ACC 200 sachets instructions for use. Drug "ACC": indications

Children's immunity develops gradually. This is the reason for special susceptibility to colds. One of the most unpleasant symptoms of a cold is a cough.

It can be dry and wet. A dry cough causes pain and discomfort in the throat area. To treat it, ACC powder is prescribed for children.

This article discusses the instructions for using ACC powder (100 and 200 mg) for children, collects reviews from parents about the children's medicine, and indicates the price of the drug.

Composition and pharmacological properties

ACC is a medical drug to combat. Produced in Germany and Slovenia. Has expectorant and anti-inflammatory effects.

The main active ingredient of the drug is acetylcysteine. Auxiliary components are sodium saccharinate, ascorbic acid, sucrose and flavoring.

The drug is available in tablet and powder format. The second option is prescribed in childhood.

The drug package contains 20 packets of granules. They have white color and pleasant aroma. Depending on the additive, it can be lemon, orange or honey.

ACC gives an expectorant effect. It is also prescribed when purulent type of sputum occurs.

It is possible to use the drug for preventive purposes, for chronic diseases of the respiratory system.

Indications

ACC powder is prescribed for any types of diseases accompanied by the release of sputum in the pulmonary tract.

The drug allows you to make your cough more productive. The active component reduces the inflammatory process, making the child feel better.

Indications specified in the instructions for the medicine:

Before prescribing the drug, The doctor should listen to the child's breathing with a stethoscope.

In the presence of viscous and thick sputum, exhalation will be prolonged, and breathing will be heavy, with moist wheezing.

Contraindications

Prescription of drug dosage in the presence of diseases of the gastrointestinal tract carried out with caution.

In case of individual histamine intolerance, long-term use of ACC is not recommended.

Doctors advise use ACC with caution when tendency to varicose veins in the esophagus.

In case of renal or liver failure during treatment, it is necessary to monitor the condition of the organs through testing.

Direct contraindications to taking medicinal granules:

• bleeding in the lung area;
• presence of sensitivity to the components of the drug;
• acute form of gastrointestinal diseases;
• age up to 2 years;
• fructose intolerance.

How quickly it helps

Active component of the drug has mucus thinning properties using the process of depolymerization of mucoproteins.

The antioxidant effect is based on the ability to bind to oxidative radicals, eliminating their viability. The intensity of the inflammatory process decreases.

The process of metabolism of the active substances of the drug is carried out in the liver. The maximum concentration of components in blood cells is reached approximately 2 hours after administration. The elimination process is carried out by the kidneys.

Sputum discharge is noted on the first day of use. medicine.

Complete disappearance of the cough reflex occurs after a full course of treatment. Its duration depends on the severity of the disease.

Dosage - 100 or 200 mg

How to drink ACC powder for children? Mucolytic therapy involves following the dosage prescribed by the doctor.

Ages 2 to 6 years It is allowed to take 100 mg of the drug no more than 3 times a day. Ages 6 to 14 single dose - 200 mg. But the number of receptions remains the same.

Daily dose for adolescents over 14 years of age is 400-600 mg of the drug per day. This amount is spread over 2 doses.

In severe cases of the disease, the dosage is increased. If the child’s body weight exceeds 30 kg, then the daily dose of the drug can reach 800 mg.

How to dilute and take, special instructions

Before use ACC powder must be dissolved in hot water. For 100 mg of the drug you will need 100 ml of liquid.

The resulting ACC solution (suspension) for children taken orally, hot, regardless of food.

Without supervision by medical representatives the drug can be used for no longer than 5 days. In case of complications of the disease, the course of treatment is extended. But this nuance is discussed with the attending physician.

If you have diabetes mellitus, ACC should be used with caution.. The composition of the drug includes sucrose. This is taken into account when prescribing dosage.

Possibility of combination with other substances

Combining ACC powder with agents of a similar effect can lead to stagnation of mucus in the respiratory organs.

Simultaneous use with antibiotics such as tetracycline, penicillin and cephalosporin is undesirable. Acetylcysteine ​​reduces the antibacterial effect of these components.

ACC increases the vasodilatory effect of nitroglycerin, therefore it is advisable to reduce its dosage.

Any combination of ACC with medications is discussed with a pediatrician to prevent possible side effects.

Overdose and side effects

Overdose is possible during treatment Therefore, you should follow the dosage regimen prescribed by your doctor.

Exceeding the dosage is fraught with the appearance of characteristic symptoms. These include stomach pain, stool disturbances, nausea, and heartburn.

In this case, gastric lavage is indicated. You should remain in bed and stop using the drug.

The drug is not classified as a prescription drug. In the Russian Federation, ACC powder can be purchased at any pharmacy.

There are two packaging volume options - 100 and 200 mg. The package contains 20 serving packets.

The cost of a medicine with a dosage of 100 mg is 130 rubles. In some areas it reaches 150 rubles. The average price of a package with a dosage of 200 mg is 180 rubles.

The optimal storage temperature should not exceed 25 degrees. The powder package should be stored in a place protected from light.

Shelf life is 4 years from the date of release. After its expiration, it is prohibited to use the drug.

Instructions
on the use of a medicinal product for medical use

Registration number:

P N015473/01-180914

Trade name of the drug:

International nonproprietary name:

acetylcysteine.

Dosage form:

effervescent tablets.

