?
Amoxicillin in any form is taken orally. Eating does not affect the absorption of the drug from the gastrointestinal tract, so you can take it both before meals and after, at a time convenient for the patient.

Dosage of amoxicillin
The usual dosage of amoxicillin for adults and children over 12 years of age (weighing over 40 kg) is 500 mg 3 times a day. But in each case, the doctor determines the dose, and if necessary (in case of severe illness), it can be increased to 750-1000 mg 3 times a day, and even more. The maximum allowable daily dose for adults is 6 g.

For some diseases, a non-standard dosage of amoxicillin is used. For example, in acute gonorrhea, men are prescribed 3 g of the drug once; women are given the same dose twice. In typhoid fever, amoxicillin is used in a high dosage: 1.5-2 g 3 times a day. With leptospirosis, high doses of the drug are also used: 500-750 mg 4 times a day.

After the disappearance of external signs of any disease, treatment with amoxicillin continues for another 2-3 days, in order to avoid recurrence of the infection. On average, the course of treatment is from 5 to 12 days.

Instructions for use of amoxicillin for children

Amoxicillin is widely used in the treatment of children of all ages, including newborns and premature babies. In this case, for children under 5 years of age, amoxicillin is used in the form of a suspension.

Suspension of amoxicillin

Suspension of amoxicillin is prepared at home: chilled boiled water is added to the bottle with granules (up to the mark on the bottle), and shaken. A thick liquid mass of yellowish color is formed, with the smell and taste of strawberries or raspberries. The resulting medicine can be stored for 14 days at room temperature. Shake each time before use. One measured (or regular teaspoon) holds 5 ml of suspension; the content of amoxicillin in such an amount of suspension is 250 mg.

Indications

Amoxicillin is usually prescribed for children on an outpatient basis, i.e. in the treatment of mild forms of various diseases, most often in acute respiratory viral infections with bacterial complications, for example:

With acute otitis.
With pharyngitis, tracheitis, bronchitis.
For skin infections (impetigo).
With mild forms of intestinal infections.
Sometimes - for the treatment of gastric ulcer and 12 duodenal ulcer, as well as for the prevention of recurrence of this disease.

Contraindications

Individual intolerance to the drug;
allergic diathesis and other allergic diseases;
intestinal dysbacteriosis;
Infectious mononucleosis ;
lymphocytic leukemia;
severe liver disease.

Caution must be exercised in the treatment of amoxicillin in children with increased bleeding and impaired renal function.

Dosage of amoxicillin for children

Amoxicillin, like any other antibiotic, should only be prescribed to children by a doctor. He also prescribes the dose of the drug, depending on the age and weight of the child, and on the severity of the disease.

The average dosage of amoxicillin for children is as follows:
1. Children under 2 years old - 20 mg / kg body weight / day. This dose is divided into 3 doses.
2. Children 2-5 years old - 125 mg (i.e. 1/2 scoop of suspension) 3 times a day.
3. Children 5-10 years old - 250 mg (1 scoop of suspension) 3 times a day.

For newborns and premature babies, the doctor prescribes amoxicillin strictly individually, in a small dosage, with extended intervals between doses of the drug.

Amoxicillin during pregnancy

Amoxicillin is prescribed to women during pregnancy only if the expected benefit of this drug to the mother outweighs the possibility of harm to the fetus. Although there have been no cases of negative effects of amoxicillin on the course of pregnancy and childbirth, no qualified studies have been conducted on this topic. Therefore, doctors prefer not to take risks.

And during the period of breastfeeding, the mother's amoxicillin is contraindicated: it penetrates into breast milk and can cause allergic reactions in the baby or a violation of the intestinal microflora.

Amoxicillin for angina

With purulent forms of angina (follicular and lacunar), amoxicillin is often prescribed as an effective drug with a small number of side effects. The effectiveness of amoxicillin in angina is due to the fact that this disease is most often caused by staphylococcus, a microbe that is sensitive to the effects of this antibiotic.

Although in other diseases amoxicillin is given to the patient regardless of food intake, in angina this drug should be taken after meals in order to prolong its direct effect on the inflamed tonsils.

Amoxicillin and alcohol

Alcohol is incompatible with taking amoxicillin. The combination of these substances can cause a severe allergic reaction, up to the death of the patient. In addition, both alcohol and amoxicillin have a strong toxic effect on the liver. The work of this organ may be paralyzed. Even after the end of treatment with amoxicillin, it is necessary to refrain from taking alcoholic beverages for 7-10 days.

