Is there an analogue of duphaston. Important points of therapy

Most patients need long-term use medicines, sometimes it is not possible to buy a drug in enough for passing full course which forces them to seek cheap analogues Duphaston. But are there any? And if so, how do they correspond to the prescribed remedy?

Duphaston (Duphaston)- common in gynecological practice a drug containing a synthetic analogue of progesterone (a hormone responsible for normal course pregnancy) and used for:

endometriosis;
disorders menstrual cycle(dysmenorrhea, secondary amenorrhea);
infertility resulting from luteal insufficiency;
uterine bleeding;
menopause or similar disorders of the female reproductive system as a remedy replacement therapy;
premenstrual syndrome.

Now we will try to answer these and some other questions, and at the same time find a worthy replacement that meets all necessary requirements and providing therapeutic results that are indistinguishable from the original.

Criterias of choice

Analogues of the drug Duphaston should not only differ from it in price (downwards), but also have the same spectrum therapeutic activity(treat for the same or most of the diseases indicated in the instructions for its use). However, they may not be absolutely identical and may not contain a similar active ingredient. Therefore, when reviewing medicines, we will divide them into two conditional groups.

Necessary warning: all of the "Duphaston substitutes" listed below, despite the fact that data from reliable sources were used in their search, in no case replace the recommendations of the attending physician and do not cancel his appointments. And therefore, if it is necessary to change the drug to one of those provided in this article (except for the cases specified), we strongly recommend that you notify the specialist and undergo additional consultation in order to prevent the occurrence of possible complications.

Identical preparations

Full analogues of Duphaston are:

Dufaston;
Dydrogesterone.

Both drugs differ from the original only in name and contain the same active ingredient - dydrogesterone, which means that their action, indications and contraindications are completely identical. These drugs are what can replace Duphaston, without any health hazard. But even despite these qualities, each of them has its own characteristics that are important for potential buyers.

Dufaston: most likely this drug was just released a little later than the other pharmaceutical company. The only possible difference from the fixed asset is in the price, which can be either lower or higher (depending on the place of sale). Possible differences: slight difference in additional components.

Dydrogesterone: the active component of the fixed asset in pure form. The most complete and reliable analogue of tablets, and its price is several times lower than that of Duphaston. However, do not rush to rejoice: it is so rare in pharmacies that it is almost impossible to find it. This is especially true for small towns in remote regions. As for additional components, then their list is minimal and, most likely, they serve only to form a dosage form.

Means with a similar effect

This group includes preparations containing active ingredients similar to progesterone. All of them can be used to treat diseases listed in the indications for Duphaston.

Utrozhestan(Utrogestan) is an analogue of Duphaston from Thailand, which contains natural micronized progesterone obtained from volunteers or animals as an active ingredient. Hence, more high efficiency and a relatively low probability of the possibility of allergic reactions (hormones do not contain an antigenic structure and work equally well in various kinds animals). But at the same time, the drug is contraindicated in case of bleeding from birth canal women of unknown origin and can cause drowsiness, which is why it is contraindicated for those who are busy active species activities or driving Vehicle.

Progesterone(progesterone)- Russian analogue Duphaston, containing in the composition of the gestagen - the hormone of the corpus luteum. Despite the obvious difference in the active ingredient, it is used in the same cases as the main drug. A significant difference is that the latter is produced exclusively in dosage form for injection, which makes it somewhat difficult independent application which allows it to be used in the hospital. But on the other hand, it leads to the achievement of a therapeutic effect much faster than tablet forms and, as a result, can become the drug of choice for especially severe forms of spontaneous abortion.

What we have

Small list available analogues, which may still provide some choice for buyers:

Dufaston;
Dydrogesterone;
Utrozhestan;
Progesterone.

In fact, no matter what analogue of Dufaston a woman takes during pregnancy, if its further course depends on the drug, only the fact that the price of the analogue of Duphaston is cheaper than the original by several points becomes important. Because of this alone, most average patients will be able to afford long-term therapy and raise a new full-fledged member of our society.

