What helps Mexidol, and how to use all forms of the drug correctly? Mexidol tablets how to take before or after meals. Mexidol how to take before meals or after Mexidol before or after meals

The drug is used in violation of the blood supply to the brain. Often, therapy with this drug is intended to treat people who have had a stroke or heart attack. Complex disorders in the brain can cause certain consequences.

Mexidol injection solution has various contraindications, but often the drug is prescribed to people with impaired blood supply to the brain and during the recovery period after a traumatic brain injury, stroke, heart attack and some other diseases. In this article, we will take a closer look at Mexidol injections: instructions for use, reviews, price, analogues.

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The drug was registered in the system of medicines approved for use in Russia on 08/09/2007 under the number LSR-002063/07

Chemical name: 2-ethyl-6-methyl-3-hydroxypyridine succinate.

• biconvex coated tablets (white, white with a cream tint), 1 unit contains 125 mg of active substance;
• solution (for use intravenously, intramuscularly).

Producer: Farmasoft (Russia).

Conditions for the sale of medicines: prescription.

Mexidol indications during pregnancy and lactation

Due to the lack of evidence of the safety of the drug for pregnant and lactating mothers, it is recommended to refrain from taking during the period of gestation and feeding the baby.

special instructions

It is combined with pharmaceutical preparations that are used in therapeutic practice. In pediatrics, they are not used for special indications, since there is no evidence of safety.
When receiving, you can not drive a car and other vehicles that require speed of reaction.

It is released in the pharmacy network by prescription.

Compound

The basis of the product is ethylmethylhydroxypyridine succinate.

The active substance stimulates the antioxidant system, improves biochemical processes in cells, maintains the level of macroergs, restores blood circulation in the brain, and stabilizes metabolism. This is a non-exhaustive list of active component properties.

To improve the absorption of ethylmethylhydroxypyridine succinate by the body, the following substances are included in the composition:

• Lactose monohydrate;
• magnesium stearate;
• Povidone.

For the manufacture of the shell are used:

• carmellose sodium;
• opadra II white;
• polyvinyl alcohol;
• titanium dioxide;
• talc.

The main characteristics of the drug

The drug has the following properties:

1. cleansing;
2. antioxidant;
3. antihypoxic;
4. anti-stress;
5. anticonvulsant, etc.

Medicine Forms

The drug is available in the form of tablets and solution. Tablets are intended for oral administration, the solution is administered parenterally (ampoules, intravenously or intramuscularly).

The composition of the drug

The basis of the agent is hydroxymethylethylpyridine succinate, a substance that determines the spectrum of its action. The composition of 1 tablet of the drug contains 125 mg of the active substance. In a solution of 1 ml, there are 50 mg of hydroxymethylethylpyridine succinate. The package contains ampoules, 10 pieces with a volume of 2 ml, and 5 ml - 5 pieces. The price in pharmacies is from 428 and 412 rubles, respectively.

Indications for the appointment of the drug Mexidol

The drug is prescribed when there are such indications as:

• anxiety, increased agitation, neurotic state;
• disorder of memory and attention;
• hypertension, pre-stroke condition, stroke;
• traumatic brain injury;
• progressive circulatory failure, the so-called. encephalopathy;
• atherosclerosis of cerebral vessels;
• poisoning with psychotropic substances and neuroleptics;
• oxygen starvation;
• inflammation of the pancreas;
• pancreatic necrosis;
• inflammatory and purulent processes in the peritoneum, the so-called. peritonitis;
• withdrawal syndrome in alcohol dependence.

Contraindications

Do not prescribe the drug to women during pregnancy during lactation. Do not use it to treat children and adolescents under 18 years of age. Diseases of the liver and kidneys are contraindications to the use of the drug. Also unstable blood pressure, prone to a sharp increase. The drug should not be taken by people if they have hypersensitivity to its components:

• hydroxymethylethylpyridine succinate;
• pyridoxine.

People whose working conditions require utmost attention should not take the drug before work. The attending physician must be aware of this. He should offer the patient treatment in a hospital or at home, or pick up analogues of a medication that do not have a relaxing effect.

With prolonged use, the drug can give a side effect, manifested in the form of nausea and drying of the oral mucosa. Also, this effect can take place due to the health condition of the patient.

Skin irritation, redness, itching are the result of a side effect of the drug Mexidol. The drug can provoke an increase in blood pressure if there is a tendency to sharp jumps.

Overdose

When taking the maximum doses of the drug, with a long period of treatment with it, with self-medication, an overdose of the drug may occur. Usually this phenomenon is accompanied by lethargy, drowsiness.

But skin reactions may occur - irritation, redness, itching, as well as drying of the oral mucosa, nausea, thirst. If you experience symptoms of an overdose or side effects of the medication, you should consult a doctor.

Interaction with other drugs

When a doctor prescribes taking Mexidol tablets or injections, he must be aware of the simultaneous use of other drugs. Especially when there is a process of examination by different specialists. Each of them finds a problem in the body and prescribes his own treatment, recommends medicines for taking.

Mexidol is able to enhance the effect of many drugs, especially if these drugs have an anti-stress, sedative, cleansing effect. Often, together with mexidol, actovegin is prescribed, a drug with a positive effect on brain cells. To activate the brain, improve the general condition during alcohol withdrawal, together with mexidol, nootropin (a drug based on piracetam) is used.

Storage conditions of the drug

In unopened form, the medicine can be stored for 3 years. It should be placed in a place inaccessible to children. Additional terms:

• lack of bright sunlight;
• lack of humidity in the storage area;
• air temperature is not more than 25°C.

Price

You can find out how much Mexidol costs on the Internet on the website of an online pharmacy or on the page of a system of medicines registered in Russia.

You can buy the drug at the following prices:

Which pharmacies are better to buy + price

Buy mexidol is not difficult. Mexidol is sold in any city pharmacy, and is available for ordering in online pharmacies, such as:

• Classic;
• pills.ru;
• Zhivika;
• Rigla;
• Apteka.ru;
• My doctor;
• Eapteka.ru.

Below is the average price of mexidol per pack:

• Injections 2 ml, package No. 10 - 410-480 rub.
• Injections 2 ml, package No. 50 - 1750-2000 rub.
• Injections 5 ml, package No. 5 - 400-470 rub.
• Injections 5 ml, package No. 20 - 1380-1530 rub.

What is Mexidol prescribed for?

In the annotation attached to the tablets or solution, you can find out what they help from, and most importantly, how to use the drug correctly.

The instructions for Metadol indicate that the drug provides a therapeutic effect for the following health problems:

• Mild traumatic brain injury, various complications after injury;
• Violation of blood circulation in the brain;
• Encephalopathy of various origins;
• With VVD;
• Mild cognitive disorders of atherosclerotic origin;
• Anxiety disorders characteristic of neurotic conditions;
• Cardiac ischemia;
• Consequences of intoxication caused by antipsychotic drugs;
• Asthenic conditions;
• Relief of the withdrawal syndrome that develops with alcoholism, when neurosis-like, post-abstinence, VVD disorders are noted;
• Prolonged exposure to stress.

The drug is used for both therapeutic and prophylactic purposes.

According to the results of studies that study the effect of drugs on the human body, the following therapeutic effect is noted:

• Elimination of provoking factors that cause convulsions.
• Sleep recovery. Rest becomes strong without anxiety and nightmares.
• Protection of tissues from the oxidation process, which is typical for intoxication.
• Stabilization of the psycho-emotional state, increased stress resistance.
• Suppression of panic attacks to lack of oxygen, other pathological effects.
• Activation of brain activity, improvement of blood flow to brain cells.

Mexidol is prescribed to patients who have negative effects of intoxication as a result of exposure to excessively drunk alcohol.

The active component of the drug effectively copes with the symptoms characteristic of poisoning, promotes the restoration of liver cells, cerebral circulation.

Mexidol - contraindications and side effects

Having found out what Mexidol tablets consist of, indications for the use of this medication, it should be noted that there are some restrictions on their use. Before going on sale and mass production, each drug undergoes laboratory and clinical studies. Their goal is to identify possible side effects and pathologies - conditions in which the use of a medicine can harm the patient's health, worsen his well-being.

Similar studies were carried out for Mexidol. According to the results of the study, experts compiled a list of side effects and contraindications. To determine whether Mexidol can be used by a patient in a particular case, the doctor examines the patient and carefully studies the medical history.

Mexidol - contraindications

Like other drugs, the drug Mexidol has some contraindications. If available, Mexidol tablets are replaced with a similar drug, with a similar effect, but without contraindications.

According to the instructions for the drug, Mexidol is forbidden to use in the following cases:

• children under the age of 12;
• the period of bearing a baby and breastfeeding;
• acute renal failure;
• liver failure;
• individual intolerance to the components of the drug.

Doctors pay special attention to prescribing the drug to patients with high blood pressure, accompanied by hypertensive crises. It is undesirable to use the drug for the treatment of patients with hypotension (predisposition to low blood pressure). Do this only under the supervision of a doctor.

Mexidol - side effects

When a patient takes Mexidol tablets in strict accordance with medical prescriptions, side effects develop less frequently. However, they cannot be completely excluded. In general, doctors say that Mexidol tablets are well tolerated by patients, complaints from them are rare.

However, in some cases, with prolonged use of the drug, the following side effects are possible:

• dryness of the oral mucosa;
• nausea;
• allergic reactions.

Instructions for use

The treatment regimen is developed by the attending physician, taking into account the etiology of the disease and the presence of complications. The instructions detail how to take the tablets.

Daily dosage in quantity 450-800 mg divided into three doses, which are carried out before meals or after.

Experts advise taking the medicine an hour after eating food, so it will be possible to avoid a negative reaction of the body (nausea, dizziness, etc.)

The duration of the course is from 2 weeks to 1.5 months. When eliminating the consequences of alcohol intoxication, treatment with the use of Mexidol is prescribed from 5 to 7 days.

When using the injection form, you should familiarize yourself with the features indicating how to inject the solution:

• Intravenously - drip with a speed of fluid movement of 40-60 drops / min.
• Intramuscularly - in a jet with a slow supply of the substance (injection time is 5-7 minutes).

Therapy features:

• you need to start using the medicine in a reduced dosage (1-2 pieces for the first couple of days);
• the main period of treatment involves taking the amount of the drug that the doctor prescribes;
• 2 days before the end of therapy, it is recommended to gradually reduce the dose to 1-2 tablets per day.

To eliminate pathological processes in coronary heart disease, a longer course (up to 2 months) is recommended.

The same terms are set for VVD, traumatic brain injury and during the rehabilitation period, including the stabilization of the psycho-emotional background.

What is the difference and which is more effective?

Patients are often interested in what is better Medomexi or Mexidol. In fact, these are identical drugs, which are based on the same active ingredient. Both drugs have a similar principle of action on the body. They belong to the same drug group, so they can be considered absolute analogues.

Do not forget that the primary drug is Mexidol. During its existence, it has passed a much larger number of clinical trials. According to statistics, it is suitable for most patients and has a small list of side effects.

Among themselves, the funds differ primarily in cost. Medomexi, both in ampoules and in the form of tablets, costs several times more. Many experts are of the opinion that it is better to give preference to the original medicine.

They explain this by the fact that such a drug will be more reliable and safe. However, each patient has the right to build on their own wishes and preferences. The main thing is not to self-medicate, so as not to harm your own body.

Contraindications

Mexidol is not used in therapy if the following factors are present:

• Pregnancy. lactation period.
• Negative reaction of the body to the constituent components.
• Liver / kidney failure (acute form).

Pharmacology

The drug will help to cope with neurasthenia, atherosclerosis, has nootropic, antioxidant, anticonvulsant properties.

In addition, the drug helps:

• Restore lipids of cell membranes;
• Improve the activity of the brain, activating it, due to which learning increases and there is a positive effect on memory and general mental activity;
• Improve the functioning of the organs and tissues of the body in case of insufficient saturation with oxygen;
• Significantly reduce oxidative processes in cells;
• Restore the level of cholesterol in the body;
• Reduce the level of fear, anxiety and excessive anxiety.

The pharmaceutical product is also able to overcome the acute form of a disease such as pancreatitis. The drug allows you to reduce the intoxication of the body during the treatment of this disease. Treatment with this medication is carried out in a complex manner, including patients who have circulatory disorders of the brain, which has an acute form. The use can reduce the pronounced course and symptoms of ischemic stroke, as well as increase the steady state in case of lack of oxygen in the body.

The agent under consideration qualitatively copes with toxins, reducing their negative effects on the body that enter it when drinking alcohol and various drugs. In addition, this medicine allows the body to better cope with stress and well tolerate the effects of hypoxia - the presence of low oxygen in the human body.

Interaction

There are no special prescriptions for the combination of Mexidol with other drugs intended to eliminate somatic problems.

Simultaneous intake of tablets and an ethyl product has a neutralizing effect on toxins.

In complex treatment, it should be taken into account that Mexidol has an enhancing effect on the action of the following groups of drugs:

• antidepressants;
• antiparkinsonian and anticonvulsant drugs;
• benzodiazepines;
• anxiolytics.

Side effects

Before prescribing a medicine, the doctor examines its description, excludes contraindications, side effects, incompatibility with other pharmacological groups as part of complex treatment. This allows you to exclude the deterioration of the general well-being of the patient, from which recovery is accelerated.

After prescribing the drug, keep in mind that Mexidol gives the following side effects:

• signs of dyspepsia of varying severity;
• local allergic reactions.

Mexidol and alcohol: compatibility

One of the therapeutic effects is reducing the effects of intoxication after drinking a lot of alcohol.

This fact is perceived inadequately by many patients, they believe that medicine and alcohol are allowed to be consumed simultaneously.

This is a misconception, refuted by the following factors:

• the active component of the drug helps to restore damaged cells, but does not completely protect against toxins;
• tablets are prescribed in the presence of mental and physical disorders, manifested due to excessive amounts of ethanol.

Experts advise taking the remedy only to improve well-being, correct existing violations.

Mexidol, penetrating into cellular structures, eliminates pathologies, but does not ensure the neutralization of the drunk dose of alcohol. With an uncontrolled combination of synthetics and toxins, the consequences can be unpredictable.

Mexidol: mechanism of action

The drug reduces the formation of peroxide substances that destroy cell membranes, which leads to an increase in oxygen delivery to tissues and the preservation of tissue structures.

Mexidol activates enzymes: superoxide dismutase, calcium independent phosphodiesterase, acetylcholinesterase.

This improves the transmission of nerve impulses in synapses and binding to ligands. Mexidol increases the formation of neurotransmitters, in particular dopamine.

The drug triggers glycolysis reactions and provides oxidative processes of the Krebs cycle during tissue hypoxia, which maintains the formation of ATP, creatine phosphate at the required level.