Amoxicillin + clavulanic acid (Amoxiclav)

There is a drug in which amoxicillin is combined with clavulanic acid. This drug is called amoxicillin clavulanate , or Amoxiclav, or Augmentin. We remember that amoxicillin in the human body is not stable enough due to the action of the penicillinase enzyme. Clavulanic acid has the ability to block this enzyme, so that amoxicillin does not break down and acts on harmful bacteria longer than usual. Amoxiclav is considered to be a stronger drug than amoxicillin.
Indications for the use of Amoxiclav:

Bacterial infections of the lower respiratory tract (pneumonia, bronchitis, lung abscess, pleural empyema).
Infections of the ear, throat and nose (otitis media, tonsillitis, tonsillitis, sinusitis, frontal sinusitis).
Infections of the urinary and genital organs (pyelonephritis, pyelitis, prostatitis, salpingitis, ovarian abscess, endometritis, postpartum sepsis, septic abortion, gonorrhea, soft chancre, etc.).
Infections of the skin and soft tissues (abscess, phlegmon, erysipelas, infected wounds).
Postoperative infections and their prevention.

Amoxiclav release forms:
1. Tablets of 375 mg and 625 mg (the content of amoxicillin is indicated in mg).
2. Powder for the preparation of a suspension with a drug concentration of 156 mg / 5 ml and 312 mg / 5 ml.
3. Powder for inhalation 600 mg per pack, and 1.2 g per pack.

Dosage of Amoxiclav calculated on amoxicillin, since this particular antibiotic is the active ingredient in the preparation.

Analogues

To analogues of amoxicillin, i.e. Drugs containing amoxicillin as the active ingredient include:

Amoxicillin Solutab (manufacturer - Russia, "Norton");
Amoxicillin trihydrate (manufacturer - Russia);
Amoxicillin-Ratiopharm (manufacturer - Germany);
Amoxicillin-Teva (Israel);
Amoxicillin Sandoz (Austria);
Amoxillate (Germany);
Apo-Amoxi (Canada);
Amosin (Russia);
Amoxisar (Russia);
Bactox (France);
Gonoform (Austria);
Grunamox (Germany);
Danemox (India);
Ospamox (Austria);
Thaisil (Bangladesh);
Flemoxin solutab (Netherlands);
Hikoncil (Slovenia);
Ecoball (Russia);
E-Mox (Egypt).

Flemoxin solutab (Netherlands) - these tablets of pleasant taste are well-deservedly popular. They can be taken in a way that is convenient for the patient: swallow, chew, dissolve in water, milk, juice, tea. The flavoring vanilla-apricot additive also has hypoallergenic properties (that is, it reduces the possibility of developing allergic reactions).

Reviews

Almost all the reviews available on the Internet about the antibiotic amoxicillin are positive. Patients note a quick effect of taking the drug, ease of use (reception does not depend on the time of eating), complete recovery from existing diseases at the end of the course of treatment.

A small percentage of negative reviews in which patients complain that the drug "did not help" is due to the fact that amoxicillin, although it is a broad-spectrum antibiotic, is not omnipotent, and not all bacteria are sensitive to its action. Therefore, it is recommended to conduct an examination of the patient before prescribing this antibiotic: isolate the causative agent of the disease and check its sensitivity to the drug. But these studies require a rather long time, and are usually carried out in stationary conditions. In practice, the doctor, seeking to alleviate the patient's condition, prescribes treatment without examination, partly "at random", and sometimes makes mistakes. Patients consider the lack of effect of treatment as a lack of the drug - this opinion is incorrect.

Where to buy amoxicillin?

Amoxicillin, or one of its many analogues, can be bought at almost any pharmacy, but it is released by prescription.

Price

Amoxicillin is not among the expensive drugs. Its price in capsules, depending on the dosage, ranges from 37 to 99 rubles.

The price of granules for the preparation of amoxicillin suspension in different pharmacies ranges from 89 to 143 rubles.

Before use, you should consult with a specialist.

Amoxicillin 250 for children is a powerful antibiotic against various infections. The tool has a minimum of side effects and contraindications, therefore it is widely used. It is important to know that the dosage should be prescribed only by the attending doctor on an individual basis.

