ACC - instructions for use. How to drink ACC effervescent tablets, powder or cough syrup for adults and children

Most diseases are always accompanied by a cough, so it is understandable that there is a desire to get rid of it faster. The range of anti-influenza and expectorants is wide. How to make the right choice? Not every medication is suitable for the treatment of dry or wet cough. So ACC can not always be used.

ACC - indications for use

Ass medicine is a mucolytic, expectorant and detoxifying agent, prescribed for severe coughs in children and adults. This drug is able not only to dilute sputum, but also to effectively remove it from the lungs and bronchi, relieve inflammation, and improve the functioning of the secretory motor functions of the body. The ACC instruction states that it can be used in the presence of the following deviations in the state of health:

• acute or chronic bronchiolitis and bronchitis;
• sinusitis;
• asthma;
• pneumonia;
• pulmonary eczema;
• tuberculosis;
• otitis media;
• cold.

Even this is not all the possibilities of the ACC. Due to its medicinal properties, the drug is often used in cystic fibrosis - hereditary disease caused by a gene mutation. In addition, it is often prescribed for the treatment of mild or prolonged inflammatory processes of the nasopharynx: tracheitis, acute rhinitis, rhinopharyngitis, sinusitis, which are accompanied by the accumulation of a large amount of purulent mucus.

What kind of cough is ACC prescribed for?

If the house already has a package of the remedy, then before going to the pharmacy, you can independently study what kind of cough they drink ACC. However, complex medical terms and phrases will not be clear to everyone. Doctors recommend taking the drug with a wet productive cough - when excess viscous or too thick sputum accumulates in the bronchi.

ACC - at what age can children be given

Many young mothers ask: is it possible and from what age to give ACC to children? To which experienced pediatricians confidently answer: it is not only possible, but necessary. The main thing is to do it right:

• A child from 2 years old to 6 years old can only be given ACC 100 mg, which is available as a powder.
• Starting from the age of 7, treatment with ACC 200 mg is allowed. This medicine can be found in granules.
• For children 14 years of age and older, ACC 600 is available. Unlike other drugs, this type of medication is valid for 24 hours.
• As a syrup, medicine is allowed to be given to infants, but only under the supervision of a pediatrician.

How to use ACC

For convenience, many pharmaceutical companies began to produce the drug in several forms: granules, for example, with orange flavor, instant tablets, syrup. Each form has its own doses and framework for how to take ACC:

• It is extremely rare that the solution is prescribed for inhalation. If the nebulizer used for the procedure is equipped with a distribution valve, then 6 ml of a 10% powder solution should be used. If there is no such supplement, doctors recommend taking a 20% solution at the rate of 2-5 ml per 1 liter of water.
• With bronchoscopy, severe rhinitis, sinusitis, the use of ACC intratracheally is allowed. To clean the bronchi and nasal sinuses, a 5-10% solution is used. The diluted liquid must be instilled into the nose and ears up to 300 mg per day.
• With the parenteral method of application, ACC is administered intramuscularly or intravenously. In the latter case, the ampoule must be diluted with sodium chloride or dextrose in proportions of 1 to 1.

ACC-long - instructions for use

ACC tool marked long is different from conventional tablets or powder in that the effect of exposure to it lasts not 5-7 hours, but the whole day. The medicine is produced in the form of large effervescent tablets and is intended for oral administration 1 tablet 1 time / day, in the absence of other doctor's recommendations. Additionally, along with the medicine, it is necessary to drink up to one and a half liters of liquid, which enhances the mucolytic effect.

How to breed ACC long:

1. Pour into a glass of clean chilled boiled water, put a tablet on the bottom.
2. Wait for the effervescent effect to pass and the capsule to completely dissolve.
3. Drink the solution immediately after dissolution.
4. Sometimes, before drinking ACC, the diluted drink can be left for several hours.

ACC powder - instructions for use

ACC powder is used in the following doses:

• adolescents over 14 years of age and adults are prescribed up to 600 mg of acetylcysteine, the intake is divided into 1-3 approaches;
• a child under 14 years of age is recommended to give the same dose of the drug, but divided into several doses per day;
• babies under 6 years old can be given 200-400 mg of powder per day.

ACC powder for both adults and children should be drunk after meals, and the composition from the bag must be properly prepared. In what water to dissolve ACC depends on your preferences, but remember: best result will be achieved if the medicine is diluted with half a glass hot water. However, orange-flavored baby granules can be dissolved in lukewarm, boiled water.

Effervescent tablets ACC - instructions for use

Effervescent tablets of acetylcysteine ​​are diluted with water according to the same system as regular powder. The dose of the drug, in the absence of other doctor's recommendations, is:

• with colds infectious diseases, occurring in a mild form, for adults - 1 tablet of ACC 200 2-3 times a day, for 5-7 days;
• with chronic cough, bronchitis or cystic fibrosis, the drug is drunk for a longer period, and its dose for adults is 2 capsules of ACC 100 three times a day.

ACC syrup for children - instructions

Sweet ACC syrup is prescribed for children from the age of two and older, in the diagnosis of colds mild form or chronic bronchitis. The medicine is taken orally, for 5 days, immediately after eating. The dosage of the syrup is chosen by the attending physician. If no recommendations have been received from the pediatrician, then the ACC will be the guide - the official instructions for use from the manufacturer, which says that you can take the medicine:

• adolescents 10 ml 3 times / day;
• if the child is from 6 to 14 years old, then 5 ml 3 times / day;
• for babies 5 years old, the dose of the drug is 5 ml 2 times / day.

Remove the children's syrup from the vial using a measuring syringe. The device comes with medication. The instructions for using the syringe are as follows:

1. Press on the vial cap, turn it clockwise until it clicks.
2. Remove the cap from the syringe, insert the hole into the neck and press the syringe until it stops.
3. Turn the vial upside down, pull the syringe handle towards you, measuring required dose syrup.
4. If bubbles appear inside the syringe, lower the plunger slightly.
5. Slowly pour the syrup into the child's mouth and let the child swallow the medicine. While taking the drug, children should stand or sit.
6. After use, the syringe must be washed without soap.

Analogue of ACC

If you are looking for a cheap analogue of the ACC cough analogue, pay attention to the following medicines:

• Ambroxol, country of origin - Russia. Contains the same active ingredient and belongs to the category of mucolytic expectorants. Its price is about 40-50 rubles.
• Fluimucil, country of origin - Italy. It is intended to eliminate the first signs of a cold and cough, but can be used to facilitate the discharge of a viscous secretion from the nose. Its composition consists of 600 mg of acetylcysteine, citric acid, sorbitol and flavors. The price of the drug is about 300 rubles.
• Ambrobene, country of origin - Germany. It is produced as a syrup, which is based on another active substance - ambroxol hydrochloride. The medicine helps to cope with a protracted, poorly expectorated cough, removes sputum from the bronchi, and softens the airways. Its price ranges from 200 to 300 rubles.

ACC price for cough

The release form not only contributed to the freedom of choice of the buyer, but also significantly influenced how much ACC costs in pharmacies. More often, its price is very acceptable, which makes the medicine affordable for every social stratum of the population. However, in different cities and pharmacies, drug prices may vary slightly. The average cost of the drug is as follows:

• children's syrup - price up to 350 rubles;
• granulated ACC - up to 200 rubles;
• powder - 130-250 rubles;
• powder with orange and honey flavor - price from 250 r.

ACC - contraindications

Contraindications to the use of ACC are as follows:

• individual intolerance to the active substance;
• hypersensitivity to additional components medicines;
• illness during pregnancy, during lactation, excluding artificial feeding;
• ulcer duodenum and stomach;
• liver failure;
• history of pulmonary hemorrhage.

In addition, the drug is highly undesirable to use together with other cough syrups, bronchodilators and antibiotics containing codeine and depressing expectorant reflexes. With caution, you should drink the medicine for those who have previously been diagnosed with venous varicose veins, adrenal diseases or abnormalities in the endocrine system.

Side effects of ACC

Overdose symptoms and side effects of ACC appear as:

• allergic reactions: pruritus, urticaria, dermatitis, laryngeal edema, anaphylactic shock;
• deterioration of health: muscle weakness, drowsiness, ringing in the ears, rapid heartbeat, migraine;
• stool disorder: severe diarrhea;
• indigestion: nausea, heartburn, the appearance of a gag reflex after taking the pills.

Video: ACC abstract

ACC - reviews

Anton, 54 years old

I suffered from a cough for a long time. I can’t say that he was dry, but the sputum still didn’t come out. I decided to go to the hospital and the doctor advised me to try ACC long in effervescent tablets. I drank the course, as it was said to the instructions for the medicine - 5 days. The cough has not gone away at all, but breathing has become much easier, and sputum is already coming out of the bronchi.

Anastasia, 32 years old

At the beginning of the treatment of a wet, persistent cough, a friend advised me to try ACC powder. When I came to the pharmacy, at first I was embarrassed because of the price of the medicine. It cost somewhere around 130 rubles, which is very strange and inexpensive compared to analogues. I decided to try it anyway and was not mistaken, the cold went away in 3 days, and my breathing returned to normal.

Cough medicines do not inhibit the body's reflex reaction to clear the bronchi. They are necessary to eliminate the cause of this unconditioned reflex- irritation from the accumulated discharge.

The ability to suppress the cough reflex is distinguished by antitussive drugs (Sinekod, Libeksin), which are prescribed to combat painful coughing fits.

