Dosage of loratadine for children of various ages. At what age can loratadine be given to a child, and at what dosage

Most mothers are faced with allergies in their child. It occurs due to increased sensitivity to food and detergents, contact with animals and plant pollen, taking medications, drinking drinks.

An effective antiallergic agent is Loratadine. Our review, as well as the reviews of doctors and parents of baby patients, will help you get an idea about the drug, what drugs you can combine it with, how to correctly calculate the dosage depending on the age of the child, which can be replaced if necessary.

Loratadine - antiallergic drug long-acting.

There are three forms of release:

• Tablets for oral administration- yellowish or white with or without a chamfer, cardboard packaging of 10, 20, 30 pieces. average cost- 20 rub.
• Effervescent tablets, soluble in water- white, greenish or with a yellow tint, carton pack of 10, 20 or 30 pieces. average price- 100 rubles
• Syrup- available in dark glass or plastic containers, volume 100 ml, measuring spoon included, sold at an average of 180 rubles. for a bottle.

The syrup can be taken from two years.

Composition and pharmacological action of Loratadine

The main active ingredient of the drug is also called loratadine.

It blocks the receptors responsible for the reaction to allergens, and does not allow the release and penetration into the blood of histamine, bradykinin, leukotriene, which cause an allergic reaction and swelling.

A drug has bronchodilatory and antispasmodic properties, does not depress nervous system.

The composition of the tablets also includes additional ingredients: starch, stearin, microcrystalline cellulose, lactose (monohydrate).

Loratadin syrup, in addition to the main component, contains sugar, citric acid, propylene glycol, flavoring and purified water.

Sodium carbonate added to effervescent tablets lemon acid, povidone, colloidal silicon dioxide, polysorbate, tal, magnesium stearate, starch, macrogol, lactose monohydrate.

Indications and dosage

Loratadine is taken for:

• insect bites;
• drug intolerance;
• dermatitis;

The medicine will help with dermatitis.

• conjunctivitis;
• serum sickness;
• bronchial asthma of non-infectious type.

The remedy is also prescribed for rhinitis, edema and other types of allergic reactions.

• children from 2 to 12 years old - 1 time per day 10 minutes before meals, dose - 5 mg;
• from 12 years old - 10 mg 1 time per day 5-10 minutes before meals.

The drug within 24 hours affects allergic symptoms:

• eliminates sneezing, coughing, itching, suffocation;
• relieves reaction to vaccinations;

• reduces painful itching and discomfort with chickenpox, eczema, hay fever.

After receiving, action begins after 3-4 hours, and the maximum effect is manifested after 8 hours.

Download instructions for use in pdf format →

Contraindications and side effects

A drug contraindicated in children under 2 years of age, pregnant women while breastfeeding. AT rare cases the following adverse reactions may occur:

1. Respiratory disorders: shortness of breath, cough, runny nose, nasal congestion, feeling of pressure in the chest, spasms of the upper respiratory tract.
2. Negative effects from the nervous system- arise due to the indirect toxic effects of loratadine on the central nervous system and manifest themselves as:

• headache;
• insomnia;
• depression;
• tremor - trembling of the limbs;
• decreased attention;
• numbness in arms and legs.

Taking the drug can cause myalgia - pain in the lower extremities, arthralgia - joint pain, cramps. The cardiovascular system may respond with tachycardia, arrhythmia, high pressure, vascular tone, but side effects this kind was seen in isolated cases. In the digestive system, problems arise due to effects on the tissues of the gastrointestinal tract:

• nausea, loss or increase in appetite;

Possible adverse reaction- Abdominal pain and nausea.

• gastritis, hyperemia;
• stomatitis - inflammation, redness of the oral mucosa, accompanied by swelling, soreness, plaque;
• hepatonecrosis;
• xerostomia - dry mouth.

Allergy to an antiallergic drug. As paradoxical as it may seem, even antihistamines can create problems due to intolerance to the components - urticaria, redness, Quincke's edema, anaphylactic shock.

How it interacts with other drugs

When taken together with cimetidine, ketoconazole, rifampicin, the concentration of loratadine in the blood increases, which can lead to overdose and poisoning.

Loratadin's analogs

If Loratadine is not in the pharmacy, pay attention to antihistamines with the same active ingredient:

• Claritin - available in the form of syrup and tablets. Can be taken from 2 years old. The average cost of syrup is 250 rubles, tablets (10 pcs.) - 225 rubles.
• Lomilan - suspension in 120 ml bottles, average price - 125 rubles. and tablets (10 pcs.) -120 rubles.
• Erius - tablets are taken from the age of 12; syrup - from 2 years. The average cost of tablets (7 pcs.) - 250 rubles, syrup (60 ml) - 600 rubles.
• Loratadin-Stoma - tablets of 10 pieces in a blister, cardboard packaging. Approved for admission from 12 years. The average price of the drug is 30 rubles.

As antihistamines, preparations with other active substances are also presented, among which the most popular are:

• Cetirizine. The main component is cetirizine hydrochloride. Drops (10 ml - 200 rubles) are allowed from 1 year old, syrup (60 ml - 239 rubles) - from 3 years old, tablets (10 pcs. - 80 rubles) - from 6 years old.

An analogue of Loratadine is Cetirizine.

• Diazolin - 10 tablets or tablets in blisters, the main substance is mebhydrolin napadisilate. Reception is allowed from the age of 12, the average cost is 30 rubles.
• Zyrtec tablets or drops active substance- cetirizine hydrochloride. Appointed from 6 years. The average price of tablets is 180 rubles, drops - 230 rubles.
• Suprastin - tablets with a facet or syrup, the main component is chloropyramine hydrochloride. Admission from 3 years old. The average price of tablets is 150 rubles, syrup - 190 rubles.
• Cetrin - 20 tablets (10 mg cetirizine) film-coated in a blister, prescribed from 6 years old, the average selling price is 110 rubles.
• Tavegil - white tablets with a bevelled edge, the main active substance is clemastine hydrofumarate - 1.34 mg. Appointed from 6 years. The average cost of the drug is 230 rubles.
• Zodak. Active ingredient- cetirizine dihydrochloride. Drops (220 rubles) are allowed from one year old, syrup (130 rubles) - from two years old and tablets (310 rubles) - from 6 years old.

Analogue of Loratadin - Zodak.

Reviews of doctors and parents

Feedback from Valeria, Sonya's mother, 5 years old:

“For the summer I went with my daughter to visit my parents. The little girl ate strawberries with pleasure, and her whole body was covered with a rash. Judging by the way she scratched, the itching was intense. I immediately visited a local doctor, he prescribed Loratadine. We drank half a tablet, and the allergy disappeared as if by magic. On the second day I gave the same dose, and so for 3 days, until the rash completely disappeared.

The medicine quickly relieves itching.

Feedback from Natalia Kavalerova, mother of 8-year-old Marina:

“After consuming homemade milk, my daughter developed severe diathesis. Redness, covered with a crust, arose on the face and under the knees. The temperature has risen. The doctor prescribed Loratadine in the form of syrup. Marina drank the medicine with pleasure, after 3 days the allergy completely disappeared.

“Loratadin has many analogues. Some of them can be purchased at an affordable price, others are not affordable for everyone: Lomilan, Alerpriv, Erolin are also effective for allergies. various etiologies. There was practically no on Loratadine negative reviews from patients. I prescribe this medication more often than other antihistamines."

Usually children tolerate the drug well.

Loratadine is an effective remedy for allergies that have arisen for various reasons. At right approach to treatment, following the instructions, after half an hour of taking, redness disappears, itching stops, swelling and rashes are eliminated. However, only a doctor can prescribe the drug.

Galina Ivanova

Attention! The information is provided for informational purposes only. This manual should not be used as a guide to self-medication. The need for appointment, methods and doses of the drug are determined solely by the attending physician.

general characteristics

international and chemical name : loratadine; ethyl ether 4-cycloheptapyridine-1-piperidinecarboxylic acid;

main physiochemical properties : colorless or slightly yellowish, or slightly greenish-yellowish liquid with a specific odor;

compound: 5 ml of syrup contains - 5 mg of loratadine;

excipients: refined sugar, anhydrous citric acid, sodium benzoate, propylene glycol, glycerin, food flavor "Apricot 059", purified water.

Release form. Syrup.

Pharmacotherapeutic group

antihistamines ( Antihistamines- medicinal substances that prevent or reduce the effects caused by histamine, i.e. the effects of expanding capillaries and increasing their permeability, reducing smooth muscle etc.). ATC code R06A X13.

