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Properties of polyoxidonium. Polyoxidonium ® (Polyoxidonium ®) instructions for use

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

P N002935/04

Trade name:

Polyoxidonium ®

International nonproprietary name:

Azoximer bromide (Azoximeri bromidum)

Chemical name:

copolymer of N-oxide of 1,4-ethylenepiperazine and (N-carboxymethyl)-

1,4-ethylenepiperazinium bromide

Dosage form:

pills

Composition per tablet:

Active ingredient: Azoximer bromide – 12 mg;

Excipients: mannitol - 3.6 mg, povidone K 17 - 2.4 mg, lactose monohydrate - 185.0 mg, potato starch - 45.0 mg, stearic acid - 2.0 mg.

Description:

round, flat-cylindrical tablets of white or white with a yellowish tint, with a chamfer, with a score on one side and with the inscription “PO” on the other.

Pharmacotherapeutic group:

immunomodulatory agent.

ATX code:

Pharmacological properties

Pharmacodynamics

Azoximer bromide has a complex effect: immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory.

The basis of the mechanism of immunomodulatory action of Azoximer bromide is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation and the synthesis of interferon-alpha and interferon-gamma.

The detoxification and antioxidant properties of Azoximer bromide are largely determined by the structure and high-molecular nature of the drug.

Azoximer bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, complications after surgical operations.

A characteristic feature of Azoximer bromide when applied topically (sublingually) is the ability to activate factors of the body's early defense against infection: the drug stimulates the bactericidal properties of neutrophils, macrophages, enhances their ability to absorb bacteria, increases the bactericidal properties of saliva and secretions of the mucous membranes of the upper respiratory tract.

When administered orally, Azoximer bromide also activates lymphoid cells in the intestinal lymph nodes.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins and heavy metal salts from the body, and inhibits lipid peroxidation, both by intercepting free radicals and by eliminating catalytically active Fe 2+ ions. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Azoximer bromide is odorless and tasteless, and does not have a local irritating effect when applied to the mucous membranes of the nose and oropharynx.

Pharmacokinetics

After oral administration, azoximer bromide is rapidly absorbed from the gastrointestinal tract; the bioavailability of the drug when administered orally is more than 70%. The maximum concentration in blood plasma is achieved 3 hours after ingestion. The pharmacokinetics of Azoximer bromide is linear (plasma concentration is proportional to the dose taken).

Azoximer bromide is a hydrophilic compound. The apparent volume of distribution is approximately 0.5 l/kg, which indicates that the drug is distributed mainly in the interstitial fluid. The half-life of absorption is 35 minutes, the half-life is 18 hours.

Azoximer bromide is quickly distributed throughout all organs and tissues of the body, penetrates the blood-brain and blood-ophthalmic barriers. There is no cumulative effect. In the body of Azoximer, bromide undergoes biodegradation to low molecular weight oligomers, is excreted mainly by the kidneys, with feces - no more than 3%.

Indications for use

It is used in adults and children over 3 years of age for the treatment and prevention of acute and chronic respiratory diseases in the stage of exacerbation and remission.

For treatment (in complex therapy):

· acute and exacerbation of chronic recurrent infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper and lower respiratory tract, inner and middle ear;

· allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections;

For prevention (monotherapy):

recurrent herpetic infection of the nasal and labial region;

· exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;

· secondary immunodeficiency conditions arising due to aging or exposure to adverse factors.

Contraindications

· increased individual sensitivity;

· pregnancy, breastfeeding period;

· children under 3 years of age;

acute renal failure;

· rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

Carefully

If you have the diseases listed in this section, consult your doctor before starting to take the drug:

Chronic renal failure (used no more than 2 times a week).

Use during pregnancy and during breastfeeding

The use of the drug Polyoxidonium ® is contraindicated for pregnant women and women during breastfeeding (there is no clinical experience of use).

Experimental use of the drug Polyoxidonium ® in animals did not reveal embryotoxic or teratogenic effects or effects on fetal development.

Before using Polyoxidonium ® if you are pregnant, or think you might be pregnant, or are planning a pregnancy, you should consult your doctor.

During breastfeeding, before using the drug Polyoxidonium ®, you should consult your doctor.

Directions for use and doses

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Orally and sublingually 20-30 minutes before meals every day, 2 times a day: children over 10 years old and adults - 1 tablet, children from 3 to 10 years old - ½ tablet (6 mg).

If necessary, repeated courses of therapy are possible after 3-4 months. When the drug is re-prescribed, its effectiveness does not decrease.

Sublingually

For treatment in adults:

10 days;

· allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 10 days.

For treatment in children aged 3 to 10 years:

· influenza and acute respiratory infections – ½ tablet 2 times a day for 7 days;

· inflammatory processes of the oropharynx – ½ tablet 2 times a day for
7 days;

· allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - ½ tablet 2 times a day for 7 days.

· influenza and acute respiratory infections – 1 tablet 2 times a day for 7 days;

· inflammatory processes of the oropharynx – 1 tablet 2 times a day for
7 days;

· exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis media - 1 tablet 2 times a day for
7 days;

· allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 7 days.

For prevention in adults:

By
1 tablet per day for 10 days;

1 tablet 2 times a day for 10 days;

· exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1 tablet once a day for 10 days;

· secondary immunodeficiencies arising due to aging or exposure to adverse factors - 1 tablet 1 time per day for 10 days.

For prevention in children aged 3 to 10 years:

· influenza and acute respiratory infections in the pre-epidemic period –
½ tablet per day for 7 days;

· recurrent herpetic infection of the nasal and labial area –
½ tablet 2 times a day for 7 days;

· exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - ½ tablet once a day for 10 days.

For prevention in children over 10 years of age:

· influenza and acute respiratory infections in the pre-epidemic period –
1 tablet per day for 7 days;

· recurrent herpetic infection of the nasal and labial area –
1 tablet 2 times a day for 7 days;

· exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear, 1 tablet once a day for 10 days.

oral

For treatment in adults:

For treatment in children over 10 years of age:

diseases of the upper and lower respiratory tract - 1 tablet 2 times 10 days.

Side effect

No side effects have been reported.

If you notice any side effects not listed in the instructions, tell your doctor.

Overdose

No cases of overdose have been registered.

Interaction with other drugs

Azoximer bromide does not inhibit the isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, cytochrome P-450, therefore the drug is compatible with antibiotics, antiviral, antifungal and antihistamines, glucocorticosteroids and cytostatics.

If you are taking the above or other medications (including over-the-counter medications), consult your doctor before taking Polyoxidonium.

special instructions

If an allergic reaction develops, you should stop using the drug Polyoxidonium ® and consult a doctor.

If it is necessary to stop taking the drug Polyoxidonium ®, cancellation can be done immediately, without gradually reducing the dose.

If you miss the next dose of the drug, its subsequent use should be carried out as usual, as indicated in these instructions or recommended by your doctor. The patient should not administer a double dose to compensate for missed doses.

Do not use the drug if there are visual signs of its unsuitability (defective packaging, discoloration of the tablet).

