Basic physical and chemical properties. Which is better Furadonin or Furagin

Are there analogues of furadonin? The genitourinary system is very often subject to infection. Cystitis, urethritis, pyelonephritis, unpleasant diseases, requiring urgent treatment. The question arises, with what? Most often treated with furadonin.

It is not an antibiotic and does not affect the intestinal flora. It has several analogues that also treat inflammation of the urinary system. This is what our article is about.

Furagin

When treating patients suffering from inflammatory infections urinary system, use these drugs. They have an antimicrobial effect.

Medicines are not antibiotics and do not have a negative effect on immune system.
Most bacteria caused by sensitive ones (staphylococci, E. coli, genital tract infections) react equally to them.

The drugs act on the microorganism itself, destroying its shell, reducing the amount of toxins. Therapeutic effect occurs in the first days of taking the pills.

They activate protective forces body, due to this, recovery occurs faster.
Prescribed for the following pathologies:

Infections of the excretory tract.
Cystitis, pyelonephritis.
Medical manipulations.

Obvious signs of the disease disappear the next day. They can be taken for chronic forms and are prescribed for prevention.

What is the difference between the drugs? In their composition. Furadonin consists of the active substance nitrofurantoin, furagin from furazidin.

The doctor must take into account that the patient may have an allergic reaction to some medicine. They are interchangeable for cystitis and urethritis.

At long-term use no addiction. Both are contraindicated for children under 3 years of age, pregnant and lactating women.

Side effects

Cause the same effects:

Nausea.
Nervous disorders.
Dysbacteriosis.

You should not take them uncontrollably. Treatment should be carried out under the supervision of a physician.

Furamag

Both have a wide spectrum of action. The main use is for bladder inflammation. They also drink for other kidney diseases and urinary tract.

The main active ingredient belongs to one group of furazidins. Furamag has additional magnesium and potassium, which contribute to rapid absorption drug.

The drugs have the same activity against pathogens. Habituation develops slowly, which makes it possible to take long time, no harm to intestinal flora. They are not antibiotics, but have a strong antimicrobial effect.

While taking tablets or capsules, you must drink a large amount of liquid so that toxins are removed from the body and do not poison it.

These drugs are used to prevent diseases of the urinary system, as auxiliary treatment for severe infectious lesions.

This group of medications is used for surgical intervention on the bladder, with various medical manipulations(cystoscopy, catheter installation) to avoid the development of inflammation.

Frequency, course of administration, dosage are approximately equal. The difference is in the manufacturer and price. Furamag - Latvia, much more expensive.

Side effects

They act the same. The drugs cause nausea, stomach discomfort, drowsiness, and tinnitus. In some cases, there is itching or hives.

The question of which drug is better cannot be answered unambiguously. They have the same indications for use, but affect the body differently.

The doctor must write a prescription based on individual characteristics. The medicine must be taken strictly as prescribed by the doctor. Do not exceed the dosage, follow all recommendations.

Monural

If we compare these drugs, we must say that they are of different classes. Furadonin – antibacterial agent Monural is an antibiotic.

It is more commonly prescribed for acute form, is considered very strong. It contains phosphonic acid, which is an antiseptic.

According to patients, cystitis can be treated in 2-3 days with monural. It is available in the form of a suspension and powder for dilution.

Take twice a day, morning and evening. The peculiarity is that before taking it you need to empty the bladder so that the action is more effective.

Monural is well tolerated, does not affect the intestinal microflora, and has no contraindications. It can be used by pregnant and lactating women.

5-NOK

5-NOK or furadonin, which is better? 5-NOK – antibacterial, antifungal drug, with active substance nitroxoline has a wider spectrum.

In most cases, it is better to take it than furadonin. It is often used when chronic pyelonephritis.

Treatment can be carried out in courses of two weeks. The duration of treatment is several months. After entering the stomach, it is absorbed by 90%.

It is used for inflammation of the urinary system, acute and chronic pyelonephritis, prostatitis, adenoma. If we compare drugs for cystitis, then furadonin is more effective. It relieves the acute course of the disease faster.

The question is often asked whether it is possible to use nitroxoline (5 NOC) and furadonin at the same time. If we're talking about about acute cystitis, then it makes no sense, they have the same effect.

Nitroxoline has a minimum of side effects. Nausea and stomach problems occur very rarely.

