Is it an analogue of duphaston. Use during pregnancy and lactation

Duphaston- An analogue of natural progesterone. Dydrogesterone in its molecular structure, chemical and pharmacological properties very close to natural progesterone. Due to the fact that dydrogesterone is not a testosterone derivative, it does not have the side effects of most synthetic progestogens, the so-called androgenic progestogens.

Dydrogesterone does not have estrogenic, androgenic, anabolic, glucocorticoid and thermogenic activity. As a progestogenic component of hormone replacement therapy (HRT), dydrogesterone helps to maintain the beneficial effect of estrogens on lipid profile blood. However, unlike estrogens, which usually negatively affect the blood coagulation system, dydrogesterone does not affect coagulation parameters. Does not render negative influence on carbohydrate metabolism and liver function.

Dydrogesterone at oral administration selectively affects the endometrium, thereby preventing increased risk development of endometrial hyperplasia and / or carcinogenesis in conditions of excess estrogens. It is indicated in all cases of endogenous progesterone deficiency.

The drug has no contraceptive action.

When treated with dydrogesterone therapeutic effect achieved without ovulation suppression or menstrual dysfunction. Dydrogesterone does possible conception and maintenance of pregnancy during treatment.

Duphaston: assistant to the desperate - Analogues

Duphaston analogue

At present, there is hardly a single pregnant woman who, for the entire period, starting from conception Conception - how life is born and ending with the birth of a child, would not take any medicines. There are many reasons for this, including environmental degradation, late childbirth, and career growth, which exhausts women both physically and emotionally. The most common problem that gynecologists are increasingly faced with is the problem of conceiving and carrying a pregnancy. A drug such as duphaston comes to the rescue. AT recent times an analogue of duphaston appeared, which has similar properties inherent in this drug- morning.

A little about progesterone

The main role of progesterone during pregnancy is to provide best conditions for conception, implantation and development of the fetal egg. Lack of progesterone leads to infertility and spontaneous abortion. Therefore, progesterone is also called the hormone of pregnancy. In addition, progesterone prepares the mucous membrane of the uterine cavity to receive a fertilized egg even before conception, and also stimulates the development of the mammary glands.

Duphaston analogue - utrozhestan

The similarity of duphaston and utrozhestan lies in the fact that both drugs have progesterone in their composition. Only in dufaston, progesterone is synthetically synthesized, while in Utrozhestan natural micronized progesterone (obtained from plant components) is contained. In addition, utrogestan has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity, which leads to termination of pregnancy.

Indications for the appointment of utrozhestan

Utrozhestan, containing progesterone in its composition, is used not only in obstetrics, but also in gynecology. The main indications for its appointment are:

the threat of termination of pregnancy;
prevention of habitual miscarriage;
premenstrual syndrome;
infertility;
climacteric disorders;
violation menstrual cycle;
mastopathy of the mammary glands;
prevention of endometriosis;
prevention of uterine fibroids.

Treatment with utrogestan during pregnancy

Utrozhestan is available in 100 mg capsules, which are used both for oral and intravaginal administration. To treat the threat of abortion, it is possible to use utrogestan by any route of administration. The most effective is a combination of oral and intravaginal administration.

The daily dose of the drug is 400-600 mg. If there is no effect from the treatment, the dose of utrogestan is increased to 800-1000 mg.

After removing the symptoms of the threat of interruption, the drug is canceled gradually, under the control of a blood progesterone test.

Disadvantages of utrogestan

Unlike duphaston, utrogestan causes side effects, such as:

dizziness;
drowsiness;
increased fatigue;
general malaise, lethargy (due to increased body temperature);
distraction and others.

Benefits of utrogestan

But, despite its side effects, utrogestan also has several advantages. Given that the drug can be taken both orally and intravaginally, it is convenient to prescribe it to women with early toxicosis. the antiandrogenic effect of utrozhestan allows the drug to be prescribed to women suffering from hyperandrogenism Hyperandrogenism . AND sedative effect funds favorably affects pregnant women. Utrozhestan also does not affect carbohydrate and lipid metabolism(does not cause weight gain) and does not contribute to fluid retention in the body.

Contraindications to the appointment of utrozhestan

The drug should not be used in the following cases:

increased blood clotting (tendency to thrombosis and thrombophlebitis);
bleeding from the genital tract of unknown origin;
having a history malignant tumors mammary glands and reproductive organs.

My mother-in-law's stepbrother is a homeopath. We once touched on the topic of progesterone deficiency in attempts to get pregnant. I told him that I also took Duphaston at the first B. Now Duf. I didn’t drink, I drank Utrozhestan. It is still more vegetable than Duf. To which he replied that all these hormones “make pigs and piglets out of women! There are other normal drugs that increase the level of progesterone, help normalize the cycle,” etc. He told me the name, I’m smart, I even wrote it down! Pascofemin.

Haven't taken them to the pharmacy yet. But I'm going.

