ACC is a mucolytic and expectorant for the treatment of cough in children: a guide for mothers. How does cough aid work and for what cough should it be used?

The most common problem that a child of any age can encounter is coughing.

Modern pharmaceuticals offer drugs aimed at combating this symptom in large quantities. ACC syrup occupies a leading place on this list.

This article presents instructions for using ACC cough syrup for children, average prices in pharmacies and reviews from parents about the children's medicine.

Description of the drug, composition, release form

Drug ACC - mucolytic syrup with anti-inflammatory effect. Produced in Germany and Slovenia.

The main active ingredient is acetylcysteine. Excipients - sodium benzoate, disodium edetate, saccharin, flavoring and water.

Solution has a viscous consistency and a pronounced cherry aroma.

Included in the set, a glass bottle of medicine is accompanied by a measuring cup and a syringe for dosing the drug.

When is it prescribed?

ACC is used to treat diseases that are accompanied by cough and difficult to clear sputum. When prescribing a medication for treatment, doctors focus on disturbing symptoms.

There may be an increase in body temperature, soreness in the throat and lungs. Present.

Indications for use of ACC:

ACC is prescribed in the initial stages of cough, when sputum does not separate on its own.

When listening to the child's breathing, wheezing and prolongation of inspiration are detected. The use of acetylcysteine-based products is most relevant.

Contraindications

Before taking, you should familiarize yourself with the contraindications of the drug:

diseases of the gastrointestinal tract;
age up to two years;
individual fructose intolerance;
allergic reaction to acetylcysteine.

Caution is important if the patient is diagnosed with varicose veins in the esophagus, kidney and liver disease, arterial hypertension, etc.

The use of the drug is strictly contraindicated for any type of bleeding, in particular from the respiratory tract.

How quickly does the effect appear?

The active ingredients of the medicinal solution are aimed at destroying the chemical composition of sputum cells. This reduces inflammation.

The cough becomes productive already on the 4-5th day of treatment. A week after starting treatment, significant improvements appear. Sometimes by this time the cough goes away completely.

For the correct dosage of the drug use a measuring syringe and cup included with the syrup.

100 mg of active ingredient is ¼ measuring cup. This volume will hold 5 ml of liquid. Accordingly, 200 mg is in half a glass, and 400 is in a full glass.

When dosing, take into account that the syringe holds 5 ml of the drug. For each age category there are restrictions on the amount of syrup.

In the interim from 2 to 6 years children can be given 5 ml of syrup, no more than 3 times a day. Aged from 6 to 14 years old 4 doses allowed. You can take 10 ml twice a day.

After 15 years the maximum daily dose is 30 ml. The number of appointments is prescribed by the doctor.

Methods of administration

Taking the drug involves following the algorithm of actions. First you need to measure out the required amount of syrup. The medicine is then given to the child in any convenient way.

As adults, children take medicine from a spoon without any problems. A younger child may resist taking it. A special syringe helps by injecting syrup into the baby’s mouth.

Terms of use medicine:

remove the protective cap and make a hole in the neck of the bottle;
draw the contents of the bottle into a syringe;
insert a syringe into the child’s cheek area;
Wash the syringe after use.

Children perceive taking the drug positively. The syrup has a pleasant taste and cherry aroma. But sometimes there are exceptions to this rule.

Interaction with other substances

Acetylcysteine is incompatible with other medicines for cough treatment. When taken simultaneously, sputum stagnation is possible, which delays treatment.

When prescribing ACC with antibiotics simultaneously maintain an interval of 2 hours between doses. Otherwise, the antibacterial effect may be reduced.

The exception is Loracarbef and Cefixime. It is not advisable to combine syrup with nitroglycerin. This is fraught with vasodilation.

Overdose and side effects

Side effects will not occur if you follow the dosage of the drug. If the dosage is exceeded, nausea, stool disturbances and pain in the abdominal area are noted.

The maximum daily amount of the drug is 500 mg per 1 kg of weight.

In case of overdose it is required gastric lavage and symptomatic therapy.

In case of individual intolerance components of the drug, Quincke's edema or shock may develop. But this rarely happens.