Impact on the ability to drive vehicles and other mechanisms

In this medical article you can familiarize yourself with the drug Polyoxidonium. The instructions for use will explain in what cases you can take suppositories, injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Polyoxidonium, from which one can find out whether the medicine has helped in the treatment of immunodeficiencies and related infectious diseases in adults and children, for which it is also prescribed. The instructions list analogues of Polyoxidonium, prices of the drug in pharmacies, as well as its use during pregnancy.

An immunostimulating agent that increases the body's resistance to local and generalized infections is Polyoxidonium. Instructions for use prescribe the use of 12 mg tablets, 6 mg and 12 mg suppositories, injections in 3 mg and 6 mg injection ampoules to increase the body's resistance to infectious pathologies.

Release form and composition

The following dosage forms of Polyoxidonium are produced:

Tablets 12 mg.
Suppositories for vaginal or rectal use 6 mg and 12 mg.
Lyophilisate for the preparation of a solution for injection and local use (injections in ampoules) 3 mg and 6 mg.

Active ingredient – azoximer bromide (polyoxidonium):

bottle of lyophilisate – 3 mg or 6 mg;
tablet – 12 mg;
suppository – 6 mg or 12 mg.

pharmachologic effect

The drug Polyoxidonium helps restore the immune status in secondary immunodeficiency conditions, which are caused by various types of infections, injuries, burns, malignant tumors, complications after surgical interventions, treatment with chemotherapy drugs, including cytostatic agents and steroid hormones.

Along with the immunocorrective effect of azoximer, bromide also has a pronounced detoxifying effect, which is due to the structure and high-molecular nature of this substance.

The result of its effect on the body is an increase in the resistance of cell membranes to the cytotoxic (causing damage to cells up to their death) action of drugs and chemicals, as well as a decrease in the toxicity of the latter.

Prescribing Polyoxidonium in combination with other drugs significantly increases the effectiveness of therapy, shortens its duration, allows you to reduce doses or completely avoid the use of antibiotics, bronchodilators and glucocorticosteroids, and helps to increase the period of remission (that is, the period of weakening or complete disappearance of the symptoms of the disease).

The medication is well tolerated by patients, does not exhibit mitogenic or polyclonal activity, does not have antigenic properties, does not provoke the development of allergies, mutations and other defects in fetal development, does not have a teratogenic effect on the developing fetus, and does not have carcinogenic or embryotoxic properties.

Why is Polyoxidonium prescribed?

Indications for use of the drug include correction of immunity in adults and children from 6 months of age.

What does it help children with? In complex therapy, pediatricians prescribe the drug:

intestinal dysbiosis (in combination with specific therapy);
atopic dermatitis complicated by purulent infection;
prevention of influenza and acute respiratory infections;
acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI);
for the rehabilitation of those who are often and long-term ill;
acute allergic and toxic-allergic conditions;
bronchial asthma complicated by chronic respiratory tract infections.

In adults in complex therapy:

acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
with rheumatoid arthritis complicated by acute respiratory infections;
to activate regenerative processes (fractures, burns, trophic ulcers);
for the prevention of influenza and acute respiratory infections;
for the prevention of postoperative infectious complications;
chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the acute stage and in remission;
tuberculosis;
in oncology during and after chemotherapy and radiation therapy to reduce the immunosuppressive, nephro- and hepatotoxic effects of drugs;
acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infections;
rheumatoid arthritis.

Contraindications

The use of Polyoxidonium is contraindicated in patients with hypersensitivity to the components of the drug. Azoximer bromide should be used with caution when treating patients with acute renal failure. Lyophilisate and suppositories should not be prescribed during pregnancy and breastfeeding.

Lyophilisate: up to 6 months - with caution.
Tablets: up to 12 years.
Candles: for children under 6 years old.

Instructions for use

Pills

Polyoxidonium instructions for use prescribe taking it orally or sublingually. It is recommended to take half an hour before meals twice a day. Children over 10 years of age and adult patients are prescribed one tablet. Children 3-10 years old are prescribed ½ tablet. If necessary and according to the doctor’s instructions, the course of treatment can be repeated after 3-4 months.

Sublingual tablets

Dosage for the treatment of adult patients and children over 10 years of age:

Exacerbation of chronic diseases of the upper respiratory system and otitis is prescribed 1 tablet twice a day for 10 days, for patients 10-18 years old - the duration of therapy is 7 days.
For the treatment of allergic diseases complicated by fungal, viral or bacterial infections, the recommended dose is 1 table. twice a day for 10 days, and for children 10-18 years old - for a week.
Flu and ARVI - 1 tablet twice a day for a week.
Inflammatory lesions of the oropharynx - 1 tablet. twice a day for 10 days, for children 10-18 years old for 7 days.
For the treatment of the above diseases in children, ½ tablet is used. twice a day for a week.

Disease prevention:

Secondary immunodeficiencies: adults – 1 tablet per day for 10 days.
ARVI and influenza: adults – 1 tablet. per day for 10 days; children 3-10 years old – ½ tab. per day for a week.
Herpes of the nasal and labial area: adults – 1 tablet. twice a day for 10 days; children 3-10 years old – ½ table. twice a day for 7 days.
Exacerbation of chronic infectious diseases of the ear, oropharynx and upper respiratory organs: adults: 1 table. per day for 10 days; children 3-10 years old – ½ tablet, course of treatment – 10 days.

Oral administration of tablets

The drug is taken to treat children over 10 years of age and adult patients. The recommended dosage is 1 tablet twice a day for 10 days.

Suppositories Polyoxidonium

Suppositories 12 mg and 6 mg are administered rectally, after the bowel cleansing procedure, once a day (before bedtime). A single dose is one suppository. The scheme of their administration is as follows: daily, one at a time in the first 3 days, then - also one at a time - after 2 days. A full course requires 10 suppositories.

Intravaginal use is indicated for the treatment of gynecological diseases: dysplasia, erosion, cervical lekoplakia, colpitis, adnexitis, endometritis, as well as diseases provoked by human papillomavirus (HPV).

Treatment involves daily administration of one suppository for three days with a dosage of the active substance of 12 mg, after which the suppositories continue to be administered every other day. The course is carried out using 10 suppositories. In cases where it is appropriate, the course of treatment can be repeated after 3-4 months.

For patients diagnosed with chronic immune deficiency (including patients in whom such a condition was the result of cancer), Polyoxidonium is prescribed as a maintenance agent in a dose of 6 or 12 mg (according to the doctor’s indications) 1-2 times a week. The treatment is long-term.