In this article, you can read the instructions for using the drug Duphaston. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of medical specialists on the use of Duphaston in their practice. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Duphaston analogues, if available structural analogues. Use for the treatment of endometriosis, infertility in women, as well as during pregnancy, its planning and breastfeeding.

Duphaston- analogue of natural progesterone. Duphaston in its own way molecular structure, chemical and pharmacological properties very close to natural progesterone. Due to the fact that dydrogesterone is not a testosterone derivative, it does not have the side effects of most synthetic progestogens, the so-called androgenic progestogens.

Dydrogesterone does not have estrogenic, androgenic, anabolic, glucocorticoid and thermogenic activity. Does not render negative influence on carbohydrate metabolism and liver function.

Dydrogesterone at oral administration selectively affects the endometrium, thereby preventing increased risk development of endometrial hyperplasia and / or carcinogenesis in conditions of excess estrogens. It is indicated in all cases of endogenous progesterone deficiency.

The drug has no contraceptive action.

When treated with dydrogesterone therapeutic effect achieved without ovulation suppression or menstrual dysfunction. Dydrogesterone does possible conception and maintenance of pregnancy during treatment.

Pharmacokinetics

After oral administration, Duphaston is rapidly absorbed from the gastrointestinal tract. Dydrogesterone is metabolized in the liver. Excreted in the urine from 56 to 79%.

Indications

endometriosis;
infertility due to luteal insufficiency;
threatening or habitual miscarriage (with progesterone deficiency);
premenstrual tension syndrome;
dysmenorrhea, irregular menstrual cycle;
secondary amenorrhea (in complex therapy with estrogen)
dysfunctional uterine bleeding;
to neutralize the proliferative effect of estrogens on the endometrium as part of the replacement hormone therapy in women with disorders due to natural or surgical menopause with an intact uterus.

Release form

Tablets of 10 mg.

Instructions for use and dosing regimen

The drug is taken orally.

With endometriosis, 10 mg is prescribed 2-3 times a day from the 5th to the 25th day of the cycle or continuously.

With infertility (due to luteal insufficiency) - 10 mg per day from the 14th to the 25th day of the cycle. Treatment should be carried out continuously for at least 6 consecutive cycles. Treatment is recommended to continue in the first months of pregnancy as recommended for habitual abortion.

With a threatened miscarriage, 40 mg is prescribed once, then 10 mg every 8 hours until the symptoms disappear.

With a habitual miscarriage, the drug is prescribed 10 mg 2 times before the 20th week of pregnancy, followed by gradual decline doses.

With premenstrual tension syndrome - 10 mg 2 times from the 11th to the 25th day of the cycle.

With dysmenorrhea - 10 mg 2 times a day from the 5th to the 25th day of the cycle.

With an irregular menstrual cycle - 10 mg 2 times a day from the 11th to the 25th day of the menstrual cycle.

With amenorrhea, estrogens are prescribed 1 time per day from the 1st to the 25th day of the cycle, together with Duphaston - 10 mg 2 times from the 11th to the 25th day of the cycle.

To stop dysfunctional uterine bleeding, Dufaston is prescribed 10 mg 2 times a day for 5-7 days.

To prevent dysfunctional uterine bleeding, Duphaston is prescribed 10 mg 2 times a day from the 11th to the 25th day of the cycle.

With hormone replacement therapy in combination with continuous estrogen therapy, Duphaston is prescribed 10 mg 1 time per day for 14 days within a 28-day cycle. With a cyclic estrogen regimen, Duphaston is prescribed at a dose of 10 mg 1 time per day for the last 12-14 days of estrogen intake.

If a biopsy or ultrasound procedure testify to inadequate response on a progestogen drug, the daily dose should be increased to 20 mg.

Side effect

headache, migraine;
breakthrough uterine bleeding (which can be prevented by increasing the dose);
possible hypersensitivity mammary glands;
minor liver dysfunction, sometimes accompanied by weakness or malaise, jaundice or pain in the abdomen;
hemolytic anemia;
skin rash, itching;
urticaria, angioedema;
peripheral edema.