Antitussive drugs are prescribed in the absence of mucus in the respiratory tract, scanty discharge.

Wet cough is not treated with antitussives. With a large accumulation of mucus, their use disrupts the excretion of mucus, the patient can literally suffocate due to blockage of the respiratory tract with discharge.

Used for cough in bronchitis wide range tablets of different names of natural, synthetic origin. Most often, doctors prescribe for bronchitis:

Cough preparations

Inflammation of the bronchi is treated with drugs containing bromhexine, ambroxol or acetylcysteine ​​as the active ingredient. These Synthetic Compounds Are More Effective Than Drugs plant origin, such as, for example, Mukaltin.

Bromhexine and analogues

The action of the substance is based on the destruction of polysaccharides, which are part of the sputum, due to which it liquefies. The active ingredient Bromhexine is found in large numbers drugs, including, for example:

How bronchitis is treated in adults when there is no temperature, we described in detail in a separate article.

Analogues of Ambroxol

Synthetic substance ambroxol is a derivative of bromhexine, used in inflammatory processes, used as a mucolytic with anti-inflammatory properties. Ambroxol is contained in medicines:

Ambrobene is considered an effective remedy for thinning sputum with scanty discharge. Preparations containing ambrobene improve the separation of mucus from the surface of the bronchi, stimulate its excretion.

Means with acetylcysteine ​​(ACC)

Medicines with ACC are prescribed for viscous sputum to thin it, better discharge. Drugs with ACC are used from purulent bronchitis and cough with a thick discharge, which is possible due to the ability of acetylcysteine ​​to remain active in the presence of pus, blood.

ACC, like Ambroxol, is a vital essential medicines, is available in every pharmacy, and prices for it should be controlled by the state.

Acetylcysteine ​​effervescent tablets are used for bronchitis:

Tablets with acetylcysteine ​​are not prescribed for children under 14 years of age, they are not used simultaneously with antitussive drugs because of the danger of sputum stagnation.

For the treatment of all types of bronchial inflammation, drugs such as ACC, Bromhexine, Fluimucil are most often used. These drugs help to remove sputum from the bronchi with increased secretion of mucus.

Tablets with herbal ingredients

With increased secretion of mucus, the combined remedy Bronchipret will help to cope with the increasing volume of sputum, accelerate its excretion. This medicine belongs to natural preparations of plant origin, includes an extract of primrose, thyme.

With a slight discharge of sputum, a positive effect is achieved by using Travisil absorbable tablets. The manufacturers of this remedy have provided for the treatment of people suffering from diabetes by releasing Travisil, which does not contain sugar.

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Is it possible to take ACC and Bromhexine at the same time?

In theory, it's possible. Both bromhexine and acetylcysteine ​​promote the evacuation of sputum from the lungs. In the annotation, I did not see that these drugs interacted with each other in any way. For example, bromhexine is not recommended for use with drugs that suppress the cough center, as this will lead to stagnation of sputum and the growth of bacteria in the secret. But acetylcysteine ​​works differently.

Personally, I did not come across combined preparations with acetylcysteine ​​and bromhexine. But bromhexine itself is not an active substance and it begins to work only after a change in the liver, where it turns into ambroxol. But drugs that contain both acetylcysteine ​​and ambroxol exist. For example, Pulmobreeze.

No you can not. Why would you take two mucolytic drugs at the same time? This is inappropriate and even dangerous. You do not take ketorol, nise and diclofenac for pain at the same time? Choose one drug, and drink it according to the instructions. Personally, I like it more.

These two drugs, ACC and Bromhexine, have approximately the same effect, they cope well with a wet cough, however, judging by the price, ACC will still be more expensive. True, and drinking it is more pleasant, for example, it is much easier to persuade my child to drink sachet of acc than a bromhexine tablet.

Well, the taste is also different, it will be more pleasant.

And since both drugs do a good job of their task, so there is simply no point in using them at the same time, coughing twice as fast will definitely not go away.

You can take it together, but why?

The drugs ACC and Bromhexine do not conflict with each other, so the ban on joint reception no, but the question is, why take them together? Double medicine means double side effects, double harm. Only a doctor can decide whether to intensify treatment with another antitussive drug, or you can get by with one and only he will help. Of course, there are cases when a doctor can prescribe to take both ACC and Bromhexine, but this is rather an exception, and you cannot make such a decision on your own, without a doctor.

If the cough went down deep and it is difficult to breathe, then of course it is possible - I had this once and the doctor recommended that I do just that so as not to take an antibiotic - it turned out so to say Double punch coughing and that's what helped me cope.

Of course, the effect of the drug is the same.

Is it possible to take ACC and Bromhexine at the same time and which is better

Cough syndrome is an inevitable companion of acute respiratory infections, the number of pharmacological preparations that help fight it is very large, and sometimes, having come to the pharmacy and looking at the window, a person thinks: ACC or Bromhexine, which is better to help cope with a cough? Both of these drugs have an antitussive purpose, but at the same time, each of them has its own subtleties in terms of pharmacological action which must be taken into account when using them. Experts are well acquainted with them, so it would be more correct to leave the right of choice to the attending physician.

What are the similarities and differences between these commonly used cough remedies?

Bromhexine has been sold on the Russian pharmacological market for more than 15 years and is well known to both doctors and patients.

The main forms of the drug are available in the form of:

• solution for injection;
• solution for internal use;
• dragee;
• drops;
• syrup;
• tablets.

All of them, with the exception of the first, intended for intravenous administration, taken orally, i.e. enter the body by ingestion, and are prescribed by doctors to adults and children in order to correct the painful condition that occurs during acute respiratory viral infections, one of the symptoms of which is cough.

Acetylcysteine ​​(ACC) is a newer antitussive compared to Bromhexine, but has already proven itself well in adults and children. It is available in two main forms: in the form of syrup and granules, soluble in boiled water.

Both forms children agree to drink very willingly thanks to good taste medicine flavored with an orange additive. In addition, effervescent granules, dissolving in water, make the medicine look like a fruit drink.

Take ACC, like Bromhexine, experts consider it acceptable, starting from the age of 2 years.

As for babies, these funds should be given to them with great care and only under the supervision of a doctor. Increased sputum production can cause an attack of suffocation in an infant whose respiratory function is imperfect, and coughing skills have not yet been formed, therefore, to facilitate the process, experts recommend that the child be given chest drainage massage simultaneously with taking antitussive drugs.

pharmachologic effect

Main active component Bromhexine is the hydrochloride of this substance, which has a mucolytic (thinning sputum), antispasmodic (relieves spasmodic reaction smooth muscle bronchi, causing cough) and expectorant action. It is usually prescribed for:

• pharyngitis;
• laryngitis;
• acute and chronic forms of bronchitis;
• inflammation of the mucous membrane of the trachea, causing tracheitis or tracheobronchitis;
• sharp and chronic inflammation lungs.

With all these diseases, a characteristic symptom is a dry, unproductive cough without expectoration, traumatizing the inflamed mucous membrane of the respiratory tract. Bromhexine is used to relieve such symptoms. Its use during an illness helps to quickly transfer the cough syndrome from a dry and unproductive to a wet productive form, and when wet form- it is better to cough up and remove sputum masses from the respiratory tract, which are nutrient medium for pathogens. The effect is achieved, among other things, by activating the work of the ciliary mechanism of the epithelium, which provides improved pumping of air masses. Such cleaning significantly speeds up the process of normalization of functions. respiratory apparatus after a person has suffered acute respiratory viral infections.

The effect on the body of ACC is almost the same, therefore, the indications for use are the same. In addition, it is recommended for admission with such serious illness like cystic fibrosis.

Dosage, side effects, contraindications

In children under six years of age, the use of Bromhexine is allowed in liquid form.

The approximate dosage is:

• for a child from two to six years old - 4 mg three times a day;
• from six to fourteen - 8 mg three times a day.

The adult dose can be equal to 16 mg per two doses.

Tablet forms are intended for children six years of age and older, as well as adult patients. Their volume is 1-2 tablets three times a day. Specific dosage recommendations are given by the attending physician.

The duration of the course should be at least 10, but not more than 14 days. As a rule, a positive effect appears on the third or fifth day, but if you have been taking the medicine for a week without noticing positive dynamics, you should discuss with your doctor the advisability of taking it.

Taking the drug in any form is contraindicated:

• children under two years of age;
• women in the first trimester of pregnancy and during breastfeeding;
• persons with individual intolerance to the components that make up the drug.

Side effects may include headache, dizziness, nausea, vomiting, diarrhea, skin rash. When similar symptoms you should immediately stop taking the medicine and consult with a supervising specialist.

The dosage of ACC also depends on the age of the patients. Adults and adolescents from 14 years old are allowed to take 200 mg of the drug 2-3 times a day, from six to 14 years old - three times a day, 100 mg, or 2 times 200 mg, from two to six - 100 mg twice per day. The attending physician calculates the dose for patients with cystic fibrosis on an individual basis, depending on the severity of the condition.

The course of admission for ARVI is 5-7 days, in chronic forms its duration is set by a specialist.

List of contraindications, in addition to age under two years, pregnancy, lactation and individual intolerance, includes varicose veins of the esophagus, bronchial asthma, renal and hepatic insufficiency, as well as diseases that may result in hemoptysis.