Price, analogues, shelf life

The cost of ACC in Russia is approximately 250 rubles. In some areas the price can reach 365 rubles.

There are similar drugs - these are , and Fluimucil.

The medicine should be stored out of the reach of children. The temperature should not exceed 25 degrees.

The shelf life of unopened syrup is 2 years.. Once opened, its shelf life is noticeably reduced - only 18 days.

Mucolytic drug.

Drug: ACC ®
Active substance: acetylcysteine
ATX code: R05CB01
KFG: Mucolytic drug
Reg. number: P No. 015474/01
Registration date: 01/13/05
Owner reg. cert.: HEXAL AG (Germany)

DOSAGE FORM, COMPOSITION AND PACKAGING

Granules for the preparation of solution for oral administration (orange) white, without agglomerates and mechanical impurities, with the smell of orange.

Excipients: ascorbic acid, saccharin, sucrose, orange flavor.

Granules for the preparation of solution for oral administration white, homogeneous, no more than 1.5 mm in size, without agglomerates and mechanical impurities, with the smell of lemon and honey.

Excipients: ascorbic acid, saccharin, sucrose, honey and lemon flavors.

3 g - sachets (6) - cardboard packs.
3 g - sachets (10) - cardboard packs.
3 g - sachets (20) - cardboard packs.

ACC ® 100

Effervescent tablets white, round, flat, with the smell of blackberries.

Excipients:

ACC ® 200

Effervescent tablets white, round, flat, scored, with the smell of blackberries.

Excipients: ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavor.

4 things. - strips (15) - cardboard boxes.
20 pcs. - aluminum tubes (1) - cardboard boxes.
20 pcs. - plastic tubes (1) - cardboard boxes.
25 pcs. - aluminum tubes (2) - cardboard boxes.
25 pcs. - plastic tubes (2) - cardboard boxes.
25 pcs. - aluminum tubes (4) - cardboard boxes.
25 pcs. - plastic tubes (4) - cardboard boxes.

ACC ® LONG

Effervescent tablets white, round, with a smooth surface, scored, with the smell of blackberries.

Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavoring "B".

6 pcs. - polypropylene tubes (1) - cardboard packs.
10 pieces. - polypropylene tubes (1) - cardboard packs.
20 pcs. - polypropylene tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACHOLOGIC EFFECT

Mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

PHARMACOKINETICS

Data on the pharmacokinetics of the ACC drug are not provided.

INDICATIONS

Respiratory diseases accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);

Acute and chronic sinusitis;

Otitis media

DOSING REGIME

Adults and teenagers over 14 years old it is recommended to prescribe the drug 200 mg 2-3 times a day (ACC 100 or ACC 200), or 200 mg 3 times a day (ACC in the form of granules for the preparation of a solution for oral administration 200 mg) or 600 mg 1 time / day (ACC LONG or ACC in the form of granules for the preparation of a solution for oral administration 600 mg).

Children aged 2 to 5 years The drug is recommended to be taken 100 mg 2-3 times a day (ACC 100 or ACC 200).

At cystic fibrosischildren over 6 years old the drug is recommended to be taken 200 mg 3 times a day (ACC 100, ACC 200 or ACC in the form of granules for the preparation of an oral solution of 200 mg). Children aged 2 to 6 years- 100 mg 4 times/day (ACC 100 or ACC 200). Patients with body weight more than 30 kg for cystic fibrosis, if necessary, you can increase the dose to 800 mg/day.

At sudden short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Effervescent tablets (ACC 100 and ACC 200) should be dissolved in 1/2 glass of water, effervescent tablets (ACC LONG) should be dissolved in 1 glass of water. Take immediately after dissolution; in exceptional cases, you can leave the prepared solution for 2 hours.

Granules for preparing a hot drink (1 sachet) are dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Granules for oral solution (orange scent) should be dissolved in water, juice or iced tea and taken after meals.

SIDE EFFECT

From the side of the central nervous system: rarely - headaches, tinnitus.

From the digestive system: rarely - stomatitis; in some cases - diarrhea, vomiting, heartburn and nausea.

From the cardiovascular system: in some cases - a drop in blood pressure, tachycardia.

