Is there an analogue of Ovestin candles. Ovestin analogue - which drugs are similar in composition and action? Ovestin and its action

Ovestin drug contains natural female hormone estriol, which is a hormone short action, and therefore does not stimulate proliferative processes in the endometrium. The drug promotes the regeneration of the epithelium of the vaginal mucosa, the restoration of the pH environment and the natural microflora of the vagina, all this increases local immunity and prevents the development of pathological flora.

Indications for use

- age atrophic changes vaginal mucosa associated with estrogen deficiency (including dryness, itching and discomfort in the vagina, pain during intercourse);
-increased urination, pain when urinating;
-prevention inflammatory diseases urogenital area;
-urinary incontinence;
- for diagnosis, with unclear results of a smear from the vagina for cytology;
- infertility associated with the cervical factor;
- prevention of complications during operations with transvaginal access.

Mode of application

Ovestin can be used both inside, in the form of tablets, and topically, in the form of suppositories and creams. The effectiveness of the drug does not change. Regardless of the route of administration, the drug is used once a day. The cream is usually administered at bedtime, using an applicator.
With atrophic changes in the vaginal mucosa, the following method of application is recommended: 2-4 tablets (4-8 mg) for a month, with a further transition to a maintenance dosage of 1-2 tablets (1-2 mg). With urinary incontinence, perhaps the appointment, in more high dosages. Candles are administered once a day, with the improvement of symptoms, they switch to a more rare introduction - 2 times a week. The cream is injected with an applicator, at the beginning of treatment every day, when the condition improves, they switch to the administration of the drug 2 times a week. The course of therapy depends on the severity of the symptoms of the disease.

Preparation for surgery with transvaginal access, menopausal women: 1 suppository daily, starting 2 weeks before surgery and one suppository 2 times a week, for 14 days after surgery. The tablets are used following scheme: 4-8 mg 14 days before surgery and 1-2 mg 14 days in the postoperative period. The cream is administered according to the same scheme: 14 days before surgery 1 time per day, in the postoperative period - 2 times a week.

With pathological menopause: 4-8 mg, s gradual decline doses as the condition improves.
For diagnosis, with unclear results of a smear from the vagina for cytology: 1 suppository every other day for 1 week before taking the next smear. Cream, in the same way as candles.
For infertility associated with the cervical factor: 1-2 mg per day from the 6th to the 15th day menstrual cycle, sometimes the dose is increased to 8 mg per day.
If you miss the next dose of the drug, if the interval between doses is not more than 36 hours, you must take the missed dose and then continue taking the drug according to the scheme. If more than 36 hours have passed, you just need to continue taking the drug according to the scheme.

Side effects

Local: irritation and itching in the vagina.
General: discomfort and pain in the mammary glands, nausea. Very rarely: headache, increase blood pressure.

Contraindications

Pregnancy.
Intolerance to any of the components of the drug.
Breast cancer in the present, history or suspicion of cancer.
Estrogen-dependent malignant tumor, more often endometrial cancer, or suspicion of this type of tumor.
vaginal bleeding unclear etiology.
An episode of arterial or venous thromboembolism in history.
Liver disease in acute stage or changes in liver function tests.
Porfiry.

Pregnancy

The drug is contraindicated in pregnancy.

Interaction with other drugs

Cases of adverse interactions with other drugs have not been registered, but considering pharmacological properties Ovestin possible interaction with: anticonvulsants(barbiturates, carbamazepine), antibiotics (eg, rifampicin), antiretroviral drugs, with preparations based on St. John's wort.
Possibly estriol may enhance pharmachologic effect some corticosteroids and theophylline.

Overdose

Overdose symptoms Ovestin: nausea, vomiting, vaginal bleeding. There is no specific antidote, treatment is symptomatic.

Release form

Tablets 1 mg, 2 mg No. 30;
Vaginal cream in tube 15 g;
Candles vaginal 0.5 mg №15.

Storage conditions

Store in a dry place, protected from sunlight.
Store cream and suppositories at a temperature of 2 to 25 ° C; tablets at a temperature of 2 to 30 °C.

Compound

Ovestin tablets:
Active substance: estriol - 1 or 2 mg.
Additional substances: potato starch, amylopectin, magnesium stearate, lactose monohydrate, povidone, silicon dioxide.

Candles Ovestin:
Active substance: estriol - 0.5 mg
Additional substances: Witepsol S 58.

Cream Ovestin:
Active substance: estriol - 1 mg / g.
Additional substances: octyldodecanol, cetyl palmitate, glycerin, cetyl alcohol, stearyl alcohol, polysorbate, sorbitan stearate, lactic acid, chlorhexidine hydrochloride, sodium hydroxide, prepared water.