Many patients ask themselves: what will happen if Bromhexine and ACC are taken together, and is it possible to do this? The opinions of experts on this matter differ, and there is no categorical prohibition. But, since their action, in principle, is of the same plan, it is not advisable to use both drugs at once.

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Our immunity is directly dependent on our lifestyle and nutrition. Only a small part of it was originally laid down genetically. During life, a person acquires immune deficiency, which subsequently leads to various kinds diseases, allergic reactions and poor health. By taking care of your diet, you will take care of your immunity, which will subsequently save you from many health problems. This test will show you what to look for in your current diet. What to add, what to reduce, and what should be completely abandoned.

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We urgently need to change something!

Judging by nutrition, you absolutely do not care about immunity and your body. Most likely, you often get sick, suffer from bowel problems, and you are haunted by a feeling constant fatigue. It's time to love yourself and start getting better. It is urgent to adjust your diet, to minimize fatty, floury, sweet and alcohol. Eat more vegetables and fruits, dairy products. Nourish the body by taking vitamins, drink more water(precisely purified, mineral). Harden the body, reduce the amount of stress in life, think more positively and move to healthy eating it will be much easier, you just need to start.

Your immune system is in fairly good condition.

So far so good, but if you do not start taking care of her more carefully, then health problems may begin (if there were no prerequisites yet). Namely, allergies, frequent colds, intestinal problems and other “charms” of life are accompanied by weak immunity. You should think about your diet, minimize fatty, starchy foods, sweets and alcohol. Eat more vegetables and fruits, dairy products. To nourish the body by taking vitamins, do not forget that you need to drink plenty of water (purified, mineral). Harden your body, reduce the amount of stress in life, think more positively and your immune system will be strong for many years to come.

Congratulations! Keep it up!

You care about your nutrition, health and immune system. Keep up the good work and health problems will not bother you for many years to come. Do not forget that this is mainly due to the fact that you eat right. Eat healthy and nutritious foods (fruits, vegetables, dairy products), don't forget to use a large number of purified water, harden your body, think positively. Just love yourself and your body, take care of it and it will definitely reciprocate.

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Do you eat healthy and wholesome food?

• Always
• I aspire to it

How often do you eat foods that are high in sugar?

• Daily
• Few times a week
• Once a month or less
• I don't use at all

Do you spend fasting days Or any other cleansing procedures?

• 1-2 times a week
• Several times a month
• Several times a month

How many times a day do you eat?

• Less than 3 times
• Breakfast lunch and dinner
• More than 3 times

What type of people do you consider yourself to be?

• Optimist
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How often do you eat bakery and pasta products made from light flour?

• Daily
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What foods do you eat for breakfast?

• Porridge, yogurt
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Are you taking antibiotics?

• In urgent need

How often do you eat vegetables and fruits?

• Daily
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• Very rarely

What kind of water do you drink?

• mineral
• Cleaned with household appliances with filters
• boiled
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How often do you consume dairy products?

• Daily
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Do you always eat at the same time?

Is it possible to take Bromhexine and ACC at the same time

In the treatment of cough, it is necessary to use drugs with an effect on all mechanisms of the pathogenesis of cough. Bromhexine inhibits the activity of the cough center, ACC is a means of suppressing the peripheral mechanism of cough.

So Bromhexine and ACC is the most competent combination of antitussives.

As a rule, taking one drug does not help, because therapeutic effect on one of the pathological links of cough.

ACC - cheap analogues (list), instructions, comparison of effectiveness

Cough is the body's response to absolutely various diseases respiratory tract, often of an inflammatory nature. Sometimes it goes away on its own and does not require outside help. But, with a weakened immune system, the cough drags on for a long time, tormenting the patient and giving him a lot of inconvenience.

For the treatment of inflammatory pathologies of the bronchopulmonary system, there are many drugs, one of which is ACC. It is used to treat dry and wet (wet) cough, both in adults and in pediatrics. ACC is a safe and popular remedy that has repeatedly proven its effectiveness in the fight against viscous sputum, but because of its high cost, cheap ACC analogues are becoming popular. Pharmacological affiliation - mucolytic, ATX code: 05CB01.

Main properties, composition and form of release of ACC

Acetylcysteine, the main substance of ACC, has a pronounced anti-inflammatory, expectorant, thinning and antioxidant effect. The main task of the drug is to thin and remove sputum that is difficult to separate from the respiratory tract. Thanks to the cleansing of the bronchi, inflammation is removed, cough is eliminated, and the protective function of the mucosa is restored.

ACC with a dry cough is most in demand, so there is no doubt whether to purchase the drug or not. It is necessary as soon as possible to help the bronchi to be cleared of sticky sputum, which prevents the patient from recovering. Cough is not able to expel such sputum, so mucolytics will be required. ACC and its analogues, cheap or more expensive, allow the bronchopulmonary system to get rid of accumulated mucus and get rid of cough.

For ease of use, the drug is available in different forms. Patients can use effervescent tablets, hot drink(prepared from powder), solution (base - powder). One of the latest innovations of Salutas Pharma GmbH (Germany) is ready-made syrup, which is available in bottles of 100 and 200 ml.

By palatability ACC has variety. There are forms with orange, cherry, lemon and blackberry flavors.

The action of ACC occurs on the first day of admission, and on the second day, patients note that they have wet sputum, and they already have something to expectorate. The feeling of tightness, pain, and other more unpleasant symptoms in the sternum are reduced.

What pathologies are treated with ACC?

The drug is used for all diseases accompanied by the accumulation of viscous, thick and difficult to separate sputum in the bronchi. These pathologies include:

• acute and chronic bronchitis;
• COPD (chronic obstructive pulmonary disease);
• pneumonia;
• bronchial asthma(mild and moderate degree);
• bronchiectasis;
• lung abscess;
• tracheitis and laryngotracheitis;
• cystic fibrosis ( systemic disease, in which the secretion of mucus in the body is disturbed);
• sinusitis;
• inflammation of the middle ear.

For the treatment and prevention of the common cold, tonsillitis, acute respiratory viral infections and influenza in children and adults, Elena Malysheva recommends the effective drug Immunity from Russian scientists. Due to its unique, and most importantly 100% natural composition, the drug has an extremely high efficiency in the treatment of sore throats, colds and strengthening immunity.

How to dose the drug correctly?

Depending on the disease, the severity of symptoms and the age of the patient, the dose of ACC may vary.

So with cystic fibrosis, the maximum daily dose up to 800 mg, while the patient's body weight should not be less than 30 kg.

Infants (from the third week of life) and babies up to 2 years of age are prescribed up to 150 mg per day, dividing the dose by 50 mg. Children from 2 to 5 years old are allowed to give up to 400 mg per day (we divide the drug into 4 doses). After 6 years, the maximum daily dose increases to 400-600 mg per day, it is also divided (three doses per day).

With uncomplicated cough, the course of treatment for ACC is a week. If necessary (chronic diseases), the drug is used up to 6 months.

ACC is dissolved in a liquid (100 ml), it is better to use water, but you can also use compote, juice, cool tea. Reception is made after meals. Doctors do not advise drinking ACC before bedtime, because. increased sputum outflow, even in horizontal position may exacerbate coughing. Therefore, the last dose should be immediately after dinner (around 18:00).

Instructions for use ACC prohibits the use of the drug in the following cases:

• intolerance to acetylcysteine ​​and all complementary components;
• severe allergic anamnesis;
• bleeding from lung tissue;
• tendency to bronchospasm;
• hypotension;
• hemoptysis;
• fructose intolerance;
• ulcerative processes of the gastrointestinal tract;
• hepatitis and more severe kidney disease in children.

Against the background of taking ACC, the following negative reactions are possible:

• a sharp decrease in blood pressure;
• headache;
• the appearance of noise in the ears;
• nausea, diarrhea;
• stomatitis;
• itchy dermatoses;
• tachycardia;
• asthma attack;
• other.

Clinical trials of ACC did not reveal a negative effect of the drug on the fetus, however, it is not recommended to use it at all gestational ages and during breastfeeding.

If the patient is not satisfied with the price or side effects appear, ACC can always be replaced with cheaper analogues, both domestic and foreign. In this case, it is better to use drugs with a different active substance, because. structural analogues With highly likely will cause the same unwanted symptoms.

ACC - cheap analogues for children and adults

To determine which analogues will be cheaper, let's first look at some ACC prices:

• orange granules No. 20 - 140 rubles;
• syrup 200 ml - 350 rubles;
• syrup 100 ml - 225 rubles;
• ACC 200 tablets No. 20 - 250-320 rubles;
• ACC long 600 mg effervescent tablets No. 10 - about 400 rubles.

The most popular analogue of ACC is the Swiss drug fluimucil. It is a structural analogue, and has much in common with ACC, even their price is the same.

1. You can buy cheaper, for example, acetylcysteine ​​​​made in Estonia (Vitale-HD). At a lower price, you can also buy drugs Ambrohexal, Ambrobene or domestic drug ambroxol. These funds have another active substance - ambroxol.
2. Bromhexine is also considered a cheap analogue of ACC. The price for 100 ml of syrup (Russia) is 80 rubles, made in Latvia - 125 rubles.
3. popular but more expensive analogues, ascoril and lazolvan are considered.

To replace the drug, always contact the specialist who prescribed the cough treatment. If this is not possible, you will have to work a little on your own. To do this, you need to take the instructions for the main drug, in our case it is ACC, and compare it with the intended substitute.

