Postinor analogues are safer. Instructions for use and method of use

Today, there are many contraceptives to prevent pregnancy. And, despite this, not all women choose this method of protection. But there are times when you need to resort to emergency assistance, and postinor can be such help. Postinor is like a pill next day and if you have had unprotected sex, then you can protect yourself with her.

Postinor is a hormonal contraceptive drug, which contains high dose the hormone levonorgesterel, the main active ingredient. With its help, ovulation is stopped, preventing sperm from reaching the egg.

The most known analogues Postinora are:

Escapelle;
Microlute;
Genale;
Eskinor-F;
Gynepristone;

Such analogues and postinor cannot be considered a contraceptive, since their effect is a little different from the real ones contraceptives. They are not designed for constant use, since with frequent use the structure of the endometrium changes, and in some organs they appear side effects, at long-term use addiction occurs and the effect of the drug decreases, it may even open uterine bleeding. Based on this, Postinor and analogues are recommended to be taken only in in case of emergency: in case of accidental unprotected sexual intercourse, if the condom breaks, rape and other unforeseen cases.

What to take - postinor or analogues?

If you cannot take the drug after individual intolerance, contraindications to the use of any of the components or its absence in the pharmacy, then you can. Girls think that after taking postinor analogues there will be no consequences and if there are any, they will be insignificant. But they are mistaken, just like they have a large number of levonorgesterel, which means they are not inferior to Postinor in terms of the number of side effects.

Among such drugs, Postinor was launched earlier than anyone else, and after taking it, women experienced nausea. And during pregnancy, it can have a negative effect on her. Postinor analogues act in exactly the same way. Although there are some differences.

For example, analogue of Escapelle created later and doesn't have as much side effects, and you can take it a little longer than Postinor. Generally speaking, all new drugs have more effect and are not so harmful.

But if you compare analogue of Ginepriston with Postinor, they are very similar in side effects. Gynepristone also causes nausea, vomiting, discharge and even disrupts the menstrual cycle. When taking one of these drugs, weakness, dizziness, urticaria, and hyperthermia often occur. For these reasons, taking Postinor and analogues without a doctor’s prescription is not recommended, as the consequences can be very serious.

1 tablet contains 750 mcg , as well as colloidal anhydrous silicon dioxide, magnesium stearate, potato and corn starch, talc, lactose monohydrate.

Release form

Tablets packaged in blisters of 2 pcs. The package contains 1 blister.

Contraceptive pills Postinor are flat, approximately 6 mm in diameter, with a bevel, almost white, on one side they are engraved with the inscription “INOR”.

pharmachologic effect

The drug helps prevent pregnancy and causes effects in the body similar to those of hormones corpus luteum ovaries, and also suppresses the effects caused .

Pharmacodynamics and pharmacokinetics

What is Postinor?

Postinor is a remedy with a pronounced antiestrogenic And progestogenic activity. These properties of the drug make it difficult to conceive early stage and help prevent pregnancy.

Pharmacodynamics

It is not known exactly how Postinor works. Contained in tablets levonorgestrel prevents ovulation and fertilization of the egg if UPC (unprotected sexual intercourse) occurs before ovulation (when the probability of fertilization is highest).

Levonorgestrel also causes changes in the endometrium, which make it difficult for a fertilized egg to penetrate the mucous layer of the uterine cavity. In cases where attachment ovum has already started, the drug does not give the expected effect.

Wikipedia states that the mechanism of action levonorgestrel is most successful when the size of the dominant follicle is 17 mm. Best of all, the drug suppresses ovulation no later than three days before it.

Efficacy of tablets

The probability of pregnancy after the use of Postinor tablets is 15-42%. The action after taking the better, the less time has passed after NPC.

If the drug was taken within 24 hours, its effectiveness is 95%, in the next 24 hours it decreases to 85%, on the third day - to 58%. It makes no sense to take the drug later than 72 hours later.

Is Postinor harmful?

Pharmacokinetics

Absorption in the alimentary canal when ingested is rapid and complete. In the body, the drug binds to SHBG and albumin: approximately 65% dose taken associated with SHBG, in free form is only 1.5%.

96 minutes after taking the tablet, the plasma concentration levonorgestrel reaches 14.1 ng/ml. Then there is a 2-stage decrease in Cmax.