Indications for use

Take Amoxicillin 250 mg for children is indicated for such pathologies:

Infectious diseases of the respiratory tract and ENT organs. These in children include: tonsillitis, otitis media, bronchitis, pneumonia, pharyngitis, sinusitis;
Urogenital system. The most common are pyelonephritis, cystitis, urethritis, glomerulonephritis;
Skin and soft tissues;
Gastrointestinal tract - such as cholecystitis, peritonitis, enteritis, cholangitis;
Meningitis;
Leptospirosis;
Sepsis;
Peptic ulcer of the stomach.

Taking the remedy is shown only after visiting the doctor and receiving all the recommendations.

Instructions for use

According to the instructions for use, the dose of Amoxicillin 250 for children is prescribed at the age of 5 to 10 years. Children of this age are not recommended to use the drug at a dose of more than 250 mg per dose. Children can be prescribed the highest dosage, so very often the frequency of use is reduced to once every 24 hours. Amoxicillin 250 for a child of 2 years old is prescribed only in case of severe treatment of an exacerbated disease. The standard dosage for children of this age is 125 mg.

For older children weighing over 40 kg, a single dose of 250 mg is recommended. Only in the case of a complicated course of the disease, the dose is increased to 1 gram. Finding the right dosage is not difficult. Use a suspension containing 125 or 250 mg of the active substance in 5 ml - then a single dose will be 10 or 5 ml, respectively.

A suspension containing 250 mg of Amoxicillin in 5 ml of a ready-made suspension can be the root cause of side effects in children up to a year old. Therefore, the doctor is obliged to prescribe to the baby a suspension with a lower content of the main substance - 125 mg per 5 ml of the finished suspension, or choose another, more gentle drug.

Antibiotic use

In acute diseases of the respiratory tract and in the case of a microbial infection, the drug is most often prescribed in the form of tablets with clavulanic acid. After taking the medicine, the child's condition improves significantly.

If there are ailments of the gastrointestinal tract, then young children are prescribed a suspension of Amoxicillin. It acts more smoothly on the mucous membranes of the stomach. To prepare the suspension, the required amount of boiled water is added to the mark in the vial and stirred well until smooth. Depending on the dosage, it is possible to obtain a dosage of 125 or 250 mg of the active substance in 5 ml of the finished suspension.

According to the instructions, children under two years of age are not recommended to take the tablet form of Amoxicillin at a dose of 250 mg. This form of the drug often causes irritation of the mucous membrane of the digestive tract, it is not always possible for a child to swallow a pill, it is difficult to adjust the dosage. The best option is Amoxicillin suspension, it is produced in the form of granules, which are easily diluted with water.

Contraindications

The drug should not be used by children in case of renal failure. An allergic reaction to the main active ingredient and penicillin derivatives is also a contraindication to taking the drug. In the presence of kidney disease, it is also worth replacing the remedy with another medication. The drug is not prescribed for intestinal dysbacteriosis.

Article verified
Anna Moschovis is a family doctor.

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Amoxicillin ® refers to semi-synthetic penicillins with a bactericidal mechanism of activity. According to statistics, this is the most "purchased" tableted antibiotic. In terms of sales, only azithromycin preparations can compete with it. What is the reason for such popularity of the remedy among doctors and ordinary consumers?

Amoxicillin ® - instructions for use of a 500 mg tablet for adults

How to take amoxicillin ® according to the official instructions? Despite the fact that the bioavailability of the drug does not depend on food intake, in order to reduce the likelihood of developing dyspeptic disorders from the gastrointestinal tract, it is recommended to use Table. before meals or at the beginning of a meal. Tablets must not be chewed, crushed or broken (with the exception of Flemoxin Solutab ®). The antibiotic is washed down with a glass of non-carbonated, boiled water. Do not use juices, milk, tea or carbonated drinks.

Tab. Flemoxin ® can be chewed, dissolved in water to the consistency of syrup (20-30 milliliters of water) or suspension (from 100 milliliters). As in the previous case, only non-carbonated, boiled water is used.

The course of taking the drug is from seven to 14 days.

The duration of treatment is determined by:

the severity of the disease;
speed of positive dynamics;
the sensitivity of the pathogen;
localization of the infectious and inflammatory process;
the presence of background (aggravating) pathologies.

Amoxicillin ® - is it an antibiotic or not?

Amoxicillin ® is an antibacterial agent. Pharmacological group - penicillins with an extended spectrum of antimicrobial activity.