I resorted to homeopathy only for the first time in the fall. My son and I ate small balls, increased immunity before the flu season. I must say that we never got sick at all, while our dad, who spat on it all, got sick already 3 times, and we lived, walked, breathed nearby and didn’t catch anything from him. So theoretically and a little practically, I believe in the power and effect of homeopathy.

Anyway, thank you all for the honest replies.

Duphaston. Is there a cheaper equivalent?

The Russian analogue of Duphaston is Utrozhestan herbal preparation, it also has a useful sedative effect for a pregnant woman and does not predispose to weight gain and does not affect the removal of fluid from the body, of course, Duphaston analogues are much cheaper, but it is still worth consulting with your doctor whether they should be taken.

Yes, maintaining the hormone progesterone in the body of any woman is a significant phenomenon.

And with small or insignificant indicators of this "pregnancy hormone", as many obstetricians and gynecologists call it, duphaston is very often prescribed.

You can replace or buy an analogue of duphaston!

This is UTROZHESTAN! Or - PRAGISAN!

It is these drugs that are able to cope with the task of developing and maintaining female hormone fine.

It is worth noting that it is impossible to “prescribe” medicines to oneself in any case, only a specialist can prescribe the drug.

Self-medication - can lead to an even more "confusing" picture of the medical history.

The drug "Utrozhestan" - an analogue of "Dufaston"

Recently, more and more problems associated with pregnancy have begun to arise, it is becoming more difficult for women not only to become pregnant, but also to bear a child. Perhaps this is related to large quantity abortions, or maybe our ecology is to blame. To solve these problems, such a tool as Utrozhestan, an analogue of Duphaston, is often used. Both of these drugs are hormonal, and often their appointment causes concern in women. So why are these drugs needed?

Scope of hormonal preparations

The drug "Dufaston" is prescribed to those women whose pregnancy is at risk of termination. As part of this medicine contains a component similar to the natural hormone progesterone, the lack of which can lead to miscarriage or infertility. The analogue of "Duphaston" - "Utrozhestan" - is also designed to compensate for the lack of progesterone, because if its amount in the body is normal, then the pregnancy proceeds normally. Due to the “hormone of pregnancy”, the placenta is formed, thanks to it the rejection of the fetus does not happen, pregnancy develops, the mammary glands undergo changes, the woman’s body is actively preparing for bearing, giving birth and feeding the baby.

Description of the drug "Dufaston"

This remedy is hormonal and in its action is very similar to the action natural hormone progesterone. "Dufaston" seems to make up for the missing amount of progesterone in a woman's body. The drug is synthetic, due to which its absorption occurs in digestive tract. The medicine does not disrupt the functioning of the liver, the treatment does not change the level of sugar in the woman's blood and the metabolism is not disturbed. Clinical trials passed by the drug made it possible to quite early dates use Duphaston. The doctors' comments about him are positive, and this is not surprising, because during treatment he does not affect the development of the fetus. Reception this tool does not cause drowsiness. The Russian analogue of Dufaston cannot boast of this, since the domestic drug Utrozhestan has a sedative effect, which means it causes drowsiness, so it is not recommended to drive after taking it.

The best analogue"Duphaston"

It's no secret that every year the state environment significantly worsens, which adversely affects the health of people. Without the help of medicines, many women cannot conceive and carry a child. But science does not stand still: there are many drugs that not only increase the likelihood of a desired pregnancy, but also lead to normal women Health. One of these medical "helpers" for the fair sex is the Duphaston remedy. But not only this drug helps to restore hormonal balance female body and allows you to make the dream of a crumb come true. The doctor can also prescribe an analogue of Duphaston, and more than one. But which one is better - let's try to figure it out.

Why is Duphaston so good?

Before considering which drug can be a worthy alternative to this medicine, you should understand what properties it has and how it affects the woman's body.

So, dydrogesterone, which is the basis of the drug, in terms of molecular structure, pharmacological and chemical properties close to natural progesterone. It is the deficiency of this hormone that can deprive a woman of the joy of motherhood. Despite the fact that it is a derivative of testosterone, side effects hormone does not. It is worth noting that this characteristic is a huge benefit of the drug. This cannot be said about many synthetic progestogens, which are necessary components of hormone replacement therapy. Among other things, the drug does not affect the metabolism of carbohydrates and the functioning of the liver, its action does not affect the processes of ovulation and metabolism.

Pharmacokinetics

A feature of the drug "Dufaston" is that it quickly gets out of gastrointestinal tract in bloodstream. The maximum concentration in the blood after taking the tablets is observed after 2 hours. Further, 97% of dydrogesterone binds to proteins and is hydroxylated in the liver cells.

results clinical research confirm that about 64% of the dydrogesterone dose is excreted naturally, with urine. Thanks to this, it becomes possible to determine the endogenous level of progesterone. The instruction will help to obtain more specific information about the pharmacokinetics of the drug "Dufaston".