Reviews of patients taking the drug

Irina, 31 years old:

After a traumatic brain injury, she underwent long-term treatment and rehabilitation. The complex therapy included the drug Mexidol (injections). I don’t even question the effectiveness, which is confirmed by an impressive list of pathologies, from which the medicine helps. My recovery has been very intense. But a fly in the ointment is a complex process of resorption of the solution after an injection. Of the 10 injections prescribed by the doctor, I was able to withstand 7 injections.

For several weeks after discharge, discomfort persisted in the tissues where the drug was injected.

Natalya Fedorovna, 53 years old:

The constant flickering of flies before my eyes and headaches forced me to consult a doctor, who diagnosed atherosclerosis of cerebral vessels. I took Mexidol for about 3 weeks. All symptoms completely disappeared after 10 days of taking the pills, but the doctor advised me to complete the course completely.

After the treatment, I noticed that I began to react more calmly to stressful situations, my heart pains also decreased. For 3 months, her blood pressure was the same as that of an astronaut, although earlier she often took medication for hypertension.

Timur, 40 years old:

I was prescribed Mexidol, Ceraxon and Gordox after the diagnosis of stroke (hemorrhagic type) was confirmed. The first day I could not get out of bed, I constantly felt sick and hurt all over my body, muscles, joints, and even touching the skin caused discomfort. On the fourth day I was able to get up, and most importantly, walk calmly. I did not expect such an amazing effect.

A roommate with a similar disease was prescribed Actovegin-Neuroxon, which also gave good results. Doctors, when I asked about the effectiveness of drugs, answered that the therapeutic effect largely depends on the characteristics of the body, so the selection is carried out individually.

The principle of action of drugs

Medomexy stabilizes the structure of platelets and red blood cells, and also reduces the level of cholesterol in the blood. The active component, penetrating into the body, begins to inhibit lipid peroxidation and restore the cell membrane.

The drug increases the ability to work and concentration, has an antiepileptic effect. It also helps to cope with the symptoms of alcohol intoxication. In addition, the medicinal substance does not cause drowsiness.

Mexidol slows down or prevents the process of peroxidation of membrane lipids. The mechanism of action is also determined by the properties of the main active substance, so taking the medicine contributes to:

• decrease in lipids;
• increased activity of superoxide dismutase enzymes;
• improve the fluidity of cell membranes.

Injections and pills help to strengthen the body's resistance in the event of stressful situations. Also, the drug helps in the treatment of cardiac pathologies, the development of which was provoked by oxygen starvation.

Reviews of neurologists

Neurosurgeon, work experience 12 years, Tishkin A.I.:

I have been using Mexidol practice for quite a long time. During this period, he noted high efficiency in the treatment of vascular pathology, especially when combined with other drugs, for example, with Vasobral. Side effects are rare, the tablet form is easily tolerated by patients.

Intramuscular injections for adults are given according to a special technique, which involves slow injection of the solution (for 5-7 minutes). Then it will be possible to avoid pain after the injection.

Neurologist, candidate of sciences, V. V. Smelyantsev:

The drug shows itself well both in an independent form and in combination with other drugs. It is used mainly for VVD, TBI, diffuse lesions of brain tissues, coronary artery disease, anxiety disorders, asthenia, and other pathologies. A convenient dosage of the active substance makes it possible to choose the most suitable therapy regimen.

When used correctly, side effects are not observed. No overdose effects have been noted in my entire practice either. The indisputable advantage of Mexidol is a wide range of indications.

The action of injections, reviews

The ability of mexidol injections to influence a variety of diseases is associated with its antioxidant, nootropic, membrane-stabilizing, antihypoxic and anxiolytic properties. In addition to them, the medicine helps the body resist stress, improve memory, prevent seizures and affect the amount of certain lipids.

Action of injections

The active substance has the most pronounced properties of an antioxidant and a membrane protector. Due to this, it inhibits oxidative reactions and the activity of free radicals. The result is:

• Ascending superoxide dismutase activity.
• Increase ratio of lipids and proteins.
• Decrease viscosity of cell membranes and increase their fluidity.

Mexidol normalizes work membrane-bound enzymes, including acetylcholinesterase, adenylate cyclase and phosphodiesterase. Due to this and the effect on receptor complexes, the following occurs:

• improving the ability of complexes and enzymes to bind to ligands;
• normalization of the movement of neurotransmitters;
• maintaining a healthy state of biological membranes;
• improved transmission of neurotransmitter synapses.

Medicine helps the body better resist the lack of oxygen, diseases and various aggressive factors. It fights the symptoms of ischemia, shock, drug and alcohol poisoning. The action of Mexidol injections causes increase in the amount of dopamine, normalization of metabolic processes and cerebral circulation, improvement of blood rheological parameters and its microcirculation.

Reviews of doctors

Below are reviews on Mexidol from doctors.

Zinchenko A.V. ENT, 9 years of experience: Mexidol is often used in ENT practice for the treatment of both acute and chronic sensorineural hearing loss in adults and children. The course of treatment consists in intravenous administration of the drug for 10 days. I am glad that the price in pharmacies corresponds to the quality of the medication. Use strictly after consulting an audiologist and having a conclusion in the form of an audiogram.

Lisenkova O.A. neurologist, 13 years of experience: Well tolerated, used in combination with many other drugs. It has a mild anti-anxiety and sedative effect. Positive effect on blood flow. It is used for many neurological diseases and conditions, for example, for various encephalopathies, autonomic dystonia syndrome. Permissible intramuscular, intravenous use and ingestion.

Yakusheva A.E. narcologist, 16 years of experience: A good drug for various diseases: narcological, neurological, therapeutic, vascular, etc. I did not find any cons. I use it in my practice in the treatment of hangover syndrome in combination with other drugs in injectable form and in the future I prescribe mexidol in tablets as a course treatment. I advise you to take Mexidol as prescribed by your doctor! Do not self-medicate.

People's reviews

Nicholas: A certain sense of anxiety has been bothering me lately after failures in business. Mexidol intramuscular injections were prescribed. There were no side effects. It got a little better, but I can’t say that Mexidol really helped me. I will repeat the course of treatment with Mexidol and, probably, then Mexidol will help more. I think that if the doctor prescribes therapy, then you can not refuse. Hoping for the best.

Regina: A diagnosis of dystonia was made. They appointed Galidor. So it made me dizzy. Replaced with Mexidol. The dizziness has subsided.

Natalia: An aunt was taking a course of mexidol while recovering from a stroke. The drug was satisfied. The functions of speech and memory were normalized. No side effects.

Video

Below is a short video about the drug.

Analogues

Analogues of the drug are selected exclusively by the attending physician, sometimes with the assistance of highly specialized specialists.

Effective substitutes include:

Pharmacies also sell cheap analogues:

When prescribing an injection form, you can find an analogue of Mexidol in ampoules:

Solution application

The drug is administered into the body by injection or dropper. For a day, the dose of the drug should not exceed 1.2 g. In the case of a pathology of the cerebral blood flow, the drug is administered using a dropper no more than 4 times a day. Doses - from 0.2 to 0.5 g of each injection. This dosage should be followed for the first 2 weeks of therapy. After this period has passed, it is necessary to switch to intramuscular administration of the drug. Injections should be done 3 times a day. The volume of the drug for each injection should be from 0.2 to 0.25 g. It is this method of drug treatment that can provide the maximum effect.

Actovegin or Mexidol: which is better?

Both drugs are designed to eliminate neurological disorders.

Means show good therapeutic results in various pathologies of cerebral vessels. It is rational to use them to obtain an antihypoxic effect.

However, with a more detailed acquaintance with the pharmacological qualities, it is easy to find out what the difference is:

• Mexidol is a new generation drug that provides an antioxidant effect. The active substance has a wide range of actions: nootropic, anticonvulsant, sedative, hypolipidemic. The effect of Actovegin looks more modest: neuroprotective, regenerative.
• Mexidol is a self-sufficient remedy used to eliminate pathologies in withdrawal symptoms with characteristic signs: anxiety, intoxication, etc. Actovegin is not used in such therapy.

It is impossible to determine which is better due to significant differences in pharmacological properties and other factors associated with the degree of complexity of the patients' disease.

It is also incorrect to ask whether which is more efficient: Mexidol or Cavinton. The range of applications for the first drug is wider, but Cavinton has a pronounced vasodilating effect due to the high concentration of the active substance. This advantage creates some restrictions for the use of the drug, for example, in cardiovascular diseases.

No matter how much the differences, common properties and breadth of the spectrum of the use of drugs are considered, there can be no unequivocal answer.

In any case, only the attending physician is engaged in the selection of drugs, who has a complete picture of the disease, has the opportunity to observe the body's response to therapy.

Mexidol - analogues

When prescribing Mexidol, which injections or tablets are better in a particular case, doctors determine according to the clinical picture. In acute disorders requiring quick, emergency care and the need for an early onset of effect, the drug is used in the form of a solution. The medicine is administered intravenously or intramuscularly.

In some cases, in the absence of the effect of the use of Mexidol, it becomes necessary to select a similar drug.

Among drugs with a similar mechanism of action and therapeutic effect:

• Neurox;
• Cerecard;
• Hypoxen;
• Riluzole;
• Vitagamma;
• Emoxybel.

Mildronate or Mexidol - which is better?

When choosing a medicine for cerebral vessels, doctors can replace Mexidol with Mildronate. This drug significantly improves cerebral circulation, so it is more often used if necessary to prevent strokes. It does not affect cell membranes, does not have anticonvulsant and sedative properties, therefore Mexidol is used for these symptoms.

Neurox or Mexidol - which is better?

Thinking about how to replace Mexidol in case of cerebrovascular accident, brain damage, doctors resort to the help of Neurox. The composition of this drug contains the same active substance, which has a pronounced metabolic and antioxidant effect. A distinctive feature is the release form: Neurox is available only in ampoules and does not have a tablet form. Because of this feature, the need to replace Mexidol may arise in cases where this drug in the form for injection does not bring the expected result.

Cytoflavin or Mexidol - which is better?

In cases where Mexidol cannot be used, the analogue of this drug, Cytoflavin, becomes the main drug in the course of therapy. It copes well not only with protecting cells, but also contributes to the active restoration of brain functions after a stroke. Cytoflavin copes well with the chronic form of cerebrovascular pathology, the consequences of this disease.

The advantage of Cytoflavin is that it has fewer contraindications. The medicine can be used to treat patients with liver failure. It should be noted that Cytoflavin contains a larger amount of active ingredient compared to Mexidol tablets. This accelerates the onset of the desired therapeutic effect. Treatment with Cytoflavin lasts no more than 25 days, while Mexidol has to be used for at least a month.

Detailed description

Mexidol (in Latin Mexidol) is a drug based on ethylmethylhydroxypyrine. The substance acts as a protector of cell membranes from the harmful effects of free radicals. It is used to treat a large number of mental pathologies.

Ethylmethylhydroxypyridine succinate allows you to normalize the oxygen supply to tissues and the process of its absorption. It improves memory, reduces the harm of exposure to toxins (especially against the background of alcohol), increases the body's resistance to the occurrence of pathologies associated with oxygen deficiency.

Important! According to clinical data, the drug has a positive effect on blood vessels in the event of atherosclerotic changes, platelet aggregation and problems with cerebral hemodynamics.

Mexidol in ampoules is injected into a vein, as well as intramuscularly. Once in the blood, it begins to act quickly and carry out chemical and biological processes that are very different from other drugs. Why are Mexidol injections prescribed? It has a wide spectrum of action, injections are prescribed for various forms of diseases.

1. The drug activates metabolic reactions, improves microcirculation, reduces blood viscosity and improves cerebral circulation. Protects the cell membranes of erythrocytes and platelets from destruction, lowers cholesterol levels.
2. Normalizes redox processes in brain cells.
3. Mexidol relieves the symptoms of alcohol intoxication during withdrawal symptoms. Restores cognitive functions, eliminates vegetative imbalance after prolonged binges.
4. Enhances the effect of other drugs: tranquilizers, antipsychotics and anticonvulsants.
5. Mexidol helps with depression, improves memory and increases learning ability.
6. Taking mexidol in coronary heart disease helps to preserve the myocardium by strengthening the membrane of myocardiocytes, as well as protecting the vascular wall from cholesterol deposition.
7. Promotes the formation of collateral circulation in conditions of myocardial damage after a heart attack.

Important! The drug is used in order to facilitate the recovery period after a stroke. Thanks to him, the risk of recurrent stroke is greatly reduced.

Drug properties

The main active ingredient of the drug is ethylmethylhydroxypyridine succinate. This substance is actively involved in all metabolic processes in the body, normalizing them. Therefore, the drug regulates the work of many organs and systems. The normalization of metabolism in the body occurs due to the fact that the active substance of the drug has the following properties:

• inhibits the activity of free radicals and protects cells from their effects;
• reduces the need for cells in oxygen, which makes it easier for tissues to tolerate hypoxia;
• improves the condition of the walls of blood vessels;
• stabilizes the membranes of erythrocytes and platelets, preventing the formation of blood clots and preventing the destruction of blood cells;
• improves the condition of brain cells and mental abilities;
• regulates the action of the autonomic nervous system;
• protects brain cells from damage;
• enhances the effect of tranquilizers, hypnotics, antidepressants and neuroleptics, which allows to reduce their dosage.

drug interaction

The drug Mexidol is able to enhance the pharmacological power of anxiolytics, antiparkinsonian drugs, anticonvulsants. At the same time, the membrane protector minimizes the toxic effect of ethyl alcohol.

Mexidol is combined with all pharmacological products that are prescribed for somatic disorders. At the time of active therapeutic effect on the patient, if possible, driving any vehicles should be abandoned. A similar rule applies to those areas of human activity where maximum concentration of attention and speed of reaction are required.

Opinions of patients and doctors

The drug "Mexidol", reviews indicate this, is a very successful drug in Russian pharmaceuticals. This is an effective medication that can help with impaired blood circulation in the brain. Relief after taking it is also experienced by people suffering from alcohol addiction. After a course of therapy, they have a withdrawal syndrome, and the craving for alcohol also decreases.

There are also negative opinions. They are associated with side effects after taking the remedy, such as headache, nausea or drowsiness. These reactions are rare and occur, as a rule, due to hypersensitivity to the composition.

The medicine is not prescribed for children. However, doctors say that there is a practice of using the remedy for injuries of the skull and brain in children. According to the instructions "Mexidol" in injections in this case, it allows you to get rid of the signs provoked by oxygen starvation. Vegetative-vascular dystonia, which affects a third of the population, is also treatable with this antioxidant.