The drug is well distributed in tissues and organs.

Its biotransformation occurs in the liver. The resulting metabolic products (conjugated glucuronates) are pharmacologically inactive.

Levonorgestrel excreted from the body exclusively in the form of metabolic products. About half of the dose taken is excreted in the urine, the rest in feces. The value of the T1/2 indicator varies from 9 to 14.5 hours.

With milk into the body baby When taken by a nursing woman, Postinor reaches about 0.1% of the dose.

Indications for use

“Emergency” contraception in case of failure of the chosen method of contraception or after NPC.

Contraindications

A contraindication to the use of the drug is intolerance levonorgestrel or any of the auxiliary ingredients contained therein.

The drug is used in pediatric practice. Data regarding its use in girls under 16 years of age are limited, therefore Postinor is not recommended for use in adolescence without medical supervision.

Side effects of Postinor: why is the drug dangerous?

In the annotation for the drug, the manufacturer reports that the most common reaction to the use of levonorgestrel is nausea .

In addition, the following side effects of Postinor were recorded during the studies:

dizziness;
headache;
And vomit ;
nausea;
not related to the menstrual cycle ;
failure menstrual cycle(namely, a delay in menstruation after taking the pill for more than a week);
increased fatigue.

Post-marketing observations have shown that sometimes (rather rarely) the use of the drug may be accompanied by: hypersensitivity reactions ( , the appearance of skin rashes, skin itching), , pain in the pelvis and / or in the abdomen, swelling of the face.

Why is Postinor harmful?

Reviews of side effects allow us to conclude that, according to women, the most unpleasant phenomena after taking Postinor are:

bleeding (in some reviews it is mentioned that, not knowing how to stop the bleeding after Postinor, the woman was forced to seek medical help);
strong hormonal disbalance and severe cycle disorders (many cases have been described when, after taking Postinor, there are no periods for several cycles; for some, it takes up to a year to restore the regularity of menstruation).

This list can include the appearance of "male" signs, metabolic disorders And acne .

Sometimes the consequences of taking the Postinor tablet manifest themselves in the form of miscarriage of subsequent pregnancies and infertility.

To minimize harm to the body, the drug should be used no more than 3-4 times a year.

Postinor tablets: instructions for use

How to take Postinor?

The instructions for Postinor indicate that contraceptive effect is provided by taking two tablets (provided that the first tablet is taken in the first 3 days after NPC). A twelve-hour interval is maintained between doses 1 and 2.

If within 3 hours after taking the drug (regardless of whether 1 or 2 doses), you should immediately take another 750 mcg levonorgestrel (3rd tablet).

The product can be used in any phase of the menstrual cycle. Required condition is the absence of a woman’s delay in menstruation.

After taking the pills, before the start of your next period, it is recommended to use barrier contraception (cervical cap or condoms).

Taking the drug is not a contraindication for continuing the use of hormonal agents for regular contraception.

How can you tell if the drug has worked?

The tablet begins to act immediately after dissolution and absorption in the intestinal tract.

Evidence that the drug has “worked” is menstruation.

Bleeding after use rules out pregnancy in approximately 95-85% of cases if it begins 3-6 days after taking the pill.

What might a delay after Postinor indicate?

If after using the drug there is no bleeding or bleeding begins later than the specified period, the woman is recommended to undergo a gynecological examination to rule out pregnancy.

You should consult a doctor not only if your period is late, but also if, after taking Postinor, the consequences are expressed in the form of bleeding that is unusually heavy for a woman. The causes of such bleeding may be exceeding the recommended dose and Negative influence levonorgestrel on endometrium of the uterus .

Sometimes women note that they have brown discharge after taking it. The phenomenon is considered normal if the discharge appears within a few days, thus ending the menstruation artificially induced by the pills. However, for some women, spotting may continue for up to a month.

Most likely this is individual reaction on severe stress for the reproductive system, but only a doctor can accurately diagnose the cause of the discharge.

Causes for concern are menstrual bleeding lasting more than 14 days, lack of full periods, the appearance of clots or heavy brown discharge, pain.

When should I get my period after taking the pill?