Analogues of the drug do not have the properties mentioned above.

Indications for use

Before considering the medicines that can replace the drug "Duphaston", you should figure out what women's problems it is prescribed for.

Most often, doctors recommend taking Duphaston medicine to women who have been diagnosed with a progesterone deficiency. Low level It is this hormone in the body of a woman that is the cause of many troubles, such as the threat of fetal loss, menstrual irregularities, dysmenorrhea, premenstrual syndrome, infertility, secondary amenorrhea, dysfunctional uterine bleeding.

With all of the above ailments and conditions, doctors do not prohibit taking an analogue of Duphaston tablets, but if the budget allows, they recommend using the original drug.

How to replace the tool "Dufaston"?

To date, the most famous and most commonly used drug, which can fully replace the drug "Dufaston", is "Utrozhestan". But, fortunately, scientists did not stop at the development of only this drug. Therefore, today a woman who wants to conceive and safely endure a crumb can purchase the most suitable option from a wide range of drugs. Of course, it is worth noting that this choice should be completely made by the doctor, taking into account the individual characteristics of the patient. But situations in life are different, therefore, after consulting with a pharmacist, you can independently purchase a worthy analogue of Duphaston.

The drug "Urozhestan"

The preparation "Utrozhestan" is made on the basis of vegetable raw materials of Diogenin - a Mexican plant, better known as wild yam. It has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity. Also this Russian analogue"Duphaston" has a sedative effect useful for pregnant women, while it does not predispose to weight gain and does not affect the excretion of fluid from the body.

Advantages and disadvantages of the drug "Utrozhestan"

A distinctive negative characteristic of this drug is a significant number of side effects that are not observed when using Duphaston tablets. It could be fatigue, dizziness, drowsiness, general malaise, distraction and other reactions.

But it is worth noting that the above side effects fully compensate for the predominant characteristics of the drug. So, the medicine "Utrozhestan" can be used both orally and intravaginally. This allows you to prescribe the drug not only to pregnant women with early toxicosis, but also to achieve the maximum therapeutic result in the development of other pathologies in expectant mothers.

Attribute to the benefits of the drug can be its cost. After all, this analogue of "Duphaston" is an order of magnitude cheaper than the original. But it is worth recalling that it is strictly forbidden to replace the prescribed medicine on your own. Therefore, before buying this more affordable medication, you need to consult with your doctor, especially if we are talking about about maintaining the desired pregnancy.

Means "Dydrogesterone"

Like the drug "Dufaston", its analogues make up for the deficiency of progesterone in a woman's body. In particular, the drug "Dydrogesterone" helps to maintain the beneficial effect of estrogen on the lipid profile of the blood. The active substance of the drug does not affect coagulation parameters, as well as carbohydrate metabolism and liver function. In addition, the advantages of the drug include the absence of androgenic, estrogenic, thermogenic, corticoid or anabolic activity.

To date, the tool "Dydrogesterone" is a good and affordable Russian analogue of "Duphaston". This synthetic progestogen is indicated for endogenous progesterone deficiency.

Means "Prajisan"

This modern analogue"Duphaston" is a hormonal agent with progesterone. It is used in the treatment of long-term infertility, as well as insufficiency of the luteal phase. Effective at various violations menstruation cycle, premenopause, fibrocystic mastopathy and other ailments.

Since the drug has more wide range actions than the remedy "Dufaston", it is used only before pregnancy. Exceptions are cases where the benefit to the mother's body exceeds possible risk negative impact on the fetus.

What is the best analogue?

Only doctors have the right to talk about what medicine can replace Duphaston. Analogues of the drug are selected by a professional, taking into account all the individual characteristics of the patient and the complexity of her disease. Self appointment drugs of this group can harm the health of both the mother and the baby, and sometimes cause spontaneous abortion (with a sharp withdrawal of the remedy).

Hi friends! Today I will continue the topic of hormonal drugs, and talk about what duphaston has analogues , and how they differ.

Before talking about analogues, let me note that this medication has a whole.

Therefore, the search for existing analogues is a reasonable move for both the attending physician and the patient.

However, it is worth paying attention to one more fact ...

Duphaston analogues

From the previous article, you already know that the main active ingredient is dydrogesterone, and this is an analogue of natural progesterone.

Therefore, if we talk about the availability of drugs with the same active ingredient, then today there are no such analogues in pharmacies.

In other words, the substance dydrogesterone has its own original differences from progesterone. The main advantage is ten times less dosage is needed to achieve the same effect .

However, if we still talk about what analogues duphaston has, although somewhat conditional, it is worth noting that recently in clinical practice they began to use the drug as the main active ingredient, which is natural micronized progesterone.

In Russia it is patented as:

Prajisan,
Utrozhestan.

As it turned out, he became great alternative natural and synthetic progesterones.

The hormone in it is obtained from plant components, and it itself has antiandrogenic properties. This means that it suppresses the side effects of oxytocin that cause uterine hypertonicity.