Contraindications

hypersensitivity to the components of the drug.

With caution, the drug should be prescribed with instructions in the anamnesis for pruritus during a previous pregnancy.

Use during pregnancy and lactation

It is possible to use Duphaston during pregnancy according to indications.

Dydrogesterone is secreted from breast milk. Breast-feeding while taking the drug is not recommended.

special instructions

In the case of prescribing dydrogesterone in combination with estrogens (for example, for hormone replacement therapy), contraindications and warnings associated with the use of estrogens should be taken into account.

Before starting hormone replacement therapy (HRT), a complete history should be taken. During treatment, it is recommended to periodically monitor individual tolerance HRT. The patient should be informed about any changes in the mammary glands she should report to the doctor. Investigations involving mammography should be performed in accordance with conventional patient screening.

Sometimes during the first months of treatment, breakthrough uterine bleeding may occur. If a breakthrough bleeding occur after a certain period of taking the drug or continue after a course of treatment, you should study the cause, make an endometrial biopsy in order to exclude malignant changes in the endometrium.

Careful clinical examination when indicating a history of a progesterone-dependent tumor (for example, meningioma), as well as in case of its progression during pregnancy or during previous hormone therapy.

Currently, there are no data on the negative effect of dydrogesterone in chronic renal failure.

Do not prescribe Duphaston tablets to patients with genetically determined galactose intolerance, lactase deficiency or malabsorption syndrome.

Influence on the ability to drive vehicles and control mechanisms

The drug does not affect the ability to drive vehicles and control mechanisms.

drug interaction

At simultaneous application with Duphaston, inducers of microsomal liver enzymes (such as phenobarbital, rifampicin) can accelerate the metabolism of dydrogesterone and reduce the effectiveness of the drug.

Cases of incompatibility with other drugs are unknown.

Analogues of the drug Duphaston

Structural analogues for the active substance:

Iprozhin;
Crinon;
Prajisan;
Progesterone;
Progestogel;
Utrozhestan.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Duphaston - hormonal drug which came out on pharmaceutical market in 1961. It was released by the Solvay company (Netherlands). It was the first oral progestogen. The main feature of this medication is that it promotes metabolic stability. female body without causing changes in estrogenic, androgenic and mineralocorticoid metabolism. Duphaston practically does not cause side effects and is well tolerated by patients. Its main area of application is obstetrics and gynecology. Also, the tool is used in auxiliary reproductive technologies.

The drug does not inhibit ovulation and, therefore, the ability to fertilize in women taking it does not change. The active ingredients selectively affect the endometrium, vaginal mucosa and cervical canal.

Dufaston is indispensable in the treatment of miscarriage, dysfunctional uterine bleeding, endometriosis, infertility and in assisted reproductive technologies (IVF). Duphaston has both expensive and cheap analogues. You can replace it with one of them, but before that, it is imperative to consult a doctor.

Duphaston is today considered one of the most expensive progesterone preparations. Some patients, considering high price on it, they turn to the doctor with a request to replace it with cheap analogues. AT pharmacy network the following substitutes for Duphaston are presented:

Injesta.
Iprozhin.
Oxyprogesterone capronate.
Prajisan.
Progesterone.
Utrozhestan.

All of these products are available for oral and vaginal application. Detailed dosage, form of release and quantity in the package are presented in the table. The price of these medicines (drugs) in Russian pharmacies is slightly different.

injesta

The drug belongs to the pharmacotherapeutic group of gestagens. The main active ingredient is progesterone, which is a hormone corpus luteum. Injesta favorably affects the process of implantation of a fertilized egg and supports normal development embryo in the first half of pregnancy. This is due to the fact that it transforms the proliferation phase of the endometrium during the secretory phase, which is necessary for the physiological reproductive function. reducing excitability and contractility myometrium, it stops and prevents the process of abortion.

Indications are the following conditions:

amenorrhea;
uterine bleeding;
infertility associated with a violation in the endocrine system;
miscarriage;
menstrual irregularities varying degrees severity (for example, algomenorrhea).