It is impossible to say exactly when your period will begin after using Postinor. The tablets contain a large amount levonorgestrel , therefore, even a single use of the drug does not leave its mark on the body.

In most cases, after taking the drug, the menstrual cycle remains the same. Sometimes bleeding may begin earlier or slightly later. Normally, the delay should not be more than 5-7 days. Otherwise, pregnancy should be excluded.

After taking levonorgestrel a woman is recommended to visit a doctor who will help her choose the most suitable method regular contraception.

Is it worth taking Postinor if NPK occurs during menstruation?

In women with irregular cycle there is a chance of getting pregnant even during menstrual bleeding. The advisability of using “urgent” contraception if UPC occurred during menstruation can be determined by a doctor.

How often can you take Postinor?

To the question “How often can you take emergency contraceptive pills?” Doctors answer that drugs like Postinor are not intended for systematic use. They are used only in emergency situations and no more than 3-4 times a year.

Overdose

Clinical picture of overdose hormonal agents emergency contraception not described. Most likely, the first signs of poisoning will be nausea and breakthrough bleeding.

Postinor does not have a specific antidote.

Interaction

In combination with liver enzyme inducers, there is an increase in metabolism levonorgestrel .

The effectiveness of drugs that contain levonorgestrel , may decrease with simultaneous use With:

barbiturates ;
preparations of St. John's wort (Hypericum perforatum);
rafibutin ;
ritonavir ;
phenytoin ;

Women taking these drugs should consult their doctor before taking Postinor.

Levonorgestrel-containing drugs may cause increased toxicity , which is associated with a possible suppression of its metabolism.

Terms of sale

On prescription.

Storage conditions

Tablets should be stored at a temperature of 15-25°C.

Best before date

special instructions

“Emergency” contraception are intended for occasional use and do not replace a regular method of birth control.

“Emergency” contraception does not always prevent pregnancy. If there is any doubt about the CPD time or if unprotected act occurred more than 72 hours during the same cycle, the possibility that the fertilized egg has already implanted in the uterine wall cannot be ruled out.

In this regard, the use of tablets during the next sexual intercourse may be ineffective. If the cycle is delayed by more than 5 days, if atypical bleeding develops on the day of the expected menstruation, as well as if there are other reasons to suspect pregnancy, the fact of pregnancy should be excluded.

After taking levonorgestrel there is a risk of developing ectopic pregnancy . The absolute likelihood of this is low, since the drug interferes with ovulation and fertilization.

Ectopic pregnancy may persist despite the occurrence of uterine bleeding.

Most likely in women who noted fainting or severe pain in the abdomen, as well as if there is a history of surgery on fallopian tubes, , or PID .

Based on this, patients at risk are not recommended to take Postinor tablets.

Taking the pills may slightly change the pattern of bleeding, but in most cases the next menstruation begins a maximum of a week after the usual date.

If menstrual bleeding is delayed by more than 5 days, it is necessary to exclude the fact of pregnancy.

The drug should not be used by women with serious liver pathologies. The effectiveness of tablets may be negatively affected severe violations absorption (eg granulomatous enteritis ).

To those suffering similar diseases women before undergoing emergency contraception It is recommended to consult a doctor.

Postinor tablets contain lactose, which should be warned about in patients with lactase deficiency And disorders of glucose and galactose absorption .

The drug is ineffective as regular contraception and is not an alternative to it. You should also remember that this remedy does not replace necessary measures precautions related to protection against STD .

If a woman applies for repeated use of Postinor, the doctor should recommend that she use long term methods protection from pregnancy.

Research on Impact levonorgestrel on management ability vehicle or working with mechanisms were not carried out, but one should forget about the possibility of dizziness. Eskinor-F .

Which is better - Escapelle or Postinor?

Escapelle and Postinor are synonyms. The basis of both is levonorgestrel . Only in the first case its concentration is 1.5 mg/tablet, and in the second - 0.75 mg/tablet. That is Escapelle in the case of NPC, it should be taken once, and Postinor should be taken in 2 doses with an interval of 12 hours.

Which is better - Zhenale or Postinor?

Active substance Genale - synthetic antiprogestin . The substance is a derivative norethisterone and is used to terminate pregnancy early stages. Its content in each tablet is 10 mg.