Furazolidone

Are furazolidone and furadonin the same thing? There are many tablets for the treatment of cystitis, which ones should you choose? To find out you need to compare them.

Furadonin is antimicrobial and is always prescribed for acute cystitis. Getting into the blood and lymph, it kills microbes that cause inflammation. It has many contraindications and adverse reactions.

It is prescribed during acute period cystitis. It belongs to antibiotics, since the treatment is carried out for three days, negative influence no for microflora.

Many substitutes differ from furadonin in their composition, but the effect they produce on infections genitourinary system are identical.

For proper treatment diseases, you need to make a correct diagnosis based on certain tests. Only a specialist will do this.

Self-medication antimicrobials and antibiotics can be counterproductive. The disease will progress to chronic form, it will be very difficult to cure her. Read new articles on our website.

active substance: nitrofurantoin;

1 tablet contains nitrofurantoin 50 mg or 100 mg

Excipients: potato starch, colloidal silicon dioxide, calcium stearate.

Dosage form

Pills.

Pharmacological group

Antibacterial agents. ATC code J01X E01.

Indications

Bacterial infections of the urinary tract (pyelitis, pyelonephritis, cystitis, urethritis), including for the treatment of relapses, as well as to prevent infection during urological operations, catheterization, cystoscopy.

Contraindications

Hypersensitivity to nitrofurantoin or to excipients drug
anuria
oliguria;
acute porphyria;
renal failure (creatinine clearance less than 60 ml/min);
cirrhosis of the liver
chronic hepatitis
chronic heart failure II and II degrees;
patients on hemodialysis or peritoneal dialysis;
deficiency of glucose-6-phosphate dehydrogenase (threat of hemolytic anemia);
neuritis and polyneuropathy.

Directions for use and doses

The drug is taken orally, immediately after a meal, with a glass of water big amount water.

Acute infections: adults and children over 12 years old - 100 mg 2 times a day for 7 days.

Severe chronic recurrent infections: adults - 100 mg 4 times a day for 7 days.

For adults highest single dose- 300 mg, daily - 600 mg.

Surgical prophylaxis: adults - 100 mg 2 times a day on the day of the procedure and 3 days after the procedure.

If the next dose has not been taken, the course of treatment should be continued at the previously prescribed doses.

Adverse reactions

Violations gastrointestinal tract: often - nausea, vomiting, lack of appetite, the frequency and severity of which is dose-dependent. Abdominal pain, diarrhea, and pancreatitis are less common. Side effects from the gastrointestinal tract are less common if the drug is taken with food with plenty of liquid.

From the outside nervous system: rarely - headache, drowsiness, dizziness, depression, euphoria, nystagmus, confusion, psychotic reactions, asthenia, increased intracranial pressure. IN rare cases serious and even irreversible peripheral polyneuropathies have been noted (numbness and burning sensation in the legs, muscle weakness), which is associated with renal failure And long-term use large doses drug. If the symptoms mentioned above occur, the drug should be stopped.

Violation respiratory system: rarely - acute pulmonary reactions hypersensitivity are characterized sudden appearance fever, eosinophilia, cough, chest pain, shortness of breath. Pulmonary infiltrate or consolidation and pleural effusion may occur within hours or days after initiation of therapy; they usually resolve after stopping the drug. Subacute or acute pulmonary symptoms, including pulmonary fibrosis may develop silently in patients with long-term therapy; fibrosis may be irreversible, especially if therapy was continued after the onset of symptoms. In patients bronchial asthma Asthmatic attacks may occur. When the first signs of a respiratory system disorder appear, the drug should be stopped.

Impaired liver and/or biliary tract function: rarely - chronic active hepatitis, cholestatic jaundice (there are dose-dependent jaundice. Metabolized and disappear after discontinuation of the drug), pseudomembranous colitis, cholestatic syndrome.

Skin damage and subcutaneous tissue : often - hypersensitivity reactions - rash, maculopapular rash, urticaria, itching in some cases angioedema, anaphylaxis, inflammation salivary glands, eczema, exfoliative dermatitis, erythema multiforme (Stevens-Johnson syndrome) , lupus-like syndrome.

Violation of hematopoietic and lymphatic systems: rarely - megaloblastic anemia, leukopenia, granulocytopenia or agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency.

From the outside musculoskeletal system: gout, myalgia.

