Is it an analogue of duphaston. Consequences of overdosing
Infertility is dangerous diagnosis and a terrible sentence for every woman who sees her future in happy motherhood. In the treatment of this disease, in some cases, the question arises of what can replace Duphaston, but what is the reason for this?
The essence of the problem
Before talking about correction hormonal regimen treatment, it is necessary to recall that Duphaston has practically no contraindications, and is approved for use by all women, with the exception of patients with increased intolerance to the active components. Such cases are extremely rare, but nevertheless, in practice, obstetrics have been recorded more than once. In addition, it is worth noting that this particular drug does not always help in the treatment of infertility, for example, six-month therapy with low efficiency requires immediate correction.
If the problem is ovulation or her total absence, then the female body needs additional progesterone, which is produced in enough. That is why it is required to additionally take Duphaston or another analogue for the timely regulation of hormonal levels, menstrual cycle and successful ovulation.
Worthy analogue
Many patients ask the standard question, is it possible to replace Duphaston with Utrozhestan? Most often, the answer is yes, since the characteristic drug has a similar composition, pharmacological effects to the site of pathology. But what is known about this medical preparation? Unlike Duphaston, progesterone in chemical formula not synthesized, but presented in in kind which increases the chances of successful conception.
The use of a characteristic medication is appropriate not only in obstetrics, but also in modern gynecology, and among the indications, not only diagnosed infertility is distinguished, but also others no less dangerous diseases. Among those are the following:
- threat and prevention of miscarriage;
- menopause and climate syndrome;
- mastopathy of the mammary glands;
- premenstrual syndrome;
- disturbed menstrual cycle;
- endometriosis and its prevention;
- prevention of uterine fibroids.
Contraindications and side effects
Utrozhestan gently acts in the female body, and among the contraindications, the instructions indicate hypersensitivity and lactation. It is also not recommended to take the drug with a tendency to uterine bleeding, if you suspect malignant neoplasms, as well as in the case of impaired blood clotting. This is where the list of restrictions ends, but side effects are quite common, and on numerous sites on the network, patients reflect in detail all their dissatisfaction with such an appointment.
Most often, anomalies prevail at the very beginning of the intake, when the body is just getting used to an additional source of progesterone, and is not always ready for such radical changes. Doctors distinguish the following anomalies that progress in especially weakened organic resources:
- frequent dizziness, less often - fainting;
- increased drowsiness;
- nervous excitement;
- skin rash;
- headache attacks, migraine;
- angioedema;
- hemolytic anemia;
- hives and itching;
- passivity and decline in performance;
- distracted attention;
- signs of dyspepsia;
- depressed state.
If there are characteristic anomalies, you should not rush to stop the drug, perhaps a dose adjustment is enough to achieve positive dynamics of the disease. Otherwise, a replacement will be required, and the effect of a new analogue in the body is the most unpredictable.
Dosage and administration
the medical preparation available in the form of capsules intended for oral and vaginal application. One pill contains 100 mg of natural progesterone, but the method of application is discussed individually by the attending gynecologist.
In order to prevent a particular diagnosis, the specialist recommends internal reception hormone, and the prescribed daily allowance is very important to maintain. If this is a treatment for diagnosed infertility, then doctors also stop at oral administration Utrozhestan. But to maintain pregnancy with a threat of miscarriage, it is preferable vaginal use capsules, but internal intake in the complex also does not hurt.
Utrozhestan has a lot of advantages, and such advantages are hard to deny. For example, with early toxicosis of a pregnant woman, it is better to insert the capsules vaginally, and the therapeutic effect is identical. Besides, sedative effect has a positive effect on the excited nervous system and progesterone also helps eliminate congestion in the female body.
It is very important that the drug corresponds to the expiration date, and was prescribed by a doctor, and not by a girlfriend following her example. The effectiveness is noticeable after 2-3 months of regular use, however, each patient has her own individual characteristics of treatment.
Other analogues
If, according to the indications, Duphaston is suitable, but contraindications limit its systematic use, then in addition to the hormonal drug Utrozhestan, there are other sensational analogues that are also effective in the presented clinical pictures. But what kind of drugs are we talking about?
Most often, these are such names as Utrozhestan and Prajistan, which are considered a worthy alternative with a sufficient amount of synthetic progesterone necessary to correct the menstrual cycle, hormonal levels and provide successful conception. These drugs are patented in Russia, are widely used in gynecological and obstetric practice, show a stable therapeutic effect even in seemingly hopeless clinical situations.