Mifepristone is non-hormonal agent , which reversibly and transiently blocks exclusively peripheral PRs (receptors progesterone ). Depending on the phase of the menstrual cycle, the drug prevents the release of luteotropin , delays or blocks ovulation and causes disturbances in the transformation of the endometrium, which, in turn, complicates the implantation of the egg.

WHO data indicates that the use of low doses mifepristone more effective and safe than emergency contraception using levonorgestrel .

In addition, it has been experimentally proven that the contraceptive effect mifepristone does not decrease with increasing interval between NPC and administration Genale up to 120 hours. This is also a significant advantage of the latter over Postinor.

If necessary “urgent” contraception it is enough to take 1 tablet during the first 72 hours Genale . The drug is used 2 hours before meals.

What is better - Postinor or Ginepristone?

Active substance Gynepristone is also mifepristone at a concentration of 10 mg/tablet. Thus, the drug has the same advantages over Postinor as Genale .

The product has high efficiency, is characterized by the absence of significant side effects and can be used for occasional contraception in women with irregular sex life.

In addition, the drug is more affordable compared to Postinor. Its price in Russian pharmacies is approximately 100-120 rubles lower than the price of Postinor.

Postinor and alcohol

Is it possible to combine Postinor tablets with alcohol? There are no recommendations in this regard in the manufacturer's instructions.

However, it should be remembered that alcohol is not compatible with the vast majority of pharmaceutical products.

Drinking alcoholic beverages in combination with Postinor can cause a sharp dilation, and then an equally sharp constriction of blood vessels, which in turn will complicate the woman’s condition when the drug provokes rejection of the uterine mucosa.

In addition, alcohol increases the level of liver enzymes, thereby speeding up metabolism. And since biotransformation levonorgestrel is carried out in the liver, the contraceptive effect of Postinor while drinking alcohol can be very questionable.

Postcoital contraceptive. Gestagen

Active substance

Levonorgestrel

Release form, composition and packaging

Pills white or almost white, disc-shaped, chamfered, with circular engraving "INOR." on one side.

Excipients: colloidal silicon dioxide, potato starch, magnesium stearate, talc, corn starch, lactose monohydrate.

2 pcs. - aluminum/PVC blisters (1) - cardboard packs.

pharmachologic effect

Synthetic gestagen with contraceptive effect, pronounced gestagenic and antiestrogenic properties. With the recommended dosing regimen, levonorgestrel suppresses ovulation and fertilization if sexual intercourse occurs in the preovulatory phase, when the possibility of fertilization is greatest. It may also cause changes in the endometrium that prevent implantation. The drug is not effective if implantation has already occurred.

Efficacy: with the help of Postinor tablets, pregnancy can be prevented in approximately 85% of cases. The more time passes between sexual intercourse and taking the drug, the lower its effectiveness (95% during the first 24 hours, 85% from 24 to 48 hours and 58% from 48 to 72 hours). Thus, it is recommended to start taking Postinor tablets as soon as possible (but no later than 72 hours) after sexual intercourse, if no protective measures have been taken. At the recommended dose, levonorgestrel does not have a significant effect on blood clotting factors, fat and carbohydrate metabolism.

Pharmacokinetics

Suction and distribution

At orally Levonorgestrel is rapidly and almost completely absorbed. Absolute bioavailability is almost 100% of the dose taken. After taking 750 mcg of levonorgestrel, Cmax in serum equal to 14.1 ng/ml is achieved after 1.6 hours. After reaching Cmax, the content of levonorgestrel decreases. T 1/2 is about 26 hours.

Metabolism and excretion

Levonorgestrel is excreted approximately equally by the kidneys and through the intestines exclusively in the form of metabolites. The biotransformation of levonorgestrel corresponds to the metabolism of steroids. Levonorgestrel is hydroxylated in the liver, metabolites are excreted in the form of conjugated glucuronides. Pharmacologically active metabolites of levonorgestrel are unknown. Levonorgestrel binds to serum and sex hormone binding globulin (SHBG). Only 1.5% of the total dose is in free form, and 65% is associated with SHBG.

Indications

- emergency (postcoital) contraception (after unprotected sexual intercourse or unreliability of the contraceptive method used).