It is an improved modification. Unlike its predecessor, amoxicillin ® is acid-resistant and highly absorbable when taken orally. Its bioavailability is independent of food intake.

The drug is able to be completely absorbed in the intestine in a short period of time and create a high, stable concentration in the blood. However, its concentration in the lower gastrointestinal tract is quite low, so the drug is not prescribed for the treatment of intestinal infections.

As well as ampicillin, it is completely destroyed by bacterial enzymes (beta-lactamases), therefore it is not prescribed for the treatment of infections caused by beta-lactamase-producing strains.

Amoxicillin ® - release form and composition

The active substance is amoxicillin.

Soluble form produced by the Dutch pharmaceutical company Astellas ® has a release form in table. with an antibiotic content of 125, 250, 500 and 1000 milligrams. Price 230, 280, 360, 480 rubles. per pack of 20 tablets respectively.

Additionally contains microcrystalline and dispersible cellulose, flavors and sweeteners.

Amoxicillin ® from the Serbian company Hemofarm ® in the form of granules for oral suspension, dosage of 250 milligrams in five milliliters (100 ml bottle) will cost the Russian buyer 120 rubles.

Additionally, the composition of the drug includes thickeners, sweeteners, flavorings.

Capsules of amoxicillin ® 250 mg and 500 mg contain 250 and 500 milligrams of amoxicillin trihydrate, respectively. Produced by the Serbian company Hemofarm (about 70 rubles per pack of 16 tablets),
Amoxicillin ® 250 and 500 mg tablets contain, respectively, 250 and 500 milligrams of amoxicillin trihydrate.

Packing photo of Amoxicillin ® 500mg tablets from SANDOZ ®

As additional components, the content of potato starch, lactulose, croscarmellose sodium, crospovidone, talc, polysorbate-80 and magnesium stearate is indicated.

Produced by the Russian companies Biochemist Saransk ® and AVVA RUS ® (500 milligrams pack — 70 rubles).

Tablets of 250 milligrams produced by Synthesis AKOMP ® (trade name Amosin ®) will cost the buyer 40 rubles.

Powder for the manufacture of a suspension for oral use (Amosin ® 250 mg in 3 grams. The package contains 10 sachets) and costs about 50 rubles. One sachet contains 250 milligrams of amoxicillin trihydrate.

Amoxicillin ® prescription in Latin (solutab form - Flemoxini Solutabi)

Rep: Tab. Amoxicillini 1.0
D.t.d: No. 20 in tab.
S: 1 tab. 3 r/d

What helps amoxicillin ® ?

The antibacterial action of a bactericidal nature is due to the ability of the antibiotic to disrupt the processes of synthesizing the supporting polymers of the cell membranes of pathogens at the time of their division, leading to the lysis of bacteria.

Amoxicillin ® during pregnancy

Given the ability of the antibiotic to penetrate the placental barrier and accumulate in the tissues of the fetus, amoxicillin ® during pregnancy is prescribed strictly according to indications and after agreement with the attending physician. The expected benefit of treatment for the mother must outweigh the perceived risk to the unborn child.

The admissibility of prescribing Wed-va is due to the lack of data on mutagenic, teratogenic and embryotoxic effects on the fetus. However, controlled and large-scale studies have not been conducted, in connection with this, amoxicillin ® is prescribed during pregnancy, but the drug is classified as an effect on the fetus according to the FDA - B. That is, the absence of a negative effect on the fetus was confirmed by an animal study.

Amoxicillin ® while breastfeeding

The antibiotic in small quantities penetrates and is excreted in breast milk. Therefore, amoxicillin ® during breastfeeding can be prescribed strictly according to the indications and under the supervision of the attending physician. Considering the risk of developing sensitization, dysbacteriosis, diarrhea, and thrush in a child, when it is used during lactation, temporary cancellation of breastfeeding may be recommended.

Dosage of amoxicillin ® for adults

The starting daily dose for patients over ten years old, weighing more than forty kilograms, is 1500 mg (3 tablets of 500), divided into three doses.

For the treatment of severe infections, it is possible to increase the dose to one gram every eight hours.

Patients with uncomplicated gonorrhea (acute course) are recommended to take a single dose of three grams of the antibiotic. Women need to take the drug for two days.

Acute diseases of the gastrointestinal tract of an infectious-inflammatory nature and gynecological infections - from one and a half to 2 grams three times a day or from 1 to 1.5 grams every six hours.