Other: rarely - blurred vision, joint pain, reversible hair loss, fungal superinfection, possible resistance to microorganisms such as Pseudomonas. Furadonin colors urine dark yellow or brown.

Overdose

Symptoms: vomit.

Treatment: drug withdrawal, use large quantity liquids, the use of enterosorbents, antihistamines, vitamins of group B. Application features. There is no specific antidote.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and breastfeeding.

Children

The drug can be used in children over the age of 12 years.

Application features

Furadonin is prescribed with caution to elderly patients who have an increased risk toxic effect namely: acute pulmonary reactions. Patients who receive long-term therapy, it is advisable to conduct a pulmonary function test and stop taking the drug at the first signs of lung damage.

Particular care should be taken when treating patients with already existing pathology kidneys, liver, neurological and allergic diseases, as well as with conditions that contribute to the development of peripheral neuropathy (anemia, diabetes, electrolyte imbalance, exhaustion, vitamin B deficiency). Furadonin should be discontinued in case of manifestations of peripheral neuropathy.

You should also be careful with folic acid deficiency.

At long-term treatment furadonin, it is necessary to periodically monitor the composition peripheral blood, functional state liver and kidneys.

Furadonin may give false-positive reactions to urine sugar (when using the copper reduction method).

Furadonin may cause diarrhea caused by Clostridium difficile. Furadonin treatment changes normal microflora colon and contributes excessive growth Clostridium difficile. If diarrhea is suspected or confirmed due to Clostridium difficile, furadonin treatment should be discontinued and appropriate treatment should be carried out. Rarely, treatment with furadonin can lead to the emergence of resistant microorganisms. In this case, you should stop taking the drug.

During treatment you should refrain from drinking alcoholic beverages.

The ability to influence the reaction rate when driving vehicles or other mechanisms

The drug does not affect the reaction rate when driving vehicles or other mechanisms, but for persons who experience dizziness, headache or other side effects from the central nervous system, caution should be exercised.

Interaction with other drugs and other types of interactions

The antibacterial activity of furadonin decreases in alkaline urine, so it should not be combined with drugs that increase urine pH. Magnesium trisilicate reduces the absorption of furadonin, but it is unknown whether this also applies to other antacids.

Furadonin and drugs of the quinolone group should not be used simultaneously.

The excretion of furadonin is reduced by probenecid and sulfinpyrazone, so they should not be taken at the same time.

Carbonic anhydrase reduces antibacterial activity drug, nitrofurantoin reduces estrogen reabsorption, effectiveness contraceptives, which patients who simultaneously use contraceptives should be warned about.

Orally inactivates the protozoan vaccine.

At simultaneous use nalidixic acid and medicines, which block tubular secretion, decreases antibacterial effect(by reducing the concentration of nitrofurantoin in the urine) and increases the toxicity (increases the concentration in the blood) of nitrofurantoin.

Use simultaneously with chloramphenicol, ristomycin and sulfonamides increases the inhibition of hematopoiesis.

The antibacterial effect of furadonin is significantly enhanced when used simultaneously with antibiotics (penicillins and cephalosporins), and combines well with tetracycline and erythromycin.

No interaction was observed with the simultaneous use of furadonin with alcohol. However, you should avoid drinking alcohol to prevent unexpected reactions.

Furadonin increases the nephrotoxicity of other nephrotoxic drugs.

Pharmacological properties

Pharmacodynamics. Nitrofurantoin - synthetic antimicrobial agent, a derivative of nitrofuran. It has a bacteriostatic effect, but can also act bactericidal depending on the concentration and sensitivity of microorganisms. Disturbs the synthesis of DNA, RNA and protein in bacterial cells. Resistance of microorganisms to nitrofurantoin rarely develops. Nitrofurantoin is active against some gram-positive and gram-negative bacteria(staphylococci, streptococci, coli, pathogens typhoid fever, dysentery, various strains of Proteus).

Pharmacokinetics. Nitrofurantoin is well absorbed into digestive tract. The maximum concentration in the blood serum after oral administration is achieved within 30 minutes. Ingestion of food may also increase the bioavailability of nitrofurantoin and the duration of therapeutic concentrations. Nitrofurantoin is 20-60% bound to plasma proteins. Despite the fact that the drug is metabolized in the liver and muscle tissue, from 30% to 50% of the dose is excreted unchanged in the urine. Therefore, it has a bacteriostatic and bactericidal effect against urinary tract infections. The drug is completely excreted from the body by the kidneys. The half-life is approximately 20 minutes. Furadonin is active in acidic urine. If urine pH exceeds 8, most of the bactericidal activity is lost. Furadonin penetrates the placenta and blood-brain barrier into breast milk.