Many instructions already give a hint in the form of a list of potential analogues. The main thing is to pay attention to the list of warnings, indications, as well as age, especially when the child needs therapy. In principle, it is necessary to conduct a comparative assessment, and highlight all the advantages of the analogue.

Which is better - ACC or its analogues? Such a concept has its own relativity, since for one patient, for example, ACC is suitable, and for another, a remedy with a different composition. The clinical picture of the disease, the intake of concomitant medicinal substances, a history of chronic pathologies - all this together affects the exact determination of the desired drug. That's why without medical education It is not advisable to conduct experiments on yourself and your loved ones.

Comparing drugs, you can only highlight the pros and cons in order to better navigate the choice of analogues, as well as acquire a less toxic and more effective remedy.

ACC or lazolvan - which is better to choose?

The drugs differ in their composition, therefore, they are not structural analogues. The active substance of ACC is acetylcysteine, in lazolvan the main component is ambroxol. Funds are issued different countries. ACC is produced by companies in Slovenia and Germany, and lazolvan is produced by France, Germany, Spain and Greece.

In terms of the number of dosage forms, lazolvan has an advantage, it has five of them, while ACC has only three.

Both drugs have a pronounced mucolytic effect, i. liquefy sputum, but their mechanism of "work" is different. Unlike lazolvan, ACC also exhibits antitoxic and antibacterial effects.

Sometimes the funds in question are prescribed in parallel. One drug is taken orally, the other is used by inhalation.

In pediatric practice, lazolvan is successfully used from a very early age, and ACC, starting from two years (for cystic fibrosis from birth). Lasolvan is often used for inhalation, so some pediatricians prefer it.

The price of drugs depends not only on the dosage form, but also on the country of manufacture. In general, the funds under consideration are close in price, and may differ within 20%, and in some pharmacies, lazolvan is more expensive, in others, on the contrary, ACC.

What is better ACC or Ambrobene?

The drugs differ in their composition, but they have the same pharmacological affiliation - mucolytics. The active ingredient in Ambrobene is Ambroxol hydrochloride.

Ambrobene's variety of dosage forms (there are five of them) is an advantage over ACC.

According to recent studies, it has been established that ambrobene has antiviral activity, has a mild analgesic effect, relieves inflammation, and removes toxins. Studies have also shown that ambroxol hydrochloride slows down the spread of the harmful protein alpha-synuclein, which causes the progression of a severe disease like Parkinson's disease.

Despite how ACC method and ambrobene act, their main task is one - to save the patient from thickened sputum.

We also allow the combined use of these funds. This combination is indicated when the disease becomes more serious.

According to the observations of pediatricians, and taking into account the instructions for the preparations, for the smallest patients, including infants, it is better to use ambrobene.

As for the price, let's do a little calculation. For a course of cough treatment with ordinary viral infection you will need about 20 tablets of ambrobene. The price for them is 150 rubles. ACC tablets 200 No. 20 cost about 300 rubles, this amount is also suitable for a course of treatment.

So, we see that the treatment of ACC will cost twice as much. Which is better to choose is up to the doctor and the patient.

ACC or fluimucil - which works better?

The means under consideration are structural analogues, and this suggests that they have the same principle of action. After taking both drugs, the productivity of cough improves markedly by the end of the first day of administration, and after a few days this symptom itself recedes due to the release of sputum and the cleansing of the bronchopulmonary tree.

Firms and countries-manufacturers for drugs are different. Someone prefers the products of Switzerland or Italy (fluimucil), and someone prefers Slovenia and Germany (ACC).

If somewhere you can find significant differences in the presented funds, then these are the forms of release. These funds have various variations not only in the form of release, but also in dosages, which makes it possible to use the medicine at any age. It should be noted right away that according to these criteria, ACC has an advantage.

For example, ACC has a syrup, but fluimucil does not have this form. But fluimucil has a solution for oral administration, inhalation and injection (ACC does not have such forms). More details about all doses and forms are written in official instructions, where you can more clearly see the information of interest.

Pulmonologists consider the undoubted advantage of fluimucil to be the use of an agent for inhalation and injection, due to which acetylcysteine ​​gets to its destination faster. This speed of action of the drug is especially important in acute cases of the disease.

Popular in children's practice more syrups, so it’s better for kids to advise ACC in cherry-flavored syrup. But anyway the right drug children are selected only by a pediatrician.

Parents must make sure that the child takes the syrup correctly. It is also important to give patients an alkaline drink to enhance the action of ACC or fluimucil.

Comparing prices, it was noted that fluimucil in the form of effervescent tablets at a dose of 600 mg (about 150 rubles for 10 pieces) would be the cheapest. The price of ACC for the same dose and number of tablets is much more expensive, and is about 400 rubles. The cost of other forms is not particularly different, fluimucil is literally 10% cheaper.

Bromhexine or ACC?

The drugs are analogues only in therapeutic action. The active substance of bromhexine repeats its name, the drug is classified as a stimulant of the motor function of the respiratory tract and secretolytics.

As well as ACC Bromhexine affects the secretion of secretion by the glands of the bronchi, due to which thick sputum is liquefied. Under the influence of the means under consideration, sputum secretion and its evacuation from the bronchi improves.

The toxicity of ACC is lower, so the list of contraindications is shorter. Bromhexine perfectly suppresses the cough center, and ACC acts on the peripheral cough mechanism. This feature of these funds allows you to prescribe them in a complex, and the effect of treatment is much better than a single dose. The drugs complement each other perfectly.

Despite this possibility, this is not a reason to immediately take ACC and Bromhexine together. It all depends on the clinic. inflammatory process and the ability of the bronchi to self-purify.

All forms of bromhexine are lower in cost, for example, the price of its 100 ml syrup is 100 rubles cheaper than the same syrup from ACC.

ACC or Askoril?

Comparing these drugs, let's pay attention, ACC is a mono drug (the active component is acetylcysteine), and ascoril is a combined remedy, which includes three active substances: bromhexine, guaifenesin and salbutamol.

Even ordinary person, without a medical education, it will be clear that ascoril has a more powerful effect, tk. equipped with three medicinal substances. In addition to the mucolytic and expectorant effect, ascoril also has a bronchodilator property (relieves spasm of the smooth muscles of the bronchi). Simply put, it relieves the feeling of tightness in the chest (suffocation).

If you look at the offers of pharmacies, then in most cases ascoril and ACC will practically coincide in price. So, for example, the price for a bottle of syrup in 200 ml is approximately 400 rubles for both drugs.

The cardinal difference between the drugs in question is that ascoril is not used for coughing, which is not accompanied by obstruction and asthma attacks.

ACC and its analogues help both dry and wet cough, and choose a substitute according to active ingredient or suitable drug for therapeutic action - to decide the doctor. Especially unacceptable independent appointment medicines such as ascoril, which contains the active substance (salbutamol), which dilates the bronchi.

Do not select analogues at your own peril and risk, approaching the choice based only on the price, cheaper does not mean more efficient! Competent appointment - a chance for quick healing! Be healthy!

And some secrets.

If you or your child gets sick often and is treated with antibiotics alone, know that you are only treating the effect, not the cause.

So you just “drain” money to pharmacies and pharmaceutical companies and get sick more often.

STOP! Enough to feed someone you don't know. You just need to boost your immunity and you will forget what it is to get sick!

With the rest you can.

Not current mona, dada nuna! (With)

there you need a run-up and antibiotics at 2 hours, that is, a difference in intake, because acetylcysteine ​​\u200b\u200bcan destroy the antibiotic.

and it is possible, and it is necessary, if the doctor has appointed or nominated.

I can add that it is better to drink ACC Long 600 mg according to the scheme: 300 in the morning + 300 in the evening, each time dissolving in a glass of water. In the evening, take no later than 20 hours, an hour before that, drink tablets "Cough tablets" (2 tablets dissolved in half a glass of water). Why not later? to stop coughing at night. And be sure to drink plenty of fluids so that ACC has something to thin your sputum. During treatment, drugs with Codeine should not be taken.

ACC is a sputum thinner, always used with antibiotics, for pneumonia, bronchitis.

Granules in sachets of 100 or 200 mg, 600 mg effervescent tablets

ACC® 100 - one sachet contains 100 mg of acetylcysteine ​​in the form of granules for preparing a solution for oral administration(20 sachets per pack). One sachet contains 2.9 g of sucrose.

ACC® 200 - one sachet contains 200 mg of acetylcysteine ​​in the form of granules for oral solution (20 sachets per package). One sachet contains 2.8 g of sucrose

ACC® LONG - one effervescent tablet contains 600 mg of acetylcysteine ​​(10 tablets per pack).

Registration certificate No. 2132, 2293

pharmachologic effect

ACC® is a mucolytic expectorant used to thin sputum in diseases respiratory system accompanied by education thick mucus. Due to the presence of a free sulfhydryl group, acetylcysteine ​​loosens disulfide bonds in sputum, which leads to depolymerization of mucopolysaccharides and helps to reduce the viscosity of bronchial secretions. The drug facilitates the release of sputum.

ACC® also has antioxidant pneumoprotective properties that provide effective protection respiratory organs from toxic effect negative factors environment, tobacco smoke, supports functional activity and morphological integrity of lung tissue. In addition, ACC® helps to increase the synthesis of glutathione, which is an important factor in chemical detoxification. This feature of acetylcysteine ​​makes it possible to effectively use the latter in acute poisoning paracetamol and others toxic substances(aldehydes, phenols, etc.).

