Add to favorites

Properties of polyoxidonium. Polyoxidonium ® (Polyoxidonium ®) instructions for use

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

P N002935/04

Trade name:

Polyoxidonium ®

International non-proprietary name:

Azoximer bromide (Azoximeri bromidum)

Chemical Name:

copolymer of N-oxide of 1,4-ethylenepiperazine and (N-carboxymethyl)-

1,4-ethylenepiperazinium bromide

Dosage form:

pills

Composition per tablet:

Active ingredient: Azoximer bromide - 12 mg;

Excipients: mannitol - 3.6 mg, povidone K 17 - 2.4 mg, lactose monohydrate - 185.0 mg, potato starch - 45.0 mg, stearic acid - 2.0 mg.

Description:

round, flat-cylindrical tablets of white or white with a yellowish tint, with a chamfer, with a risk - on one side and with the inscription "PO" - on the other.

Pharmacotherapeutic group:

immunomodulatory agent.

ATX code:

Pharmacological properties

Pharmacodynamics

Azoximer bromide has a complex effect: immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory.

The basis of the mechanism of the immunomodulatory action of Azoximer bromide is a direct effect on phagocytic cells and natural killers, as well as stimulation of antibody formation and synthesis of interferon-alpha and interferon-gamma.

The detoxifying and antioxidant properties of Azoximer bromide are largely determined by the structure and high-molecular nature of the drug.

Azoximer bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency states caused by various infections, injuries, complications after surgical operations.

A characteristic feature of Azoximer bromide when applied topically (sublingually) is the ability to activate the factors of early protection of the body against infection: the drug stimulates the bactericidal properties of neutrophils, macrophages, enhances their ability to absorb bacteria, increases the bactericidal properties of saliva and mucous secretions of the upper respiratory tract.

When administered orally, Azoximer bromide also activates lymphoid cells in the intestinal lymph nodes.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins, heavy metal salts from the body, inhibits lipid peroxidation, both by intercepting free radicals and by eliminating catalytically active Fe 2+ ions. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, has no mitogenic, polyclonal activity, antigenic properties, does not have an allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effect.

Azoximer bromide is odorless and tasteless, does not have a local irritating effect when applied to the mucous membranes of the nose and oropharynx.

Pharmacokinetics

Azoximer bromide after oral administration is rapidly absorbed from the gastrointestinal tract, the bioavailability of the drug when administered orally is more than 70%. The maximum plasma concentration is reached 3 hours after ingestion. The pharmacokinetics of azoximer bromide is linear (plasma concentration is proportional to the dose taken).

Azoximer bromide is a hydrophilic compound. The apparent volume of distribution is approximately 0.5 l / kg, which indicates that the drug is distributed mainly in the interstitial fluid. The half-life is 35 minutes, the half-life is 18 hours.

Azoximer bromide is rapidly distributed throughout all organs and tissues of the body, penetrates through the blood-brain and hemato-ophthalmic barriers. There is no cumulative effect. In the body of Azoximer, bromide undergoes biodegradation to low molecular weight oligomers, it is excreted mainly by the kidneys, with faeces - no more than 3%.

Indications for use

It is used in adults and children from 3 years old for the treatment and prevention of acute and chronic respiratory diseases in the stage of exacerbation and remission.

For treatment (in complex therapy):

acute and exacerbation of chronic recurrent infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper and lower respiratory tract, inner and middle ear;

Allergic diseases (including hay fever, bronchial asthma) complicated by recurrent bacterial, fungal and viral infections;

For prevention (monotherapy):

recurrent herpetic infection of the nasal and labial region;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;

Secondary immunodeficiency states arising from aging or exposure to adverse factors.

Contraindications

Increased individual sensitivity;

Pregnancy, breastfeeding period;

Children's age up to 3 years;

acute renal failure;

rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

Carefully

If you have any of the conditions listed in this section, talk to your doctor before you start taking this medicine:

Chronic renal failure (use no more than 2 times a week).

Use during pregnancy and during breastfeeding

The use of the drug Polyoxidonium ® is contraindicated in pregnant women and women during breastfeeding (clinical experience is not available).

Experimental application of the drug Polyoxidonium ® in animals showed no embryotoxic and teratogenic effects, no effect on the development of the fetus.

Before using the drug Polyoxidonium ® , if you are pregnant, or think that you could be pregnant, or plan to become pregnant, you should consult your doctor.

During breastfeeding, before using the drug Polyoxidonium ®, you should consult your doctor.

Dosage and administration

Use the drug only according to the indications, the method of application and in the doses indicated in the instructions.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Orally and sublingually 20-30 minutes before meals daily 2 times a day: children over 10 years old and adults - 1 tablet, children from 3 to 10 years old - ½ tablet (6 mg).

If necessary, it is possible to conduct repeated courses of therapy after 3-4 months. With repeated administration of the drug, its effectiveness does not decrease.

sublingual

For adult treatment:

10 days;

Allergic diseases (including hay fever, bronchial asthma) complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 10 days.

For the treatment of children from 3 to 10 years:

Influenza and acute respiratory infections - ½ tablet 2 times a day for 7 days;

Inflammatory processes of the oropharynx - ½ tablet 2 times a day for
7 days;

Allergic diseases (including hay fever, bronchial asthma) complicated by recurrent bacterial, fungal and viral infections - ½ tablet 2 times a day for 7 days.

Influenza and acute respiratory infections - 1 tablet 2 times a day for 7 days;

Inflammatory processes of the oropharynx - 1 tablet 2 times a day for
7 days;

Exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis - 1 tablet 2 times a day for
7 days;

Allergic diseases (including pollinosis, bronchial asthma) complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 7 days.

For prevention in adults:

By
1 tablet per day for 10 days;

1 tablet 2 times a day for 10 days;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1 tablet once a day for 10 days;

Secondary immunodeficiencies arising from aging or exposure to adverse factors - 1 tablet 1 time per day for 10 days.

For prevention for children from 3 to 10 years:

Influenza and acute respiratory infections in the pre-epidemic period -
½ tablet per day for 7 days;

recurrent herpetic infection of the nasal and labial area -
½ tablet 2 times a day for 7 days;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - ½ tablet once a day for 10 days.

For prevention in children over 10 years of age:

Influenza and acute respiratory infections in the pre-epidemic period -
1 tablet per day for 7 days;

recurrent herpetic infection of the nasal and labial area -
1 tablet 2 times a day for 7 days;

Exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear, 1 tablet once a day for 10 days.

oral

For adult treatment:

For treatment of children over 10 years of age:

diseases of the upper and lower respiratory tract - 1 tablet 2 times 10 days.

Side effect

Side effects are not registered.

If you notice any side effects that are not listed in the instructions, tell your doctor.

Overdose

Cases of overdose are not registered.

Interaction with other drugs

Azoximer bromide does not inhibit isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, cytochrome P-450, so the drug is compatible with antibiotics, antiviral, antifungal and antihistamines, glucocorticosteroids and cytostatics.

If you are taking any of the above or other medicines (including over-the-counter medicines), talk to your doctor before taking Polyoxidonium.

special instructions

If an allergic reaction develops, stop using Polyoxidonium ® and consult a doctor.