Basic physical and chemical properties

tablets of yellow or greenish-yellow color, flat-cylindrical, with a chamfer.

Best before date

Do not use after expiration date.

Storage conditions

Store in original packaging at temperatures up to + 30 o C.

Keep out of the reach of children.

Package

10 tablets in contour-free packaging;

10 tablets in a blister,

2 blisters per cardboard pack.

Vacation category

On prescription.

Manufacturer

Open Joint-Stock Company"Borisov Medical Preparations Plant".

Location

Republic of Belarus, 222120, Minsk region, G.. Borisov, st. Chapaeva, 64/27

At inflammatory processes organs of the urinary system caused by bacterial microflora antimicrobial agents are prescribed.

Among them, Furadonin is considered to be one of the most effective.

In its absence in pharmacy chain you can pick up suitable analogue, which has a similar composition and effect.

basic information

The drug belongs to the group of antimicrobial nitrofuran agents. It is not an antibiotic, but is capable of having a bacteriostatic and bactericidal effect on many species pathogenic microorganisms(staphylococci, streptococci, Klebsiella, Escherichia coli, Salmonella, Shigella, etc.).

The mechanism is based on suppression of the synthesis of protein compounds in the walls of bacteria. Thus, permeability cell membrane worsens, microorganisms cannot reproduce and die.

Main active ingredient is a synthetic substance. Furadonin is classified as a powerful antiseptic, not antibacterial drug. Characteristic feature is low level pathogen resistance to nitrofurantoin.

Available in the form of tablets of 30, 50 and 100 mg, as well as in the form of a suspension for oral intake. Once in the body, it is quickly absorbed by the walls of the gastrointestinal tract and tends to penetrate the placental barrier and into breast milk. It is excreted mainly by the kidneys unchanged. During treatment, urine turns dark red.

In rare cases, it may occur side symptoms in the form of allergies, abdominal pain, diarrhea, difficulty breathing, severe drowsiness, disorders rheological properties blood.

Often, women develop candidiasis or dysbacteriosis while taking the drug, so it is advisable to take it in parallel antifungal drugs and probiotics.

Furadonin is enough inexpensive drug, available in pharmacies without a prescription. average cost is in the range of 60-150 rubles per package (depending on the concentration of the active component).

Indications and contraindications

Furadonin is widely used in the treatment of acute or chronic diseases in the urinary system

It is prescribed for preventive purposes during surgery (on the bladder, kidneys, etc.), installation, Prescribed in complex therapy bacterial-fungal or bacterial-viral infection. Helps with repeated relapses of diseases.

Among the main contraindications it is necessary to highlight:

intolerance to components;
renal pathologies;
liver dysfunction (hepatitis, cirrhosis, etc.);
problems with the cardiovascular system;
congenital or acquired deficiency of B vitamins and the enzyme glucose-6-phosphate dehydrogenase;
pregnancy and breastfeeding;
patient age up to 1 month;
inflammatory process in the prostate gland;
purulent form.

It is important to note that for children under 3 years of age, Furadonin is prescribed in the form of a suspension. For everyone else age groups- tablets with different concentrations active substance.

Similar means

Today, pharmacists produce a large number of domestic and foreign analogues. Their selection is carried out exclusively by the attending physician; otherwise, high risk complications.

Domestic substitutes

There are no direct analogues of Furadonin, but several drugs from the nitrofuran group can be identified that have a similar effect:

Foreign synonyms

There are also no direct analogues of Furadonin among foreign drugs, but a large number of drugs are produced that have similar action. Below is a list of the most popular:

