Amitriptyline is related. Amitriptyline - emergency or extreme case

Dosage form: Film-coated tablets, blue, with a biconvex surface, scored on one side.

Read the entire package leaflet carefully before taking this medicine:

Do not throw away this leaflet. It may be necessary to re-read it.

If you have any questions, ask your doctor or pharmacist.

This medicine must be prescribed by your doctor. Do not pass it on to others. It can harm them even if their symptoms are the same as yours.

If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

What is Amitriptyline and what it is used for: Each tablet of Amitriptyline contains the active substance - amitriptyline hydrochloride, 25 mg, and excipients: lactose, corn starch, dibasic calcium phosphate, gelatin, talc, magnesium stearate, colloidal anhydrous silicon dioxide, polyethylene glycol 6000, Opadry Blue (hydroxypropyl methylcellulose, titanium dioxide (E 171), talc, polyethylene glycol, brilliant blue (E 133)).

Belongs to the group of antidepressants, has a sedative effect, improves mood, helps to eliminate bedwetting.

Amitriptyline is used in the following cases:

severe depression, especially with characteristic signs of anxiety, agitation and sleep disturbances;

nocturnal enuresis in children in the absence of organic pathology.

Do not take Amitriptyline if:

hypersensitivity to amitriptyline or to any of the components of this drug;

angle-closure glaucoma;

violation of urodynamics due to prostatic hypertrophy or atony of the bladder;

recent myocardial infarction, violation of conduction or heart rhythm, insufficiency of the coronary arteries;

simultaneous reception with MAO inhibitors, sultopride.

Before prescribing Amitriptyline, be sure to inform your doctor about the following changes in your health:

tendency to develop orthostatic hypotension and sedation during treatment with amitriptyline;

chronic constipation;

prostatic hyperplasia;

diseases of the cardiovascular system;

hypothyroidism, taking thyroid hormone preparations;

liver or kidney failure.

When prescribing Amitriptyline, be sure to inform your doctor about taking any of the following medicines:

Antihypertensive drugs - for the treatment of hypertension;

Atropine and other atropine-like substances (sedative H1-histamine, antiparkinsonian, anticholinergic, antispasmodic atropine drugs, disopyramide, phenothiazine antipsychotics) - for the treatment of allergies, Parkinson's disease, eye diseases, mental disorders.

Central nervous system depressants (morphine derivatives - analgesics, antitussives; barbiturates, benzdiazepines; anxiolytics; sedative antidepressants (doxypin, miaserin, mirtazapine, trimipramine), neuroleptics; sedative H1 - antihistamines; centrally acting antihypertensives; thalidomide) - for pain relief, treatment of cough, depression, allergies, hypertension.

Baclofen is a muscle relaxant.

Beta-blockers (bisoprolol, carvedilol, metoprolol) - for the treatment of heart disease.

Combinations of Amitriptyline with certain drugs are undesirable, require medical supervision and dose adjustment of drugs:

Medicines containing alcohol.

Clonidine, guanfacine - for the treatment of hypertension.

Selective MAO inhibitors (moclobemide, toloxatone) - for the treatment of depression.

Linezolid - to treat infections.

Alpha and beta sympathomimetics (epinephrine, norepinephrine, epinephrine, norepinephrine, systemic dopamine for the parenteral route of administration).

Antiepileptic drugs, incl. carbamazepine, valproic acid, valpromide - for the treatment of epilepsy.

Antidepressants - selective serotonin reuptake inhibitors (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline).

Alpha and beta - sympathomimetics (adrenaline, epinephrine as a local hemostatic agent and for subcutaneous / subbucal injections).

Phenothiazides (thioridazine) - for the treatment of mental disorders.

Co-administration of Amitriptyline and the following medicines is contraindicated:

Non-selective monoamine oxidase inhibitors (MAOIs) - for the treatment of depression, anxiety disorders and other diseases.

Sultopride - for the treatment of mental disorders.

The use of Amitriptyline during pregnancy and lactation:

Taking amitriptyline during pregnancy is possible under medical supervision only in cases where the expected benefit to the mother outweighs the possible risk to the fetus. If therapy with amitriptyline is necessary to maintain the mental health of the mother, treatment with the drug at an effective dose can be continued throughout pregnancy. There may be some side effects in newborns that appear in the first days of life and, as a rule, are short and not severe. Be sure to warn the doctor about taking amitriptyline: monitoring and care of newborns is carried out taking into account the above effects.

Amitriptyline passes into breast milk. If necessary, treatment with the drug during lactation, breastfeeding should be interrupted.

The ability of Amitriptyline to influence the management of vehicles and other mechanisms: the drug may reduce the ability to drive a car and other mechanisms, which must be taken into account.

The dose of the drug is determined by the doctor. Take during or after meals with water. To improve sleep, the drug can be taken in the evening. Increasing the dose is usually carried out by taking the drug in the evening or at bedtime. With maintenance therapy, it is possible to take 1 time per day. Cancellation of the drug is carried out gradually under the supervision of a physician.

The notch on the tablet is intended solely to facilitate patient intake.

Depression. Treatment begins with low doses with a gradual increase under the close supervision of a physician to assess the effectiveness and tolerability of therapy.

Usually the dose is 75-150 mg per day, higher doses are used in a hospital setting. The average daily dose in adults is usually 75 mg (25 mg 3 times a day). After 3 weeks of effective treatment, the daily dose may be individually reviewed.

In children, the effective daily dose is not more than 1 mg/kg of body weight.

Treatment with antidepressants is symptomatic. The duration of treatment is about 6 months in order to prevent relapse.

Nocturnal enuresis in children. Doses of amitriptyline used for enuresis are lower than for the treatment of depression. The daily dose in children aged 6 to 10 years with a body weight of 25 kg or more is 25 mg per day (1 tablet), from 11 to 16 years - 25-50 mg per day (1-2 tablets).

The drug is taken at bedtime. The duration of therapy is not more than 3 months.

Special categories of patients. In patients over the age of 65, the initial dose should be reduced (up to 50% of the minimum). The daily dose can be divided into several doses or taken once at bedtime. If necessary, increasing the dose is carried out gradually, under close medical supervision due to the possibility of serious side effects in this category of patients (fainting, confusion). With impaired liver and kidney function, careful selection of an individual dose is recommended, which can be reduced compared to patients with normal function of these organs.

If you have taken a higher dose of Amitriptyline than your doctor recommended: If the number of tablets per day that you have taken exceeds the number recommended by your doctor, or your child has swallowed the tablets, contact your doctor immediately or call an ambulance! Stop taking the medicine immediately! Overdose symptoms are likely to be manifested by dry mouth, accommodation disorders, tachycardia, cardiac arrhythmias, decreased blood pressure, increased sweating, urinary retention. Possible confusion, coma. As a first aid, carry out the following activities: gastric lavage, taking a suspension of activated charcoal, laxatives, maintaining body temperature, monitoring blood pressure, ECG.

If you forget to take your next dose of Amitriptyline on time: Take the pill as soon as you remember, making sure there is time before the next dose. If there is little time before the next dose, take as directed by your doctor. Do not take a double dose if you miss the next dose!

Possible adverse reactions::

Amitriptyline may cause side effects similar to those that occur with other tricyclic antidepressants. Some of the side effects listed below (headache, tremors, impaired concentration, constipation, and decreased libido) may also be symptoms of depression and subside as the depressive state is relieved.

dry mouth, constipation, accommodation disorders, tachycardia, increased sweating, urinary retention;

orthostatic hypotension, decreased sexual function;

drowsiness or sedation, tremor, seizures in predisposed persons, confusion, loss of consciousness, dysarthria;

the risk of developing suicidal behavior / thoughts, mood changes with the advent of a manic episode, manifestations of anxiety;

weight gain;

• violation of conduction and heart rhythm (in high doses);

  breast enlargement, secretion of milk from the mammary glands;

allergic skin reactions;

• an increase in the number of eosinophils, a decrease in the number of leukocytes and platelets in the blood.

Adverse reactions in elderly patients. In patients aged 50 years and older, an increased risk of bone fractures has been identified when taking selective serotonin reuptake inhibitors or tricyclic antidepressants. The mechanism of this side effect has not been elucidated.

Special precautions while using amitriptyline:

Depression is associated with an increased risk of suicidal behavior, auto-aggression, and suicide. Such a risk may exist up to the achievement of a stable remission and occur spontaneously during the entire course of therapy, especially in the early stages of remission or when the dosage is changed. When treating with antidepressants, it is necessary to carefully monitor your condition, especially at the beginning of therapy: changes in mood, behavior, clinical deterioration and / or the appearance of suicidal thoughts, the development of side effects. Ask your loved ones to help you evaluate your condition during treatment. In case of any change in the condition, doubt in its assessment, please consult a doctor or inform your loved ones!

If insomnia or nervousness appears at the beginning of treatment, it is recommended to consult a doctor in order to reduce the dose of the drug and carry out the necessary symptomatic treatment.

In patients suffering from manic-depressive disorders, the course of the disease may worsen. Amitriptyline should be discontinued and a doctor should be consulted for appropriate treatment.

In patients with epilepsy, amitriptyline may reduce the seizure threshold while taking amitriptyline. With the development of seizures, amitriptyline should be discontinued. Seek medical attention for appropriate treatment.

When you stop taking the drug, there are rare signs of a withdrawal syndrome (headache, malaise, nausea, anxiety, sleep disturbances), to prevent which a gradual (over several weeks) dose reduction is necessary with careful monitoring of the condition.

The drug is used with caution in elderly patients.

Due to the presence of lactose in the medicinal product, the drug is contraindicated in persons with congenital galactosemia, malabsorption of glucose and galactose or lactose deficiency.

Storage conditions:

Store in a place protected from moisture and light at a temperature not exceeding 25C.

Keep out of the reach of children.

Package: 50 tablets in polymer jars or 10 tablets in a blister pack. One jar or 5 blisters, together with a leaflet, is placed in a cardboard box.

Best before date: 3 years.

Leave conditions: By prescription

Manufacturer information:

Belarusian-Dutch joint venture limited liability company "Pharmland", Republic of Belarus, Minsk region, Nesvizh, st. Leninskaya, 124, building 3

Amitriptyline is a prescription drug, it is dispensed by prescription, and not always adequate people take it (well, that's why it is an antidepressant). My friend, who works as a pharmacist in a pharmacy, told me one "New Year's story" that happened in a pharmacy. On the thirty-first of December, the pharmacy worked until nineteen o'clock in the evening, the clock showed eighteen-fifteen, the pharmacists eagerly awaited the end of the working day, the last of this year.
A man came and asked for amitriptyline, he didn’t have a prescription, but on New Year’s Eve he didn’t want to argue with anyone and he was given the drug. Five minutes later, this man runs into the pharmacy, shouting that they gave him something wrong (he needed amitriptyline trihydrate - and different factories do the same thing under different labels), he was very angry, shouted and broke the window. As a result, the girls on New Year's Eve - a call to the police, an explanation with the authorities, a spoiled mood.

Conclusion - prescription drugs should be dispensed by prescription, there are enough psychos now.
The most interesting thing is that this man did not stop going to the pharmacy, but rather became her regular customer and behaves adequately, maybe amitriptyline helps, maybe he switched to something stronger.
Take care of your nerves!

I was prescribed amitriptyline by a neurologist for migraine. I took it for a month. She walked like a sleepy fly. After the end of such a course, I did not notice that migraine attacks of Headache became less frequent. The head continues to hurt. Apparently migraines are permanent and there is no cure.

I have known about Amitriptyline for a long time, mainly as a sleeping pill. I have a friend who, as soon as she gets insomnia, swallows a pill and recommends it to others.

I read about its antidepressant effect and really hoped for it, but it turned out to be in vain.

But few people know that Amitriptyline is also a remedy used for chronic pain.

It was on this occasion that he was prescribed to me in conjunction with other drugs for back pain.

In addition to back pain, I suffer from depression, but Amitriptyline did not seem to be aware of it ... My mood even worsened from it, I don’t know if it was connected with it or not, but interruptions in the work of the heart began.

I felt terrible, after taking it and the next day the state was like "in the bank", drowsiness is terrible, but that's not all. Another young girl took it with me, so after a week of taking it she could not get up to "urinate"! Even after discontinuation of the drug, this was not done immediately, a catheter was inserted.

Another friend of mine gained a lot of weight on Amitriptyline, although she used it in smaller dosages than prescribed.

After a close acquaintance with this drug, antidepressants are a frightening word for me ... But it's up to you. Health without pills to everyone who came into my review!

They prescribed this drug to me when I got into neurology, because I was afraid of seizures. The last year was very stressful (as they explained to me, "due to the fact that I'm afraid, the limbs begin to twist) When I started taking it, half a pill in the morning and in the evening after eating, I slept constantly for the first few days. Sometimes it even seemed that I couldn’t get up and seemed to fall asleep again. Then it seemed to get better. leave a lot of money, but you have to go, I'll explain why.

Recently, I have become very nervous, depressive, my hands seem to be shaking a little and always tired, I want to sleep during the day, and the most unpleasant thing of the last 10 days, the root of the tongue began to go numb, and today in particular. I started digging the side effects of this blood pressure and found ( maybe numb and not because of him, but too many sources confirm this side effect from amitriptyline). On Monday I will go to a neurologist to clarify my further actions and add more information. To be honest, I'm afraid to take it already, although the daily dose has decreased to 0.75 tablets / day.

Advantages:

Flaws:

Did not help, side effects.