From the respiratory system: in isolated cases - the development of pulmonary hemorrhage as a manifestation of a hypersensitivity reaction.

Allergic reactions: in isolated cases - bronchospasm (mainly in patients with a hyperreactive bronchial system with bronchial asthma), skin rash, itching and urticaria.

CONTRAINDICATIONS

Peptic ulcer of the stomach and duodenum in the acute phase;

Hemoptysis;

Pulmonary hemorrhage;

Pregnancy;

Lactation period (breastfeeding);

Children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration 200 mg);

Children under 14 years of age (dosage forms containing acetylcysteine 600 mg);

Hypersensitivity to acetylcysteine and other components of the drug.

WITH caution the drug should be used in patients with varicose veins of the esophagus, with an increased risk of developing pulmonary hemorrhage and hemoptysis, with bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure.

ACC LONG should not be prescribed to children under 14 years of age. In this category of patients, it is recommended to use oral dosage forms with a lower acetylcysteine content.

PREGNANCY AND LACTATION

Due to insufficient data, the use of the drug during pregnancy and lactation is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child.

SPECIAL INSTRUCTIONS

For bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systematic monitoring of bronchial patency.

If side effects develop, you should stop taking the drug.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

1 effervescent tablet ACC 100 and ACC 200 corresponds to 0.006 XE.

1 effervescent tablet ACC LONG corresponds to 0.01 XE.

ACC (in the form of granules for the preparation of an oral solution of 200 mg) corresponds to 0.21 XE, ACC (in the form of granules for the preparation of an oral solution of 600 mg) - 0.17 XE.

ACC (in granules for the preparation of a solution for oral administration 100 mg and 200 mg with the scent of orange) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Use in pediatrics

OVERDOSE

Symptoms: Possible diarrhea, vomiting, stomach pain, heartburn, nausea.

Treatment: carrying out symptomatic therapy.

DRUG INTERACTIONS

With the simultaneous use of acetylcysteine and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution).

When taking acetylcysteine and nitroglycerin simultaneously, the vasodilatory effect of nitroglycerin may be enhanced.

There is a synergism between acetylcysteine and bronchodilators.

Pharmaceutical interactions

Acetylcysteine is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

When acetylcysteine comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is approved for use as a means of OTC.

CONDITIONS AND DURATION OF STORAGE

The drug should be stored in a dry place, out of reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years, shelf life of granules for preparing an oral solution (orange scent) - 4 years.

ACC LONG should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 30°C. Shelf life - 3 years.

After taking the tablet, the tube should be tightly closed.

Children's immunity develops gradually. This is the reason for special susceptibility to colds. One of the most unpleasant symptoms of a cold is a cough.

It can be dry and wet. A dry cough causes pain and discomfort in the throat area. To treat it, ACC powder is prescribed for children.

This article discusses the instructions for using ACC powder (100 and 200 mg) for children, collects reviews from parents about the children's medicine, and indicates the price of the drug.

Composition and pharmacological properties

ACC is a medical drug to combat. Produced in Germany and Slovenia. Has expectorant and anti-inflammatory effects.

The main active ingredient of the drug is acetylcysteine. Auxiliary components are sodium saccharinate, ascorbic acid, sucrose and flavoring.

The drug is available in tablet and powder format. The second option is prescribed in childhood.

The drug package contains 20 packets of granules. They have white color and pleasant aroma. Depending on the additive, it can be lemon, orange or honey.

ACC gives an expectorant effect. It is also prescribed when purulent type of sputum occurs.

It is possible to use the drug for preventive purposes, for chronic diseases of the respiratory system.

Indications

ACC powder is prescribed for any types of diseases accompanied by the release of sputum in the pulmonary tract.

The drug allows you to make your cough more productive. The active component reduces the inflammatory process, making the child feel better.

Indications specified in the instructions for the medicine:

Before prescribing the drug, The doctor should listen to the child's breathing with a stethoscope.

In the presence of viscous and thick sputum, exhalation will be prolonged, and breathing will be heavy, with moist wheezing.

Contraindications

Prescription of drug dosage in the presence of diseases of the gastrointestinal tract carried out with caution.