Also, one of the most exciting issues for women is the risk of weight gain during hormone treatment.

So, neither Utrozhestan nor Prajisan can cause obesity. On the contrary, they contribute to the normalization of metabolic processes.

Do they get better from duphaston

There is an unequivocal answer to this question: reception this medication can not affect the extra pounds. Why, then, do many women complain about weight gain? Let's think logically...

Significant weight gain occurs in most women after the cessation of the menstrual cycle, when the genitals stop producing female hormones, including progesterone.

And the annotation says that dydrogesterone stimulates metabolic processes rather than suppress them. So, do all the women who take it get better from duphaston? Definitely not.

Yes, it is an obvious fact that during the period of restoration of the hormonal background, during the treatment with this drug, the appetite increases sharply.

And, given that in most cases it is prescribed for the threat of miscarriage, that is, the patient is prescribed a strict bed rest, - the effect will not keep you waiting.

But, if you subdue your appetite, and reasonably dose physical exercise, extra pounds easy to avoid. I specifically studied a lot of negative reviews, and here are my conclusions.

Duphaston negative reviews

The situation is such that reviews can be found both positive and negative. There is no overweight in either direction. Half of the women are satisfied with the results of the treatment, and note the effectiveness of the medication, as well as, as an additional effect, the improvement of the skin condition.

But there is also about duphaston negative feedback which are much more varied. Having studied them carefully, I tried to systematize the complaints. It turns out this picture:

Quite a lot of women attribute the cost of the medicine to the disadvantages, which you can learn more about in the following article. Other disadvantages include:

Sleep disturbance,
morning swelling,
Malaise and headaches
Chills and fever attacks
digestive problems,
Tachycardia,
excessive appetite,
Increase in unwanted hair.

I hope the article about what has duphaston analogues, as well as what kind of feedback it received and people's opinions, helped you learn more.

Effective and inexpensive analogues-substitutes Duphaston tablets

Duphaston is synthetic medical device hormonal plan, the composition of which is a full-fledged analogue of the key female secret responsible for the process of childbearing. Many can meet with its deficiency and, accordingly, infertility and other gynecological ailments of the genital area. Pharmaceutical products that resist diseases of this group have impressive price tags, but the pharmacy market has a number of generics at a more affordable cost.

Pharmacological property and pharmacodynamics

The active substance of the studied pharmaceutical product is Dydrogesterone. Its molecular structure, chemical and other properties almost completely coincide with the natural female hormone responsible for the processes of pregnancy and the birth of a child directly - progesterone.

The active ingredient of the drug is characterized by the absence of androgenic, estrogenic, thermogenic, anabolic and glucocorticoid properties. In addition, it does not harm the exchange nutrients, especially carbohydrates and does not depress the functioning of the liver. He also carries out positive impact on lipid profiles.

In what cases is the drug used?

Indications for use:

The presence of a lack of the hormone progesterone, which prepares a woman for childbearing;
Growth of the inner layer of the walls of the uterus;
infertility;
Risk of miscarriage;
Destabilization of menstruation cycles, their absence.

Who is not being issued?

Application during pregnancy

Sometimes it happens that a woman cannot become pregnant, and there is also a risk of losing a child due to a lack of a female hormone called progesterone in the body. It is to prevent such a tragedy that doctors often recommend an artificial substitute for this key hormone in the form of the drug in question.

The active ingredient almost completely coincides with the substance natural origin. When it enters the body of a woman, it is able to completely replace it. Normally, progesterone must be produced by the ovaries along with estrogen and form the uterine mucosa, which definitely changes during the monthly cycles.

During menstruation, progesterone is not expressed in the blood as much as estrogen, which helps uterine cells multiply and grow. On the days of the onset of the release of a mature egg from the ovaries, a temporary gland is formed that is responsible for the production of progesterone, called corpus luteum. A change in the concentration of this hormone can change the uterine mucosa, giving it friability, which prevents cell growth and promotes the appearance of a number of vessels. This process is very important during the fertilization of the egg, as it will be able to receive the most important nutrition for it.

That is why Duphaston is prescribed to women who fail to become mothers.

Drug absorption

The use of this pharmaceutical product can provoke some concomitant negative phenomena:

Hematopoiesis: pathology affecting erythrocytes, namely the reduction of their life cycle;
Immune system and integuments of the skin: hypersensitivity reactions in the form of rash and urticaria;
Central nervous system: pain in the head;
reproductive system: bleeding from the uterus.

How to carry out the healing process?

The prescribed dosage of the medication directly depends on the existing ailment:

The presence of proliferation of uterine tissues - 10 mg from 5 to 25 days of the cycle from 2 to 3 times a day;
decline negative impacts PMS - 10 mg twice a day from the 11th to the 25th day of the cycle;
Stop bleeding - 10 mg per day for a week;
Infertility - 10 mg from the 14th to the 25th day of the menstrual cycle. The duration of therapy should be at least 3 months and not more than six months;
Prevention of premature childbearing - a single dose of 40 mg of the drug. After that - 10 mg every eight hours;
Normalization of menstruation - 10 mg from 11 to 25 days of the cycle.