Leptospirosis - 500 to 750 mg every six hours.

Salmonella carriage - from 1.5 to 2 grams, the duration of treatment is from two weeks to a month.

Prevention of endocarditis during surgery - from 3 to 4 grams one hour before surgery. It is possible to take the drug again after eight hours.

With reduced GFR, the dose or time interval between taking the drug is adjusted, depending on the glomerular filtration rate.

Dosage of amoxicillin ® suspension for children

For babies under two years old, the dose is calculated at 20 milligrams per kilogram of body weight, the drug is prescribed three times a day. In severe infections, the dosage can be increased to 60 milligrams per kg.

The neonatal period and prematurity are indications for dose reduction or increase in the interval between taking the drug.

From two to five years, take 125 milligrams every eight hours.

From five to 10 - 0.25 grams, every eight hours.

Children over the age of 10, weighing more than 40 kilograms, are prescribed adult dosages.

How is the suspension diluted?

In a diluted state at room temperature, the suspension can be stored for up to two weeks. Only clean, non-carbonated water can be used as a solvent in its manufacture. Water is added to the suspension powder vial and mixed thoroughly. Shake the resulting mixture before each use. Five milliliters of suspension contains 250 ml of antibiotic.

Amoxicillin ® side effects and effects

Most often, an allergy develops to amoxicillin ® . Of the other undesirable effects, dysbacteriosis and thrush are possible. Sometimes patients complain of a change in taste sensations, nausea and abdominal pain. In rare cases, antibiotic-associated diarrhea and colitis may develop.

Immunocompromised patients may develop superinfection.

From the side of the central nervous system, a feeling of anxiety, insomnia, dizziness, convulsions are possible.

Changes in the analyzes are also possible (increased levels of liver transaminases, a decrease in the number of leukocytes, platelets and neutrophils, anemia rarely develops).

Amoxicillin ® and alcohol compatibility

Despite the fact that penicillins are not included in the list of drugs that lead to a disulfiram-like effect, alcohol in combination with antibiotics can cause liver and central nervous system damage, drug overdose, and also lead to severe intoxication. Therefore, amoxicillin and alcohol are incompatible. At the time of treatment, it is recommended to stop drinking alcohol.

Analogues

Amoxicillin ® can be produced under the trade names:

Of the side effects, the most common are allergy to amoxicillin ® , thrush and dysbacteriosis. The rest are quite rare. Disorders from the gastrointestinal tract can be avoided if you take the remedy according to the instructions, that is, before eating.

Amoxicillin suspension is an inexpensive and well-known antibacterial agent with good reviews. The drug is widely used in their practice by pediatricians. With good performance, it is safe, which is important in the treatment of small patients.

This antibiotic belongs to the penicillin group. It has a fairly wide spectrum of action. With its use, it is possible to suppress the activity of harmful bacteria, for example, staphylococci, streptococci, E. coli, and so on. Amoxicillin is able to destroy microorganisms by acting on the cell walls. But not all of them will be sensitive to the effects of the drug.

Characteristics of the drug Amoxicillin

Both adults and children use this antibiotic for a long time, which allowed him to fully demonstrate his action. Amoxicillin is classified as a first-line drug. Many bacteria have already appeared that are resistant to its action. This fact is associated with beta-lactamase, an enzyme that can block the action of an antibiotic drug.

Amoxicillin is available in the following forms: tablets of 250 and 500 mg; Amoxicillin suspension for children has also been developed, for the preparation of which granules of 125 mg / 5 ml, 250 mg / 5 ml are made.

Being an antibiotic of the penicillin series, the drug is particularly active against pathogens of the following diseases:

Angina and bronchitis;
Pharyngitis of bacterial origin;
Sinusitis and sinusitis, inflammation of the upper respiratory tract;
Pneumonia is not specific;
Infectious diseases of the kidneys;
Endocarditis;
Infections of the skin, soft tissues.

The action of the drug is based on the delay in the synthesis of the structure of the cell wall of microorganisms.

When is an antibiotic indicated?

Amoxicillin is an active chemical that is found in many drugs with a similar effect. Among them is a medicine of the same name for the preparation of a suspension, that is, amoxicillin.