If it is necessary to stop taking the drug Polyoxidonium ®, cancellation can be carried out immediately, without a gradual dose reduction.

If you miss the next dose of the drug, its subsequent use should be carried out as usual, as indicated in this leaflet or recommended by your doctor. The patient should not double the dose to make up for missed doses.

Do not use the drug if there are visual signs of its unsuitability (packaging defect, discoloration of the tablet).

Influence on the ability to drive vehicles and other mechanisms

In this medical article, you can get acquainted with the drug Polyoxidonium. The instructions for use will explain in which cases you can take suppositories, injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Polyoxidonium, from which you can find out if the medicine helped in the treatment of immunodeficiencies and related infectious diseases in adults and children, for which it is also prescribed. The instructions list the analogues of Polyoxidonium, the prices of the drug in pharmacies, as well as its use during pregnancy.

Polyoxidonium is an immunostimulating agent that increases the body's resistance to local and generalized infections. Instructions for use prescribe the use of 12 mg tablets, 6 mg and 12 mg suppositories, injections in ampoules for injections of 3 mg and 6 mg to increase the body's resistance to infectious pathologies.

Release form and composition

The following dosage forms of Polyoxidonium are produced:

Tablets 12 mg.
Candles for vaginal or rectal use 6 mg and 12 mg.
Lyophilisate for solution for injection and topical application (injections in ampoules) 3 mg and 6 mg.

The active substance is azoximer bromide (polyoxidonium):

vial of lyophilisate - 3 mg or 6 mg;
tablet - 12 mg;
suppository - 6 mg or 12 mg.

pharmachologic effect

The drug Polyoxidonium helps to restore the immune status in secondary immunodeficiency conditions caused by various infections, trauma, burns, malignant tumors, complications after surgical interventions, treatment with chemotherapeutic drugs, including cytostatic agents and steroid hormones.

Along with the immunocorrective effect of azoximer, bromide also has a pronounced detoxifying effect, which is due to the structure and high-molecular nature of this substance.

The result of its impact on the body is an increase in the resistance of cell membranes to the cytotoxic (causing cell damage up to their death) action of drugs and chemicals, as well as a decrease in the toxicity of the latter.

The appointment of Polyoxidonium in combination with other drugs increases the effectiveness of therapy by an order of magnitude, reduces its duration, allows you to reduce doses or completely avoid the use of antibiotics, bronchodilators and glucocorticosteroids, and helps to increase the period of remission (that is, the period of weakening or complete disappearance of symptoms of the disease).

The drug is well tolerated by patients, does not show mitogenic or polyclonal activity, does not have antigenic properties, does not provoke the development of allergies, mutations and other defects in the development of the fetus, does not have a teratogenic effect on the developing fetus, does not have carcinogenic and embryotoxic properties.

Why is Polyoxidonium prescribed?

Indications for the use of the drug include the correction of immunity in adults and children from 6 months.

What helps children? In complex therapy, pediatricians prescribe the drug:

intestinal dysbacteriosis (in combination with specific therapy);
atopic dermatitis complicated by purulent infection;
prevention of influenza and acute respiratory infections;
acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, SARS);
for the rehabilitation of often and long-term sick people;
acute allergic and toxic-allergic conditions;
bronchial asthma complicated by chronic respiratory tract infections.

In adults in complex therapy:

acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
with complicated acute respiratory infections during rheumatoid arthritis;
to activate regenerative processes (fractures, burns, trophic ulcers);
for the prevention of influenza and acute respiratory infections;
for the prevention of postoperative infectious complications;
chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the acute stage and in remission;
tuberculosis;
in oncology during and after chemotherapy and radiation therapy to reduce the immunosuppressive, nephro- and hepatotoxic effects of drugs;
acute and chronic allergic diseases (including pollinosis, bronchial asthma, atopic dermatitis) complicated by chronic recurrent bacterial and viral infection;
rheumatoid arthritis.

Contraindications

The use of Polyoxidonium is contraindicated in patients with hypersensitivity to the components of the drug. Azoximer bromide should be used with caution in the treatment of patients with acute renal failure. Lyophilizate and suppositories should not be prescribed during pregnancy and breastfeeding.

Lyophilisate: up to 6 months - with caution.
Tablets: up to 12 years.
Candles: children under 6 years.

Instructions for use

Pills

Polyoxidonium instructions for use prescribe to take orally or sublingually. It is recommended to take half an hour before meals twice a day. Children over the age of 10 years and adult patients are prescribed one tablet each. Children 3-10 years old are prescribed ½ tab. If necessary, and according to the instructions of the doctor, it is possible to repeat the course of treatment in 3-4 months.

sublingual pills

Dosage for the treatment of adult patients and children over 10 years of age:

Exacerbation of chronic diseases of the upper respiratory organs and otitis is prescribed 1 tablet twice a day for 10 days, for patients 10-18 years old - the duration of therapy is 7 days.
For the treatment of allergic diseases complicated by a fungal, viral or bacterial infection, the recommended dose is 1 table. twice a day for 10 days, and for children 10-18 years old - for a week.
Influenza and SARS - 1 tablet twice a day for a week.
Inflammatory lesions of the oropharynx - 1 tab. twice a day for 10 days, children 10-18 years old for 7 days.
For the treatment of the above diseases in children, ½ tab. twice a day for a week.

Disease prevention:

Secondary immunodeficiencies: adults - 1 tablet per day for 10 days.
SARS and influenza: adults - 1 tab. per day for 10 days; children 3-10 years old - ½ tab. per day for a week.
Herpes of the nasal and labial region: adults - 1 tab. twice a day for 10 days; children 3-10 years old - ½ tab. twice a day for 7 days.
Exacerbation of chronic infectious diseases of the ear, oropharynx and upper respiratory organs: adults: 1 tab. per day for 10 days; children 3-10 years old - ½ tab., course of treatment - 10 days.

Oral pills

The drug is taken to treat children over 10 years of age and adult patients. The recommended dosage is 1 tablet twice a day for 10 days.

Suppositories Polyoxidonium

Candles 12 mg and 6 mg are administered rectally, after the bowel cleansing procedure, once a day (before bedtime). A single dose is one suppository. The scheme of their introduction is as follows: daily one at a time in the first 3 days, then - also one at a time - after 2 days. For a full course, 10 suppositories are required.

Intravaginal use is indicated for the treatment of gynecological diseases: dysplasia, erosion, leukoplakia of the cervix, colpitis, adnexitis, endometritis, as well as diseases provoked by human papillomavirus (HPV).

Treatment involves the daily administration of one suppository for three days with a dosage of the active substance of 12 mg, after which the suppositories continue to be administered every other day. The course is carried out using 10 suppositories. In cases where it is advisable, the course of treatment can be repeated after 3-4 months.

Patients who have been diagnosed with chronic immune deficiency (including, but not limited to, patients in whom such a condition was the result of an oncological disease) are prescribed Polyoxidonium as a maintenance agent at a dose of 6 or 12 mg (according to the doctor's indications) 1-2 times a week. The treatment is long.