. Belongs to the group of nitrofurans and is used to treat acute and chronic diseases of the urinary system. It has a bacteriostatic effect, slowing down the process of hydrogen ion transfer by bacterial cells. Thus, it is violated respiratory function microorganisms, which leads to their death. Not prescribed for pregnant and lactating women, children under 7 days after birth, patients with impaired liver and kidney function. Side effects include headache and dizziness, bowel dysfunction, allergic reactions. Sold in pharmacies for 170-250 rubles per pack, produced in Latvia.
The drug is produced in Latvia and also belongs to the group of nitrofuran drugs. Available in the form of enteric-coated capsules of 25 and 50 mg of active substance. It has a high bactericidal concentration and is considered one of the most effective drugs for treating infectious diseases urinary system. Significantly reduces intoxication of the body and activates immune functions. It has the same contraindications as Furadonin. Adverse symptoms are rare. The average cost is 400-600 rubles per package.
Furasol. Another Latvian-made drug, available in the form of tablets and powder for the preparation of a suspension. It has a powerful bactericidal effect and is prescribed to patients with genitourinary diseases. In the form of a solution, it is used for bacterial conjunctivitis. Not prescribed for pregnant and lactating women, children under 4 years of age, and patients with allergies to nitrofurans. To reduce the risk of developing side symptoms, it must be taken together with vitamin complexes(group B) and antihistamines. In acute forms of cystitis, douching with Furasol solution is prescribed. Price - 400-550 rubles.

Which is better Furadonin or Furagin

Both drugs belong to the same pharmacological group and have similar indications for use. Some doctors claim that Furagin is more effective, it also has a milder effect and is less likely to cause side symptoms.

The main active component of Furagin is the synthetic substance furazidin. It has a powerful antibacterial effect and is available in the form of capsules, tablets and powder for preparing a suspension.

The difference from Furadonin is the ability to use this drug to prevent relapses, since microorganisms cannot resist it.

Furagin has a number of advantages, among which it is worth highlighting:

lack of systemic effect on the body;
activation of the immune system by increasing the function of protective protein compounds and the absorption function of leukocytes.

It should be noted that an overdose of this drug is much more difficult to tolerate. Furadonin relieves symptoms more quickly in acute cystitis. Your doctor will tell you which drug is best to choose. First of all, it depends on the nature and type of the disease.

Can I take it simultaneously with Nitroxoline?

Both of these drugs belong to the group of nitrofurans. It is prohibited joint reception, as this leads to an overdose and may cause serious violations in the functioning of the nervous system.

Antimicrobial agent wide range actions, nitrofuran derivative. It has a bacteriostatic and bactericidal effect against urinary tract infections. Nitrofurantoin is active against Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.

Effective mainly for urinary tract infections.

Pharmacokinetics of Furadonin

Well absorbed from the gastrointestinal tract. Bioavailability is 50% (food increases bioavailability). The rate of absorption depends on the size of the crystals (the microcrystalline form is characterized by rapid solubility and absorption rate, short time reaching Cmax in urine). Communication with plasma proteins - 60%. Metabolized in the liver and muscle tissue. T1/2 - 20-25 min. Penetrates the blood-brain barrier, the placental barrier, and is excreted from breast milk. It is excreted completely by the kidneys (30-50% unchanged).

Indications for use

Bacterial infections of the urinary tract (pyelitis, pyelonephritis, cystitis, urethritis), prevention of infections during urological operations or studies (including cystoscopy, catheterization).

Contraindications

Hypersensitivity, chronic renal failure, chronic heart failure II-III degrees, severe liver pathology (including liver cirrhosis, chronic hepatitis), glucose-6-phosphate dehydrogenase deficiency, acute porphyria, early infancy(up to 1 month).

Side effects

From the nervous system and sensory organs: peripheral neuropathy, asthenia, dizziness, headache, drowsiness, nystagmus.

From the outside respiratory system: interstitial changes in the lungs, broncho-obstructive syndrome, fever, cough, chest pain.

From the gastrointestinal tract: hepatitis, cholestatic syndrome, nausea, vomiting, abdominal pain, diarrhea, pancreatitis, pseudomembranous colitis

Allergic reactions: lupus-like syndrome, arthralgia, myalgia, anaphylaxis, chills, eosinophilia, rash.

Furadonin- Methods of administration and doses

Inside, drinking plenty of water, adults - 0.1-0.15 g, 3-4 times / day; children - at the rate of 5-8 mg / kg / day, the daily dose is divided into 4 doses. Higher doses for adults: single - 0.3 g, daily - 0.6 g.

At acute infections urinary tract duration of treatment - 7-10 days.

Preventive, anti-relapse treatment continues, depending on the nature of the disease, from 3 to 12 months. Daily dose in this case it is 1-2 mg/kg.