In case of individual histamine intolerance, long-term use of ACC is not recommended.

Doctors advise use ACC with caution when tendency to varicose veins in the esophagus.

In case of renal or liver failure during treatment, it is necessary to monitor the condition of the organs through testing.

Direct contraindications to taking medicinal granules:

bleeding in the lung area;
presence of sensitivity to the components of the drug;
acute form of gastrointestinal diseases;
age up to 2 years;
fructose intolerance.

How quickly it helps

Active component of the drug has mucus thinning properties using the process of depolymerization of mucoproteins.

The antioxidant effect is based on the ability to bind to oxidative radicals, eliminating their viability. The intensity of the inflammatory process decreases.

The process of metabolism of the active substances of the drug is carried out in the liver. The maximum concentration of components in blood cells is reached approximately 2 hours after administration. The elimination process is carried out by the kidneys.

Sputum discharge is noted on the first day of use. medicine.

Complete disappearance of the cough reflex occurs after a full course of treatment. Its duration depends on the severity of the disease.

Dosage - 100 or 200 mg

How to drink ACC powder for children? Mucolytic therapy involves following the dosage prescribed by the doctor.

Ages 2 to 6 years It is allowed to take 100 mg of the drug no more than 3 times a day. Ages 6 to 14 single dose - 200 mg. But the number of receptions remains the same.

Daily dose for adolescents over 14 years of age is 400-600 mg of the drug per day. This amount is spread over 2 doses.

In severe cases of the disease, the dosage is increased. If the child’s body weight exceeds 30 kg, then the daily dose of the drug can reach 800 mg.

How to dilute and take, special instructions

Before use ACC powder must be dissolved in hot water. For 100 mg of the drug you will need 100 ml of liquid.

The resulting ACC solution (suspension) for children taken orally, hot, regardless of food.

Without supervision by medical representatives the drug can be used for no longer than 5 days. In case of complications of the disease, the course of treatment is extended. But this nuance is discussed with the attending physician.

If you have diabetes mellitus, ACC should be used with caution.. The composition of the drug includes sucrose. This is taken into account when prescribing dosage.

Possibility of combination with other substances

Combining ACC powder with agents of a similar effect can lead to stagnation of mucus in the respiratory organs.

Simultaneous use with antibiotics such as tetracycline, penicillin and cephalosporin is undesirable. Acetylcysteine reduces the antibacterial effect of these components.

ACC increases the vasodilatory effect of nitroglycerin, therefore it is advisable to reduce its dosage.

Any combination of ACC with medications is discussed with a pediatrician to prevent possible side effects.

Overdose and side effects

Overdose is possible during treatment Therefore, you should follow the dosage regimen prescribed by your doctor.

Exceeding the dosage is fraught with the appearance of characteristic symptoms. These include stomach pain, stool disturbances, nausea, and heartburn.

In this case, gastric lavage is indicated. You should remain in bed and stop using the drug.

The drug is not classified as a prescription drug. In the Russian Federation, ACC powder can be purchased at any pharmacy.

There are two packaging volume options - 100 and 200 mg. The package contains 20 serving packets.

The cost of a medicine with a dosage of 100 mg is 130 rubles. In some areas it reaches 150 rubles. The average price of a package with a dosage of 200 mg is 180 rubles.

The optimal storage temperature should not exceed 25 degrees. The powder package should be stored in a place protected from light.

Shelf life is 4 years from the date of release. After its expiration, it is prohibited to use the drug.

Among the mucolytic drugs prescribed for coughs, the drug ACC, produced by the Sandoz company, is in great demand. Can it be used in the treatment of children and at what age is it permissible to give ACC to children? Which dosage form is best to choose for children? How to dilute a tablet or granules? These and other questions about the use of such a medicine concern every mother if the doctor prescribed this drug to her coughing child.