Lyophilisate

Injections in ampoules are intended for parenteral (intramuscular (IM) or intravenous (IV)), intranasal and sublingual administration in children. Rules for preparing the solution:

IM administration: for adults – dissolve the contents of 1 bottle (6 mg) in 1.5-2 ml of water for injection or 0.9% sodium chloride solution; for children – dissolve 3 mg of the drug in 1 ml of 0.9% sodium chloride solution or water for injection;

IV drip administration: for adults - the contents of 1 bottle (6 mg) are dissolved in 2 ml of a 5% dextrose solution, 0.9% sodium chloride solution, hemodez-N or rheopolyglucin, then mixed with the selected solution in a volume of 200-400 ml; for children - dissolve 3 mg in 1.5-2 ml of 0.9% sodium chloride solution, hemodez-N, rheopolyglucin or 5% dextrose solution, then transfer the resulting solution into a bottle with 150-250 ml of the selected solution;

Intranasal administration: for adults – the contents of 1 bottle (6 mg), for children – ½ bottle (3 mg), should be dissolved in 1 ml of 0.9% sodium chloride solution, distilled or boiled water at room temperature.

One drop of the resulting solution for intranasal administration in children contains 0.15 mg of azoximer bromide. This solution is also used for sublingual use; it can be stored for no more than 7 days in the refrigerator; before use, the pipette is warmed to room temperature.

A solution for parenteral administration should be prepared before direct use. The route of administration and dose is determined by the doctor based on clinical indications, taking into account the patient’s age. Recommended dosage for parenteral administration:

Tuberculosis: 6-12 mg 2 times a week, course of treatment – 10-20 injections;
Correction of immunodeficiency after surgical removal of a tumor, radiation and chemotherapy, prevention of immunosuppressive effects: 6-12 mg 1-2 times a week for a long period. In case of acute renal failure, the drug should be administered no more than 2 times a week.
Acute inflammatory pathologies: adults – 6 mg per day for 3 days, then – once every 2 days, a total of 5-10 injections; children – at the rate of 0.1 mg per 1 kg of child’s weight per day, the procedure is carried out every other day, a total of 5-7 injections;
Rheumatoid arthritis: 6 mg every other day - 5 injections, then 2 times a week, for a total of at least 10 injections;
Acute and chronic urogenital pathologies: 6 mg every other day, a total of 10 injections in combination with chemotherapy; Chronic recurrent herpes: 6 mg every other day, course of therapy - 10 injections with simultaneous administration of antiviral agents, interferons and inducers of interferon synthesis;
Chemotherapy for oncological pathologies: 6-12 mg every other day, course - at least 10 injections, then the frequency of administration is prescribed individually, taking into account the tolerability and duration of radiation and chemotherapy;
Complicated forms of allergic diseases: adults – 6 mg 1 time per day for 2 days, then every other day, a total of 5 injections; children - 0.1 mg intramuscularly per 1 kg of body weight per day after 1-2 days, a total of 5 injections in combination with basic therapy;
Inflammatory diseases of chronic origin: adults – 6 mg 1 time per day every other day (5 injections), then – 2 times a week, course of treatment – at least 10 injections; children - 0.15 mg per 1 kg of weight every 3 days, course of treatment - up to 10 injections;
Acute allergic and toxic-allergic conditions (iv in combination with antiallergic drugs): adults - 6-12 mg, children - 0.15 mg per 1 kg of weight;

Recommended dosage for intranasal administration:

Adults: 3 drops in each nasal passage 3 times a day for 5-10 days;
Children: 1-3 drops in one nasal passage 2-4 times a day.

Sublingual administration of the solution to children (for all indications): 0.15 mg per 1 kg of body weight per day for 10 days, and for intestinal dysbiosis - 10-20 days.

Side effects

The use of lyophilisate may cause pain at the injection site.

Children, pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and breastfeeding. Experimental studies on animals have not revealed a negative effect of Polyoxidonium on the fertility of females and males.

Also, no teratogenic or embryotoxic effects of the drug or its effect on fetal development were detected throughout pregnancy and during lactation.

special instructions

For suppositories and tablets.

The patient should be aware that the duration of the course of therapy and the indicated doses should not be exceeded without prior consultation with the attending physician.

For lyophilisate for the preparation of injection solution.

If there is pain at the injection site during intramuscular administration, Polyoxidonium is dissolved in 1 ml of 0.25% procaine solution (provided the patient does not have hypersensitivity to procaine). For intravenous (drip) administration, the lyophilisate is not recommended to be dissolved in protein-containing infusion solutions.

All dosage forms are compatible with antiviral, antibiotics, antihistamines and antifungals, corticosteroids, bronchodilators, and cytostatics. The drug does not affect the ability to control complex mechanisms and drive a car.

Drug interactions

Polyoxidonium can be used in combination with antibiotics, antiviral and antihistamines, antimycotics, cytostatic, glucocorticosteroid and bronchodilator drugs, β-adrenergic stimulants.

If it is necessary to administer the solution by drop method into a vein, it should not be diluted with infusion solutions that contain proteins.

Analogues of the drug Polyoxidonium

Analogues of the drug by mechanism of action:

Broncho-Vaxom.
Affinoleukin.
Arpeflu.
Neuroferon.
Actinolysate.
Florexil.
Glutaxim.
Vilozen.
Anaferon.
Ribomunyl.
Engystol.
Immunofan.
Immunal.
Ismigen.
Cycloferon.
Taktivin.
Gerbion.
Cytovir-3.
Gepon.
Bioaron.
Polymuramyl.
Bestin.
Isophon.
Arpetolid.

Vacation conditions and price

The average price of Polyoxidonium (12 mg tablets No. 10) in Moscow is 570 – 765 rubles. Vaginal and rectal suppositories 6 mg (10 pieces per package) can be purchased for 795–910 rubles, injections — 665–755 rubles. In Kyiv you can buy medicine for 16 hryvnia, in Kazakhstan - for 245 tenge.

In Minsk, pharmacies offer the drug for 2 bel. ruble. Sold according to prescription. Tablets and suppositories are classified as over-the-counter drugs; a prescription is required to purchase the lyophilisate.

The drug is contraindicated for persons with individual intolerance to its components.

Side effects

Side effects of using tablets and suppositories are hypersensitivity reactions. When the drug is administered intramuscularly, some patients may experience redness and soreness at the injection site. After the first injections of Polyoxidonium, body temperature may increase.

Instructions for Polyoxidonium (Method and dosage)

The dose and route of administration will be determined depending on the diagnosis, the characteristics of the course of the disease and the age of the patient.

Instructions for Polyoxidonium tablets

The tablets are intended for sublingual (under the tongue) or oral (by mouth) administration. They are drunk daily, one, two or three times a day (the frequency of doses depends on the nature of the disease and the severity of the clinical picture) 20-30 minutes before meals.

A single dose of the drug for adults is 1 tablet (equivalent to 12 mg azoximer bromide ), children from 3 to 10 years old are prescribed to take 0.5 tablets per dose.

Instructions for use of Polyoxidonium in the form of lyophilisate

The solution is administered intramuscularly or by drip into a vein, applied intranasally.

For treatment acute inflammatory diseases the drug is administered daily for 3 days at a dose of 6 mg. Further, Polyoxidonium injections continue to be given every other day. Typically, the patient requires five to ten injections.

For treatment chronic inflammatory diseases And rheumatoid arthritis The first 5 injections are given every other day, then the drug is continued to be administered 2 times a week. A single dose of the active substance is 6 mg. The full course involves at least ten injections.