The drug can be administered in two ways: intramuscular or subcutaneous. Dosage and duration of use is determined by the indications. To prevent the threat of abortion (if there is low scores progesterone in the blood) or treatment of a threatened abortion that has already begun, use 15-25 mg of Injesta daily until the symptoms disappear completely. If, in connection with the anamnestic data, a diagnosis of "recurrent miscarriage" is made, then the drug should be administered every other day until the fourth month of pregnancy.

With irregular uterine bleeding, 10 mg is administered daily for 7 days. If curettage was performed before the diagnosis, then Injesta can only be used 2 weeks after the procedure. If there is a need for immediate use of the drug, then 15 mg is administered for 6 days.

The drug is not used in pediatric practice and in patients with severe cardiovascular pathology, including arterial hypertension, and at pregnancy in term more than 36 weeks.

Iprozhin

The basis of the drug is micronized progesterone, which has the ability to interact with the surface receptors of the uterus, penetrates into their nucleus, where it activates the organ's DNA and stimulates its RNA. Through these processes, the uterine mucosa passes from proliferative phase into the secretory, thus creating favorable conditions for implantation gestational sac in the uterine cavity. The drug has a relaxing effect on the muscle fibers of the myometrium and fallopian tubes preventing abortion. In addition, Iprozhin induces lactation.

The medication can be used both orally and intravaginally, by injecting deeply into posterior fornix vagina. In the first case of application, the active ingredients reach their peak 2-3 hours after ingestion, in the second - after an hour. The frequency of admission - twice a day during the first trimester of pregnancy. The dosage (100 or 200 mg) can only be determined by a gynecologist, since it all depends on the laboratory parameters of the level of progesterone in the blood of each individual patient.

The drug is indicated for such pathologies:

hormone replacement therapy in case of non-functioning ovaries or their complete absence;
preparation for in vitro fertilization in order to maintain the luteal phase;
prevention and treatment of miscarriage;
infertility;
endometriosis of the uterus;
prevention of tumor neoplasms of the uterus.

It is forbidden to use Iprozhin in the presence of:

allergies to Iprozhin components;
uterine bleeding of unspecified origin;
delays of parts of the embryo in the uterine cavity;
malignant tumors of the uterus, ovaries or breast;
severe heart disease;
hepatic/renal failure.

A feature of the use of Iprozhin is that it can cause disturbances in the liver. In this regard, it is necessary to periodically monitor the activity of liver enzymes.

Oxyprogesterone capronate

The active basis of the drug is active ingredient hydroprogesterone capronate. The composition also includes olive oil refined benzyl benzoate. The drug belongs to the group of hormones of the gonads and drugs used in the pathology of the genital area. Produced by PAT "Biopharma" (Ukraine).

Active substance medication according to chemical structure is a synthetic analogue of human progesterone. Its mechanism of action is similar to natural progesterone: it improves proliferative properties endometrium of the uterus, reduces its excitability, stimulates the preparation of the mammary gland for lactation. It is more stable in the body, so its effect persists for a long time.

Oxyprogesterone is administered intramuscularly, slowly, in the presence of such disorders:

deviations associated with insufficient work of the corpus luteum;
threatened abortion;
primary or secondary amenorrhea;
intermenstrual uterine bleeding;
hyperplastic processes in the endometrium of the uterus, including endometriosis.

You can not use the medication for treatment in such cases:

there is an allergy to the components of oxyprogesterone capronate;
gestational age more than 24 weeks;
pregnancy does not develop;
a history of cholestatic jaundice or renal failure;
the presence of malignant neoplasms of the genital organs is suspected;
severe thrombophlebitis or thromboembolism pulmonary artery in history.

Before use, the ampoule with the drug must be warmed to room temperature. In threatened abortion, the dose of administration is 250 mg once a week. If hypertrophic processes in the uterus are being treated, then in this case only 2 ml of a 12.5% solution is used from the 5th to the 25th day of the menstrual cycle. Do not mix the drug with others in the same syringe.