In this review, I want to talk about a drug called "Amitriptyline." In my student years, I suffered from vegetative-vascular dystonia, and throughout this illness, they probably managed to test a large number of drugs on me. So Amitriptyline turned out to be one of them.
The drug was prescribed one tablet per day. I drank it for 10 days. There was nothing more than negative feelings. Everything I came with didn't work. Dizziness, headaches and apathy remained, but they were accompanied by severe drowsiness and a feeling of fog in the head. A couple of days after the drug was discontinued, everything went away.
Maybe the drug just didn't work. Or all the same, such diseases need to be treated in other ways, so as not to experience side effects.

Neutral Feedback

If this depression didn’t scare everyone so much ...

Advantages:

price, quantity per pack, fast action, high efficiency

Flaws:

unpleasant taste, many contraindications, pronounced side effects, caution is required, not compatible with all drugs, the likelihood of withdrawal syndrome

Review:

I recently started taking amitriptyline. It is a tricyclic antidepressant. I can't say that I definitely have depression. But on the Internet, I found information that this tool eliminates the feeling of anxiety. Although the drug in question is available by prescription, if you believe the instructions, you can buy it without a prescription. It will not be difficult to do this. But it is worth saying that it is strongly recommended to start taking the drug exactly as prescribed by the doctor. And today I'll tell you why. But first things first.
First, you should talk about the merits of the drug.

Price. The cost ranges from 28 to 60 rubles per pack. Dosages exist for 10 and 25 mg. I took the second option.
Amount in a package. Tablets 50 pieces. Pretty big package. If I drink 2 pieces a day, then it will be enough for 25 days.
Fast action. The effect of taking the remedy is manifested in half an hour. The feeling of anxiety becomes less, the mood begins to improve. It improves both sleep and sleep. By the way, I'm not complaining about this, but still.
High efficiency. Amitriptyline worked quite well for me. So far, satisfied. I've been drinking it for a week now. By the way, the maximum effect of the remedy develops only after 2 weeks approximately. This is indicated in the annotation to the drug.
Now it is worth talking about the shortcomings of the tool.

Bad taste. The tablets taste unpleasant, bitter. But it is quite possible to be patient.

Lots of contraindications. There are a number of diseases in which Amitriptyline is contraindicated. It is also undesirable during pregnancy, as well as when breastfeeding a child. Therefore, you can not ignore the familiarization with the instructions for the drug.
Pronounced side effects. Their list in the annotation looks quite impressive. Personally, I had: confusion, weakening of attention, burning and dry mouth, very strong thirst. Unfortunately, these are the most common side effects. By the way, I found a solution in this situation. I just take pills before bed. But the decrease in sexual desire has become unchanged. And increasing the dosage is also most advisable to do at night. I think it's pretty obvious why. Caution is required. This applies to special instructions in the annotation. They are required reading.
Not compatible with all medications. For example, it enhances the effect of sedatives and hypnotics. In such situations, we are talking about a strong depression of the central nervous system. Not the most useful combination with alcoholic beverages.

The likelihood of withdrawal syndrome. Perhaps with a sharp cessation of taking the drug. The dosage should be reduced gradually.
If we talk about this drug in general, then I can recommend it. But do not forget about caution, as an overdose can have quite bad consequences.

My sad story of acquaintance with antidepressants (hereinafter referred to as AD) began

In short, Amitriptyline was prescribed to me to improve sleep. You can read more about my condition at the link above. There I described Fluoxetine.

Unfortunately, over-the-counter drugs and herbal teas did not help get rid of insomnia. Donormil, Melaksen, etc. - complete nonsense if insomnia is the cause of depression.

From the manufacturer, briefly:

Indications of depression (especially with anxiety, agitation and sleep disturbances, including in childhood, endogenous, involutional, reactive, neurotic, medicinal, with organic brain lesions); as part of complex therapy, it is used for mixed emotional disorders, psychosis in schizophrenia, alcohol withdrawal, behavioral disorders (activity and attention), nocturnal enuresis (with the exception of patients with hypotension of the bladder), bulimia nervosa, chronic pain syndrome (chronic pain in cancer patients, migraine, rheumatic diseases, atypical pain in the face, postherpetic neuralgia, posttraumatic neuropathy, diabetic or other peripheral neuropathy), headache, migraine (prevention), gastric ulcer and duodenal ulcer.

I bought 25 mg tablets, 56 pieces in a blister, produced by Ozone. The cost, to put it mildly, is ridiculous - 20 rubles.

How I was prescribed to drink it:

1. The first two weeks, 0.4 tablets (it is very difficult to share these tiny tablets!) + another blood pressure in the afternoon.

I will write about the second ADE later, when the picture of its reception is formed.

2. For some time (weeks 2-3) at 0.5. Then the doctor allowed me to independently increase the dose to one tablet.

My conclusions:

1. Causes dependence, for it would be desirable to raise and raise. It seems to me that you no longer notice the effect of the pills because the brain requires you to take more poison and blurs the impressions of taking it.
2. In most cases, it causes numbness of the palate, even if you do not split the pill. It is not always possible to swallow it right away, even though it is tiny. An extra second in the mouth - and numbness is guaranteed. Dry throat! Unpleasant feeling: all night long you grunt like a fool because of this stupid dryness.
3. At the beginning of the reception made me a complete vegetable in the afternoon. If earlier it seemed to me that I was a vegetable, now ... I don’t know, a boiled-overcooked vegetable. Fatigue was wild, as if he had not slept at night, fog in his head, an absolute inability to do something, analyze, etc. In this regard, I was prescribed a course of Picamilon, which I will also write about later.
4. And the worst thing... Constipation!!! This is the worst thing that happened to me while taking the pills. Having a sick gastrointestinal tract, I suffered terribly from this dirty trick. There was even a desire to quit Amitriptyline because I did not appear in the toilet for quite a long time. The doctor reduced the dosage to 0.5 + donormil, but in comparison with 1 tablet of 25 mg, this combination loses. so I went back to one tablet at my own risk. You have to sit on laxatives, which is also not cool. Until a solution is found.

I think that there are really a lot of side effects. If you do not have sleep problems caused by depression, if you do not fall asleep at one in the morning, but wake up at four, if you do not fall asleep under Donormil at 23 o'clock, and then do not wake up painfully every half hour, as scheduled, then you do not need to drink Amitriptyline!

Against the background of depression and lack of sleep for several years, I developed shopaholism. What do you do all night when you can't sleep? That's right, spend all the money in online stores. If everything is not so running for you, but simply because of problems at work, they began to sleep worse or after a divorce, the dream went away, let the body recover and everything will be ok, do not poison yourself with this drug.

Added:

Causes severe sweating and tachycardia!

The antidepressant Amitriptyline has been the most popular drug since Soviet times. It is very affordable, especially domestic. In comparison with modern drugs of this group, we can say that it is cheap.

It is prescribed only by a psychiatrist, psychotherapist. I do not advise taking it without an appointment, since this drug has a lot of contraindications and side effects, including those on the heart, stomach, and liver. Previously, about 8 years ago, as prescribed by a doctor, I drank it in small courses, starting with 1/4 tablet at night. Then gradually, I switched to 1/2 tablet, bringing the dose to the whole 25 mg. There is also a children's dose of tablets - 10 mg. It is prescribed not only for depression, but also for sleep disorders, insomnia due to neuroses, and anxiety disorders.

The drug begins to act after about 30 minutes. Drowsiness is felt, calmness comes, anxiety recedes. I strongly recommend that you take these tablets only after meals, or during meals. So they can negatively affect the stomach, cause nausea.

Previously, I tolerated Amitriptyline well, except that I did not feel much dryness in my mouth.

I recently tried to resume taking the drug - I can’t drink a dose of more than 1/4 tablet - I feel very sick.

The pharmacy is sold by prescription. But, if a pharmacy with PND can be sold without a prescription, they just don’t say the dosage, it should be determined only by the doctor, well, you, according to your tolerance.

Indications for the use of the tricyclic antidepressant Amitriptyline are depression, emotional disorders, behavioral disorders, schizophrenic psychosis, neurogenic pain syndrome, neurotic, organic brain damage.

Amitriptyline has an antidepressant, sedative effect by reducing the sensitivity of serotonin, beta-adrenergic receptors. It has an inhibitory effect on the processes in the brain.

The drug soothes pain, promotes scarring of tissues with stomach ulcers, reduces appetite. In the treatment of depression, the effect of the drug does not appear immediately. It takes on average up to 3 weeks for the results of the treatment to appear. Accordingly, the question arises: is it possible to take Amitriptyline with alcohol?

Properties

Tablets, pills are absorbed in the stomach, intestines. In the blood, the drug accumulates at a maximum concentration after 3-8 hours. The half-life is from 10 to 26 hours, metabolites of Amitriptyline are excreted within 18 to 44 hours.

Contraindications

Amitriptyline is contraindicated in the following diseases:

With caution, Amitriptyline is prescribed for epilepsy, high intraocular pressure, heart disease, arrhythmias.

Side effects are noted mainly from the side of the heart, nervous, vascular system, stomach.

When taking the drug observed:

• dizziness, drowsiness, tremor;
• confusion;
• noise in ears;
• nightmares;
• cardiopalmus;
• fainting;
• stomach pain, nausea, loss of appetite.

With an overdose of Amitriptyline, life-threatening conditions develop, convulsions, hallucinations, cardiac arrhythmia occur, psychosis, coma are possible.

On the video description of the drug Amitriptyline:

Interaction with alcohol

Amitriptyline enhances the effect of alcohol. The compatibility of these drugs causes a decrease in blood pressure, has an inhibitory effect on the respiratory center, and depresses the central nervous system.

Ethyl alcohol enhances the side effects of Amitriptyline. With simultaneous use, the risk of visual impairment, the appearance of hallucinations, and disorientation in the surrounding space increases.

Ethanol negatively affects the urinary system, causes significant difficulties with urination, provokes constipation, having a depressing effect on intestinal motility.

Ethanol and the drug negatively affect the liver, exhaust the possibilities of liver enzymes, and create conditions for the accumulation of metabolic products. Moreover, both ethanol and Amitriptyline metabolites are highly active.

So, acetaldehyde is a metabolite of alcohol, several times more toxic than ethyl alcohol itself. The activity of the metabolite of Amitriptyline, the compound nortriptyline, is also high. In addition, nortriptyline is excreted from the body for a longer time (up to 3 days).

The use of alcoholic beverages prolongs the half-life of the drug and its metabolites, which creates the risk of overdose, and the appearance of all the symptoms associated with an overdose in a more pronounced manifestation.

Possible consequences

Alcohol in combination with Amitriptyline:

• increases depression, causes a panic attack, psychosis;
• disrupts liver function, leads to cirrhosis;
• makes it difficult to excrete urine, contributes to kidney failure;
• causes a sharp decrease in blood pressure, a decrease in body temperature, to whom;
• can cause respiratory arrest and death.

Taking 5 g of Amitriptyline causes poisoning, and the lethal dose of the drug in the absence of alcohol in the blood is 12 g. Ethyl alcohol enhances the side effects of the antidepressant, which in an unpredictable way reduces the lethal dose of the drug.

The degree of intensification of the side effects of the drug depends on the condition of the patient's liver, the characteristics of his metabolism, the ability to utilize alcohol, antidepressant and their metabolites.

A person, simply out of ignorance, can exceed a lethal dose if he combines the medicine, even at the prescribed therapeutic dosage, with the use of alcoholic beverages.

Admission rules

Amitriptyline and its metabolites remain in the blood for a long time. It may take several days for the drug to be completely cleared from the body. You can drink alcohol after the last dose of an antidepressant no earlier than 3 days later.

But the tradition of wine drinking, unfortunately, is indestructible. They drink "for the company" even during treatment with antidepressants. Such extreme lovers should be aware of the danger of an overdose of the drug as a result of the intensifying effect of alcohol, take alcoholic beverages in the minimum dose.

You can resume the course of treatment after drinking alcohol no earlier than a day later. The most dangerous consequence of taking alcohol and Amitriptyline can be a severe coma.

And not always the doctors have time to save the victim. And the exit from a coma is accompanied by a deterioration in vision, a violation of cardiac activity, prolonged depression, which is very difficult to treat.

conclusions

Amitriptyline should not be combined with alcohol. Taking even small doses of alcohol-containing drinks can cause severe depression, cancel out the result of several weeks of treatment for depression, stomach ulcers, schizophrenic psychosis.

According to doctors, alcohol is contraindicated both in the treatment of Amitriptyline and in the diseases for which it is prescribed. Drinking alcohol just causes the disease for which antidepressants are prescribed. And it is unacceptable to combine the intake of a depressant, which is alcohol, with the antidepressant Amitriptyline.

Symptoms and dangerous consequences of an overdose of Amitriptyline

As with any medication, the dose may be exceeded during treatment with Amitriptyline, and then such unpleasant moments as the consequences of an overdose, symptoms of poisoning and, accordingly, the fight against them cannot be avoided.

What is Amitriptyline?

The antidepressant Amitriptyline is a "classic" drug for a wide range of ailments and disorders, with a wide range of indications, contraindications, and side effects.

The medicine is produced by pharmacists both in the form of tablets, capsules and dragees, and in the form of solutions for intramuscular injections.

The medicine has a pronounced effect:

This is due to its high antihistamine and anticholinergic activity, and the ease of the possibility of drug poisoning or accidental overdose is also due to this.

How does an overdose occur?

The area of ​​​​use of the drug is quite wide, if we summarize the indications for use, then a medicine is prescribed, mainly in the following cases:

1. depression.
2. Exacerbations of neurological disorders.
3. Behavioral disturbances and inadequacy of reactions.
4. Emotional disorders of mixed nature.
5. Children's enuresis and fears.
6. Nervous bulimia.
7. Chronic migraine.