Patients who have been diagnosed are prescribed 6 mg of the drug 2 times a week. The full course is from ten to twenty injections.

Patients with diseases of the urogenital tract Ten injections are recommended (every other day). Single dose - 6 mg. Therapy is supplemented with prescription chemotherapy drugs .

Patients with chronic recurrent . In this case, Polyoxidonium is prescribed in combination with stimulators of endogenous interferon synthesis, antiviral agents, drugs interferon .

Therapy for complicated cases allergic diseases involves administering five single doses of the drug (6 mg) to the patient. The first two injections are recommended to be given daily, the remaining three injections are given every other day.

For patients undergoing the course chemotherapy (and also after its completion) to reduce the specific effect of chemotherapeutic agents, the drug is prescribed in a dose of 6-12 mg. It is considered optimal to carry out at least ten injections (maintaining a daily interval between them).

For correction of immunodeficiency after radiation and chemotherapy, after surgical removal of the tumor The patient is given a dose of 6 mg 1-2 times a week. The course of treatment is quite long - usually from 2-3 to 12 months.

According to the instructions for use, Polyoxidonium injections for patients with acute The drug may be administered no more than 2 times a week.

To prepare a solution for intramuscular injection, 6 mg of the active substance (the contents of one ampoule or bottle) is combined with 1.5-2 ml of NaCl solution or water for injection.

A solution for drip administration into a vein is prepared by mixing the contents of one ampoule or bottle with 3 ml of NaCl solution, plasma replacement drug or 5% glucose solution. The resulting solution must be transferred under sterile conditions into a bottle with any of the above solutions with a volume of 0.2-0.4 liters.

The solution for parenteral administration must be used immediately after preparation; it cannot be stored.

Intranasal use is indicated for acute and chronic infectious ENT diseases, to accelerate the regeneration of mucous membranes, to prevent the development of complications and relapses of diseases, to prevent influenza and respiratory diseases.

To prepare a nasal solution, 6 mg of lyophilisate is combined with one milliliter (20 drops) of distilled water, NaCl solution or ordinary boiled water. In this case, the temperature of the liquid should be room temperature.

The solution is injected into each nasal passage at least 3-4 times during the day, leaving 2-3 hours between instillations. Single dose: 1 to 3 drops in each nostril. Treatment is continued for five to ten days.

After dilution, the drug remains stable for 24 hours, after which it cannot be used.

Polyoxidonium suppositories, instructions for use

Suppositories 12 mg and 6 mg are administered rectally, after the bowel cleansing procedure, once a day (before bedtime). Single dose - one suppository. The scheme of their administration is as follows: one daily for the first 3 days, then one at a time after 2 days. A full course requires 10 suppositories.

Intravaginal use is indicated for the treatment of gynecological diseases: dysplasia , lekoplakia of the cervix , colpitis , adnexitis , endometritis , as well as diseases provoked human papillomavirus (HPV).

Patients diagnosed with chronic immune deficiency (including patients in whom such a condition resulted from cancer ) Polyoxidonium is prescribed as a maintenance agent in a dose of 6 or 12 mg (according to the doctor’s indications) 1-2 times a week. The treatment is long-term.

Overdose

There is no data on an overdose of Polyoxidonium in the form of tablets and suppositories. When using the solution in prescribed therapeutic doses, cases of overdose were also not recorded. Potentially increased side effects.

If signs of overdose appear, symptomatic therapy is recommended.

Interaction

It is allowed to use Polyoxidonium in combination with antiviral and antihistamines, antimycotics , cytostatic, glucocorticosteroid and bronchodilator drugs, β-agonists .

If it is necessary to administer the solution by drop method into a vein, it should not be diluted with infusion solutions that contain proteins.

Terms of sale

Tablets and suppositories are classified as over-the-counter drugs; a prescription is required to purchase the lyophilisate.

Storage conditions

Pills stored at a temperature not exceeding 25°C. Keep away from children

Suppositories included in List B. It is recommended to store them in a dry, dark place. Keep away from children. The optimum temperature regime is from 2° to 15°С.

Lyophilisate should be stored in a dry, dark place. The optimum temperature regime is from 4 to 8 ° С. Keep away from children.

Best before date

Analogues of Polyoxidonium

Level 4 ATX code matches:

Analogues of the drug according to the mechanism of action: Actinolysate , Arpetolide , Affinoleukin , Bestin , Bioaron , Wilosen , , Gerbion , Glutaxim , Isophone , Immunofan , Neuroferon , Florexil , Polymuramyl , Ismigen .

Polyoxidonium for children

In pediatric practice, the use of tablets is allowed from the age of 3, suppositories are used from the age of six, and lyophilisate is used from six months.

Polyoxidonium is prescribed for children as an addition to the main therapy. Indications for use are acute and chronic infectious and inflammatory diseases (including ARVI And ENT diseases ), allergy And toxic-allergic conditions complicated by chronic infectious processes in the respiratory tract, occurring with complications (including complicated by purulent infection) atopic dermatitis, dysbacteriosis .

For children included in the "CHBD" group, the drug is used to speed up the process of their rehabilitation. In addition, Polyoxidonium has a preventive effect against flu And colds .

Tablets are taken sublingually or orally at a dose of 6 mg (half a tablet), daily, with a frequency of applications 1, 2 or 3 times a day.

The optimal dose, number and frequency of injections are determined depending on the diagnosis and age of the child:

For acute inflammatory diseases carrying out in a day from five to seven injections is shown. Dose: 100 mcg/kg. If the disease is chronic, the dose is increased to 150 mcg / kg. The introduction of the drug is carried out every other day. The course involves the administration of up to ten single doses.
For treatment allergies And toxic-allergic conditions drip administration of the drug into a vein at a dose of 150 mcg/kg is indicated. Therapy is supplemented with the appointment of other drugs that have an antiallergic effect. If the disease proceeds with complications, injections are prescribed as an addition to basic therapy. The patient is shown 5 intramuscular injections at a dose of 100 mcg/kg. The interval between administrations is 1-2 days.

A solution for intramuscular injection is prepared by dissolving 3 mg of the drug in 1 ml of NaCl solution (you can use water for injection).

A solution for intravenous administration is prepared by diluting 3 mg of the drug in 1.5-2 ml of NaCl solution, 5% glucose solution, or , after which, under sterile conditions, add it to a bottle with one of the indicated solutions with a volume of 0.15-0.25 l.

Intranasal Polyoxidonium is used daily for five to ten days, instilling it at least 3-4 times a day into each nostril in a dose of 1 to 3 drops. The daily dose is 150 mcg/kg of body weight. The interval between procedures is 2-3 hours.

To prepare a solution for topical use, add 1 ml (equivalent to 20 drops) of liquid at room temperature (0.9% NaCl solution, distilled or ordinary boiled water) to 3 mg of the drug.

For children, the solution is prescribed at a dose of 150 mcg of the active substance per kilogram of body weight (this amount is contained in one drop of the solution).