Indications for use

The drug is used to treat acute and chronic pathology broncho-pulmonary system, accompanied by increased sputum production and worsening expectoration: treatment of acute and chronic bronchitis, bronchiectasis, chronic obstructive bronchitis, bronchial asthma, as well as cystic fibrosis, tracheitis, laryngitis, sinusitis, inflammation of the middle ear with effusions.

Contraindications for use

The drug ACC® is not recommended to be taken in the presence of hypersensitivity to acetylcysteine ​​or to its other constituents. In newborns, ACC® can only be used for health reasons under the strict supervision of a physician.

What you need to know if you are pregnant or breastfeeding

Animal studies (rats, rabbits) show no teratogenic effect of ACC®. To date, there are not enough observations of the use of acetylcysteine ​​during pregnancy and during breastfeeding, and therefore taking the drug during this period is possible only as directed by a doctor.

Interactions with other drugs

Antibiotics

Antibiotics of the tetracycline series (with the exception of doxycycline) are not recommended to be taken simultaneously with ACC®. Cases of inactivation of antibiotics by acetylcysteine ​​were observed exclusively during in vitro experiments with direct mixing of the latter. But for the safety of the patient oral administration antibiotics should not be combined with acetylcysteine ​​and possibly at least 2 hours apart. In vitro incompatibility has been observed with semisynthetic penicillins, tetracyclines, cephalosporins, and aminoglycosides. There is no evidence of incompatibility with antibiotics such as amoxicillin, erythromycin and cefuroxime.

Antitussives

At simultaneous application ACC® with other antitussives due to a decrease in the cough reflex, dangerous mucus stagnation is possible.

Nitroglycerine

Simultaneous administration of nitroglycerin and ACC® may lead to an increase in the vasodilating effect of nitroglycerin.

Dosing regimen

Adults and children over 14 years of age can use ACC® at a dose of 400–600 mg of acetylcysteine ​​per day.

Children from 2 to 6 years old - 200-300 mg of acetylcysteine ​​per day.

Newborns from the tenth day of life and children under 2 years of age are recommended to use ACC® at a dose of 50 mg of acetylcysteine ​​2-3 times a day up to 100-150 mg per day.

cystic fibrosis

For patients with cystic fibrosis and weighing more than 30 kg, an increase in the daily dose to 800 mg of acetylcysteine ​​is allowed.

Children over 6 years of age take ACC® 3 times a day, 200 mg (600 mg of acetylcysteine).

Newborns from the tenth day of life and children under 2 years of age are recommended to use ACC® at a dose of 50 mg of acetylcysteine ​​2-3 times a day (150 mg per day).

ACC® is recommended to be used after a meal. To do this, dissolve the composition of the sachet or tablet in 1/2 cup of water, juice or cold tea and drink the solution. Additional fluid intake enhances the mucolytic effect of the drug.

In acute uncomplicated diseases, ACC® is used for no more than 5-7 days. The duration of treatment for long-term diseases is determined separately. Treatment chronic diseases carried out for a long time or courses for several months (up to 6 months).

Side effects

In some cases, diarrhea, nausea, heartburn and vomiting may occur. In rare cases, there is a headache, inflammation of the mucous membrane oral cavity and tinnitus. There are isolated reports of the occurrence of use of ACC® allergic reactions, lowering blood pressure, bronchospasm (in patients with hypersensitivity bronchial system, for example, with bronchial asthma), rapidly disappearing skin rashes, skin itching, tachycardia.

At the first sign of hypersensitivity to ACC®, it is necessary to stop using it.

Overdose and other application errors

So far, there have been no cases of severe and life-threatening side effects and signs of overdose, even under conditions of extreme overdose.

Safety Information

Acute toxicity

The study of acute toxicity of acetylcysteine ​​was carried out in humans receiving the highest daily dose of ACC® (up to 30 g of acetylcysteine ​​per day). No signs of intoxication were observed in all cases of ACC® application.

Chronic toxicity

Experimental studies on animals (rats, dogs) indicate that long-term (up to 1 year) application of ACC® does not cause any pathological changes.

Neoformational and mutagenic potential

Exists enough studies that ACC® does not have a mutagenic effect on the body. The innovative potential has not been studied.

The study of reproduction

The study of teratogenicity was carried out on pregnant rabbits and rats during the period of organogenesis. The dose of the drug ranged from 250–500 and 700 mg/g in rabbits and about 500–1000 and 2000 mg/kg in rats.

No cases of deformities were observed. The results of the study indicate the absence of a negative impact on gonadal function, fertility and neonatal development.

Manufacturer

Hexal AG, Germany

The material was provided by the representative office of Heksal AG in Ukraine,

Kyiv, st. Pushkinskaya, 12-A, of. 16. tel.:, fax:

Actual about prevention, tactics and treatment →

Review of existing variants of prostate adenoma.

Taking ACC with antibiotics

More information about ACC can be found here.

Therapeutic action

The active substance of the drug is acetylcysteine. It belongs to mucolytics, that is, to agents that are able to thin thick, viscous, difficult-to-separate sputum.

It is prescribed for diseases of the respiratory system, which are accompanied by a cough:

• Pneumonia
• Bronchitis in acute and chronic form, as well as the accompanying obstruction
• Bronchial asthma
• Formation in the lungs of purulent foci
• Tracheitis
• Simultaneous inflammation of the larynx and trachea (laryngotracheitis)
• bronchiectasis
• cystic fibrosis
• bronchiolitis.

In addition, the drug is prescribed for otitis media and rhinosinusitis, occurring in acute and chronic form.

Acetylcysteine ​​is not an antibiotic; it is a derivative of the non-essential amino acid cysteine. When it enters the body, it direct action on rheological properties sputum and thus facilitates its discharge. This therapeutic effect The drug is based on the chemical reactions that occur in the body when it is taken. The acetylcysteine ​​molecule contains a free sulfhydryl or thiol group, which can break the disulfide bridges (covalent bond between 2 sulfur atoms) of acid glycosaminoglycans, as a result, sputum mucoids depolarize, and its viscosity decreases.

Due to the presence of a reactive thiol group, acetylcysteine ​​has antioxidant effects, in the body it binds to molecules free radicals and neutralize them.

Also, acetylcysteine ​​is involved in the production of glutathione, which is an antioxidant and helps detoxify the body.

If you drink ACC for prophylactic purposes in case of cystic fibrosis and chronic bronchitis of a bacterial nature, then these diseases are less likely to aggravate and proceed more easily.

When taken orally, acetylcysteine ​​is well absorbed. Passing the hepatic barrier, it is rapidly metabolized into the active metabolite cysteine. The drug is excreted from the body with urine, the half-life is about an hour. But if the patient has liver pathologies, this time is extended to 8 hours.

Respiratory diseases, accompanied by cough, often have bacterial nature. Acetylcysteine ​​is not able to suppress the pathogenic microflora, that is, it cannot remove the cause of the infection. For this purpose, antibiotics are prescribed simultaneously with it. Antimicrobials for bacterial infection must be taken, otherwise you can start the disease, which will lead to severe complications. But in order to have an effect from therapy, you need to know the compatibility of ACC with certain drugs.

drug interaction

Before taking ACC, powder, tablets and syrup must be dissolved in water. It is not recommended to dilute acetylcysteine ​​with any medications, including antibiotics, in one glass. It is also impossible to mix injection in one syringe. ACC form with other medicines.

In laboratory experiments carried out outside human body When acetylcysteine ​​was simultaneously mixed with antibiotics in a test tube, the incompatibility of ACC with the following antibiotics was proven:

• Semi-synthetic penicillins, with the exception of amoxicillin, which may be marketed under such trade names like Amosin, Flemoxin Solutab, Ecobol
• Tetracycline series, except for doxycycline, which is active substance drugs Unidox Solutab, Vibramycin
• Aminoglycazides, which include Gentamicin, Kanamycin, Streptomycin, Neomycin, Tobramycin, Amikacin
• Cephalosporin series, with the exception of loracarbef and cefuroxime, the latter is known under the trade names Zinnat, Ceftin, Zinacef
• Amphotericin B.

When ACC was mixed with these antibiotics in a test tube, they entered into a chemical reaction with the sulfhydryl group of acetylcysteine, resulting in a decrease in the therapeutic effect of both drugs.

Although drug interaction was noted only in vitro, it cannot be ruled out that such a chemical reaction in the human body, and this, in turn, can reduce the effect of treatment, lead to the progression of infection and the development of severe complications.

Therefore, after taking ACC, these antibiotics can be drunk no earlier than after 2 hours. If liver diseases are observed, this time should be increased, since in such patients acetylcysteine ​​is excreted from the body longer.

Also, this interval must be maintained when prescribing injectable forms of antibiotics and ACC.

In laboratory experiments, inactivation of erythromycin and thiamphenicol was not observed.

There is even a ready-made dosage form, in which both acetylcysteine ​​and thiamphenicol are produced under the trade name Fluimucil-antibiotic IT. This medication is a partial analog of the drug ACC. In addition to the mucolytic action of Fluimucil-antibiotic IT, it exhibits antibacterial activity against staphylococci, Haemophilus influenzae, streptococcus causing pneumonia, Klebsiella, Neisseria and some anaerobes. Like any antibiotic, the drug is available by prescription.

Is it possible to take ACC and this or that antibiotic together, it is better to check with the doctor. Since the same drug can be found on sale under different trade names, and a person far from medicine can easily get confused in them.