Compound:

1 effervescent tablet contains:
active substance: acetylcysteine ​​– 200.00 mg; Excipients: anhydrous citric acid – 558.50 mg; sodium bicarbonate – 200.00 mg; sodium carbonate anhydrous – 100.00 mg; mannitol – 60.00 mg; anhydrous lactose – 70.00 mg; ascorbic acid – 25.00 mg; sodium saccharinate – 6.00 mg; sodium citrate – 0.50 mg; blackberry flavor “B” – 20.00 mg.

Description: round, flat-cylindrical, white tablets with a score on one side, with a blackberry flavor. There may be a faint sulfuric odor.
Reconstituted solution: colorless transparent solution with the smell of blackberries. There may be a faint sulfuric odor.

ATX code: R05СВ01.

Pharmacological properties

Pharmacodynamics
Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.
It has an antioxidant effect based on the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.
In addition, acetylcysteine ​​promotes the synthesis of glutathione, an important component of the antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations of bacterial etiology in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics
Absorption is high. They are quickly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides. Bioavailability when taken orally is 10% (due to the presence of a pronounced “first pass” effect through the liver). The time to reach the maximum concentration (Cmax) in the blood plasma is 1-3 hours. The connection with blood plasma proteins is 50%. Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine).
The half-life (T1/2) is about 1 hour, liver dysfunction leads to an extension of T1/2 to 8 hours. Penetrates the placental barrier.
There are no data on the ability of acetylcysteine ​​to penetrate the blood-brain barrier and be excreted in breast milk.

Indications for use

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum:
acute and chronic bronchitis, obstructive bronchitis;
tracheitis, laryngotracheitis;
pneumonia;
lung abscess;
bronchiectasis, bronchial asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis;
cystic fibrosis;
Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Contraindications:

Hypersensitivity to acetylcysteine ​​or other components of the drug;
peptic ulcer of the stomach and duodenum in the acute stage;
pregnancy;
breastfeeding period;
hemoptysis, pulmonary hemorrhage;
lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
children under 2 years of age (for this dosage form).

Carefully: history of gastric and duodenal ulcers, bronchial asthma, obstructive bronchitis, liver and/or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching), varicose veins of the esophagus, diseases of the adrenal glands, arterial hypertension.

Use during pregnancy and breastfeeding

Data on the use of acetylcysteine ​​during pregnancy and breastfeeding are limited, therefore the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during breastfeeding, the issue of stopping it should be decided.

Directions for use and doses

Inside, after eating.
Effervescent tablets should be dissolved in one glass of water. The tablets should be taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect against infections.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy:
adults and children over 14 years old: 1 effervescent tablet 2-3 times a day (400-600 mg);
children from 6 to 14 years old: 1 effervescent tablet 2 times a day (400 mg);
children from 2 to 6 years old: 1/2 effervescent tablet 2-3 times a day (200-300 mg).
Cystic fibrosis:
children from 2 to 6 years old: 1/2 effervescent tablet 4 times a day (400 mg);
children over 6 years old: 1 effervescent tablet 3 times a day (600 mg).

Side effect

According to the World Health Organization (WHO), adverse effects are classified according to their frequency as follows: very common (≥ 1/10), common (≥ 1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
Allergic reactions
infrequently: skin itching, rash, exanthema, urticaria, angioedema, decreased blood pressure, tachycardia;
very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the respiratory system
rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
From the gastrointestinal tract
infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.
Sensory disorders
infrequently: noise in ears.
Others
infrequently: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.

Overdose

Symptoms: In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.
Treatment: symptomatic.

Interaction with other drugs

With the simultaneous use of acetylcysteine ​​and antitussives due to suppression of the cough reflex, sputum stagnation may occur.
When used simultaneously with antibiotics for oral administration (penicillins, tetracyclines, cephalosporins, etc.) they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbene).
Simultaneous use with vasodilating agents And nitroglycerin may lead to increased vasodilatory effects.

special instructions

Instructions for patients with diabetes mellitus
1 effervescent tablet corresponds to 0.006 XE. When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.
Severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes occur in the skin and mucous membranes, you should immediately consult a doctor and stop taking the drug.
In patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systemic monitoring of bronchial patency.
You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Impact on the ability to drive vehicles and machinery

There is no data on the negative effect of the drug ACC ® 200 in recommended doses on the ability to drive vehicles or use machinery.

Special precautions when disposing of unused medicinal product

There is no need for special precautions when disposing of unused ACC ® 200.
Close the tube tightly after taking the tablet!

Release form

When packaging Hermes Pharma Ges.m.b.H., Austria:
Primary packaging
20 or 25 effervescent tablets in a plastic tube.
Secondary packaging
1 tube of 20 effervescent tablets or 2 or 4 tubes of 25 effervescent tablets along with instructions for use in a cardboard box.
When packaging Hermes Arzneimittel GmbH, Germany
Primary packaging
4 effervescent tablets in strips made of three-layer material: paper/polyethylene/aluminium.
Secondary packaging
15 strips along with instructions for use in a cardboard box.

Storage conditions

In a dry place at a temperature not exceeding 25°C.
Keep out of the reach of children.

Best before date

3 years.
Do not use after expiration date.

Vacation conditions

Over the counter.

Manufacturer

Holder of RU: Sandoz d.d., Verovshkova 57, 1000 Ljubljana, Slovenia;

Produced:
1. Hermes Pharma Ges.m.b.H., Austria;
2. Hermes Arzneimittel GmbH, Germany.