If the medical drug Duphaston is not suitable, the patient should not engage in superficial self-medication, since the positive dynamics of the underlying disease will still not wait. First of all, you need to contact a specialist, and that clinically will select the most effective replacement, a worthy analogue. There is no complete analogue of the characteristic medicines, and it is important not to forget about this when correcting the treatment regimen.
It remains only to add that all the presented medicines have a hormonal basis, that is, they have a direct effect on hormonal background. That is why one should not exclude such anomalies as unexpected weight gain, increased vegetation on the body. It is important to note this question in order to keep the form, presentable appearance. However, such cases are very rare, so the patient may not worry about common fears in terms of taking "hormones".
If the hormonal drug Duphaston is categorically contraindicated for use, only the attending gynecologist will tell you how to replace such an appointment. If such a replacement is required when carrying a fetus to preserve its viability, then this should definitely be the Utrozhestan medication, which is dispensed without an additional prescription. The characteristic preparation can be taken orally and vaginally, which will markedly enhance the desired therapeutic effect.
It's no secret that every year the state environment significantly worsens, which adversely affects the health of people. Without the help of medicines, many women cannot conceive and carry a child. But science does not stand still: there are many drugs that not only increase the likelihood of a desired pregnancy, but also lead to normal women Health. One of these medical "helpers" for the fair sex is the Duphaston remedy. But not only this drug helps to restore hormonal balance female body and allows you to make the dream of a crumb come true. The doctor can also prescribe an analogue of Duphaston, and more than one. But which one is better - let's try to figure it out.
Why is Duphaston so good?
Before considering which drug can be a worthy alternative to this medicine, you should understand what properties it has and how it affects the woman's body.
So, dydrogesterone, which is the basis of the drug, according to molecular structure, pharmacological and chemical properties close to natural progesterone. It is the deficiency of this hormone that can deprive a woman of the joy of motherhood. Despite the fact that it is a derivative of testosterone, side effects hormone does not. It is worth noting that this characteristic is a huge benefit of the drug. This cannot be said about many synthetic progestogens, which are necessary components of hormone replacement therapy. Among other things, the drug does not affect the metabolism of carbohydrates and the functioning of the liver, its action does not affect the processes of ovulation and metabolism.
Pharmacokinetics
A feature of the drug "Dufaston" is that it quickly gets out of gastrointestinal tract in bloodstream. The maximum concentration in the blood after taking the tablets is observed after 2 hours. Further, 97% of dydrogesterone binds to proteins and is hydroxylated in the liver cells.
results clinical research confirm that about 64% of the dydrogesterone dose is excreted naturally, with urine. Thanks to this, it becomes possible to determine the endogenous level of progesterone. The instruction will help to obtain more specific information about the pharmacokinetics of the drug "Dufaston".
Analogues of the drug do not have the properties mentioned above.
Indications for use
Before considering the medicines that can replace the drug "Duphaston", you should figure out what women's problems it is prescribed for.
Most often, doctors recommend taking Duphaston medicine to women who have been diagnosed with a progesterone deficiency. The low level of this particular hormone in a woman's body is the cause of many troubles, such as the threat of fetal loss, menstrual irregularities, dysmenorrhea, premenstrual syndrome, infertility, secondary amenorrhea, dysfunctional uterine bleeding.
With all of the above ailments and conditions, doctors do not prohibit taking an analogue of Duphaston tablets, but if the budget allows, they recommend using the original drug.
How to replace the tool "Dufaston"?
To date, the most famous and most commonly used drug, which can fully replace the drug "Dufaston", is "Utrozhestan". But, fortunately, scientists did not stop at the development of only this drug. Therefore, today a woman who wants to conceive and safely bear a baby can acquire the most suitable option from a wide range of drugs. Of course, it is worth noting that this choice should be made entirely by the doctor, taking into account individual characteristics female patients. But situations in life are different, therefore, after consulting with a pharmacist, you can independently purchase a worthy analogue of Duphaston.
The drug "Urozhestan"
The drug "Utrozhestan" is produced on the basis of vegetable raw materials diogenin - a Mexican plant, better known as wild yam. It has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity. Also, this Russian analogue of "Duphaston" has a sedative effect that is useful for pregnant women, while it does not predispose to weight gain and does not affect the removal of fluid from the body.
Advantages and disadvantages of the drug "Utrozhestan"
A distinctive negative characteristic of this drug is a significant number of side effects that are not observed when using Duphaston tablets. This may be increased fatigue, dizziness, drowsiness, general malaise, distraction and other reactions.