Sublingual drug is prescribed to be taken daily for 10 days. The daily dose for all indications is 150 mcg / kg. If the drug is used to treat dysbiosis, the course usually lasts from 10 to 20 days.

The solution is stored in the refrigerator for no more than one week. Before instilling the drug, the pipette with the solution must be warmed to room temperature.

According to the instructions for suppositories for children, the drug in this dosage form can be used rectally to treat patients over 6 years of age. According to the doctor’s indications, suppositories are administered one at a time daily or every other day before bedtime.

Polyoxidonium suppositories for children - reviews confirm this - are an effective remedy, however, the desired effect from their use can only be achieved in cases where the treatment regimen is selected by an experienced doctor and takes into account the characteristics of the disease and the body of a particular child.

Application for pregnant and lactating women

There is no data on the safety of using Polyoxidonium in pregnant and lactating women, and therefore the drug is not prescribed to these categories of patients.

Reviews for Polyoxidonium

Reviews about the drug are mostly positive. This is due to the fact that it effectively treats chronic and complicated diseases that cannot be treated with standard therapy.

Reviews of Polyoxidonium suppositories, tablets and solution are evidence of the effectiveness of each of these dosage forms. Against the background of the use of the drug in complex therapy, the patient recovers faster, and the disease proceeds in a much milder form.

Using the drug as a prophylactic for children can reduce the incidence of diseases. Reviews of doctors on Polyoxidonium allow us to conclude that this remedy is really indispensable.

Prescribing suppositories, tablets or nasal solution to children promotes faster adaptation to being in a group (at school or kindergarten). At the same time, children are much less susceptible to infections even during periods of seasonal epidemics.

Most of the positive reviews of Polyoxidonium in suppositories and other dosage forms are due to the fact that the drug is easy to use, well tolerated by children and practically does not cause side effects.

For adults, Polyoxidonium is most often prescribed for the treatment of infectious diseases. The use of suppositories in gynecology in combination with the main therapy not only helps to effectively eliminate the symptoms of the disease, but also significantly increases and, accordingly, helps prevent relapses and complications.

Having analyzed reviews of Polyoxidonium injections, we can say with confidence that the drug has a positive effect even in quite complex cases when the patient’s body is weakened cancer and its treatment.

Rare negative reviews are due to the fact that the drug did not produce visible changes in the patient’s condition, which in some cases may be the result of an incorrectly selected dosage regimen that does not take into account the individual characteristics of the patient’s body.

Reviews note the high cost of Polyoxidonium, however, given that the drug is effective, helps quickly and for a long time, eases the course and reduces the incidence of diseases, does not cause pain when administered (this applies to all dosage forms with the exception of injections, the latter, on the contrary, are very painful) , this "flaw" for most patients fades into the background.

Polyoxidonium price, where to buy

The average price of Polyoxidonium tablets is 540 UAH. The price of Polyoxidonium 12 mg candles is 750 UAH, you can buy 6 mg candles for an average of 580 UAH. Price of Polyoxidonium in ampoules (6 mg injections) - from 600 to 1200 UAH.

You can buy 12 mg tablets in Moscow for an average of 660-750 rubles. The price of 6 mg ampoules is from 950 rubles. 6 mg suppositories cost approximately 750 rubles, 12 mg suppositories cost 850 rubles.

Online pharmacies in Russia Russia
Online pharmacies in Kazakhstan Kazakhstan

ZdravCity

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Polyoxidonium liof. for prig. injection solution and local approx. 6mg vial. No. 5Petrovax Pharm NPO LLC

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Polyoxidonium lyophilisate for injection 3 mg n5Petrovax Pharm NPO, LLC

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Polyoxidonium lyophilisate for injection 6 mg n5Petrovax Pharm NPO, LLC

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Petrovax Pharm NMC LLC, Russia

BIOSPHERE

Polyoxidonium 3 mg No. 5 por.liof.d/in. bottle
Polyoxidonium 12 mg No. 10 supp.Petrovax Pharm LLC NPO (Russia)
Polyoxidonium 6 mg No. 10 supp.Petrovax Pharm LLC NPO (Russia)
Polyoxidonium 6 mg No. 5 por.liof.d/in. bottlePetrovax Pharm LLC NPO (Russia)
Polyoxidonium 12 mg No. 10 tab.Petrovax Pharm LLC NPO (Russia)
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Author-compiler:- pharmacist, medical journalist Speciality: Pharmacist

Education: She graduated from the Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.

Experience: From 2003 to 2013 she worked as a pharmacist and head of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.

NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Polyoxidonium, be sure to consult with your doctor.

Maruseva | 17:04 | 06.06.2019

Camilla | 17:04 | 06.06.2019

The pediatrician prescribed polyoxidonium suppositories for us, I heard about them for the first time, but to be honest, we have never seen a better medicine before. My daughter is 7 years old and fell ill with a common ARVI, but she complained that these colds were becoming more frequent. This is probably why they were prescribed to us, because I later read in the instructions that it strengthens the immune system well. Indeed, after them we were not sick at all for 2 months. But I would also like to say that polyoxidonium in suppositories helps treat the cold itself very well and quickly, it really removes the symptoms, prevents you from getting very sick, you feel better the very next day and everything generally goes away easier and faster.

Polezhaikina A. | 17:50 | 08.05.2019

Polyoxidonium suppositories are very effective for viral diseases. I just use them to raise both children to their feet. Although they have become much less likely to get sick with me, they still caught the flu in a new wave of the epidemic, it’s just that their whole school is sick, I can imagine what a hotbed of infection there. We have already taken polyoxidonium before, and it has proven to be an effective drug. With it, my children cope with colds more easily and recover faster. Previously, sometimes there were even complications, but now they even hurt less. Thank you for such effective drugs.

Boucher T | 17:13 | 09.04.2019

At the insistence of a doctor friend, I recently bought polyoxidonium tablets for complex treatment. She became acutely ill with a temperature of 39.6 and did not break down at all. This is a new epidemic of a dangerous influenza virus, against which even vaccinations did not work. It is manifested by severe intoxication, and apart from polyoxidonium, no antiviral drugs remove toxins. It really helped me get over the flu easier and faster. The temperature returned to normal in two days, headaches and malaise also disappeared. In general, I recovered in probably 4-5 days. Thanks to polyoxidonium.

Svetlana | 19:27 | 14.03.2019

I’ve been treating my family with polyoxidonium for a long time, we take tablets, my daughter gets suppositories. After we started taking polyoxidonium, we don’t get sick so often, but my husband and I caught a new wave of the epidemic, it’s just that the virus is already very strong. And my daughter did well, she held out. Polyoxidonium helps to significantly reduce symptoms, make it easier and faster to get over a cold, and without side effects, I recommend it to everyone.