Lyophilisate

Injections in ampoules are intended for parenteral (intramuscular (IM) or intravenous (IV)), intranasal administration and sublingual administration in children. Solution preparation rules:

V / m administration: for adults - dissolve the contents of 1 vial (6 mg) in 1.5-2 ml of water for injection or 0.9% sodium chloride solution; for children - dissolve 3 mg of the drug in 1 ml of 0.9% sodium chloride solution or water for injection;

In / in drip injection: for adults - dissolve the contents of 1 vial (6 mg) in 2 ml of 5% dextrose solution, 0.9% sodium chloride solution, gemodez-N or reopoliglyukin, then mix with the selected solution in a volume of 200-400 ml; for children - dissolve 3 mg in 1.5-2 ml of 0.9% sodium chloride solution, gemodez-N, rheopolyglucin or 5% dextrose solution, then transfer the resulting solution into a vial with 150-250 ml of the selected solution;

Intranasal administration: for adults - the contents of 1 bottle (6 mg), for children - ½ bottle (3 mg), should be dissolved in 1 ml of 0.9% sodium chloride solution, distilled or boiled water at room temperature.

One drop of the resulting solution for intranasal administration in children contains 0.15 mg of azoximer bromide. This solution is also used for sublingual use, it can be stored for no more than 7 days in the refrigerator, before use, the pipette is heated to room temperature.

Solution for parenteral administration should be prepared before direct use. The route of administration and dose is determined by the doctor based on clinical indications, taking into account the age of the patient. Recommended dosage for parenteral administration:

Tuberculosis: 6-12 mg 2 times a week, the course of treatment is 10-20 injections;
Correction of immunodeficiency after surgical removal of the tumor, radiation and chemotherapy, prevention of immunosuppressive action: 6-12 mg 1-2 times a week for a long period. In acute renal failure, the drug should be administered no more than 2 times a week.
Acute inflammatory pathologies: adults - 6 mg per day for 3 days, then - 1 time in 2 days, only 5-10 injections; children - at the rate of 0.1 mg per 1 kg of the child's weight per day, the procedure is carried out every other day, in total - 5-7 injections;
Rheumatoid arthritis: 6 mg every other day - 5 injections, then - 2 times a week, at least 10 injections in total;
Acute and chronic urogenital pathologies: 6 mg every other day, only 10 injections in combination with chemotherapy drugs; Chronic recurrent herpes: 6 mg every other day, course of therapy - 10 injections while prescribing antiviral agents, interferons and inducers of interferon synthesis;
Chemotherapy for oncological pathologies: 6-12 mg every other day, the course is at least 10 injections, then the frequency of administration is prescribed individually, taking into account the tolerability and duration of radiation and chemotherapy;
Complicated forms of allergic diseases: adults - 6 mg 1 time per day for 2 days, then - every other day, only 5 injections; children - intramuscularly at 0.1 mg per 1 kg of body weight per day after 1-2 days, in total - 5 injections in combination with basic therapy;
Inflammatory diseases of chronic origin: adults - 6 mg 1 time per day every other day (5 injections), then - 2 times a week, the course of treatment - at least 10 injections; children - 0.15 mg per 1 kg of weight every 3 days, the course of treatment - up to 10 injections;
Acute allergic and toxic-allergic conditions (in / in combination with antiallergic drugs): adults - 6-12 mg, children - 0.15 mg per 1 kg of weight;

Recommended dosing for intranasal administration:

Adults: 3 drops in each nasal passage 3 times a day for 5-10 days;
Children: 1-3 drops in one nasal passage 2-4 times a day.

Sublingual intake of the solution for children (for all indications): 0.15 mg per 1 kg of body weight per day for 10 days, and with intestinal dysbacteriosis - 10-20 days.

Side effects

The use of the lyophilisate may cause pain at the injection site.

Children, during pregnancy and lactation

The drug is contraindicated for use during pregnancy and breastfeeding. Experimental studies on animals have not revealed a negative effect of Polyoxidonium on the fertility of females and males.

Also, no teratogenic and embryotoxic effects of the drug and its effect on the development of the fetus during the entire pregnancy and during lactation were found.

special instructions

For suppositories and tablets.

The patient should be aware that the duration of the course of therapy and the indicated doses should not be exceeded without prior consultation with the attending physician.

For lyophilisate for the preparation of an injection solution.

In case of pain at the injection site with intramuscular injection, Polyoxidonium is dissolved in 1 ml of a 0.25% solution of procaine (provided that the patient is not hypersensitive to procaine). With intravenous (drip) administration, the lyophilisate is not recommended to be dissolved in protein-containing infusion solutions.

All dosage forms are compatible with antiviral, antibiotics, antihistamines and antifungals, corticosteroids, bronchodilators, cytostatics. The drug does not affect the ability to manage complex mechanisms and drive a car.

drug interaction

It is allowed to use Polyoxidonium in combination with antibiotics, antiviral and antihistamines, antimycotics, cytostatic, glucocorticosteroid and bronchodilator drugs, β-agonists.

If it is necessary to administer the solution by drip into a vein, it should not be diluted with infusion solutions containing proteins.

Polyoxidonium's analogs

Analogues of the drug according to the mechanism of action:

Broncho Wax.
Affinoleukin.
Arpeflu.
Neuroferon.
Actinolysate.
Florexil.
Glutaxim.
Vilozen.
Anaferon.
Ribomunil.
Engystol.
Immunofan.
Immunal.
Ismigen.
Cycloferon.
Taktivin.
Herbion.
Cytovir-3.
Gepon.
Bioaron.
Polymuramyl.
Bestin.
Isophon.
Arpetolid.

Holiday conditions and price

The average price of Polyoxidonium (tablets 12 mg No. 10) in Moscow is 570 - 765 rubles. Vaginal and rectal suppositories 6 mg (10 pcs per pack) can be bought for 795-910 rubles, injections - 665-755 rubles. In Kyiv, you can buy medicine for 16 hryvnia, in Kazakhstan - for 245 tenge.

In Minsk, pharmacies offer the drug for 2 bel. ruble. Implemented according to the recipe. Tablets and suppositories belong to the category of over-the-counter drugs, a prescription is required to purchase the lyophilisate.

The drug is contraindicated in persons with individual intolerance to its components.

Side effects

Side effects of the use of tablets and suppositories are hypersensitivity reactions. With intramuscular injection of the drug, some patients may experience redness and soreness at the injection site. After the first injections of Polyoxidonium, body temperature may rise.

Instructions for Polyoxidonium (Method and dosage)

The dose and route of administration will be determined depending on the diagnosis, the characteristics of the course of the disease and the age of the patient.

Instructions for Polyoxidonium tablets

The tablets are intended for sublingual (under the tongue) or oral (by mouth) administration. They are drunk daily, one, two or three times a day (the frequency of doses depends on the nature of the disease and the severity of the clinical picture) 20-30 minutes before meals.

A single dose of the drug for adults - 1 tablet (equivalent to 12 mg azoximer bromide ), children from 3 to 10 years old are prescribed to take 0.5 tablets per dose.

Instructions for use Polyoxidonium in the form of lyophilisate

The solution is administered intramuscularly or by drip into a vein, applied intranasally.

For treatment acute inflammatory diseases the drug is administered daily for 3 days at a dose of 6 mg. Further, injections of Polyoxidonium continue to be done every other day. As a rule, the patient requires five to ten injections.