Mexidol for prevention

The use of Mexidol for preventive purposes is most common to improve the general well-being of a person, as well as for various types of vascular dystonia. Often it is prescribed for the prevention of stroke. It is impossible to take the drug constantly: before you start therapy, you should consult your doctor.

The dose of medication for prevention is much lower than for treatment. In addition, after a course of its use, it is necessary to take a break, after which, on the recommendation of a doctor, prevention can be started again.

For preventive purposes, as a rule, only tablets are used, because. Mexidol injections have a positive effect on the patient's condition, but have a much higher dosage.

You may be interested in reading the article "Instructions for the use of Corinfar".

Ethoxydol's analogs

Analogues are prescribed for treatment:

1. Carnitine;
2. Phenosanoic acid;
3. Tykveol;
4. Neurox;
5. Astrox;
6. Octolipen;
7. Yantavit;
8. Enerlit;
9. Bemitil;
10. Elkar;
11. Epigallocatechin;
12. Medical oxygen;
13. Emoxipin;
14. Rimecore;
15. Cerecard;
16. Dimephosphone;
17. Antisten MV;
18. Laproth;
19. Kudesan;
20. Cyto-Mac;
21. Levocarnitine;
22. Vixipin;
23. Glation;
24. Carditrim;
25. Angiosil retard;
26. Trimet;
27. Cardioxipin;
28. Cytochrome C;
29. Mexidol;
30. Meksidant;
31. Neurolipon;
32. Preductal;
33. Carnifit;
34. Proxipin;
35. Histochrome;
36. Thiotriazoline;
37. Polition;
38. Trekrezan;
39. Hypoxen;
40. Sodium oxybutyrate;
41. Rexod;
42. Kudevita;
43. Vitanam;
44. Mitomin;
45. Solcoseryl;
46. Confumin;
47. Probucol;
48. Mexifin;
49. Deprenorm MV;
50. Limontar;
51. Olifen;
52. Neurocard;
53. Echinochrome;
54. Actovegin;
55. Dihydroquercetin.

What helps "Mexidol": indications

The medication is prescribed for:

• abnormalities in the brain as a result of atherosclerosis;
• vegetovascular dystonia;
• pancreatitis;
• withdrawal syndrome;
• violations of the cerebral circulation of blood flowing in an acute form;
• peritonitis;
• acute poisoning with neuroleptics;
• pancreatic necrosis;
• tissue hypoxia;
• anxiety;
• neurotic and vegetovascular disorders;
• states, as a result of exposure to extreme factors.

Pharmacological properties

Before considering what Mexidol is prescribed for and how to take it, it is necessary to say a few words about the effect the drug has on the human body. Its constituent components provide:

• protection of cell membranes from the effects of free radicals;
• blood oxygen saturation;
• relieving nervous tension, calming the nervous system;
• elimination of seizures.

Ethylmethylhydroxypyride succinate is also a nootropic substance, it improves memory, increases the level of learning, eliminates the negative impact from the outside on these processes. Its reception helps to improve brain function, restore the sleep-wake cycle.

The main task of the drug is to provide lipids of cell membranes with protection from peroxidation, increase their viscosity, and activate the work of enzymes that promote the breakdown of peroxide radicals. Mexidol also starts regeneration processes in membranes, due to which their structure and functionality are restored.

Taking the medicine resumes the process of energy formation in the mitochondria of cells, accelerates the transmission of electrical impulses in synapses. With its systematic use, there is an improvement in blood circulation, its rheological properties increase, and the level of "bad" cholesterol decreases.

Due to these properties, Parkinson's disease is most often treated with Mexidol. Its active ingredients enhance the therapeutic effect of tranquilizers, neuroleptics and antidepressants. This allows you to reduce doses, which reduces the burden on the liver, and avoid most side effects.

Composition and form of release

What is Mexidol? The active substance is ethylmethylhydroxypyride succinate. The drug belongs to the group of antioxidants of a new generation. Release form - tablets, solution for injection. In addition to ethylmethylhydroxypyride succinate, the tablets contain:

• lactose;
• carmellose;
• magnesium stearate;
• talc;
• canrogol;
• titanium dioxide;
• polyvinyl alcohol.

Solution for injection contains the following excipients:

• injection water;
• sodium metabisulfite.

Indications for use

Indications for the use of Mexidol are different. It is used for various diseases that are characterized by a deterioration in the general condition, circulatory disorders, neurological disorders, etc.

In neurology, the drug is used to treat:

• violations of the head circulation;
• dyscirculatory encephalopathy;
• disorders of the autonomic system;
• cognitive problems of atherosclerotic origin, manifested by memory and attention impairment, speech impairment, etc.

Talking about what Mexidol helps with, it must also be said that it is often prescribed for mental disorders that occur against the background of:

• withdrawal syndrome in alcohol dependence;
• poisoning with neuroleptics, which are often prescribed for psychosis;
• neurosis, accompanied by increased anxiety, a sense of fear.

Quite often, the drug is used for osteochondrosis of the cervical region. What is it for? In this case, the active substance provides the following actions:

• reduces the intensity of cervicogenic headaches and dizziness;
• eliminates noise and squeak in the ears;
• restores impaired visual functions (flickering before the eyes, goosebumps, ripples);
• reduces the manifestations of neurological disorders (paresis and paresthesia).

Also, considering the indications for the use of Mexidol, it should be noted that it is often used in surgery to treat inflammation and purulent processes in the abdominal cavity (for example, with peritonitis or necrotizing pancreatitis).

You can buy the drug in pharmacies only by prescription

Mexidol is a universal remedy that has a versatile effect on the human body. It allows you to establish microcirculation of fluids in the blood and lymphatic vessels, improve the neurotrophic parameters of tissues, reduce the degree of endogenous intoxication, etc. That is why the drug has a wide range of applications and is used in almost all areas of medicine.

Action features

Before prescribing the drug "Mexidol", the doctor must take into account contraindications. But the low toxicity of the drug allows it to be used in many cases. This remedy has received wide distribution due to the peculiarities of its action on the patient's body:

• normalizes blood circulation;
• improves blood supply and tissue nutrition;
• increases the degree of concentration;
• improves memory;
• normalizes the level of cholesterol in the blood;
• increases the level of hemoglobin;
• stimulates the production of the hormone dopamine;
• relieves headaches;
• restores the work of the heart muscle;
• increases the body's resistance to stress;
• normalizes the composition and properties of blood, improves its fluidity;
• restores normal sleep;
• slows down the aging process of the body.

Origin

Both drugs, mexicor and mexidol, are drugs from the group of antioxidants, with the same basic substance called ethylmethylhydroxypyridine succinate. Often, when describing mexicor, it is mentioned that it is an analogue of mexidol. However, this is not entirely true. Such statements appear due to the fact that non-specialists often do not distinguish between the terms "generic", "analogue" and "synonymous" in relation to drugs.

The difference between these terms can be seen on the example of mexidol and mexicor.

Generics are medicines that are manufactured according to a formula purchased from an exclusive manufacturer. Typically, a drug formula is sold 20 years after the start of production of the drug: by this time, as a rule, the patent expires. Since the drug is no longer exclusive, the price of it is reduced. But at the same time, the composition of the drug remains unchanged. At the same time, a pharmaceutical company that acquires a formula, with the composition unchanged, can change the name of the drug, starting its production on its own lines.

This is exactly what happened with mexidol, which is a generic drug oxipim. Now oxipim has been completely ousted from the pharmacological market by its generics.

Mexiprim appeared on the drug market later, hence the assertion that it is an analogue of mexidol. However, analogues are medicines produced by the same pharmacological group, but with different active substances. Here, as already mentioned, both drugs have the same basis.

Therefore, it is most correct to call mexiprim a synonym for mexidol: synonymous drugs differ in name, but not in the main component.

A small note: if we can determine synonymous drugs ourselves or with the help of a pharmacist, choosing what is in the nearest pharmacy or what is most suitable for the price, then analog drugs should be selected only by the attending physician. And the difference in this case will not be in price, but in what suits the patient better.

special instructions

Instructions for the use of both drugs contain information about the features of their use in accordance with the age and condition of the body.

Pregnancy and lactation

There is no reliable information about the effect of drugs on the body of a pregnant woman and the fetus, as well as on the penetration of components into breast milk, so drugs are not prescribed during these periods.

Childhood

Not used.

Elderly age

There is no need to adjust the dose.

My result of taking Mexidol

In the first days after the fall, I had a little headache, especially when making sharp turns. In addition, I felt dizzy when getting out of bed. After taking Mexidol, these unpleasant symptoms began to gradually disappear. By the end of the first week, I walked with the child without fear, followed his movements around the playground and was not afraid to run up to him, to pick him up at the right time.

I continued to drink the medicine and felt a general improvement in health. First of all, this was expressed in the appearance of a sound night's sleep. I quickly fell asleep and woke up only from the alarm. At the same time, I felt refreshed and rested. My working capacity has increased, I have strength for evening walks. In addition, I became more calm and balanced.

Treatment regimens and dosage

This subject of discussion lies solely in the plane of prescribing a drug to a specific patient with a specific disease by a specific doctor. Only the attending physician can determine the treatment regimen, based on the anamnesis - just like the doctor chooses which medicine is best to take, mexidol or mexicor. Changing the dosage is also the prerogative of the attending physician, who observes the patient, monitors the change in his condition in one direction or another. And it can make changes to the treatment regimen, increasing or decreasing the dose of the drug, or even removing it from the list of drug treatment.

Calming agents for stress

Sedatives for depression and neurosis

Drugs and pills for fear and anxiety

Overdose

Chewable tablets

The development of an overdose is unlikely due to the low toxicity of Ethoxidol.

Main symptoms: sleep disorders (in the form of drowsiness, insomnia).

Symptomatic therapy is indicated.

injection solution

Main symptoms: sleep disorders (in the form of insomnia, sometimes drowsiness); with a / in the introduction - a short (no more than 1.5-2 hours) and a slight increase in blood pressure.

Overdose symptoms usually disappear on their own within 24 hours and do not require therapy. In severe cases, insomnia is prescribed 10 mg of nitrazepam, 10 mg of oxazepam or 5 mg of diazepam. With an excessive increase in blood pressure, drugs with antihypertensive action under the control of blood pressure are indicated.

Analogues of an antioxidant drug

The high price of Mexidol makes it not the most popular medicine among Russian buyers.

However, there are cheaper alternatives:

• Mexiprim;
• Neurox;
• Meksidant;
• Cerecard;
• Mexicor;
• Mexifin;
• Ethylmethylhydroxypyridine succinate.

All these preparations are created on the basis of the same active substance, however, they contain additional components. Therefore, before replacing Mexidol with another medicine, you should familiarize yourself with all the side effects of the analogue medicine and make sure that you have no contraindications that make its use dangerous.

Alcoholism treatment

In narcology, the drug "Mexidol" is often used. Its use and contraindications in this area have been studied quite well. And this tool is considered one of the best for the treatment of alcoholism. "Mexidol" not only removes toxins and relieves intoxication. It helps to stop the withdrawal syndrome, restores autonomic functions, and is used for behavioral disorders. The advantages of its use include that it is compatible with ethanol and even reduces its toxic effects, allowing the patient to gradually give up alcohol. Treatment lasts from 2 weeks to 2 months, and the withdrawal of the drug should be gradual.

Dose

The daily dosage of mexidol depends on the disease for which this drug is prescribed, the age of the patient and the degree of the disease. Tablets are usually prescribed to take 1-2 per day. The duration of treatment can be very long, up to 6-7 weeks.

When it comes to intravenous or intramuscular injections, then usually the dosage is calculated based on the patient's body weight, 5-10 mg per 1 kg of body weight. Mexidol intramuscularly is usually prescribed for severe diseases and conditions. Treatment with this medicine can be both intramuscular and intravenous, and by drip infusion.

Mexidol analogues

PRECISION MEDICINES SHALL BE PRESCRIBED TO THE PATIENT ONLY BY A PHYSICIAN. THIS INSTRUCTION IS FOR HEALTH PROFESSIONALS ONLY.

Registration number:
LSR-002063/07 dated 08/09/2007

Trade name of the drug:
Mexidol

Chemical rational name:
2-ethyl-6-methyl-3-hydroxypyridine succinate.

Dosage form:
coated tablets

Active substance:
ethylmethylhydroxypyridine succinate - 125 mg, excipients:
lactose monohydrate, sodium carboxymethyl cellulose (sodium carmellose), magnesium stearate, shell: Opadry II white (macrogol (polyethylene glycol), polyvinyl alcohol, talc, titanium dioxide).

Description:
Tablets are round, biconvex, film-coated, from white to white with a creamy tint.

Pharmacotherapeutic group:
antioxidant agent.

Mexidol is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (shock, hypoxia and ischemia, cerebral circulation disorders, intoxication with alcohol and antipsychotics (neuroleptics)).

The mechanism of action of Mexidol is due to its antioxidant, antihypoxant and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces the viscosity of the membrane, increases its fluidity. Mexidol modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps to preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission.

Mexidol increases the content of dopamine in the brain. It causes an increase in the compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, and stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a hypolipidemic effect, reduces the content of total cholesterol and low density lipoproteins.

The anti-stress effect is manifested in the normalization of post-stress behavior, somatovegetative disorders, the restoration of sleep-wake cycles, impaired learning and memory processes, and the reduction of dystrophic and morphological changes in various brain structures. Mexidol has a pronounced antitoxic effect in withdrawal symptoms.

It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disorders, vegetative functions, and is also able to relieve cognitive impairment caused by prolonged use of ethanol and its withdrawal. Under the influence of Mexidol, the effect of tranquilizers, neuroleptics, antidepressants, hypnotics and anticonvulsants is enhanced, which makes it possible to reduce their doses and reduce side effects.

Rapidly absorbed when taken orally. The maximum concentration at doses of 400 - 500 mg is 3.5 - 4.0 μg / ml. It is rapidly distributed in organs and tissues. The average retention time of the drug in the body when taken orally is 4.9 - 5.2 hours. It is metabolized in the liver by glucuronconjugation. 5 metabolites identified:

3-hydroxypyridine phosphate - is formed in the liver and, with the participation of alkaline phosphatase, breaks down into phosphoric acid and 3-hydroxypyridine; 2nd metabolite - pharmacologically active, formed in large quantities and found in the urine for 1 - 2 days after administration; 3rd - excreted in large quantities in the urine;

4th and 5th - glucuronconjugates. Th / 2 when taken orally - 2.0 - 2.6 hours. It is rapidly excreted in the urine mainly in the form of metabolites and in small quantities - unchanged. Most intensively excreted during the first 4 hours after taking the drug. Urinary excretion rates of unchanged drug and metabolites are subject to individual variability.