But it should be noted that the above side effects fully compensate for the advantageous characteristics of the drug. So, the medicine "Utrozhestan" can be used both orally and intravaginally. This allows you to prescribe the drug not only to pregnant women with early toxicosis, but also to achieve the maximum therapeutic result in the development of other pathologies in expectant mothers.
Attribute to the benefits of the drug can be its cost. After all, this analogue of "Duphaston" is an order of magnitude cheaper than the original. But it is worth recalling that it is strictly forbidden to replace the prescribed medicine on your own. Therefore, before buying this more affordable medication, you need to consult with your doctor, especially if we are talking about maintaining the desired pregnancy.
Means "Dydrogesterone"
Like the drug "Dufaston", its analogues make up for the deficiency of progesterone in a woman's body. In particular, the drug "Dydrogesterone" helps to maintain the beneficial effect of estrogens on lipid profile blood. The active substance of the drug does not affect coagulation parameters, as well as carbohydrate metabolism and liver function. In addition, the advantages of the drug include the absence of androgenic, estrogenic, thermogenic, corticoid or anabolic activity.
To date, the tool "Dydrogesterone" is a good and affordable Russian analogue of "Duphaston". This synthetic progestogen is indicated for endogenous progesterone deficiency.
Means "Prajisan"
This modern analogue"Duphaston" is hormonal agent with progesterone. It is used in the treatment of long-term infertility, as well as insufficiency of the luteal phase. Effective at various violations menstruation cycle, premenopause, fibrocystic mastopathy and other ailments.
Since the drug has a wider spectrum of action than Duphaston, it is used only before pregnancy. Exceptions are cases where the benefit to the mother's body exceeds possible risk negative impact to the fruit.
What is the best analogue?
Only doctors have the right to talk about what medicine can replace Duphaston. Analogues of the drug are selected by a professional, taking into account all the individual characteristics of the patient and the complexity of her disease. Self appointment drugs of this group can harm the health of both the mother and the baby, and sometimes cause spontaneous abortion (with a sharp withdrawal of the remedy).
Name:
Duphaston (Duphaston)
Pharmacological
action:
Dydrogesterone, which is the active substance of duphaston, - progestogen analogue of natural progesterone. It has no estrogenic, androgenic, corticoid effect. Does not change thermogenesis, so the presence of ovulation can be established by monitoring basal body temperature body. Does not affect metabolism. There are no side effects associated with the use of synthetic progestins. Effective when taken orally. Selectively affects the progestin receptors of the uterine mucosa. Causes normal secretory transformations in the endometrium in case of sufficient estrogen saturation. Does not affect the ovulation of the follicle. It does not have a virilizing and / or masculinizing effect (including on the fetus).
After oral intake rapidly absorbed from the gastrointestinal tract. The maximum concentration in the blood after administration is observed In 2 hours. 97% of dydrogesterone binds to blood proteins. Hydroxylated in liver cells. Elimination of biotransformation products occurs in the urine (56-79%). 72 hours after a single dose, it is completely eliminated from the body. It does not accumulate, there is no increase in the concentration of dydrogesterone in patients with renal insufficiency.
Indications for
application:
Confirmed deficiency of endogenous progesterone(endometriosis, luteal insufficiency, habitual fetal loss or threatened abortion, premenstrual syndrome, menstrual irregularities, secondary amenorrhea, dysmenorrhea).
substitution hormone therapy
(surgical castration, including with a preserved uterus; menopausal syndrome - is used if it is necessary to neutralize the proliferative effect of estrogens on the mucous membrane of the uterine cavity when using estrogens for HRT).
Mode of application:
Destination schemes are indicative. For maximum therapeutic action should be considered Clinical signs diseases and phases of the natural menstrual cycle. Daily dosage divided into several doses, preferably at regular intervals.
At endometriosis apply 10 mg of dydrogesterone 2-3 r / s (without interruptions or from the 5th to the 25th day of the menstrual cycle).
At infertility progesterone genesis 20 mg / day (in 2 doses) from the 11th to the 25th day of the MC inclusive. The course of treatment is 3-6 months. If the patient becomes pregnant, treatment should be continued at the dose recommended for habitual loss pregnancy. The dose of dydrogesterone allows you to adjust cytological examination vaginal epithelium (colpocytology).
Habitual pregnancy loss and threatened abortion- used only in case of evidence of endogenous progesterone deficiency.