Release form

The ACC drug is presented in the following forms:

Effervescent tablets. They are distinguished by their flat round shape, blackberry scent and white color, and the active ingredient content of each soluble tablet is 100 or 200 mg. Tablets with 600 mg of the active compound, called ACC long, are also produced. One tube contains 10-20 tablets.
Syrup. The packaging of this ACC is a glass bottle filled with 100 ml of a clear, viscous, colorless liquid with a cherry aroma. 1 ml of syrup contains 20 mg of the active ingredient.
Packets of granules. The weight of one bag is 3 grams, and one pack includes 20 bags, inside of which there is a white, homogeneous granular powder. The drink made from it may taste like orange or lemon with honey. The content of the active component in the package is 100 mg or 200 mg.
Solution. This medicine, called ACC injection, is a clear liquid without any color, poured into 3 ml ampoules. One ampoule contains 300 mg of active substance. One package includes 5 ampoules.

Compound

The main ingredient of any form of ACC, which provides the drug with a therapeutic effect, is acetylcysteine. Excipients in different types of medicine differ:

Effervescent tablets contain citric and ascorbic acid, bicarbonate, saccharin, citrate and sodium carbonate. This form also contains milk sugar and mannitol, and blackberry flavoring gives the tablet and the solution prepared from it a pleasant smell.
The auxiliary ingredients of the ACC powder form are sucrose and ascorbic acid. This medicine also contains saccharin, and the presence of flavoring makes the drink made from granules orange or lemon-honey.
Additional substances in the syrup are represented by water, methyl parahydroxy benzoate, disodium edetate, as well as sodium hydroxide, carmellose, benzoate and saccharinate. The smell of this medicine is given by cherry flavoring.
In addition to the active substance, the ACC injection solution contains sterile water and disodium edetate. This liquid form also contains ascorbic acid and sodium hydroxide.

Operating principle

After entering the human body, acetylcysteine begins to directly affect the sputum formed in the respiratory tract. In particular, this compound changes the rheology of mucus due to the destruction of bonds in mucopolysaccharides that are found in bronchial secretions. This thins the mucus and reduces its viscosity. The effectiveness of the product does not decrease, even if pus is mixed with the mucus.

Acetylcysteine also has some antioxidant activity. It is noted that this substance stimulates the synthesis of glutathione and is also capable of neutralizing radicals formed during oxidative processes. This action of ACC strengthens the protection of cells in the respiratory tract mucosa and also helps reduce the inflammatory process.

Indications

The reason to use ACC is any disease of the respiratory system, in which too viscous secretions have accumulated inside the bronchial tree.

The drug is prescribed for:

Laryngitis.
Bronchitis.
Pneumonia.
Laryngotracheitis.
Chronic pulmonary pathologies, including diseases occurring with obstruction.
Bronchiolitis.
Bronchiectasis.
Development of an abscess in the lung.

ENT doctors prescribe this medication for otitis media, rhinitis or sinusitis. ACC also helps with cystic fibrosis.

At what age can it be given?

The instructions for use allow the use of ACC for children over 2 years of age. For young patients aged from two to 5 years, a medicine called ACC 100 is intended, since the dosage of the active substance in it is the lowest. The drugs ACC 200 and ACC injection are prescribed to children six years of age and older. A medication with a maximum dosage of acetylcysteine (ACC long) is recommended from the age of 14.

Contraindications

Annotation for ACC drugs prohibits their use in the following cases:

If a child is found to be intolerant to some component of the medication, for example, acetylcysteine or lactose, which is included in the tablets.
If the lung disease is complicated by bleeding and traces of blood are found in the sputum.
If the patient has a peptic ulcer.
If the child suffers from a lack of certain enzymes (lactase, sucrase) or impaired carbohydrate metabolism.

Without consulting a doctor, ACC should not be given to children with bronchial asthma, arterial hypertension, kidney disease, liver pathologies, adrenal gland dysfunction, or diabetes mellitus. For such diseases, the pediatrician first evaluates the indications, and then selects the desired form of ACC and the correct dosage of the drug.

Side effects

Like many other medications, ACC can cause allergies. Taking this medication may cause hives, swelling of the skin, itching, rashes, and even anaphylactic shock.

Other side effects of ACC include:

Shortness of breath or the appearance of bronchospasm. This reaction of the child’s body to acetylcysteine is often found in bronchial asthma. If your child's cough worsens after taking ACC, you should consult a doctor immediately.
Heartburn, loose stools, discomfort in the stomach and other symptoms called dyspepsia.
Increased body temperature, headache, noise in the ear, bleeding. Such negative effects of ACC treatment are very rare.