You also need to remember that ACC cannot be taken simultaneously with antitussives, they suppress the cough reflex, and this leads to the fact that sputum stagnates in the lungs. Therapeutic effect from acetylcysteine ​​is reduced when taken with activated charcoal.

Can ACC and antibiotics be taken together?

Is it possible to take ACC and antibiotics at the same time?

ACC (Acetylcysteine) can be taken with antibiotics, but not together, not at the same time, there should be a break of two hours between doses. During treatment, you first need to take ACC, after two hours an antibiotic.

ACC penetrates into the mucous membrane of the bronchial tree, the action of the drug makes it easier for antibiotics to penetrate to the sites of inflammation. ACC increases the effectiveness of antibiotic treatment.

If the doctor prescribed an ACC and an antibiotic, then you need to take only the antibiotic that was prescribed, you should not change the treatment regimen on your own.

Yes, ACC and antibiotics can be taken in parallel, but not at the same time. If we are talking about any pulmonary infection, then such therapy is quite rational. Antibiotics fight the pathogen. At the same time, thanks to ACC, sputum comes out of the lungs, and a person’s cough disappears.

However, if it is likely that aceticysteine ​​will weaken the effect of certain antibiotics: tetracyclines (except doxycycline), cephalosporins, semi-synthetic penicillins, some aminoglycosides. Therefore, it is worth distinguishing between the reception of the first and second. It is worth drinking ACC in the morning and if you choose ACC Long, which contains a daily dose of acetylcysteine, then you can drink only one tablet / packet per day. And after two hours, you can start taking an antibiotic if it belongs to the indicated groups.

I took it at the same time, because the doctor prescribed an antibiotic, but she didn’t prescribe anything for cough, so I had to self-medicate.

It was only in this question that I found out that this is not possible.

At simultaneous reception ACC and azithromycin, the antibiotic still works, perhaps not the way it would if the intake of these drugs was separated by time. You recover quickly, but the cough does not go away completely, ACC has a reception period that should not be exceeded, so after the end of the ACC intake, it remains small residual cough and must be treated with medicinal herbs. Still, it turns out that ACC and an antibiotic are not the best and most effective combination.

ACC can be taken in combination with antibiotics only with a doctor's prescription and take a break of at least 2 hours between taking the drugs. Since if you take them at the same time, ACC can weaken the effect of antibiotics and the treatment will not have the desired effect.

It is better not to take antibiotics without permission, as you do not know about the compatibility of these drugs with other drugs. Especially if you take any medications on an ongoing basis.

You can use the drug ASS in complex therapy with antibiotics, if the doctor prescribed these same antibiotics. Of course, you need a break between preparations of at least 15 minutes, but about an hour is better. ASS and antibiotics are completely different drugs and do not replace each other and do not interfere in the complex

For what purposes, if self-treatment, it’s very useless, since you won’t be able to make a diagnosis yourself, and the doctor will be able to listen to you in order to prescribe the right treatment.

ACC compatibility with antibiotics

I hope that I will find more valuable answers to this question on the net than the smart people wrote here.

Amoxiclav is amoxicillin plus clavulanic acid.

And AMBROXOL or AMBROBEN 1 ton / 3 rubles a day for 5 days.

PLUS plenty of fluids to drink.

Every winter escalates (work on the street).

This is the only way we are saved. Improvements are noticeable the very next day.

ACC compatibility with antibiotics

Consultations are carried out by specialists and scientists with higher pharmaceutical education. The section "Question to the pharmacist, pharmacist" is an independent consulting section of the ISSF WebApteka.RU. We guarantee the independence of our answers from the financial interests of specific manufacturers of medicines, dietary supplements, distributors and other similar organizations.

We kindly ask you: before asking a question, check if other users have asked it before ( use keyword search among existing questions and answers).

Omez is applied 30 minutes before meals.

Ferrum lek - during or immediately after a meal.

ACC - immediately after a meal.

Reception of Trichopolum and Karsil does not depend on food intake.

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Pneumonia, antibiotics and ACC

All this took 2 days. And suddenly I read in the instructions for ACC - pharmacologically incompatible with antibiotics such and such, incl. with cephalosporins. Reduces the absorption of antibiotics such and such, incl. cephalosporins.

Now I’m thinking if it’s possible to combine and if we replace the ACC, then with what?

something went to work today (called) and I regret it, I only stayed at home for 3 days.

Did you do physiotherapy, droppers, massage?

When I lie in the evening with a book, I sleep at night and until I get up in the morning I hardly cough. Happy for work-from work, take the child, pick up, go there, cook food - I cough.

Does this mean that you need to lie more or, on the contrary, do you need a cough to get rid of sputum? (and cough is not always productive). What else can you do to get better faster? Massage? Physio? The doctor did not prescribe anything more, maybe I should have asked about it myself?

In general, with this disease, they offer to go to the hospital, if not, then at home, bed rest. Well, unless of course you want to recover and then every year there would be no relapses.

My husband is on a business trip, so I have to do everything myself. Bed rest at home still does not work. And they offered to go to the hospital, but I have no one to leave the children with.

The boss called me to work yesterday. True, today he is already looking askance at me and asks if it is contagious and whether to let me go back.

Z.s. By the way, pneumonia is perfectly treated with antibiotics in tablets.

I go to the in vitro to give injections, in the morning - the first one, on the way to work, 5 minutes before the opening, in the evening there is no one there at all, taking the child I go in for an injection.

Why do you go to work? Well, it’s like a crisis right now, I definitely won’t find such a job anymore, they often meet me halfway - a reduced slave. day, convenient schedule - they expect the same from me. life is like this)

From physio electrophoresis with eufillin and inhalations of berodual and fluimucil.

and so on for the future - I didn’t listen to you, I don’t know the anamnesis - but you don’t indicate the temperature and I suspect the nature of the blood has not changed much. All this points (including autumn) to atypical pneumonia, and the choice of AB here is very important. This is what I mean, if in the period after 7 days after the end of ceftriaxone, the cough will still bother you, and the picture on the x-ray does not change, you definitely need to look in the direction of sumamed.

And I didn't go to work today. It turned out that my boss, who urgently called me to work, did not know what pneumonia was, and when he found out that it was pneumonia and could be infected, he himself was not happy.

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ACC compatibility with antibiotics

Granules for oral solution white color, homogeneous, without agglomerates and mechanical impurities, with the smell of lemon and honey; when sifted through a 1.5 mm sieve, no particles should remain on the sieve.

Excipients: sucrose, ascorbic acid- 75 mg, sodium saccharinate - 20 mg, lemon flavor mg, honey flavor mg.

3 g - bags of three-layer material (6) - packs of cardboard.

mucolytic drug. Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates sputum discharge due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH-groups) to bind to oxidizing radicals and thus neutralize them.

In addition, acetylcysteine ​​promotes the synthesis of glutathione, important component antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

At preventive use acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Suction and distribution

Absorption is high. Bioavailability when taken orally is 10%, due to the pronounced effect of the "first pass" through the liver. The time to reach Cmax in blood plasma is 1-3 hours.

Plasma protein binding - 50%. Penetrates through the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the BBB and be excreted in breast milk.

Metabolism and excretion

It is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.

It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T 1/2 is about 1 hour.

Pharmacokinetics in special clinical situations

Impaired liver function leads to a prolongation of T 1/2 to 8 hours.

Respiratory diseases, accompanied by the formation of viscous sputum difficult to separate (acute and chronic bronchitis, obstructive bronchitis, tracheitis, laryngotracheitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, bronchiolitis, cystic fibrosis);

Acute and chronic sinusitis;

Granules for oral solution (orange) 100 mg and 200 mg, g ranula for oral solution 200 mg

At cystic fibrosis children over the age of 6 years are recommended to take the drug 200 mg 3 times / day. Daily dose.

Children aged 2 to 5 years - 100 mg 4 times / day. Daily dose.

Patients weighing more than 30 kg with cystic fibrosis, if necessary, can increase the dose to 800 mg / day.

At

ACC ® in the form of granules for oral solution (orange) 100 mg and 200 mg are dissolved in water, juice or cold tea.

ACC ® in the form of granules for oral solution 200 mg is dissolved with stirring in 1 glass of hot water and drunk as hot as possible. If necessary, you can leave the prepared solution for 3 hours.

Granules for oral solution 600 mg

At short term colds the duration of admission is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used longer to prevent infections. In case of long-term diseases, the duration of therapy is determined by the attending physician.

The drug is taken orally after a meal. Additional fluid intake enhances the mucolytic effect of the drug.

The granules are dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Adults and adolescents over 14 years of age are prescribed 10 ml of syrup 2-3 times / day (mg of acetylcysteine).

Children aged 6 to 14 years - 5 ml of syrup 3 times / day or 10 ml of syrup 2 times / day (mg of acetylcysteine).

Children aged 2 to 5 years are prescribed 5 ml of syrup 2-3 times / day (mg of acetylcysteine).

At cystic fibrosis children over the age of 6 years, the drug is recommended to take 10 ml of syrup 3 times / day (600 mg of acetylcysteine); children aged 2 to 5 years - 5 ml of syrup 4 times / day (400 mg of acetylcysteine).

At short term colds the duration of admission is 4-5 days. At chronic bronchitis and cystic fibrosis the drug should be used longer to prevent infections. In case of long-term diseases, the duration of therapy is determined by the attending physician.