Pharmacological properties

Pharmacodynamics. Loratadine is a tricyclic compound of the piperidine series with a pronounced antihistamine action; has selective antagonism ( Antagonism- the type of interaction of substances, manifested in the weakening of the action of one substance by another) in relation to peripheral H1 receptors ( Receptor(Latin receptio - perception, English receptor): 1) specific sensory formations in living organisms that perceive external and internal stimuli (extero- and interoreceptors, respectively) and transform the activity of the nervous system. Depending on the type of perceived irritation, mechanoreceptors, chemoreceptors, photoreceptors, electroreceptors, thermoreceptors are distinguished; 2) active groups of protein macromolecules with which mediators or hormones specifically interact, as well as many drugs. A receptor is a conformationally flexible macromolecule or set of macromolecules, the binding to which(s) of a ligand (agonist or antagonist) causes a biological or pharmacological effects. A number of receptors exist in the form of several subtypes. There are four main types of receptors: 1) membrane receptors associated with ion channels and consisting of several protein subunits, which are located in the biological membranes of cells in a radial order, forming ion channels (for example, H-cholinergic receptors, GABA A receptors, glutamate receptors ); 2) membrane receptors coupled to G-proteins, consisting of protein molecules that "flash" biological membranes seven times; the biological effect upon activation of these receptors develops with the participation of a system of secondary transmitters (Ca2+ ions, cAMP, inositol-1,4,5-triphosphate, diacylglycerol). Receptors of this type are available for a number of hormones and mediators (eg, M-cholinergic receptors, adrenoreceptors, etc.); 3) intracellular, or nuclear receptors that regulate the processes of DNA transcription and, accordingly, the synthesis of proteins by cells. They are cytosolic and nuclear proteins (eg, steroid and thyroid hormone receptors); 4) membrane receptors that directly control the functions of the effector enzyme associated with tyrosine kinase and regulate the phosphorylation of proteins (for example, insulin receptors, a number of growth factors, etc.)) histamine ( Histamine is a derivative of the amino acid histidine. Contained in an inactive, bound form in various bodies and tissues, significant quantities released during allergic reactions, shock, burns. Calls an extension blood vessels, smooth muscle contraction, increased secretion of hydrochloric acid in the stomach, etc.). Loratadine is a long-acting drug that exhibits a complex effect, including antiallergic, antipruritic and antiexudative activity, reduces capillary permeability ( capillaries- the smallest vessels penetrating organs and tissues. They connect arterioles with venules (the smallest veins) and close the circle of blood circulation), prevents the development of tissue edema, eliminates spasms of smooth muscles. The drug and its metabolites do not penetrate the blood-brain barrier ( Blood-brain barrier- a barrier formed by the endothelium of the cerebral vessels: there are no intercellular spaces characteristic of other vessels between the endothelial cells. As a result, water-soluble polar substances do not enter the brain from the blood.) Loratadine does not have a sedative ( Sedative- a drug that has a general sedative effect on the central nervous system, without noticeable decrease physical and mental performance) effect.

Pharmacokinetics. After oral administration, the drug is detected in the blood after 15-20 minutes. The maximum concentration of loratadine and its metabolite decarboethoxyloratadine in plasma ( Plasma the liquid part of the blood that contains shaped elements(erythrocytes, leukocytes, platelets). Various diseases (rheumatism, diabetes mellitus, etc.) are diagnosed by changes in the composition of blood plasma. Medicinal preparations are prepared from blood plasma) is observed after 1 hour and lasts up to 36-48 hours. Approximately 97% of Loratadine is protein bound ( Squirrels- natural macromolecular organic compounds. Proteins play an extremely important role: they are the basis of the life process, participate in the construction of cells and tissues, are biocatalysts (enzymes), hormones, respiratory pigments (hemoglobins), protective substances (immunoglobulins), etc.) of blood plasma. The drug passes into breast milk, excreted in the urine and feces.

Indications for use

allergic rhinitis ( Rhinitis- inflammation of the nasal mucosa, runny nose) (seasonal and year-round), allergic conjunctivitis ( Conjunctivitis- inflammation of the mucous membrane (conjunctiva) of the eye. Is one of the most common eye diseases. This is due to the high reactivity of the conjunctiva, as well as the availability of the conjunctival sac. external influences), acute and chronic ( Chronic- a long, ongoing, protracted process that occurs either constantly or with periodic improvements in the condition) urticaria ( Hives- a disease characterized by the formation of limited or widespread itchy blisters on the skin and mucous membranes), Quincke's edema ( Quincke's edema - angioedema, spicy limited swelling, giant urticaria, paroxysmal limited swelling of tissues that occurs when there is a violation of the vasomotor innervation. Quincke's edema is the body's reaction to an allergen. In the affected area, arterioles and capillaries expand sharply, vascular permeability increases, and edema occurs. Externally, Quincke's edema is manifested by sharply limited swelling of tissues (mainly lips, eyelids, cheeks), sometimes skin rashes at the site of swelling, usually without itching and pain), allergic reactions to insect bites, pseudo-allergic reactions to histamine liberators, as well as contact allergic dermatitis and chronic eczema.

Dosage and administration

The drug is administered orally to adults and children over
12 years - 10 mg 2 teaspoons (10 ml) 1 time per day, children aged 2 to 12 years weighing less than 30 kg - 5 mg 1 teaspoon (5 ml), weighing more than 30 kg - 10 mg 2 teaspoons (10 ml) once a day. The course of treatment is 5-10 days.

Side effect

When using Loratadine in isolated cases, headache, dry mouth, drowsiness, nausea, allergic reactions in the form of a rash can be observed.

Contraindications

Hypersensitivity to Loratadine or any other component of the syrup. Children under 2 years old.

Overdose

When therapeutic doses are exceeded ( Therapeutic dose- dose within the therapeutic range) Loratadine 4 or more times increases the risk of side effects: drowsiness, tachycardia ( Tachycardia- an increase in heart rate to 100 or more beats per minute. Occurs with physical and nervous stress, diseases of the cardiovascular and nervous systems, diseases of the glands internal secretion etc.) and headaches.

Application features

Loratadine is not a sedative antihistamine, but some patients may experience dose-dependent sedation. The drug should be administered with caution to persons whose work is related to the management of transport or other mechanisms. In patients with impaired liver function or renal insufficiency, the initial dose of the drug should be 10 mg (2 teaspoons of syrup) every other day. During pregnancy and lactation, the drug should be used only if therapeutic effect from its use in the mother outweighs the potential risk to the fetus or newborn.

Interaction with drugs

With the simultaneous use of Loratadine with cimetidine, erythromycin, ketoconazole, an increase in its concentration in the blood serum, caused by a metabolic disorder ( Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, vital activity and self-reproduction, as well as its connection with the environment and adaptation to changes external conditions) Loratadine, probably due to the inhibition of cytochrome CYP3A4 isoenzyme by these drugs
R-450. In connection with possible development dose-dependent sedative effect care must be taken while using Loratadine with other blockers ( Blockers- drugs that, interacting with receptors, inhibit the action of an agonist) H1 receptors, barbiturates, benzodiazepines, agonists ( Agonist- a substance or drug that can interact with receptors and initiate the physiological or pharmacological characteristics of the receptor response) opioid receptors, antipsychotics ( Antipsychotics- medicinal substances that have a depressing effect on the functions of the central nervous system and can eliminate or weaken some symptoms of psychosis (delusions, hallucinations)), tricyclic antidepressants ( Antidepressants- means that improve mood, relieve anxiety and stress, increase mental activity. Used to treat depression), sedatives and hypnotics.

Product General Information

Terms and conditions of storage. Store in a place protected from light at a temperature of
15 0С to 300С. Keep out of the reach of children. Shelf life 2 years.

Holiday conditions. Without recipe.

Package. 100 ml in vials or containers.

Manufacturer. LLC "Pharmaceutical company" Zdorovye ".

Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.

Website. www.zt.com.ua

Preparations with the same active ingredient

• Loratadin - "Darnitsa"
• Loratadin - "Farmak"
• Loratadin - "Arterium"
• Loratadine tablets - "Health"
• Lorisan syrup - "Arterium"
• Lorizan tablets - "Arterium"

This material is presented in free form based on official instructions medical use drug.