With threatened abortion apply 40 mg of dydrogesterone as a starting dose 1 time, then - 10 mg every 8 hours for 1 week. After that, the dosage is gradually reduced. However, with the resumption of signs of threatened abortion, it is possible to increase the dose again. Can be used up to 12-20 weeks of pregnancy.
With the usual miscarriage therapy is started when planning pregnancy: 10 mg 2 r / s from the 11th to the 25th day of the menstrual cycle. If conception has occurred, therapy is carried out at the same dose constantly, from the 20th week of pregnancy, the dose is gradually reduced. Clarification of the need to increase or decrease the dosage of dydrogesterone is possible after a colpocytological study.
With premenstrual syndrome(PMS) - 10 mg from the 11th to the 25th day of the menstrual cycle. The duration of therapy is 3-6 months.
With dysmenorrhea - 20 mg / s in 2 doses from the 5th to the 25th day of the menstrual cycle, for 3-6 months.
With an irregular menstrual cycle due to a short luteal phase, 20 mg / day is used, in 2 divided doses from the 11th to the 25th day of the cycle.
In the treatment of amenorrhea used in combination with estrogen. Apply 10 mg of dydrogesterone 2 times a day from the 11th to the 25th day of the menstrual cycle while taking 0.05 ethinylestradiol from the 1st to the 25th day of the cycle. The duration of treatment is 3 or more menstrual cycles.
For dysfunctional bleeding used at a dose of 10 mg 2 times a day for 5-7 days in combination with ethinyl estradiol 0.05 mg (this regimen stops bleeding). For prevention, 10 mg of dydrogesterone 2 r / s is used from the 11th to the 25th day of the menstrual cycle, combined with 0.05 ethinylestradiol 1 r / s.
As HRT used only in combination with estrogens.
With continuous therapy, 10 mg is used for 14 days each menstrual cycle. With cyclic use - only in the last 12-14 days of estrogens, 10 mg 1 r / s. If necessary (insufficient secretory transformation of the endometrium, confirmed by ultrasonography or histologically), the dose is increased to 20 mg / day.
Side effects:
Rarely- breakthrough bleeding. In this case, the dose of dydrogesterone must be increased. There may also be individual hypersensitivity to the drug.
Contraindications:
Undiagnosed vaginal bleeding;
- existing severe liver disease or the presence of serious illnesses liver in the past, if liver function indicators have not returned to normal;
- the use of estrogens in combination with progestogens, such as dydrogesterone;
- established hypersensitivity to active substance or to any other component of the drug;
- established or suspected neoplasms dependent on sex hormones.
Interaction
other medicinal
Most patients need long-term use medicines, sometimes it is not possible to buy a drug in sufficient quantities to pass full course, which forces them to look for cheap analogues of Duphaston. But are there any? And if so, how do they correspond to the prescribed remedy?
Duphaston (Duphaston)- common in gynecological practice a drug containing a synthetic analogue of progesterone (a hormone responsible for normal flow pregnancy) and used for:
- endometriosis;
- disorders of the menstrual cycle (dysmenorrhea, secondary amenorrhea);
- infertility resulting from luteal insufficiency;
- uterine bleeding;
- menopause or similar disorders of the female reproductive system as a means of replacement therapy;
- premenstrual syndrome.
Criterias of choice
Analogues of the drug Duphaston should not only differ from it in price (downwards), but also have the same spectrum therapeutic activity(treat for the same or most of the diseases indicated in the instructions for its use). However, they may not be absolutely identical and may not contain a similar active ingredient. Therefore, when reviewing medicines we will divide them into two conditional groups.
Necessary warning: all of the "Duphaston substitutes" listed below, despite the fact that data from reliable sources were used in their search, in no case replace the recommendations of the attending physician and do not cancel his appointments. And therefore, if it is necessary to change the drug to one of those provided in this article (except for the cases specified), we strongly recommend that you notify the specialist and undergo additional consultation in order to prevent the occurrence of possible complications.
Identical preparations
Full analogues of Duphaston are:- Dufaston;
- Dydrogesterone.
Dufaston: most likely this drug was just released a little later than the other pharmaceutical company. The only possible difference from the fixed asset is in the price, which can be either lower or higher (depending on the place of sale). Possible differences: slight difference in additional components.
Dydrogesterone: the active component of the fixed asset in pure form. The most complete and reliable analogue of tablets, and its price is several times lower than that of Duphaston. However, do not rush to rejoice: it is so rare in pharmacies that it is almost impossible to find it. This is especially true for small towns in remote regions. As for additional components, then their list is minimal and, most likely, they serve only to form a dosage form.