Consumer complaints should be sent to Sandoz CJSC:
123317, Moscow, Presnenskaya embankment, 8, building 1.

Mucus, which has become less viscous, is evacuated much more easily and quickly from the breathing tubes, making room for air and a renewed mucous layer.

Among the drugs that can produce such an effect on bronchial sputum, ACC 200 powder is very popular. Instructions for use of water-soluble granules describe how to use this secretolytic and provide other important information about the medication.

Composition of ACC in sachets

Soluble ACC (powder) 200 in the form of small granular particles is packaged in sachets of 200 mg, each of which contains:

• acetylcysteine ​​(active ingredient);
• additional ingredients - ascorbic acid, citrus and honey flavors, sucrose, saccharin.

The small granules look like a white or yellowish powder with a distinct honey and citrus odor.

Mechanism of action

According to the pharmacological action, ACC (powder) 200 mg belongs to the group of mucolytic expectorants that exhibit a mucolytic effect, facilitating the evacuation of sputum.

These effects are achieved by the direct effect of acetylcysteine ​​on the rheological qualities (“fluidity”) of bronchial mucus. Acetylcysteine ​​is effective even in the presence of pus in the sputum.

Method of use for cough

The instructions for using ACC granules list several pathologies accompanied by a cough reflex when the use of this powder is appropriate:

How to dilute ACC in granules to prepare a solution from 200 mg of powder is written in the instructions for use of the drug.

Instructions for use

Before diluting ACC 200 powder, you should first familiarize yourself with the rules for using this medication, because compliance with the dosage and timing of use is the most important component for successful treatment.

How to breed?

There is no special technology in how to dilute ACC 200 or any other dosage. In the instructions for ACC 200 (powder), the method of application is described as follows:

• the bag of granules should be cut with scissors or carefully torn along the top edge;
• pour the contents into a large cup;
• pour the powder with hot water (200 ml).

To dissolve ACC 200 in the powder as quickly as possible, stir the solution with a teaspoon.

What water to dissolve in?

It is not without reason that the instructions for use emphasize how to dilute ACC 200 (powder) to obtain the most effective potency of the mixture. The water for diluting the granules must be hot.

How to use?

Pay attention to this nuance about the medication ACC 200 (powder) - how to drink it to achieve maximum effect.

1. The instructions indicate that the solution should be drunk immediately after preparation, that is, hot after eating.
2. Drinking a hot drink for colds and coughs will allow the active substances of the solution to be absorbed into the blood faster, and therefore more quickly exhibit mucolytic properties.
3. If the patient has a febrile condition (high temperature), the solution should be allowed to cool to warm or room temperature.
4. The instructions for use do not advise keeping the solution prepared but not drunk for longer than 3 hours.

Is there such information - when using the medication ACC (powder) 200, how to take other liquids: decoctions, infusions or teas? Yes, the instructions approve of the additional use of other warm liquids, emphasizing that they will help enhance the mucolytic effect of this drug.

How long can you drink?

Mucolytic drugs for cold coughs are usually taken for 5–7 days. For diseases with a long course, the dosage is determined by the doctor, and for the treatment of chronic diseases, long courses of taking ACC 200 mg (powder) are used. How long to take drugs for such a complex pathology as cystic fibrosis or chronic bronchitis depends on the factor of remission.

Important information for patients

Before using any drug, the patient should not, but simply must, read the special instructions in the annotation. It is important to know not only how to dilute ACC 200 powder according to the instructions for use, but also what undesirable effects may arise from its use. And the main thing is whether you or your child can take it at all. This question will be answered in the “Contraindications” section in the instructions for use of the powder.

This section contains a list of situations in which the use of ACC 200 granules is impossible:

In addition, ACC 200 is prohibited for use by patients with increased sensitivity to the active or additional ingredients.

Caution should be exercised when consuming ACC 200 granules when:

• bronchial asthma (if severe exacerbation - prohibited!);
• history of peptic ulcers;
• diseases of the adrenal glands;
• renal or hepatic insufficiency;
• increased sensitivity to histamine;
• hypertension.

It is also necessary to remember that taking drugs, especially long-term, can provoke undesirable effects in the form of allergic reactions, respiratory dysfunction, dyspeptic disorders and others. Severe side effects can be caused by an overdose.

What kind of reviews does the drug receive?

ACC (powder) has been present on the pharmacological market for several decades, and patients continue to write mostly positive reviews of this medication.

And yet there are several points that are named by consumers as disadvantages of this powder:

• a list of contraindications (this scares some people off);
• inability to use during pregnancy or breastfeeding;
• prohibition on use in young patients (mothers of 2-3 year olds).

Everything else, including a pleasant taste and an affordable price, was named by the majority of those who used ACC 200 according to the instructions for use as the advantages of this drug.

ACC powder 600 mg

ACC at a dosage of 600 mg of acetylcysteine ​​per sachet is designed for adult patients and is recommended for use once a day. Its taste may differ slightly from the powder discussed above, but the pharmacological properties are similar.

Prohibited for use by children and adolescents. You can read about the features of using the powder in this dosage in the separate instructions for use attached to the medication.

ACC granules 100 mg for children

For young patients over 2 years old, you can choose ACC in granules, packaged in 100 mg sachets. Before starting treatment, you should consult a doctor, clarify the nature of the cough (this can only be done by a specialist), and determine the duration of therapy. And be sure to read the instructions for use.