Loratadine is an antiallergic drug that has an effective antipruritic and antiexudative effect. Having an anti-allergic effect, it helps to reduce capillary permeability and prevents the development of various edema. Under the influence of this drug, the contractile activity of smooth muscles is significantly reduced, which is due to the effect of histamine in the body of a sick person.

The action of the drug, the composition

The drug belongs to the blockers of histamine H1 receptors. Pharmacological properties are described in detail by the instructions for the use of Loratadine. The medicine is regular pills white or white with a yellow tint. One tablet contains 0.01 g of medicinal substance.

Being an antihistamine for systemic use, the drug inhibits leukotriene and histamine from cells. Its direct therapeutic effect begins approximately half an hour after taking the tablet inside. The action of the drug lasts a day. Loratadine does not interact with histamine receptors in the central nervous system and does not block cholinergic receptors.

The action of the drug in the treatment of allergies is based on the reaction immune system to substances that were not previously perceived by the body as foreign. The development of allergies is also facilitated by chronic inflammatory processes in the body, various stresses and even hypothermia. Loratadine prevents the release of not only histamine, but also leukotriene, serotonin, bradykinin. Stopping spasms of smooth muscles, the drug reduces exudative phenomena.

The drug is absorbed directly into small intestine. After taking medicinal substance can be detected in the blood after fifteen minutes. 97% of the drug interacts with plasma proteins. Loratadine is completely metabolized. The half-life of the drug is from 3 to 20 hours. The drug is excreted in urine and feces. The drug is not able to penetrate the blood-brain barrier.

Instructions for use of tablets

This drug is indicated for adults and children with various kinds allergic reactions. The prescribed dosage of the drug - with a sick person weighing more than thirty kilograms, the doctor prescribes 10 mg (one tablet) once a day. You can also take Loratadine for children at a dosage of 5 mg (1/2 tablet) once a day.

Loratadine is often included in a variety of nasal anti-allergic sprays. The medicine should not be taken with alcohol as toxic effect alcohol on the liver may increase.

Syrup Loratadin for children - instructions for use

Sometimes a doctor may prescribe Loratadine to children under 12 years of age. With a child weighing up to thirty kg, 5 mg is prescribed once a day. But the best dosage form for younger children is a special Loratadin syrup. As a rule, children tolerate it well, and the syrup itself does not cause any side effects, since it is a non-toxic drug.

Five milliliters of syrup contains five milligrams of Loratadine. As auxiliary substances, sugar, citric acid, propylene glycol, glycerin, sodium benzoate and food flavoring are also added to the syrup. Young children are usually happy to take the medicine Loratadine in the form of a syrup.

Children from two years of age are prescribed two teaspoons (10 ml) of syrup once a day. The course of treatment with the drug is from five to ten days, depending on the result. Usually after five days of taking all allergy symptoms in children disappear.

If the dose recommended by the doctor is exceeded, rapid heart contractions, headache, and drowsiness may occur. In the event of such reactions, urgent medical attention is required. If the prescribed dose is not observed, it is required to wash the stomach and use activated charcoal, Enterosgel, Laktofiltrum, Polysorb as therapy. Otherwise, overdose medicinal product significantly increase its toxic effects on the liver.

Indications for use

Loratadine is prescribed for allergies with allergic manifestations various origins. This histamine blocker is very effective in combating a wide variety of allergy manifestations. Main indications:

• allergic rhinitis;
• allergic conjunctivitis;
• hay fever;
• hives;
• chronic allergic reaction;
• itchy dermatosis;
• angioedema;
• allergy to insect bites;
• as an aid in bronchial asthma.

With the help of this effective drug, the manifestation of various allergic reactions can be significantly reduced. Also, the drug helps prevent further development allergies. An effective drug is also shown when the human body releases a lot of histamine. In such a situation, the patient develops a pseudo-allergic reaction.

With prolonged use, Loratadine does not cause absolutely no addiction. Therefore, the drug can be used for a sufficiently long period. The course of treatment depends on the symptoms and characteristics of the human body. Before conducting diagnostic allergy tests, it is required to stop taking the drug forty-eight hours before the proposed study. Otherwise, the result of the obtained analyzes may not correspond to the real one.

The drug is not toxic. However, children are advised to prescribe it from the age of two. You should also carefully prescribe the drug Loratadine to patients with hepatic and renal insufficiency.

Analogues

This effective selective blocker is also available under the names Loratadine Teva and Lee Loratadine. These drugs significantly reduce the expression of the desired molecules and cytokines. Medicines practically do not have a sedative effect, and also do not affect the patient's central nervous system and do not potentiate the effect of alcohol. Also, the drugs do not cause any dysfunction. of cardio-vascular system and do not disturb the rhythm of the heart.

Analogues of Loratadine are very similar in their pharmacological effects on the patient's body and in their indications for use. Medicines that are similar in action are:

• Agistam;
• Cetrin;
• Filtrum-sti;
• Tavegil;
• Suprastin;
• Eden;
• Primalan;
• Advantan;
• Diazolin;
• Elocom;
• Levocytirizine;
• Erides.

The drugs are indicated by allergists for seasonal and persistent allergic rhinitis, chronic idiopathic urticaria, Quincke's edema, various allergic reactions, including insect vinegars. With the development of acute food allergies, Loratadine is also prescribed in tablets for adults and in syrup for children from two years old. Each analogue of Loratadine has its own specific cost, which is different in various domestic pharmacies.

The same active ingredient as in Loratadine is also found in Claritin, Clarinase, Clarotadine. Their daily therapeutic dosage corresponds to the dosage of Loratadine. To last generation very effective antihistamine drugs include Aerius, Ceterizine, Zyrtec. Data effective medicines have the most minimal side effects and are not toxic. Their cost is slightly higher than the listed medicines.

How long can the drug be taken?

The individual dosage of the drug depends on the age of the patient. The weight of the patient also plays an important role. The duration of taking the medicine depends on the expressed symptoms of the disease and is determined by the attending doctor.

Before taking, it is important to carefully read the existing annotation of the drug, which includes a description of the drug, methods of its administration, indications for use and main contraindications for taking this medicine.

Contraindications for use and side effects

Like any drug, the drug Loratadine has its own contraindications for use. Main contraindications:

• drug intolerance;
• pregnancy;
• lactation;

Loratadine is prescribed with caution to those who drive a vehicle, since when taking this medication, a decrease in concentration is possible.

Of the side effects in clinical patients, minor headaches, vomiting, nausea, disorders in the liver, kidneys, fatigue and sleepiness. Also, side effects can be:

• hyperemia;
• nasal congestion;
• sneezing
• sinusitis;
• anorexia;
• flatulence;
• menorrhagia;
• visual impairment;
• dyspepsia;
• taste disorder;
• tearing;
• diarrhea;
• constipation;
• noise in ears.

In the presence of various side effects when taking the drug, it should be stopped immediately and consult with your doctor about the further use of the drug. It is possible that the doctor will stop this drug and prescribe another one that will not cause unwanted effects in the body.

Loratadine during pregnancy and lactation

In the process of gestation, Loratadine is not recommended. Its components can have a negative impact on the developing fetus and contribute to the development of the unborn child. various pathologies in the body. Loratadine during pregnancy can be prescribed only in extreme cases under strict medical supervision and in moderate dosage when it comes to the benefits of maternal health.

Also, the drug can have a negative effect on the newborn who is breastfed. Loratadine easily passes into breast milk, therefore, during lactation this drug should not be taken by a nursing woman. During pregnancy and lactation, it is required to prescribe other homeopathic antiallergic drugs that cannot have a negative and negative influence on a child.

Interaction with other drugs

The action of Loratadine is enhanced by drugs such as erythromycin, ketoconazole, cimetidine. At simultaneous reception these medicines with Loratadine significantly increases the concentration of the latter in the blood. Also, a sick person should not take a drug with drugs that inhibit isoenzymes.

The effectiveness of Loratadine is reduced by inducers of microsomal oxidation: ethanol, phenytoin, zixorine, barbiturates, rifampicin, tricyclic antidepressants.

Price

Today, the drug Loratadine can be found in most domestic pharmacies. The price for it depends on the region and may vary slightly. The average cost of a drug in a pharmacy network:

• tablets in a package - from 16 to 23 rubles;
• syrup - from 120 to 130 rubles.

Being a blocker histamine receptors, the drug Loratadine is very effective in the treatment of a wide variety of allergic reactions. With this efficient medicinal product food allergies and allergic reactions to insect stings are also treated.

This drug is capable of short term save a sick person from edema, rash, itching and burning of the skin, allergic rhinitis and tearing, prevent the further development of acute allergies, and nullify all the patient's symptoms.