Overdose

Symptoms: vomit.

Treatment: taking large amounts of fluid leads to increased excretion of the drug in the urine. Dialysis is effective.

Dosage Forms

10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - cellular contour packings (4) - packs of cardboard.
20 pcs. - contour cellular packaging (1) - cardboard packs.
25 pcs. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.

Interaction of Furadonin with other drugs

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of nitrofurantoin.

Nitrofurantoin is incompatible with fluoroquinolones.

When used simultaneously, drugs that block tubular secretion reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (increasing the concentration in the blood).

Contraindications

Hypersensitivity to nitrofurantoin or to the excipients of the drug
anuria
oliguria;
acute porphyria;
renal failure (creatinine clearance less than 60 ml/min);
cirrhosis of the liver
chronic hepatitis
chronic heart failure II and II degrees;
patients on hemodialysis or peritoneal dialysis;
deficiency of glucose-6-phosphate dehydrogenase (threat of hemolytic anemia);
neuritis and polyneuropathy.

Directions for use and doses

The drug is taken orally, immediately after a meal, drinking plenty of water.

Acute infections: adults and children over 12 years old - 100 mg 2 times a day for 7 days.

Severe chronic recurrent infections: adults - 100 mg 4 times a day for 7 days.

For adults, the highest single dose is 300 mg, the daily dose is 600 mg.

Surgical prophylaxis: adults - 100 mg 2 times a day on the day of the procedure and 3 days after the procedure.

If the next dose has not been taken, the course of treatment should be continued at the previously prescribed doses.

Adverse reactions

Gastrointestinal disorders: often - nausea, vomiting, lack of appetite, the frequency and severity of which is dose-dependent. Abdominal pain, diarrhea, and pancreatitis are less common. Side effects from the gastrointestinal tract are less common if the drug is taken with food and with plenty of liquid.

From the nervous system: rarely - headache, drowsiness, dizziness, depression, euphoria, nystagmus, confusion, psychotic reactions, asthenia, increased intracranial pressure. In rare cases, serious and even irreversible peripheral polyneuropathies have been observed (numbness and burning sensation in the legs, muscle weakness), which is associated with renal failure and long-term use of large doses of the drug. If the symptoms mentioned above occur, the drug should be stopped.

Respiratory system disorders: rarely - acute pulmonary hypersensitivity reactions are characterized by the sudden onset of fever, eosinophilia, cough, chest pain, shortness of breath. Pulmonary infiltration or consolidation and pleural effusion may occur within hours or days of starting therapy and usually resolve after discontinuation of the drug. Subacute or acute pulmonary symptoms, including pulmonary fibrosis, may develop insidiously in patients on long-term therapy; fibrosis may be irreversible, especially if therapy is continued after the onset of symptoms. Patients with bronchial asthma may experience asthmatic attacks. When the first signs of a respiratory system disorder appear, the drug should be stopped.

Impaired function of the liver and/or biliary tract: rarely - chronic active hepatitis, cholestatic jaundice (there is a dose-dependent jaundice. Metabolized and disappear after discontinuation of the drug), pseudomembranous colitis, cholestatic syndrome.

Damage to the skin and subcutaneous tissue: often - hypersensitivity reactions - rash, maculopapular rash, urticaria, itching in some cases, angioedema, anaphylaxis, inflammation of the salivary glands, eczema, exfoliative dermatitis, erythema multiforme (Stevens-Johnson syndrome), lupus-like syndrome.

Impaired functions of the hematopoietic and lymphatic systems: rarely - megaloblastic anemia, leukopenia, granulocytopenia or agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency.

From the musculoskeletal system: gout, myalgia.

Others: rarely - visual impairment, joint pain, reversible hair loss, fungal superinfection, resistance to microorganisms such as Pseudomonas is possible. Furadonin colors urine dark yellow or brown.

Overdose

Symptoms: vomiting.

Treatment: withdrawal of the drug, the use of large amounts of liquid, the use of enterosorbents, antihistamines, vitamins of group B. SPECIAL. There is no specific antidote.

Use during pregnancy or breastfeeding

The drug is contraindicated during pregnancy or breastfeeding.

Children

The drug can be used in children over the age of 12 years.

Application features

Furadonin is prescribed with caution to elderly patients who have an increased risk of toxic effects, namely: acute pulmonary reactions. For patients receiving long-term therapy, it is advisable to conduct a pulmonary function examination and stop taking the drug at the first manifestations of lung damage.