Consequences of overdosing

Data on the symptoms of overdose are not available. With an extremely large dose used, it is recommended to carry out a gastric lavage.

Important points of therapy

Some patients may experience breakthrough bleeding. They are eliminated by increasing the dosage of the drug;
Before implementation medical process, in without fail need to go deep medical examination, including examination by a qualified gynecologist and mammologist;
The drug is allowed to be taken by the manager of transport and other units, since it does not adversely affect the speed of decision-making.

How much does Dufaston cost: price in a pharmacy

The medication can be purchased at the nearest pharmacy, but this will require a medical prescription. According to one of the largest website selling pharmaceuticals, the cost of a pharmaceutical product can reach up to 737 rubles.

List of Russian and foreign similar medicines at low cost

Progesterone - (production - Russia)

It is indicated in the presence of uterine hemorrhages, the absence of regular menstruation and spontaneous abortion.

Not used in patients with severe hepatic and renal dysfunction, thromboembolic disease, vaginal bleeding, of unknown origin, oncological lesion epithelial cells skin mammary glands. AT extreme cases and only after consulting a doctor is it possible to use the medication. You need to be especially careful with heart and vascular diseases, diabetes, asthma and epilepsy.

Possibly an increase blood pressure, which is the most common occurrence. Rarely enough, vomiting, decreased sexual desire, a feeling of chest tightness, headaches and depressive states can occur.

Utrozhestan - (Thailand)

It is allowed for both oral and intravaginal use. In the first case, the medicine can prevent the risk of miscarriage, infertility, prevent the development premenstrual syndromes and treat a breast cyst. When injected into the vagina, Utrozhestan is recommended for ovarian dysfunction, premature menopause, and those who may give birth prematurely.

It is forbidden for those who do not tolerate the constituent components of the pharmaceutical product, who have thrombotic diseases, bleeding from the vagina of an undetermined origin, oncology of the liver, breast and genital organs, as well as minors and those who are in the period breastfeeding. The medical product is not recommended for last dates pregnancy.

At the same time, malfunctions of the reproductive system, problems with a stable menstrual cycle are allowed. Sometimes there are pains in the head, craving for sleep and skin rashes with itching.

Iprojin - (France)

Like the previous generic, this french drug can be taken orally or inserted into the vagina. In both cases, Iprozhin effectively copes with the syndromes that occur before menstruation, fibrocystic mastopathy. It is in his competence to prevent endocrine infertility, premature birth and development benign tumors uterus.

It is necessary to refuse to take the medicine for those who do not absorb its constituent substances, with unclear reasons for the discharge of blood from the genital organ, malignant tumors in the reproductive system and mammary glands. Patients with severe malfunctions of the heart, kidneys, asthma, epilepsy and diabetes should be especially careful. In addition, therapy in the lactation period is not recommended.

Side effects occur infrequently. The most possible are minor allergies, feeling tired and wanting to go to sleep, temporary dizziness and an unstable menstrual cycle.

Prajisan - (the most affordable substitute for India production)

Despite the significantly distinguished low cost, it provides effective treatment female infertility, which is caused by luteal insufficiency, facilitates the course of the premenstrual period and helps to stabilize the cycle. Thus, by paying little money, you can get a similar pharmaceutical effect.

Contraindications are completely identical to all the medicines discussed above.

Parallel reactions of a harmful nature are extremely rare. Provoke tension of the mammary glands, excessive desire for sleep, periodic vestibular disorders, nausea and skin rash, can only be a long process of treatment.

Conclusion on Inexpensive Generics

Studied European medicinal product that has a positive effect on reproductive system representatives of the fair sex. On the Russian market, without special problems you can pick up a similar substitute - many companies and pharmaceutical manufacturers (mostly foreign) are engaged in the production of economically affordable synonyms. At first glance, it may seem that the selection of a substitute is not so difficult task. However, the decision of this issue should be delegated to a qualified doctor. It is he who must prescribe a certain drug.

Infertility is dangerous diagnosis and a terrible sentence for every woman who sees her future in happy motherhood. In the treatment of this disease, in some cases, the question arises of what can replace Duphaston, but what is the reason for this?

The essence of the problem

Before talking about correction hormonal regimen treatment, it is necessary to recall that Duphaston has practically no contraindications, and is approved for use by all women, with the exception of patients with increased intolerance to the active components. Such cases are extremely rare, but nevertheless, in practice, obstetrics have been recorded more than once. In addition, it is worth noting that this particular drug does not always help in the treatment of infertility, for example, six-month therapy with low efficiency requires immediate correction.

If the problem is ovulation or her total absence, then the female body needs additional progesterone, which is produced in not enough. That is why it is required to additionally take Duphaston or another analogue for the timely regulation of the hormonal background, the menstrual cycle and successful ovulation.