Prajisan

In each of the forms of release of the drug active ingredient progesterone appears. It has the ability to interact with the surface receptors of the uterus, penetrates into their nucleus, where it activates the DNA of the organ and stimulates its RNA. Thanks to these processes, the uterine mucosa passes from the proliferative phase to the secretory one, thus creating favorable conditions for the implantation of the fetal egg in the uterine cavity. It has a calming effect on the muscle fibers of the myometrium and fallopian tubes, preventing abortion. Produced by an Indian pharmaceutical company.

Pharmacokinetic properties are no different from previous drugs. It selectively accumulates in the uterine cavity, from where it is slowly absorbed into circulatory system, where it reaches its peak an hour after ingestion. Metabolized in the liver and excreted in the urine. It is used for any deviations associated with a violation of the course of the luteal phase, namely:

HRT with dysfunction or absence of the ovaries;
during preparation for IVF in order to normalize the course of the luteal phase;
prevention and treatment of miscarriage;
infertility of endocrine etiology;
endometriosis;
prevention of tumor neoplasms of the uterus;
egg donation program.

Assignment restrictions are the following states:

coagulopathy varying degrees gravity;
bleeding from the genital tract of unknown origin;
porphyria;
retention of parts of the embryo after an abortion;
allergic reaction to the drug.

Both capsules and gel are injected deep into the posterior fornix of the vagina twice a day ( daily dose can range from 200 to 400 mg) with the threat of miscarriage. For infertility therapy, one applicator of Prajisan gel is used and administered daily from the day of ovulation or from the 17th to the 20th day of the cycle for a week. For hygienic reasons, the applicator in the medicinal product is disposable and must be disposed of after use.

Progesterone

Refers to the hormones of the gonads (gestagens) produced by the corpus luteum of the ovaries. By analogy, its basis is progesterone. The drug is injectable. Produced in Russia and Ukraine. This hormonal agent favorably affects the process of implantation of a fertilized egg and supports the normal development of the fetal egg until the 12th week of gestation. This is due to the fact that it transforms the proliferation phase of the endometrium during the secretory phase, which is essential for physiological reproductive function. By reducing the excitability and contractility of the myometrium, it stops and prevents the process of abortion.

The drug is administered intramuscularly or subcutaneously. Before the injection, given that it will inject oil solution, the ampoule must be heated in a water bath to a temperature of 30 degrees. If the solution begins to crystallize, then heating should be continued until the precipitate is completely dissolved.

For bleeding, use 15 mg daily for a week. If curettage was performed before the diagnosis, then Progesterone can be used only 3 weeks after the procedure. If there is a need for immediate use of the drug, then 15 mg is administered for 6 days.

With an overdose of the drug, there are unwanted effects in the form of nausea, vomiting, dizziness, shortness of breath, blurred vision, sweating, feeling hot, etc. At slightest symptoms you should inform the doctor who will replace the drug with a similar one or cancel it altogether.

Main indications for use:

amenorrhea;
intermenstrual bleeding;
infertility associated with the endocrine system;
miscarriage;
menstrual disorders of varying severity (oligomenorrhea, algomenorrhea).

Utrozhestan

Utrozhestan is the most commonly used analogue of Duphaston, which is also several times cheaper than it. Structural formula this medication based on the properties of micronized progesterone, which normalizes the secretory function of the endometrium in women reproductive age and promotes regeneration processes inner surface uterus after surgical interventions(scraping). It also prevents the progression of endometriosis, has a calming effect on the myometrium.

It is especially important that Utrozhestan does not androgenic activity. In numerous clinical trials, its ability to influence the release of luteinizing and follicle-stimulating hormones by the hypothalamus has been proven. In practice, Utrozhestan shows good performance normalization of plasma progesterone levels. It is provided for all of the above obstetric and gynecological conditions associated with insufficiency of the luteal phase of the cycle.

It can be used both vaginally and orally necessary quantity water. Take, depending on the dosage prescribed by the doctor, twice a day until the term of full-term pregnancy. In other cases, the frequency and time of admission should be adjusted by the obstetrician-gynecologist, depending on the woman's menstrual cycle.