Consequences of acute disorders of cerebral circulation, including after transient ischemic attacks, in the subcompensation phase as preventive courses;

Encephalopathies of various origins (dyscirculatory, ismetabolic, post-traumatic, mixed);

Syndrome of vegetative dystonia;

Light cognitive disorders of atherosclerotic genesis;

Relief of the withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, post-abstinence disorders;

Asthenic conditions, as well as for the prevention of the development of somatic diseases under the influence of extreme factors and loads;

Impact of extreme (stress) factors.

Acute hepatic and / or renal failure, increased individual sensitivity to the drug. Due to insufficient knowledge of the action of the drug - children's age, pregnancy, breastfeeding.

Inside, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets). Duration of treatment - 2 - 6 weeks; for the relief of alcohol withdrawal - 5-7 days. Treatment is stopped gradually, reducing the dose within 2 to 3 days. Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase to obtain a therapeutic effect. The maximum daily dose is 800 mg (6 tablets).

Perhaps the appearance of individual adverse reactions: dyspeptic or dyspeptic nature, allergic reactions.

Mexidol is combined with all drugs used to treat somatic diseases. Enhances the effect of benzodiazepine drugs, antidepressants, anxiolytics, anticonvulsants and antiparkinsonian drugs. Reduces the toxic effects of ethyl alcohol.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Overdose may cause drowsiness.

Release form:
Film-coated tablets of 125 mg. 10 tablets in a blister pack made of PVC film and aluminum foil, or 90 tablets in a food grade plastic jar. 1,2,3,5 blister packs of 10 tablets each or 1 plastic jar of 90 tablets each with instructions for use in a pack.

Storage conditions:
List B. Store in a dry, dark place at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date:
3 years. Do not use after the expiration date indicated on the package.

Leave conditions:
On prescription

A: CJSC ZiO-Zdorovye, 142103, Moscow region, Podolsk, st. Zheleznodorozhnaya d. 2

B: CJSC ALSI-Pharma, CJSC ALSI Pharma, 129272, Moscow, Trifonovsky dead end, 3,

Organization accepting claims: OOO NPK Pharmasoft 115280, Moscow, st. Avtozavodskaya, 22

The popular new generation drug Mexidol, which belongs to the group of new generation antioxidants, is designed to stop destructive processes in the human body. Therefore, it is necessary to know how to take Mexidol tablets in order to restore and normalize metabolic processes in brain cells, so as not to harm the body.

The active active substance that is part of Mexidol is ethylmethylhydroxypyridine succinate 125 mg, as a result of which the following type of effect is exerted on the body:

• Improves tolerance to hypoxia;
• Improve mental abilities and concentration;
• The body is easier to tolerate stressful situations of a different nature;
• The state of nervousness is stopped;
• The toxic effect of alcohol on the body is reduced;
• Improves blood circulation in the brain;
• Improves sleep, appetite and general condition of the body.

Mexidol tablets, according to the instructions attached to the drug, are indicated for use to prevent cell oxidation and stabilize the structure of intracellular membranes. Regular use of this drug prevents platelets from sticking together, lowers blood cholesterol and prevents the development of degenerative processes, thereby slowing down the aging process.

Before use, you should consult your doctor at the time of contraindications for use. It is strictly forbidden to administer medicine to patients with the following diagnoses:

• Acute kidney failure
• Acute liver failure
• Hypersensitivity to the main ingredient of the drug or to auxiliary components

In case of an overdose of Mexidol, pain in the stomach and other disorders of the dyspeptic type may occur.

Mexidol usually easily affects the body without causing side effects. Possible negative manifestations may occur with individual intolerance. In this case, an allergic reaction to the administered drug may occur.

Failure to comply with the prescribed individual dosage leads to a dyspeptic response of the body to the administered drug.

• Anticonvulsant;
• Antioxidant;
• Nootropic;
• Anxiolytic;
• Antihypoxic;
• membrane-protective;
• Hypolipidemic.

• Hangover syndrome caused by prolonged use of alcoholic beverages. It is characterized by mental and neurological signs of manifestation;
• Neurosis and anxiety disorders;
• Serious disruptions in the blood flow of the brain;
• Head injury. Mexidol's testimony describes its effectiveness in relieving edema and relieving symptoms after injuries;
• Circulatory failure of the brain, which gradually progresses, for example, with;
• Vegetative vascular dystonia;
• Cognitive disorders, manifested in reaction inhibition, poor memory and a decrease in mental abilities;
• Myocardial infarction in the acute stage. In this case, Mexidol is prescribed in the first days after the incident, mainly in the form of droppers;
• Primary open-angle glaucoma;
• General intoxication of the body due to antipsychotic medications taken, for example, Haloperidol;
• Acute stage of the inflammatory process in the abdominal cavity, which is characterized by the release of pus, for example, pancreatitis and peritonitis;
• Epilepsy attacks;
• parkinsonian syndrome. In Parkinson's disease, the intensity of symptoms is significantly reduced.

• For the treatment of weakened blood flow in the brain, the drug is administered 1 time per day. The duration of the course is strictly individual;
• In case of failures in cerebral circulation, Mexidol is administered 2-3 times a day for 2 weeks;
• The course of therapy for cognitive disorders and anxiety is 14 days. The drug is used 1 time per day;
• With a hangover and drug addiction, 2-3 injections per day are usually given and the drug is canceled when the desired result is achieved;
• In the presence of pathological changes in the brain that have arisen due to injury or illness. In this case, a drip injection of the drug is used, and the duration of the course is approximately 14 days;
• Mexidol for epilepsy is administered 1 time per day for 2 weeks.

• Mexicor - effective for alcohol addiction, cheaper.
• Meksidant - helps with alcohol abuse, brain tissue injuries and VVD.
• Medomexi - chronic fatigue syndrome, VVD, damage to brain tissue and withdrawal.
• Mexiprim - stimulates metabolic processes and blood circulation, improves the functioning of the central nervous system.
• Cerecard is an analogue of Mexidol for cerebral and myocardial infarction, stroke, ischemia, atherosclerosis and vegetative-vascular dystonia.
• Mexifin - encephalopathy, extensive brain damage, alcoholism, atherosclerosis.
• Neurox - is prescribed for VVD, chronic fatigue syndrome, atherosclerosis and central nervous system problems. A big advantage is the cost is several times lower.
• Meksifan - used for acclimatization, disorders of the nervous system, chronic fatigue. Easily tolerated regardless of age, it is prescribed even for newborns.

• Impaired cognitive function;
• Disturbed systemic circulation of the cerebral cortex and not only;
• Nervous disorders with panic attacks, anxiety;
• Open-angle glaucoma;
• Insufficient nutrition of brain tissue.

Side effects

Side effects when taking Mexidol tablets are quite rare. Sometimes there is individual poor tolerance in the form of nausea and other dyspeptic complaints. Also, as with any drug, hypersensitivity reactions are possible on Mexidol.

Overdose

Mexidol tablets are safe to use, cases of overdose are extremely rare. In case of an overdose, general weakness or drowsiness may develop.

Mexidol is a new drug that has pharmacological effects at least at two levels: at the level of nerve cells and at the vascular level (which analogues do not have). At the same time, it has antioxidant and antihypoxic effects. In addition, this drug stabilizes cell membranes, has nootropic and anxiolytic effects.

The drug effectively helps, it is prescribed as a stress-protective drug, as well as for the prevention of many pathological conditions. The body becomes more resistant to adverse environmental conditions, at the same time, the proper level of development of adaptive reactions is ensured.

Mexidol helps to restore the cyclic mechanism of "sleep-wakefulness", improve the quality of sleep, increase tolerance to physical exertion, emotional stress and various conflict situations. The anxiolytic effect of the drug is manifested in a decrease in internal anxiety, anxiety and fear.

In addition, the drug has anticonvulsant activity and can be used to treat various forms of epilepsy (which analogues do not have, and therefore there is a need for a separate use of antiepileptic drugs).

What effect does Mexidol have on the body? The antihypoxic effect is manifested in an increase in the number of surviving experimental animals during the action of various types of hypoxia on their body.

Apparently, these effects are associated with an increase in anaerobic glycolysis and the amount of ATP, so indications for prescription include ischemic disorders.

Why does the drug include cognitive dysfunctions and disturbances in mnestic processes in the indications? It inhibits lipid peroxidation, helps modulate the activity of membrane-bound enzymes, improving the transport of mediators in axon terminals.

Mexidol helps to reduce increased blood viscosity, reduce the tendency to platelet aggregation, and improve the functioning of cerebral vessels. In addition, it helps to activate the metabolic processes of the brain tissue itself.

Pharmacokinetics

After administration, the drug is very quickly distributed, and also very quickly excreted from the body. After that, after 4 hours, the metabolites of the drug are no longer identified in the urine.

The mechanism of metabolism is carried out mainly in the liver with the formation of glucuronic conjugates, some of which are capable of exhibiting pharmacological activity.

The drug has significant pharmacological actions for the body and almost no

no adverse reactions and complications.

Healing effects
due to the action of the active substance of the drug on the central and autonomic nervous system and blood vessels.

The main properties of Mexidol:

• membrane stabilizer,
• inhibitor of the formation of free radicals,
• antihypoxant - (saturates the blood with oxygen),
• nootropic - (improves memory),
• tranquilizer - (relieves anxiety),
• increases the resistance of the body in conditions of hypoxia, ischemia, intoxication, has an anticonvulsant effect.

Free radicals destroy cell membranes or membranes, and then intracellular organelles, thereby triggering a mechanism for reducing immunity and developing diseases that are dangerous to health.

Mexidol as a strong antioxidant
, inhibits the formation of free radicals and protects cells from their destructive effects. Under the action of the drug, cell membranes are stabilized, the synthesis of nucleic acids and ATP is activated, blood parameters, microcirculation and rheological properties are improved, cholesterol is lowered.

Due to the restoration of blood circulation, blood supply and improvement of metabolic processes, dystrophic and morphological changes in all parts of the brain are reduced. In ischemic areas of the heart, the function of cardiomyocytes is preserved, myocardial contractility is normalized. The processes of excitation and inhibition are balanced, the cyclical processes of sleep and wakefulness are restored, the ability to learn and remember improves.

One of the most important properties of Mexidol is a strong antitoxic effect, which is especially evident in alcohol intoxication and poisoning.

In addition, the drug increases the production of the neurotransmitter dopamine, which actively affects mood, causes feelings of pleasure, increases physical activity, plays the role of an adaptogen in various stressful situations.

Mexidol is highly bioavailable, rapidly absorbed and distributed through the blood to organs and tissues. Decomposed in the liver into metabolites, excreted in 5-6 hours in the urine in the form of metabolites and in a small amount in an unchanged state. The half-life is from 2 to 3 hours.

Usually Mexidol does not cause side effects and this is possible mainly with improper use. In rare cases, after applying the solution, the following reactions of the body are observed:

• Nausea;
• sleep disorders;
• dry mouth;
• allergic manifestations.

A medication in the form of tablets sometimes provokes the development of such pathological phenomena:

• Pain in the abdomen;
• depression;
• Belching;
• Allergy;
• Nausea;
• stool disorders;
• Heartburn;
• Loss of appetite;
• Weakness.

Sometimes patients experience jumps in pressure (mostly a decrease), failures in coordination of movements and outbursts of emotions. Any form of the drug can influence the development of such pathological processes.

When is the remedy contraindicated?

The drug enhances the effect of tranquilizers and pain relievers. Affects obtaining an improved result after the introduction of anticonvulsant drugs. Reduces the impact on the body of toxic ethyl alcohol.

The drug is not recommended for injection in patients with allergic reactions, including those with a history of hypersensitivity to drug components. Contraindications include acute violations of the functional activity of the liver and kidneys.

There are no data on the effect on children, pregnant women and mothers who are breastfeeding, so the drug is most often not prescribed to these groups of patients. If there is no alternative, then it should be prescribed only when the expected benefit far outweighs the harm.

Side effects

A distinctive feature of Mexidol is its low toxicity, and therefore, the low incidence of side effects. Therefore, there are few contraindications to the drug.

Among the side effects that can be observed when using the drug in therapeutic concentrations, dry mouth, nausea and drowsiness are noted.

Overdose and additional instructions

Influence on the ability to drive vehicles and control mechanisms. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Probably, nausea and dryness of the mouth, drowsiness may appear. Allergic reactions are possible.

special instructions

In cases of individual hypersensitivity of patients to the components of the drug, allergic reactions are possible. Patients who drive cars need to be especially careful.

No features are observed with the parallel use of several drugs.

Mexidol is quite well combined with other drugs.

It tends to reduce the toxic effect of ethyl alcohol.

If necessary, it can be taken after drinking alcohol.

The drug is able to increase resistance to damaging influences (hypoxia, ischemia, shock, circulatory disorders of the brain, intoxication with alcoholic beverages or antipsychotics). The drug blocks lipid peroxidation, which can cause cell damage. It also modulates the activity of membrane enzymes, receptor complexes, which improves the functioning of brain cell membranes.

Mexidol is able to reduce platelet aggregation, thereby improving the rheological properties of blood. Stabilizes membranes of blood cells during hemolytic processes. It has a mild hypolipidemic effect.

In addition to the effects described above, Mexidol is able to stabilize disturbed vegetative processes, restore sleep, improve memory, and reduce morphological and degenerative disorders in brain structures. It has a good antitoxic effect in case of alcohol abuse, including withdrawal.

Reduces manifestations of acute alcohol intoxication, normalizes behavior, relieves cognitive impairment in chronic alcohol use. Mexidol is able to enhance the effect of tranquilizers, antidepressants, antipsychotics, hypnotics and anticonvulsants, which, when taken together, can help reduce drug dosages and reduce possible side effects.

Pharmacokinetic Mexidol tablets are well absorbed when taken orally. It is quickly distributed over organs and tissues, the average duration of action of Mexidol is about 4-5 hours. It is metabolized in the liver to 5 metabolites, pharmacologically active metabolites are determined in the urine up to 48 hours.

The half-life of oral administration is 2.5 hours. It is excreted in the urine, mainly in the form of metabolites, and also, slightly, unchanged. The most intensive excretion is noted in the first 4 hours after ingestion.

When taking Mexidol tablets, you should remember the special instructions:

• When used with antidepressants, benzodiazepines, anxiolytics, anticonvulsants, an increase in their effects should be expected. The toxic effect of ethanol, when used together, is reduced.
• When taking Mexidol, care should be taken when driving a car or performing potentially hazardous work that requires quick response and attention.

It is better not to prescribe Mexidol to patients with arterial hypertension or a crisis course of hypertension. For this category of persons, the drug is prescribed only after normalization of blood pressure and sedative therapy.