Contraindications

— increased sensitivity to the components of the drug;

— adolescence up to 16 years old;

- pregnancy;

- rare hereditary diseases, such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Carefully: diseases of the liver and biliary tract, jaundice (including history), lactation.

Dosage

The drug is taken orally. You must take 2 tablets in the first 72 hours after unprotected intercourse. The second tablet should be taken 12 hours (but not later than 16 hours) after taking the first tablet.

To achieve a more reliable effect, both tablets should be taken as soon as possible after unprotected intercourse (no later than 72 hours).

If vomiting occurs within 3 hours after the 1st or 2nd dose of the Postinor tablet, then another Postinor tablet should be taken.

Postinor can be used at any time of the menstrual cycle. In case of irregular menstrual cycle, pregnancy must first be excluded.

After taking emergency contraceptive before the onset next menstruation local barrier should be used contraceptive methods(eg condom, cervical cap). The use of the drug during repeated unprotected sexual intercourse during one menstrual cycle is not recommended due to an increase in the frequency of acyclic spotting/bleeding.

Side effects

Allergic reactions: possible - urticaria, rash, itching, swelling of the face.

Transient side effects that occur with different frequency and not requiring drug therapy: very often (≥1/10), often (≥1/100,<1/10)

From the reproductive system: very often - pain in the lower abdomen, acyclic spotting (bleeding); often - soreness of the mammary glands, delayed menstruation (no more than 5-7 days, if menstruation is delayed for a longer period, it is necessary to exclude pregnancy).

From the digestive system: very often - nausea; often - vomiting, diarrhea.

From the nervous system: often - dizziness, headache.

Others: very often - fatigue.

Overdose

Symptoms: increased severity of side effects.

Treatment: there is no specific antidote. Symptomatic therapy is carried out.

Drug interactions

When taking drugs that induce liver enzymes simultaneously, the metabolism of levonorgestrel is accelerated.

The following drugs may reduce the effectiveness of levonorgestrel: amprecavil, lansoprazole, oxcarbazepine, tacrolimus, topiramate, tretinoin, barbiturates including primidone, phenytoin and carbamazepine; preparations containing St. John's wort (Hypericum perforatum), as well as rifampicin, ritonavir, tetracycline, rifabutin, griseofulvin.

Levonorgestrel reduces the effectiveness of hypoglycemic and anticoagulant (coumarin derivatives, phenindione) drugs. Increases plasma concentrations of GCS. Women taking these drugs should consult a doctor.

Drugs containing levonorgestrel may increase the risk of toxicity due to inhibition of its metabolism.

special instructions

Postinor should be used exclusively for emergency contraception. Repeated use of the drug Postinor during one menstrual cycle is not recommended.

The effectiveness of Postinor tablets after unprotected sexual intercourse, during which contraception was not used, decreases over time:

The drug does not replace the use of permanent methods of contraception. In most cases, Postinor does not affect the nature of the menstrual cycle. However, acyclic bleeding and a delay of menstruation for several days are possible. If menstruation is delayed by more than 5-7 days and its character changes (scanty or heavy discharge), pregnancy must be excluded. The appearance of pain in the lower abdomen and fainting may indicate an ectopic (ectopic) pregnancy.

Adolescents under 16 years of age, in exceptional cases (including rape), need to consult a gynecologist to confirm pregnancy.

After emergency contraception, a consultation with a gynecologist is recommended to select the most appropriate method of permanent contraception.

Emergency contraception does not protect against sexually transmitted diseases.

In case of gastrointestinal dysfunction (for example, Crohn's disease), the effectiveness of the drug may be reduced.

Impact on the ability to drive vehicles and machinery

The effect of Postinor on the ability to drive vehicles and operate machinery has not been studied.

Pregnancy and lactation

Postinor is contraindicated for use during pregnancy. If pregnancy occurs while using an emergency method of contraception, then based on the available data, no adverse effect of the drug on the fetus has been identified.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature of 15° to 25°C. Shelf life - 5 years.

Every year the number of women who clearly plan their lives increases: study, work, wedding and the birth of a child. The higher the goal, the longer pregnancy is postponed.

But, life often makes its own adjustments and after accidental unprotected sexual intercourse, an unwanted pregnancy is possible. To avoid this, the pharmaceutical industry offers emergency drugs. One of these is Postinor.