Feedback on the application

Review #1

The substance in the preparation Loratadine really effectively helped me with sudden development allergic rhinitis. Before him, I used a lot of different antihistamines, which I had heard a lot about. No matter how colorful the packaging of allergy medications is sold in pharmacies, few of them gave the expected result.

About three years ago, I discovered that I was overtaken by a seasonal summer allergy. Before that, I did not suffer from this disease at all. But apparently all good things come to an end. All of a sudden I got strong allergic rhinitis. At the same time, tears rolled down the cheeks continuously. At first, I suspected an ordinary cold, but my health only worsened.

The doctor diagnosed her with seasonal allergies. Until the visit to the doctor, I could not understand what was happening to me. When analyzing my well-being, I agreed with the doctor that I have a banal allergy to flowering plants. After another attack, I bought Loratadin at the pharmacy, not really hoping that this medicine would quickly help me cope with allergies.

Firstly, it seemed to me quite cheap in cost. Secondly, having tried a lot of drugs, I didn’t really hope to find one that was already quite effective and efficient. To my surprise, the allergic rhinitis began to disappear after the first day of taking Loratadine. Now, as soon as I start to "sneeze" and tears in the summer, I always keep this effective and affordable medicine on hand. The substance Loratadine is also part of the more expensive Claritin. But I don’t see the point of overpaying for the medication, so I use the usual Loratadine. I recommend everyone who suffers from various forms of allergies to try this medicine.

Lydia, 48 years old - Chelyabinsk

Review #2

My condition is much worse in spring than in summer. I am saved only by these white pills Loratadin. In general, since childhood I have been a strong allergic person - my body reacts terribly to the flowering of certain herbs and to pet hair. Before Loratadine, an allergist prescribed me the antibiotic azithromycin for an allergic reaction.

But after using it, a terrible, itchy rash appeared on my body, which annoyed me very much. I had to urgently, in the literal sense of the word, save myself with Loratadin. This medicine is very effective! It was prescribed to me by an experienced dermatologist along with a light hypoallergenic diet.

Loratadine quickly coped with the red unpleasant rash - it began to disappear already on the second day of taking the drug. At the same time, I was pleased that Loratadin itself is much cheaper than its own. expensive analogues. I recommend to anyone who has similar allergic reactions to plants, dust, animal hair, to try treatment with effective Loratadine.

Nikita, 30 years old - Moscow

Review #3

Unexpectedly, Quincke's edema developed very sharply and quickly. The face was swollen to the point of horror and very reddened. It was simply impossible to look at yourself! Before that, I had never suffered from any allergies. I think that my allergy developed from some vegetables stuffed with nitrates and dyes.

After all, what sellers just don’t add to vegetables now to improve appearance products. I just ate a salad of beautiful fresh tomatoes and cucumbers the day before. I bought vegetables in the market, from a private person, and this is the result. But Quincke's edema is an edema of fatty subcutaneous tissue and is quite dangerous. Her face was so swollen that she did not know how to get an appointment with a doctor.

I called the usual district physician to the house, who told me a disappointing diagnosis. Loratadin, prescribed by the doctor, helped me tone the tissues of my face and blood vessels. He very quickly eliminated the rapid development of edema, removed the terrible redness and itching. My face is finally back to the way it was before the allergy.

Loratadine is an excellent drug that is affordable for absolutely everyone! I took it for only four days and during this time I completely returned to normal. The disease is gone. Now I am wary of beautiful vegetables and fruits in the market. I think that I need to start my own garden and grow vegetables on my own - my own health and the health of children is more important!

Raisa, 28 years old - Novosibirsk

Review #4

I often use Loratadine for allergic manifestations in my five-year-old child. Allergies are especially annoying if the son takes some kind of medication, various antibiotics for colds and flu. Immediately a rash appears on the body in the form of small red dots, similar to hives.

The pediatrician told us that when taking various medications, the child should be given antihistamines to prevent further development of an allergy to medications. She advised me to take Diazolin or Loratadin in syrup.

Diazolin seemed too weak in effect, but the syrup perfectly removed the reddish rash on the back. We give our son two teaspoons of syrup a day. No side effects were observed. The child tolerates this drug very well. I recommend to anyone who has small allergic children to treat them with Loratadine.

Svetlana, 26 years old - St. Petersburg

The prevalence of allergic reactions prompts pharmaceutical companies develop the latest effective means to fight this disease. One of the safest means used in clinical practice, is Loratadin tablets and syrup.

Description of the drug

The drug can be presented in the following form:

• Tablets are white or almost white in color, the shape is flat-cylindrical, there is a chamfer.
• Syrup - a liquid without color or with a yellowish tint, has a specific apricot odor.

Specialists classify allergic reactions into four types, each of which requires the development of its own treatment plan.

Pharmacokinetics and pharmacodynamics:

• After oral administration medication in the given therapeutic doses there is rapid absorption in the digestive tract.
• The drug shows complete metabolism.
• An hour later, one can expect the onset of the peak concentration of "Loratadine" in the blood, relative to the main active metabolite, the time increases to 2.5 hours.
• In the case of simultaneous intake of "Loratadine" and food, the bioavailability increases to 40%.
• Revealed a high binding to blood proteins, equal to 98%.
• The elimination half-life lasts up to 8 hours.
• Approximately 80% of the substance is exported with excrement within 10 days.

Pharmacology

The medicinal effect of a pharmacological agent can be described as follows:

• The drug belongs to the second generation of histamine receptor blockers.
• The active ingredient has a pronounced anti-allergic effect.
• The drug relieves itching, has an anti-exudative effect.
• "Loratadin" reduces the permeability of large and small vessels, blocks the development of edema.
• The pronounced contractile activity of smooth muscles decreases, which is initiated by the action of histamine.

Compound

The composition of the antiallergic agent is indicated in the tabular data.

Allergy

can bring not only physical, but also moral discomfort, significantly worsening the quality of life.

Release form, average price:

• "Loratadin", tablet form, cardboard packs with instructions in the attachment, foil blisters. The cost of packing the drug No. 10 is 56 rubles.
• "Loratadin", syrup, cardboard packs with instructions in the attachment, polyethylene bottles. The cost of the drug, with a volume of 100 ml is 112 rubles.

Terms of pharmacy release, storage rules, expiration date:

• Non-prescription dispensing from pharmacies is provided.
• Storage must be provided in special conditions: temperature norm - up to 25 degrees, moderate humidity, isolation from sunlight. The drug should not be available to children.
• The drug retains stable pharmacological characteristics for two years.

Interaction with other medicines

• A mutual change in the concentration of drugs in the blood plasma is observed when joint admission Loratodina with Fluoxetine, Cimetidine, Ketoconazole, Quinidine, Erythromycin.
• The effectiveness of the antiallergic agent is reduced against the background of a one-time intake of ethanol, tricyclic antidepressants, barbiturates, phenytoin.

Indications. Contraindications. Overdose

The drug is used strictly according to indications:

• Rhinitis of allergic origin, in seasonal and chronic form. A condition characterized by the development of inflammation. The disease covers the nasal mucosa.
• Conjunctivitis is an inflammation that affects the mucous membrane of the eyeball.
• Pollinosis is a seasonal disease caused by flowering plants.
• Urticaria, including in idiopathic form.
• Quincke's edema is a gross swelling of the skin that develops in an acute form.
• Dermatosis, accompanied by severe itching.
• Reactions that are commonly referred to as pseudo-allergic.
• Negative reaction to insect bites.

Contraindications

• High sensitivity to the components of the product.
• With caution - in persons with severe hepatic insufficiency.

Allergic rashes localized on the skin are formed after direct contact with an irritant. Ignoring such symptoms leads to the development of extremely negative consequences, up to anaphylactic shock and lethal outcome.

Reception and dosage

Reception and dosage medication must comply with the following rules:

• The drug is synthesized for oral administration.
• The pill is swallowed orally, without chewing, accompanied by moderate amount liquids.
• One tablet is taken once a day if the patient is older age group and crossed the six-year age limit.
• It is strongly recommended to start therapy at 10 mg every other day when severe liver failure. Subsequently, dose adjustment is possible, depending on the course of treatment.
• Duration therapeutic measures determined on an individual basis, but does not exceed six months.
• Clinical experience with the use of "Loratadine" in the treatment of urticaria is limited to a four-month period.
• Elderly patients do not need to recalculate doses.
• If another dosage form is used - syrup - patients need to take 10 mg of the drug 1r / day. Course reception lasts from 5 to 10 days.