Additionally

Treatment high doses should not last longer than a few weeks.
With prolonged treatment with the drug, careful monitoring of the condition is necessary: control of the coagulogram, examination of the mammary glands, gynecological examinations.

main parameters

Name:	OVESTIN
ATX code:	G03CA04 -

In addition, the hormonal drug is intended for postmenopausal women during operations with the so-called vaginal access. Use medication with diagnostic purpose when results are unclear cytological examination cervix.

What are the contraindications for Ovestin's medicine?

I will list when the hormonal remedy Ovestin (suppositories, cream, tablets) instructions for use do not allow it to be used for medicinal purposes:

breast cancer;
Vaginal bleeding of unknown origin;
Estrogen-dependent tumors, for example, endometrial cancer;
Venous thromboses;
Hyperplasia of the endometrium;
Porfiria;
thromboembolic disease;
Severe disease liver.

In addition, at hypersensitivity to the active substance of the hormonal agent.

What is the use and dosage of the drug Ovestin?

Ovestin cream is inserted into the vagina with the attached applicator, the procedure is recommended to be carried out at night. One application contains 500 micrograms of estriol. In the treatment of atrophy of the mucous membrane of the urinary tract, 1 application per day is carried out for 4 weeks, then the dose is gradually reduced (up to 1 application 2 r per week).

For diagnostic purposes, Ovestin is used in the amount of 1 application every other day for a week before taking the next smear. Do not put the applicator in boiling water after use.

In the treatment of atrophy of the urinary tract mucosa, Ovsestin suppositories are used in the amount of 1 suppository / day for the first 4 weeks or Ovestin tablets 4-8 mg / day, followed by a gradual decrease in dose, based on relief of symptoms, until a maintenance dose is reached (i.e. 1 suppository 2 r per week or in the case of tablets - 1-2 mg / day).

Overdose from Ovestin

In case of an overdose of Ovestin, nausea and vomiting may occur. In this case, the woman is carried out symptomatic treatment.

What are the side effects of Ovestin?

The use of the drug Ovestin can cause the following side effects: itching, local irritation, tension, increase and some, in addition, acyclic discharge from the genital tract of a bloody nature is possible, breakthrough bleeding and also metrorrhagia.

special instructions

Therapy with Ovestin is recommended to be discontinued in that situation, if a woman has the following symptoms: jaundice, increase blood pressure, a headache of the so-called migraine type. To avoid stimulation of the endometrium daily dosage There should not be more than one application.

If, after treatment, a woman feels potential symptoms, for example, she develops shortness of breath, painful swelling of the legs joins, sudden pain in the chest will be noted, then further use of this drug should be suspended, and urgently consult a doctor.

How to replace Ovestin, what analogs to use?

Estriol, Ovipol Clio, in addition, Estrovagin, Estrocad, Elvagin, as well as micronized Estriol.

Conclusion

The use of the drug Ovestin should be carried out on the recommendation of a qualified specialist.

Be healthy!

Tatyana, www.site
Google

- Dear our readers! Please highlight the found typo and press Ctrl+Enter. Let us know what's wrong.
- Please leave your comment below! We ask you! We need to know your opinion! Thank you! Thank you!

Among estrogenic drugs, cream, tablets, and Ovestin suppositories receive positive reviews with menopause in women. The main component of any form of release of this tool is natural estrogen called Estriol. It is effective both during premenopause and to eliminate unpleasant symptoms associated with a lack of estrogen.

Women among the main advantages this drug distinguish its short-term effect. In other words, Estriol is not long contained in endometrial cells, therefore it does not provoke excessive cell division, thereby protecting the endometrium from tissue growth. Therefore, there is no need to cycle progestogens, and bleeding is not observed.

Release form and composition of the drug

This drug in a pharmacy can be found in several versions:

Cream. Produced in special tubes (15 g). In addition to estriol, the composition contains lactic acid, caustic soda, cetyl palmitate and others.
Candles. One pack contains 15 suppositories of 0.5 mg Estriol each. Witepsol S 58 is an additional component.
Tablets. Available in the form of capsules (1 or 2 mg) based on Estriol. One package contains 30 capsules. Additionally, the composition contains starch, lactose monohydrate, amylopectin, magnesium stearate.

There is no particular difference between these forms of release. Such a variety helps a woman to individually choose the drug, starting from the intolerance of additional components and the convenience of using one form or another of the remedy. But still, it is necessary to adhere to the rules for using candles, cream, Ovestin tablets, where in each case there are their own characteristics and recommendations.

The hormone estriol and its benefits for the body

Estriol acts as an active substance of any form of release of Ovestin. Its action is characterized by selectivity in terms of influence on reproductive organs women. After its use, estrogen production is stimulated, due to which:

stops thinning of the walls of the vagina;
inflammatory processes in the tissues of the vagina are stopped;
dryness of the mucous membrane is eliminated;
disappear pain during sex;
increased sexual desire;
stimulates the production of cervical mucus;
blood circulation of the pelvic organs is normalized;
rises natural protective barrier from various infections;
the microflora of the vagina is restored.