Means with a similar effect
This group includes preparations containing active ingredients similar to progesterone. All of them can be used to treat diseases listed in the indications for Duphaston.Utrozhestan(Utrogestan) is an analogue of Duphaston from Thailand, which contains natural micronized progesterone obtained from volunteers or animals as an active ingredient. Hence, more high efficiency and relatively low probability of occurrence allergic reactions(hormones do not contain an antigenic structure and act equally well in various kinds animals). But at the same time, the drug is contraindicated in case of bleeding from birth canal women of unknown origin and can cause drowsiness, which is why it is contraindicated for those who are busy active species activities or driving vehicles.
Progesterone(Progesterone) - the Russian analogue of Duphaston, containing a progestogen - a hormone corpus luteum. Despite the clear difference in active component, it is used in the same cases as the main drug. A significant difference is that the latter is produced exclusively in dosage form for injection, which makes it somewhat difficult independent application which allows it to be used in the hospital. But on the other hand, it leads to achievement much faster. therapeutic effect than tablet forms and, as a result, can become the drug of choice for especially severe forms spontaneous abortion.
What we have
Small list available analogues, which may still provide some choice for buyers:- Dufaston;
- Dydrogesterone;
- Utrozhestan;
- Progesterone.
Duphaston is a drug, a substitute for natural progesterone (the main active substance- dydrogesterone).
The drug is prescribed for deficiency of the specified female hormone(regardless of the cause of the problem). Dufaston selectively affects the endometrium, does not affect metabolism, does not affect liver function.
Indications for the use of the drug
- endometriosis (an abnormal growth epithelial tissue lining inner surface uterus);
- infertility caused by a deficiency of progesterone in the body;
- unstable menstrual cycle;
- uterine bleeding.
Release form Duphaston - tablets (10 mg). The cost of funds ranges from 491 to 671 r. Take the medicine orally in the dosage selected by the doctor.
Taking the drug is associated with a number of side effects - migraines, minor malfunctions of the digestive tract, hypersensitivity mammary glands, general malaise, jaundice skin, systemic and local allergic reactions.
Despite this, Duphaston is rightfully recognized as one of the safest and most affordable (albeit expensive) drugs in its pharmacological group.
Please note: when individual intolerance patients individual components Duphaston, there is a need to select a drug - an analogue with similar clinical properties.
How to replace the medicine
Pharmacies sell cheaper medicines - analogues of Duphaston of Russian and foreign production.
Domestic analogues
Consider effective domestic medicines.
Progesterone
The average cost is 578 rubles. Hormonal drug, whose main task is to create the maximum comfortable conditions for the maturation of a fertilized egg.
Release form - solution in ampoules, intended for intramuscular injections.
pregnin
Price from 450 rubles. Synthetic substitute for the female hormone progesterone, has a positive effect on the structure of the endometrium, reduces the tone of the uterus during pregnancy. Available in tablets.
injesta
Most cheap analogue Duphaston, his price in a pharmacy - from 95 rubles. The main component is progesterone. The drug is prescribed to patients with amenorrhea, uterine bleeding, infertility.
Foreign substitutes
Analogues of Duphaston of foreign production.
Utrozhestan 
From 300 rubles/pack. The most accurate, cheaper "copy" of the Belgian-made study drug. Available in the form of capsules, suppositories, used orally and intravaginally.
Despite the moderate cost, Utrozhestan is inferior in popularity to Duphaston due to a wide range side effects.
So, with regular use of the drug, patients may experience dizziness, increased fatigue, weakness, drowsiness, general malaise.
Reviews about the drug are as follows.
Iprozhin
The price in a pharmacy is from 381 rubles / pack. The drug is co-produced by France and Italy. Refers to drug group gestagens. Good clinical effect demonstrates in the treatment of endometriosis, in the fight against PMS, mastopathy. Iprozhin is prescribed to patients who are about to undergo an IVF procedure (to prepare the uterus for bearing a fetus).
Crinon
From 2565 rubles. Effective gel British and German made. Used intravaginally, provides additional "release" of the vaginal mucosa of the hormone progesterone.
Prajisan
From 325 rubles. Indian capsules based on progesterone, soy lecithin and peanut butter. Effective and safe analogue Duphaston.
Megeis
The expensive American analogue of Duphaston (from 2700 rubles) based on megestrol, is available in tablets. Belongs to the drug group of gestagens, shows good clinical effect in the fight against endometrial cancer and anorexia.
Criterias of choice
Absolutely identical in composition and properties to Duphaston pharmaceutical preparations does not exist.