The drug is taken orally, after a meal. Additional fluid intake enhances the mucolytic effect of the drug.

ACC ® syrup is taken with a measuring syringe or a measuring cup, which is in the package. 10 ml syrup ACC® corresponds to 1/2 measuring cup or 2 filled syringes.

Using a measuring syringe

1. Open the vial cap by pushing it in and turning it counterclockwise.

2. Remove the plug with a hole from the syringe, insert it into the neck of the vial and press it in until it stops. The stopper is designed to connect the syringe to the vial and remains in the neck of the vial.

3. It is necessary to firmly insert the syringe into the stopper. Carefully turn the vial upside down, pull the syringe plunger down and dial required amount syrup (ml). If air bubbles are visible in the syrup, press the piston all the way down, and then refill the syringe. Then return the vial to its original position and remove the syringe.

4. The syrup from the syringe should be poured onto a spoon or directly into the child's mouth (in the buccal region, slowly, so that the child can swallow the syrup). While taking the syrup, the child should be in an upright position.

5. After use, rinse the syringe with clean water.

According to WHO unwanted effects classified according to their frequency of development in the following way: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000) и очень редко (<10 000), частота неизвестна (частоту возникновения нельзя определить на основании имеющихся данных).

Allergic reactions: infrequently - pruritus, rash, exanthema, urticaria, angioedema; very rarely - anaphylactic reactions up to shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the side of the cardiovascular system: infrequently - a decrease in blood pressure, tachycardia.

From the digestive system: infrequently - stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

From the organ of hearing: infrequently - tinnitus.

Others: rarely - headache, fever; in isolated cases - the development of bleeding as a manifestation of a hypersensitivity reaction, a decrease in platelet aggregation.

Peptic ulcer of the stomach and duodenum in the acute phase;

lactation period (breastfeeding);

Children under 2 years of age (syrup, granules for oral solution / orange / 100 mg and 200 mg);

Children's age up to 6 years (granules for the preparation of a solution for oral administration 200 mg);

Children's age up to 14 years (granules for the preparation of a solution for oral administration 600 mg);

Fructose intolerance, tk. the drug contains sorbitol (granules for oral solution /orange/ 100 mg and 200 mg, granules for oral solution 200 mg and 600 mg);

Sucrase / isomaltase deficiency, glucose-galactose deficiency (granules for oral solution / orange / 100 mg and 200 mg, granules for oral solution 200 mg and 600 mg);

Hypersensitivity to acetylcysteine ​​and other components of the drug.

WITH caution the drug should be used in patients with a history of gastric and duodenal ulcer; with bronchial asthma, obstructive bronchitis; hepatic and / or renal failure; histamine intolerance (long-term use of the drug should be avoided, because acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; diseases of the adrenal glands; arterial hypertension.

Due to insufficient data, the use of the drug during pregnancy is contraindicated.

For syrup: the use of the drug during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Contraindications: children under 2 years of age (drug in the form of syrup and granules for oral solution / orange / 100 mg and 200 mg); children under 6 years of age (preparation in the form of granules for the preparation of a solution for oral administration of 200 mg); children's age up to 14 years (preparation in the form of granules for the preparation of a solution for oral administration of 600 mg).

The choice of the release form and dosing regimen is carried out taking into account the age of the patient.

In bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be administered with caution under the systematic control of bronchial patency.

When using acetylcysteine, cases of severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been reported very rarely. If changes in the skin and mucous membranes occur, the patient should immediately stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.

Do not take the drug immediately before bedtime (the preferred time of admission is before 18.00).

When prescribing the drug to patients on a diet aimed at limiting sodium intake, it should be taken into account that 1 ml of ACC ® syrup contains 41.02 mg of sodium.

There is no need for special precautions when destroying unused ACC ® .

Instructions for patients with diabetes

When treating patients with diabetes, it should be taken into account that ACC ® in the form of granules for oral solution (200 mg, 600 mg, orange 100 mg and 200 mg) contain sucrose.

ACC ® in the form of granules for oral solution / orange / 100 mg and 200 mg: 1 sachet of 100 mg corresponds to 0.24 XE, 1 sachet of 200 mg - 0.23 XE.

ACC ® in the form of granules for oral solution 200 mg: 1 sachet corresponds to 0.21 XE.

ACC ® in the form of granules for oral solution 600 mg: 1 sachet corresponds to 0.17 XE.

Influence on the ability to drive vehicles and control mechanisms

There is no information about the effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Acetylcysteine, when taken at a dose of 500 mg / kg / day, does not cause signs and symptoms of an overdose.

Symptoms: with an erroneous or deliberate overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn, nausea are observed.

Treatment: conducting symptomatic therapy.

With the simultaneous use of acetylcysteine ​​and antitussives, due to the suppression of the cough reflex, sputum stagnation may occur.

With the simultaneous use of acetylcysteine ​​and oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), the latter may interact with the thiol group of acetylcysteine, which can lead to a decrease in antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbef).

Simultaneous use with vasodilators and nitroglycerin may lead to an increase in the vasodilating effect.

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.

The shelf life of granules for oral solution (200 mg, 600 mg) is 3 years.

The shelf life of granules for oral solution preparation (orange) is 4 years.

The shelf life of the syrup is 2 years; after opening, the vial should be stored for no more than 18 days at a temperature not exceeding 25 ° C.

The drug is approved for use as a means of OTC.

The provided scientific information is general and cannot be used to make a decision on the possibility of using a particular medicinal product.

There are contraindications, consult your doctor.

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Why do we cough, how do the lungs look like a tree, what is bronchiolitis and whether ACC will help to defeat a cough, read in the issue of the heading “How we are treated”.

With the first snow and a cold snap, a wave of acute respiratory viral diseases covers the country. Perhaps that's why last October, the cough medicine ACC jumped nine positions up at once in the list of the analytical company DSM Group, entering the top ten most popular (by sales value) drugs. But this, as we have repeatedly seen, does not at all guarantee its effectiveness. What does science say about this drug?

Why you need a cough

Respiratory systems of man

Wikimedia Commons

A wet cough removes mucus from the lungs with accumulated bacteria or viruses and cells of its own immune system (and in severe cases, pus or even blood) that have fallen on the “battlefield” - the so-called sputum. According to its transparency, density and color, the doctor can judge what a person is sick with, suspect purulent processes in the lungs, tuberculosis, pneumonia and other diseases in the patient in order to send them for further examination. Therefore, when answering the doctor's questions about your complaints, you need to pay attention to some of its unusual properties. A rusty shade can tell about a dangerous inflammation of the lungs - croupous pneumonia (due to the breakdown of red blood cells, red blood cells). Blood spitting may indicate tuberculosis or pulmonary vascular lesions, purulent sputum may be a sign of purulent bronchitis or lung abscess, and so on.

Where does mucus come from in the lungs, you can read in the review. In short, it is needed so that the cells of the lungs do not stick together when we exhale air. In addition, mucus helps with gas exchange in the lungs, which allows us to take in more oxygen. But in diseases of the respiratory tract, it becomes a breeding ground for microorganisms and accumulates dead cells, and even performs its usual work worse, so the body tries to get rid of it (especially since a new one is produced more or less constantly). For this, a dry cough and try to translate it into a wet one.

From what, from what?

ACC is available in the form of syrup, soluble tablets and granules for preparing a hot drink. The name ACC itself is an abbreviation for the name of the active substance, acetylcysteine. It may sound familiar to you if you've heard of cysteine ​​- after all, it's actually a derivative of the amino acid cysteine. But, unlike amino acids, the body does not use acetylcysteine ​​to build proteins, but turns it into a substance called glutathione in several steps. It is an antioxidant involved in many processes in the body.

Model of the acetylcysteine ​​molecule

Fvasconcellos/Wikimedia Commons

Glutathione is able to bind to the substance that paracetamol is converted into in the body, neutralizing its harmful effect on liver enzymes, so do not be surprised if you are offered to drink acetylcysteine ​​​​with an overdose of this drug. True, it is not entirely clear how best to use it in this case - intravenously or simply inside.

Model of the glutathione molecule

Ben MillsWikimedia Commons

Another popular use of drugs with acetylcysteine ​​is the fight against too viscous and poorly separated sputum, lung obstruction (as an additional remedy), pulmonary complications after heart or lung surgery, lung collapse (when it "sticks together") and with various injuries of this organ . It is also used in operations on the trachea and bronchi.

Also, acetylcysteine ​​is sometimes used against cystic fibrosis (a severe genetic disease in which the functioning of the external secretion glands and respiratory organs is impaired), but it does not make sense to widely recommend such treatment, according to a review of scientific articles conducted by experts from the Cochrane Collaboration, because reliable evidence is too few.

Also in vitro, acetylcysteine ​​can kill bacteria by destroying their associations - biofilms that made them virtually invulnerable to drugs. This was demonstrated by the authors of a scientific article in 2011. It is possible, by the way, that the mechanism here is similar to that which helps to separate viscous sputum: both mucus in the lungs and biofilms contain polysaccharides - long carbohydrate chain molecules. It is believed that the bonds between them are broken by acetylcysteine.

In a 2010 study, German doctors also proved that in vitro(“in vitro”) acetylcysteine ​​also inhibits the reproduction of influenza A viruses. If the antiviral effect also works on patients, it (as well as the effect on the properties of mucus) can additionally help ACC fight respiratory diseases. Let's see if he does it in public.