It is recommended to take the drug, starting with the minimum dose - this is 50 mg per day, then, based on the body's reaction, the dosage is increased, slightly, but regularly - by 100 mg, not exceeding the allowable daily threshold of 300 mg. And at this stage of taking the medicine there is a significant risk of poisoning them.

signs

In the very first hours after taking an excessive amount of a tranquilizer, symptoms such as:

They are quickly replaced by:

At this stage, a person, as a rule, does not attach any importance to his symptoms, the idea that an overdose is possible does not even occur to him. They usually begin to worry only with the appearance of hallucinations, after which the following symptoms can be observed:

• dryness of all mucous membranes in the body;
• urinary retention;
• as opposed to urination - spontaneous relaxation and emptying of the intestine;
• a sharp increase in temperature;
• attacks of tachycardia;
• severe convulsions, in the form of seizures, resembling epilepsy.

After that, the depression of the central nervous system continues, with variable intensity for several hours. This is accompanied by the following symptoms:

• shortness of breath, shortness of breath - similar to asthma attacks;
• a sharp disturbance in the heart rhythm - pronounced fluttering of the ventricles, tachyarrhythmia;
• arterial hypotension.

These features are being replaced by:

Death occurs quickly, with common signs of such ailments as:

• cardiovascular insufficiency;
• asthmatic insufficiency of the respiratory system.

How to cure drug poisoning?

Excessive action of amitriptyline is also dangerous because there is no antidote for the drug. If there is a possibility of an overdose of the drug, then it is necessary to immediately call the doctors, and while they are traveling, provide first aid. It will consist in simple actions:

1. Gastric lavage if the medication was taken less than three hours ago.
2. Reception by the affected sorbent, it is best to double the dosage of activated charcoal.
3. Providing access to fresh air.
4. Conscious person support.

Arriving on a call, doctors, as a rule, immediately hospitalize the victim. In a hospital, treatment will begin with the fact that a person will be connected to cardiac monitoring in order to control:

• frequency and freedom of breathing;
• blood pressure indicators;
• the rhythm of heartbeats.

The following will also need to be monitored:

1. The level of electrolytes, their concentration in the blood of the victim.
2. Acid-alkaline state of the body.

Since no antidote or antidote for tranquilizer poisoning has been invented, and extracorporeal detoxification does not help, the following therapy is carried out:

• In case of interruptions in breathing - artificial ventilation of the lungs, if necessary - incubation of the trachea.
• In case of metabolic acidosis, droppers with solutions of sodium bicarbonate and sodium chloride are installed, if necessary, hyperventilation of the lungs is connected.
• Antiarrhythmic drugs are prescribed.
• In the case of heart failure, solutions of salts and colloids are administered intravenously, sometimes Dopamine infusion is done.
• If necessary, stop convulsions - Valium or Seduxen are prescribed.

Effects

Possible complications after poisoning with Amitriptyline include a number of pathologies. The consequences of an overdose can be divided into two types:

Early, that is, arising, as a rule, in the first year after an accident with a medicine, include:

• acute pneumonia with complications;
• hypocoagulation syndrome with significant bleeding, both internal and external;
• acute renal failure;
• liver disease and dysfunction.

• diseases of the nervous system and brain pathology;
• chronic uncontrolled spontaneous depression;
• organ failure in a chronic form - kidneys, liver, heart.

In the case of treatment with any tranquilizers and antidepressants, it is easier to avoid an overdose than to deal with its consequences. However, drug poisoning does not always occur due to an excessive dose, sometimes it is due to a person’s negligent attitude towards their health and the use of alcohol in conjunction with medications.

Amitriptyline and alcohol

Alcohol and Amitriptyline are incompatible, their simultaneous use can lead to any completely unpredictable consequences, including sudden death.

This is due to the fact that both substances have the same effect on the body:

1. Inhibition of the functions of the central nervous system, their oppression.
2. Increase in blood pressure.
3. Disorientation.
4. Allergic reactions.

And a number of other indicators.

The combination of alcohol and an antidepressant does not just mutually increase their effect at times, it directly strikes at:

• Kidneys, which will manifest itself in the form of blackening of the tongue, nausea, stomatitis.
• The liver, forced to break down both alcohol and a tranquilizer, in response, it will manifest various types of toxicosis.
• A heart that can just stop at any moment.

With alcoholism, as a disease, this antidepressant is not prescribed under any circumstances if the period of sobriety of a person is less than six months. The state of internal organs is also taken into account.

Avoiding Amitriptyline poisoning is simple, just take it correctly - no more than 300 mg per day and do not mix with alcohol.

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For what purpose and when is amitriptyline prescribed?

Quite often, with depression, doctors prescribe amitriptyline to patients, the indications for the use of which are various psycho-emotional disorders. In our country, it was not customary to treat such conditions for a long time, but, according to recent studies, depression is a disease and it requires treatment.

It affects about 20% of the population of all developed countries of the modern world, which puts it on a par with such diseases as cardiovascular diseases and oncology. The main danger is that a person loses the taste for life, he is not interested in anything, no desires arise. And this disrupts the ability to work, affects the work of internal organs, relationships with loved ones. The disease in the initial stages is rarely manifested by disorders of the body systems, and the person does not consider it necessary to visit a specialist. And when it turns, depression is already severe and protracted.

What are the dangers of depression?

With the modern rhythm of life with many problems, difficult situations and instability, depression is increasingly being diagnosed by psychologists and psychiatrists. Usually this disease develops after a severe stressful situation, which was preceded by a long emotional overstrain: a serious illness of a loved one that ended in his death, a wave of layoffs at work and dismissal, long preparation for the exam and failure of one of them, etc.

Depression usually presents with the following symptoms:

• excitement and anxiety;
• constant anxiety;
• oppression;
• increased irritability;
• inability to concentrate;
• loss of interest in the environment.

In order to get rid of the disease, it is necessary to undergo a complex and rather long treatment, including taking various antidepressants, psychosocial therapy and attending special courses that increase emotional stability.

Drug therapy for depression

Treatment with drugs is reduced to taking various drugs that restore the mental and emotional state of a person - antidepressants. They have different mechanisms of action on the nervous system, which determines their belonging to one or another class of medicines. They are divided into the following classes:

More often than others, representatives of the first class of drugs are used in medicine, one of which is Amitriptyline Nycomed. In addition to depression, this drug has other indications for use.

In psychiatry, it is prescribed for a variety of diagnoses, even very severe ones. Amitriptyline Nycomed is effective for the treatment of depression of all types, including neurosis, which led to brain damage. Depression in alcohol dependence, which is reflected by anxiety, sleep disorders, restlessness.

Also, this drug is prescribed for urinary incontinence at night, various phobias, eating disorders (bulimia, anorexia), for the prevention of migraine. It is often included in complex therapy for diseases of the gastrointestinal tract (ulcers, gastritis, gastric bleeding), and can be prescribed for severe pain in cancer patients suffering from rheumatism and neuropathy.

The composition of the drug and its action

The drug is based on the active ingredient amitriptyline hydrochloride. The pharmacological action of Amitriptyline Nycomed is very wide, which leads to a wide range of its appointments. It has such effects as a pronounced sedative, hypnotic and antihistamine. In addition, Amitriptyline Nycomed relieves anxiety well, has an analgesic effect, slightly stimulates the nervous system, gives a feeling of energy and promotes the healing of ulcers on the mucous membranes of the stomach and intestines.

How to use Amitriptyline Nycomed?

The drug is available in two forms - uncoated tablets and intramuscular injections. With psychoemotional disorders of the mild type, Amitriptyline Nycomed is prescribed in tablet form in the most minimal doses. It is taken after meals, without chewing and drinking plenty of liquid.

The specialist prescribes a dose, it depends on the general condition of the patient, his age and the presence of concomitant diseases. On average, the therapeutic effect of the drug occurs after 3 weeks from the day you start taking it.

At the first stages of treatment and in not very severe conditions, the dosage is prescribed as minimal as possible. If there is no improvement, the frequency of administration or dose may increase. In severe emotional disorders or schizophrenia, Amitriptyline Nycomed can be prescribed in the form of injections, followed by a course of tablet treatment.

The duration of admission depends on the diagnosis of the patient and the severity of his illness, and the general therapeutic course is at least one month. The maximum course of taking an antidepressant should not exceed 12 months, because this can lead to severe and irreversible complications, the most severe of which is death.

Like any drug, Amitriptyline Nycomed has contraindications for use. It is not prescribed to patients after myocardial infarction and in the stage of exacerbation of cardiovascular diseases, if the patient is intoxicated, suffers from angle-closure glaucoma, intraventricular obstruction. Do not use Amitriptyline Nycomed in conjunction with sleeping pills, strong psychotropic drugs and analgesics. Do not prescribe this medicine to children and women during breastfeeding.

Amitriptyline - emergency or extreme case

Amitriptyline is a new generation of antidepressants. Producer Poland, Germany. Similar products with the same name are produced by many countries. Released by prescription. It has a pronounced sedative effect. It is prescribed for severe nervous disorders, irritability, aggressiveness, panic attacks, migraines. In special cases, it is prescribed for menopause with severe CNS disorders. The therapeutic effect develops 2 weeks after the start of treatment.

Release form

Produced in the form of dragees or tablets, solution for injection. The injections are administered intramuscularly. In this form, it is used in therapy within the walls of the hospital. At home, dragee is more often used.

The tablets are round yellow. The package contains 50 pieces. The active ingredient is amitriptyline hydrochloride. As additional components are used:

The shell of the tablets is resistant to the acidic environment of the digestive tract. Efficiency is not lost.

In the form of a solution for injection, it is available in transparent ampoules of 10 pieces per pack.

Store at a temperature not exceeding 25 degrees Celsius. Shelf life 3 years.

Indications for use

Climax negatively affects the entire body. The central nervous system is under special stress. In a mild form, a woman feels irritability, mood swings, feels a sense of self-pity. Tearfulness, anger, and other unpleasant states are observed. With a strong load on the CNR, more dangerous conditions can be observed: aggression, clouding of consciousness, panic attacks, fear, thoughts of death, and so on. Amitriptyline is prescribed by a doctor after a conversation with a woman, an examination. It is highly undesirable to start treatment on your own. The drug is very strong, if used improperly, causes severe side effects.

The indication for use is:

• persistent depression;
• neurosis;
• significant behavioral disorder;
• phobias;
• emotional disorders;
• anorexia;
• chronic pain syndrome on a nervous basis.

Prescribed to prevent migraine if there have been problems in the past in this part. A direct indication for treatment with Amitriptyline is a confirmed diagnosis:

Mild sleep disorders, mood swings Amitriptyline is not treated. To do this, use lighter means.

Contraindication

Amitriptyline is the strongest antidepressant that affects the functioning of the central nervous system. In this regard, there are a number of contraindications:

• myocardial infarction;
• pronounced drops in blood pressure;
• diseases of the liver, kidneys;
• diseases of the gastrointestinal tract;
• heart failure;
• atony of the bladder;
• individual intolerance to the components;
• parallel therapy with MAO inhibitors.

Caution should be given to women with:

• bronchial asthma;
• manic-depressive psychosis;
• with heart problems;
• schizophrenia;
• glaucoma;
• alcoholism;
• epilepsy;
• in violation of hematopoiesis.

In case of problems with the kidneys and liver, the doctor may decide on the advisability of treatment, but with a correction of the daily dose. In the future, the patient's condition is constantly monitored.

Terms of Use

Dragee is swallowed whole during meals or after a meal. Wash down with a small amount of liquid. The optimal dose per day is 200 mg. Start taking the drug with 50-75 mg per day. Increase every day by 25 mg. The maximum dose is taken at bedtime. Reception is carried out 3-4 times a day. In severe depression, increase to 300 mg. The therapy is carried out under the supervision of doctors.

After achieving a stable therapeutic effect after 4 weeks, the dose is gradually reduced every day. If signs of disorder appear again, return to the previous dosage. In the absence of the desired effect for about 1 month, the therapy is canceled due to the lack of a proper result.

Elderly women after 65 years of age are prescribed pills in doses of 25, 50, 100 mg per day. Divided into several receptions or drink at night for 1 time. To prevent migraine, severe headache, take 100 mg per day.

Intramuscularly injected 10-30 mg slowly. The injection sites must be changed. Daily dose 150 mg. After 3 weeks of injections, you should switch to a dragee. Injections are administered during therapy within the walls of the hospital.

Concurrent use with drugs

Amitriptyline enhances the side effects of drugs:

• anticonvulsants;
• sedatives;
• neuroleptics;
• sleeping pills;
• means of anesthesia;
• other antidepressants;
• analgesics;
• alcohol.

Concurrent use with birth control pills enhances the activity of Amitriptyline. Its combined use with MAO inhibitors leads to death. The interval between treatments with these drugs should be at least 2 weeks.

Unwanted Effects

Causes a lot of side effects. Some of them do not require interruption of treatment, go away on their own after a few days. In some cases, the dose is adjusted. The situation is considered under control and quite normal.

• increased intracranial pressure;
• dry mouth;
• bowel problems;
• blurred vision;
• temperature rise;
• problems with urination.

A large list of side effects occurs from the side of the central nervous system, digestive, cardiovascular, endocrine. There is an allergic reaction on the skin. With prolonged therapy, there is an increase in body weight, increased sweating.

Side effects appear after the drug is discontinued. Especially if the doses were high.

special instructions

Therapy with Amitriptyline should be carried out according to the doctor's prescription, under his supervision. Periodically, it is necessary to undergo an examination, take tests. It is strictly forbidden to take alcohol during therapy. It is not recommended to drive a car, perform work that requires high accuracy, fast response. After the age of 65 years, the daily dose should not exceed 100 mg. At high doses, convulsive seizures are possible.

Overdose

Toxic symptoms are observed a few hours after taking the next dose.

• pupil dilation;
• apathy;
• loss of consciousness;
• decrease in body temperature;
• drowsiness;
• hallucinations;
• pressure reduction;
• disruption of the heart;
• convulsions;
• coma.