Ovestin has a fast, but short-term effect. This medication does not cause bleeding. Excreted by the kidneys (98%), as well as the intestines (2%).
Indications for use Ovestin

Many women take Ovestin as an element to increase estrogen production. Menopause causes a lot unpleasant symptoms where Estriol helps to effectively deal with:

vaginal atrophy;
dryness,;
involuntary excretion of urine;
hot flashes and increased sweating;
infertility (solving the problem with cervical mucus);
urogenital disorders;
painful sensations during intercourse.
other menopausal disorders associated with a lack of estrogen.

Ovestin is very often used before surgical operations on organs reproductive system, and also as a preparation of the recovery period. In addition, the use of the tool is preventive measure on the issue of preventing inflammatory processes and infectious diseases urinary tract and vagina.

Contraindications and possible side effects

This hormonal drug should not be used without medical supervision. After all, it is not suitable for all patients. The main contraindications are:

bleeding with an unknown cause;
suspicion of breast cancer or its presence;
hereditary predisposition to cancer;
various neoplasms;
period of exacerbation of endometriosis;
problems with the liver or kidneys;
individual intolerance to the composition of the product;
epilepsy;
thrombosis.

With extreme caution, treatment with Ovestin is prescribed to women with diabetes mellitus. In this case, the form of the drug is chosen, where there is no lactose monohydrate (candles or cream). You should also consult your doctor if you have cardiovascular diseases or various pathologies.

According to reviews, the side effect of the remedy appears in the first few months of use. The following undesirable effects most often resolve on their own and do not require discontinuation of the course of treatment:

headache;
short-term nausea;
liquid stool;
chest pain;
breast enlargement.

If it appears on the skin allergic reaction, this may indicate individual intolerance drug components. Immediate discontinuation of the course of treatment is necessary in the following situations:

jumps in blood pressure;
systematic headache, migraine;
the occurrence of fainting;
general weakness;
destabilization of liver and kidney functions;
bleeding;
vomit;
jaundice.

Here it is necessary to consult a doctor who will either completely cancel the drug, or reduce the dosage. In addition, other pathological processes in the body.

Useful information and instructions while taking the drug

Before starting any hormone replacement therapy, you must:

pass general analysis blood;
establish blood levels of Estradiol, FSH and LH;
visit a therapist
undergo an ultrasound of the pelvic organs;
get a mammogram;
pass a general urine test;
be examined by a gynecologist;
take a pap test (smear for cytology);
check changes in blood sugar and cholesterol levels;
get tested for osteoporosis.

Taking Ovestin, it is necessary to undergo an appropriate examination every six months so that any pathological changes reveal on early stages and stop the drug on time. In this matter, many depend on the woman herself and her responsible attitude to her health. After all, at wrong approach to the treatment of HRT can cause serious disturbances in the functioning of the whole organism.

In addition, it is important to follow the instructions for using the drug, starting from the release form.

Instructions for using Ovestin

Candles

The suppository must be inserted into the vagina once a day in the evening. For the treatment of problems with the genitourinary system, the course is one month. The first 14 days the candle should be placed daily. Then the dose is gradually reduced. For example, when significant improvement well-being and a decrease in the frequency, intensity of menopausal symptoms, suppositories are already used every two weeks.
If a woman uses suppositories before surgery, then the course is 14 days (one suppository daily). And after the operation, Ovestin can be used for two weeks (two suppositories for 7 days).
With a lack cervical secretions candles are used only a week every other day.
If a woman violated the course (missed one injection of a candle), then the suppository must be placed as soon as possible. But if more than twelve hours have already passed, then the procedure is skipped, and the next candle is introduced according to the treatment schedule.
It is forbidden to enter two suppositories at once into the vagina at a time ( serious violation optimal dosage).
If Ovestin is the first HRT drug in a woman's life, then the course of treatment can be started on any day. And when switching from another drug, a break of one week is necessary (the doctor sets the exact period based on the characteristics of the drugs).
As for the time of use, it is advisable to put the suppositories at the same time. Deviation of one hour is allowed.

Tablets

For one day, the dose should be in the range of 4-8 mg. It is necessary to use at the same time, preferably before bedtime.
For the treatment of vaginal atrophy and menopausal symptoms, the drug is taken for thirty days, adhering to established by the doctor doses. Then the dosage is reduced to 1 mg per day.
Before surgery, Ovestin should be drunk for two weeks at the prescribed dosage, and after surgery, the course is two weeks at 1 mg per day.
To normalize cervical secretions, tablets should be drunk from the 6th to the 15th day of the menstrual cycle, 1 mg each. A monthly increase in the dose is allowed until the discharge is completely normalized.
If you miss a pill, you can take it at any time, but no more than 12 hours after the missed one. In this case, the reception procedure is skipped, and next tablet taken according to the course of treatment.