Instructions for use

How to use

The use of ACC is recommended after meals.
An effervescent tablet in the required dose should be placed in a glass of water, wait until it dissolves, and then offer the medicine to the child. For dissolution, use only water and glassware.
The contents of ACC portioned sachets are dissolved in half a glass of liquid. In this case, the granules can be diluted with water or another drink, for example, juice or cooled tea.
It is not advisable to leave the ACC suspension prepared from tablets or powder for a long time. If it is not possible to drink the medicinal solution immediately, storage at room temperature for no longer than two hours is permissible.
To dose the syrup, it is recommended to use a measuring cup or syringe, which is placed in the medicine package.
The last dose of ACC should not be later than 18 hours, since later use may adversely affect sleep.
In order for the therapeutic effect of the drug to occur faster, additional consumption of a large volume of liquid is recommended.
The doctor decides how many days to take the medicine individually for each child. In case of acute illness, the duration of use is most often 5-7 days.
ACC injections are given in the hospital 1-2 times a day. The drug is injected either deep into the muscle or slowly into a vein (over 5 minutes), mixing the contents of the ampoule with saline or glucose in a 1 to 1 ratio.

Dosage

The daily dose of ACC, regardless of the form of release, for a child of different ages will be as follows:

This dose is divided into 2 doses for children under 14 years of age, and a child over 14 years of age can be given the drug either once a day or divided into 2-3 doses.

A single dose of various forms of ACC for a child over 2 years of age up to 6 years of age is usually 100 mg of acetylcysteine.

A child of this age is prescribed one of the following medications:

A single dosage for children over 6 years of age and up to 14 years of age will be 150-200 mg of acetylcysteine. Often the drug is prescribed in a dosage of 200 mg per dose.

Depending on the form of ACC, this will be the following amount of medicine:

The ACC solution in ampoules can also be used for inhalation in a nebulizer. For one procedure, take 3 ml of medication and mix it with 3 ml of saline solution. This manipulation is allowed for coughs in children over 12 years of age.

Overdose

Taking too much ACC may cause vomiting, severe nausea, or loose stools. To help with an overdose, the doctor prescribes symptomatic treatment.

Interaction with other drugs

It is not recommended to mix ACC and any other drugs in one glass.
The use of sorbents, for example, activated carbon, will reduce the effectiveness of acetylcysteine treatment.
It is strictly forbidden to give children ACC and medications that suppress the cough reflex. This combination of medications can cause stagnation of mucus in the respiratory tract.
If you combine ACC and medications from the bronchodilator group, the treatment of cough will be more effective.
Acetylcysteine may worsen the effect of antibiotic therapy if cephalosporins or penicillin drugs are used, and therefore a break of 2 hours or more should be allowed between such drugs.
The simultaneous administration of ACC and vasodilating drugs leads to greater vasodilation.

Terms of sale

To purchase any form of ACC, except for injection, you do not need to present a prescription. To purchase ACC injection, you will need a prescription from a doctor.

On average, the cost of a pack of 20 ACC 100 tablets or one bottle of syrup is about 240 rubles. The price of ACC in bags is approximately 120-130 rubles per package. For ten tablets ACC Long

HEXAL HEXAL/ Salutas Pharma GmbH Hexal AG Hermes Arzneimittel GmbH/ Salutas Pharma GmbH Hermes Pharma Ges. M.b.H./ Salutas Pharma GmbH Lindopharm GmbH/Salutas Pharma GmbH OTHERS Salutas Pharma GmbH Salutas Pharma GmbH/Hexal AG Pharma Wernigerode GmbH/Salutas Pharma GmbH EVER Pharma Jena GmbH/Salutas Pharma GmbH

Country of origin

Austria/Germany Germany Russia Slovenia

Product group

Respiratory system

Mucolytic (expectorant) agent.