To eliminate the symptoms, it is necessary to perform gastric lavage, provide symptomatic treatment.

Effect on the body

Amitriptyline improves pathologically low mood, eliminates headaches, removes panic attacks, neurasthenia, neuroses, and normalizes sleep. A significant improvement is observed after 3 weeks of treatment. The analgesic effect is observed almost immediately. After internal administration of the tablet, a high concentration in the blood appears after 4 hours. The half-life is 25 hours. It is excreted mainly in the urine. The therapeutic effect lasts for a long time. A second course is prescribed according to indications not earlier than 1 month after the end of the previous one.

The cost of the drug

Amitriptyline is an affordable drug. You can buy it at any pharmacy with a prescription from a doctor. The cost depends on the location of the pharmacy, manufacturers.

• Tablets 25 mg, 50 pcs. - 26.50 rubles;
• Tablets 10 mg, 50 pcs. - 27.00 rubles;
• Tablets 20 mg, 50 pcs. - 46 rubles;
• Ampoules, 2 ml, 10 pcs. - 46 rubles.

Amitriptyline is produced by Denmark, Russia, Croatia, Poland, Germany, Czech Republic.

Analogues

Among similar products with an identical active ingredient, we can distinguish:

The question of replacing Amitriptyline with another similar drug should be discussed with the doctor.

Amitriptyline is produced in many countries. The buyer himself makes a choice in favor of one or the other. The price differs insignificantly. The main difference between the drug in manufacturing technology. The final choice is up to the buyer.

Reviews of women taking Amitriptyline

“They prescribed a drug for deep depression. I took it according to the instructions. At first there was a state of deep hibernation. Don't care at all. I just wanted to sleep. Apathy was present for a week, then hallucinations began to appear in broad daylight. Stopped taking it out of fear. Didn't go to the doctor. I did not notice any side effects after that, it even got better right away. My depression also disappeared, probably from fear. In general, the drug is terrible!

“Terrible side effects are not for me. I took 170 mg per day. Of the undesirable effects of dry mouth. Sleep didn't get better. I still woke up at 4 in the morning, I could not fall asleep. As a sleeping pill it does not work at all. I didn't have depression."

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She suffered from a terrible migraine. They prescribed me this drug. Initially, I was alarmed by the side effects, and what applies to antidepressants. Then the doctor explained that the migraine was due to the severe stiffness of the body. Amitriptyline relieves stress, allows the body to relax. I noticed results almost immediately. The migraine stopped tormenting after a week of taking it. She was still treated for 2 weeks. Within 1 year, the headache bothered slightly. The drug helps. Of the side effects, I had an unpleasant aftertaste in my mouth, my eyesight worsened during the treatment, then it recovered. Dreams were unusual, not always good. After cancellation, no unpleasant symptoms!

There was a terrible depression, I did not want to live. This drug was prescribed. I vaguely remember my first impressions. You just turn into a vegetable. Nothing to worry about, nothing to care about. Slept day, night, could not sleep off. A week later she began to revive. There was a mood, an interest in life. Slowly everything got better. I would like to note that the drug is very strong. It is better to fight ordinary depression by other means. Besides, you can't get carried away. Get used to it like a drug!

She suffered from chronic joint pain. The neurologist explained that my pain was imaginary, from nerves. Prescribed this drug. I took it according to the instructions. Frightening side effects. Pain relief almost immediately. Gradually, she stopped feeling pain. After 2 weeks I didn't feel it at all. Completed the course. Everything became good. Chronic pain that tormented me for 2 years disappeared in 1.5 months!

Amitriptyline

Release form

Sale: prescription

Shelf life: 24 months.

Sale: prescription

Storage: 15-25C (room temperature)

Expiration date: 36 months.

Instructions for amitriptyline

Amitriptyline is a classic tricyclic antidepressant. It inhibits the reuptake of norepinephrine and serotonin by presynaptic neurons, which leads to an increase in the concentration of these mediators and the development of an antidepressant effect. With regular use, it suppresses the activity of cerebral beta-adrenergic receptors and serotonin receptors, normalizes the propagation of nerve impulses through these receptors, eliminates the imbalance of these systems caused by depression, exhibits an anxiolytic (anxiety-eliminating) effect, reduces agitation (emotional overexcitation) and manifestations of depression. It has a mild analgesic effect, which, according to scientists, is due to fluctuations in the level of monoamines (primarily the neurotransmitter serotonin) in the central nervous system and the effect on the body's own (internal) opiatergic systems. The pronounced ability to bind to m-cholinergic receptors causes a powerful anticholinergic effect of Amitriptyline, and its ability to interact with histamine H1 receptors and block alpha-adrenergic receptors is a sedative effect. It has an anti-ulcer effect, reduces the severity of pain in stomach and duodenal ulcers, provides the fastest scarring of the ulcer. The anticholinergic activity of Amitriptyline mentioned above, which increases the elasticity of the bladder walls and their ability to stretch, makes it effective in the treatment of enuresis. This property of the drug is reinforced by direct beta-adrenergic stimulation and blocking the uptake of the mediator serotonin by central neuronal synapses. Amitriptyline reduces bulimia nervosa with or without comorbid depression. The antidepressant effect of the drug begins to clearly manifest itself at 2-3 weeks from the start of drug therapy.

Bioavailability of Amitriptyline is about 50%, half-life. Elimination from the body is carried out with urine. The drug is available in tablet and ampouled form. Begin pharmacotherapy with a dose of mg, the optimal time of admission is before bedtime. Gradually, during the week, the dose is increased by 3-4 times. In the absence of improvement in the second week, the daily dose is increased to 300 mg. Elimination of depressive manifestations is not a reason for refusing treatment: in this case, the dose is reduced to daily mg and pharmacotherapy is continued for at least another three months. In elderly people with a mild course of depression, the dose of the drug is set in the range from 30 to 100 mg per day, and when positive results are achieved, they switch to a maintenance daily dose of vmg. In the course of treatment, it is necessary to avoid situations that require a sharp rise from a sitting or lying position. It is not recommended to abruptly interrupt treatment: in this case, a withdrawal syndrome may develop. It is necessary to take the necessary precautions when using Amitriptyline in patients suffering from epilepsy, because. the drug in a daily dose of more than 150 mg reduces the convulsive threshold. When planning treatment, the possibility of suicide attempts in patients suffering from severe depression should be kept in mind. The combined use of Amitriptyline and electroconvulsive therapy is possible only under the condition of constant medical monitoring. In patients with a burdened history and the elderly, taking the drug can lead to the occurrence of pharmacological psychoses (after the cessation of drug therapy, such phenomena quickly disappear). Prolonged use of Amitriptyline may lead to the development of caries. The drug is not compatible with alcohol.

Reviews of doctors about amitriptyline

Amitriptyline belongs to the tricyclic antidepressants, the oldest antidepressant. Subjectively not suitable for all patients. Yes, it removes well the affect of melancholy, anxiety for 2-3 weeks of constant use. The best effect at stationary dosages and in a hospital. Well relieves anxiety, effective in the treatment of panic attacks.

Subjectively, some patients note drowsiness, according to patients, "stomps, sausages." Others take large doses and experience no side effects. It must be remembered that after 2 weeks of admission, some patients, more often men, may experience urinary retention.

Inexpensive effective antidepressant.

A good antidepressant with sufficient effect, time-tested, is available. It helps well in neurological practice in the treatment of chronic pain syndrome, mainly in peripheral neuropathies of various origins, postherpetic neuralgia, migraine.

There are side effects, mainly at the beginning of taking the drug, in the form of drowsiness, dizziness, dry mouth, changes in taste, sometimes feelings of anxiety, anxiety, as a result of which it is necessary to titrate the dosage at the beginning and at the end of taking the drug.

The drug of choice for patients with limited finances, but you have to put up with side effects.

Affordable, inexpensive antidepressant, on which sufficient experience has been collected. It has the widest spectrum of receptor activity.

Causes quite pronounced side effects: dry mouth, urinary retention, sedation. Not everyone is suitable for outpatient treatment. Not recommended for first line treatment of depression, as SSRIs don't work well after that.

An excellent analgesic for headaches (psychosomatic). And the antidepressant is just wonderful.

Disappeared from pharmacies at a dosage of 10 mg. Urinary retention is possible.

Far from golden, but certainly the standard of antidepressant therapy. It combines well with other drugs, suitable as an adjunct to therapy before the development of the effect of SSRIs and as a symptomatic agent.

At the present stage, the appointment of amitriptyline, in my opinion, is preferable in a specialized department, moreover, by injection - for the rapid relief of severe neurotic depression. Best of all - in / in the drip for 1 week, followed by the selection of a serotonergic antidepressant.

All known side effects, the most important of which are cystitis, prolactinemia, QT interval widening, weight gain.

Until now, almost the only drug that allows you to achieve an almost "instant" antidepressant effect.

The drug from the first generation of antidepressants belongs to the group of tricyclic antidepressants. Indispensable for a major depressive episode and anxiety-depressive symptoms. Minimum price.

Often side effects in the form of dryness, accommodation spasm, sphincter spasm and sexual dysfunction.

The drug is affordable and effective.

There are side effects that reduce the quality of life for people taking this drug. These include lethargy and the inability to engage in mental work, drive a car, as the reaction rate decreases sharply. In men suffering from prostatic hyperplasia, it can cause urinary retention.

For a long time of use in neurological practice, as an adjuvant for the treatment of dysfunctional back pain, Amitriptyline has shown itself to be quite effective when taken once daily for a short period.

Most side effects occur when the dosage of the drug is incorrectly selected and patients do not comply with the regimen.

Amitriptyline is very often prescribed in the wrong doses, for the wrong duration, and in the wrong combinations. The use of amitriptyline requires experience and skill. It would be worth forbidding to prescribe it to non-psychiatrists. I stopped prescribing it myself a long time ago. I think this is the prerogative of psychiatrists.

In outpatient practice, it is extremely difficult for working people to use it due to numerous side effects.

An interesting effect when combined with other drugs, but the main thing is its effectiveness, and, of course, price and quality.

Of the side effects, the main disadvantage is dry mouth, increased appetite and drowsiness, sometimes disorientation, muscle rigidity, in particular the bladder, sometimes with an overdose of vomiting, arrhythmia, arterial hypotension, heart failure, respiratory depression. But if taken correctly and carefully, then disadvantages can be avoided.

Amitriptyline is the gold standard for tricyclic antidepressants.

The drug is old, rather well studied, used for various neurological and mental disorders, as well as in the treatment of persistent pain syndromes in combination with analgesics (for example, in cancer patients).

Many side effects, not designed for long-term use.

Main advantage: efficiency at low cost. These two facts allow amitriptyline to remain in medical practice, despite frequent side effects. "Cheap and cheerful."

"Good old" antidepressant. One of the first. Well studied. Until now, it “does its job” well in a narrow range of clinical situations: 1) severe endogenous depression with severe anxiety, agitation, suicidal tendencies; 2) post-psychotic (post-schizophrenic) depressions with the threat of exacerbation, failure of remission; 3) therapy of anxious depressions in the structure of chronic endogenous psychoses, especially in those cases when insurance against exacerbation of the course of the endogenous process is needed; 4) depressive phases in the structure of bipolar affective disorder with the threat of phase inversion (usually in the absence of proper normothymic therapy).

It is well known - cardiotoxic, extremely pronounced anticholinergic side effects - dry mouth, nausea, constipation, etc. Strong sedation, sexual dysfunction, metabolic syndrome.

In the presence of new generation antidepressants, these are not “cons”, these are the features of tricyclic antidepressants, just like with MAO inhibitors, everything was even an order of magnitude more complicated.

An excellent choice for patients in a difficult financial situation. It can be used for sleep disorders, anxiety depression, persistent hypochondria in various combinations, depressive symptoms within illnesses with severe psychotic symptoms. Speed ​​is good.

Side effects are terrible dryness, dizziness, drowsiness that disappears from the beginning, tachycardia, problems with urinary retention in both men and women. Be careful with the elderly.

A powerful drug, in which side effects are often ahead of the curative ones.

Amitriptyline is a tricyclic antidepressant that I prescribe to my patients with endogenous depression of varying severity. The drug has a good antidepressant effect, but sometimes it takes a long time to wait for the effect. Alas, this drug is not without side effects, which often force patients to refuse this drug.

Amitriptyline is a drug from the group of antidepressants prescribed for depression, psychosis, emotional and phobic disorders. It has a pronounced sedative and thymoanaleptic effect - the treatment leads to the activation of the psyche and an improvement in mood. Refers to the antidepressants of the "old" generation.

Despite the rapid therapeutic effect, the opinions of doctors about this remedy in the first line of treatment are divided. Consider how amitriptyline works and is used, what is the danger of uncontrolled intake and overdose of the drug.

Description of instructions for use of amitriptyline

Amitriptyline is a drug from the group of tricyclic antidepressants. In addition to the main effects, it has an analgesic effect, helps in the treatment of bedwetting.

Amitriptyline is produced by several manufacturers - domestic Veropharm, ALSI Pharma, as well as foreign ones - Grindex, Nycomed, under different trade names:

• "Amizol";
• "Amirol";
• "Saroten retard";
• "Triptizol";
• "Elivel".

Amitriptyline belongs to the pharmacological group of antidepressants. Its gross formula is C20H23N. International non-proprietary name (INN) - amitriptyline.

Forms of release and composition

Amitriptyline is available in two dosage forms - tablets and solution.

1. Tablets of 10 and 25 mg for internal use. Packed in contour packs of 50 and 100 pieces.
2. Solution 10 mg/ml, 2 ml ampoules for intravenous and intramuscular administration. There are 10 pieces in a package.