For treatment chronic inflammatory diseases And rheumatoid arthritis the first 5 injections are made every other day, then the drug is continued to be administered 2 times a week. A single dose of the active substance is 6 mg. The full course involves at least ten injections.

Patients who are diagnosed are prescribed to administer 6 mg of the drug 2 times a week. Full course - from ten to twenty injections.

Patients with diseases of the urogenital tract ten injections are recommended (every other day). Single dose - 6 mg. Therapy is supplemented by the appointment chemotherapy drugs .

Patients with chronic relapsing . At the same time, Polyoxidonium is prescribed in combination with endogenous interferon synthesis stimulators, antiviral agents, drugs interferon .

Therapy occurring in a complicated form allergic diseases involves the administration of five single doses of the drug (6 mg) to the patient. The first two injections are recommended to be done daily, the remaining three injections are done every other day.

Patients who are taking the course chemotherapy (and also after its completion) to reduce the specific action of chemotherapeutic agents, the drug is prescribed at a dose of 6-12 mg. It is considered optimal to carry out at least ten injections (withstanding a daily interval between them).

For the correction of an immunodeficiency state after radiation and chemotherapy, after surgical removal of the tumor the patient is administered a dose of 6 mg 1-2 times a week. The course of treatment is quite long - usually from 2-3 to 12 months.

According to the instructions for use, Polyoxidonium injections for patients with acute it is allowed to administer the drug no more than 2 times a week.

To prepare a solution for intramuscular injections, 6 mg of the active substance (the contents of one ampoule or vial) are combined with 1.5-2 ml of NaCl solution or water for injection.

A solution for drip injection into a vein is prepared by mixing the contents of one ampoule or vial with 3 ml of NaCl solution, plasma-substituting drug or 5% glucose solution. The resulting solution must be transferred under sterile conditions into a vial with any of the indicated solutions with a volume of 0.2-0.4 liters.

The solution for parenteral administration must be used immediately after preparation, it is not subject to storage.

Intranasal use is indicated for acute and chronic infectious ENT diseases, to accelerate the regeneration of mucous membranes, to prevent the development of complications and relapses of diseases, to prevent influenza and respiratory diseases.

To prepare a nasal solution, 6 mg of the lyophilizate is combined with one milliliter (20 drops) of distilled water, NaCl solution or ordinary boiled water. In this case, the temperature of the liquid should be at room temperature.

The solution is injected at least 3-4 times a day into each nasal passage, keeping 2-3 hours between instillations. A single dose is 1 to 3 drops in each nostril. Treatment is continued for five to ten days.

After dilution, the drug remains stable for a day, after which it can not be used.

Candles Polyoxidonium, instructions for use

Intravaginal application is indicated for the treatment of gynecological diseases: dysplasia , leukoplakia of the cervix , colpitis , adnexitis , endometritis , as well as diseases provoked human papillomavirus (HPV).

Patients who have been diagnosed with chronic immune deficiency (including but not limited to patients in whom such a condition was the result of oncological disease ) Polyoxidonium is prescribed as a maintenance agent at a dose of 6 or 12 mg (according to the doctor's indications) 1-2 times a week. The treatment is long.

Overdose

There are no data on overdose of Polyoxidonium in the form of tablets and suppositories. When using the solution in prescribed therapeutic doses, cases of overdose have also not been recorded. Potentially increased side effects.

In case of signs of overdose, symptomatic therapy is recommended.

Interaction

It is allowed to use Polyoxidonium in combination with antiviral and antihistamines, antimycotics , cytostatic, glucocorticosteroid and bronchodilator drugs, β-agonists .

If it is necessary to administer the solution by drip into a vein, it should not be diluted with infusion solutions containing proteins.

Terms of sale

Tablets and suppositories belong to the category of over-the-counter drugs, a prescription is required to purchase the lyophilisate.

Storage conditions

Pills stored at a temperature not exceeding 25°C. Keep away from children

suppositories are included in list B. It is recommended to store them in a dry, dark place. Keep away from children. The optimum temperature regime is from 2° to 15°С.

Lyophilisate should be stored in a dry, dark place. The optimum temperature regime is from 4 to 8 ° С. Keep away from children.

Best before date

Polyoxidonium analogues

Coincidence in the ATX code of the 4th level:

Analogues of the drug according to the mechanism of action: Actinolysate , Arpetolide , Affinoleukin , bestin , Bioaron , Vilozen , , Herbion , Glutaxim , Isophon , Immunofan , Neuroferon , Florexil , Polymuramil , Ismigen .

Polyoxidonium for children

In pediatric practice, the use of tablets is allowed from the age of 3, suppositories are used from the age of six, lyophilisate is used from six months.

Polyoxidonium is prescribed for children as an addition to the main therapy. Indications for use are acute and chronic infectious and inflammatory diseases (including but not limited to SARS And ENT diseases ), allergy And toxic-allergic conditions complicated by chronic infectious processes in the respiratory tract, occurring with complications (including complicated by purulent infection) atopic dermatitis, dysbacteriosis .

For children included in the "CHBD" group, the drug is used to speed up the process of their rehabilitation. In addition, Polyoxidonium has a preventive effect against influenza And colds .

Tablets are taken sublingually or orally at a dose of 6 mg (half a tablet), daily, with a frequency of applications 1, 2 or 3 times a day.

The optimal dose, number and frequency of injections are determined depending on the diagnosis and age of the child:

With acute inflammatory diseases carrying out in a day from five to seven injections is shown. Dose - 100 mcg / kg. If the disease is chronic, the dose is increased to 150 mcg / kg. The introduction of the drug is carried out every other day. The course involves the introduction of up to ten single doses.
For treatment allergies And toxic-allergic conditions drip injection of the drug into a vein at a dose of 150 mcg / kg is indicated. Therapy is supplemented with the appointment of other drugs that have an antiallergic effect. If the disease proceeds with complications, injections are prescribed as an addition to basic therapy. The patient is shown 5 intramuscular injections at a dose of 100 mcg/kg. The interval between injections is 1-2 days.

A solution for intramuscular injection is prepared by dissolving 3 mg of the drug in 1 ml of NaCl solution (you can use water for injection).

A solution for intravenous administration is prepared by diluting 3 mg of the drug in 1.5-2 ml of NaCl solution, 5% glucose solution, or , after which, under sterile conditions, they are added to a vial with one of the indicated solutions with a volume of 0.15-0.25 liters.

Polyoxidonium is administered intranasally daily for five to ten days, instilled at least 3-4 times a day in each nostril at a dose of 1 to 3 drops. The daily dose is 150 mcg/kg of body weight. The interval between procedures is 2-3 hours.

To prepare a solution for topical application, 1 ml (equivalent to 20 drops) of room temperature liquid (0.9% NaCl solution, distilled or ordinary boiled water) is added to 3 mg of the drug.

For children, the solution is prescribed at a dose of 150 μg of the active substance per kilogram of body weight (this amount is contained in one drop of the solution).

Sublingual drug is prescribed to be taken daily for 10 days. The daily dose for all indications is 150 mcg / kg. If the drug is used to treat dysbacteriosis, the course lasts, as a rule, from 10 to 20 days.