The most common reason for visiting a pediatrician is an acute respiratory infection. If the disease is manifested by a runny nose, cough and sore throat, this situation does not always require treatment with an antibiotic drug. Even at high temperatures, such symptoms are caused by viruses, and only non-specific treatment is required - it consists in bed rest, taking antipyretics and drinking plenty of water. But many cases of the disease require treatment with antibiotics.

The drug Amoxicillin in the form of a suspension has a low price and is suitable for any wallet. It is prescribed for such manifestations:

With manifestations of purulent, bacterial, lacunar tonsillitis.
If the doctor hears coarse or fine bubbling rales in the lungs.
If pneumonia is suspected - intoxication, fever, pain in the chest, with weakening of breathing in the lungs. With such manifestations, children are often referred for inpatient treatment.
With deterioration, viral infections, bacterial inflammations and fevers. Symptoms of poisoning can last up to three days.

Why is Amoxicillin Suspension prescribed?

Amoxicillin suspension 250 mg is a convenient form of release, which is usually prescribed to pediatric patients. Instructions for use suspension Amoxicillin allows you to take it from the age of three months. If the child is younger than this age, the reception is carried out under the supervision of a doctor and only if necessary. The dose for admission is calculated individually, depending on the weight of the baby.

Suspension preparation

Five- and ten-year-old children are prescribed the drug both in the form of a suspension and tablets with a dosage of 250 mg. Children over 10 years of age are more likely to receive 500 mg tablets.

Suspension is prepared by mixing the granules with boiled cold water and stirring until completely dissolved. Shake the vial before taking the suspension again.

Amoxicillin suspension 250 mg is taken with or without food. Diluted medicine can be stored no more than 14 days. Reception of Amoxicillin in suspension of 250 mg is carried out according to the instructions for use.

The composition of the drug and the effect on the body

Amoxicillin suspension 250 mg price is not particularly high and is suitable for complex treatment. As part of the drug, the active substance is amoxicillin trihydrate. The component is contained in the drug in a dosage that is selected in accordance with the release form. Auxiliary additives are also used to compile the drug - they give the drug other necessary properties, they can affect the shelf life of the drug in the direction of increase.

In addition to a special form of trihydrate, the composition of the drug includes:

lactose monohydrate;
calcium stearate;
magnesium stearate;
Polysorbate;
Potato starch and talc.

When taking the medication, its properties are noted:

Accelerated absorption of the drug;
Rapid penetration into tissues and organs;
The half-life is one and a half hours;
The kidneys excrete the substance unchanged.

Contraindications to the use of the drug

Amoxicillin suspension for children reviews on the application can be found different. Negative ones are mostly associated with a violation of the rules for using the drug. According to the instructions, it is not allowed to use the drug with clavulanic acid for the treatment of liver disease or jaundice. The drug Amoxiclav contains, in addition to Amoxicillin, clavulanic acid. In the human body, amoxicillin is not particularly resistant, the reason for this is the enzyme penicillanase. One of the properties of clavulonic acid is the blocking of this enzyme. As a result of such assistance, the destruction of the active substance does not occur, it is able to act on harmful microorganisms for a longer time.

You can not be treated with a medication called Amoxicillin with such diagnoses:

Allergic diathesis;
lymphocytic leukemia;
Infectious mononucleosis;
Asthma is bronchial.

Amoxicillin as a bactericidal drug has contraindications - it is forbidden to use it for treatment in such cases:

Allergies to the components of the drug;
Violations of the hematopoietic system;
Hypersensitivity to the components of the drug;
Colitis, hay fever;
bleeding;
Problems with the nervous system.

Side effects of the drug

Amoxicillin has a number of side effects. Before taking any drug, this paragraph of the instruction should be studied especially carefully:

Allergies, the manifestation of which is urticaria, pruritus, Quincke's edema, which may be accompanied by anaphylactic shock;
Erosion of mucous membranes, stomatitis;
Nausea, vomiting;
Sleep disturbances, headaches;
Tachycardia;
Pain in the joints;
Dysbacteriosis, anemia.

To prevent the development of complications of a dysbiotic nature from the intestines, expressed as flatulence, pain and pain in the abdomen, stench of stools or diarrhea, children are prescribed probiotic medications along with antibacterial drugs. Such means include normobact, Linex, Enterogermina and so on. Preventive treatment takes approximately 10-14 days.

Therapy with the use of Amoxicillin includes proper, regular nutrition, walks in the fresh air.