The tablets contain 10 or 25 mg of the active substance - amitriptyline hydrochloride. Additional (inactive) substances - microcrystalline cellulose, talc, lactose monohydrate, silicon dioxide, magnesium stearate, pregelatinized starch.

The composition of the drug "Amitriptyline" in the form of a solution includes 10 mg of the active substance and additionally - hydrochloric (hydrochloric) acid, benzethonium and sodium chloride, dextrose monohydrate, water for infusion.

pharmachologic effect

The drug belongs to strong antidepressants. The mechanism of action of amitriptyline on the body is an increase in the concentration of norepinephrine in the synapses and serotonin in the nervous system (their reabsorption decreases). With long-term treatment, the functional activity of beta-2 adrenergic and serotonin receptors in the brain decreases. It has a pronounced anticholinergic effect (central and peripheral).

How does amitriptyline work for depression? - improves mood, reduces psychomotor agitation, anxiety, normalizes sleep. The antidepressant effect of the drug appears 2-3 weeks after the start of the intake.

In addition to the pronounced antidepressant effect, the drug has a number of other actions.

1. Antiulcer, associated with blocking histamine receptors in the digestive organs.
2. Decreased appetite.
3. An increase in the ability of the bladder to stretch and an increase in the tone of its sphincter, based on a decrease in the activity of serotonin and acetylcholine receptors.
4. If general anesthesia is planned, then it is necessary to warn the doctor about taking this medication, as it lowers blood pressure and body temperature.
5. Eliminates pain syndrome. When does amitriptyline start to help with pain? - according to patients, already for 2-3 days of treatment.
6. Eliminates nighttime urinary incontinence.

Indications for use

The list of indications is extensive, but the main reason for prescribing amitriptyline is depressive states of various origins.

What helps amitriptyline?

1. Depression - involutional, endogenous, neurotic, reactive, drug, on the background of alcohol withdrawal, organic brain damage. Especially flowing with anxiety, sleep disorders.
2. Emotional disorders of mixed nature. Amitriptyline may be prescribed for panic attacks.
3. Psychosis on the background of schizophrenia, alcohol withdrawal.
4. Behavioral disorders (changes in attention and activity).
5. Nocturnal enuresis.
6. Chronic pain syndrome - oncological, rheumatic diseases, postherpetic neuralgia, post-traumatic pain.
7. Nervous bulimia.
8. Prevention of migraine.
9. Ulcerative lesions of the digestive system.

Indications for the use of tablets and Amitriptyline solution are similar.

Dosage and administration

The therapeutic dose and duration of treatment are prescribed privately. How long can you take amitriptyline? - a course of no more than 8 months.

The use of tablets

Should I take amitriptyline before or after meals? Tablets are taken after meals, without chewing, to reduce the irritating effect on the stomach.

The instructions for use of Amitriptyline tablets indicate the following recommended dosages.

1. Treatment of depressive states. The initial dose is 25–50 mg at night. Then increase gradually, within 5 days to 200 mg per day, divided into 3 doses. If the therapeutic effect does not occur within 2 weeks, the daily dose is increased to the maximum possible - 300 mg.
2. Treatment of headaches, migraine, chronic pain syndrome. The therapeutic dose is 12.5-100 mg per day, the average is 25 mg. How to take amitriptyline for headaches and other types of pain? - once, at night.
3. The dosage of Amitriptyline tablets in other conditions is selected individually.

How to take amitriptyline at night for insomnia? If there is a sleep disturbance against the background of depression, then this does not require a change in the standard scheme, the drug is taken as described above.

Solution application

The solution is administered intravenously or intramuscularly, slowly. The daily dose is 20-40 mg, divided into 4 injections. Gradually switch to the oral form, that is, to tablets.

Use during pregnancy and lactation

The drug belongs to the C category of action on the fetus according to the FDA classification (negative effects were found in animal studies). Therefore, the appointment of amitriptyline during pregnancy is highly undesirable. It is used only if the intended benefit to the mother outweighs the risk to the fetus.

When the drug is prescribed during lactation, breastfeeding should be stopped for the entire course of treatment.

Application in childhood

Amitriptyline is prescribed for children to treat bedwetting:

• tablets - from the age of six;
• solution - from twelve.

It is rarely prescribed in childhood for the treatment of depressive states. In this case, the dose, frequency rate and duration of treatment are selected individually.

children's enuresis

How is amitriptyline taken in children with depression? - dosage as follows:

• at the age of 6 to 12 years - 10-30 mg per day or 1-5 mg / kg;
• adolescents from 12 years old - up to 100 mg.

For nocturnal enuresis:

• children from 6 to 10 years old, 10-20 mg per day at night;
• adolescents 11-16 years old - up to 50 mg per day.

Use in the elderly

In old age, it is mainly prescribed for mild depressive disorders, bulimia nervosa, mixed emotional disorders, psychosis on the background of schizophrenia and alcohol dependence.

How to take amitriptyline in the elderly? At a dose of 25-100 mg at night, once. After achieving a therapeutic effect, reduce the dose to 10-50 mg per day.

Side effects and complications

Side effects of amitriptyline develop very often and can be so pronounced that they exceed the therapeutic effect of the treatment. In this regard, the decision on the appointment is always made carefully, and patients and their relatives should evaluate their condition during treatment.

dilated pupils

Side effects associated with anticholinergic action:

• blurred vision, dilated pupils, paralysis of accommodation, increased intraocular pressure in people with a narrow angle of the anterior chamber of the eye;
• dry mouth;
• confusion;
• constipation, paralytic ileus;
• difficulty urinating.

Side effects from the central nervous system:

For the cardiovascular system:

• tachycardia;
• arrhythmia;
• orthostatic hypotension;
• ECG changes in patients who do not have heart disease;
• jumps in blood pressure;
• violation of intraventricular conduction.

From the gastrointestinal tract:

From the endocrine system:

• swelling of the testicles;
• an increase in the mammary glands in men;
• decrease or increase in libido;
• problems with potency;
• increase or decrease in blood sugar;
• decreased production of vasopressin.

Allergic reactions:

• skin rash, urticaria;
• angioedema (Quincke);
• photosensitivity.

Other side effects:

• noise in ears;
• hair loss;
• edema;
• increase in body temperature;
• enlarged lymph nodes;
• urinary retention.

special instructions

Take precautions seriously and balance the risk of adverse reactions with the benefits of treatment.

Based on possible reactions, the following categories of people should use this medicine with extreme caution:

• suffering from alcoholism;
• children and adolescents under 14 years of age;
• elderly patients;
• with diseases such as schizophrenia, bronchial asthma, bipolar disorder, epilepsy, inhibition of bone marrow hematopoiesis, heart and vascular diseases, intraocular hypertension, stroke, decreased motor function of the stomach and intestines, liver, kidney failure, thyrotoxicosis, prostate enlargement, urinary retention, bladder hypotension.

Contraindications

All of the following contraindications to the use of amitriptyline are absolute! Therefore, when prescribing a drug, the doctor always studies the patient's history.

When is amitriptyline contraindicated? - under the following conditions:

• hypersensitivity to the drug;
• acute and subacute periods of myocardial infarction;
• in combination with MAO inhibitors, as well as 2 weeks before the start of their intake;
• alcohol intoxication;
• poisoning with sleeping pills, psychoactive, analgesic drugs;
• angle-closure glaucoma;
• violation of atrioventricular and intraventricular conduction of a severe degree;
• lactation period;
• galactose intolerance;
• glucose-galactose malabsorption;
• lactase deficiency;
• tablets are contraindicated in children under 6 years of age, and the solution is up to 12;
• pregnancy, especially in the first trimester.

Storage conditions and shelf life

"Amitriptyline" in tablets and solution should be stored in a dry, dark place, at a temperature not exceeding 25 ° C. Children and people with mental illness, alcoholism and drug addiction should not have access to medicine!

The shelf life of the drug is 3 years.

Amitriptyline and alcohol

Mixing this medicine with alcohol is strictly prohibited! In some cases, amitriptyline is prescribed for the relief of withdrawal symptoms in alcoholics after hard drinking, but only strictly in a hospital.

Why is the combination of amitriptyline with alcohol dangerous?

1. A person from their joint reception falls asleep soundly - the hypnotic effect of the drug is enhanced several times. Exceeding the dose of amitriptyline in this case is the cause of a violation of the respiratory system, which can lead to cardiac arrest.
2. The effect of alcohol intensifies - the effect of drinking a glass of beer can be like that of the same amount of vodka.
3. A dangerous combination is used by many people to enhance the hypnotic effect of amitriptyline (deliberate but slight overdose). Very quickly develops addiction, similar to a drug. A person ceases to think sensibly, assess the danger of the situation, accurately dose the drug, so every pill taken can be fatal. With severe poisoning with amitriptyline with alcohol, the chances of survival tend to be zero.
4. The consequence of the regular combination of amitriptyline with a small amount of alcohol is an irreversible change in the human psyche - intelligence decreases, memory deteriorates, household and professional skills are lost. All organs and systems suffer, especially the liver, kidneys, heart, blood vessels, brain. All side effects of amitriptyline are fully manifested.
5. Between taking alcohol and amitriptyline should withstand the time. You can't take it with a hangover. Even if consumed a day after taking the tablets, symptoms of poisoning may appear - nausea, vomiting, decreased visual acuity. When can I take amitriptyline after alcohol? - not earlier than in two days!

It is impossible to combine amitriptyline and alcohol under any circumstances, as it is deadly!

Dependence on amitriptyline

The drug does not belong to narcotic drugs, since it does not have an intoxicating or intoxicating effect, it does not cause classical physiological addiction, like opiates. Dependence on amitriptyline is only psychological and has nothing to do with physical craving for the drug. To understand the nature of addiction, you need to know the principle of the drug - natural neurotransmitters do not undergo decay in the body at a normal rate, so they remain unchanged for a long time. The effect of taking amitriptyline is achieved by maintaining a constant concentration of serotonin and other neurotransmitters at a high level.

Is amitriptyline addictive? Like all antidepressants, it is able to form a certain dependence - with a sharp withdrawal, the symptoms return again. Only in this sense can amitriptyline be considered as a drug, since while the drug is taken, the person is well, and when the course is completed, the state returns. It happens that patients switch from antidepressants to real drugs. Therefore, in order to exclude possible harm from amitriptyline, its reception is canceled gradually, within a month.

withdrawal syndrome

With a sharp refusal of the drug, especially if it was taken in high doses, the development of amitriptyline withdrawal syndrome is possible. What are the symptoms of this?

• nausea;
• vomit;
• headache;
• diarrhea;
• sleep disorders;
• malaise;
• nightmares.

Even with a gradual refusal, motor restlessness, irritability, sleep disturbances, and difficult dreams develop.

How long does amitriptyline withdrawal last? - the condition is observed during the time until the entire drug is excreted from the body, that is, 8-14 days. Further manifestations are already more psychological in nature.

The scheme for reducing the intake of amitriptyline is a gradual decrease in the therapeutic dose over a month, starting from ¼ and until completely canceled.

Overdose

An overdose of a drug is not uncommon, therefore, in most cases, the drug is prescribed only to inpatients, under the supervision of a physician.

Amitriptyline poisoning according to ICD-10 class

sified - T43.

Reasons for an overdose

Exceeding the dose for a single dose of the drug most often occurs in the following cases:

• non-compliance with the dose prescribed by the doctor (deliberate or accidental excess);
• self-administration of the drug without a doctor's prescription;
• combination of the drug in a therapeutic dose with alcoholic beverages.

Overdose symptoms

Depending on the amount of amitriptyline taken, 3 degrees of overdose are distinguished - mild, moderate and severe, which, without resuscitation, ends in death in 100% of cases.

Children are most sensitive to acute overdose, up to death.

A mild overdose of amitriptyline is expressed by the following symptoms:

• dry mouth;
• constipation;
• lack of urination;
• dyspepsia.

Moderate to severe overdose symptoms are always serious and require immediate medical attention.

1. From the side of the central nervous system - increased drowsiness, hallucinations, causeless anxiety, epileptic seizures, increased reflexes, impaired pronunciation, muscle rigidity, confusion, loss of orientation in space, impaired concentration, psychomotor agitation, ataxia, stupor, coma.
2. From the side of the heart and blood vessels - arrhythmia, tachycardia, impaired intracardiac conduction, heart failure, a sharp decrease in blood pressure, shock, cardiac arrest (rarely).
3. Other manifestations are a decrease in the amount of urine, up to its complete absence, hyperthermia, increased sweating, vomiting, shortness of breath, respiratory depression, cyanosis, kidney and liver dysfunction.
4. At the terminal stages, blood pressure drops, pupils do not react to light, reflexes fade, liver and heart failure and respiratory arrest develop.

The lethal dose is 1.5 grams of amitriptyline taken at a time. However, smaller amounts are enough for children.

Treatment of poisoning

At the first signs of an overdose, the following pre-medical measures should be taken.

1. Call an ambulance.
2. Give the patient a liter of water to drink and provoke him to vomit. Repeat this procedure until clean wash water appears.
3. Take enterosorbents to reduce the absorption of the drug into the blood - "Enterosgel", activated carbon, "Atoxil", "Polysorb MP" and others.
4. If a person has lost consciousness, he must be turned to the side.

Treatment of poisoning with amitriptyline is carried out in intensive care and includes the following therapeutic measures.

1. Emergency gastric lavage.
2. The introduction of saline solutions to maintain the level of blood pressure, correction of acidosis, water and electrolyte balance.
3. Taking cholinesterase inhibitors to eliminate anticholinergic manifestations.
4. The introduction of glucocorticoids with a sharp drop in blood pressure.
5. Prescribing antiarrhythmic drugs for the heart.
6. 24/7 patient monitoring with blood pressure and heart rate monitoring.
7. In severe cases - resuscitation, anticonvulsant measures, blood transfusion.