The solution is stored in the refrigerator for no more than one week. Before instillation of the drug, the pipette with the solution must be heated to room temperature.

According to the instructions for suppositories for children, the drug in this dosage form is allowed to be used rectally for the treatment of patients older than 6 years. Suppositories, according to the doctor's indications, are administered one at a time or every other day before bedtime.

Polyoxidonium candles for children - reviews confirm this - an effective remedy, however, it is possible to achieve the desired effect from their use only in cases where the treatment regimen is selected by an experienced doctor, and takes into account the characteristics of the disease and the body of a particular child.

Application for pregnant and lactating women

There are no data on the safety of using Polyoxidonium in pregnant and lactating women, and therefore the drug is not prescribed to these categories of patients.

Reviews for Polyoxidonium

Reviews about the drug are mostly positive. This is due to the fact that it effectively treats chronic and complicated diseases that cannot be treated with standard therapy.

Reviews for Polyoxidonium in suppositories, tablets and solution are evidence of the effectiveness of each of these dosage forms. Against the background of the use of the drug in complex therapy, the patient recovers faster, and the disease proceeds in a much milder form.

Using the drug as a prophylactic for children can reduce the incidence of diseases. Reviews of doctors on Polyoxidonium allow us to conclude that this remedy is really indispensable.

Prescribing candles, tablets or nasal solution to children contributes to faster adaptation to being in a team (at school or kindergarten). At the same time, children are much less susceptible to infections even during periods of seasonal epidemics.

Most of the positive reviews for Polyoxidonium in suppositories and other dosage forms are due to the fact that the drug is easy to use, well tolerated by children and practically does not cause side effects.

Adults Polyoxidonium is most often prescribed for the treatment of infectious diseases. The use of suppositories in gynecology in combination with the main therapy contributes not only to the effective elimination of the symptoms of the disease, but also significantly increases and, accordingly, helps prevent relapses and complications.

After analyzing the reviews about Polyoxidonium injections, we can say with confidence that the drug has a positive effect even in rather difficult cases when the patient's body is weakened cancer and his treatment.

Rare negative reviews are due to the fact that the drug did not give visible changes in the patient's condition, which in some cases may be the result of an incorrectly selected regimen that does not take into account the individual characteristics of the patient's body.

The reviews note the high cost of Polyoxidonium, however, given that the drug is effective, helps quickly and for a long time, facilitates the course and reduces the frequency of diseases, does not cause pain when administered (this applies to all dosage forms except for injections, the latter, on the contrary, are very painful) , this "flaw" for most patients fades into the background.

Polyoxidonium price, where to buy

The average price of Polyoxidonium tablets is 540 UAH. The price of Polyoxidonium 12 mg candles is 750 UAH, you can buy 6 mg candles for an average of 580 UAH. The price of Polyoxidonium in ampoules (6 mg injections) is from 600 to 1200 UAH.

You can buy 12 mg tablets in Moscow for an average of 660-750 rubles. The price of 6 mg ampoules is from 950 rubles. Candles 6 mg cost approximately 750 rubles, candles 12 mg - 850 rubles.

Internet pharmacies in Russia Russia
Internet pharmacies of Kazakhstan Kazakhstan

ZdravCity

Polyoxidonium Lyof. for ca. solution for injections. and local approx. 3mg #5Petrovax Pharm NPO LLC

Polyoxidonium Lyof. for ca. solution for injections. and local approx. 6mg fl. #5Petrovax Pharm NPO LLC

Polyoxidonium vaginal suppositories. and rectal. input. 12mg #10Petrovax Pharm NPO LLC

Polyoxidonium vaginal suppositories. and rectal. input. 6mg #10Petrovax Pharm NPO LLC

Petrovax Pharm NPO LLC

Pharmacy Dialog * discount 100 rubles. by promo code medside(for orders over 1000 rubles)

Polyoxidonium tablets 12mg №10

Polyoxidonium suppositories 6mg №10

Polyoxidonium (flask 0.003g No. 5)

Polyoxidonium (flask 0.006g No. 5)

Europharm * 4% discount with promo code medical11

Polyoxidonium suppositories 6 mg n10R.P.Scherer GmbH & Co.KG

Polyoxidonium lyophilisate for injection 3 mg n5Petrovax Pharm NPO, OOO

Polyoxidonium suppositories 12 mg n10Petrovax Pharm NPO, OOO

Polyoxidonium lyophilisate for injection 6 mg n5Petrovax Pharm NPO, OOO

Polyoxidonium tablets 12 mg n10Petrovax Pharm NPO, OOO

Pharmacy IFK

Petrovax Pharm NMC LLC, Russia

BIOSPHERE

Polyoxidonium 3 mg No. 5 por.lyof.d / in. flak.
Polyoxidonium 12 mg №10 supp.Petrovax Pharm OOO NPO (Russia)
Polyoxidonium 6 mg №10 supp.Petrovax Pharm OOO NPO (Russia)
Polyoxidonium 6 mg No. 5 por.lyof.d / in. flak.Petrovax Pharm OOO NPO (Russia)
Polyoxidonium 12 mg No. 10 tab.Petrovax Pharm OOO NPO (Russia)
show more

Author-compiler:- pharmacist, medical journalist Speciality: Pharmacist

Education: She graduated from the Rivne State Basic Medical College with a degree in Pharmacy. Graduated from the Vinnitsa State Medical University. M.I. Pirogov and an internship based on it.

Experience: From 2003 to 2013 she worked as a pharmacist and head of a pharmacy kiosk. Awarded with certificates and distinctions for long-term and conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

NOTE! Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before medicine use Polyoxidonium surely consult with the attending physician.

Maruseva | 17:04 | 06.06.2019

Camille | 17:04 | 06.06.2019

The pediatrician prescribed polyoxidonium suppositories for us, I heard about them for the first time, but to be honest, they had never seen a better medicine before. My daughter is 7 years old, she fell ill with the usual ARVI, but complained that these colds became more frequent with us. This is probably why they were prescribed to us, because I later read in the instructions that immunity strengthens well. Indeed, we have not been sick at all for 2 months after them. But I would also like to say that polyoxidonium in suppositories very well and quickly helps to treat the cold itself, it really removes the symptoms, does not make it very ill, it gets better the very next day and everything generally goes easier and faster.

Polezhaykina A. | 17:50 | 08.05.2019

Polyoxidonium suppositories are very effective in viral diseases. I only raise both children with them to their feet. Although they have become much less likely to get sick with me, they still caught the flu in a new wave of the epidemic, it’s just that their whole school is sick, I can imagine what a hotbed of infection there. We have already taken polyoxidonium before, and it has proven to be an effective drug. With it, my children tolerate colds more easily and recover faster. Previously, sometimes there were even complications, but here they even began to hurt less. Thank you for such effective products.

Bush T | 17:13 | 09.04.2019

At the insistence of a doctor friend, I recently bought polyoxidonium tablets for complex treatment. Acutely fell ill with a temperature of 39.6, did not go astray. This is a new epidemic of a dangerous influenza virus, against which even vaccinations did not work. It is manifested by severe intoxication, and apart from polyoxidonium, no antiviral drugs remove toxins. He really helped me to endure the flu easier and faster. The temperature returned to normal in two days, headaches and malaise also disappeared. In general, I recovered in 4-5 days, probably. Thank you polyoxidonium.