Useful video

For more information about the ACC line of drugs, see the following video:

Conclusion

1. The drug ACC 200 belongs to the group of mucolytic medications and is used in the treatment of coughs of various natures in patients over 6 years of age, in which difficult sputum discharge is observed.
2. Before use, you must read the instructions for use of the powder, find out how to dilute ACC 200, how to drink it, how long to treat and other important information.
3. The most correct step would be to visit a doctor, clarify the diagnosis and receive clear recommendations for treatment.

Do you have a question or experience regarding this issue? Ask a question or tell us about it in the comments.

ACC 200 INSTRUCTIONS

Prices for ACC 200

The presence of sulfhydryl groups in the structure of acetylcysteine ​​promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

ACC 200 is recommended for respiratory diseases accompanied by the formation of viscous, difficult to separate sputum: acute and chronic bronchitis, obstructive bronchitis, laryngotracheitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis.

Acute and chronic sinusitis, inflammation of the middle ear (otitis media).

Children over 6 years of age are recommended to take 1 sachet of ACC 200 mg (600 mg per day) 3 times a day. Children aged 2 to 5 years are recommended to take ½ sachet of ACC 200 mg 4 times a day (400 mg per day). For patients with cystic fibrosis and a body weight of more than 30 kg, if necessary, the dose can be increased to 800 mg of acetylcysteine ​​per day. The granules should be dissolved in water, juice or iced tea and taken after meals.

In rare cases, headaches, inflammation of the oral mucosa (stomatitis) and tinnitus are observed.

Extremely rare - diarrhea, vomiting, heartburn and nausea, drop in blood pressure, increase in heart rate (tachycardia).

In isolated cases, allergic reactions such as bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria are observed.

In addition, there are isolated reports of bleeding due to hypersensitivity reactions.

If side effects develop, you should stop taking the drug and consult a doctor.

Contraindications to the use of the drug ACC 200 are: hypersensitivity to acetylcysteine ​​or other components of the drug, pregnancy, breastfeeding, children under 2 years of age.

With caution - peptic ulcer of the stomach and duodenum in the acute stage; hemoptysis, pulmonary hemorrhage, esophageal varices, bronchial asthma, adrenal diseases, liver and/or kidney failure.

For safety reasons, due to insufficient data, the use of ACC 200 during pregnancy and lactation is only possible if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

With the simultaneous use of acetylcysteine ​​and antitussives, mucus stagnation may occur due to suppression of the cough reflex. Therefore, such combinations should be selected with caution.

The simultaneous use of acetylcysteine ​​and nitroglycerin can lead to an increase in the vasodilatory effect of the latter.

Pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Upon contact with metals and rubber, sulfides with a characteristic odor are formed.

Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after ingestion of acetylcysteine).

In case of an erroneous or intentional overdose of ACC 200, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

To date, no severe or life-threatening side effects have been observed.

At a temperature not higher than 25°C. Keep out of the reach of children.

3 g of granulate in bags made of three-layer material (aluminium-paper-polythene).

20 or 50 sachets in a cardboard box.

1 sachet of granules weighing 3 g ACC 200 for the preparation of an oral solution contains: 200 mg of acetylcysteine.

Excipients: sucrose, ascorbic acid, saccharin, orange flavor.

Instructions for patients with diabetes.

1 sachet of ACC 200 mg corresponds to 0.23 VE.

For patients with bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

When treating patients with diabetes, it is necessary to take into account that the drug contains sucrose.

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

Reviews ACC 200

All reviews about ACC 200

Analogues of ACC 200

Articles on the topic "Mucolytic"

Reviews about medicine. Catalogue of medicines, pharmacies, hospitals, physicians base.

ACC 200 powder for children: instructions for use

One of the very popular mucolytic drugs is ACC 200, so it is often prescribed for coughs with viscous sputum. But is this medicine suitable for children?

Release form

ACC 200 is produced in two forms:

• Powder packaged in portioned bags weighing 3 grams. It is presented in homogeneous white granules that smell of honey and lemon. Orange powder is also available. One pack contains 20 packets of medicine.
• Effervescent tablets. The manufacturer offers packages of 20 of these white round tablets with blackberry flavor.

Compound

The active substance in ACC 200 is acetylcysteine, of which each tablet or each serving package contains, as the name implies, 200 mg. ACC 200 powder also includes sucrose, sodium saccharinate, ascorbic acid and flavorings (lemon and honey). In addition to vitamin C and orange flavor, orange granules contain saccharin and sucrose for a sweet taste.

Additional substances in the tablets are citric acid, milk sugar, bicarbonate, saccharinate, sodium citrate and carbonate, mannitol, ascorbic acid and blackberry flavor.

Operating principle

The main effect of acetylcysteine, which is contained in ACC 200, is mucolytic. Such a substance directly affects sputum in the respiratory tract, changing its rheological properties. This is due to the ability to destroy the bonds of mucopolysaccharides in sputum, as a result of which the viscosity of the secretion decreases. In this case, the drug does not lose activity, even if there is pus in the sputum.

Acetylcysteine ​​also has antioxidant properties, because it is able to neutralize oxidative radicals and stimulate the formation of glutathione. The result of this action will be an increase in cell protection and a decrease in the intensity of inflammation.