Mexidol is used with caution in persons whose work is related to driving vehicles or complex mechanisms, requiring increased concentration and attention.

An overdose of the drug is rare. Treatment is symptomatic, aimed at removing it from the body as soon as possible.

For treatment, dialysis detoxification methods are used, it is recommended to drink more fluids.

The drug reduces the toxic effect and side effects of ethyl alcohol on the body, and also potentiates the action of benzodiazepine anxiolytics and antiparkinsonian drugs for a long time.

The cost of the drug depends on the pharmacy network and dosage. On average, a package (tablets, 30 pcs) can be bought from 290 to 350 rubles. A large package (tablets, 50 pcs) can be bought a little more expensive - 400-450 rubles. The injection form of the drug (ampoules of a 5% solution of 2 ml, 10 pcs) will cost 490-550 rubles, ampoules (20 pcs of 5 ml) will cost around 1,500 rubles.

Mexidol is a highly effective drug with a very wide range of pharmacodynamic effects on the body. Side effects of the drug are minimal.

Due to its high efficiency (which its analogues do not have), the drug can be used to treat acute and chronic circulatory disorders of the brain. Injectable release forms (ampoules) allow you to start therapy immediately (if indicated).

When is the drug prescribed in tablets? Most often, after infusion therapy, patients are transferred to taking medication in tablet form (for maintenance therapy, as well as as a preventive measure), when adverse factors act on the body, after which their side effects decrease.

Excellent fights spasms, improves brain activity.

Exists in the form of tablets and solutions in ampoules. It has a wide spectrum of action, with a small number of side effects.

special instructions

Mexidol - contraindications

Ischemic heart disease is one of the indications for the use of Mexidol

• , but in combination with the interaction of other drugs.
• Negative changes in the blood circulation of the head in the acute stages of the course of the disease.
• With atherosclerosis of the capillaries of the brain (encephalopathy of the discirculatory type).
• Anxiety in neurotic diseases.
• Traumatic brain injury and its consequences.
• Acute phase of the heart (use from the first moments of the situation).
• Cognitive disorders of atherosclerotic etiology of mild form.
• Intoxication with antipsychotic drugs.

In addition to the main indications for the use of the drug, it is recommended to use it for the treatment of a symptom complex. The latter is provoked as a result of the negative impact on the nervous system of stressful situations and strong unrest.

Before buying a medicine, it is necessary to find out not only what it is from, but also in what cases this medicine cannot be used, namely:

• Intolerance to the composition of the drug;
• Liver failure;
• Malfunctions of the kidneys.

It is forbidden to use Mexidol during pregnancy and while breastfeeding. This phenomenon is associated with the fact that there is no exact data on the effect of the drug on the child.

Why is Mexidol prescribed? The drug is indicated for the treatment of:

1. Vegetovascular dystonia;
2. Alcohol and drug addiction;
3. Discirculatory encephalopathy;
4. Atherosclerotic brain pathologies;
5. Consequences of acute disorders of cerebral circulation, including after transient ischemic attacks, in the subcompensation phase as preventive courses;
6. Impact of extreme (stress) factors;
7. Conditions after acute intoxication with antipsychotics;
8. Anxiety disorders in neurotic and neurosis-like states;
9. Light traumatic brain injury, consequences of traumatic brain injury;
10. Acute pathologies of cerebral circulation.

1. Hypersensitivity to the drug;
2. Acute liver failure;

Instructions for use for the drug Mexidol states that there are much more indications for use than contraindications.

Contraindications

The number of contraindications is much less:

• too strong a person's susceptibility to the drug;
• a sharp change for the worse in the performance of the kidneys;
• a sharp change for the worse in the working capacity of the liver;
• contraindicated for children.

In cases of violation of the functional activity of the kidneys and liver, the use of the drug is prohibited.

This synthetic antioxidant is appropriate for internal use. Produced as a liquid solution for the purpose of injection and in the form of pills. If the doctor has prescribed Mexidol, the indications for use must be discussed in advance, to exclude cases of overdose, contraindications. In case of drug incompatibility, it is worth choosing a more gentle analogue with a mild effect on the focus of pathology.

The active substance of the chemical formula is ethylmethylhydroxypyridine succinate. The synthetic component improves tissue respiration, which is especially important for all types of hypoxia. In addition, it provides high-quality tissue nutrition, effectively fights the body's intoxication products. The therapeutic effect is almost instantaneous, especially if these are intramuscular injections in shock conditions.

Given the fact of drug interaction, it becomes obvious that not all patients can use this medication. If you are interested in Mexidol, the first thing to do is to study the contraindications. The manufacturer reports that taking pills and injections is not recommended if the clinical picture includes:

• renal failure;
• problems in the liver;
• hypersensitivity to synthetic components.

The Russian-made medicine is distinguished by a unique two-level action, so it will not be possible to briefly describe what Mexidol helps with. It affects the vessels and the state of nerve cells, producing the following effects:

• antioxidant;
• membrane-protective;
• antihypoxic;
• anticonvulsant;
• nootropic;
• hypolipidemic;
• anxiolytic.

These properties provide an extensive list of disorders in which a remedy is needed. Why Mexidol is prescribed in a particular case, the doctor determines - different problems cannot be solved in the same way, in each scheme the drug performs its function. For this reason, self-medication is prohibited - it can harm even if the recommended doses are observed. The main reasons for prescribing the drug are:

• and their consequences;
• vegetative dystonia;
• asthenic reaction;
• the result of an acute lack of cerebral blood supply;
• cognitive impairment of atherosclerotic nature;
• withdrawal syndrome;
• strong stress factors;
• ischemia;
• inflammation of the peritoneal organs;
• poisoning with psychotropic drugs;
• prevention of somatic disorders at high loads.

Due to the relative safety, the list of problems for which it is forbidden to use such treatment is surprisingly small. It includes:

• acute violations of renal and hepatic functions;
• allergy and intolerance to any component.

Whether Mexidol can be taken by children, pregnant and lactating mothers is decided in each case separately. Studies on this topic have not been conducted, so doctors avoid using the drug in these groups of people. In rare cases, the appointment may take place, but only if it is certain that the risk of negative consequences is significantly lower than the expected benefit.

In case of arterial hypertension and a crisis course, the use is carried out under strict control of the pressure level, the use of additional funds is not excluded. Also, caution when taking should be observed if it is necessary to drive a car and perform complex, high-precision work that requires a high concentration of attention. In case of manifestation of negative reactions, the dosage is reviewed or the drug is completely canceled.

Mexidol tablets are used very widely in neurological practice, in particular in the following conditions:

• • ONMK (hemorrhagic and stroke), as well as their consequences.
  • TBI ().
  • Abstinence.
  • Poisoning with antipsychotics.
  • Asthenia.
  • within asthenia.
  • Dizziness of various origins (with vascular diseases of the brain).

There are a number of contraindications to the use of the drug:

• Acute renal failure.
• Allergic reactions to the drug.
• Pediatric practice.
• Pregnancy and lactation.

It is also undesirable to use Mexidol in case of significant liver dysfunction.

The doctor can prescribe Mexidol therapy only after a complete examination of the patient, diagnosis and testing. The drug has a wide spectrum of action and is prescribed in such cases:

• After ischemic attacks in the body.
• In violation of blood circulation in the patient's brain.
• As a prophylaxis of ischemic stroke.
• After trauma to the head and skull.
• With the syndrome of vegetative dystonia.
• At the time of nervous disorders, with a feeling of anxiety.
• To combat withdrawal symptoms in alcoholism.
• It is prescribed after severe intoxication in the body.
• When the nervous system is damaged by severe stress.
• After strong psychological stress.
• At the time of myocardial infarction.
• With a purulent process in the abdomen.
• At the time of glaucoma of different stages.

1. If the patient has kidney problems, liver failure.
2. With increased sensitivity to the composition of the drug. The patient may be allergic to one of the components of Mexidol. In this case, you need to stop therapy with this drug.
3. Prohibited for children under 16 years of age.
4. Should not be taken by pregnant women.
5. Dangerous for the baby during breastfeeding. Substances of the drug can get through the milk to the child and greatly harm his health.

In case of individual intolerance to the remedy, you should immediately inform the doctor. He can prescribe analogues of Mexidol, which will help with illness and will not harm the body.

As a rule, "Mexidol" must be taken in the presence of the following conditions and diseases:

1. Various results of brain catastrophes (impaired microcirculation of the brain with damage to its tissue as a result of difficulty or complete cancellation of blood flow to its departments).
2. Head injury.
3. Diseases that are associated with damage to blood vessels.
4. Weakness.
5. Ischemia (local decrease in blood supply, in most cases due to a vascular factor, which leads to temporary dysfunction or damage to a tissue or organ).
6. Neurological diseases (a disease that develops as a result of damage to the brain and spinal cord, as well as peripheral nerve trunks and ganglia).
7. Lethargy.
8. General malaise.
9. Chronic stress (a serious illness that is detrimental to even more negative consequences: various mental disorders and serious ailments of internal organs).
10. Withdrawal syndrome in alcoholism (a consequence of the depletion of the resources of the whole organism in general and the liver in particular).
11. Vegetovascular dystonia (a complex of functional disorders, which is based on a violation of the regulation of vascular tone by the autonomic nervous system).

In each situation, the specialist, taking into account all the characteristics of the patient's body, develops a course of therapy, thanks to which the fastest effect can be achieved. In addition, the doctor will recommend how and at what time it is best to take Mexidol tablets.

Despite the huge range of actions, "Mexidol" can not be used by all people. There are situations in which the use of the drug will not bring the desired effect, for example:

1. Individual intolerance to substances.
2. “Interesting position” of a woman.
3. Breast-feeding.
4. Acute diseases of the liver and kidneys.

drug interaction

• Prevention of the oxidative process at the cellular level;
• Improving brain activity, including memory, learning and quick wits;
• Restoration of the cell membrane;
• Improving the nutrition of tissues with a lack of oxygen;
• Normalization of cholesterol levels;
• Removal of vasospasm;
• Eliminate anxiety and fear.

The drug Mexidol, due to its effect, helps to relieve intoxication in severe inflammation of the pancreas (pancreatitis). It can also be used for disruptions in cerebral blood flow and to relieve symptoms of a stroke. Mexidol is also taken with a headache caused by a lack of oxygen, since the drug eliminates this problem.

You can take Mexidol for any type of intoxication of the body. The drug reduces the effects of toxins, especially if the cause is taking antipsychotics and alcohol.

Long-term use of Mexidol with VVD has a good effect on the general well-being of the patient. Anxiety is relieved and brain activity is increased.

According to the instructions for use, Mexidol is characterized by a complex pharmacological action, has an antioxidant, adaptogenic, nootropic, membrane-stabilizing, cerebroprotective, anxiolytic, vegetotropic, anticonvulsant effect:

• Restores the functions and structure of cell membranes, modulates membrane-bound enzymes, improves the interconnection of brain structures and synoptic transmission;
• Improves the function of the immune system, inhibits platelet aggregation;
• It activates the synthesis of protein and nucleic acids inside the cells, accelerates the enzymatic reactions of the Krebs cycle and the utilization of glucose, promotes the synthesis of ATP and its accumulation inside the cells;
• Improves cerebral hemodynamics, including microcirculation, has a positive effect on blood flow, limits the area of ​​cerebral ischemia and stimulates reparative processes;
• Lowers the level of low density lipoproteins and cholesterol, promotes the regression of atherosclerotic changes in the vessels;
• It inhibits fat peroxidation, activates the antioxidant system, accelerates mitochondrial energy synthesis, improves cellular energy metabolism.

On the part of the digestive system: individual adverse reactions of a dyspeptic or dyspeptic nature may occur.

Others:
allergic reactions are possible.

Mexidol can be combined with all drugs used to treat somatic diseases. When used together, Mexidol enhances the effect of benzodiazepine derivatives, antidepressants, anxiolytics, antiparkinsonian and anticonvulsants. Mexidol reduces the toxic effect of ethyl alcohol.

If the patient has doubts about the use of any drug, it is best to consult with a specialist. Doctors say that "Mexidol" in tablets can be taken regardless of the time of eating.

The instructions for use for the Mexidol preparation do not indicate any interactions of the active substance with food or other drugs, which would lead to a decrease in the pharmacological action of the first or an increase in its toxic effect on the patient's body.

Now you know how to take Mexidol. Before or after meals, it doesn't matter. The drug can be taken at any time, regardless of the diet.

"Mexidol" is well tolerated by patients and does not irritate the mucous cavity of the gastrointestinal tract. Nausea may occur very rarely, but it is not associated with the peculiarities of use.

The key is only compliance with dosing - the daily concentration of the active substance is 250-500 milligrams, which is equal to three to four tablets per day, which must be divided into two or three doses.

Recently, an increasing number of people have to find out what Mexidol helps with. This is due to an increase in the number of vascular problems, in the treatment of which the drug is used. In addition, the possibility of its application in sports medicine is being considered.

Unlike other drugs that have a powerful effect, Mexidol almost does not cause side effects. While maintaining an adequate dosage problem, the following are possible:

• dry mouth;
• desire to sleep;
• nausea.

The volume of obtaining the substance depends on what Mexidol helps in a particular case, so you cannot change it yourself. This is due not so much to the possibility of getting a negative reaction, but to a decrease in effectiveness, which will make treatment more difficult. The low toxicity of the drug allows you to exceed the dose for a long time without a decrease in motor activity, a strong desire to sleep, deterioration in motor coordination or brain function. Because of this, there is a risk of not noticing problems and adjusting the therapeutic regimen late, which will lead to the need to revise it.

Before prescribing a medicine, the doctor studies its description, excludes contraindications, side effects, and incompatibility with other pharmacological groups as part of complex treatment. This will help to eliminate the deterioration of the general well-being of the patient, to speed up recovery. After prescribing the drug, keep in mind that Mexidol gives the following side effects:

• signs of dyspepsia of varying severity;
• local allergic reactions.

Mexidol, interacting with the body, exhibits properties that do not fight free radicals.

It has a wide scope of its action. This drug is prescribed in cases of poor oxygen supply to the tissues, or in cases of violation of this process.

This drug reduces the susceptibility of the body
to oxygen-dependent pathological conditions, improves memory, working capacity and concentration, reduces the harmful effects of alcohol on the body.

Mexidol is a drug that exhibits antioxidant properties.
.

Mexidol tablets and injections, as indicated by the instructions for use, contribute to the inhibition of free radical processes, lipid peroxidation.

It activates the antioxidant enzyme superoxide dismutase.
. It has a positive effect on the physicochemical properties of the biomembrane.

In the process of its impact on the human body, this drug acts as a substance that protects the membranes, prevents the occurrence of seizures, increases the body's resistance to the effects of negative factors on it and prevents the development of oxygen-dependent pathological conditions.