Hemodialysis and forced diuresis have not proven effective in amitriptyline overdose.

There is no specific antidote for amitriptyline poisoning.

Consequences of poisoning

A severe overdose is fatal, even if medical care was provided on time. The cause of death is cardiac arrest, respiratory arrest, severe arrhythmia.

The consequences of an overdose of amitriptyline remain, even if the person managed to survive:

• mental changes, severe depression;
• chronic renal and hepatic insufficiency;
• violation of the heart rhythm.

Residual effects are observed throughout life and require constant drug therapy.

Analogues

The structural analogue of amitriptyline is the imported drug Saroten retard, which is manufactured by H. LUNDBECK A/S (Denmark).

What else can replace amitriptyline? Group analogues are "Anafranil", "Doxepin", "Melipramine", "Novo-Triptin" - the drugs have the same effect, but differ in composition. These drugs are modern analogues of amitriptyline without the presence of side effects characteristic of taking an antidepressant.

Interaction with other drugs

Before you start treatment with amitriptyline, you need to tell your doctor about all the medicines that you take constantly.

1. It cannot be combined with MAO inhibitors.
2. Amitriptyline enhances the inhibitory effect on the brain of sedatives, hypnotics, analgesics, drugs for anesthesia, antipsychotics and ethanol-containing drugs.
3. Reduces the effectiveness of anticonvulsants.
4. May be given in combination with sleeping pills (for example, Sonapax is taken with amitriptyline). But in this combination, it increases the anticholinergic activity of Sonapax - that is, it reduces the ability of brain cells to transmit nerve signals.
5. In combination with other antidepressants, the effects of both drugs are enhanced.
6. When combined with antipsychotics and anticholinergic drugs, body temperature may increase and paralytic ileus may develop.
7. Amitriptyline enhances the hypertensive effects of catecholamines and adrenostimulants, increasing the risk of tachycardia, cardiac arrhythmias, and severe hypertension.
8. May reduce the antihypertensive effect of guanethidine and related drugs.
9. In combination with coumarin or indandione derivatives, the anticoagulant activity of the latter may increase.
10. In combination with cimetidine, the concentration of amitriptyline in the blood plasma increases, which increases the likelihood of developing toxic effects.
11. Inducers of microsomal liver enzymes (carbamazepine and other barbiturates) reduce the concentration of amitriptyline.
12. Quinidine reduces the metabolism of amitriptyline.
13. Estrogen-containing hormonal agents increase the bioavailability of amitriptyline.
14. In combination with disulfiram and acetaldehyde dehydrogenase inhibitors, delirium may develop.
15. Amitriptyline is able to increase depression, which appeared on the background of taking glucocorticoids.
16. In combination with drugs for the treatment of thyrotoxicosis, the risk of developing agranulocytosis increases.
17. Combinations with nootropics lead to a weakening of the effect of these drugs and increase the likelihood of side effects.
18. With caution, you need to combine with digitalis preparations and baclofen.
19. Good compatibility of amitriptyline with antibiotics, antiviral drugs (for example, Acyclovir). Can be combined as prescribed by a doctor.

FAQ

Niche we will answer popular questions based on search queries that relate to the features of the use of amitriptyline and its combination with other drugs that are not listed in the official instructions.

1. Is amitriptyline available by prescription or not? Terms of sale in pharmacies - only by prescription.
2. What is the compatibility of amitriptyline and Donormil, can these drugs be combined? This combination is practiced by doctors - amitriptyline will enhance the effect of Donormil. But drugs are taken at different times of the day and strictly in a hospital under the supervision of a doctor.
3. What is the compatibility of amitriptyline and Phenibut? Since "Fenibut" refers to nootropics, in combination with amitriptyline, the therapeutic effect of both drugs is reduced, and the likelihood of side effects increases. This combination should be discussed with your doctor.
4. Is amitriptyline compatible with Corvalol? The drugs do not have antagonism, but Corvalol contains phenobarbital, which can enhance the effect of amitriptyline.
5. Is carbamazepine (Zeptol, Carbalepsin retard, Tegretol, Finlepsin) compatible with amitriptyline? The drugs can be administered together, but it should be remembered that there may be an increase in the inhibitory effect on the central nervous system, a decrease in the anticonvulsant efficacy of carbamazepine and a decrease in the concentration of amitriptyline in the blood.
6. Can amitriptyline be taken with phenazepam? Such drugs can be prescribed in parallel only in short courses, to speed up the relief of symptoms and reduce the side effects of the antidepressant.
7. Is there compatibility between amitriptyline and cinnarizine? Appointment, perhaps, but under the supervision of a doctor, since in this combination the effect of the antidepressant will be enhanced.
8. What is the compatibility of fluoxetine and amitriptyline, can they be combined? Fluoxetine is also an antidepressant, but from a different group and with a different mechanism of action. The combination is possible using the minimum therapeutic doses of drugs and only as prescribed by a doctor, but it is dangerous for the development of side effects.
9. Is Velafax compatible with amitriptyline? It is also an antidepressant, the mechanism of action of which is different. A combination of them is possible, but taking the drugs is divided by time - "Velafax" in the morning, and amitriptyline in the evening at a lower dose and be sure to monitor the reaction of the body in order to exclude a depressant effect on the central nervous system.
10. Is amitriptyline compatible with piracetam? Nootropics are not recommended to be combined with antidepressants due to the difference in their action - stimulating versus calming. The effectiveness of the two drugs may decrease and the risk of side effects may increase. If such a combination is prescribed by a doctor, then it is advisable to divide the intake of tablets by time.
11. Is it possible to drink amitriptyline and Paxil at the same time? These are two antidepressants from different groups. This combination is used, but cannot be taken on its own, as there is a risk of enhancing the effects of both of them.
12. What is the compatibility between amitriptyline and Eglonil? It is an antipsychotic with an antipsychotic effect, therefore, when used together, there is a risk of increasing the inhibitory effect on the central nervous system. If such a combination is practiced, then the drugs are prescribed at different times.
13. Can I take escitalopram with amitriptyline? Combining two antidepressants is not always appropriate. Sometimes this combination is practiced for severe depression, but the best therapeutic effect develops with a combination of an antidepressant and a tranquilizer.
14. Is it possible to take Afobazol and amitriptyline together? The drugs are compatible since "Afobazol" refers to tranquilizers and is often prescribed in combination with antidepressants. But against the background of a stronger amitriptyline, the effect of Afobazole may be lost, therefore, only a doctor should deal with the selection of therapeutic doses.
15. Can amitriptyline and Atarax be taken together? This is a drug from the group of tranquilizers, so it is likely to be combined with amitriptyline in depressive states. But they must be taken at different times.
16. Are there drugs similar to amitriptyline that can be bought without a prescription? There are light over-the-counter drugs, the effect of which can be attributed to antidepressants - Persen, Novo-Passit, Deprim, Azafen and others. But selling medicines without a prescription does not mean that you can prescribe the treatment yourself!
17. Can amitriptyline and Finlepsin be taken together? The drug is used to treat epilepsy, as well as neuralgia and pain syndrome, therefore, it is likely that amitriptyline will increase the inhibitory effect on the central nervous system or decrease its concentration in the blood.
18. Can amitriptyline be taken as a sleeping pill? When insomnia is not associated with depression, the drug is not indicated.
19. If you take amitriptyline frequently, what are the consequences? Long-term continuous treatment is always associated with a high risk of side effects. Therapy with such a serious drug should be carried out only under the supervision of a physician and in adequate doses.
20. Can you give amitriptyline to a drunk person? No, it is absolutely incompatible with alcohol!
21. Does amitriptyline have a cumulative effect? Yes, the therapeutic effect of this medicine is cumulative and fully occurs in 2-3 weeks.
22. Why get fat from amitriptyline? One of its side effects is increased appetite. Sometimes this leads to weight gain.
23. Does amitriptyline raise or lower blood pressure? The drug is able to both reduce and increase it. Jumps in indicators can be observed during the day.
24. How to get rid of weakness after taking amitriptyline? Addiction to the drug lasts for 7-14 days. If the condition does not improve, you should reconsider the dose or change the medicine to another one.
25. How long does amitriptyline last? The active substance enters the bloodstream within 30 minutes after ingestion and remains there for about 7-10 hours (maximum 28 hours). Approximately so much one accepted dose of the drug acts.
26. How long does it take for amitriptyline to be cleared from the body? Its complete elimination occurs 7-14 days after the end of the intake.
27. Which doctor prescribes amitriptyline? - psychiatrist.
28. How long can I take amitriptyline without a break? The course of treatment is a maximum of 8 months.

Amitriptyline is a potent drug that belongs to the "old" generation of antidepressants. Its severe side effects sometimes outweigh the benefits of treatment. Therefore, the decision to take it should be made only by a doctor. Self-prescription of such a medicine is life-threatening!

Despite this, this drug is now widely used for such problems as emotional disorders and other diseases, which will be described below.

Despite the presence of a considerable number of side effects of Amitriptyline, this drug is quite well tolerated by most patients, but subject to strict observance of all required precautions. It is necessary to take the drug exclusively under the supervision of the attending physician and, if any changes occur in the body, inform him about it in order to prevent or correct side effects.

Why does Amitriptyline have so many side effects?

Amitriptyline is prescribed for depression of various origins, for mixed-type emotional disorders, behavioral disorders, phobias, psychogenic anorexia or bulimia, and migraine. The use of this medicine in the treatment of children for enuresis (urinary incontinence) is allowed.

This drug is an antidepressant, which is part of the group of tricyclic compounds. Its job is to prevent the secondary capture of those substances that transmit nerve impulses in neurons (norepinephrine, acetylcholine, serotonin, dopamine), so their number in the brain increases. It is with an excess of the above substances that most of the side effects of the drug are associated.

In order for the patient to avoid unpleasant effects as much as possible when taking the drug, it is necessary to take into account all the features of the mechanism of its action before using the drug. This can only be done by a specialist, so do not start taking an antidepressant without consulting a doctor. Side effects due to the suppression of acetylcholine. Acetylcholine, as a substance that transmits nerve impulses, is responsible for causing some physiological effects. The anticholinergic effect, that is, the termination of the action of the substance, can have the opposite effect. Usually, the consequences appear already at the first stage of treatment with Amitriptyline. And here are the following side effects:

1. The iris of the eye does not contract, so the pupil stops responding to light and stops at the dilated stage. Vision becomes blurry as a result. An increase in intraocular pressure is possible.
2. Decreased salivation, dry mouth.
3. Suppression of the motor muscles of the intestine, which entails constipation and, less often, intestinal obstruction.
4. Suppression of motor function of the urinary tract. Hence urinary retention.
5. Increase in body temperature.

Side effects concerning the nervous systems

Since Amitriptyline is a drug that has a psychotropic effect, in the area of ​​​​the central and peripheral nervous systems, patients may experience certain side effects:

1. General weakness, high fatigue.
2. Poor sleep, nightmares, difficulty falling asleep.
3. Migraine.
4. Dizziness.
5. Increased irritability, anxiety.
6. Ataxia as one of the disorders of motor skills and similar to it, a violation of coordination of movements.
7. Decreased concentration, difficulty pronouncing individual sounds or even words.
8. Violation of sensitivity.
9. Less common is confusion, impaired orientation to the terrain, hallucinations can be a possible side effect.
10. Seizures.

Side effects regarding other organs and systems

If Amitriptyline is prescribed, the instructions for the use of the drug are signed by the doctor. In the area of ​​the circulatory system, changes such as increased heart rate or simply a violation of its rhythm, jumps in blood pressure, signs of heart failure, and short-term loss of consciousness can be observed.

As for the state of the blood, a change in the level of sugar is possible, as well as a decrease in the total number of leukocytes and platelets. The second leads to a decrease in immunity and increased bleeding.

On the part of the gastrointestinal tract, such reactions to Amitriptyline as nausea and vomiting, heartburn, stomatitis, change in taste, pain in the abdomen, constipation or diarrhea (may come alternately) appear. Possibly impaired liver function. In the process of taking Amitriptyline, hormonal disorders can be observed, manifested in breast enlargement in both men and women; discharge from the mammary glands; sexual dysfunction.

Other side effects include hair loss of varying degrees, weight changes - more often upwards, as well as profuse sweating, various allergic reactions, such as rashes, discharge on the skin.

Amitriptyline: instructions for use

Amitriptyline is prescribed for oral administration immediately after meals. It is undesirable to chew the tablet to ensure minimal irritation of the walls of the stomach. The first dosage is mg and is taken by an adult patient at bedtime. For five days, it is necessary to increase the dose to 200 mg per day in three divided doses. If the effect does not occur within two weeks, it is possible to increase the dose by another 100 mg.

If Amitriptyline is administered as a solution, then it should be administered both intravenously (slowly) and intramuscularly. The dosage is 4 times a day with a gradual transition to the oral route of administration of the drug.

The course of treatment with Amitriptyline should not exceed eight months.

If no changes are observed after three to four weeks, then continued treatment with the drug is not advisable and can lead to negative consequences and deterioration in the condition of the patient taking the drug.

Antidepressant "Amitriptyline". Reviews about the drug

A classic and highly effective tricyclic antidepressant is Amitriptyline Nycomed. Reviews about him are usually positive. This medicine has a wide range of applications.

pharmachologic effect

The drug "Amitriptyline" is an antidepressant from a number of tricyclic compounds. It is a derivative of dibenzocycloheptadine. The action of amitriptyline is associated with the stimulation of serotonergic and adrenergic mechanisms of the brain by suppressing the reuptake of mediators. It gives a sedative effect, exhibits antihistamine and anticholinergic activity. The antidiuretic benefit in nighttime incontinence is achieved through anticholinergic activity. The drug has an analgesic effect, which is believed to be associated with changes in the concentration of monoamines in the central nervous system and the effect of tricyclic compounds on opioid endogenous systems.