Video presentation of the drug ACC 200:

Can it be given to children?

The instructions for use clarify that the use of acetylcysteine ​​is permitted from the age of two. In this case, a single dose for children under 6 years of age is usually 100 mg of the active substance, so you have to divide the sachet or tablet in half. The drug ACC 200 is designed for ages over 6 years.

Indications

Doctors prescribe ACC 200 if necessary to improve sputum separation and thin it. The medicine is prescribed in childhood for:

• Pneumonia.
• Bronchiolitis or bronchitis.
• Chronic lung diseases, including obstructive ones.
• Bronchiectasis.
• Otitis media.
• Sinusitis.
• Cystic fibrosis.
• Abscess in the lung.

Contraindications

The drug should not be taken in the following situations:

• If the child has intolerance to acetylcysteine ​​or other components of the medicine.
• If a peptic ulcer has worsened.
• If there is blood in the sputum.
• If the baby has glucose-galactose malabsorption.
• When pulmonary hemorrhage is detected.

Prescribing a medication requires increased attention from a doctor if the child has bronchial asthma, high blood pressure, or kidney, adrenal or liver diseases have been identified. The granules should not be given to children with fructose intolerance or sucrase deficiency.

Effervescent tablets are contraindicated in cases of lactose intolerance or lactase deficiency.

Side effects

• ACC 200 can provoke an allergy, which manifests itself in children as a skin rash, low blood pressure, itching, swelling, urticaria or tachycardia. An anaphylactic reaction is very rare.
• The respiratory system of children can react to ACC with shortness of breath, and in bronchial asthma the medicine can cause bronchospasm.
• In some children, under the influence of ACC, the digestive system may suffer, which is manifested by dyspepsia, heartburn, nausea, loose stools, stomatitis, vomiting or abdominal pain.
• Occasionally, taking ACC provokes headaches, tinnitus, fever or bleeding.

Instructions for use and dosage

ACC 200 powder should be diluted and given to the child to drink after meals. For one sachet, take half a glass of liquid, which can be represented not only by water, but also by cool tea or juice. Effervescent tablets are diluted only with water.

The prepared solution should be drunk as soon as possible after preparation. Due to the presence of ascorbic acid in the composition, the diluted medicine can be stored for up to two hours after it is diluted with liquid.

The dose of the medicine will depend on age:

• At 2-6 years of age, the child is given mg of acetylcysteine ​​per day. Since the daily dosage is divided into 2 times, the single dose will be mg. In most cases, half a sachet of ACC 200 is taken at one time. If tablets are used, then for a child under 6 years old, break the effervescent tablet into halves and mix only 1/2 with water. However, at this age it is more convenient to use the medicine ACC 100.
• At the age of 6-14 years, the daily dosage will be mg of acetylcysteine, so a single dosage is most often represented by a whole sachet or a whole effervescent tablet ACC 200, and the medicine is taken 2 times a day.
• Children over 14 years of age are given mg of acetylcysteine ​​per day, dividing this dosage into 1-3 doses. At this age, it is already acceptable to use the medicine ACC Long.

The duration of treatment with ACC 200 should be determined by the doctor, but in acute pathologies without complications, the drug is often prescribed for 5-7 days.

Overdose

If the dosage of ACC for a child is too high, the baby’s body will react to the drug with nausea, loose stools or vomiting. Symptomatic therapy can help in such a situation.

Interaction with other drugs

• It is not recommended to dissolve ACC tablets or powder in the same glass with any other medications.
• When taking activated carbon, the activity of acetylcysteine ​​will decrease.
• It is unacceptable to prescribe ACC 200 and any antitussive medications, since a suppressed cough reflex can cause mucus stagnation in the bronchi.
• When ACC and bronchodilators are prescribed, their effectiveness increases.
• Some antibiotics (cephalosporins, penicillins, tetracycline) lose their antimicrobial activity when interacting with acetylcysteine, so you should pause between such medications, taking them at least 2 hours apart.
• The simultaneous administration of ACC 200 and nitroglycerin or other vasodilating drugs causes a more pronounced vasodilating effect.

Terms of sale

To purchase ACC 200 at a pharmacy, you do not need a doctor's prescription. The average cost of a package with 20 sachets is 130 rubles.

Storage conditions and shelf life

The temperature at the storage location of ACC 200 should not exceed +25°C. ACC 200 sachets have a shelf life of 4 years from the date of release, while effervescent tablets have a shelf life of only 3 years. After removing the effervescent tablet from the tube, check the tightness of the package.

Reviews

Mostly positive reviews are left about the drug ACC 200. Mothers who gave this drug to their babies for coughs noted fairly high effectiveness and a low incidence of side effects. The product facilitates the removal of phlegm and speeds up recovery. At the same time, the taste does not cause protest among most children.

Analogues

Instead of ACC, you can use other medications with the same main component, for example, the Swiss drug Fluimucil or the domestic drug Acetylcysteine. It is also possible to replace it with other drugs with a mucolytic effect, for example, carbocisteine ​​or ambroxol.

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ACC 200

ACC release form, composition and packaging

◊ Effervescent tablets white, round, flat, scored, with the smell of blackberries.

Citric acid anhydride - 558.5 mg, sodium bicarbonate, mannitol - 60 mg, ascorbic acid - 25 mg, lactose anhydride - 70 mg, sodium citrate - 0.5 mg, saccharin - 6 mg, blackberry flavoring "B" - 20 mg.