Worthy analogue

Many patients ask the standard question, is it possible to replace Duphaston with Utrozhestan? Most often, the answer is yes, since the characteristic drug has a similar composition, pharmacological effects to the site of pathology. But what is known about this medical preparation? Unlike Duphaston, progesterone in chemical formula not synthesized, but presented in in kind which increases the chances of successful conception.

The use of a characteristic medication is appropriate not only in obstetrics, but also in modern gynecology, and among the indications, not only diagnosed infertility is distinguished, but also others no less dangerous diseases. Among those are the following:

threat and prevention of miscarriage;
menopause and climate syndrome;
mastopathy of the mammary glands;
premenstrual syndrome;
disturbed menstrual cycle;
endometriosis and its prevention;
prevention of uterine fibroids.

Contraindications and side effects

Utrozhestan gently acts in the female body, and among the contraindications, the instructions indicate hypersensitivity and lactation. It is also not recommended to take the drug with a tendency to uterine bleeding, with suspicion of malignant neoplasms, as well as in case of impaired blood clotting. This is where the list of restrictions ends, but side effects are quite common, and on numerous sites on the network, patients reflect in detail all their dissatisfaction with such an appointment.

Most often, anomalies prevail at the very beginning of the intake, when the body is just getting used to an additional source of progesterone, and is not always ready for such radical changes. Doctors distinguish the following anomalies that progress in especially weakened organic resources:

frequent dizziness, less often - fainting;
increased drowsiness;
nervous excitement;
skin rash;
headache attacks, migraine;
angioedema;
hemolytic anemia;
hives and itching;
passivity and decline in performance;
distracted attention;
signs of dyspepsia;
depressed state.

If there are characteristic anomalies, you should not rush to stop the drug, perhaps a dose adjustment is enough to achieve positive dynamics of the disease. Otherwise, a replacement will be required, and the effect of a new analogue in the body is the most unpredictable.

Dosage and administration

the medical preparation Available in the form of capsules intended for oral and vaginal use. One pill contains 100 mg of natural progesterone, but the method of application is discussed individually by the attending gynecologist.

In order to prevent a particular diagnosis, the specialist recommends internal reception hormone, and the prescribed daily allowance is very important to maintain. If this is a treatment for diagnosed infertility, then doctors also stop at oral administration of Utrozhestan. But to maintain pregnancy with a threat of miscarriage, it is preferable vaginal use capsules, but internal intake in the complex also does not hurt.

Utrozhestan has a lot of advantages, and such advantages are hard to deny. For example, with early toxicosis of a pregnant woman, it is better to insert the capsules vaginally, and the therapeutic effect is identical. In addition, the sedative effect has a positive effect on the excited nervous system, and progesterone also helps to eliminate congestion in the female body.

It is very important that the drug corresponds to the expiration date, and was prescribed by a doctor, and not by a girlfriend following her example. The effectiveness is noticeable after 2-3 months of regular use, however, each patient has her own individual characteristics treatment.

Other analogues

If, according to the indications, Duphaston is suitable, but contraindications limit its systematic use, then in addition to the hormonal drug Utrozhestan, there are other sensational analogues that are also effective in the presented clinical pictures. But what kind of drugs are we talking about?

Most often these are such names as Utrozhestan and Prajistan, which are considered a worthy alternative to enough synthetic progesterone, necessary for the correction of the menstrual cycle, hormonal levels and providing successful conception. These preparations are patented in Russia and are widely used in gynecological and obstetric practice show a stable therapeutic effect even in seemingly hopeless clinical situations.

If the medical drug Duphaston is not suitable, the patient should not engage in superficial self-medication, since the positive dynamics of the underlying disease will still not wait. First of all, you need to contact a specialist, and that clinically will select the most effective replacement, a worthy analogue. There is no complete analogue of the characteristic medicines, and it is important not to forget about this when correcting the treatment regimen.

It remains only to add that all the presented medicines have a hormonal basis, that is, they have a direct effect on hormonal background. That is why one should not exclude such anomalies as unexpected weight gain, increased vegetation on the body. It is important to note this question in order to keep the form, presentable appearance. However, such cases are very rare, so the patient may not worry about common fears in terms of taking "hormones".

If absolutely contraindicated for use hormonal drug Duphaston, what can replace such an appointment will only be prompted by the attending physician - a gynecologist. If such a replacement is required when carrying a fetus to preserve its viability, then this should definitely be the Utrozhestan medication, which is dispensed without an additional prescription. The characteristic preparation can be taken orally and vaginally, which will markedly enhance the desired therapeutic effect.

Duphaston is a hormonal drug that was released on pharmaceutical market in 1961. It was released by the Solvay company (Netherlands). It was the first oral progestogen. The main feature of this medication is that it contributes to the metabolic stability of the female body, without causing changes in estrogenic, androgenic and mineralocorticoid metabolism. Duphaston practically does not cause side effects, and is well tolerated by patients. Its main area of application is obstetrics and gynecology. Also, the tool is used in auxiliary reproductive technologies.