Overdose

In the case of a systematic excess of the dose of the drug, develop classic symptoms overdose:

• Pain localized in the abdomen.
• Skin manifestations - itching, urticaria, rash.
• Nausea, vomiting.
• Headache, dizziness.

When an overdose is detected, it is implemented symptomatic therapy, in severe forms gastric lavage is indicated, in the lungs - the intake of enterosorbents.

Side effects and special instructions

Side effects:

• Headaches, up to the onset of migraine attacks.
• Excessive fatigue.
• Dryness that occurs on the oral mucosa.
• Vomiting, severe nausea.
• Drowsiness.
• Gastritis - dystrophic and inflammatory lesions of the gastric mucosa.

Allergies resulting from flowering plants spoil the lives of thousands of people. This disease is called pollinosis. Doctors also call it hay fever.

• Allergic manifestations, usually in the form of a rash.
• Anaphylaxis - acute allergic manifestation immediate type.
• Alopecia - pathological loss hair.
• Impaired hepatic function.
• Tachycardia, palpitations.
• In childhood, sedation, excessive nervous excitability, headaches are observed.

special instructions

The safe use of an antiallergic agent is possible, taking into account additional instructions:

• Revision of the dosing regimen is required for patients with impaired liver and kidney function.
• The use of "Loratodin" does not exclude the development of seizures, which applies to patients predisposed to such reactions.
• The drug is not used for treatment during pregnancy or breastfeeding.

For kids

In the pediatric field, the drug is used as follows:

• Syrup. Adolescents over 12 years old. - 10 ml once a day, children in the group from 2 to 12 liters - 5 ml once a day.
• The tablet form is prescribed for patients older than 12 years. 10 mg (one pill) daily.

Analogues

Antiallergic drugs with a similar spectrum of action are listed below.

"Clarices"

The drug can effectively stop attacks of seasonal and chronic allergies.

• The drug causes fewer side effects.
• The tool is not used to treat people suffering from phenylketonuria.

The cost of the drug is 59 rubles.

"Lomilan"

Preventive and therapeutic antiallergic drug. The dosage is calculated according to individual indications.

Modern pharmacological preparations allow to stabilize a person's condition in a short time.

Distinctive characteristics:

• The form of the drug in the form of a suspension was synthesized.
• Treatment with the drug is contraindicated in lactose intolerance.

The cost of funds is 132 rubles.

"Erolyn"

The drug has an anti-exudative effect, relieves itching and inflammatory reactions. The dosage is developed individually by the attending physician.

Distinctive characteristics:

• According to indications, it is possible to prescribe medication during pregnancy.
• The drug contains lactose, which should be taken into account in patients with a certain range of diseases.

The cost of funds is 137 rubles.

Many parents experience an allergic reaction in a child. It can develop in response to inhaling plant pollen, taking any medication, eating food, using detergent or for some other reason. In the fight against swelling, rash, cough, sore throat and other allergy symptoms, antihistamines are most often used. One of them is Loratadin. If it was prescribed to a child, then parents should know how it acts on children's body and how it is received.

Release form

Loratadine is produced by many pharmacological companies and a prefix indicating the manufacturer may be present in its name. For example, Loratadin Teva is produced by the Israeli company Teva, Loratatin-Akrikhin is a product of the Russian chemical-pharmaceutical plant Akrikhin, and Loratadin-Hemofarm is produced in Serbia by the Hemofarm concern. Moreover, all such drugs have the same active substance, the same indications, possible side effects and contraindications.

In pharmacies, Loratadin is presented:

• syrup. It is a light yellow, sweet tasting, clear thickish solution with a fruity odor. The volume of syrup in one bottle can be 50, 100 or 120 ml. A glass or a measuring spoon is attached to the bottle in order to accurately measure such a sweet medicine in the dose prescribed by the doctor.
• Tablets. Usually these are small round tablets white, which have a risk. Most often they are available in a package of 10 pieces, but one box can contain from 7 to 90 tablets.
• Effervescent tablets. In this form, Loratadin-Hemofarm is produced. Such tablets are sold in plastic tubes of 10 pieces, and one box contains 1-2 tubes.

Compound

All forms of the drug contain the same active substance, which is also called loratadine. In 5 ml of syrup, it is represented by a dosage of 5 mg, and one tablet contains 10 mg. The content of loratadine in one effervescent tablet is also 10 mg.

The composition of the syrup, in addition to the active ingredient, includes citric acid, propylene glycol, water, flavor, ethanol, sodium benzoate, glycerin and other substances. Loratadine tablets additionally contain microcrystalline cellulose, calcium stearate, corn starch, lactose monohydrate and other components that provide such a drug with a solid form.

Auxiliary ingredients of tablets from which they are made fizzy drink, are lactose, citric acid, sodium carbonate and bicarbonate, as well as macrogol 6000, povidone, silicon dioxide (colloidal) and polysorbate 80. Thanks to these compounds, the drug keeps its shape while in the tube, but quickly dissolves in water.

Operating principle

Loratadine blocks H1 receptors sensitive to histamine, which prevents it from being released from mast cells this biologically active compound and other substances. This action prevents the development of an allergic reaction or relieves the symptoms of an allergy if they have already appeared. Taking Loratadine reduces the severity of itching, and also has an anti-exudative effect and reduces the permeability of small vessels, due to which allergic edema decreases. In addition, the drug has the ability to relax spasmodic smooth muscles.

The onset of the therapeutic effect of Loratadine can be seen within half an hour after application. Maximum effect develops by 8-12 hours after ingestion and lasts up to 24 hours. Such a long-term effect on the body is associated with the formation in the process metabolic changes Loratadine is a substance called desloratadine, which also has antihistamine activity. In this case, the drug does not pass through the blood-brain barrier, therefore it is unable to depress the central nervous system and be addictive.

Indications

Loratadine can be prescribed to a child:

• With allergic rhinitis;
• with pollinosis;
• with angioedema;
• with urticaria;
• with an allergic reaction to an insect bite;
• with inflammation of the skin, which is manifested by itching, as well as with chickenpox;
• with acute conjunctivitis;
• with atopic dermatitis;
• with false allergic reactions.

In addition, the drug is often prescribed for adenoiditis, pharyngitis, nasopharyngitis and similar diseases to reduce swelling of the mucous membrane.

At what age is it allowed to take?

Loradatin is not indicated for children under 2 years of age. A child who is 2 years old can be given any of the medication options. At the same time, it is more convenient for the treatment of young children under 6 years of age. liquid form(syrup), but if a younger child (at 4 or 5 years old) has no problems swallowing a solid medicine, then a tablet preparation can also be given to him.

Contraindications

Loratadine should not be given not only at the age of less than 2 years, but also in case of intolerance to any of the components of the selected form of the drug. The medicine has no other contraindications for children, and for adults the remedy is not prescribed during lactation and during pregnancy.

Side effects

Reception of Loratadine can cause a decrease in appetite, changes in stool, nervous excitement, dry mouth, nausea, drowsiness, sweating, hives, headaches and other negative symptoms. If they appear, the medicine is immediately canceled.

Instructions for use and dosage

The drug is given to children once a day, determining the dosage by the age of the small patient, as well as by his weight:

• If the child is under 6 years old or older but weighs less than 30 kg, then single dose the drug is 5 mg. It is contained in 5 ml of syrup or half of Loratadine tablets. Effervescent tablets are not prescribed for children under six years of age and weighing less than 30 kg;
• If the weight of a small patient is above 30 kg and his age is 6 years or more, then a single dosage for him will be 10 mg of loratadine. The patient can receive such a dose from 2 scoops of syrup (10 ml), one tablet or one effervescent tablet.

To prepare a drink from an effervescent tablet, you need to throw it in 200 ml of water, and then drink the drug. Swallowing, sucking or chewing Loratadine in this form is not recommended.

Overdose

If you give the child the drug in higher dose than prescribed by the doctor, this will lead to drowsiness and headaches, as well as to tachycardia and motor neurological disorders. Having noticed an overdose, you should immediately induce vomiting in a small patient and give the baby a sorbent. If the child's condition worsens, it is necessary to show it to the doctor.

Interaction with other drugs

Loratadine is compatible with many medications, therefore it is often used in the treatment of infectious diseases, high acetone and other problems in which it is necessary to prevent or eliminate an allergic reaction. In this case, the medicine should not be given together with rifampicin, barbiturates, erythromycin and some other drugs indicated in the annotation for tablets or syrup.