4 things. - strips (15) - cardboard boxes.

20 pcs. - aluminum tubes (1) - cardboard boxes.

20 pcs. - plastic tubes (1) - cardboard boxes.

25 pcs. - aluminum tubes (2) - cardboard boxes.

25 pcs. - plastic tubes (2) - cardboard boxes.

25 pcs. - aluminum tubes (4) - cardboard boxes.

25 pcs. - plastic tubes (4) - cardboard boxes.

pharmachologic effect

Mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Data on the pharmacokinetics of the drug ACC ® are not provided.

Dosage of the drug ACC 200

At cystic fibrosis Children over 6 years of age are recommended to take 2 tablets. (ACC 100) or 1 tablet. (ACC 200) 3 times/day, which corresponds to 600 mg of acetylcysteine ​​per day. Children aged 2 to 6 years - 1 tablet. (ACC 100) or 1/2 tab. (ACC 200) 4 times/day, which corresponds to 400 mg of acetylcysteine ​​per day. For patients weighing more than 30 kg with cystic fibrosis, the dose can be increased to 800 mg/day if necessary.

At short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Effervescent tablets (ACC 100 and ACC 200) should be dissolved in 1/2 glass of water. Take immediately after dissolution; in exceptional cases, you can leave the prepared solution for 2 hours.

Drug interactions

With the simultaneous use of acetylcysteine ​​and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution).

When taking acetylcysteine ​​and nitroglycerin simultaneously, the vasodilatory effect of nitroglycerin may be enhanced.

Synergism between acetylcysteine ​​and bronchodilators has been noted.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

Acetylcysteine ​​is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

When acetylcysteine ​​comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

Use of ACC 200 during pregnancy

Due to insufficient data, the use of the drug during pregnancy and lactation is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child.

Use in childhood

Contraindications: children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration 200 mg); children under 14 years of age (dosage forms containing acetylcysteine ​​600 mg).

ACC side effects

From the nervous system: rarely - headache, tinnitus.

From the digestive system: rarely - stomatitis; very rarely - diarrhea, vomiting, heartburn and nausea.

From the cardiovascular system: very rarely - decreased blood pressure, tachycardia.

Allergic reactions: in isolated cases - bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria.

Others: in isolated cases - the development of bleeding as a manifestation of a hypersensitivity reaction.

Conditions and periods of storage of the drug ACC 200

The drug should be stored out of reach of children, in a dry place at a temperature not exceeding 25°C. Shelf life - 3 years.

After taking the tablet, the tube should be tightly closed.

Indications for use ACC 200

Respiratory diseases accompanied by increased formation of viscous, difficult to separate sputum (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis);

Acute and chronic sinusitis;

Special instructions when taking ACC 200

For bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

If adverse reactions develop, the patient should stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

When treating patients with diabetes, it is necessary to take into account that 1 effervescent tablet ACC 100 and ACC 200 corresponds to 0.006 XE.

Impact on the ability to drive vehicles and operate machinery

There is no data on the negative effect of the drug in recommended doses on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.

Conditions for dispensing from pharmacies

The drug ACC 200 is approved for use as an over-the-counter product.

*The description of the drug is based on the officially approved instructions for use and approved by the manufacturer for the 2012 editions

ACC description and instructions provided by the Vidal reference book of medicines

Mention of the drug "ACC 200" in user posts:

Analogues of the drug ACC 200

Reviews about the drug ACC 200:

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The composition of the drug ACC 200 includes the active ingredient acetylcysteine (200 mg), as well as additional components: sodium bicarbonate, citric anhydride, ascorbic acid, mannitol, sodium citrate, saccharin, lactose anhydride, flavoring.

Release form

ACC 200 is produced in effervescent tablets, white, round, flat, with a score line on one side. They have a blackberry aroma. Contained in packages of 4, 20, 25 pcs.

pharmachologic effect

The product has a mucolytic effect. Due to the fact that the structure of the molecule contains acetylcysteine ​​sulfhydryl groups, the disulfide bonds of acidic mucopolysaccharides of sputum are broken. As a result of this process, the viscosity of the mucus decreases. ACC 200 also demonstrates activity in patients with purulent sputum.

If acetylcysteine ​​is used for prophylactic purposes, in patients who suffer from cystic fibrosis and chronic , the severity and frequency of exacerbations decreases.

Pharmacokinetics and pharmacodynamics

After internal administration, the drug is rapidly absorbed. Metabolism in which the metabolite is formed - and other metabolites, passes through the human liver.

Bioavailability when taken internally is 10%, binding to plasma proteins is 50%. The highest concentration is observed after 1-3 hours. It is excreted in the urine, the half-life is 1 hour.

Indications for use

The use of ACC 200 is indicated in the following cases:

• for diseases of the respiratory system, if viscous sputum is formed, which is difficult to separate (acute / chronic / obstructive bronchitis, bronchiectasis, cystic fibrosis, pneumonia, , );

Contraindications

It is contraindicated to take tablets in the following cases:

• high sensitivity to acetylcysteine ​​or other drug ingredients;
• period of exacerbation ;
• pulmonary hemorrhage;
• hemoptysis;
• lactose intolerance, lactase deficiency;
• glucose-galactose malabsorption;
• child's age up to 2 years.