Release forms

10 pieces. - polypropylene tubes (1) - cardboard packs. 20 pcs. - polypropylene tubes (1) - cardboard packs. 3 ml - dark glass ampoules (5) - cardboard packs 3 ml - dark glass ampoules (5) - cardboard packs. 3 ml - dark glass ampoules (50) - cardboard packs. 3 ml - dark glass ampoules (100) - cardboard packs. 30 g (for preparing 75 ml of syrup) - dark glass bottles (1) complete with a measuring spoon - cardboard packs. 60 g (for preparing 150 ml of syrup) - dark glass bottles (1) complete with measures Granules for preparing a solution for oral administration, 3 g - sachets - 20 pcs per pack. Granules for preparing a solution for oral administration, 3 g each - sachets - 20 pcs per pack. Syrup 100 ml - bottles complete with a measuring cup and syringe - cardboard packs. Syrup 200 ml in bottles. Dosing devices: transparent measuring cup (cap), graduated to 2.5, 5 and 10 ml; transparent dosing syringe, graduated at 2.5 and 5 ml with a white piston and an adapter ring for attaching to the bottle. Effervescent tablets - 20 pcs per pack. Effervescent tablets - 20 pcs per pack. pack 10 tablets pack 6 sachets of 3.0g

Description of the dosage form

transparent, colorless, slightly viscous solution with a cherry odor. Granules for the preparation of a solution for oral administration Granules for the preparation of a solution for oral administration (orange) are white, homogeneous, without agglomerates, with the smell of orange. Granules for the preparation of a solution for oral administration are white, homogeneous, no more than 1.5 mm in size, without agglomerates and mechanical impurities, with the smell of lemon and honey. Granules for making syrup are white to yellowish in color, homogeneous, without agglomerated particles, with the smell of orange. Solution for injection The syrup is clear, colorless, slightly viscous, with a cherry odor. Effervescent tablets Effervescent tablets are white, round, flat, with the smell of blackberries. Effervescent tablets are white, round, flat, scored, with a blackberry scent. Effervescent tablets are white, round, chamfered, scored on one side, with a smooth surface, with the smell of blackberries; When 1 tablet is dissolved in 100 ml of water, a colorless transparent solution with a blackberry odor is obtained. Effervescent tablets

pharmachologic effect

Acetylcysteine is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum. It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (577 group) to bind to oxidative radicals and thus neutralize them. In addition, acetylcysteine promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction. With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Absorption is high. They are quickly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1 - 3 hours. The connection with blood plasma proteins is 50%. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). The half-life (Ti/2) is about 1 hour, impaired liver function leads to an extension of Ti/2 to 8 hours. Penetrates the placental barrier. There are no data on the ability of acetylcysteine to penetrate the blood-brain barrier and be excreted in breast milk.

Special conditions

For bronchial asthma and obstructive bronchitis, acetylcysteine should be prescribed with caution under systematic monitoring of bronchial patency. If side effects develop, you should stop taking the drug. When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances. 1 effervescent tablet ACC 100 and ACC 200 corresponds to 0.006 XE. 1 effervescent tablet ACC LONG corresponds to 0.01 XE. ACC (in the form of granules for the preparation of an oral solution of 200 mg) corresponds to 0.21 XE, ACC (in the form of granules for the preparation of an oral solution of 600 mg) - 0.17 XE. ACC (in granules for the preparation of a solution for oral administration 100 mg and 200 mg with the scent of orange) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE. Use in pediatrics Children under 6 years of age are recommended to prescribe the drug in dosage forms with a lower content of acetylcysteine.