In the form of tablets, Ovestin is quite simple to use, but the presence of lactose monohydrate makes it impossible for women with diabetes to take.

Cream

The cream is used with a special applicator, which is administered at bedtime.

The dosage corresponds to a candle or a tablet.
Contains 500 micrograms of Estriol.
Dose and application schedule coincides with other forms of release.

should be adhered to next instruction for using the cream:

carefully remove the cap;
open the protective film;
put the applicator on the tube and fill it up to the specified values easy pressure;
securely close the tube with a cap;
the applicator must be inserted into the vagina in the supine position;
we press on the piston only when the applicator is inserted to a sufficient depth;
after use, the applicator must be rinsed in warm water without forgetting to rinse it;
it is forbidden to handle the applicator with boiling water.

Prices for Ovestin

This tool can only be bought with a prescription from your doctor, who will advise the appropriate use case. Ovestin prices may be higher or lower in different regions:

Cream - 1000-1300 rubles;
Candles - about 1200 rubles;
Tablets - 900-1100 rubles.

You can pick up cheaper analogues. But you need to remember that the actions of the funds may differ slightly. Therefore, the price must be taken into account last turn following the recommendations of the attending physician.

Drug analogues

Instead of Ovestin, you can take almost any drug that is based on the same active substance. Among the popular analogues, it is worth highlighting:

Ovipol Clio
Microfollin-forte
Estrovagin
Dimestrol
Elvagin
Tefestrol
Estrocad
Estriol
Klimonorm

But most of the reviews of women indicate that Ovestin nevertheless has an optimal effect on the body, in which there are practically no symptoms. side effects. In addition, it begins to act faster without a lasting effect.

What form of release to choose?

In this matter big influence have a woman's personal preferences. After all different forms release of Ovestin with menopause do not have much difference between themselves. But still it is worth listening to a doctor who will explain the specifics of use, and also explain the effect auxiliary components funds for the body.

Often women note that it is easiest to use candles, but they take longer to dissolve. But the cream is quickly absorbed by the vaginal mucosa, but some patient reviews indicate problems with maintaining the applicator. But the cream quickly eliminates dryness and discomfort in the vagina. With tablets, an overdose most often occurs, the symptoms of which are nausea and vomiting. But if you follow the doctor's recommendations, this factor is reduced to almost zero.

It can be concluded that the form of the remedy must be chosen individually. Ease of use, additional components, etc. are taken into account. And the effect after application remains the same.

Menopause requires a woman to be careful and attentive to her health. If the body does not have enough estrogens, then Ovestin can be used, but only after the approval of the attending physician. Any HRT drug, if used incorrectly, can cause serious side effects that will further complicate life during menopause.

Ovestin cream analogues are vaginal creams, suppositories or tablets, the active substance of which is estriol, it is used to treat symptoms of diseases caused by a lack of estrogen. Doctors note that these drugs are most effective in combating urogenital abnormalities.

Ovestin cream is able to cause the activity of proliferation of the vaginal epithelium, helps to restore its microflora, normalizes blood circulation, has a positive effect on the physiological environment of the cervix and improves the quality of cervical fluid. All these factors provide epithelial cells with immunity against inflammation and infection.

Estrocad

Estrocad is the first analogue of Ovestin, which is presented in pharmacies in the form of candles and cream. It has the same active substance, estirol. The drug cannot be classified as safe in any way, since as side effects in combination with gestagens, it can cause breast cancer, provoke venous thromboembolism or myocardial infarction. Therefore, you should think carefully about such a replacement, it may be better to buy Ovestin suppositories and not look for medicines cheaper.

Estrocad is prescribed for the following diseases

Atrophic disorders of the urogenital tract associated with a lack of estrogen.
In the period before or after surgery in postmenopause.
The ointment can be used to clarify diagnostic data if the tests did not clarify when taking a smear to study atrophic changes.

Contraindications

This Ovestin substitute is strictly forbidden to be used by patients with malignant formations, in particular breast cancer, estrogen-dependent formations or if their existence is suspected.

Other diseases in which Estrocad is prohibited:

endometrial hyperplasia;
venous thromboembolism (including idiopathic);
arterial thromboembolism;
acute liver dysfunction;

Also, the drug is not used by women during breastfeeding and pregnancy.

Important! Long term treatment The estrocad must necessarily include a detailed medical examination every six months while using the medicine. Special attention given to the examination of the mammary glands.

Ovipol Clio

Ovipol Clio is another medicine that is considered as an analogue of Ovestin in the form of suppositories. The price of Ovipol Clio ranges from 510 to 620 rubles. Candles have exactly the same indications for use as Estrocad.