Pharmacokinetics

It is believed that the drug "Amitriptyline" has good bioavailability. Reviews usually confirm this. The bioavailability of the drug is 31-61%. It binds to blood proteins by 82-96%. Metabolization is carried out with the formation of the metabolite nortriptyline (active). The half-life is h. The drug is excreted mainly through the kidneys.

Indications

The drug is used during the depressive phase of manic-depressive psychoses, various depressions (including children's), with mixed emotional disorders, with pathological behavioral disorders. In children's enuresis (with the exception of patients with hypotonic bladder pathology), the medicine "Amitriptyline" has proven itself quite well. Reviews about its action are good. The drug is also prescribed for bulimia nervosa and chronic pain syndromes. Also, this remedy is prescribed for the treatment of bulimic neurosis, psychogenic anorexia, with chronic neurogenic pain, in order to prevent migraine.

Dosing

Amitriptyline tablets are taken orally (without chewing) after meals. For adults, the initial dose is 25 mg 2 to 4 times a day. The maximum dosage for outpatient treatment is 150 mg per day, for inpatient treatment - 300 mg per day, and for the elderly 100 mg. The medication can be administered intravenously or intramuscularly pomg four times a day. Over time, injections can be replaced by oral administration. The course is no more than 6 months. For children, the drug is prescribed as an antidepressant in dosages of -mg, for adolescents - 10 mg three times a day, for the treatment of enuresis in children over the age of six - mg at night. The dosage should not exceed the proportion of 2.5 mg per 1 kg of body weight.

Side effects

As a rule, the medicine "Amitriptyline" is well tolerated. Feedback on the use is positive. However, various side effects are possible. CNS: disorientation, hallucinations, drowsiness, extrapyramidal disorders, fatigue, anxiety, trembling. Cardiovascular system: tachycardia, orthostatic hypotension, conduction disturbance. Gastrointestinal: cholestatic jaundice, vomiting, stomatitis. Reproductive system: delayed ejaculation, various disorders, changes in libido, decreased potency. Endocrine system: diabetes mellitus, glucosuria, hyperglycemia, decreased glucose tolerance, inadequate ADH secretion. Metabolism: weight gain. Allergic reactions: skin rashes, itching. Effects caused by anticholinergic activity: disturbances of accommodation, dry mouth, urinary retention, increased intraocular pressure, blurred vision, constipation. Side effects occur infrequently when taking the medication "Amitriptyline". Reviews about it are generally positive.

Contraindications

The drug should not be prescribed against the background of the following diseases: with angle-closure glaucoma, atony of the bladder, prostate hypertrophy, paralytic ileus, pyloric stenosis, epilepsy, early recovery period after a heart attack. The drug also can not be used simultaneously with MAO inhibitors. It is also contraindicated to use the drug for decompensated heart defects, blood diseases, glaucoma, severe liver and kidney diseases, stomach ulcers and hypersensitivity to the active substance and other components of the drug.

Pregnancy and lactation

The drug "Amitriptyline" should not be used during pregnancy, and especially in the 1-3 trimesters. The use of the drug is allowed only when absolutely necessary. The fact is that adequate clinical studies of the effect of the drug on the fetus and the mother's body have not been conducted. Therefore, it is not known how safe it is. In experimental studies, the drug gave a teratogenic effect in dosages much higher than normal.

special instructions

With great care, this drug is used for heart failure, arrhythmias, coronary artery disease. Abrupt discontinuation of medication can lead to the development of a withdrawal syndrome. This tool can be used no earlier than two weeks after taking MAO inhibitors. You can not use the drug simultaneously with sympathomimetic medications: with epinephrine, isoprenaline, ephedrine, phenylephrine, norepinephrine, phenylpropanolamine. With great care, this medicine is prescribed together with drugs that have an anticholinergic effect. Do not drink alcohol while taking the medication. Means "Amitriptyline" affects the ability to control mechanisms. During therapy, it is necessary to refrain from activities associated with a potential hazard, requiring a good reaction rate and increased attention. This drug was included in the list of essential drugs. With an overdose of Amitriptyline, the following symptoms are observed: disorientation, drowsiness and confusion, fever, dysarthria, shortness of breath, dilated pupils, hallucinations, stupor, convulsions, arrhythmia, muscle rigidity, hypotension, respiratory depression, heart failure.

drug interaction

As a rule, with the simultaneous use of Amitriptyline with other drugs that have a depressant effect on the central nervous system, as well as with alcohol, an excessive increase in depression of the central nervous system is possible. The effect of alcohol is enhanced. In addition, hypotensive effects and respiratory depression may be observed. If you take the medicine together with other drugs that are characterized by anticholinergic activity, it is possible to increase the anticholinergic effect. Taking the drug "Amitriptyline" with symptomatic medications enhances their effect on the heart and the cardiovascular system as a whole. Because of this, the risk of developing various rhythm disturbances, arterial hypertension (severe forms), and tachycardia increases. Reception with guanethidine and clonidine reduces the hypotensive effect of these drugs. Use together with barbiturates: with quinidine - slowing down the metabolism of the drug "Amitriptyline", with carbozepine - a significant decrease in the effect of the drug due to the strong acceleration of its metabolism. Simultaneous use together with cimetidine also slows down the metabolism of Amitriptyline, and also increases its plasma concentration and increases the risk of toxic effects.

Antidepressant "Amitriptyline"

Manufacturer: Zentiva Pharma LLC (Russia)

Active ingredient: Amitriptyline (Amitriptyline)

Pharmacological action of an antidepressant

Amitriptyline belongs to the group of tricyclic antidepressants. Its action is based on blocking the reuptake of dopamine, serotonin and norepinephrine by CNS neurons. In addition, amitriptyline has analgesic effects, as well as antibulimic and antiulcer effects. The drug is also effective in the fight against bedwetting. With regular and sufficiently long-term use, it restores the balance of serotonin and norepinephrine transmission, shaken due to depression.

A pronounced antidepressant effect, as a rule, appears 2-4 weeks after the start of the antidepressant. In depression complicated by anxiety, amitriptyline reduces both depressive manifestations and agitation and anxiety. The antiulcer effect of the drug is due to its ability to block the work of histamine H2 receptors in the cells of the stomach. Thus, effective pain relief is achieved, as well as accelerated healing of gastric and duodenal ulcers.

The high efficacy of amitriptyline in the treatment of bulimia nervosa has not yet been scientifically substantiated. However, it is well known that the drug shows good results in the fight against this disease (at the same time, improvements in patients with bulimia occur regardless of the presence / absence of depressive conditions in them, the antibulimic effect occurs even in the absence of an antidepressant effect).

A domestic study conducted in one of the Samara clinics showed that patients feel a significant decrease in anxiety and agitation, as well as motor restlessness already in the first days of taking amitriptyline. At 2-3 weeks of treatment, patients felt an improvement in mood, an increase in self-esteem, a sharp decrease in the feeling of melancholy, depression and hopelessness. Feelings of guilt and suicidal tendencies disappeared.

In addition, there was a marked improvement in sleep among all patients treated with amitriptyline. Night sleep completely normalized, became strong and uninterrupted.

Indications for use

• treatment of depression of any origin (endogenous, neurotic, involutional, drug-induced, reactive, with anxiety, sleep disturbances and agitation, depression with alcohol withdrawal, as well as with organic disorders of the brain);
• Treatment of mixed emotional disorders;
• Treatment of schizophrenic psychoses;
• Treatment of bulimia nervosa and psychogenic anorexia;
• Treatment of nocturnal enuresis, including in children (the drug is contraindicated in patients with hypotension of the bladder);
• Treatment of phobic disorders;
• Elimination of behavioral disorders (including activity and attention);
• Peptic ulcer of the stomach and duodenum;
• Prevention of headaches;
• Treatment of patients with chronic pain syndrome (atypical facial pain, migraines, chronic pain in cancer patients, postherpetic neuralgia, rheumatic pain, posttraumatic, peripheral and diabetic neuropathy).

Method of application and dosage

Amitriptyline is taken orally during or after a meal. Start taking the drug should smg / day. The dose should be divided into several doses of 25 mg each. In order to achieve the optimal therapeutic effect, the dose may be gradually increased by nmg. The maximum allowable dosage is mg per day. In this case, most should be taken before bedtime. With extremely severe depressions that are not amenable to therapy, it is possible to increase the dose to 300 mg or even more, depending on the individual tolerance of the drug. In such a situation, it is advisable to start treatment with intravenous / intramuscular administration of the substance.

The therapeutic effect should appear no later than one month after the start of taking amitriptyline. In this case, the dosage is gradually reduced, however, if signs of depression resume, you should return to the previous effective dose. If the drug does not show effectiveness after 3-4 weeks of treatment, it should be discarded.

For elderly patients, the minimum dose is 25 mg / day, which can be increased gradually by 2 mg / day. In the prevention of headaches, as well as neurogenic pain, it is recommended to use the drug in an amount of 12.5-25 mg / day with a possible increase in dosage up to 100 mg / day.

In severe depression, the drug is administered intramuscularly / intravenously in doses, up to 3-4 injections per day. The maximum daily dose can be gradually increased and is 150 mg. After 7-14 days of injections, they switch to oral amitriptyline. Children (mandatory over 12 years old) and elderly people are prescribed the most minimal doses, increasing the dosage should be slower.

Contraindications

Amitriptyline should not be taken by people with heart failure in the stage of decompensation, impaired conduction of the heart muscle, the period of myocardial infarction (including recovery after it), arterial hypertension. It is forbidden to take the drug to patients with prostatic hypertrophy, atony of the bladder, paralytic ileus, as well as in acute violations of the liver and kidneys.

It is forbidden to take amitriptyline to pregnant women, nursing mothers, as well as children under 6 years of age (when taken orally). Patients with hypersensitivity to amitriptyline should also not take this drug.

Side effects

Blurred vision, increased intraocular pressure, dry mouth, constipation, fever. These are the consequences of the body's adaptation to the drug, so they usually disappear soon (sometimes you need to reduce the dose). On the part of the nervous system, the following side effects occur: irritability, headache, tinnitus, sleep disorders, drowsiness, anxiety, etc. In addition, heart rhythm disturbances, heartburn, nausea, vomiting, taste disturbance, enlargement of the mammary glands, as well as allergic reactions: itching, rash, urticaria. (see also Norpramin)

Storage conditions

The drug is stored out of the reach of small children at temperatures from 10 to 25 ° C in a dry, dark place.

Amitriptyline is also available under the brand names:

Conditions for dispensing from a pharmacy

By prescription.

Amitriptyline price: the function is temporarily inactive

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Antidepressant "Amitriptyline": 55 comments and patient reviews:

1. Sergey, 26, St. Petersburg Post author

I take for depression, almost a month, 50 mg before bed. I woke up, there was some kind of energy, activity. Prior to that, he took Fevarin, to no avail, with emissions into mania. In Amitriptyline, almost everything suits, but the side effects make me healthy: trouble with memory, terrible dryness, I see worse, my hands are shaking. But the antidepressant effect so far pays for this whole bouquet.

I take the 4th day from VSD, asthenia, and depression, the doctor said two tablets (50 mg) a day, on the first day I almost went crazy, I lowered the dose to 0.5 twice a day, now I suffer from insomnia, dizziness, I can’t nothing to focus on. I knew that the first days would be hard but not the same ..

Hello, I have been taking amitriptyline for two weeks and it seems to me that anxiety, fear, fear have become less. That's just vision and memory worse

I was betrayed by a close person. It was a strong blow for me. She drank amitriptyline for six months, up to 3 tablets a day. Helped. Good drug. I got a little better, but compared to what it was, it's a trifle.

1. Victoria 32

How long did it take to start helping? I have the same situation. I have been taking aminotriptyline for a week so far, only a sleepy state.

I was prescribed this drug for chronic pain syndrome. Daily headaches, weakness. In general, neurasthenia with chronic tension headaches. Have appointed or nominated 10 mg for the night. At first I drank half a tablet (5 mg). The next day there was no headache. Gradually switched to a whole tablet at night (10 mg).

What to say? I have been drinking for the third month, and they said to drink at least six months. The drug is strong, in anti-depressive doses it is almost unrealistically heavy. A lot of bad side effects, the worst of which is a cardio-toxic effect. Your heart beats so hard you can hear your own pulse in your ears.

And my head doesn't hurt.

On the one hand, it’s scary to live with such tachycardia, and on the other hand, it’s scary to quit, what if the pain returns ...

In addition, it gives constipation and greatly increases appetite, without removing the asthenic component. In general, there is zhor, but there is no cheerfulness. Hence the weight gain...

Even in such insignificant doses - 10 mg. For an AD effect, the dose should be mg.

Retirees often get lost after retirement, getting used to a regular work schedule. I was no exception - I lost interest in life, I was pressed by some kind of longing for youth, there was nowhere to put myself. A friend suggested the drug "Biotredin". And what? For me, it has become a real panacea for the blues and thoughts that life is over.

When people get sick, it is a very big grief. Lately, I've been feeling unwell myself. People need drugs like Amitriptyline. So, my mood was very bad every day. Lived like a dream. I woke up in the morning and already felt tired. My wife, she is a nurse who bought the drug from me. I want to say that he helped me a lot. Now everything is as before. I am not sad and I want to live every day, and I am grateful for that.

I take it for two weeks, they prescribed it to me after cystoscopy 25 mg, I have had urinary neuralgia for 13 years, nothing helped, there were sirashny pains, I constantly went to the toilet. And this medicine apparently heals me. It doesn’t hurt almost.