Postinor is produced by the Hungarian pharmaceutical company Gedeon Richter, which appeared on the market back in 1901. The company has been producing hormonal drugs since the sixties of the last century. All products are distinguished by their quality and excellent performance.

The drug contains levonorgestrel in a dosage of 75 mg and related ingredients. Two tablets, 75 mg each, on a silver blister.

Levonorgestrel is a hormone with a progestin effect, used for contraception. The main feature of the substance is its effect on the female reproductive organs, through:

increasing the thickness of the mucus secreted by the cervix, slowing down the movement of sperm;
changes in the mucosa, preventing the implantation of a fertilized egg;
blocking the ovulation phase, which is the most favorable time for conception.

When is Postinor used?

The main indication for the use of the drug is emergency contraception after unprotected coitus or in case of failure of other methods of protection.

In European countries, there is a practice of using levonorgestrel drugs in victims of rape or domestic violence.

Thus, medical workers are trying to reduce the number of abortions, which are harmful to the female body and prohibited by Western law.

To whom is it contraindicated?

Postinor is not used in women with hypersensitivity to levonorgestrel, which is expressed in redness of the skin, turning into an itchy rash. Use with caution in women with congenital lactose intolerance or a predisposition to blood clots.

Ladies suffering from chronic diseases of the liver, kidneys and gastrointestinal tract should remember that the drug is excreted through the intestines and bladder, and the transformation of levonorgestrel occurs in the liver.

Proper use is the key to the desired result

In order for Postinor to give the expected effect, you must strictly adhere to the instructions for use.

The optimal period for using Postinor is the next twelve hours after sexual intercourse or no later than seventy-two hours. This multiplicity guarantees effective contraception.

The first tablet should be taken as quickly as possible. The second is taken twelve hours after the first. If, three hours after consuming the drug, vomiting occurs, the dose must be repeated immediately to maintain the required concentration of levonorgestrel in the patient’s blood.

The use of Postinor is permissible at any period of the menstrual cycle, but with the obligatory condition: there should not be a delay in monthly menstruation. Subsequently, until the start of the next critical days, a barrier contraception method is used.

Why did you feel sick after taking the pill?

Since the exact mechanism of action of levonorgestrel-containing drugs is not precisely understood, it is impossible to say with certainty whether it can cause side effects or overdose.

Conducted studies confirm that while taking Postinor the following are possible:

general weakness, migraines and dizziness;
intestinal upset, pain in the lower abdomen, nausea, severe vomiting;
cycle disruption from five to seven days;
uterine hemorrhages, swelling of the mammary glands;
scanty bleeding.

Several cases of unusual reactions when taking hormonal drugs have been registered:

small rashes on the skin in the form of hives;
swelling of the face.

Overdose

Any drug can give different reactions in the body when taking the drug in an amount significantly exceeding the daily norm. Postinor is no exception.

The peculiarity of the progestin drug is that when taking a dose exceeding 1.5 mg, a woman may experience severe uterine bleeding or experience nausea and vomiting.

But this fact has not been reliably studied. Treatment for overdose is only symptomatic, since there is no antidote for the drug containing hormones.

Use of tablets during pregnancy and lactation

A special group of patients are nursing mothers and girls under the age of sixteen. This category of the population requires a more careful selection of medications.

In the case of teenagers, the situation is more clear. The body is not yet fully formed. During this period, hormonal changes occur, which can be mercilessly disrupted by taking prolactins.

Before the age of sixteen, obstetricians and gynecologists strictly prohibit abortions, because they can lead to subsequent infertility, menstrual irregularities and frequent diseases of the pelvic organs. If necessary, it is advisable to contact a specialist for qualified help.

For nursing mothers, the use of Postinor has several features. This is due to the fact that levonorgestrel passes into breast milk in an amount of at least one percent.

If there is a need for emergency contraception, experts advise either stopping breastfeeding for twenty-four hours, or breastfeeding the baby no earlier than eight hours after taking the pills. The main point is that the first tablet is taken after feeding.

Postinor will not cause any harm to expectant mothers and will not cause a miscarriage.

There are documented cases where women took the drug but remained pregnant. Levonorgestrel did not cause harm to the fetus.