Olesya | 10:09 | 03.03.2019

If you don’t have time to be sick, I recommend polyoxidonium to everyone. The therapist suggested it to me. I caught the wave of the epidemic, when everyone was sick, there were pains in the eyes, a splitting headache, a sore throat - the whole bouquet. And polyoxidonium dealt with this bouquet very quickly and effectively. Within 2 days I was back to normal and recovered faster. But of course, I drank the course to the end

Inga Leonova | 13:44 | 30.01.2019

I bought polyoxidonium as prescribed by a doctor. A long cold was complicated by a purulent sore throat. In general, I felt normal, but the temperature did not go away, and a sore throat appeared when swallowing. The lozenges helped very quickly, and the next day the fever subsided. I used 2 packages for the full course (10 days, 2 tablets 2 times a day). It works effectively and quickly, I recommend it.

Zavyalova | 11:59 | 11.01.2019

Adaptation to kindergarten did not pass us by, although we tried to harden the child and gave him fresh fruits and berries from his grandmother in the village. Everything is according to the book: snot, fever, all lethargic, capricious, sometimes wants to sleep, sometimes doesn’t want to. And I’m already tired of taking days off at my own expense. We went to a private doctor. She looked at her son and said that everything was standard, but you should take Polyoxidonium, it is often prescribed for children. She said that the child will adapt faster and generally recover faster this time. We took one tablet a day, divided in half. So ten days. On the sixth day we went to kindergarten, but didn’t stop drinking. We've been going for six months now and haven't gotten sick once. Some kind of magic.

Fedyunin | 12:29 | 26.12.2018

In my time I have already tried many different antiviral agents. Most of them are difficult to describe without swearing. The rest are leaving on antihistamines, ascorbic acid and paracetamol. It's like being renovated. Some seal the cracked glass with tape to prevent it from blowing, while others replace the windows. So these funds represent the first option. It gets easier, but the problem remains. And Polyoxidonium in tablets helps eliminate the cause of the disease. My wife bought it for me when I had the flu. So he got me back on my feet at the very beginning of the course of treatment, within 1-2 days. Apparently this drug worked well on the immune system. Now it's like clockwork. Not a single virus has been leaking for a long time.

Maria | 10:49 | 07.12.2018

For us, ARVI has always been difficult. We took cough drops, nasal drips, took inhalations, kept bed rest and drinking water, but we still always had to deal with complications in the end. Most often, a sore throat appeared. And this means severe pain when swallowing, swollen tonsils and fever. Polyoxidonium helped us change the situation. The pediatrician decided that the child’s natural defenses needed help and prescribed this immunomodulator. Previously, treatment could last 2-3 weeks, but with it, a maximum of 4-5 days. It turns out that the child recovers several times faster and then hardly gets sick anymore, because... The immune system is strengthened thanks to Polyoxidonium. As a mother, I am completely satisfied with the result.

Galina Ermoshina | 12:30 | 06.12.2018

The doctor prescribed a well-known antiviral drug for ARVI to my daughter. We drank the entire course, but in the end we still had to switch to an antibiotic. And this year, as soon as the first signs of illness appeared, I gave her Polycosidonium tablets. It's a completely different matter! My daughter didn’t get sick at all, she had a slight runny nose and fever, but everything went away in a few days. I confirm that the drug is good, and the price does not scare me, since the effect is 100%.

Olga | 16:05 | 02.12.2018

Vitamins, sports, hardening procedures and fruits and vegetables are all good, but sometimes the immune system needs real help. Especially after childbirth, antibiotics, or if you are overloaded at work for a long time. For example, the immunologist prescribed me Polyoxidonium to increase my resistance to infections. I completed a ten-day course 7 months ago. So far the “flight is normal”) There has never been any flu or ARVI))

Lyudmila Kazachenko | 14:38 | 02.08.2018

Now is the best time to prepare your child for kindergarten. I did this last summer: I gave my son Polyoxidonium to drink 1.5 months before I took him to kindergarten and it helped! We lasted 7 months before the winter flu. Now this is my working scheme.

Alina | 12:22 | 25.07.2018

It quickly puts you on your feet, there is an evidence base, otherwise nowadays other antiviral drugs have problems with this. I have been buying polyoxidonium as a medicine for ARVI and influenza for 2 years now. It is important to me that appropriate research has been conducted on this drug. In addition, the child does not develop allergies from it, apparently due to the fact that it contains no substances of plant or animal origin

Olga | 12:15 | 16.07.2018

It’s a good product, I always make sure I have a couple of packs at home. In winter it saves me from influenza and ARVI, and in summer it helps if I start to acclimatize from flying to hot countries during vacation or if herpes breaks out. Usually this manifests itself in me as fever and fever for several days, and sometimes a runny nose, and herpes - where would I be without it!). Polyoxidonium helps me deal with this quickly and rest peacefully, especially since I often only have a week’s vacation.

Sintia | 15:35 | 05.07.2018

Polyoxidonium is sold in pharmacies without a prescription, i.e. when 1 pack runs out and in order to buy a new one, you don’t have to wait in line at the doctor again and so on. In addition, this is our domestic drug and can be bought without problems at any pharmacy. One cannot help but rejoice in the fact that the drug is proven and effective; this is the main thing now. You can buy it in tablets, suppositories or lyophilisate. I prefer pills because I can't miss work meetings. And he put the pills under his tongue and forgot. The price for me is adequate, after all, you save on buying a lot of unnecessary things...

Louise | 9:51 | 15.06.2018

I always take polyoxidonium with me to the sea. Because of climate change, I often develop general malaise and a slight fever. Those who have experienced this will understand me. If I start taking polyoskidonium two days before leaving for the sea, then everything will be OK. Well, if there is still a temperature, then a day, maximum two. The whole point is that polyoxidonium activates the immune system, and acclimatization often occurs in people with reduced immunity.

Lisa | 13:44 | 12.06.2018

I tried different antivirals, but this year and last year I bought polyoxidonium. And I’ll probably continue to buy) I’m not allergic to it. I don’t know what they add to our medicines now, but this is already a pattern for me; allergies occur very often. But there’s no mention of polyoxidonium, I read it, it’s because it doesn’t contain any plant substances, so it turns out :) Well, it’s not normal to choose a medicine based on allergenicity, I think, and this particular medicine also helps a lot, so I advise

Agnia | 13:05 | 11.05.2018

I took it last winter when I got the flu. Of course, I had to stay at home for 10 days, but I noticed that with polyoscidonium the pain was somehow easier. Not like last year, when I lay in bed for almost 2.5 weeks with a high fever and could barely lift my head. With these tablets, after just four days, the temperature dropped from 39 to 37.5. I didn’t have a headache, I only had body aches for the first two days. After everything, I didn’t get sick for a long time, I didn’t encounter the flu this year))) I think this is all thanks to polyoxidonium.

Tasha | 14:53 | 06.05.2018

Polyoxidonium was prescribed to my daughter during acute respiratory illness. We didn’t have any problems, it’s in tablets and needs to be dissolved. My daughter is 5 years old and she calmly took the tablet and dissolved it) The tablets are not bitter and this is a big plus, I now know how we will be treated if we get sick again. But for the last 4 months nothing has been caught, not even the March virus

Ulyana | 14:48 | 26.04.2018

Obviously not a pill for all diseases, but one of the best in its segment. The whole family was sick often and for a long time, after a course of pills (I can’t help but notice how convenient it is to give a child a pill under the tongue), the immune system began to work much better. If you have an acute respiratory viral infection, and this happens infrequently, then 4-5 days and that’s it, on business.