Terms of sale

All forms of Loratadine are over-the-counter drugs, therefore they are freely sold in pharmacies. The price of the drug depends on the manufacturer, and on the dosage form, and on the size of the package. For example, 10 tablets of Loratadin cost about 13-15 rubles, and a bottle of Loratadin-Akrikhin syrup costs about 150 rubles.

Storage conditions

Keep any of the forms of Loratadine at home should be at room temperature in a place hidden from small children, dry and inaccessible to sunlight. The shelf life of the drug is different different manufacturers, so it should be clarified (the data is available on the box of the purchased product). Often, syrup is stored for 3-4 years from the date of manufacture, and tablets - 3-5 years.

Reviews

In most cases, parents are satisfied with the treatment of children with Loratadine and note it. high efficiency with allergic reactions. Moms most often choose syrup and praise this form for its pleasant taste and ease of use. The advantages of the drug in tablets include a small size, the need to take only once a day and low cost.

Analogues

A full replacement for Loratadine can be drugs that contain the same active ingredient, for example:

• Lomilan.
• LoraGEKSAL.
• Claricens.
• Claridol.
• Erolyn.
• Clarotadine.

Loratadine for children is used for manifestations of seasonal hay fever. It is used as a classic histamine receptor antagonist. By blocking the reception of histamines released from it, it stops allergic reactions. Effective against itching, urticaria, rhinitis, conjunctivitis, allergic bronchitis. As the instructions say, the active ingredient is an insoluble white powder, which contains tablets and syrup.

Loratadin tablets and syrup, as the instructions say, can be used for:

• Seasonal and year-round acute hay fever;
• Atopic conjunctivitis;
• Chronic rhinitis, and pharyngitis;
• Allergic asthma;
• atopic dermatitis;
• Itching of the skin and mucous membranes of the nasopharynx;
• Urticaria;
• Allergies of unspecified etymology.

hay fever

can be considered the scourge of the 21st century. According to WHO, compared with the 20th century, the frequency of allergic reactions, which manifest themselves depending on the season, has become several times higher. Symptoms of pollinosis include inflammation of the mucous membranes of the nasopharynx, eyes, throat, itching and urticaria.

Allergy is the result of contact with allergens on the mucous membranes, to which the basophils of the body have a negative reaction.

Basophils are cells of the human immune system that are found in almost any tissue. The result of the reaction is the release of histamine - the "inflammatory hormone". The cell captures it with its histamine receptors, which signal the onset of inflammation.

As a result, the cell swells, increasing in size and releases fluid into the extracellular matrix. The affected area swells, redness appears. Nerve receptors are excited, itching appears. All this leads to general symptoms allergies. In acute cases, tissues can increase tenfold. Depending on the location of the lesion, the condition can be completely different.

Conjunctivitis occurs when an allergen gets into the eyes. The tearing of the eye increases, itching appears. The eyelids and tissues adjacent to the eye may swell. Due to constant tearing, temporary visual impairment is possible. Rhinitis is an allergic reaction of the nasal mucosa and nasal choanae to the inhalation of an allergen. Mucus is secreted, the nose itches.

It is possible to block the nasal passages, which in part is protective against the allergen, preventing the allergen from moving further into the body.

Conjunctivitis and rhinitis are the most frequent signs seasonal allergies, developing as a response to plant pollen during the flowering period.

Dermatitis

can be a manifestation not only seasonal, but also permanent. It manifests itself in the form of redness and peeling of the skin. It can be a reaction to food, medicine or animal hair. Pharyngitis can also manifest itself from food or animal hair. Its anatomical essence is the narrowing of the folds of the pharynx, which can lead to coughing, and even to Quincke's edema.

Asthma

Asthma is a consequence of the allergen getting into the bronchi of the lungs. The cells of the bronchus, expanding, occupy all the free space, preventing a person from exhaling. In the absence of primary asthmatic disorders of the bronchus, an allergic reaction will not cause a complete cessation of breathing, but can seriously complicate breathing, cause wheezing and coughing.

Urticaria is also a response to allergens. It is expressed in redness of the skin, which looks like "bites" of nettles. Appear on the back, chest, arms, hips.

Not infrequently, spots are accompanied by itching, pain, a feeling of "fullness" under the skin and elevated temperature spots.

Allergies can also be unidentified - an allergen can occur situationally. Perhaps they may be a certain chemical that has fallen into the environment of a child or a purchased flower. If it is impossible to establish the cause of the allergen, supportive therapy is prescribed.

Forms of the drug

With Loratadine, both syrup and tablets are available. Both forms have the same effect, therefore, if the child has no contraindications to the drug, you can start taking it. Try not to resort to self-medication and, in case of allergies, use drugs only after being prescribed by a doctor and only in the cases indicated by the instructions.

The tablets contain 10 milligrams of the active substance - loratadine, as well as excipients - lactose monohydrate, starch, crystalline microcellulose and stearic acid. Lactose and starch make up the bulk of the shell and the preparation. Cellulose helps the absorption of the drug in the small intestine, and stearic acid normalizes the digestion and absorption of the drug.

Tablets are available in the form of blisters of 10 tablets each. Packages contain 1 or 3 blisters.

The syrup contains 1 milligram of loratadine per 1 milliliter of the drug, as well as in the form excipients propylene glycol, sodium benzoate, citric acid, food grade sorbitol, ethyl alcohol and flavoring.

In this case, be careful about the presence ethyl alcohol, since an additional allergic reaction is possible on it in the child's body.

Dosage

Loratadine syrup can be taken from the age of two. Dose calculation is based on body weight. Included with the syrup is a measuring spoon for 5 milliliters of the drug. Children from one to 6 years old, with a body weight of less than 30 kilograms, should be given 1 spoon once a day. Children from 6 years of age and older, with a body weight of 30 kilograms or more, are given 2 scoops of the drug 1 time per day.

Loratadine tablets should be taken at least 1 hour before meals. Dosage is also calculated based on age and body weight. Children aged from one to 12 years, with a weight of up to 30 kilograms, should be given half a tablet or 5 milligrams of a substance per day, with a weight of more than 30 kilograms - 1 tablet per day. At the same time, attending physicians sometimes advise dividing the intake of the substance into two or three doses.

The maximum allowable and proven dosage per day for syrup and tablets is 10 milligrams. If you do not have the opportunity to consult a doctor, start from this dosage and try not to exceed it in any case.

Side effects

According to clinical trials, the tablets are well tolerated by children and adults. The most common side effects associated with poor tolerance drug.

These include:

• Rash;
• fatigue;
• Increased drowsiness;
• Allergic reactions - itching, swelling, hives;
• Decreased daily diuresis.

If these symptoms appear, stop taking the drug and consult a doctor for advice.

Contraindications

Doctors indicate renal failure as the main contraindication for syrup and tablets. reduce the amount of urine output, which is already not high in this pathology, which can lead to increased intoxication of the body and severe clinical consequences.

In addition, contraindications include:

• Hypersensitivity to the drug loratadine;
• Lactase intolerance;
• Allergic reactions to components.

With increased sensitivity, it is possible to enhance the effect of the drug. Drowsiness increases, urine output worsens. In this case, it is worth trying another antihistamine drug similar in effect, not containing this biologically active substance.

Lactose intolerance is a contraindication to taking the tablet form. Lack of lactase, the enzyme that catalyzes the breakdown of lactose, causes flatulence, stool problems, and in extreme cases, vomiting. Despite the "insignificance" of these side effects, you should stop taking the pills and switch to another drug or syrup.

An allergy is possible not to loratadine itself, but to auxiliary components. In connection with the spread of allergies in the mass, it is worth carefully monitoring the manifestation of the response of the child's body to the drug. There is itching, urticaria, in some cases - rhinitis and conjunctivitis.

In case of acute allergy to the drug, the chance of aneurotic edema increases - Quincke's edema.

Quincke's edema is considered an acute allergic condition that endangers the life of a child. In this case, it is necessary to urgently contact an ambulance and not delay treatment.

The drug is latent to overdose, and when the daily dose of 10 mg of the drug is exceeded, the side effect of the drug increases - drowsiness. As a measure of treatment, the child is vomited and finely ground activated charcoal is given. An overdose leading to a coma has not been registered.

Analog - Suprastin

Loratadin and Suprastin are often compared. Suprastin tablets have a similar effect, the instructions for both drugs do not recommend taking them for up to a year. However, Suprastin has a more specific use and more severe consequences overdose, therefore, in this case, you can lean towards the drug Loratadine.