And contraindications include many diseases, these include:

genital bleeding of unknown origin;
venous or arterial thrombosis;
angina;
diagnosed thrombophilia;
otosclerosis;
porphyria;
with hypersensitivity to the composition of the components of the drug;
endometriosis;
with suspicion of malignant tumors;
impaired renal function;
heart diseases;
cholelithiasis;
diabetes;
deviations in the work of the liver;
pancreatitis;
migraine;
bronchial asthma;
thrombophlebitis of deep veins.

Candles Ovipol Clio cannot be used by pregnant women and breastfeeding mothers.

Elvagin

The active substance of Elvagin is Esterol. It is an analogue of Ovestin candles and his cream. It may slightly increase the amount of beta-lipoproteins in the blood, improve glucose suppression and help the liver produce globulin.

When should you not take Elvagin?

With sensitivity to estirol or other components of the drug.
Pulmonary embolism.
Myocardial infarction.
During pregnancy.
During lactation.
Malignant tumors or their possible presence.
endometrial cancer.
Diseases of the liver.
Deep vein thrombosis.

What can be side effects?

Elvagin can cause itching and pain in the area of the mammary glands. If it is used together with gestagens, the drug can cause vascular purpura, dementia, manifest as erythema nodosum, breast cancer, venous thromboembolism, and some benign tumors.

Note! If the drug has been used for long term doctors recommend a thorough gynecological examination and general medical.

Estrovagin

Estrovagin is sold in pharmacies in the form of candles of light cream or white color. The Ovestin analogue contains estirol and witepsol W35. Estrovagin is a hormonal drug that replaces the natural female hormone. The drug is particularly effective in violation of urogenital disorders due to its urotropic activity.

Esterol - as an active substance, unlike other estrogens, only briefly affects the structures that are sensitive to it. This has its advantage, since it is taken once a day, endometrial proliferation will not be provoked.

Indications

HRT - hormone therapy used for atrophy of the lower zone of the urinary and genital tract, provoked by estrogen deficiency;
if the diagnosis was unsuccessful, candles are used to clarify it during cytological studies;
therapy before or after surgery in the vaginal area for postmenopausal women, when an operation will be performed or has already taken place in the vaginal way.

With extreme caution, the appointment of such hormonal drugs is performed in the presence of endometriosis, thromboembolism or if there is a risk of its progression. It is also not advised to use if there is a possibility of developing a breast tumor, arterial hypertension or neoplasms in the liver.

Side effects

Deviations from the norm can manifest themselves in the zone of the mammary glands, namely in the form pain, tension, breast enlargement or acyclic spotting. This is because Estrovagin is not a non-hormonal drug.

Estriol

Estriol is available as a cream, suppositories, or tablets. The drug has a positive effect on the restoration of the vaginal epithelium, if atrophic changes were noticed in menopause or in the postmenopausal period. It also restores the pH of the vagina and its microflora and increases the level of protection against the development of infectious diseases and inflammation.

Contraindications for use

hypersensitivity to the components of the drug;
pronounced abnormalities in the liver;
neoplasms in the mammary glands with reference to hormonal changes in the body;
uterine hemorrhages of unknown origin;
cholestatic jaundice;
period of pregnancy;
while waiting for pregnancy;
arterial and venous thromboses.

Note! Overdose may cause vomiting, unexplained nausea, or unexpected bleeding from the vagina. Particular care should be taken in patients suffering from heart failure, impaired normal operation kidneys, epilepsy, severe liver disease and arterial hypertension.

Indications for the use of Estriol

Increased dryness of the vagina.
Frequent calls.
Mucosal atrophy.
Therapy before or after surgery.
Infertility due to low-quality cervical mucus.
climacteric syndrome.
Dyspareunia.
Urinary incontinence (not advanced stage).

Conclusion

Whatever analogues Ovestin has, cheap or expensive, in the form of tablets, suppositories or creams, the most important thing in choosing a drug is to assess the characteristics of the patient's body and possible risks.

It is also always worth remembering that in no case should you self-medicate and select Ovestin analogues at your own discretion, this can cause irreversible processes and aggravate the problem.

Ovestin is original drug containing estriol. Producing countries - France and Holland. Like any branded drug, Ovestin has cheaper structural analogues and substitutes for similar action.

AT female body and to a lesser extent male gland internal secretion produce specific hormones steroid nature - estrogen. They affect almost everything. metabolic processes needed to maintain homeostasis. There are three subtypes of estrogens: estriol, estradiol and estrone, each of which is responsible for certain biochemical processes. The main component of Ovestin is estriol.

Estriol reaches its highest concentration in the body of a woman during pregnancy, the rest of the time this hormone remains at a relatively low level. Of all three subspecies, estriol is considered the least active and rapidly degrading hormone. However, it was found that estriol has a high specificity for receptors located in the genitourinary system, and therefore it began to be introduced into the treatment of conditions such as mucosal atrophy lower section genitourinary system, in pre- or postmenopausal periods, especially in patients who have undergone surgical interventions on the genitals. Estriol acts in isolation epithelial cells with specific receptors for it, improves trophism, helps restore biocenosis and acid-base balance of the vagina, improves resistance to pathogenic microorganisms, reduces the manifestations of symptoms during menopause.