Svetlana | 19:27 | 14.03.2019

I have been treating my family with polyoxidonium for a long time, we have pills, my daughter has candles. After we started taking polyoxidonium, we don’t get sick so often, but my husband and I caught a new wave of the epidemic, it’s just that the virus is already very strong. And the daughter is well done, lasted. Polyoxidonium helps to significantly reduce symptoms, it is easier and faster to endure a cold, and without side effects, I recommend it to everyone.

Olesya | 10:09 | 03.03.2019

If there is no time to get sick, I advise everyone to use polyoxidonium. My therapist suggested it to me. I picked up a wave of the epidemic, when everyone was sick, there were pain in the eyes, my head was splitting, my throat was tickling - a full bouquet. And polyoxidonium coped with this bouquet very quickly and effectively. After 2 days I returned to normal mode, and recovered faster. But of course, I drank the course to the end

Inga Leonova | 13:44 | 30.01.2019

I bought polyoxidonium as prescribed by a doctor. A long cold was complicated by purulent tonsillitis. The state of health was generally normal, but the temperature did not pass, and a sore throat appeared when swallowing. The lozenges helped very quickly, the next day the temperature subsided. I used 2 packs for the full course (10 days, 2 tablets 2 times a day). Works efficiently and quickly, I advise.

Zavyalova | 11:59 | 11.01.2019

Adaptation to the kindergarten did not pass us by, although she tried to harden the child and gave him fresh fruits and berries from his grandmother in the village. Everything is according to the book: snot, fever, sluggish all over, capricious, sometimes wants to sleep, sometimes does not want to. And I'm already tired of taking weekends at my own expense. Went to a private doctor. She looked at her son, said that everything is standard, but it is worth drinking Polyoxidonium, it is often prescribed for children. She said that the child will adapt faster and generally recover faster this time. They drank one tablet a day, divided in half. So ten days. On the sixth we went to the kindergarten, but did not stop drinking. We've been going here for six months now and have never gotten sick. Some kind of magic.

Fedyunin | 12:29 | 26.12.2018

In my lifetime, I have tried many different antiviral agents. Most of it is difficult to characterize without mats. The rest on antihistamine components, ascorbic acid and paracetamol leave. It's like being renovated. Some cracked glass is sealed with adhesive tape so that it does not blow, while others change windows. So these funds represent the first option. It gets easier, but the problem remains. And Polyoxidonium in tablets just helps to eliminate the cause of the disease. My wife bought it for me for the flu. So he put me on my feet at the very beginning of the course of treatment, in 1-2 days. Looks like this drug has processed the immune system well. Now it's like clockwork. Not a single virus slips for a long time already.

Maria | 10:49 | 07.12.2018

ARVI has always been difficult for us. We drank cough pills, dripped our noses, did inhalations, kept the bed and drinking regimen, but still we constantly had to deal with complications as a result. Most often, angina appeared. And this is severe pain when swallowing, swollen tonsils and fever. Helped us change the situation Polyoxidonium. The pediatrician decided that the natural defenses of the child's body needed help and prescribed this immunomodulator. Previously, 2-3 weeks could be treated, and with it a maximum of 4-5 days. It turns out that the child recovers several times faster and then almost does not get sick anymore, because. immunity is strengthened thanks to Polyoxidonium. As a mother, I am completely satisfied with the result.

Galina Ermoshina | 12:30 | 06.12.2018

The doctor prescribed a well-known antiviral agent for ARVI to my daughter. We drank the entire course, but in the end we had to switch to antibiotics anyway. And this year, as soon as she had the first signs of the disease, I gave her Policosidonium in tablets. Quite another matter! My daughter didn’t get sick at all, she had a slight runny nose and a temperature, but it all went away in a few days. I confirm that the drug is good, and the price does not scare me, since the effect is 100%.

Olga | 16:05 | 02.12.2018

Vitamins, sports, hardening procedures and fruits and vegetables are all good, but sometimes the immune system needs real help. Especially after childbirth, antibiotics or if you are overloaded at work for a long time. For example, the immunologist Polyoxidonium prescribed me to raise my resistance to infections. Has passed or has taken place ten-day course 7 months ago. While the “flight is normal”) there has never been flu and SARS))

Ludmila Kazachenko | 14:38 | 02.08.2018

Now is the best time to prepare your child for kindergarten. I did this last summer: I gave my son Polyoxidonium to drink 1.5 months before I took him to kindergarten and it helped! 7 months before the winter flu lasted. Now this is my working scheme.

Alina | 12:22 | 25.07.2018

It quickly puts it on its feet, there is an evidence base, otherwise other antiviral drugs have problems with this now. I have been buying polyoxidonium as a medicine for colds and flu, for 2 years now. It is important for me that appropriate studies have been conducted on this drug. In addition, the child does not develop allergies from it, as if due to the fact that it does not contain substances of plant and animal origin.

Olga | 12:15 | 16.07.2018

A good remedy, I always make sure that there are a couple of packs at home. In winter, it saves from flu and colds, and in summer it helps if I start acclimatizing from a flight to hot countries during my vacation or get herpes out. Usually this manifests itself in me in temperature and fever for several days, and sometimes a runny nose, well, and herpes - where would I be without it!). Polyoxidonium helps to quickly cope with this and relax calmly, especially since my vacation often lasts only a week.

Sintia | 15:35 | 05.07.2018

Polyoxidonium is sold in pharmacies without a prescription, i.e. when 1 pack runs out and in order to buy a new one, you don’t have to stand in line to the doctor again and so on. In addition, this is our domestic drug and you can easily buy it at any pharmacy. The fact that the drug is proven and effective cannot but rejoice, now this is the main thing. You can buy it both in tablets and in suppositories or lyophilisate. I prefer pills because I can't miss work meetings. And put the pills under the tongue and forget. The price is adequate for me, all the same, you save on buying a lot of unnecessary things ...

Louise | 9:51 | 15.06.2018

I always take polyoxidonium with me to the sea. I often get general malaise and a slight temperature due to climate change. Those who have experienced this will understand me. If I start taking polyoxidonia two days before leaving for the sea, then everything will be OK. Well, if the temperature is still there, then a day, a maximum of two. The whole point is that polyoxidonium activates the immune system, and acclimatization often occurs in people with reduced immunity.

Lisa | 13:44 | 12.06.2018

I tried different antiviral ones, but this year, and in the past, I bought exactly polyoxidonium. And I probably will continue to buy) I have no allergies to it. I don’t know what is being added to our medicines now, but this is already a pattern for me, allergies very often occur. But there is no polyoxidonium, I read it, this is because it does not have plant substances in its composition, it turns out like that :) Well, it’s not normal to choose a medicine for allergenicity, I think, and this particular medicine also helps great, so I advise

Agnia | 13:05 | 11.05.2018

I took it last winter when I got the flu. Of course, I had to lie at home for 10 days, but I noticed that with polioskidonium it was somehow easier to hurt. Not like last year, when I was in bed for almost 2.5 weeks with a high fever and could barely raise my head. With these pills, after four days, the temperature dropped from 39 to 37.5. The head did not hurt, the body aches was only the first two days. After all, I didn’t get sick for a long time, I didn’t meet with the flu this year))) I think this is all the merit of polyoxidonium.