When deciding to take Suprastin or Loratadin syrup, you should be aware that the instructions do not provide comprehensive information.

Suprastin can only be taken when conducting an allergic test for the drug, since children under one year old may have an adverse reaction to Suprastin.

The price of Suprastin is more than the price of Loratadine, however, before giving children up to a year, you should consult a doctor.

Price

On average, for a pack of 10 tablets, you will give from 20 to 60 rubles. This is an extremely small price for an antihistamine, and only gives it an additional advantage, in comparison with other antihistamines - Suprastin or. For syrup, the price ranges from 120 to 130 rubles. Loratadine is available from pharmacies and does not require a prescription to purchase.

Compound tablets: loratadine (10 mg / tab.), As well as MCC, potato starch, lactose monohydrate and stearic acid.

Part syrup the active substance is included in a concentration of 1 mg / ml, as well as anhydrous citric acid, refined sugar, sodium benzoate, glycerin, propylene glycol, food flavoring "Apricot 059", purified water.

Release form

Loratadine has two dosage forms:

• tablets 10 mg (No. 10 * 1 or No. 10 * 3);
• syrup 1 mg/ml (bottles or containers 50 and 100 ml).

pharmachologic effect

H1-antihistamine.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Loratadine is antiallergic agent II generation. H1-type histamine receptor blocker. It has a longer effect in comparison with the first generation drugs. Does not affect the central nervous system, the sinoatrial node and the state of the cardiovascular system, does not have a sedative and anticholinergic effect.

Shows a comprehensive antipruritic , anti-exudative and antiallergic activity. Reduces the permeability of capillary walls, prevents the development of tissue edema and relieves muscle spasm.

In patients taking Loratadine for a long time, there were no significant changes in the ECG, as well as changes in physical and laboratory parameters.

Pharmacokinetics

After taking the tablet / syrup, the active substance is determined in the blood after 15-20 minutes. The effect appears within 1-3 hours, reaching a maximum 8-12 hours after taking the syrup / tablet, and persists for another 12-16 hours. The total duration of action is 24 hours.

Contacts with plasma proteins for 97%. It is characterized by a pronounced “first passage” metabolism. It does not penetrate the BBB, but passes into breast milk.

It is almost completely biotransformed in the liver with the participation of CYP3A4 and CYP2D6 isoenzymes (the latter is less active) with the formation desloratadine (descarboethoxyloratadine), which is the pharmacologically active metabolite of loratadine.

Css (desired plasma concentration at steady state) is achieved on the fifth day of the drug.

T1 / 2 loratadine - from 3 to 20 hours in young people and from 6.7 to 37 in the elderly. For desloratadine these figures are 8.8-92 and 11-38 hours, respectively.

At alcohol disease liver pharmacokinetic parameters for Loratadine are doubled, while the pharmacokinetic profile does not change in comparison with patients with intact liver.

The substance and its metabolic products are excreted in the urine and faeces.

In patients with chronic renal failure, the values ​​of pharmacokinetic parameters do not change in comparison with patients with healthy kidneys. Holding does not change the pharmacokinetic profile of the drug.

Indications for the use of Loratadine: why these tablets and syrup?

What is Loratadine tablets for?

Loratadine tablets are used for symptomatic treatment allergic diseases . The drug is effective for (year-round or seasonal) (acute or chronic) , , pseudo-allergic reactions on histamine liberators, chronic eczema , contact dermatitis .

Indications for use Loratadine syrup

The syrup is intended for use in pediatric practice. In particular, it is used to treat children from 24 months to 12 years old weighing up to 30 kg.

The drug quickly and effectively relieves the symptoms of CCI ( chronic idiopathic urticaria ), allergic rhinitis (including "hay fever"), allergic conjunctivitis , allergic pruritic dermatoses (in combination with other drugs), as well as provoked by the release histamine pseudo-allergic reactions and reactions to insect bites.

Contraindications

General contraindications:

• intolerance to the components of tablets / syrup;
• pregnancy;
• lactation;
• age up to 2 years.

For children weighing less than 30 kg, syrup is the preferred dosage form.

Loratadine should be used with caution in patients with severe liver pathologies .

Side effects

Adverse events on the background of the use of the drug develop with the same frequency as with the use of placebo.

The most common side effects are:

• headache;
• drowsiness;
• dizziness;
• fatigue;
• dry mouth;
• allergic rash ;
• palpitations ;
• tachycardia ;
• nausea and / or vomiting;
• gastritis ;
• increased appetite;
• pathological changes in liver function;
• hypersensitivity reactions (including anaphylaxis ).

In children aged 24 months to 12 years after taking the syrup / tablets, nervousness, agitation, headache, fatigue were noted.

Application instruction of Loratadin

Tablets Loratadin: instructions for use

For patients over 12 years of age, the drug is prescribed at a dose of 10 mg / day.

Patients with impaired liver function treatment should begin with a dose of 10 mg / day. every other day or with 5 mg / day. daily.

At kidney failure , as well as the elderly, the drug is used in the standard mode. There is no need for dose adjustment.

The same recommendations are given in the instructions for use. Loratadina Teva , Loratadine-Stoma , Loratadina-Verte and Loratadina-Stada . The only differences are age restrictions for drugs manufactured by Teva Pharmaceutical Industries and STADA. They are not prescribed for children under 3 years of age.

The duration of the course is determined by the doctor depending on the characteristics of the clinical situation.

At strong manifestation allergies other drugs may be used as an adjunct to loratadine (eg, corticosteroid ointment or corticosteroid drops , immunostimulants , tear substitutes and other means).

Instructions for syrup

For patients over 12 years of age, the drug is prescribed to take 1 r. / Day. two teaspoons per dose (10 mg). Patients with liver dysfunction the indicated dose should be taken every other day.

Instructions for use for children of the tablet form of the drug.

Children over 12 months old tablets from a allergies prescribed only on condition that their body weight exceeds 30 kg. The optimal dose for children is 5 mg / day.

Instructions for syrup for children

Children over 24 months old, provided that their body weight is more than 30 kg, are given two teaspoons, and children weighing less than 30 kg - one teaspoon of syrup per day.

The duration of the course is usually 5 to 10 days.

Overdose

Against the background of an overdose, the frequency of development increases anticholinergic symptoms : headache, , drowsiness.

In case of an overdose, the patient is shown gastric lavage, application enterosorbents supportive and symptomatic therapy.

Interaction

Simultaneous use with , provokes an increase in the plasma concentration of Loratadine, which, however, does not manifest itself clinically, including on the ECG. The effect is caused by a violation of the metabolism of the drug, probably due to the suppression of the activity of the CYP3A4 isoenzyme of the cytochrome P-450 system by the indicated means.

An increase in the plasma concentration of loratadine can also be facilitated by the simultaneous use of tablets / syrup with protease inhibitors ( Ritonavir , Amprenavir , Nelfinavir ).

The possibility of developing dose-dependent sedative effect with simultaneous use of the drug with other H1-type histamine receptor blockers, opioid receptor agonists, benzodiazepines , tricyclic antidepressants , antipsychotics , sleeping pills and sedatives .

Terms of sale

Without recipe.

Storage conditions

Keep out of the reach of children at temperatures below 25ºС.

Best before date

Two years.

special instructions

Loratadine in some cases can provoke dose-dependent sedative effect .

The drug has no (or little effect) on the ability to drive vehicles or other mechanisms. However, the patient should be informed that one of the possible side effects of Loratadine is drowsiness.

If it is necessary to carry out skin test on the allergens the drug should be discontinued at least 7 days before the test.

The composition of the tablets includes lactose, and therefore they are contraindicated in persons with rare forms galactose intolerance , lactase deficiency or glucose/galactose malabsorption syndrome .

When prescribing syrup to patients with it must be borne in mind that refined sugar is included in its composition.

Loratadin's analogs

Coincidence in the ATX code of the 4th level:

Loratadin's analogs on structure (synonyms): Loratadin-Teva , Loratadin-Verte , Loratadine Stoma , Loratadin Stada , Loratadine-OBL , Alerprive , Clallergin , Clargotil , clarifer , , , Lomilan Solo , , Lotharen , Erolyn .

Similar drugs with a similar mechanism of action: Allerfeks , , Dimebon , Dinox , , Nalorius , , , , , Desloratadine .