The drug does not inhibit ovulation and, therefore, the ability to fertilize in women taking it does not change. The active ingredients selectively affect the endometrium, vaginal mucosa and cervical canal.

Dufaston is indispensable in the treatment of miscarriage, dysfunctional uterine bleeding, endometriosis, infertility and in assisted reproductive technologies (IVF). Duphaston has both expensive and cheap analogues. You can replace it with one of them, but before that, it is imperative to consult a doctor.

Duphaston is today considered one of the most expensive progesterone preparations. Some patients, considering high price on it, they turn to the doctor with a request to replace it with cheap analogues. The following substitutes for Duphaston are presented in the pharmacy network:

Injesta.
Iprozhin.
Oxyprogesterone capronate.
Prajisan.
Progesterone.
Utrozhestan.

All of these products are available for oral and vaginal use. Detailed dosage, form of release and quantity in the package are presented in the table. The price of these medicines (drugs) in Russian pharmacies is slightly different.

injesta

The drug belongs to the pharmacotherapeutic group of gestagens. Main active substance- progesterone, which is a hormone of the corpus luteum. Injesta favorably affects the process of implantation of a fertilized egg and supports normal development embryo in the first half of pregnancy. This is due to the fact that it transforms the proliferation phase of the endometrium during the secretory phase, which is essential for physiological reproductive function. reducing excitability and contractility myometrium, it stops and prevents the process of abortion.

Indications are the following conditions:

amenorrhea;
uterine bleeding;
infertility associated with a violation in the endocrine system;
miscarriage;
menstrual irregularities varying degrees severity (for example, algomenorrhea).

The drug can be administered in two ways: intramuscular or subcutaneous. Dosage and duration of use is determined by the indications. To prevent the threat of abortion (if there is low scores progesterone in the blood) or treatment of a threatened abortion that has already begun, use 15-25 mg of Injesta daily until the symptoms disappear completely. If, in connection with the anamnestic data, a diagnosis of "recurrent miscarriage" is made, then the drug should be administered every other day until the fourth month of pregnancy.

With irregular uterine bleeding 10 mg is administered daily for 7 days. If curettage was performed before the diagnosis, then Injesta can only be used 2 weeks after the procedure. If there is a need for immediate use of the drug, then 15 mg is administered for 6 days.

The drug is not used in pediatric practice and in patients with severe cardiovascular pathology, including arterial hypertension, and during pregnancy for more than 36 weeks.

Iprozhin

The basis of the drug is micronized progesterone, which has the ability to interact with the surface receptors of the uterus, penetrates into their nucleus, where it activates the organ's DNA and stimulates its RNA. Through these processes, the uterine mucosa passes from proliferative phase into the secretory, thus creating favorable conditions for implantation of the fetal egg in the uterine cavity. The drug has a relaxing effect on the muscle fibers of the myometrium and fallopian tubes preventing abortion. In addition, Iprozhin induces lactation.

The medication can be used both orally and intravaginally, by injecting deep into the posterior fornix of the vagina. In the first case of application, the active ingredients reach their peak 2-3 hours after ingestion, in the second - after an hour. The frequency of admission - twice a day during the first trimester of pregnancy. The dosage (100 or 200 mg) can only be determined by a gynecologist, since it all depends on the laboratory parameters of the level of progesterone in the blood of each individual patient.

The drug is indicated for such pathologies:

substitution hormone therapy in case of non-functioning ovaries or their complete absence;
preparation for in vitro fertilization in order to maintain the luteal phase;
prevention and treatment of miscarriage;
infertility;
endometriosis of the uterus;
prevention of tumor neoplasms of the uterus.

It is forbidden to use Iprozhin in the presence of:

allergies to Iprozhin components;
uterine bleeding of unspecified origin;
delays of parts of the embryo in the uterine cavity;
malignant tumors of the uterus, ovaries or breast;
severe heart disease;
hepatic/renal failure.

A feature of the use of Iprozhin is that it can cause disturbances in the liver. In this regard, it is necessary to periodically monitor the activity of liver enzymes.

Oxyprogesterone capronate

The active basis of the drug is active ingredient hydroprogesterone capronate. The composition also includes olive oil refined benzyl benzoate. The drug belongs to the group of hormones of the gonads and drugs used in the pathology of the genital area. Produced by PAT "Biopharma" (Ukraine).

The active substance of the drug chemical structure is a synthetic analogue of human progesterone. Its mechanism of action is similar to natural progesterone: it improves proliferative properties endometrium of the uterus, reduces its excitability, stimulates the preparation of the mammary gland for lactation. It is more stable in the body, so its effect persists for a long time.