Grisha | 21:49 | 08.04.2018

I am an adult, and until last year I didn’t really know how to get treatment. Well, I understand there is raspberry tea, but everything always comes with complications, these runny noses after any cold. I’m tired of it. I went to the doctor like a normal person, and finally began to receive adequate treatment. They prescribed polyoxidonium tablets, and I immediately started taking them. It seems to me that everything went so easily... Like never before. On the 4th-5th day I was generally healthy, I was in culture shock. And now I have been living without illness for almost a year. Honestly, guys, I didn’t expect such an effect) Probably this medicine just suits me 100%

Siniza | 11:24 | 31.03.2018

I have polyoxidonium - this is the medicine that you carry with you so as not to get extremely sick. I am a great boss, any absence from work is idleness, so I try to take sick leave in very rare cases. Thanks to the pills, I rarely get sick, and if I do, it lasts for a couple of days and I’m back on track. At this time I go to work, I noticed that my performance remains the same, my head is fresh. And by the way, I don’t feel sleepy like I did from those antiviral medications I took before!

Lesya | 17:19 | 10.03.2018

That winter I was treating my beloved schoolboy) He came home all blue, had a lot of snot, was sneezing like crazy... I don’t remember him being so sick at all ((I got nervous and also vomited. In short, I put my feet up, called a doctor, she said - a virus, we are treating with polyoxidonium. I had never heard of it before, although how did I manage it) They prescribed it to us in tablets, although I know that it is also available in suppositories and in an injection solution. I would also like to say that polyoxidonium is suitable even for allergy sufferers (this I’m speaking from our experience, because my son is often allergic to medications, but he wasn’t allergic to this drug), so that’s also a plus. In general, on the 2nd day, my miracle even began to play the console, I touch my forehead - it’s warm, but although would not burn. It’s good that it works quickly, otherwise sometimes, as you read, children get sick for weeks, I really didn’t want that. So, after another 5 days, the cucumber and cucumber jumped to school. Such an experience, after this virus there was no I was sick until this new year... Well, I was still, so I'm going downhill!

Tilda | 16:28 | 10.02.2018

Polyoxidonium helps even if the disease has already developed. And this is what pleases me the most. Because sometimes it happens that you feel some kind of malaise and it seems that I’ll just rest for a day and everything will go away. And then you can get really sick. And then polyoxidonium comes to the rescue. So when the cold weather arrives, I always make sure that it is in my home medicine cabinet.

The product sold under this brand is a completely synthetic high-molecular compound discovered by Russian scientists in 1997 and patented by the head of the research group. According to the manufacturer, Polyoxidonium for immunity increases resistance primarily to viruses, but is also created for invasions of other types, except helminthic ones, and has almost no contraindications or side effects. It is suitable for use by children and individuals.

Description and composition

Polyoxidonium was developed and declared by the manufacturer as an immunomodulator - changing the activity indicators of certain parts of the defense, and not all at the same time, like.

In this case, those responsible for antiviral activity. The polymer compound at its base is called azoximer bromide and has the following properties:

anti-inflammatory;
immunomodulatory;
antioxidant;
detoxification agent in case of poisoning with spoiled food, poison, toxins of helminths, bacteria and other pathogens, chemotherapy drugs.

It is assumed that polycationic chains of azoximer bromide reduce the synthesis of acute phase proteins of cytokines and arrange molecules in antibody membranes into certain clusters. This changes their bilateral permeability, forcing them to work faster. Due to this, it is associated with fungi, viruses, and bacteria.

The mechanism of its action has not been studied for certain. The product has not undergone preliminary studies on humans (there is a feeling that it is being tested now, in the “field conditions” of over-the-counter sales). The composition of Polyoxidonium differs depending on the release form, but all of them contain:

crosspovidone is an absorbent with a large molecular weight that is not absorbed from the intestine;
Mannitol is a diuretic, polysaccharide in origin.

Release form

The product in any form is available with a dosage of 6 or 12 mg. The solution has a lower concentration - 3 and 6 mg. Now the manufacturer offers rectal suppositories and Polyoxidonium.

Lyophilisate for external local use and injection is available for sale - mainly at a promotional price. But on the official website of the manufacturing company, instructions for it have not been available for several years, although references to this form have been preserved.

Perhaps the dual situation is related to the recall of several batches of the Grippol vaccine that took place in 2006, which also included azoximer bromide and the rights to which belonged to its manufacturer. Almost 100 people. Acute allergic reactions to the drug were detected throughout the Russian Federation, but no deaths were recorded.

An inspection by Rospotrebnadzor confirmed the direct “participation” of the active substance Polyoxidonium in their development. And the lyophilisate implies its intramuscular administration, similar to the vaccine. There is no publicly available information about its discontinuation or revocation of its license. But the overall picture is reminiscent of attempts to quietly withdraw a compromised form from the market.

Indications and contraindications

It is officially believed that the drug can be used for children from six months of age, with autoimmune diseases, together with corticosteroids (immunosuppressants) - all categories of patients, with the exception of:

those who are allergic to azoximer bromide or excipients;
nursing mothers (due to poor knowledge of its effect on the fetus and newborn);
patients with acute renal or liver failure.

The instructions do not contain specific instructions on its use and action for hemorrhoids, hyperplasia, erosion and cervical cancer.

There are age restrictions on the use of certain forms:

tablets - not for children until the swallowing reflex is formed;
– not prescribed until the 6-year threshold;
injections of lyophilisate intramuscularly/intravenously are also indicated for ages 6 years and older.

But due to the cases of complications mentioned above, doubts arise as to how safe Polyoxidonium really is for the immune system. The instructions for use of the drug take them into account with the vague wording “rarely”, and contain an indication of possible soreness along the entire length of the muscle fiber after the injection.

And she describes suppositories and tablets as completely safe. But a number of skeptical experts point to other possible threats.

Cellular metabolism is 100% dependent on the normal structure and permeability of membranes. In particular, the high ability to change both parameters makes the spread, a solid vegetable oil with an artificially added extra carbon chain, a carcinogenic product. If azoximer bromide harms the metabolism of protective bodies in a similar way, it may be a catalyst for their malignant degeneration. And the increase in the activity of resistance agents here is explained by the loss of functionality of a significant part of them (bodies that have retained the ability to capture antigens try to compensate for their “disability”).
The autoimmune reactions provoked by it, judging by indirect and unsystematized data, are more common than indicated in the instructions. And with existing pathologies of this type, it is more likely not worth taking it than vice versa.

The long-term effects of taking Polyoxidonium are unclear. And in the short term, the mechanism of its action, which remains a mystery to science, is equally likely to turn out to be an innovation or a placebo.