In the lists (not) appeared

ACC was patented in 1968. Over the years of use around the world, many results of clinical trials of the drug and patient observations have accumulated. Indeed, several Cochrane reviews at once are devoted to the use of this drug in diseases of the respiratory system.

The Cochrane Library is a database of the international non-profit organization Cochrane Collaboration, which participates in the development of guidelines of the World Health Organization. The name of the organization comes from the name of its founder, the 20th century Scottish medical scientist Archibald Cochrane, who championed the need for evidence-based medicine and competent clinical trials and wrote the book Efficiency and Efficiency: Random Reflections on Public Health. Medical scientists and pharmacists consider the Cochrane Database one of the most authoritative sources of such information: the publications included in it have been selected according to the standards of evidence-based medicine and report the results of randomized, double-blind, placebo-controlled clinical trials.

The first review was written in 2004 and summarized information from 33 scientific articles using various agents for lung injury and acute respiratory failure syndrome, but acetylcysteine ​​did not show any activity.

Several reviews concern the cystic fibrosis we have already mentioned. But the conclusions here are disappointing: the authors complain that there is very little reliable evidence. What does it mean? We are talking about randomized, double-blind, placebo-controlled studies: although the authors found about two dozen studies in total, only six fit their criteria, and even then, on their basis, acetylcysteine ​​cannot be recommended.

A double-blind, randomized, placebo-controlled method is a method of clinical drug research in which subjects are not privy to important details of the study being conducted. “Double blind” means that neither the subjects nor the experimenters know who is being treated with what, “randomized” means that the distribution into groups is random, and placebo is used to show that the effect of the drug is not based on autosuggestion and that this medicine helps better than a tablet without active substance. This method prevents subjective distortion of the results. Sometimes the control group is given another drug with already proven efficacy, rather than a placebo, to show that the drug not only treats better than nothing, but also outperforms analogues.

Another review compares the effects of two drugs, acetylcysteine ​​and carbocysteine, against acute respiratory tract infections in children. The authors reviewed 34 scientific papers on the safety of drugs, and six scientific papers that investigated the effectiveness of the drug. In general, acetylcysteine ​​has been found to be safe in children over two years of age. The effectiveness of the drugs was limited - by the seventh day of treatment, the cough clearly decreased, but it was not entirely clear what role natural recovery played in this. Not the most convincing were the data on the use of acetylcysteine ​​in bronchiectasis (expansion of the area of ​​the bronchi when they are damaged).

However, there are many clinical trials proving the benefit of acetylcysteine ​​in chronic bronchitis (but not bronchitis with complications). But inhalations with acetylcysteine ​​from bronchitis did not help. In pulmonary obstruction, numerous systematic reviews of randomized double-blind comparative trials have shown that acetylcysteine ​​promotes sputum separation and prevents further complications.

Evidence-based medicine has confirmed the effectiveness of acetylcysteine, the active ingredient in ACC, against dry cough. Also, acetylcysteine ​​is included in the list of indispensable drugs from the point of view of the World Health Organization as a specific antidote (antidote), which is used for an overdose of paracetamol. At the same time, ACC most likely will not help with cystic fibrosis, although it was included in the federal recommendations for combating the symptoms of this disease. The same is true for lung injuries.

It must be understood that despite its effectiveness against cough, ACC by itself is far from always enough to cope with the infection - the cause of the disease. Therefore, in the case of pneumonia, for example, you will need antibiotics, and to combat other symptoms - pain, weakness, fever - antipyretics and pain medications may come in handy. If you also have a stuffy nose, you may need medicine for a runny nose.

It is possible to choose the right combination of drugs and decide whether an antibiotic is needed only by making the correct diagnosis. Sometimes this requires laboratory analysis (for example, to find some specific bacteria), so it is better to visit a doctor.

Acetylcysteine ​​is prescribed in all cases of diseases with accumulation of thick viscous sputum in the bronchial tree and upper respiratory tract, namely:

Acute and chronic bronchitis, including obstructive;

bronchiolitis;

Tracheitis;

Bronchial asthma;

bronchiectasis;

cystic fibrosis;

Laryngitis;

sinusitis;

Median exudative otitis.

ACC pharmacological action

The active ingredient is acetylcysteine, a derivative of cysteine ​​(amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and increases the viscosity of bronchial secretions. As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (the detoxifying effect is possible due to increased production of glutathione).

Acetylcysteine ​​with internal use is almost immediately completely absorbed from the gastrointestinal tract. The active metabolite is cysteine, which is formed in the liver. Further, the metabolism of acetylcysteine ​​passes through the formation of diacetylcysteine, cystine. The end product of metabolism is mixed disulfides.

Bioavailability is 10%. Cmax is determined for internal use after 1-3 hours. Plasma proteins bind 50% of acetylcysteine. The maximum concentration of the pharmacologically active metabolite in the blood is 2 µmol/L.

Inactive metabolites are excreted in the urine (inorganic sulfates, diacetylcysteine), however, a non-cordial amount of acetylcysteine ​​is excreted unchanged in the feces.

The half-life of acetylcysteine ​​depends on biotransformation in the liver. In liver failure, it is 8 hours, while normally it is 1 hour. It passes through the hematoplacental barrier and can accumulate in the fetal waters.

ACC dosage for use

The daily dose for the treatment of cystic fibrosis in patients weighing more than 30 kg is used up to 800 mg. Children from the 10th day of life and up to 2 years old use 50 mg 2-3 r / s. At the age of 2-5 years - 400 mg per day, divided into 4 doses. From 6 years old - 600 mg / s (divided into 3 doses). Treatment is continued for a long time, courses for several months (3-6).

In all other cases, the daily dose for children from 14 years of age and adults is 400-600 mg. From 6 to 14 years - 300-400 mg (divided into 2 doses), 2-5 years - 200-300 mg (divided into 2 doses). Children from the 10th day of life and up to 2 years old use 50 mg 2-3 r / s. In acute diseases without complications, the product is prescribed for 5-7 days. In the case of the presence of complications or in the case of a chronic course, course treatment is possible (up to 6 months).

ACC is taken after a meal. The tablet or the contents of the sachet must be dissolved in half a glass of liquid (cold tea, water, juice).

ACC contraindications

Hypersensitivity to acetylcysteine ​​and excipients

peptic ulcer

hereditary fructose intolerance

Pulmonary bleeding or hemoptysis

In pediatric practice - with hepatitis and renal failure (the threat of accumulation of nitrogen-containing products).

ACC side effects

From the gastrointestinal tract - stomatitis, nausea, vomiting, diarrhea, heartburn.

From the side of the central nervous system - headache, tinnitus.

From the side of the CCC - arterial hypotension, increased heart rate.

Allergic reactions - bronchospasm (especially with bronchial hyperreactivity), rash and itching of the skin. Often the cause of hypersensitivity to the product is the presence of propyl and methyl parahydroxybenzoate in the composition.

ACC release form

ACC 100, 200 - effervescent tablets, 20 pcs.

ACC hot drink - powder for preparing a hot drink for internal use - 200 mg (20 sachets) and 600 mg (6 sachets).

ACC-long - effervescent tablets (600 mg), 10 pcs. in a tube.

ACC powder for solution for oral administration - 100, 200 mg, 2 pcs. in a pack.

ACC for children - powder for the preparation of a solution for oral administration 30 g in a 75 ml vial (20 mg / ml) and 60 g in a 150 ml vial (20 mg / ml).

ACC composition

Effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sucrose, saccharin, flavoring).

Powder: acetylcysteine ​​and auxiliary components (sucrose).

ACC Long effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sodium citrate, saccharin, sodium cyclamate, lactose, citric acid, sodium carbonate, mannitol, sodium bicarbonate, flavoring).

ACC for children: acetylcysteine.

ACC during pregnancy

There is no embryotoxic effect in acetylcysteine, however, during pregnancy, as well as during breastfeeding, it is prescribed only if there are indications under the supervision of a physician.

ACC interaction with other drugs

Tetracycline and its derivatives (except doxycycline) cannot be used together with ACC in pediatrics.

During experimental in vitro studies, there were no cases of inactivation of other types of antibacterial products. However, it is recommended to observe the interval between taking ACC and antibiotic at least 2 hours. In vitro, the incompatibility of acetylcysteine ​​with semi-synthetic penicillins, aminoglycoside and cephalosporin antibiotics has been proven. Such studies have not been conducted with erythromycin, amoxicillin and cefuroxime.

Simultaneous use of antitussive drugs can lead to stagnation of the secretion of the respiratory tract.

The use of nitroglycerin may enhance the vasodilating effect in the aftermath.

Medication synonym for ACC

No data..

ACC additional information

ACC is used with caution in gastric or duodenal ulcers.

When preparing a solution, a patient with bronchial asthma can inhale air with particles of the product, which causes irritation of the mucous membrane of the upper respiratory tract and can provoke reflex bronchospasm.

For the best mucolytic effect in the treatment with acetylcysteine, it is necessary to take a lot of liquid.

10 ml of the prepared oral solution contains 0.31 carbohydrate units, which should be taken into account for patients with diabetes.

Sorbitol has a slight laxative effect on the stool.

For newborns and children under 1 year of age, acetylcysteine ​​​​is used exclusively for health reasons under strict medical supervision. The recommended dosage (10 mg/kg body weight) must not be changed.

ACC 200 is not used at the age of up to 2 years.

The speed of reaction when driving and working with machinery does not change when taking acetylcysteine.