Please tell me, I have tablets of 10 mg. how many times you need to drink and how much to walk a day and it didn’t matter, excuse my French, but at night to sleep like a log and not look at the ceiling until the morning ...

The drug is one of the cheapest, which is probably why it gives so many side effects. I constantly want to sleep, my memory and vision are deteriorating, there is no strength and desire for anything. In combination with Pantogam Active, the condition improved slightly, some vigor appeared, but still, due to the lack of the desired effect, she switched to other pills.

Good afternoon! The drug was prescribed to my mother. After an ischemic stroke, she began to recover, but tantrums appeared, 4 months ago they buried her dad, she always says that he comes to pick her up. She took gidosepam, maybe from him? One way or another, after the first tablet of amitriptyline, at night, he sleeps for the second day, the nurses cannot wake up. Yesterday the therapist canceled both gidosepam and amitriptyline, said that she was just sleeping. Today they called an ambulance, they say that she is unconscious, they are waiting for a therapist and a neuropathologist. I’m in Moscow, I just returned yesterday, my mother is in Ukraine, I don’t know what to do, I don’t trust local doctors anymore, I read somewhere that amitripcilin is generally contraindicated in cardiovascular disorders. If anyone can give some good advice, please help. Thank you!

I tried to take it from a small dose, I couldn’t, my heart-beat increased and there were interruptions in the heart rhythm. I drank 3 days for 1/4 25 mg. I had to cancel. Tried 3 times to start, the result is the same.

Hello everyone, after the second injection I stopped the treatment, the condition was terrible, can anyone tell me when they completely go away from amitriplin?

1. Dmitry

did it go away soon after you finished taking it? I have the same situation .. if anything, please write to the mail

There were headaches as if the helmet on the head didn’t get enough sleep, irritated the lamp light, especially in the rooms and headlights of the cars, the doctor diagnosed depression, started taking amitriptyline, after 3 weeks, blood pressure started in a dream, I jump up from the fact that the heart is running, panic sets in, this didn’t happen, everything that didn’t exist at all It's dangerous and I don't know what to do.

I took amitriptyline for 3 months. I started to reduce the dose to 1/4 at night. Nothing happened in the afternoon, and alarming symptoms began again in the morning. what you need. So I don’t know which is better?

My mother-in-law was prescribed this drug. She had fears, panic, an excited state. After taking it, everything went well. Now there are exacerbations, we immediately begin to give these pills and she calms down on the third day approximately. Complains of dry mouth only and for memory. And so all is well.

He used drugs for many years, then he began to drink heavily. Now I take amitriptyline, depression and anxiety disappeared, I sleep soundly (2 tablets in the morning). I got a job, started a family. Amitriptyline is a remedy for drug and alcohol addiction. Of the "side effects" - dry mouth, worsened memory, attention.

Three times in my life, amitriptyline helped me like no other remedy, when stress accumulated and a state of complete inability to “keep blows” and the inability to work with people, asthenia, set in. Despite the fact that as a psychotherapist she helped everyone, but she could not “rule” her life. Calm set in, anxiety, tearfulness, uncertainty, fear of circumstances disappeared. Only dry mouth is a side effect. The previous time I started drinking with 25 mg 3 times a day, without increasing the dose, but for a long time (up to 9 months) on the recommendation of a doctor. Now again the same period of life. I started on my own without a doctor. But I know that you need to “leave” by gradually reducing the dose every 5 days by 1/4. Better company Nycomed. But for some reason, its reserves "melt" in the city. And 25 mg is not available at all now. And dividing the halves is inconvenient, troublesome. By the way, tell me, are they allowed to cross the borders with him?

The drug is good, for me, anyway. I drink at night. He suffered from sleep disorders, anxiety, panic, “not good” thoughts, depression in the morning, fatigue, etc. Has started to drink amitriptyline - everything is OK. At first - yes, the next day, fatigue, lethargy, attention disorder, but this lasted about a week. Adjustment period as far as I can tell. After - and working capacity, and vital energy, and there are no "not good" thoughts.

I have been taking the drug since the summer in combination with chlorprothixene. At the beginning, there was no effect, there were side effects, mostly dryness was very strong, but after a month everything went away, I went to work, everything is super. Now I take 25 mg in the morning, 25 mg in the afternoon and 50 mg at night, I tried to reduce the doses with the doctor, but so far it has not worked out, he said that again 3 months. drink, and then to decline. The dream is wonderful, only attention is very disturbed, another medicine was prescribed for attention, I drank the course and it became easier.

1. Lydia

What other drug did you take, please write. Because. Amitriptyline impairs memory and makes addictive, and the pressure rises with prolonged use. I have been drinking it for many years. I began to have terrible headaches, hypertension, it barely went away until the ambulance. I have now been prescribed again for an overactive bladder, frequent urination, I did not tell the doctor, but I do not want to take it anymore.

Prescribed for depression. Of course it helped. I drink for a week, I live calmly for a couple of months, not paying attention to stress. But when the effect ends, just tin, do not come up to me, I destroy everything. The other day I started drinking a quarter again, to all the side effects (dry mouth, weakness, sleep, deterioration of attention), numbness of the hands was added, the right one passed, and the left one hangs 🙁 But I can’t refuse yet, I’m afraid. And I don't know what to replace. Tomorrow to the doctor.

She took amitriptyline from him, there was dryness and an unpleasant aftertaste in her mouth, and there was a fear of communication, and the skin on her hands began to crack.

I was in a psycho-neurological dispensary, where ammitriptyline is not practiced now. They were treated with expensive, new antidepressants .... after discharge, it became bad again, evening panics were not left alone. Now I drink ambulatory ammitriptyline, I can not get enough of my well-being. only for some reason they appointed half in the morning and in the afternoon. I sleep like a horse day and night ... what should I do? Can anyone tell me if I can drink it in the afternoon. and yet, the course was prescribed only for a month, and then switch to tranquilizers, also for a month. I'm afraid to quit ammitriptyline. and he can somehow get out of depression for a month of taking it. thank you very much

1. Shurunya

maybe just lower the dose. Talk to your doctor, it is better not to joke with such drugs.

first you need to think, accept it, or you can still do without it, otherwise we eat everything that is advised and that it comes to hand.

Everything is very individual. If there are side effects that worsen the quality of life, then you need to inform the doctor. For example, they gave me strong side effects and paxil, and fluoxetine, and lerivon, but I have been living on amitriptyline for the 3rd month and working. Enjoying the life. I drank 2 months 3 times a day: in the morning 1/2, in the afternoon 1/2 and at night - a whole pill, and since November I removed the daily dose. One single side effect: I recovered by 5 kg ... But this is nothing.

I took this drug six months ago. Before I started taking it, I suffered from a terrible depression, I didn’t want to live: I blamed myself for everything, I was afraid. I began to drink amitriptyline 50 mg 3 times a day, slept from them almost around the clock, dizziness, tinnitus. But after a week, positive thoughts began to appear, the mood improved. I realized that my fears were greatly exaggerated, and now I consider my mistakes (not so terrible) as an experience. After the first improvements, I reduced the dose, although they said it was impossible, little time had passed. Stopped taking much earlier than prescribed. There was no withdrawal syndrome, since the summer I have not taken amitriptyline and everything is in order. But doctors still need to be obeyed and taken as prescribed. The drug is good, at least it helped me a lot, otherwise I didn’t get out of bed, I kept crying.

Thank you family for being patient and supporting me.

Yes, I also drank it for 3 weeks, with an increase in the dose. I had secondary depression and didn’t sleep well, so in principle he helped me! But at the beginning of day 2.3, the state was bad, everything was annoying! and after drinking the course that I was prescribed, it became somehow for everything, forgive me FSUs .... less to heart I accept everything that I really like)))

For those who are afraid to sit down. I have long been drinking courses autumn-spring. There is a natural break.

There was a time when I only drank at night. But I noticed that my heart rate increased. I divided the dose into two doses: in the morning and in the afternoon. The action is the same, but the feeling is much more pleasant.

they prescribed this muck, the state is like a coma, I’ll stop drinking them, I tried it for only three days, all three days of the state of depression, heaviness in my whole body, but I need something completely different - working capacity and a good mood, and here only some dibile calmness, two once taking 1/4 tablet caused panic attacks. no, I’d better get along without antidepressants, it’s neurologists and psychiatrists who can’t do without their appointment, let them prescribe them to those who have MDP, and not VSD. I only feel better before them, on you - all this amitriptyline ruined.

1. Elena

I also took this drug and the effect was exactly the same as you described. Then I tried stimulatone and now it helped me. Just amitriptyline is suitable for those who are overexcited and anxious - it calms. And if you wanted to increase efficiency, then I think drugs that excite the nervous system will help, Phenotropil also applies to them.

I just started drinking amitriptyline 1/6 at night. Guys, a young man left me, these pills in a small dose help a lot, I forgot about him and now I don't care who he is and what he is!))))))))))))))))))))) I get high

After taking it, side symptoms were very pronounced - half of the body was generally numb, especially the next morning (after 2 tablets at night), dry mouth was terrible, I quit drinking it, nafig, it looked like withdrawal for another 2 days, PPC. glitches began to catch in the minibus. I won't touch this crap anymore.

1. Saratov 18

I agree with Dmitry. my condition was terrible - heaviness. dry mouth and glitches on the bus, I came home and fell asleep in unconsciousness. the dream lasted an eternity, and fell asleep only for an hour.

Good afternoon, I used to take amitriptyline, but then it stopped helping, a year ago I started taking it again, and it helped for the time being. I want to know how long the body should rest after taking amitriptyline ...

I’m saved only by him ... .. I’m already afraid that I won’t sit on it and become addicted .... It helps with headaches when you want to sleep, but the brain doesn’t turn off at all ... and in the morning you get up in a terrible mood and condition .... So that's just I am saved by them, I try to drink only at night ....

what happens if you drink 2.5 packs of amitriptyline

I had postpartum depression. It helps, of course, only it is necessary that there is time for rest during the day. I took it at night, 2-3 hours before bedtime. Then it’s as if they turn you off and you sleep peacefully. Create conditions for yourself. Meditation to the sounds of nature also helps. 😎

Zoloft was prescribed 1.5 years ago, she took it for 3 months. The condition returned to normal, I was sure that it was forever. But now the disease began to return, first through sleep, whatever it was, then panic attacks began in the afternoon. I tried to fight myself, now knowing what it is, but it didn’t always work out. I had to go to the doctor again, because it interferes with normal life and work (work requires a lot of attention and concentration). They prescribed amitriptyl nycomed and in parallel a bunch of other drugs related to the normalization of the work of blood vessels (system, injections). I tried to ask the doctor a question what is the difference between Zoloft and amitriptyline (the difference in price is 10 times) - she did not "plainly" explain. I tried to "dig up" info on the net, but I could not figure it out myself. Please, if someone has info about the difference in these drugs, then please answer. Thanks in advance.

This drug helped me, with an overactive bladder on a nervous basis, it was the only thing that saved me, but I didn’t get out of the toilet.

1. planet

Yes, I have the same story with my bladder. I thought at first that it was cystitis and ate kanefron. But now I understand that this is also VVD ((. This amitriptyline suits me in everything: it removes heartburn, and allows you not to run small every half an hour during exacerbation and sleep is better and migraine pains! BUT 🙁 ((if I eat it at least I’d like a quarter of 25 mg, my pulse is hammering and I become like a vegetable with dereal and panic covers. There is an exacerbation of the rest of the VSD symptoms. It’s a pity, but drinking it less than a quarter is probably just pointless. I already broke off half a match head at the end , but the desired effect was no longer there.Cipralex, Paxil didn’t suit me either.Now I don’t even know how to be treated 🙁 my VSD does not disappear to the end.

Very good drug, time-tested! Thanks to him, she got back on her feet, after a deep depression, and even went to work.

1. Veronica 32

What dose did you take? Thanks in advance.

If you take one tablet at night of 25 mg, you can get a great night's sleep. As an antidepressant in small doses, it is ineffective.

the drug really helped, but on the 2nd day of taking it, quite pronounced side effects appeared: thirst (constant and moreover), pain in the heart (passed shortly after the course), and disturbing dreams, nightmares (for me personally, this is the most problematic) .. but during the day I felt quite cheerful and confident .. my advice: if possible, take more “soft” drugs .. - too “vigorous” in my opinion ..

it's a drug you want to live off of :angel:

A cure for major depression that actually helps. I experienced it from my own experience once ... when it was unbearably painful in my soul, I swallowed a couple of pills, after some time drowsiness rolled in and usually passed out to sleep, right in the middle of the day. in the morning I felt cheerful, satisfied and full of energy: love: it was true three years ago ...

I take amitriptyline at night, it helps a lot as a sleeping pill - it makes me sleep without hind legs. If you drink during the day, there is a feeling of drowsiness and relaxation, which can interfere when there is a lot to do. But when you need to rest, preprat most it. Anxiety and anxiety go away and a feeling of peace remains. In addition, it is also inexpensive, the price of amitriptyline, unlike other antidepressants of this level, does not bite.

1. Alexey, 31 years old, Yaroslavl

The effect of amitriptyline is as follows: the mood improved by a “drop”, and memory and attention worsened by a whole “rain”!

Our grandmother was once prescribed this drug, it protects against depressive states. She had suicidal tendencies, and when she took amitriptyline, it all went away.

1. Radik, 51 years old, Ufa.

I drink amitriptyline 100 mg for 20 days, the diagnosis is a daily chronic headache, stress for many years, while there is no sense in drinking at random, it can help.

Before that I drank Prozac for 1 year.

I drank Velafax 375mg + Mirtazonal 30mg for 6 months, to no avail .. Botox injections, I think it's worth it.