Instructions for use of the drug Polyoxidonium for immunity

The rules and regimen for taking Polyoxidonium for protection differ depending on the chosen form of release and the age of the patient.

For adults

Polyoxidonium for immunity in adults is allowed 6-12 mg per day, regardless of weight.

The easiest way is with suppositories - they are administered rectally, and for those who are sexually active, vaginal use is allowed. Scheme - 1 per day, before bed, for a course of 10 days.
(from three years old) is prescribed 12 mg twice a day, 7-10 days, regardless of meals.
The lyophilisate is diluted with 1-2 ml of drinking water and allowed to swell. It is allowed to be administered into a vein - the entire dose at a time, after 1-3 days, in a course of up to 10 droppers.

For children

Polyoxidonium for immunity in children from six months to 6 years old is only dripped into or under the tongue. The daily volume of the active substance is calculated at 0.15 mg/kg body weight. The received dose is divided into two or three doses.

The solution is prepared and dosed as for adults, but is administered dropwise (into the nose, under the tongue) or intramuscularly after 1-3 days, in series of 5-10 applications. Intravenous use is not indicated until adulthood.
Polyoxidonium tablets are given at 6 mg per day, in 2 doses of 0.5 tablets, in a weekly course.
Suppositories (from the age of six) are administered according to the adult schedule, up to 10 days in a row.

Price and where to buy Polyoxidonium?

This immunomodulator belongs to the register of vital and essential drugs (vital and essential drugs) in the Russian Federation formed at the state level.

Its production is sponsored from the budget; the cost and constant availability in pharmacies is monitored by the famous Ministry of Health. You can purchase it everywhere, including on the Internet:

the price of tablets ranges from 820-832 rubles;
candles will cost 950-1160 rubles. for 10 pcs. (depending on the concentration of the active substance);
powder for preparing the solution costs 1250-1300 rubles.

Analogs

Polyoxidonium has no analogues for strengthening immune defense - neither domestic nor in the world. It is unique in its kind and is produced exclusively by LLC NMC Petrovax Pharm.

Azoximer bromide has a complex effect: immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory.

The detoxification and antioxidant properties of Azoximer bromide are largely determined by the structure and high-molecular nature of the drug.

When administered orally, Azoximer bromide also activates lymphoid cells in the intestinal lymph nodes.

Azoximer bromide blocks soluble toxic substances and microparticles, has the ability to remove toxins and heavy metal salts from the body, and inhibits lipid peroxidation, both by intercepting free radicals and by eliminating catalytically active Fe2+ ions. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Azoximer bromide is odorless and tasteless, and does not have a local irritating effect when applied to the mucous membranes of the nose and oropharynx.

Pharmacokinetics

Release form

Tablets from white with a yellowish tint to yellow with an orange tint, flat-cylindrical, chamfered, with a score line on one side and the inscription “PO” on the other side; The presence of barely noticeable inclusions of more intense color is allowed.

Excipients: mannitol, povidone, betacarotene, lactose monohydrate, potato starch, stearic acid.

10 pieces. - contour cellular packaging (1) - cardboard packs.

Dosage

Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.

Orally and sublingually 20-30 minutes before meals every day, 2 times a day: children over 10 years old and adults - 1 tablet, children from 3 to 10 years old - ½ tablet (6 mg).

If necessary, repeated courses of therapy are possible after 3-4 months. When the drug is re-prescribed, its effectiveness does not decrease.

Sublingual:

For treatment in adults:

influenza and acute respiratory infections – 1 tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - 1 tablet 2 times a day for 10 days; exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis media - 1 tablet 2 times a day for 10 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 10 days.

For treatment in children aged 3 to 10 years:

influenza and acute respiratory infections – ½ tablet 2 times a day for 7 days; inflammatory processes of the oropharynx – ½ tablet 2 times a day for 7 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - ½ tablet 2 times a day for 7 days.

influenza and acute respiratory infections – 1 tablet 2 times a day for 7 days; inflammatory processes of the oropharynx - 1 tablet 2 times a day for 7 days; exacerbations of chronic diseases of the upper respiratory tract, paranasal sinuses, chronic otitis media - 1 tablet 2 times a day for 7 days; allergic diseases (including hay fever, bronchial asthma), complicated by recurrent bacterial, fungal and viral infections - 1 tablet 2 times a day for 7 days.

For prevention in adults:

influenza and acute respiratory infections in the pre-epidemic period - 1 tablet per day for 10 days; recurrent herpetic infection of the nasal and labial area - 1 tablet 2 times a day for 10 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - 1 tablet once a day for 10 days; secondary immunodeficiencies arising due to aging or exposure to adverse factors - 1 tablet once a day for 10 days.

For prevention in children aged 3 to 10 years:

Influenza and acute respiratory infections in the pre-epidemic period - ½ tablet per day for 7 days; recurrent herpetic infection of the nasal and labial area - ½ tablet 2 times a day for 7 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear - ½ tablet once a day for 10 days.

For prevention in children over 10 years of age:

influenza and acute respiratory infections in the pre-epidemic period - 1 tablet per day for 7 days; recurrent herpetic infection of the nasal and labial area - 1 tablet 2 times a day for 7 days; exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear, 1 tablet once a day for 10 days.

oral

For treatment in adults:

For treatment in children over 10 years of age:

diseases of the upper and lower respiratory tract - 1 tablet 2 times 10 days.

Interaction

If you are taking the above or other medications (including over-the-counter medications), consult your doctor before taking Polyoxidonium.

Side effects

No side effects have been reported. If you notice any side effects not listed in the instructions, tell your doctor.

Indications

Treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology) that are not amenable to standard therapy in adults and adolescents over 12 years of age, both in the acute and remission stages.

As part of complex therapy:

acute and chronic infectious and inflammatory diseases of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;
allergic diseases complicated by recurrent bacterial, fungal and viral infections (including hay fever, bronchial asthma);
for the rehabilitation of frequently and long-term (more than 4-5 times a year) ill persons.

As monotherapy:

prevention of recurrent herpes infection;
seasonal prevention of exacerbations of chronic foci of infections of the oropharynx, paranasal sinuses, upper respiratory tract, inner and middle ear;
in immunocompromised individuals for the prevention of influenza and other acute respiratory infections in the pre-epidemic period;
for the correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors.

Contraindications

increased individual sensitivity; pregnancy, breastfeeding period; children under 3 years of age; acute renal failure; rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

Application features

Use during pregnancy and breastfeeding

The use of the drug Polyoxidonium® is contraindicated for pregnant women and women during breastfeeding (there is no clinical experience of use).

Experimental use of the drug Polyoxidonium® in animals did not reveal embryotoxic or teratogenic effects or effects on fetal development.

Before using Polyoxidonium®, if you are pregnant, or think you might be pregnant, or are planning a pregnancy, you should consult your doctor.

During breastfeeding, you should consult your doctor before using Polyoxidonium®.

About caution

If you have the diseases listed in this section, consult your doctor before starting to take the drug: chronic renal failure (used no more than 2 times a week).