Ovestin is available in several pharmacological forms: tablets for oral intake, suppositories and in the form of a cream for intravaginal administration:

Tablets, each containing 2 mg active substance are taken orally. The course, frequency of administration, single and daily dosage is selected by the doctor individually for each patient, depending on the pathology and anamnestic data. The maximum daily dosage should not exceed 8 mg.
Suppositories for intravaginal administration: 1 suppository contains 0.5 mg of active ingredient. Usually prescribed 1 suppository once a day for two weeks, the further course is determined by the doctor.
Vaginal cream (1 g of cream is equal to 1 mg of estriol). Pharmacological agent the package contains a special applicator that helps to dose and administer the drug correctly. 1 dose in the applicator contains 0.5 mg of the substance. The drug is administered 1 dose daily for 2 weeks, then according to the doctor's recommendations (usually another 2 weeks, 1 dose twice a week).

Ovestin's analogues in composition are presented in various forms release: tablets, suppositories and in the form of a cream. Complete analogues in composition, containing the component of the same name, are represented by the following trade names:

Estriol.
Estrocad.
Estriol-M pessaries.
Ovipol Clio.
Ornion.
Elvagin.
Estrovagin.

Cheap analogues of Ovestin tablets

Among inexpensive drugs, having indications similar to Ovestin and a similar mechanism of action, but based on a different active ingredient, the drugs Proginova, Microfollin, Klimen and others are isolated.

Proginova

Refers to estrogen drugs, 1 tablet contains estradiol valerate 2 mg. Estradiol is one of the subtypes of estrogen that affects the metabolism of many substances. Proginova contains synthetic estradiol, which is almost identical to biogenic. Estradiol is the most active subtype of estrogen and is required for normal development, functioning and trophism of the female reproductive system and many other tissues and organs. AT male body produced in small amounts by the adrenal cortex.

Proginova is taken daily, 1 tablet for the first 3 weeks. Further, it is recommended to take a one-week break. The feasibility, duration and need for further therapy is decided together with the attending physician. Indications include hormonal replacement therapy in cases of identified estrogen deficiency in postmenopausal women.

Contraindications:

Pathological sensitivity to the components of the drug.
Suspicion or diagnosed breast cancer at any stage.
Estrogen-dependent malignant tumor of any localization.
Bleeding from the genital tract without established cause.
Excessive growth of the endometrium, resistant to treatment.
Violation of the hemocoagulation system, a tendency to thrombosis.
Dysfunctional pathologies, liver tumors.
High levels of triglycerides in the blood.

Ovestin and Proginova contain estrogens in their composition, however, their different fractions: Ovestin has estriol, Proginova has estradiol, as a result of which the drugs have some differences in indications for use.

Side effects:

Cephalgia, dyspepsia.
Skin hyperimmune manifestations in the form of a rash.
Uterine bleeding, changes in the amount of excreted menstrual blood, intermenstrual bleeding.
Changes in body weight, edema.
Pain in the mammary glands.
Deterioration of mood, dizziness, blurred vision, tachycardia.

Microfollin

Synthetic estrogen, 1 tablet contains 0.05 mg ethinyl estradiol. Microfollin contains ethinylestradiol, which is similar to human estrogen. Causes proliferation of the inner layer of the uterus, improves the trophism of the tissues of the female reproductive system. Shows a powerful antiandrogenic effect, as a result of which it is widely used in cancer therapy prostate.

It is taken orally, the dose is selected individually for each patient. With prostate cancer, a starting dose of 0.05-0.1 mg three times a day is prescribed, which is subsequently reduced for maintenance therapy. At prolonged absence menstruation, not associated with pregnancy, is prescribed to women at 0.05 mg daily for 20 days, after which therapy continues with progesterone for 5 days. To stop lactation for 3 days, you need to take 1 tablet daily, then - ½ tablet. For acne - half or 1 tablet daily.

Indications:

Menstrual irregularities (lack of menstruation, low blood flow, uterine bleeding, intermenstrual bleeding).
Cessation of lactation.
Acne.
prostate carcinoma.
Climax.

Contraindications include estrogen dependent neoplastic diseases different localization, malignant neoplasms mammary gland, a tendency to thrombosis and / or thromboembolic complications in history, impaired functioning of hepatocytes.

Unlike Ovestin, Microfollin contains a more active estrogen fraction - ethinyl estradiol, and therefore has more wide range indications and various schemes of application.

Side effects: pathological reactions to the components, cephalgic syndrome, nausea, vomiting, osteoporosis associated with an imbalance in calcium metabolism, pathology bone marrow, its hypoplasia, swelling.