Oxyprogesterone is administered intramuscularly, slowly, in the presence of such disorders:

deviations associated with insufficient work of the corpus luteum;
threatened abortion;
primary or secondary amenorrhea;
intermenstrual uterine bleeding;
hyperplastic processes in the endometrium of the uterus, including endometriosis.

You can not use the medication for treatment in such cases:

there is an allergy to the components of oxyprogesterone capronate;
gestational age more than 24 weeks;
pregnancy does not develop;
a history of cholestatic jaundice or renal failure;
suspected malignant neoplasms genital organs;
severe thrombophlebitis or thromboembolism pulmonary artery in history.

Before use, the ampoule with the drug must be warmed to room temperature. In threatened abortion, the dose of administration is 250 mg once a week. If hypertrophic processes in the uterus are being treated, then in this case only 2 ml of a 12.5% solution is used from the 5th to the 25th day of the menstrual cycle. Do not mix the drug with others in the same syringe.

Prajisan

In each of the forms of release of the drug active ingredient progesterone appears. It has the ability to interact with the surface receptors of the uterus, penetrates into their nucleus, where it activates the DNA of the organ and stimulates its RNA. Thanks to these processes, the uterine mucosa passes from the proliferative phase to the secretory one, thus creating favorable conditions for the implantation of the fetal egg in the uterine cavity. It has a calming effect on the muscle fibers of the myometrium and fallopian tubes, preventing abortion. Produced by an Indian pharmaceutical company.

Pharmacokinetic properties are no different from previous drugs. It selectively accumulates in the uterine cavity, from where it is slowly absorbed into circulatory system, where it reaches its peak an hour after ingestion. Metabolized in the liver and excreted in the urine. It is used for any deviations associated with a violation of the course of the luteal phase, namely:

HRT with dysfunction or absence of the ovaries;
during preparation for IVF in order to normalize the course of the luteal phase;
prevention and treatment of miscarriage;
infertility of endocrine etiology;
endometriosis;
prevention of tumor neoplasms of the uterus;
egg donation program.

Assignment restrictions are the following states:

coagulopathy varying degrees gravity;
bleeding from the genital tract of unknown origin;
porphyria;
retention of parts of the embryo after an abortion;
allergic reaction to the drug.

Both capsules and gel are injected deep into the posterior fornix of the vagina twice a day ( daily dose can range from 200 to 400 mg) with the threat of miscarriage. For infertility therapy, one applicator of Prajisan gel is used and administered daily from the day of ovulation or from the 17th to the 20th day of the cycle for a week. For hygienic reasons, the applicator in medicine It is disposable and must be disposed of after use.

Progesterone

Refers to the hormones of the gonads (gestagens) produced by the corpus luteum of the ovaries. By analogy, its basis is progesterone. The drug is injectable. Produced in Russia and Ukraine. it hormonal remedy favorably affects the process of implantation of a fertilized egg and supports the normal development of the fetal egg until the 12th week of gestation. This is due to the fact that it transforms the proliferation phase of the endometrium during the secretory phase, which is essential for physiological reproductive function. By reducing the excitability and contractility of the myometrium, it stops and prevents the process of abortion.

The drug is administered intramuscularly or subcutaneously. Before the injection, given that it will inject oil solution, the ampoule must be heated in a water bath to a temperature of 30 degrees. If the solution begins to crystallize, then heating should be continued until the precipitate is completely dissolved.

For bleeding, use 15 mg daily for a week. If curettage was performed before the diagnosis, then Progesterone can be used only 3 weeks after the procedure. If there is a need for immediate use of the drug, then 15 mg is administered for 6 days.

With an overdose of the drug, there are unwanted effects in the form of nausea, vomiting, dizziness, shortness of breath, blurred vision, sweating, feeling hot, etc. At slightest symptoms you should inform the doctor who will replace the drug with a similar one or cancel it altogether.

Main indications for use:

amenorrhea;
intermenstrual bleeding;
infertility associated with the endocrine system;
miscarriage;
menstrual disorders of varying severity (oligomenorrhea, algomenorrhea).

Utrozhestan

Utrozhestan is the most commonly used analogue of Duphaston, which is also several times cheaper than it. Structural formula this medication based on the properties of micronized progesterone, which normalizes the secretory function of the endometrium in women reproductive age and promotes regeneration processes inner surface uterus after surgical interventions(scraping). It also prevents the progression of endometriosis, has a calming effect on the myometrium.

It is especially important that Utrozhestan does not androgenic activity. In numerous clinical trials, its ability to influence the release of luteinizing and follicle-stimulating hormones by the hypothalamus has been proven. In practice, Utrozhestan shows good performance normalization of plasma progesterone levels. It is provided for all of the above obstetric and gynecological conditions associated with insufficiency of the luteal phase of the cycle.

It can be used both vaginally and orally necessary quantity water. Take, depending on the dosage prescribed by the doctor, twice a day until the term of full-term pregnancy. In other cases, the frequency and time of admission should be adjusted by the obstetrician-gynecologist, depending on the woman's menstrual cycle.