Which is better - Loratadine or Claritin?

main component Claritina is loratadine (moreover, the substance is contained in tablets and syrup in the same concentration as in Loratadine).

Being pharmaceutically equivalent, the drugs differ significantly in price. Produced by Schering-Plough, Claritin is an order of magnitude more expensive than its Russian counterpart.

Loratadine and Desloratadine, differences

Desloratadine is the primary metabolite of Loratadine, but belongs to the 3rd generation antihistamines .

Their fundamental difference from their predecessors is that they are unable to influence the QT interval.

2nd generation drugs can block the potassium channels of the heart muscle, which is associated with the development arrhythmias and prolongation of the QT interval. This side effect is more likely to occur:

• when combined with loratadine macrolides , antimycotics , antidepressants ;
• when using the drug with grapefruit juice;
• in patients with severe dysfunction liver .

Comparative studies of Loratadine and Desloratadine (in comparable doses) did not show differences between their toxicity indicators (both quantitative and qualitative).

Which is better: Cetirizine or Loratadine?

- this is antihistamine second generation, highly selective H1-type peripheral histamine receptor antagonist. The properties common to all second-generation drugs are:

• rapid onset of effect;
• minimal expression anticholinergic and sedative effects when used in therapeutic doses;
• duration of action;
• absence tachyphylaxis against the background of long-term use.

The drug is characterized by the ability to penetrate the skin well, due to which it effectively eliminates skin manifestations of allergies .

In the course of post-marketing studies against the background of the use of the substance cetirizine rare but potentially severe side effects: hemolytic anemia , anaphylaxis , aggressive reaction, convulsions, cholestasis , hallucinations, glomerulonephritis , suicidal tendencies and suicide, hepatitis , severe hypotension , orofacial dyskinesia , dead birth fetus, thrombocytopenia .

Cetrin or Loratadin - which is better?

- this is a more expensive analogue cetirizine . Its basis is the same active substance - cetirizine . The drug is preferred for stopping skin manifestations allergies .

Loratadine and alcohol

The drug does not potentiate the inhibitory effect of alcohol on the central nervous system.

Loratadine during pregnancy and lactation

There are very few data on the use of the drug during pregnancy. Animal studies have not identified a reproductive toxicity hazard. However, the manufacturer recommends avoiding the drug in pregnant women.

Physico-chemical data indicate that the active substance of the drug and its metabolites are excreted in breast milk. Since potential risks to the baby cannot be ruled out in this regard, Loratadine is not recommended for use while breastfeeding.

Reviews about Loratadine

Loratadine is one of the most popular means from allergies among 2nd generation drugs. It exhibits significantly greater antihistamine activity in comparison with some analogues, which is explained by more high strength binding to peripheral H1-type receptors.

Reviews of doctors confirm the fact that Loratadin is deprived sedative effect does not enhance the effect ethanol , does not have cardiotoxic effect , almost does not interact with other drugs and is not addictive.

According to patients, allergy syrup and pills Loratadine is an effective and affordable remedy that acts for a long time and is very mild. In addition, it is convenient to take (both adults and young children).

It should be noted that reviews Loratadine Teva practically indistinguishable from reviews of cheaper ones Russian drugs, which are produced under the same trade name.

How much does Loratadine cost?

The price of Loratadine depends on which company this drug is produced by. So, for example, the price of Loratadine in tablets from OAO Tatkhimfarmpreparaty is 27-35 rubles. for packing No. 10, and 7 tablets of Loratadin-Teva can be bought for an average of 150 rubles. The price of syrup is 125-150 rubles.

The price of Loratadine in Ukraine is from 5.8 UAH. This is how much Loratadin Stoma produced in Kharkov costs. The price of the drug from the pharmaceutical company Darnitsa is slightly higher - approximately 9-11 UAH. The average price of syrup is 28 UAH.

Loratadine is not available in the form of an ointment, but you can find a nasal ointment “with loratadine” in pharmacies. The drug is used to treat influenza and SARS, including in patients with allergic rhinitis. You can buy it for an average of 200 rubles.

• Internet pharmacies in Russia Russia
• Internet pharmacies in Ukraine Ukraine

WER.RU

Grippferon with loratadine ointment 5 g Firn M

Desloratadine tablets 5 mg 10 pcs. Vertex

Loratadine tablets 10 mg 30 pcs. Vertex

Loratadin-Teva tablets 10 mg 7 pcs. Teva

Loratadine tablets 10 mg 10 pcs. Vertex

Europharm * 4% discount with promo code medical11

Loratadin-teva 10 mg 7 tab.Teva Private Co. Ltd. Pharmaceutical Plant

In this article, you can read the instructions for using the drug Loratadine. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Loratadine in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Loratadine, if available structural analogues. Use to treat allergies in adults, children, and pregnancy and lactation. The action of the drug with alcohol.

Loratadine- a blocker of histamine H1 receptors (long-acting). Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antipruritic, antiexudative action. Reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasms of smooth muscles.

The antiallergic effect develops within 30 minutes, reaches a maximum after 8-12 hours and lasts 24 hours. The active metabolite desloratadine significantly contributes to the duration of action. It does not affect the central nervous system and is not addictive (because it does not penetrate the blood-brain barrier (BBB)).

Pharmacokinetics

Rapidly and completely absorbed in the gastrointestinal tract. It is metabolized in the liver to form the active metabolite descarbose oxyloratadine. Does not penetrate the BBB. It is excreted by the kidneys and with bile.

Indications

• allergic rhinitis (seasonal and year-round);
• conjunctivitis;
• hay fever;
• urticaria (including chronic idiopathic);
• angioedema;
• itchy dermatoses;
• pseudo-allergic reactions;
• allergic reactions to insect bites.

Release forms

Tablets 10 mg.

Effervescent tablets 10 mg.

Syrup 5 mg/ml.

Instructions for use and dosage

Inside adults and children over 12 years old, as well as with a body weight of more than 30 kg - 10 mg 1 time per day.

Children from 2 to 12 years old with a body weight of less than 30 kg - 5 mg 1 time per day.

Side effect

• dry mouth;
• taste change;
• anorexia;
• constipation or diarrhea;
• dyspepsia;
• flatulence;
• increased appetite;
• stomatitis;
• nausea, vomiting;
• anxiety;
• excitement (in children);
• asthenia;
• drowsiness;
• blepharospasm;
• paresthesia;
• tremor;
• depression;
• increased fatigue;
• dermatitis;
• alopecia;
• change in the color of urine;
• painful urge to urinate;
• dysmenorrhea;
• menorrhagia;
• weight gain;
• sweating;
• thirst;
• cramps of the calf muscles;
• cough;
• bronchosiasm;
• dryness of the nasal mucosa;
• visual impairment;
• conjunctivitis;
• pain in the eyes and ears;
• decrease or increase in blood pressure;
• heartbeat;
• angioedema;
• anaphylaxis;
• hives;
• rash;
• photosensitivity;
• backache;
• chest pain;
• fever;
• chills;
• pain in the mammary glands.

Contraindications

• pregnancy;
• lactation period;
• children's age up to 2 years;
• increased sensitivity.

Use during pregnancy and lactation

Contraindicated.

Use in children

For kids younger age and adults with difficulty in swallowing, the use of syrup is recommended.

Children 2 to 6 years of age (weighing less than 30 kg): 5 mg (1 scoop (5 ml) of syrup) once daily.

Children over 6 years of age (weighing more than 30 kg) and adults: 10 mg (2 scoops (10 ml) of syrup, or 1 tablet, or 1 effervescent tablet) 1 time per day.

Contraindicated in children under 2 years of age.

special instructions

During the period of treatment, it is necessary to refrain from potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions.

drug interaction

Erythromycin, cimetidine, ketoconazole increase the concentration of loratadine in blood plasma without causing clinical manifestations without affecting the ECG.

Microsomal oxidation inducers (phenytoin, ethanol (alcohol), barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness of loratadine.

Analogues of the drug Loratadine

Structural analogues for the active substance:

• Alerprive;
• Vero-Loratadine;
• Clallergin;
• Clargotil;
• Claridol;
• Claricens;
• Claritin;
• Clarifer;
• Clarotadine;
• Lomilan;
• Lomilan Solo;
• LoraGeksal;
• Loratadine 10-SL;
• Loratadine-OBL;
• Loratadin-Verte;
• Loratadin-Teva;
• Loratadin-Hemofarm;
• Loratadin-Stada;
• Lotharen;
• Tyrlor;
• Erolyn.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.