Klymen

It is an estrogen-progesterone drug. 1 tablet of Klimen contains 2 mg of estradiol and 1 mg of cyproterone acetate. Klimen contains synthetic estradiol, which is identical to endogenous estradiol. It compensates for estradiol deficiency that occurs in patients in menopause, thereby reducing the symptoms associated with the onset of menopause.

Cyproterone acetate is a synthetic analogue of endogenous progesterone, which has an active antiandrogenic and antiproliferative effect. Due to the fact that the isolated use of estradiol causes hyperproliferation of the endometrium, the addition of a component of the gestagen series eliminates this undesirable effect.

Klimen is applied according to the following schemes:

If not previously used similar preparations, then Klimen begin to take in the period from the 5th to the 25th day of the menstrual cycle, one tablet daily.
If you need to switch from another hormonal drug Klimen's reception begins immediately after the end of the previous course, without taking a break.

The package contains 21 Clymene tablets in two colors (white and pink), which are used daily. During the first 11 days, take 1 white tablet, the next 10 days - 1 pink tablet. Indications: estrogen deficiency in pre- and postmenopause, prevention of osteoporosis during these periods (in women with increased risk occurrence of the disease.

Contraindications:

Hypersensitivity to components.
Suspicion or established breast cancer, estrogen-dependent tumor of another localization.
Metrorrhagia without a diagnosed cause.
Growth of the endometrium.
Blood hypercoagulation (history of thromboembolism).
The period of pregnancy and breastfeeding.
hepatocyte dysfunction.
Increased levels of triglycerides in the blood.

Klimen differs from Ovestin in more active estradiol and additional component- cyproterone, due to which Klimen can be used and is indicated for patients with an increased risk of osteoporosis. The dosage and method of application also vary.

Inexpensive analogues in candles and gel

Suppositories intended for intravaginal administration and gels containing female sex hormones have their own advantages, including: local impact, in this regard, it is possible to use small dosages, which helps to reduce undesirable effects, reduces the number of contraindications.

Ovipol clio

Drug group - drugs containing female sex hormones of the estrogen series. The active ingredient is estriol, which is contained in 1 suppository at a dosage of 500 mcg. There are many receptors for estriol in a woman's body, which are concentrated mainly in the cells of the uterus, vagina, mammary gland, hypothalamus, pituitary gland, etc.

By binding to receptors located on the surface of the cells of the female reproductive system, the drug improves blood circulation, metabolism, enhances the proliferation of the inner layer of the uterus, balances the acid-base state, normalizes normal biocenosis in the vaginal cavity. Also steroid hormone affects carbohydrate and fat metabolism.

Apply medicine intravaginally, 1 suppository at night (before going to bed). Duration of admission is 2-3 weeks. It is not recommended to take more than 1 suppository per day.

Indications for use:

Estrogen deficiency during menopause or premenopause, manifested by thinning of the mucous membrane of the urogenital tract and other symptoms, pre- and postoperative period(operations with intravaginal access).
Menopause accompanied by characteristic symptoms, bringing discomfort and / or a violation of general well-being.
Infertility (if the cause is due to a cervical factor).
Pain during intercourse, dryness, itching of the vagina, enuresis.
For diagnostic purposes.

Contraindications include hyperreaction to the components of the drug, pathology of the blood coagulation system by the type of hypercoagulability, various manifestations history of thrombosis, severe liver pathology, estrogen-sensitive tumors of the reproductive system, metrorrhagia without an established cause, pregnancy.

The original drug and its analogue Ovipol clio differ only in the price category, the latter is cheaper.

Side effects:

Discomfort, irritation at the injection site.
Tension and pain in the breasts.

estrogel

Natural estradiol in the form of a gel for skin application. 1 g of gel contains 0.6 mg of active substance, with one press 1.25 g of gel is released, which corresponds to 0.75 mg of estradiol. The use of estradiol transdermally allows the drug to act by bypassing the liver, which minimizes bad influence on hepatocytes and increases the half-life.

Estrogel replenishes estrogen deficiency during menopause and premenopause. 1 dose of gel, which is equal to 1 pressing (0.75 mg active ingredient), applied to large areas of intact skin (stomach, forearm, lower back, etc.) thin layer 1 time per day after morning or evening skin dressing. Duration of application is 21-28 days per month. The dose may vary (on average, no more than 2.5 g of gel per day), in the future it is necessary to take a one-week break. Further therapy is determined by the doctor individually for each patient.

Indications:

Postmenopausal or menopausal hormonal deficiency and associated symptoms.
Prevention of calcium loss from bone in postmenopausal women.

Contraindications are similar to the drug Ovipol clio.

Estrogel is different from Ovestin pharmacological form and method of application (Estrogel is a gel intended for transdermal administration, Ovestin is a cream for vaginal administration). The preparations contain different fractions of estrogen, dosages.