Improves blood circulation and reduces the ability of platelets to attract each other. It helps to reduce cholesterol levels.

Under the influence of this drug, the process of lipid peroxidation slows down, superoxide dismutase activity increases, the viscosity of the membrane decreases and, in turn, its fluidity decreases.

Due to its mechanisms of action, it has a small number of contraindications
and has a low level of toxicity.

Overdose

The doctor is obliged to tell the patient about possible side effects. They may not appear, but you still need to get information about them. Please note that side effects can greatly harm the body. Therefore, with a sharp deterioration in the condition, you should immediately inform the doctor. Here are the main side effects of Mexidol:

1. Nausea or vomiting.
2. Great dry mouth, constant feeling of thirst.
3. Allergy on the body.
4. Fatigue, constant sleepiness during the day.
5. Fear, anxiety and depression.
6. Emotional activity.
7. Hyperhidrosis.
8. Patient has frequent headaches.
9. Poor coordination, a person may even fall.
10. Overpressure.
11. Dizziness.

If side effects appear immediately, the doctor should urgently reduce the dose of the prescribed drug or, in extreme cases, stop therapy with this drug.

In ampoules

The second form of release of this drug is a solution for injection. If ordinary Mexidol is prescribed in this form, ampoules are also dispensed without a prescription. The release option is more effective, since the component - methylhydroxypyridine - immediately enters the systemic circulation, has a therapeutic effect, and gives a stable and lasting therapeutic effect. The drug has antioxidant, nootropic, antihypoxic and anxiolytic properties. Indications for use are as follows:

• malnutrition of brain tissue;
• impaired systemic circulation of the cerebral cortex and not only;
• nervous disorders with panic attacks, anxiety;
• impaired cognitive function;
• open angle glaucoma.

The drug Mexidol in ampoules according to the instructions is injected into the patient's body intramuscularly or intravenously. Single doses and the duration of the course is important to pre-specify with your doctor. A similar annotation of Mexidol reports that a single medication intake depends on the nature of the pathological process, the degree of neglect of the diagnosed disease. These may include the following rules:

1. Impaired cerebral circulation - 200-500 mg of medication / 14 days.
2. Traumatic brain injury - 500 mg / 14 days.
3. Circulatory failure in the cerebral cortex - 100-250 ml / 10 days.

The doctor may prescribe Mexidol injections intravenously or intramuscularly. The dose of the drug is prescribed by a specialist individually according to the diagnosis of the patient and the stage of the disease.
Sometimes it is necessary to dilute the agent with sodium chloride during injection, using 200 ml per ampoule.

Standard treatment begins with 100 mg of Mexidol 2-3 times a day. The doctor may gradually increase the dose if side effects are not observed. The maximum dose of the drug is 800 mg. Mexidol can be administered:

1. Jet. It is necessary to inject slowly, about 7 minutes.
2. Drip. Enter 50 drops in 1 minute.

Medication and driving, pregnancy and lactation use, pediatric use

For the treatment of children in pediatrics, the use of Mexidol is allowed only in case of craniocerebral injuries and in the treatment of purulent neuroinfections. Entering and monitoring the child's condition should be carried out by the attending physician.

The drug does not help expectant mothers to recover quickly, but can only harm the intrauterine development of the fetus, provoke extensive pathologies. Clinical studies of such categories of patients were not carried out, therefore Mexidol is not prescribed during pregnancy. In addition, the drug is contraindicated during lactation.

The drug does not help expectant mothers to recover quickly, but can only harm the intrauterine development of the fetus, provoke extensive pathologies. Clinical studies of such categories of patients were carried out, therefore Mexidol is not prescribed during pregnancy. In addition, the drug is contraindicated during lactation.

Price

The cost of the drug is available to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately the same price range.

It is important to read the instructions before buying. The price on the Internet is cheaper, real and positive recommendations from patients, high efficiency of the drug. If you buy a medicine at a pharmacy, the price depends on the city and region. No prescription required.

People usually find out how much drugs cost by phone or directly upon arrival at the pharmacy. The price of the drug is quite stable and depends only on the form of the drug:

• Tablets:
  • 30 pcs. - 370 rubles;
  • 50 pcs. - 225 rubles.
• Ampoules:
  • 2 ml 10 pcs. - 425 rubles;
  • 2 ml 50 pcs. - 1975 rubles;
  • 5 ml 5 pcs. - 425 rubles;
  • 5 ml 20 pcs. - 1600 rubles.

This is a Russian drug that is used for violations of the microcirculation of the brain. How to take "Mexidol"? In the morning or evening?

In the instructions for use for the drug, there is no information about the compatibility of the active ingredients of the drug with food. In this connection, "Mexidol" can be taken regardless of the food that is part of the daily menu.

In addition, among the positive aspects of the drug, the following can be distinguished:

• no nausea after use;
• good tolerance;
• antioxidant effect on the body.

Mexidol instructions for use. In this article, we will get acquainted with the instructions on how to use the drug Mexidol (Mexidol®) - what it helps from, its price and recommendations from customers. It is known from the instructions that this is Mexidol 125 mg film-coated tablets, Mexidol injections (in ampoules) of 5% of the drug for the treatment of encephalopathy, TBI and other brain disorders in adults, children and pregnancy.

Excipients:
lactose monohydrate - 97.5 mg, povidone - 25 mg, magnesium stearate - 2.5 mg.

The composition of the film shell:
Opadry II white 33G28435 - 7.5 mg (hypromellose - 3 mg, titanium dioxide - 1.875 mg, lactose monohydrate - 1.575 mg, polyethylene glycol (macrogol) - 0.6 mg, triacetin - 0.45 mg).

• 10 pieces. - cellular contour packaging (1) - packs of cardboard;
• 10 pieces. - cellular contour packings (2) - packs of cardboard;
• 10 pieces. - cellular contour packings (3) - packs of cardboard;
• 10 pieces. - cellular contour packings (4) - packs of cardboard;
• 10 pieces. - cellular contour packings (5) - packs of cardboard.

Mexidol (Mexidol®) - instructions for use

To optimize the functioning of the body, it is appropriate to additionally drink a course of prescribed medications. Mexidol is worth choosing if you need to influence the body's resources, maintain the functions and tone of internal systems, especially the central nervous system organs. Unauthorized use of the drug is strictly contraindicated.

The cost of the drug is available to almost all patients, and varies between 250-400 rubles per pack of tablets. The price of injections remains approximately the same price range. It is important to read the instructions before buying. The price on the Internet is cheaper, real reviews of high efficiency are positive. If you buy a medicine at a pharmacy, the price depends on the city and region. No prescription required.

Mexidol in tablets is released from pharmacies by prescription (appointment) of a doctor. It is found in almost all pharmacies. Average prices do not vary widely due to various factors and are:

• Packing 30 tablets 233-290 rubles.
• Packing 50 tablets 350-475 rubles.

Prices are approximate. An analysis of the drug market for 2019 has not yet been conducted.

Do not self-medicate to avoid tragic consequences. Before using Mexidol tablets, consult your doctor!

Mexidol is a drug that stops destructive processes in the body, restores tissues and nourishes them with useful substances. In order not to harm the body at the time of treatment, you need to know exactly how to take such a drug. We will talk about the action of Mexidol, describe its useful properties and contraindications.

The medicine includes the active substance ethylmethylhydroxypyridine, sodium metabisulfite, povidone, lactose, polyethylene glycol, titanium dioxide.

• Mexidol in tablets of 0.125 g - 50 pieces cost 410-460 rubles.
• Mexidol in tablets of 0.125 g - 30 tablets will cost 270-300 rubles.
• Mexidol in ampoules of 5 ml - 5 pieces cost -450-500 rubles.
• Mexidol in ampoules of 2 ml - 10 ampoules cost 460-510 rubles.

Composition of the drug and scope

There are tablet and ampoule versions of this medicine. Which drug Mexidol will be prescribed, the doctor chooses, based on the indications and ease of use. The difference between different forms of release lies in the concentration of the active substance and the presence of auxiliary components. The latter must be paid attention to if there have been cases of intolerance to any pharmaceutical products.

Mexidol - tablets

The main active ingredient is ethylmethylhydroxypyridine succinate, it contains 125 mg, other dosages are not yet produced. The composition of Mexidol tablets includes:

• lactose monohydrate;
• carmellose sodium;
• magnesium stearate.

The outer part is white or cream in color and consists of:

• talc;
• polyethylene glycol;
• titanium dioxide;
• polyvinyl alcohol.

Mexidol - ampoules

If the doctor has prescribed Mexidol, injections can be an alternative to taking pills. Variants with 250 and 100 mg of the main component are produced. At the same time, its concentration in 1 ml in both cases is the same - 50 mg. Also in the ampoules are present:

• sodium metabisulfi;
• water for injections.

The active substance of Mexidol is ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate). Available injection solution (50g/l) or tablets containing 125 mg. active substance. This is a domestic drug, one of the new generation of antioxidant drugs.

As excipients, Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 liter). Mexidol in tablets - excipients are magnesium stearate, sodium carboxymethylcellulose (otherwise - carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Mexidol - ampoules

Dosage and administration

Inside, 125 - 250 mg 3 times a day; the maximum daily dose is 800 mg (6 tablets). The duration of treatment is 2-6 weeks; for the relief of alcohol withdrawal - 5 - 7 days. Treatment is stopped gradually, reducing the dose within 2-3 days. Initial dose - 125 - 250 mg (1 - 2 tablets) 1 - 2 times a day with a gradual increase to obtain a therapeutic effect;

The dosage of the drug Mexidol depends on the disease in which it is used.

For the treatment of various diseases, there are standard dosages necessary to obtain a positive effect. There are the following norms for input depending on the disease:

1. acute stage: 5 days - intravenously, by drip at a dose of 100-150 mg, lasting up to 90 minutes. The next 9 days - intramuscularly. The substance should be administered 3 times a day with an interval of 8 hours, while the daily dose for therapy should be calculated from the norms of 6-9 mg per 1 kg of the patient's weight, but not more than 250 mg at a time.
2. Encephalopathy: 2 weeks of intravenous injection of 250-500 mg, 1-2 times every 24 hours. After the dosage is reduced to 100-250 mg per day for the next 14 days.
3. Changes in blood circulation in the brain of an acute nature: Introduction by drip into the cubital vein at a dose of up to 500 mg 3-4 times the dose, for 1.5-2 weeks. The next 2 weeks, the dosage should be reduced by 2 times.
4. Anxiety disorders and mild cognitive dysfunction: intramuscularly for 2-4 weeks, 150-300 mg per day.
5. Traumatic brain injury and its consequences: drip injection into a vein on the elbow two to four times a day, at a dose of 250-500 mg.
6. Intoxication with drugs of the antipsychotic type: up to two weeks, 200 to 500 mg intravenously is normal.

The dose of the drug, which is recommended for use during the day, in each case is calculated individually. It all depends on the age of the patient, the nature and stage of the disease. On average, the patient is recommended to take pomg of medication per day.

It is known that the use of many medicines on an empty stomach negatively affects the stomach and digestive system as a whole. To avoid this problem, Mexidol tablets should be taken after meals.

Mexidol tablets are taken orally, regardless of the meal. Doses are 1-2 tablets (125-250 mg) three times a day. The maximum dosage is 6 tablets (or 0.8 grams). The course of treatment is 1-2 months. Repeated courses are possible 2-3 times a year.

With alcohol withdrawal and poisoning with antipsychotics, the course of treatment can be equal to 7-10 days.

It is important to use Mexidol correctly for each disease:

• In case of skull injuries, Mexidol injections should be given for 2 weeks. You will have to inject 300 mg of the drug 3-4 times a day.
• If you need to improve blood circulation in the brain, use the drug for 10 days. Administer 300 mg once daily by drip. Then you can enter intramuscularly the agent three times a day, 100 mg each.
• In case of myocardial infarction, it is recommended to administer Mexidol intramuscularly for 14 days. In this case, you need to use complex treatment.
• Glaucoma requires treatment for at least 14 days. Enter intramuscularly 200 mg of Mexidol 2 times a day.
• At the time of alcohol withdrawal syndrome, it is necessary to inject the drug intravenously 2 times a day. The course of treatment is 7 days.
• With severe intoxication by other means, Mexidol should be administered intravenously at 100-200 mg. The course of treatment lasts at least 10 days.
• With pancreatitis, it is required to administer 400 mg of the drug 2 times a day. It is advisable to gradually reduce the dose until recovery.

If you take too many pills or give a large injection dose, complications can begin. Most often, a person begins severe drowsiness.
However, other side effects from the drug can become more complicated and cause great harm to health.

For impaired renal function

The prescription drug is contraindicated in acute renal failure.

Upon completion of the main stage of therapeutic treatment, the patient may be prescribed oral administration of the drug for prophylactic purposes. To find out how to drink Mexidol, you need to consult with your doctor.

And other not so widespread medications. Despite the fact that the drug is not cheap, in order to avoid unwanted side effects, it is not recommended to independently replace it with analog drugs with similar therapeutic characteristics.

Uncontrolled oral administration of Mexidol can provoke the following undesirable sensations: heartburn, nausea, headache, belching, general physical weakness, indigestion. In extremely rare cases, Mexidol can cause a decrease in blood pressure, impaired coordination of movement and emotional hyperreactivity.

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In case of circulatory disorders in the brain, an intravenous course of the drug is prescribed, which is administered for 10-14 days 2-4 times a day, in a volume not exceeding 500 mg, by the drip method. After that, within 2 weeks, the drug is administered by intramuscular injections, 2-3 times a day, 200-250 mg of the drug.

Relief from alcohol withdrawal

Mexidol instructions for use is an original drug with a nootropic effect, so it is often used to eliminate withdrawal symptoms and symptoms of ethyl alcohol poisoning. Many people believe that if you use the drug at the same time as alcohol, the effect of the latter can easily be neutralized. But this is just an erroneous assumption.

During the penetration of the substance into the body, the process of stopping the present pathology starts in it, while no protection is provided for the cells. Therefore, there is only one answer to the question of whether they can be used together: it is impossible, since there is no compatibility between the substances.

Disobedience in this regard can cause serious negative consequences in the form of nausea, vomiting, pain and dizziness. However, it is possible to use this drug as a single component in the phased elimination of alcohol dependence. Usually this technique helps to increase the effectiveness of therapy and the immediate elimination of disorders.

Thus, the drug is effective for eliminating numerous ailments and pathological phenomena, therefore, it will allow you to recover from any form of many diseases in just a short course. But before using the drug, it is recommended to consult a specialist.