The work of many drugs is based on the oxidation of molecules by certain enzymes in liver cells. There are a number of medications that, if used regularly, can reduce the productivity of hormonal drugs.

These include barbiturate-containing drugs, anticonvulsants (carbamazepine, thiopental), some antibiotics (rifampicin, rifabutin, griseofulvin), ritonavir, as well as herbal dosage forms that include St. John's wort.

Postinor should not be used by women who have used cytostatics. It increases their toxic effects on the body.

Worth remembering!

The main use of Postinor is emergency contraception. It cannot be used systematically, thereby disrupting hormonal levels and the reproductive function of the body.

For those who need to take such drugs constantly, you should think about visiting a gynecologist and selecting high-quality systemic contraceptives.

This method of protection will be more effective and less harmful.

In addition, prolactins are not a means of performing abortion at home. In case of overdose, they can cause bleeding, which will be dangerous primarily for the woman.

Price of the drug, its analogues

An interesting fact is that there are not many drugs with a similar composition on the pharmaceutical market. And in pharmacies you can find only a couple of items that will one hundred percent replace Postinor.

The drug itself is in the middle price segment. The cost can range from 300 rubles. up to 400 rub. depending on the region.

If the pharmacy does not have it, you can safely replace it with one of these drugs: Escapelle, Eskinor-F, Modell 911.

Levonorgestrel in this release form differs in dosage. The package contains one pill, with a dose of the hormone - 1.5 mg.

You need to take the medicine for three days after unprotected sexual intercourse. When using "Escapel" by a nursing mother, breastfeeding must be stopped for a day.

The price ranges from 380 rub. up to 500 rub.

"Eskinor-F"

The Indian manufacturer offers consumers levonorgestrel in two release forms:

"Eskinor-F" tab. No. 2 0.75 mg;
"Eskinor-F" tab. No. 1 1.5 mg.

In addition to emergency cases, it is prescribed for long-term use in cases of heavy and frequent uterine bleeding.

Average cost 400 rub.

"Model 911"

Form of production: tablet packaging, active ingredient content 1.5 mg. You need to drink it within three days after unprotected coitus.

For women during lactation, in order to reduce the risk of hormone influence, the next feeding should be done no earlier than eight hours later and only after pumping.

The average price is 350 rubles.

What are they saying?

Postinor has been used by more than one generation of women. Everyone has their own impression about this drug, and most importantly, obstetricians-gynecologists are ready to give their advice. Therefore, below we will consider reviews from doctors and patients.

It just so happened that I got married during my student years. My husband and I didn’t intend to have children; we wanted to finish our studies and find a job. Condoms were always used for contraception. And as in the joke - it tore. I had to run to the pharmacy for help. The pharmacist recommended Postinor. Thank God everything worked out! I was satisfied with the drug. I did not feel any discomfort during the appointment.

Elena, 25 years old, Moscow

I took Postinor several times. It works well, but it always disrupts the cycle for at least five days.

Zhanna, 31 years old, Kemerovo

I advise patients not to get involved in Postinor. The drug is hormonal. Without harm to the body, it can be used no more than once a year. For systemic contraception, it is better to use other methods (condoms, COCs or suppositories, ointments with benzalkonium chloride).

Anna, obstetrician-gynecologist, Saratov

And I had to use this drug. For others, I would advise not to take it on an empty stomach. I immediately started to feel sick, and then vomiting appeared. It's really effective though.

Veronica, 21 years old, Kaliningrad

You can also learn about the mechanism of action of the drug Postinor from the following video.

Instructions for medical use of the drug

Description of pharmacological action

It has pronounced progestogenic and antiestrogenic properties. Causes inhibition of ovulation and changes in the endometrium, prevents the implantation of a fertilized egg. Increases the viscosity of cervical mucus, which interferes with the advancement of sperm.