Tasha | 14:53 | 06.05.2018

Polyoxidonium was prescribed to my daughter during a cold. we didn’t have any problems, it’s in pills and it needs to be absorbed, my daughter is 5 years old and she calmly took the pill and absorbed it) The pills are not bitter and this is a big plus, now I know how we will be treated if we fall ill again. But for the last 4 months nothing has been caught, even the March virus

Ulyana | 14:48 | 26.04.2018

Obviously not a pill for all diseases, but one of the best in its segment. The whole family often got sick for a long time, after a course of pills (I can’t help but notice how convenient it is to give a child a pill under the tongue), immunities began to work much better. If SARS, and this happens infrequently, then 4-5 days and that's it, on business.

Grisha | 21:49 | 08.04.2018

I am an adult, and until last year I did not really know how to be treated. Well, I understand there is raspberry tea, but everything is always with complications, these colds after any cold. I'm tired. I went to the doctor like a normal person, well, finally began to be adequately treated. They prescribed polyoxidonium tablets, I immediately began to drink. It seems to me that everything went so easily ... Like never before. On the 4-5th day he was generally healthy, he himself was in a culture shock. And now I have been living without diseases for almost a year. Honestly, guys, I did not expect such an effect) Probably just this medicine suits me 100%

Siniza | 11:24 | 31.03.2018

I have polyoxidonium - this is the medicine that you carry with you so as not to get sick in the region. I am a great boss, any absence from work is idleness, so I try to take sick leave in very rare cases. Thanks to the pills, I rarely get sick, and if it happens, then a couple of days and again in the ranks. At this time I go to work, I noticed that the performance remains the same, my head is fresh. And by the way, I don’t feel like sleeping, like from those antiviral drugs that I drank before!

Lesya | 17:19 | 10.03.2018

That winter I was treating my beloved schoolboy) I came home all blue, snot tinny, sneezes like crazy ... I don’t remember him being so sick at all ((I got nervous myself, I also threw up. In short, I put my legs in my hands, called the doctor, she she said - a virus, we are being treated with polyoxidonium. I had not heard about it before, although how did I manage it) We were prescribed in tablets, although I know that it is also produced in suppositories and in a solution for injections. I also want to say that polyoxidonium is suitable even for allergy sufferers (this I speak from our experience, because my son often has an allergy to medicines, but he didn’t have this drug), so it’s also a plus.In general, on the 2nd day, my miracle even began to play the console, I touch my forehead - it’s warm, but although would not burn. It’s good that it works quickly, otherwise sometimes, as you read, the children get sick for weeks, I really didn’t want to. So here it is: after another 5 days, cucumber-cucumber and galloped to school. Such an experience, after this virus did not I was ill before this New Year.

Tilda | 16:28 | 10.02.2018

Polyoxidonium helps even if the disease has already broken out. And this pleases the most. Because sometimes it happens that you feel some kind of malaise and it seems that I’ll lie down for one day and everything will pass. And then you can get really sick. And then polyoxidonium helps out. So with the advent of cold weather, I always check that it is in the first-aid kit at home.

The agent sold under this brand is a fully synthetic high-molecular compound discovered by Russian scientists in 1997, patented by the head of the research group. According to the manufacturer, Polyoxidonium for immunity increases resistance mainly to viruses, but it was also created for invasions of other types, except for helminths, and has almost no contraindications and side effects. It is suitable for use by children and individuals.

Description and composition

Polyoxidonium was developed and declared by the manufacturer as an immunomodulator - which changes the activity indicators of certain links of protection, and not all at the same time, like.

In this case, those responsible for antiviral activity. The polymer compound at its base is called azoximer bromide and has the following properties:

anti-inflammatory;
immunomodulatory;
antioxidant;
detoxification agent in case of poisoning with spoiled food, poison, toxins of helminths, bacteria and other pathogens, chemotherapy drugs.

It is assumed that the polycationic chains of azoxymer bromide reduce the synthesis of cytokine acute-phase proteins and assemble molecules in antibody membranes into certain clusters. This changes their bilateral permeability, forcing them to work faster. Due to this, it is noted for fungi, viruses, bacteria.

The exact mechanism of its action has not been studied. The tool has not undergone preliminary studies in humans (there is a feeling that it is now, in the "field conditions" of over-the-counter sales). The composition of Polyoxidonium differs depending on the form of release, but in all of them there are:

crosspovidone is an absorbent with a large molecular weight that is not absorbed from the intestine;
mannitol is a diuretic, a polysaccharide by origin.

Release form

The tool in any form is available with a dosage of 6 or 12 mg. The solution has a lower concentration - 3 and 6 mg. Now the manufacturer offers rectal suppositories and Polyoxidonium.

A lyophilisate for external topical use and injections is commercially available - mainly at a promotional price. But on the official website of the manufacturer, the instructions for it have not been available for several years, although references to this form have been preserved.

Possibly, the ambiguous situation is related to the 2006 recall episode of several batches of the Grippol vaccine, which also included azoximer bromide and the rights to which belong to its own manufacturer. Nearly 100 people throughout the Russian Federation, acute allergic reactions to the drug were detected, but no deaths were recorded.

The Rospotrebnadzor check confirmed the direct "participation" of the active substance Polyoxidonium in their development. And the lyophilisate implies its intramuscular injection similar to the vaccine. There is no publicly available data on its withdrawal from production or revocation of the license. But the overall picture is reminiscent of attempts to discreetly withdraw a compromised form from the market.

Indications and contraindications

Officially, it is believed that the drug can be used for children from six months, with autoimmune diseases, together with corticosteroids (immunosuppressors) - for all categories of patients, with the exception of:

allergic to azoximer bromide or excipients;
nursing mothers (due to the poor knowledge of its effect on the fetus and newborn);
patients with acute renal or hepatic insufficiency.

The instructions do not contain specific instructions for its use and action for hemorrhoids, hyperplasia, erosion and cervical cancer.

There are age restrictions on the use of individual forms:

tablets - not for children until the swallowing reflex is formed;
– do not prescribe before the 6-year threshold;
injections of lyophilizate intramuscularly/intravenously are also indicated from 6 years and older.

But because of the cases of complications mentioned above, there are doubts about how safe Polyoxidonium really is for immunity. Instructions for use of the drug take them into account with the vague wording "rarely", and contain an indication of possible soreness along the entire length of the muscle fiber after the injection.

And she describes candles and pills as completely safe. But a number of skeptical experts point to other possible threats.

Cellular metabolism is 100% dependent on the normal structure and permeability of membranes. In particular, the high ability to change both parameters makes spread, a solid vegetable oil with an artificially added extra carbon chain, a carcinogenic product. If the azoximer bromide harms the metabolism of protective bodies in a similar way, it may be a catalyst for their malignant transformation. And the increase in the activity of resistance agents here is explained by the loss of functionality of a significant part of them (the bodies that have retained the ability to capture antigens are trying to compensate for their "disability").
The autoimmune reactions provoked by it, judging by indirect and not systematized data, are more common than indicated in the instructions. And with existing pathologies of this type, it is more likely not to be taken than vice versa.