On the modern pharmacological market there are many various medicines. Some of them are interchangeable, there are analogues and generics. When it comes to such a drug as Duphaston, then there are several analogues here. It is only important to understand the basic principles of action of each drug and understand the difference.

Duphaston and its analogues

All analogues of Duphaston, like the original drug itself, contain synthetic progesterone, a hormone that is responsible for the course of pregnancy.

They are used when following states observed in women:

menstrual irregularities;
bleeding in the uterus;
acute PMS;
infertility, which is observed due to luteal insufficiency;
endometriosis;
menopause and climacteric syndrome;
mastopathy of the mammary glands.

It is also often prescribed to pregnant women who have threatened abortion. Progesterone contributes to the normal course of pregnancy.

It creates conditions for the normal formation of the fetal egg, secure attachment to the uterine wall, its nutrition, and also prevents miscarriages during the first trimester, when the hormonal background is still unstable. With a lack of progesterone, the body cannot properly respond to the appearance of the fetus, perceives it as a foreign object and rejects it. It is for this reason that frequent miscarriages occur during the first three months of pregnancy.

Duphaston and its analogues are as close as possible in their structure to hormones that naturally are produced by the female body, as a result of which progesterone is most effectively absorbed when internal reception drug. The most important advantage of such funds is their origin. Unlike most synthetic hormones, the substances contained in the preparation are not derived from testosterone, which eliminates the occurrence of many side effects:

disruption of the liver;
blood clotting disorder;
manifestation female signs in a male fetus;
manifestation male signs in female fetuses;
change in glucose concentration;
negative impact on the organs of internal secretion.

Duphaston has practically no contraindications. The only reason a drug can be excluded is individual intolerance some components, that is, allergies. In order to determine whether this remedy is suitable for treatment or not, it is necessary to pass mandatory inspection and consult with an experienced specialist. It has successfully established itself in modern gynecology and is widely used for the treatment and prevention of many conditions.

Choosing the Right Tool

Duphaston is an expensive drug that must be taken for long period time. Often, such expenses can become unbearable for future parents. However, pharmacology offers many replacement options, since there are drugs on the market with similar composition or pharmacological action. So what can replace Duphaston and what criteria should be followed when choosing?

by the most important indicator when choosing an analogue, it is not the price (although it plays a big role), but therapeutic effect funds. Indications for use, a list of conditions in which the medicine is used should match as much as possible. The funds do not have to be completely identical when it comes to composition. Some drugs may have the same active substance, similar to it, or completely differ in composition, but have an almost identical effect on the body. Therefore, all analogues can be divided into two main groups:

identical;
drugs with a similar effect.

It is very important to understand that before changing the drug, you need to consult with your doctor, who will not only help you choose suitable remedy, but also be able to guarantee its maximum effectiveness in each individual case. This is due to the characteristics of the organism, on which different drugs can provide miscellaneous action.

Identical composition

Completely coincide in composition, therefore, in all therapeutic characteristics of 2 drugs: Dufaston and Dydrogesterone. They can replace Duphaston without any harm to the body. However, despite the identical active substance, they have some differences, which you need to know about before taking each of the described means.

1. Dufaston.

Dufaston is a generic known drug. As you know, the generic is completely identical drug, which has a different name since the original was developed by another company that patented it. Dufaston was released by another pharmaceutical company, but its composition is completely identical to its predecessor. The only difference is the price, which can be either higher or lower, depending on the network of pharmacies, the place of sale and the country of origin.

2. Dydrogesterone.

Dydrogesterone, in turn, is slightly different in composition, but has an absolutely identical effect. Its only component is the substance of the same name, which is also the main component of Duphaston, synthetic progesterone. Additional ingredients indicated in the composition are only necessary to create a dosage form and do not affect the effect of the drug in any way. Since production requires minimum costs, then the cost of Dydrogesterone is an order of magnitude lower than that of other funds from this series. The main difficulty of its use is the relative rarity on sale. It is produced in limited quantities and rarely appears in pharmacies. This issue is especially acute for regional pharmacies in remote cities, as well as cities with a small population.