This medicine is used with caution in case of duodenal ulcer and a history of histamine intolerance. The medicine is also carefully prescribed to people with varicose veins of the esophagus, obstructive bronchitis, diseases of the adrenal glands, liver failure and, arterial hypertension .

Side effects

The following side effects may occur while taking the drug:

• nervous system: noise in ears, ;
• the cardiovascular system: decrease, ;
• digestion: , nausea, vomiting, ;
• allergic reactions: isolated manifestations – bronchospasm , skin rash;
• other reactions: isolated manifestations – bleeding.

Effervescent tablets ACC 200, instructions for use (Method and dosage)

The instructions for use of ACC 200 stipulate that the medicine, like the powder, is prescribed to patients over 14 years of age, 200 mg two to three times a day.

Patients from 6 to 14 years old take 1 tablet twice a day.

Children aged 2 to 5 years should take half a tablet of ACC 200 two to three times a day.

Patients with cystic fibrosis after 6 years are advised to take 1 tablet. 3 times a day, children under 6 years of age are prescribed the drug at the rate of 400 mg of acetylcysteine ​​per day. If the patient's weight exceeds 30 kg, the dose, if necessary, is increased to 800 mg per day.

If colds are being treated, the course of treatment lasts 5-7 days.

Before taking the medicine and after, you need to drink plenty of fluids to enhance the mucolytic effect of the drug. You need to take the drug after meals.

The method of diluting the tablets is the same as the method of using the powder. They need to be dissolved in half a glass of water and the solution should be drunk immediately.

Overdose

If an overdose of the drug occurs, nausea, stomach pain, , . No dangerous or severe manifestations have been observed so far.

Interaction

It should be borne in mind that when taking ACC 200 and other cough suppressants simultaneously, dangerous mucus stagnation may develop due to the fact that the cough reflex is suppressed. Therefore, such drugs must be combined carefully.

Acetylcysteine ​​may enhance vasodilatory effects if you take these drugs at the same time.

There is a synergism between acetylcysteine ​​and bronchodilators.

Acetylcysteine ​​is not compatible pharmaceutically with (penicillins, cephalosporins, ,) and proteolytic.

When taken simultaneously, acetylcysteine ​​reduces the absorption of tetracycline, cephalosporins, and penicillins. Therefore, you need to take such drugs at intervals of at least two hours.

If acetylcysteine ​​comes into contact with rubber or metals, sulfides are formed, which have a characteristic odor.

Terms of sale

ACC 200 can be purchased without a prescription.

Storage conditions

Keep away from children, away from moisture and light, store at a temperature of no more than 30 degrees. The tube should be tightly closed after removing the tablet.

Best before date

Store for 3 years.

special instructions

If ACC 200 is prescribed to patients with bronchial asthma and obstructive bronchitis, it is necessary to do this carefully and constantly monitor bronchial patency.

If any side effects develop, you should stop treatment and consult a doctor.

If necessary, dissolve the drug using glass containers.

In this article you can read the instructions for use of the drug ACC. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of ACC in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. ACC analogues in the presence of existing structural analogues. Use for the treatment of bronchitis and dry cough in adults, children, as well as during pregnancy and lactation. Various forms of release of the drug for thinning sputum.

ACC- mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Compound

Acetylcysteine ​​+ excipients.

Indications

• respiratory diseases accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);
• acute and chronic sinusitis;
• Otitis media

Release forms

Powder or granules for making syrup 100 mg.

Syrup 100 ml.

Effervescent tablets 100 mg, 200 mg, 600 mg long.

Solution for injection ACC injection - 100 mg and 300 mg in 1 ml.

Instructions for use and dosage

Powder or effervescent tablets

Adults and adolescents over 14 years of age are recommended to prescribe the drug 200 mg 2-3 times a day (ACC in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg), or 200 mg 3 (ACC in the form of granules for preparing a solution for oral administration 200 mg) or 600 mg 1 time per day (ACC in the form of granules for preparing an oral solution 600 mg).

Children aged 6 to 14 years are recommended to take 100 mg 3 times a day or 200 mg 2 times a day (ACC in the form of granules for oral solution / orange / 100 mg and 200 mg), or 200 mg 2 times a day (ACC in the form of granules for the preparation of a solution for oral administration 200 mg).

There is not enough data on the dosage of the drug in newborns.

For cystic fibrosis, children over 6 years of age are recommended to take the drug 200 mg 3 times a day (ACC in the form of granules for preparing an oral solution /orange/ 100 mg and 200 mg or ACC in the form of granules for preparing an oral solution 200 mg ).

Children aged 2 to 5 years - 100 mg 4 times a day (ACC in the form of granules for the preparation of an oral solution / orange / 100 mg and 200 mg).

For patients weighing more than 30 kg with cystic fibrosis, if necessary, the dose can be increased to 800 mg per day.

For sudden short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Rules for preparing the drug

ACC in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg: 1/2 or 1 sachet (depending on the dose) dissolved in water, juice or iced tea and taken after meals.

ACC in the form of granules for the preparation of a solution for oral administration 200 mg and ACC in the form of granules for the preparation of a solution for oral administration 600 mg: 1 sachet is dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Syrup

Adults and adolescents over 14 years of age are prescribed 10 ml of syrup 2-3 times a day (400-600 mg of acetylcysteine).