The long-term effects of taking Polyoxidonium are unclear. And in the short term, the mechanism of its action, which remains a mystery to science, is equally likely to be an innovation or a placebo.

Instructions for use of the drug Polyoxidonium for immunity

The rules and regimen for taking Polyoxidonium for protection differ depending on the form of release chosen and the age of the patient.

Adults

Polyoxidonium for immunity for an adult is allowed at 6-12 mg per day, regardless of weight.

The easiest way is with suppositories - they are administered rectally, and in those who are sexually active, vaginal use is allowed. Scheme - 1 per day, at bedtime, a course of 10 days.
(from three years) prescribe 12 mg twice a day, 7-10 days, regardless of meals.
The lyophilisate is diluted with 1-2 ml of drinking water and allowed to swell. Its introduction into a vein is allowed - the entire dose at a time, after 1-3 days, with a course of up to 10 droppers.

children

Polyoxidonium for immunity for children from six months to 6 years is only dripped - into or under the tongue. The daily volume of the active substance is calculated at 0.15 mg/kg of body weight. The received dose is divided into a couple of doses.

The solution is made and dosed, as for adults, but administered drip (in the nose, under the tongue) or intramuscularly after 1-3 days, in series of 5-10 applications. Intravenous use is not indicated until adulthood.
Polyoxidonium tablets are given at 6 mg per day, for 2 doses of 0.5 tablets, a weekly course.
Candles (from six years old) are administered according to the schedule of adults, up to 10 days in a row.

Price and where to buy Polyoxidonium?

This immunomodulator belongs to the registry of vital and essential drugs (vital and essential drugs) formed at the state level in the Russian Federation.

Its production is sponsored from the budget, the cost and constant availability in pharmacies are monitored by the famous Ministry of Health. You can buy it everywhere, including the Internet:

the price of tablets fluctuates between 820-832 rubles;
candles will cost 950-1160 rubles. for 10 pcs. (depending on the concentration of the active substance);
powder for preparing a solution costs 1250-1300 rubles.

Analogues

Polyoxidonium has no analogues to strengthen the immune defense - neither domestic nor in the world. It is unique in its kind and is produced exclusively by NMC Petrovax Pharm LLC.

Azoximer bromide has a complex effect: immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory.

The detoxifying and antioxidant properties of Azoximer bromide are largely determined by the structure and high-molecular nature of the drug.

When administered orally, Azoximer bromide also activates lymphoid cells in the intestinal lymph nodes.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins, salts of heavy metals from the body, inhibits lipid peroxidation, both by intercepting free radicals and by eliminating catalytically active Fe2+ ions. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, has no mitogenic, polyclonal activity, antigenic properties, does not have an allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effect.

Azoximer bromide is odorless and tasteless, does not have a local irritating effect when applied to the mucous membranes of the nose and oropharynx.

Pharmacokinetics

Azoximer bromide after oral administration is rapidly absorbed from the gastrointestinal tract, the bioavailability of the drug when administered orally is more than 70%. The maximum plasma concentration is reached 3 hours after ingestion. The pharmacokinetics of Azoximer bromide is linear (plasma concentration is proportional to the dose taken).

Release form

Tablets from white with a yellowish tint to yellow with an orange tint, flat-cylindrical, with a chamfer, with a risk on one side and the inscription "PO" on the other side; the presence of barely noticeable inclusions of a more intense color is allowed.

Excipients: mannitol, povidone, betacarotene, lactose monohydrate, potato starch, stearic acid.

10 pieces. - cellular contour packings (1) - packs of cardboard.

Dosage

Use the drug only according to the indications, the method of application and in the doses indicated in the instructions.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Orally and sublingually 20-30 minutes before meals daily 2 times a day: children over 10 years old and adults - 1 tablet, children from 3 to 10 years old - ½ tablet (6 mg).

If necessary, it is possible to conduct repeated courses of therapy after 3-4 months. With repeated administration of the drug, its effectiveness does not decrease.

Sublingual:

For adult treatment:

flu and acute respiratory infections - 1 tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - 1 tablet 2 times a day for 10 days; exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis - 1 tablet 2 times a day for 10 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 10 days.

For the treatment of children from 3 to 10 years:

flu and acute respiratory infections - ½ tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - ½ tablet 2 times a day for 7 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - ½ tablet 2 times a day for 7 days.

flu and acute respiratory infections - 1 tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - 1 tablet 2 times a day for 7 days; exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis - 1 tablet 2 times a day for 7 days; allergic diseases (including hay fever, bronchial asthma) complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 7 days.

For prevention in adults:

influenza and acute respiratory infections in the pre-epidemic period - 1 tablet per day for 10 days; recurrent herpetic infection of the nasal and labial area - 1 tablet 2 times a day for 10 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1 tablet once a day for 10 days; secondary immunodeficiencies arising from aging or exposure to adverse factors - 1 tablet 1 time per day for 10 days.

For prevention for children from 3 to 10 years:

Influenza and acute respiratory infections in the pre-epidemic period - ½ tablet per day for 7 days; recurrent herpetic infection of the nasal and labial area - ½ tablet 2 times a day for 7 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - ½ tablet once a day for 10 days.

For prevention in children over 10 years of age:

influenza and acute respiratory infections in the pre-epidemic period - 1 tablet per day for 7 days; recurrent herpetic infection of the nasal and labial area - 1 tablet 2 times a day for 7 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear, 1 tablet once a day for 10 days.

oral

For adult treatment:

For treatment of children over 10 years of age:

diseases of the upper and lower respiratory tract - 1 tablet 2 times 10 days.

Interaction

If you are taking any of the above or other medicines (including over-the-counter medicines), talk to your doctor before taking Polyoxidonium.

Side effects

Side effects are not registered. If you notice any side effects that are not listed in the instructions, tell your doctor.

Indications

Treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology) that are not amenable to standard therapy in adults and adolescents over 12 years of age, both in the acute stage and in remission.

As part of complex therapy:

acute and chronic infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;
allergic diseases complicated by recurrent bacterial, fungal and viral infections (including pollinosis, bronchial asthma);
for the rehabilitation of often and long-term (more than 4-5 times a year) sick people.

As monotherapy:

prevention of recurrent herpetic infection;
seasonal prevention of exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;
in immunocompromised individuals for the prevention of influenza and other acute respiratory infections in the pre-epidemic period;
for the correction of secondary immunodeficiencies arising from aging or exposure to adverse factors.

Contraindications

increased individual sensitivity; pregnancy, breastfeeding period; children's age up to 3 years; acute renal failure; rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

Application features

Use during pregnancy and lactation

The use of the drug Polyoxidonium® is contraindicated in pregnant women and women during breastfeeding (clinical experience is not available).

In the experimental use of the drug Polyoxidonium® in animals, no embryotoxic and teratogenic effects or effects on the development of the fetus were detected.

Before using the drug Polyoxidonium®, if you are pregnant, or think that you could be pregnant, or are planning to become pregnant, you should consult your doctor.

During breastfeeding, before using the drug Polyoxidonium, you should consult your doctor.

About caution

If you have any of the conditions listed in this section, talk to your doctor before taking this medicine: chronic renal failure (use no more than 2 times a week).