Similar action

The second group of drugs includes drugs that have a different composition, but have the same therapeutic characteristics and evidence that Duphaston. They can be used to treat the same diseases for which the original drug is intended, but they are also slightly different. To fully replace one drug with another, you need to consult a specialist.

1. Morning.

The most popular and well-known analogue is considered to be a drug developed in Thailand, known as Utrozhestan. The main component is natural micronized progesterone. It was obtained with the participation of volunteers, and also synthesized with the help of animals. Wide use he received it precisely because of the naturalness of the active substance, which practically does not cause allergic reactions, unlike artificially created hormone substitutes. Despite all the positive aspects, Utrozhestan has some negative side effects and contraindications:

often provokes headaches and migraines;
may cause itching, hives, allergic reactions, up to Quincke's edema;
causes increased fatigue, drowsiness and decreased performance;
contraindicated in women who are active;
it is forbidden to be taken by women who drive vehicles;
prohibited for use by women who experience bleeding of the birth canal.

That is why the use of Utrozhestan should be agreed with the doctor and prescribed only after an examination and tests that exclude the possibility of manifestation negative consequences from drinking medicinal product. The most important test is a test for allergic reactions and intolerance to the components of the drug.

It is produced in two dosage forms: in the form of tablets, as well as suppositories, which are used intravaginally.

It is Utrozhestan that is considered the most worthy replacement for Duphaston.

It is most similar to natural hormones, which are produced in the female body, and contributes to pregnancy, and also fully prepares the endometrium, creating favorable conditions for egg implantation and successful pregnancy on early stages. To positive aspects This remedy can be attributed to the fact that it does not contribute to weight gain, does not retain fluid in the body, does not affect pressure and metabolic processes.

2. Progesterone.

A drug Russian production Progesterone has the same effect on the female body as Duphaston. At the same time, its main active ingredient is a progestogen, which is also known as the corpus luteum hormone. The main difference between the two tools is dosage form. Duphaston is available as a tablet, Progesterone is only available as an injection. Most often it is used for inpatient treatment in hospitals, because independent use can be quite problematic. Its shape also allows you to accelerate the effect of the drug on the body, which makes it indispensable in the treatment severe forms spontaneous abortion.

The main reason for replacing Duphaston with any of its analogues is the cost. original drug. Almost all analogues have a price several times lower, which makes them affordable for everyone. Most often, the price is determined by the country of manufacture, the company that launched the product on the market, and also official representative and a network of pharmacies that sell and set their own price for medicines.

It's no secret that every year the state environment significantly worsens, which adversely affects the health of people. Without the help of medicines, many women cannot conceive and carry a child. But science does not stand still: there are many drugs that not only increase the likelihood of a desired pregnancy, but also lead to normal women Health. One of these medical "helpers" for the fair sex is the Duphaston remedy. But not only this drug helps to restore the hormonal balance of the female body and allows you to make the dream of a baby come true. The doctor can also prescribe an analogue of Duphaston, and more than one. But which one is better - let's try to figure it out.

Why is Duphaston so good?

Before considering which drug can be a worthy alternative to this medicine, you should understand what properties it has and how it affects the woman's body.

So, dydrogesterone, which is the basis of the drug, in terms of molecular structure, pharmacological and chemical properties close to natural progesterone. It is the deficiency of this hormone that can deprive a woman of the joy of motherhood. Despite the fact that it is a derivative of testosterone, the hormone has no side effects. It is worth noting that this characteristic is a huge benefit of the drug. This cannot be said about many synthetic progestogens, which are necessary components of hormone replacement therapy. Among other things, the drug does not affect the metabolism of carbohydrates and the functioning of the liver, its action does not affect the processes of ovulation and metabolism.

Pharmacokinetics

A feature of the drug "Dufaston" is that it quickly gets out of gastrointestinal tract in bloodstream. The maximum concentration in the blood after taking the tablets is observed after 2 hours. Further, 97% of dydrogesterone binds to proteins and is hydroxylated in the liver cells.

results clinical research confirm that about 64% of the dydrogesterone dose is excreted naturally, with urine. Thanks to this, it becomes possible to determine the endogenous level of progesterone. The instruction will help to obtain more specific information about the pharmacokinetics of the drug "Dufaston".