To stop the alcohol withdrawal syndrome, Mexidol tablets are best taken within 7 days, as a continuation of treatment, after a course of intramuscular injections. The doctor independently, based on the individual characteristics of the patient's body, selects the dosage of the drug for the patient and prescribes a regimen for taking the tablets.

We all need protection in one way or another. External and internal. The body and mind are quite fragile and can be strengthened and maintained in many ways. Even medication.

If a person experiences negative effects (stress, shock, ischemia, intoxication, cerebrovascular accident, etc.), then the doctor may prescribe him Mexidol.

Figure 1 - Mexidol is a good helper in the fight against stress

The drug belongs to the group of heteroaromatic antioxidants and basically contains ethylmethylhydroxypyridine succinate, which in turn protects the lipids of cell membranes and reduces the level of free radicals in the body. This greatly expands the spectrum of pharmacological action. Mexidol has an antihypoxic (oxygenates the blood), anti-stress, anticonvulsant effect. It also has nootropic properties, prevents and reduces memory impairment, increases concentration and performance, and reduces the manifestation of alcohol intoxication. It restores the sleep-wake cycle, improves the metabolism of brain tissues and their blood supply, improves microcirculation and rheological properties of blood (its fluidity), reduces the rate of dystrophic and morphological changes in the brain. It has a pronounced therapeutic effect in the treatment of Parkinson's disease. Mexidol improves the functional state of the ischemic myocardium and the adaptive capabilities of the human body under the influence of various stress factors.

Mexidol also increases the content of dopamine in the brain, the so-called “hormone of joy”.

Indications

In neurology, Mexidol is used in the following cases:

• acute circulatory disorders of the brain and dyscirculatory encephalopathy (otherwise - atherosclerosis of the cerebral vessels);
• after transient ischemic attacks, in the phase of subcompensation as a preventive course;
• vegetovascular dystonia;
• cognitive problems of atherosclerotic origin (impaired speech, memory, attention, intelligence and other symptoms associated with the development of atherosclerosis).

In psychiatry, Mexidol is prescribed:

• to alleviate the withdrawal syndrome (otherwise - breaking) with alcohol and drug addiction;
• with intoxication with neuroleptics (drugs intended for the treatment of psychosis);
• to facilitate the impact of extreme (stress) factors;
• in anxiety disorders in neurotic and neurosis-like states.

Mexidol is also used in acute purulent-inflammatory processes of the peritoneum (necrotizing pancreatitis and peritonitis) as part of a complex of therapeutic methods of treatment.

Contraindications

The drug can not be used for:

• hypersensitivity to the drug;
• acute liver failure;
• acute renal failure.

Side effects

Figure 2 - One of the side effects after taking Mexidol may be nausea

Despite the positive reaction of the body to taking Mexidol and its low toxicity, the drug still has side effects.

• from the side of the cardiovascular system: increased blood pressure, lowering blood pressure;
• from the nervous system: drowsiness, impaired sleep, anxiety, emotional reactivity, headache, impaired coordination;
• from the gastrointestinal tract: nausea, dryness of the oral mucosa;
• from the immune system: allergic reactions, including hyperemia, skin rash, itching;
• others: distal hyperhidrosis.

How to take Mexidol

Mexidol in tablet form is taken orally. The tablet is not chewed or divided in half. Drink it with plenty of water. Eating does not have any effect on the activity of the drug, so you can take Mexidol before, during or after a meal.

The injection form is used for intramuscular injections or for intravenous infusions (stream or drip). Before giving an injection, the drug is diluted in a 0.9% sodium chloride solution. Jet injected slowly over 5 - 7 minutes, drip - at a rate of 40 - 60 drops per minute. The maximum daily dose for tablets is 800 mg, for injections - 1200 mg. Course therapy is canceled gradually, after achieving a stable clinical and laboratory effect.

Figure 3 - Mexidol solution for intravenous administration

Please note that after taking Mexidol, drowsiness may occur, so you should be careful while driving, as well as when engaging in other potentially hazardous activities.

Disease	Course duration	Dosage*
Acute cerebrovascular accident (ACV)	Initially within 10-14 days	200-500 mg (in / in drip) from 2 to 4 times / day, then another 14 days 200-250 mg (in / m) several times / day
Encephalopathy	Initially within 2 weeks
Mild cognitive impairment	Course from 2 weeks to a month	100-300 mg/day (IM)
withdrawal syndrome	5 to 7 days	200-250 mg / day (in / in drip or / m) 2 - 3 times / day
Poisoning with neuroleptics	Course in 7-14 days	200 to 500 mg/day (iv)
Acute edematous (interstitial) pancreatitis		200-500 mg (in/in drip and/m) 3 times/day
Necrotizing pancreatitis (mild)		100-300 mg/day (in/in drip and/m 3 times/day
Necrotizing pancreatitis (moderate)		200 mg (iv) 3 times / day
Necrotizing pancreatitis (severe)		In a pulse dosage of 800 mg on the first day, with a double administration regimen. Then 200 - 500 mg 2 times / day with a gradual decrease in the daily dose.
Necrotizing pancreatitis (extremely severe)
Open-angle glaucoma of various stages	Course 14 days	In / m 100 - 300 mg / day, 1 - 3 times / day
Traumatic brain injury and consequences of traumatic brain injury	Within 10 -15 days	In / in drip 200 - 500 mg 2 - 4 times / day

*When taking tablets. In parentheses, the method of administering an injection of Mexidol at the same dosage is indicated.

The duration of the course of therapy for patients with coronary heart disease is at least 1.5-2 months. Repeated courses (on the recommendation of a doctor) are preferably carried out in the spring and autumn periods.

In acute myocardial infarction, as part of complex therapy, it is administered intravenously (first 5 days) and intramuscularly (next 9 days) for 14 days against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic agents according to indications.

Mexidol during pregnancy and lactation

Often, drugs for pregnant women and nursing mothers are prescribed with caution, as well as in cases where the benefit to the mother outweighs the risks to the fetus and newborn. With Mexidol the same story. There are no statistically significant studies of the use of the drug in pregnant women, nursing mothers and children. That is, clinical studies that could be relied upon, alas, do not exist. Therefore, the drug is either prescribed as a last resort, or it is not recommended to use it.

Figure 4 - Mexidol during pregnancy is prescribed with caution

As for children, the use of Mexidol in pediatrics is indicated for the treatment of purulent neuroinfections, traumatic brain injuries, as well as for first aid in case of childhood traumatic brain injuries (100 mg once).

Interaction

Mexidol has shown itself to be a drug that has high compatibility with other drugs, including those used to treat somatic diseases. But it is worth noting that Mexidol is able to enhance the effect of benzodiazepines, carbamazepine and drugs for the treatment of Parkinson's disease, analgesics, tranquilizers, antipsychotics and antidepressants, as well as substances with hypnotic and anticonvulsant effects. This allows you to reduce their doses and remove most of the side effects.

Mexidol reduces the toxicity of ethyl alcohol. This useful property is used in the treatment of alcohol withdrawal syndrome.

Mexidol and alcohol

As mentioned above, Mexidol is used as a therapy for getting rid of alcohol dependence. The drug reduces the toxic effect of alcohol, removes it from the body. But this does not mean that you can drink alcohol while taking Mexidol. The active substance of Mexidol, penetrating into the tissues of the liver and brain, only stops the signs of intoxication, but does not protect the cells themselves. That is, the effect of alcohol consumed by Mexidol is not neutralized and harms the body.

Analogues

The pharmaceutical market offers not only Mexidol, but also its analogues. Preparations differ in the main substance (although Mexidol's synonyms contain the same ethylmethylhydroxypyridine succinate), auxiliary components, manufacturers, and the quality of purification of the raw materials used. That is why, after consulting a doctor in pharmacies, you can choose drugs that are similar in their therapeutic effect to Mexidol tablets, but are selected for a specific clinical picture.

Picture 5 - Replacement of the drug with an analogue must be agreed with the attending physician!

Kalinov Yury Dmitrievich

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Mexidol or picamilon which is better

The exact answer can only be given by the doctor who treats the patient. If two drugs turned out to be prescribed, we can safely say: both are necessary in treatment.

Advantages of Mexidol:

• effective in cerebral ischemia;
• normalizes the condition after concussion;
• help with acute, chronic intoxication, alcoholism;
• improves memory, learning ability;
• reduces stress levels.

The benefits of Picamilon are due to its effect on blood vessels:

• proven efficacy in vegetovascular dystonia (VVD);
• indispensable in the complex treatment of atherosclerosis;
• treats disorders of cerebral circulation of various nature, dizziness;
• eliminates excessive emotionality, tearfulness.

Mexidol application

Before taking Mexidol, it is necessary to obtain a doctor's permission. Only a specialist is able to make a decision on the appointment of the drug. He develops an individual treatment regimen indicating the dosage, the number of doses per day and the duration of the medication. It all depends on the type of pathology and the condition of the patient.

So, in the diagnosis of ischemic acute brain damage, the drug must be administered as a solution for injection intravenously. Only after stabilization of the patient's condition, therapy is continued with the help of Mexidol tablets. The use of lower dosages in this case ensures a high therapeutic effect.

How to take Mexidol for treatment?

How to take Mexidol tablets, how many times a day and for how long - the doctor determines.

In doing so, he is guided by the following:

• type of disease;
• patient's age;
• stage of pathology;
• severity of the clinical picture.

When asked about how to take Mexidol, before or after meals, doctors answer that this parameter does not matter. Dosing plays an important role.

Each case is individual, but often doctors adhere to the following treatment regimen:

• 125-250 mg of the drug 3 times a day;
• the maximum daily dose of the drug is 800 mg (6 tablets).
• the abolition of the drug is carried out by gradually reducing its dosage within 2-3 days;
• repeated courses are carried out on the recommendation of a doctor after some time.

How to take Mexidol for prevention?

Before taking Mexidol tablets for prevention, you should consult your doctor regarding the appropriateness of such therapeutic measures. The drug may be useful for patients with dyscirculatory encephalopathy, when the disease is in the compensation phase. In such cases, the drug in tablet form begins to be used after the end of the course of its intravenous administration. It lasts about 10 days.

Mexidol tablets (dosage of 125 mg) are taken 3 times a day. Duration of admission - 2-6 days. If initially Mexidol tablets are used for a course of prevention, doctors choose the following scheme: 125 mg of the drug 3 times a day, 4-6 weeks in a row. Similarly, treatment of vertebrobasilar insufficiency, which is a consequence of osteochondrosis of the cervical spine, is carried out.

How long can I take Mexidol tablets?

Treatment regimens and duration of therapy are determined by the nature of the pathology and depend on the specific situation. The pharmacological form of Mexidol is also of decisive importance. So, when using the drug parenterally (intravenously or intramuscularly), the course of treatment lasts no more than 10 days. The tablet form of Mexidol is prescribed for 1-1.5 months. However, in some cases, the drug may be prescribed for up to 6 months of use. How long to take Mexidol in a particular case is determined by the doctor.

Mexidol analogues

When prescribing Mexidol, which injections or tablets are better in a particular case, doctors determine according to the clinical picture. In acute disorders requiring quick, emergency care and the need for an early onset of effect, the drug is used in the form of a solution. The medicine is administered intravenously or intramuscularly.

In some cases, in the absence of the effect of the use of Mexidol, it becomes necessary to select a similar drug.

Among drugs with a similar mechanism of action and therapeutic effect:

• Neurox;
• Cerecard;
• Hypoxen;
• Riluzole;
• Vitagamma;
• Emoxybel.

Mildronate or Mexidol - which is better?

When choosing a medicine for cerebral vessels, doctors can replace Mexidol with Mildronate. This drug significantly improves cerebral circulation, so it is more often used if necessary to prevent strokes. It does not affect cell membranes, does not have anticonvulsant and sedative properties, therefore Mexidol is used for these symptoms.

Neurox or Mexidol - which is better?

Thinking about how to replace Mexidol in case of cerebrovascular accident, brain damage, doctors resort to the help of Neurox. The composition of this drug contains the same active substance, which has a pronounced metabolic and antioxidant effect. A distinctive feature is the release form: Neurox is available only in ampoules and does not have a tablet form. Because of this feature, the need to replace Mexidol may arise in cases where this drug in the form for injection does not bring the expected result.

Cytoflavin or Mexidol - which is better?

In cases where Mexidol cannot be used, the analogue of this drug, Cytoflavin, becomes the main drug in the course of therapy. It copes well not only with protecting cells, but also contributes to the active restoration of brain functions after a stroke. Cytoflavin copes well with the chronic form of cerebrovascular pathology, the consequences of this disease.

The advantage of Cytoflavin is that it has fewer contraindications. The medicine can be used to treat patients with liver failure. It should be noted that Cytoflavin contains a larger amount of active ingredient compared to Mexidol tablets. This accelerates the onset of the desired therapeutic effect. Treatment with Cytoflavin lasts no more than 25 days, while Mexidol has to be used for at least a month.

What are Mexidol tablets

The drug Mexidol is used by doctors when it is necessary to restore oxygen metabolism. It performs a kind of protection of cell membranes from the effects of free radicals that can destroy them.

Conducted studies have shown the high efficiency of the drug, which:

• improves memory process;
• reduces intoxication of an organism at hit of toxins.

Features of the treatment of VVD

The manifestation of VVD symptoms can begin in stressful situations and even at a time when nothing portends danger. As symptoms may occur: headaches, neurological disorders, weakness of the body as a whole, the occurrence of swelling, disruptions in the activity of the respiratory system.

Not infrequently, VVD is accompanied by mental disorders, so experts have focused on the treatment of the disease using an antioxidant drug. One of these is Mexidol.

Antioxidants are substances whose effect is due to the protection of cells from oxidative processes occurring in the cells of the human body, due to various reasons.

When studying VVD diseases, scientists noted that quite often people experience disturbances in the functioning of the human brain. Scientific studies have been carried out. According to their results, it was concluded that the use of the drug Mexidol leads to an increase in the labor intensity of a person, and the fatigue syndrome in VVD is eliminated. This leads to the restoration of the normal functioning of the nervous system in VVD.

The use of Mexidol in VVD should be carried out only as directed by the attending physician. In the case of independent use, serious problems can arise.

Mexidol injections with Picamilon, is it possible to combine

Drugs are much more effective when used parenterally, doctors often prescribe injections to patients. Will I have to give up injections to use Picamilon and Mexidol together?

1. It is possible to use Picamilon with Mexidol in the form of injections, only different syringes should be used. It is undesirable for two drugs to be mixed due to their different chemical nature. Such clinical trials have never been conducted.
2. Make sure that Picamilon and Mexidol are injected into different parts of the body. When administered intramuscularly - in both buttocks, in the buttock and thigh. This treatment condition helps prevent unwanted effects of drug combinations.
3. Divide the use of two drugs by time, it is desirable to introduce Picamilon first. It has a vasodilating effect, is able to prepare the body for better absorption of Mexidol into the bloodstream. After using Picamilon in an injection, the effect of Mexidol is longer and more pronounced.