Compound

1 ml acetylcysteine 20 mg Excipients: methyl parahydroxybenzoate - 1.3 mg, sodium benzoate - 1.95 mg, disodium edetate - 1 mg, sodium saccharinate - 1 mg, sodium carmellose - 2 mg, sodium hydroxide (10% aqueous solution) - 30-70 mg , Cherry flavoring - 1.5 mg, purified water - 910.25-950.25 mg. 1 pack acetylcysteine 100 mg Excipients: sucrose - 2829.5 mg, ascorbic acid - 12.5 mg, saccharin - 8 mg, orange flavor - 50 mg. 1 tab. acetylcysteine 600 mg Excipients: citric acid - 625 mg, sodium bicarbonate - 327 mg, sodium carbonate - 104 mg, mannitol - 72.8 mg, lactose - 70 mg, ascorbic acid - 75 mg, sodium cyclamate - 30.75 mg, sodium saccharinate dihydrate - 5 mg, sodium citrate dihydrate - 0.45 mg, blackberry flavor "B" - 40 mg. Acetylcysteine 100 mg Excipients: ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavoring "B". Acetylcysteine 100 mg 300 mg Excipients: disodium edetate, sodium hydroxide, ascorbic acid, water for injection. acetylcysteine 100 mg/5ml of finished syrup Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, sorbitol, sodium citrate, orange flavor. acetylcysteine 100 mg/ml Excipients: disodium edetate, sodium hydroxide, ascorbic acid, water for injection. Acetylcysteine 200 mg Excipients: ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavoring "B". Acetylcysteine 200 mg Excipients: ascorbic acid, saccharin, sucrose (sucrose), orange flavor. Acetylcysteine 200 mg Excipients: ascorbic acid, saccharin, sucrose (sucrose), lemon and honey flavors. Acetylcysteine 600 mg Excipients: ascorbic acid, saccharin, sucrose (sucrose), lemon and honey flavors. Acetylcysteine 600 mg Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavoring "B". acetylcysteine 600 mg Excipients Citric acid (625.00 mg), sodium bicarbonate (327.00 mg), sodium carbonate (104.00 mg), mannitol (72.80 mg), lactose (70.00 mg), ascorbic acid (75.00 mg), sodium cyclamate (30.75 mg), sodium saccharinate dihydrate (5.00 mg), sodium citrate dihydrate (0.45 mg), blackberry flavor “B” (40.00 mg).

ACC indications for use

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, tracheitis due to bacterial and/or viral infection, pneumonia, bronchiectasis, bronchial asthma, atelectasis due to blockage of the bronchi with a mucus plug, sinusitis (to facilitate the passage of secretions ), cystic fibrosis (as part of combination therapy). Removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions. Paracetamol overdose.

ACC contraindications

- peptic ulcer of the stomach and duodenum in the acute phase; - hemoptysis; - pulmonary hemorrhage; - pregnancy; - lactation period (breastfeeding); - children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration 200 mg); - children under 14 years of age (dosage forms containing acetylcysteine 600 mg); - hypersensitivity to acetylcysteine and other components of the drug. The drug should be used with caution in patients with varicose veins of the esophagus, with an increased risk of developing pulmonary hemorrhage and hemoptysis, with bronchial asthma, diseases of the adrenal glands, liver and/or kidney failure. ACC LONG should not be prescribed to children under 14 years of age. In this category of patients, it is recommended to use oral dosage forms with a lower acetylcysteine content.

ACC dosage

100 mg 100 mg/5 ml 200 mg 200, 600 mg; 100, 200 mg 300 mg/3ml 600 mg

ACC side effects

According to the World Health Organization (WHO), adverse reactions are classified according to their frequency of development as follows: very common (>1/10), common (>1/100, 1/1000, 1/10000,

Drug interactions

With the simultaneous use of acetylcysteine and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution). When taking acetylcysteine and nitroglycerin simultaneously, the vasodilatory effect of nitroglycerin may be enhanced. There is a synergism between acetylcysteine and bronchodilators. Acetylcysteine increases the synthesis of glutathione, which promotes the detoxification of harmful substances. This explains the effect of acetylcysteine as an antidote for paracetamol poisoning. Pharmaceutical interactions When acetylcysteine is taken simultaneously with antibiotics (penicillins, ampicillins, cephalosporins, erythromycin, some tetracyclines and amphotericin B), physical and chemical incompatibility or their inactivation occurs. Therefore, these antibiotics cannot be administered in the same solution with acetylcysteine.

Overdose

In case of an erroneous or deliberate overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed. To date, no severe or life-threatening side effects have been observed. Treatment: symptomatic.

Storage conditions

store in a dry place
store at room temperature 15-25 degrees
keep away from children
store in a place protected from light

Information provided by the State Register of Medicines.

Synonyms

Acetylcysteine, ACC 100, ACC 200, ACC-Long, Mukonex, Fluimucil, Exomyuk 200, N-AC-Ratiopharm