Unwanted Effects:

Deterioration of mood, irritability, cephalalgia.
Thrombosis, thrombophlebitis.
Abdominal pain, flatulence, nausea, vomiting.
Benign tumor of the liver, increased levels of liver enzymes, cholelithiasis.
Chloasma, skin rash.
Menstrual irregularities, endometrial hyperproliferation, endometriosis.
Cramps in some muscle groups, peripheral edema, weight changes.

Estrocad

The drug is available in suppositories containing 0.5 mg of estriol. The mechanism of action is similar to Ovestin. Estrocad is used according to the following schemes:

With atrophic manifestations of the lower urogenital tract, 1 suppository daily for 3 weeks, then the dose is reduced and is 0.5 mg (1 suppository) twice a week.
Before and after surgical interventions with vaginal access in women in the post-menopausal period - for 2 days, take 0.5 mg daily (in preoperative period) and 1 suppository twice a week (in the postoperative period).
For diagnostic purposes, it is used for a week every other day before taking a smear.

Indications include estrogen replacement therapy in case of their insufficiency (with dryness and thinning of the mucous membrane of the urogenital tract, pain during intercourse, itching and discomfort in the vagina, enuresis mild degree), in the treatment of menopausal or postmenopausal patients undergoing or after vaginal access surgery. In order to additional diagnostics with suspicion of atrophy, after taking a smear from the cervical canal.

Contraindications coincide with the contraindications of the drug Ovipol clio. Estrocad and Ovestin are similar in all respects, the only difference is different manufacturer and drug prices.

Undesirable effects: tension, engorgement and soreness of the breast, peripheral edema, the presence of transparent mucous secretions, increased blood pressure, muscle cramps, cephalgic syndrome, skin hyperpigmentation.

Drug substitutes in ampoules

Ovestin is not available in the form of ampoules, however, some pharmaceutical companies produce medications, which contain hormonal agents for parenteral use.

Sinestrol

The drug belongs to hormonal drugs used in the pathology of the genital area. The active substance is hexestrol. One ml contains 1 mg or 20 mg of Hexoestrolum.

Hexestrol is an estrogenic synthetic drug nonsteroidal structure. Specifically acting on receptors, it improves metabolic processes, blood circulation, prevents calcium from being washed out of the blood and prevents fragility. bone tissue in postmenopausal women.

The drug is injected deep into the gluteal muscle, 1-2 mg daily, the duration of the course depends on the indication:

With primary amenorrhea - 15-20 days, hypooligomenorrhea - during the first half of the menstrual cycle.
With uterine hypoplasia - 4-6 weeks.
At malignant tumor breast use a 2% solution of 1 ml daily, then gradually increasing the dose to 5 ml.
With prostate carcinoma - daily 3-4 ml of a 2% solution for 2 months, then 0.5-1 ml per day.

Indications: hypofunction of the ovaries, which is manifested by the underdevelopment of the female genital organs, amenorrhea, disorders during menopause and postmenopause, breast cancer therapy in women after 60 years, prostate cancer therapy.

Contraindications: dysfunctional conditions of the liver and kidneys, mastopathy, the presence of foci of endometrioid tissue, metrorrhagia, tumors in women under 60 years of age, diabetes mellitus, blood hypercoagulation and complications associated with it, pathological sensitivity to the components of the drug.

Ovestin and Sinestrol differ active substance, release form, route of administration, course of therapy, indications and contraindications.

Side effects:

Dyspeptic phenomena, cholestasis, flatulence.
Swelling of the limbs.
Cephalgia, dizziness.
Increased thromboembolic risks and related complications.
Metrorrhagia, breast tension and soreness, breast tumors, increased libido, feminization in the opposite sex.
Increased growth of the endometrium
Pain and swelling at the injection site.

folliculin

Refers to estrogens intended for parenteral administration in cases of pathology in the reproductive system. 1 ml of solution contains 1 mg of estrone. The mechanism of action is similar to Ovestin.

Method of application: the drug is administered intramuscularly, the dosage is selected individually. Usually the drug is prescribed 1-2 ml daily for 15-17 days to 1-2 months or more. The next step is progesterone intramuscularly for 5-8 days.

With weakness labor activity or prolongation of pregnancy, 4-5 ml is prescribed 2-3 hours before the introduction of labor-stimulating drugs.

Indications:

Hormonal imbalance due to a decrease in the production of the estrogen component (amenorrhea, genital hypoplasia).
Menopause and postmenopausal period accompanied by deterioration general condition, discomfort and other manifestations.
Infertility due to hypoestrogenism.
Insufficient development of secondary sexual characteristics.
Weak labor activity, post-term pregnancy.

Contraindications are identical to the list of restrictions when taking Ovestin and its other analogues. Folliculin is different active ingredient, method of application and form of release. Undesirable effects are similar to Ovestin.