Drug analogues

For patients who need treatment, the effect of which is achieved using amoxicillin, but cannot take the medication due to poor tolerance of the components, the use of similar agents is allowed. Analogue drugs in the form of a suspension have an identical effect, their side effects are similar. Can be used to treat Amosin and Ospamox, Amoxicillin-ratiopharm. They all have about the same cost. With the usual uncomplicated form of the disease, after a couple of days the child begins to recover.

Amosin Ospamox Amoxicillin-ratiopharm

Amoxicillin suspension is dispensed by prescription, which the doctor can write out in Latin. In the treatment of infectious diseases in young children, the advantages of the drug are great enough to give preference to it over others.

The composition of the drug is selected in such a way that the likelihood of side effects is extremely low. This creates relative safety during treatment - most young patients tolerate this antibiotic calmly. It can even be used to treat very young children and infants. The cost of Amoxicillin is low, and the ease of use and pleasant taste for the child provide additional advantages in the treatment of the drug.

It can be concluded that Amoxicillin is a well-proven medication, with which it is possible to quickly cure an inflammatory disease. Questions regarding the choice of antibiotic drug for treatment, in any case, should be decided by the pediatrician.

Amoxicillin in suspension, reviews

Most of the reviews about the drug that are available on the Internet and in other sources are positive. In almost every case, there is an excellent effectiveness of the drug, fast action. It is convenient to use it, since assimilation does not depend on the intake of food and the techniques do not need to be tied to a specific regimen. At the end of the treatment course, it is possible to fully recover, the disease goes away without a trace.

There is also a small part of the negative reviews on Amoxicillin in suspension 125 mg, the price of which differs downward from other drugs of similar action. Most often they are associated with the fact that a drug containing amoxicillin is not able to cope with absolutely all diseases of an infectious nature. Not all bacteria are susceptible to its action. Before prescribing a drug containing an antibiotic, it is recommended to conduct a thorough examination of the patient.

During the examination, the causative agent of the disease is isolated and its sensitivity to the action of the drug is checked. Studies take some time, for their conduct, the patient must be kept in a hospital. Randomly making such appointments is not recommended. Meanwhile, patients receiving treatment with the drug and not noting the promised effect, consider this a drawback of the drug, while under other conditions it works fine.

Amoxicillin (amoxicillin)

Composition and form of release of the drug

10 pieces. - cellular contour packings (2) - packs of cardboard.
20 pcs. - polymer cans (1) - packs of cardboard.
20 pcs. - jars of dark glass (1) - packs of cardboard.
20 pcs. - polymer bottles (1) - cardboard packs.
1 kg - plastic bags (1) - polymer cans.
1 kg - plastic bags (1) - cardboard drums.
10 kg - plastic bags (1) - polymer cans.
10 kg - plastic bags (1) - cardboard drums.
15 kg - plastic bags (1) - polymer cans.
15 kg - plastic bags (1) - cardboard drums.
5 kg - plastic bags (1) - polymer cans.
5 kg - plastic bags (1) - cardboard drums.

pharmachologic effect

An antibiotic of the group of semi-synthetic penicillins with a wide spectrum of action. It is a 4-hydroxy analogue. It has a bactericidal effect. Active against aerobic gram-positive bacteria: Staphylococcus spp. (with the exception of penicillinase-producing strains), Streptococcus spp.; aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp.

Microorganisms producing penicillinase are resistant to amoxicillin.

In combination with it is active against Helicobacter pylori. Amoxicillin is believed to inhibit the development of Helicobacter pylori resistance to metronidazole.

Cross-resistance exists between amoxicillin and ampicillin.

The spectrum of antibacterial action is expanded with the simultaneous use of amoxicillin and the beta-lactamase inhibitor clavulanic acid. This combination increases the activity of amoxicillin against Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. However, Pseudomonas aeruginosa, Serratia marcescens and many other Gram-negative bacteria remain resistant.

Pharmacokinetics

When taken orally, amoxicillin is rapidly and completely absorbed from the gastrointestinal tract, is not destroyed in the acidic environment of the stomach. Cmax of amoxicillin in the blood is reached after 1-2 hours. With a 2-fold increase in the dose, the concentration also increases by 2 times. In the presence of food in the stomach does not reduce overall absorption. With intravenous, intramuscular administration and ingestion, similar concentrations of amoxicillin are achieved in the blood.

The binding of amoxicillin to plasma proteins is about 20%.