Indications for use

Emergency postcoital contraception in the following emergency situations:

1. If unprotected sexual intercourse occurred;

2. If the method of contraception used cannot be considered reliable, for example:
- breaking, slipping or improper use of a condom;
- shift, rupture or premature removal of the diaphragm or cervical plate (pessary);
- unsuccessful use of the method of interrupted sexual intercourse;
- erroneous calculation of ovulation days when using the calendar method;
- loss or removal of an intrauterine contraceptive device;
- skipping 3 or more tablets while constantly taking hormonal contraceptives;

3. Rape.

Release form

Tablets 0.75 mg; contour packaging 2 cardboard packs 1;

Pharmacodynamics

A synthetic drug with a contraceptive effect, pronounced gestagenic and antiestrogenic properties. With the recommended dosing regimen, levonorgestrel suppresses ovulation and fertilization if sexual intercourse occurs in the preovulatory phase, when the possibility of fertilization is greatest. It may also cause changes in the endometrium that prevent implantation. The drug is not effective if implantation has already occurred.

Pharmacokinetics

When taken orally, it is quickly and completely absorbed from the gastrointestinal tract. Cmax in plasma is observed after 1.6 hours and is 14.1 ng/ml. Binds to albumin and sex hormone binding globulin. Passes into breast milk: during breastfeeding, about 0.1% of levonorgestrel passes into the newborn's body along with breast milk. Levonorgestrel is metabolized in the liver, its biotransformation corresponds to the metabolism of steroids. Pharmacologically active metabolites of levonorgestrel are unknown. The concentration in the blood decreases in 2 phases, T1/2 is 2–7 hours. 60% of the drug in the form of metabolites is excreted in the urine, 40% in feces.

Use during pregnancy

Contraindicated during pregnancy.

Lactation period. Possible effects on infants can be minimized if the nursing mother takes both tablets immediately after breastfeeding and does not breastfeed after taking the drug.

Use for renal impairment

Data on the use of the drug in patients with impaired renal function are not provided.

Contraindications for use

Hypersensitivity to the components of the drug, severe liver or biliary tract diseases, genital bleeding of unknown etiology (including metrorrhagia), thrombosis of arteries and veins, thromboembolism (history), pregnancy (including suspected); relative contraindication - puberty.

Children. Prescribing Postinor tablets to children is not recommended, because There are currently few data available on the use of the drug in children under 16 years of age.

Side effects

From the endocrine system: dysmenorrhea (including bloody intermenstrual discharge), a feeling of tension in the mammary glands, delayed menstruation (for most women, the next menstruation occurs at the usual time, but if the delay in menstruation is more than 5 days, pregnancy should be excluded).

From the digestive system: nausea, vomiting, diarrhea.

Other: fatigue, dizziness.

Directions for use and doses

Orally, without chewing, with a small amount of water, regardless of meals; after sexual intercourse, within 48 hours, but no later than 72 hours, take 1 tablet. of the drug, and 12 hours after the first dose, take 1 more tablet.

If vomiting occurs within 2 hours after taking the tablet, the tablet should be repeated.

Postinor tablets can be used on any day of the menstrual cycle.

Overdose

There is no evidence of severe side effects after taking a large dose of the contraceptive. Symptoms: nausea, menstruation irregularities.

Treatment: symptomatic. There is no specific antidote.

Interactions with other drugs

When used simultaneously with inducers of liver enzymes, the metabolism of levonorgestrel is enhanced. When used together with ampicillin, rifampicin, tetracyclines, barbiturates, primidone, phenytoin, carbamazepine, ritonavir, rifabutin, griseofulvin, the contraceptive effect of Postinor may decrease. When used simultaneously with cyclosporine, the toxicity of the latter increases due to inhibition of its metabolism.

Special instructions for use

Use strictly as prescribed by your doctor to avoid complications.

Postinor is recommended for women with a regular menstrual cycle. Repeated use of Postinor during the same menstrual cycle should be avoided due to the possibility of menstrual irregularities. It is not allowed to be used as a means of regular and continuous contraception, because this leads to a decrease in the effectiveness of the drug and an increase in adverse reactions.

Postinor tablets do not replace regular contraception. If you have regular sexual activity, it is recommended to use other methods of contraception.

In case of uterine bleeding, a gynecological examination is recommended.

If pregnancy nevertheless develops against the background of Postinor, or Postinor was taken against the background of an existing pregnancy, the risk of negative effects on the fetus has not been established.

The drug does not have a negative effect on the ability to drive a car or perform work that requires a high speed of mental and physical reactions.

Storage conditions

List B.: At a temperature of 15–25 °C.

Best before date

ATX classification:

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Postinor, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Postinor is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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