Analogues of the drug do not have the properties mentioned above.

Indications for use

Before considering the medicines that can replace the drug "Dufaston", you should figure out what women's problems it is prescribed for.

Most often, doctors recommend taking Duphaston medicine to women who have been diagnosed with a progesterone deficiency. The low level of this particular hormone in a woman's body is the cause of many troubles, such as the threat of fetal loss, menstrual irregularities, dysmenorrhea, premenstrual syndrome, infertility, secondary amenorrhea, dysfunctional uterine bleeding.

With all of the above ailments and conditions, doctors do not prohibit taking an analogue of Duphaston tablets, but if the budget allows, they recommend using the original drug.

How to replace the tool "Dufaston"?

To date, the most famous and most commonly used drug, which can fully replace the drug "Dufaston", is "Utrozhestan". But, fortunately, scientists did not stop at the development of only this drug. Therefore, today a woman who wants to conceive and safely endure a crumb can purchase the most suitable option from a wide range of drugs. Of course, it is worth noting that this choice should be made entirely by the doctor, taking into account individual features female patients. But situations in life are different, therefore, after consulting with a pharmacist, you can independently purchase a worthy analogue of Duphaston.

The drug "Urozhestan"

The drug "Utrozhestan" is produced on the basis of vegetable raw materials diogenin - a Mexican plant, better known as wild yam. It has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity. Also, this Russian analogue of "Duphaston" is useful for pregnant women. sedative effect, while not predisposing to weight gain and does not affect the excretion of fluid from the body.

Advantages and disadvantages of the drug "Utrozhestan"

A distinctive negative characteristic of this drug is a significant number of side effects that are not observed when using Duphaston tablets. It could be fatigue, dizziness, drowsiness, general malaise, distraction and other reactions.

But it should be noted that the above side effects fully compensate for the advantageous characteristics of the drug. So, the medicine "Utrozhestan" can be used both orally and intravaginally. This allows you to prescribe the drug not only to pregnant women with early toxicosis, but also to achieve the maximum therapeutic result in the development of other pathologies in expectant mothers.

Attribute to the benefits of the drug can be its cost. After all, this analogue of "Duphaston" is an order of magnitude cheaper than the original. But it is worth recalling that it is strictly forbidden to replace the prescribed medicine on your own. Therefore, before buying this more affordable medication, you need to consult with your doctor, especially if we are talking about maintaining the desired pregnancy.

Means "Dydrogesterone"

Like the drug "Dufaston", its analogues make up for the deficiency of progesterone in a woman's body. In particular, the drug "Dydrogesterone" helps to maintain the beneficial effect of estrogens on lipid profile blood. The active substance of the drug does not affect coagulation parameters, as well as carbohydrate metabolism and liver function. In addition, the advantages of the drug include the absence of androgenic, estrogenic, thermogenic, corticoid or anabolic activity.

To date, the tool "Dydrogesterone" is a good and affordable Russian analogue of "Duphaston". This synthetic progestogen is indicated for endogenous progesterone deficiency.

Means "Prajisan"

This modern analogue"Duphaston" is hormonal agent with progesterone. It is used in the treatment of long-term infertility, as well as insufficiency of the luteal phase. Effective at various violations menstruation cycle, premenopause, fibrocystic mastopathy and other ailments.

Since the drug has more wide range actions than the remedy "Dufaston", it is used only before pregnancy. Exceptions are cases where the benefit to the mother's body exceeds possible risk negative impact to the fruit.

What is the best analogue?

Only doctors have the right to talk about what medicine can replace Duphaston. Analogues of the drug are selected by a professional, taking into account all the individual characteristics of the patient and the complexity of her disease. Self appointment drugs of this group can harm the health of both the mother and the baby, and sometimes cause spontaneous abortion (with a sharp withdrawal of the drug).