Particular care should be taken in the treatment of patients with pre-existing pathology of the kidneys, liver, neurological and allergic diseases, as well as with conditions that contribute to the development of peripheral neuropathy (anemia, diabetes mellitus, electrolyte imbalance, malnutrition, vitamin B deficiency). Furadonin should be discontinued in case of manifestations of peripheral neuropathy.

You should also be careful with folic acid deficiency.

With long-term treatment of furadonin, it is necessary to periodically monitor the composition of peripheral blood, the functional state of the liver and kidneys.

Furadonin may give false-positive reactions to urine sugar (when using the copper reduction method).

Furadonin may cause diarrhea caused by Clostridium difficile. Treatment with furadonin alters the normal microflora of the colon and promotes overgrowth of Clostridium difficile. If diarrhea caused by Clostridium difficile is suspected or confirmed, furadonin treatment should be discontinued and appropriate treatment instituted. Rarely, treatment with furadonin can lead to the emergence of resistant microorganisms. In this case, you should stop taking the drug.

During treatment you should refrain from drinking alcoholic beverages.

The ability to influence the reaction rate when driving vehicles or other mechanisms

The drug does not affect the reaction rate when driving vehicles or working with other mechanisms, but people who experience dizziness, headache or other side effects from the central nervous system during treatment should be careful.

Interaction with other drugs and other types of interactions

Furadonin and drugs of the quinolone group should not be used simultaneously.

The excretion of furadonin is reduced by probenecid and sulfinpyrazone, so they should not be taken at the same time.

Carbonic anhydrase reduces the antibacterial activity of the drug, nitrofurantoin reduces estrogen reabsorption, the effectiveness of contraceptive drugs, which should be warned by patients who simultaneously use contraceptives.

Orally inactivates the protozoan vaccine.

With the simultaneous use of nalidixic acid and drugs that block tubular secretion, the antibacterial effect decreases (by reducing the concentration of nitrofurantoin in the urine) and the toxicity (increases the concentration in the blood) of nitrofurantoin increases.

Use simultaneously with chloramphenicol, ristomycin and sulfonamides increases the inhibition of hematopoiesis.

The antibacterial effect of furadonin is significantly enhanced when used simultaneously with antibiotics (penicillins and cephalosporins), and combines well with tetracycline and erythromycin.

No interaction was observed with the simultaneous use of furadonin with alcohol. However, you should avoid drinking alcohol to prevent unexpected reactions.

Furadonin increases the nephrotoxicity of other nephrotoxic drugs.

Pharmacological properties

Pharmacological. Nitrofurantoin is a synthetic antimicrobial agent, a derivative of nitrofuran. It has a bacteriostatic effect, but can also act bactericidal depending on the concentration and sensitivity of microorganisms. Disturbs the synthesis of DNA, RNA and protein in bacterial cells. Resistance of microorganisms to nitrofurantoin rarely develops. Nitrofurantoin is active against some gram-positive and gram-negative bacteria (staphylococci, streptococci, Escherichia coli, causative agents of typhoid fever, dysentery, various strains of Proteus).

Pharmacokinetics. Nitrofurantoin is well absorbed from the digestive tract. The maximum concentration in the blood serum after oral administration is achieved within 30 minutes. Ingestion of food may also increase the bioavailability of nitrofurantoin and the duration of therapeutic concentrations. Nitrofurantoin is 20-60% bound to plasma proteins. Despite the fact that the drug is metabolized in the liver and muscle tissues, from 30% to 50% of the dose is excreted in the urine unchanged. Therefore, it has bacteriostatic and bactericidal action for urinary tract infections. The drug is completely excreted from the body by the kidneys. The half-life is approximately 20 minutes. Furadonin is active in acidic urine. If urine pH exceeds 8, most of the bactericidal activity is lost. Furadonin penetrates the placenta and blood-brain barrier into breast milk.

Basic physical and chemical properties

Tablets are yellow or greenish-yellow, flat-cylindrical, with a bevel.

Best before date

Do not use after expiration date.

Storage conditions

Store in original packaging at temperatures up to + 30 o C.

Keep out of the reach of children.

Package

10 tablets in contour-free packaging;

10 tablets in a blister,

2 blisters per cardboard pack.