Children aged 6 to 14 years - 5 ml of syrup 3 times a day or 10 ml of syrup 2 times a day (300-400 mg of acetylcysteine).

Children aged 2 to 5 years are prescribed 5 ml of syrup 2-3 times a day (200-300 mg of acetylcysteine).

For cystic fibrosis, children over 6 years of age are recommended to take the drug 10 ml of syrup 3 times a day (600 mg of acetylcysteine); children aged 2 to 6 years - 5 ml of syrup 4 times a day (400 mg of acetylcysteine).

For short-term colds, the duration of use is 4-5 days. For chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections. For long-term illnesses, the duration of therapy is determined by the attending physician.

The drug is taken orally after meals. Additional fluid intake enhances the mucolytic effect of the drug.

ACC syrup is taken using a measuring syringe or measuring cup contained in the package. 10 ml of ACC syrup corresponds to 1/2 measuring cup or 2 filled syringes.

Using a measuring syringe

1. Open the bottle cap by pressing on it and turning it counterclockwise.

2. Remove the cap with the hole from the syringe, insert it into the neck of the bottle and press in until it stops. The stopper is designed to connect the syringe to the bottle and remains in the neck of the bottle.

3. It is necessary to insert the syringe tightly into the stopper. Carefully turn the bottle upside down, pull the syringe plunger down and draw the required amount of syrup (ml). If air bubbles are visible in the syrup, press the plunger all the way and then refill the syringe. Then return the bottle to its original position and remove the syringe.

4. The syrup from the syringe should be poured onto a spoon or directly into the child’s mouth (into the cheek area, slowly, so that the child can swallow the syrup). While taking the syrup, the child should be in an upright position.

5. After use, rinse the syringe with clean water.

Ampoules for injections

Adults are prescribed intravenously or intramuscularly at 300 mg (1 ampoule) 1-2 times a day.

Children aged 6 to 14 years are prescribed IV or IM 150 mg (1/2 ampoule) 1-2 times a day.

For children under 6 years of age, oral therapy is preferred, however, if indicated and parenteral administration is necessary, the daily dose is 10 mg/kg body weight.

For children under 1 year of age, intravenous administration of the drug is possible only for health reasons in a hospital setting.

The duration of therapy is determined individually.

In case of chronic bronchitis and cystic fibrosis, the use of ACC INJECT for a long time can be combined with oral administration of the drug to prevent infections.

The mucolytic effect of acetylcysteine ​​increases with increased fluid intake.

Rules for injections

With intramuscular injection, when performing a shallow injection and in the presence of increased sensitivity, a slight and quickly passing burning sensation may occur, therefore it is recommended to administer the drug to patients in a supine position and deep into the muscle.

For intravenous administration, the first dose must be diluted with 0.9% sodium chloride solution or 5% dextrose solution in a 1:1 ratio. The drug should, if possible, be administered by infusion.

IV injections should be administered slowly (over 5 minutes).

Side effect

• headache;
• noise in ears;
• stomatitis;
• diarrhea;
• vomit;
• heartburn;
• nausea;
• drop in blood pressure;
• tachycardia;
• development of pulmonary hemorrhage as a manifestation of a hypersensitivity reaction;
• bronchospasm (mainly in patients with a hyperreactive bronchial system with bronchial asthma);
• skin rash;
• hives.

Contraindications

• peptic ulcer of the stomach and duodenum in the acute phase;
• hemoptysis;
• pulmonary hemorrhage;
• pregnancy;
• lactation period (breastfeeding);
• children under 2 years of age (the drug is in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg, syrup and ACC 200);
• children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration, 200 mg);
• children under 14 years of age (the drug in the form of granules for the preparation of a solution for oral administration 600 mg and ACC Long);
• hypersensitivity to acetylcysteine ​​and other components of the drug.

Use during pregnancy and breastfeeding

Due to insufficient data, the use of the drug during pregnancy is contraindicated.

For syrup: use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Use in children

Contraindicated for children under 2 years of age (the drug in the form of granules for the preparation of an oral solution /orange/ 100 mg and 200 mg, syrup and ACC 200), up to 6 years of age (the drug in the form of granules for the preparation of an oral solution 200 mg) , up to 14 years (the drug in the form of granules for the preparation of a solution for oral administration 600 mg and ACC Long).

special instructions

For bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

Severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes in the skin and mucous membranes occur, the patient should immediately stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime (the preferred time of administration is before 18.00).

If side effects develop, you should stop taking the drug.

ACC (in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Impact on the ability to drive vehicles and operate machinery

There is no information on the effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug interactions

With the simultaneous use of acetylcysteine ​​and antitussives, dangerous mucus stagnation may occur due to suppression of the cough reflex (use the combination with caution).

When taking ACC with vasodilators and nitroglycerin simultaneously, the vasodilator effect may be enhanced.

There is a synergism between acetylcysteine ​​and bronchodilators.

ACC is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

When acetylcysteine ​​comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

Analogues of the drug ACC

Structural analogues of the active substance:

• N-AC-ratiopharm;
• N-acetylcysteine;
• Acestine;
• Acetylcysteine;
• Acetylcysteine ​​SEDICO;
• Acetylcysteine ​​solution for inhalation 20%;
• Acetylcysteine ​​solution for injection 10%;
• Mukobene;
• Mucomist;
• Mukonex;
• N-AC-ratiopharm;
• Fluimucil;
• Exomyuk 200.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.