Joint injections of Picamilon and Mexidol have the same advantages as taking in the form of tablets. Additional benefits of injections:

• rapid onset of action (10-15 minutes after injections);
• better absorbed by the body;
• no side effects on the gastrointestinal tract;
• more pronounced, lasting effect.

Hypertension why blood pressure rises at night

Have you struggled with HYPERTENSION for many years without success?

Head of the Institute: “You will be amazed at how easy it is to cure hypertension by taking it every day…

Why does blood pressure rise at night? This question is relevant, since hypertension has recently begun to be observed more often in a younger population.

It is important to know that in a healthy person, daytime pressure should be higher than nighttime. The reason is that in the daytime, the pace of life, stress and physical activity make all organs, including the heart, work faster, because the pressure rises.

At night, the body relaxes, rests and the work of almost all organs slows down, so the pressure decreases. If there is no decrease or, on the contrary, it has risen, this indicates a serious pathology. Therefore, you need to figure out why the pressure rises at night and what to do about it.

Possible reasons

First of all, it is worth analyzing your lifestyle, nutrition and habits, because when the pressure rises at night, it screams about an already existing problem, and it needs to be found.

1. Drinking plenty of water during the day is good, but it is a very bad habit to drink large amounts of liquid at night. When a person goes to bed, his kidneys also need to rest. But water, drunk at night, gives extra work to the kidneys. If you drink a few cups of tea late in the evening, then in addition to the liquid, substances that stimulate the body enter the body. Instead of resting, it “turns on”, and the pressure rises.

1. At risk are those who like to eat tightly before bed. Scientists have noticed that a late dinner does not contribute to lowering the pressure at night, but rather the opposite. After observing a group of hypertensive patients for some time, experts came to the conclusion that the refusal of dinner brought the nighttime pressure indicators back to normal. If it is impossible to put yourself on such a diet, make sure that at least 3 hours pass from the last meal to sleep.
2. Alcohol abuse does not benefit anyone, but if you drink it in the evening, it will lead to increased pressure at night. The later a person drinks, the more likely the increase in blood pressure increases. To avoid this, do not drink in the evening, at least after 6 o'clock. It is worth considering: the breakdown of alcohol, even in healthy people, leads to brain spasms, which also causes symptoms of hypertension. Therefore, drinking the day before can lead not only to a severe hangover, but also to high blood pressure.

Dosage

Taken orally in a single dose of 125 to 250 mg three times a day	It is administered intramuscularly or intravenously (by jet injection for 5-7 minutes or by drip injection of 40-60 drops per 1 minute). For infusion administration, Mexidol is diluted in 0.9% NaCl solution.
The initial dose is prescribed from 125 or 250 mg once or twice a day, gradually increasing to therapeutic.	Acute violations of cerebral hemodynamics: 10-14 days, 200-500 mg intravenously by drip 2-4 times / day, the next 2 weeks: 200-250 mg intramuscularly twice or thrice a day.
Treatment is stopped with a gradual decrease in the dose of the drug within 2 days.	TBI and consequences of TBI: 10-15 days by intravenous drip infusion of 200-500 mg 2 to 4 times a day.
The maximum daily dose is 800 mg.	Dyscirculatory encephalopathy: 14 days intravenously by jet or drip injection of 200-500 mg once or twice a day, the next 2 weeks i / m at 100-250 mg / day.
The duration of treatment is from 5 days to 8 weeks.	Mild cognitive dysfunction and anxiety disorders: 14-30 days intramuscularly at a dosage of 100-300 mg / day.
Repeated courses are recommended in the spring and autumn periods.	Acute myocardial infarction: the first 5 days intravenously, 100-150 ml intravenously for 30-90 minutes, the next 9 days - intramuscularly. The introduction of Mexidol (in / in and / m) is performed 3 times / day every 8 hours at the rate of a daily therapeutic dose of 6-9 mg / kg of body weight. The maximum single dose is 250 mg, the daily dose is 800 mg.
	Open-angle glaucoma: 14 days intramuscularly at a dose of 100-300 mg / day 1-3 times a day.
Withdrawal alcohol syndrome: 5-7 days by intravenous drip or intramuscular injection at a dose of 200-500 mg twice or thrice a day.
Acute intoxication with antipsychotics: 7-14 days intravenously at 200-500 mg / day.
Acute edematous pancreatitis: intravenously by drip and intramuscularly at a dose of 200-500 mg three times a day.
Necrotizing pancreatitis of mild severity: intravenous drip and intramuscularly at a dosage of 100-200 mg three times a day. Moderate severity: intravenous drip method of administration at a dose of 200 mg three times a day.

Mexidol contraindications and side effects

Having found out what Mexidol tablets consist of, indications for the use of this medication, it should be noted that there are some restrictions on their use. Before going on sale and mass production, each drug undergoes laboratory and clinical studies. Their goal is to identify possible side effects and pathologies - conditions in which the use of a medicine can harm the patient's health, worsen his well-being.

Similar studies were carried out for Mexidol. According to the results of the study, experts compiled a list of side effects and contraindications. To determine whether Mexidol can be used by a patient in a particular case, the doctor examines the patient and carefully studies the medical history.

Mexidol - contraindications

Like other drugs, the drug Mexidol has some contraindications. If available, Mexidol tablets are replaced with a similar drug, with a similar effect, but without contraindications.

According to the instructions for the drug, Mexidol is forbidden to use in the following cases:

• children under the age of 12;
• the period of bearing a baby and breastfeeding;
• acute renal failure;
• liver failure;
• individual intolerance to the components of the drug.

Doctors pay special attention to prescribing the drug to patients with high blood pressure, accompanied by hypertensive crises. It is undesirable to use the drug for the treatment of patients with hypotension (predisposition to low blood pressure)

Do this only under the supervision of a doctor.

Mexidol - side effects

When a patient takes Mexidol tablets in strict accordance with medical prescriptions, side effects develop less frequently. However, they cannot be completely excluded. In general, doctors say that Mexidol tablets are well tolerated by patients, complaints from them are rare.

Mexidol and Picamilon can be taken together

After consulting with a number of neurologists, we received similar answers, which can be reduced to one:

“Mexidol and Picamilon perfectly complement each other's effect, they can be taken simultaneously to enhance the effect on the patient's body. Picamilon dilates blood vessels, increases their permeability, more blood with nutrients and oxygen begins to flow to the brain tissue. If Mexidol is taken together, then it will reach the nerve cells faster, will have a more significant and lasting therapeutic effect than in the absence of Picamilon.
Specialists prescribe both drugs in a complex if the patient has both disorders of the central nervous system and blood circulation. Such symptoms are typical for the elderly, debilitated individuals with chronic diagnoses.
Due to the antioxidant effect of Mexidol and the vasodilating effect of Picamilon, the level of brain hypoxia decreases, because more oxygen enters it, and its needs decrease. The combination of Mexidol and Picamilon has the best effect. Combined use is useful in that the therapeutic effect is achieved at lower doses, short treatment periods.

This is important for patients suffering from diseases of the liver, excretory system.

Treatment of discirculatory encephalopathy causes, clinical signs, treatment

At the first stage of the disease, the neurological deficit affects only certain aspects of mental activity. This is expressed in the appearance of memory or behavioral disorders. In the future, memory loss gradually increases, intelligence decreases. In addition, the decrease in the affective sphere is also increasing, which is characteristic of the chronic phase of the psychoorganic process and is almost indistinguishable from vascular dementia.

Especially with this disease, complex mental processes that are associated with the processing of information suffer. In patients with a diagnosis of dyscirculatory encephalopathy of mixed genesis, there is a disorder in the program of actions, gait, orientation in time, place, and even one's own personality. There may be paroxysmal disorders of consciousness, counting, writing, generalized thinking.

In addition to the slowly progressive course of dyscirculatory encephalopathy, there is also a "galloping" and remitting with the presence of periodic disruptions and compensations. Usually, stressful situations, infections, injuries, intoxications cause a relapse of this disease.

Clinical signs

As a rule, functional neurodynamic symptoms appear in the early stages of the disease. In the future, there is a progression of an organic neuropsychic defect with a disorder of memory, motivations, drives, emotions.

The patient's complaints include fatigue, irritability, absent-mindedness, memory loss, headaches during mental or physical stress. Symptoms of the disease increase in the second half of the day, after a sleepless night, etc. It should be noted that the patient's own assessment of the decrease in his working capacity does not coincide with the positive characteristics of others. Asthenic syndrome can be regressed with prolonged rest, treatment, changes in the situation at home or at work, and the regression can last a relatively long time.

At the second stage of the disease, the neuropsychic defect deepens. The patient is not sufficiently critical of his condition, overestimates his capabilities and performance. The transition from self-doubt to attempts to find "objective reasons" in one's failures is also characteristic. In addition, such patients have a narrowing of the volume of perception, rapid exhaustion, refusal to perform tasks and their replacement with lighter primitive forms.

Treatment of dyscirculatory encephalopathy

Among the main directions of drug therapy for a slowly progressive type of cerebrovascular insufficiency, there are several separate stages. Therapeutic measures are aimed at increasing cerebral blood flow and metabolism of brain tissues, stopping neurasthenic symptoms, normalizing sleep, limiting mental and physical stress, eliminating stressful situations, normalizing rest and work conditions.

As for medications, nicotinic acid preparations, nootropic drugs, and calcium channel blockers are widely used in the treatment of dyscirculatory encephalopathy.

In addition, the patient needs psychotherapeutic conversations, autogenic training, selection of a rational diet, moderate physical activity, outdoor walks, and physical labor. With an increase in symptoms, a consultation with a neuropsychiatrist is necessary.

Description of Mexidol

It is rather problematic to determine the exact classification of Mexidol. The fact is that this tool is able to have various therapeutic effects and affect different systems of the human body. The drug Mexidol belongs to several pharmacological groups. It can be defined as medicines that have a positive effect on the cardiovascular system in VVD. Mexidol also refers to medicines that act mainly on the cerebral vascular system. At the same time, Mexidol is one of the types of antioxidants.

There are several options for the impact of Mexidol on the human body. Due to the action of the active substance of the drug, which is ethylmethylhydroxypyridine succinate, there is a positive effect on the manifestation of such effects:

• antioxidant;
• antihypoxic;
• neuroprotective.

Mexidol is a highly effective antioxidant. From which we can conclude that when it is taken, lipid peroxidation is blocked, as a result, cell membranes are normalized. The drug Mexidol is able to protect the cells of the internal organs in VVD. The positive effect of the drug is aimed at protecting the cells of the liver and brain.

The antihypoxic effect is understood as an increase in the body's ability to be stable with a low oxygen content in the blood as a result of the use of Mexidol.

This is very important in the treatment of VVD accompanied by hypoxia. A short-term decrease in the need for oxygen, contributes to an increase in the stress resistance of the human body

The hypolipidemic effect of Mexidol is an excellent prevention of atherosclerosis in VVD. It is noted that this drug to some extent contributes to blood thinning in VVD.

The manifestation of a slight anxiolytic effect of Mexidol contributes to the additional suppression of emerging stress conditions in VVD. Experts note that when taking Mexidol in combination with tranquilizers, antipsychotics, antidepressants, an increase in the action of all drugs for the treatment of VVD is seen.

This is a Russian drug that is used for violations of the microcirculation of the brain. How to take "Mexidol"? In the morning or evening?

In the instructions for use for the drug, there is no information about the compatibility of the active ingredients of the drug with food. In this connection, "Mexidol" can be taken regardless of the food that is part of the daily menu.

In addition, among the positive aspects of the drug, the following can be distinguished:

• no nausea after use;
• good tolerance;
• antioxidant effect on the body.

Indications

As a rule, "Mexidol" must be taken in the presence of the following conditions and diseases:

1. Various results of brain catastrophes (impaired microcirculation of the brain with damage to its tissue as a result of difficulty or complete cancellation of blood flow to its departments).
2. Head injury.
3. Diseases that are associated with damage to blood vessels.
4. Weakness.
5. Ischemia (local decrease in blood supply, in most cases due to a vascular factor, which leads to temporary dysfunction or damage to a tissue or organ).
6. Neurological diseases (a disease that develops as a result of damage to the brain and spinal cord, as well as peripheral nerve trunks and ganglia).
7. Lethargy.
8. General malaise.
9. Chronic stress (a serious illness that is detrimental to even more negative consequences: various mental disorders and serious ailments of internal organs).
10. Withdrawal syndrome in alcoholism (a consequence of the depletion of the resources of the whole organism in general and the liver in particular).
11. Vegetovascular dystonia (a complex of functional disorders, which is based on a violation of the regulation of vascular tone by the autonomic nervous system).

In each situation, the specialist, taking into account all the characteristics of the patient's body, develops a course of therapy, thanks to which the fastest effect can be achieved. In addition, the doctor will recommend how and at what time it is best to take Mexidol tablets.

Do you take the drug before or after meals? Read more about this.

Contraindications

Despite the huge range of actions, "Mexidol" can not be used by all people. There are situations in which the use of the drug will not bring the desired effect, for example:

1. Individual intolerance to substances.
2. "Interesting position" of a woman.
3. Breast-feeding.
4. Acute diseases of the liver and kidneys.

Peculiarities

How to take "Mexidol", before meals or after meals? Food does not affect the absorption of the drug. The drug belongs to antioxidant drugs, as a rule, it is used for violation of the functioning of the brain.

If you read the instructions for using "Mexidol" in more detail, then it indicates only the dosages that can be taken per day, as well as the duration of therapy with this medication.

So how to take "Mexidol", before or after a meal? The use of the drug is not tied to food intake, that is, a person can take it when it is convenient for him. The main rule is compliance with the dosage and sequence of administration.

Interaction

If the patient has doubts about the use of any drug, it is best to consult with a specialist. Doctors say that "Mexidol" in tablets can be taken regardless of the time of eating.

The instructions for use for the Mexidol preparation do not indicate any interactions of the active substance with food or other drugs, which would lead to a decrease in the pharmacological action of the first or an increase in its toxic effect on the patient's body.

Now you know how to take Mexidol. Before or after food, it doesn't matter. The drug can be taken at any time, regardless of the diet.

"Mexidol" is well tolerated by patients and does not irritate the mucous membrane of the gastrointestinal tract. Nausea may occur very rarely, but it is not associated with the peculiarities of use.

Only adherence to dosing is considered the key - the daily concentration of the active substance is 250-500 milligrams, which is equal to three to four tablets per day, which must be divided into two or three doses.