Widely distributed in tissues and body fluids. High concentrations of amoxicillin in the liver have been reported.

T 1 / 2 from plasma is 1-1.5 hours. About 60% of the dose taken orally is excreted unchanged in the urine by glomerular filtration and tubular secretion; at a dose of 250 mg, the concentration of amoxicillin in the urine is more than 300 mcg / ml. A certain amount of amoxicillin is determined in the feces.

In newborns and the elderly, T 1/2 may be longer.

With renal failure, T 1/2 can be 7-20 hours.

In small amounts, amoxicillin penetrates the BBB during inflammation of the pia mater.

Amoxicillin is removed by hemodialysis.

Indications

For use as monotherapy and in combination with clavulanic acid: infectious and inflammatory diseases caused by susceptible microorganisms, incl. bronchitis, pneumonia, tonsillitis, pyelonephritis, urethritis, gastrointestinal infections, gynecological infections, infectious diseases of the skin and soft tissues, listeriosis, leptospirosis, gonorrhea.

For use in combination with metronidazole: chronic gastritis in the acute phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Contraindications

Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and / or cephalosporins.

For use in combination with metronidazole: diseases of the nervous system; hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives.

For use in combination with clavulanic acid: a history of liver dysfunction and jaundice associated with taking amoxicillin in combination with clavulanic acid.

Dosage

Individual. For oral administration, a single dose for adults and children over 10 years old (weighing more than 40 kg) is 250-500 mg, with severe disease - up to 1 g. For children aged 5-10 years, a single dose is 250 mg; at the age of 2 to 5 years - 125 mg; for children under the age of 2 years, the daily dose is 20 mg / kg. For adults and children, the interval between doses is 8 hours. In the treatment of acute uncomplicated gonorrhea, 3 g once (in combination with probenecid). In patients with impaired renal function with CC 10-40 ml / min, the interval between doses should be increased to 12 hours; with CC less than 10 ml / min, the interval between doses should be 24 hours.

For parenteral use in adults, intramuscularly - 1 g 2 times / day, intravenously (with normal kidney function) - 2-12 g / day. Children in / m - 50 mg / kg / day, a single dose - 500 mg, the frequency of administration - 2 times / day; in / in - 100-200 mg / kg / day. In patients with impaired renal function, the dose and interval between injections must be adjusted in accordance with the values of CC.

Side effects

Allergic reactions: urticaria, erythema, angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia; in isolated cases - anaphylactic shock.

Effects associated with chemotherapeutic action: development of superinfections is possible (especially in patients with chronic diseases or reduced body resistance).

With prolonged use in high doses: dizziness, ataxia, confusion, depression, peripheral neuropathy, convulsions.

Mainly when used in combination with metronidazole: nausea, vomiting, anorexia, diarrhea, constipation, epigastric pain, glossitis, stomatitis; rarely - hepatitis, pseudomembranous colitis, allergic reactions (urticaria, angioedema), interstitial nephritis, hematopoiesis disorders.

Mainly when used in combination with clavulanic acid: cholestatic jaundice, hepatitis; rarely - erythema multiforme, toxic epidermal necrolysis, exfoliative dermatitis.

drug interaction

Amoxicillin may reduce the effectiveness of oral contraceptives.

With the simultaneous use of amoxicillin with bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, rifampicin), synergism is manifested; with bacteriostatic antibiotics (including macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin enhances the effect of indirect anticoagulants by suppressing the intestinal microflora, reduces the synthesis of K and the prothrombin index.

Amoxicillin reduces the effect of drugs, during the metabolism of which PABA is formed.

Probenecid, diuretics, allopurinol, phenylbutazone, NSAIDs reduce the tubular secretion of amoxicillin, which may be accompanied by an increase in its concentration in blood plasma.

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce, and increase the absorption of amoxicillin.

With the combined use of amoxicillin and clavulanic acid, the pharmacokinetics of both components does not change.

special instructions

Use with caution in patients prone to allergic reactions.

Amoxicillin in combination with metronidazole is not recommended for use in patients under 18 years of age; should not be used in liver disease.

Against the background of combination therapy with metronidazole, it is not recommended to drink alcohol.

For impaired renal function

In patients with impaired renal function, the dose and interval between injections must be adjusted in accordance with the values of CC.

For impaired liver function

Amoxicillin in combination with metronidazole should not be used in liver disease.