Ersefuril suspension instructions for use for children. Instructions for use of ersefuril in acute bacterial diarrhea
Trade name drug: Ercefuril ® .
International generic name: nifuroxazide.
Dosage form: capsules.
Compound
1 capsule contains:
active substance: nifuroxazide - 200.0 mg;
Excipients: corn starch, sucrose, magnesium stearate.
Capsule composition
body: gelatin, titanium dioxide (E171), iron dye yellow oxide (E172);
cap: gelatin, titanium dioxide (E171), iron dye yellow oxide (E172).
Description: solid gelatin capsules No. 1, consisting of a yellow body and a yellow cap. The contents of the capsules are yellow powder.
Pharmacotherapeutic group:antimicrobial agent, nitrofuran.
ATC Code: A07AX03.
Pharmacological properties
Pharmacodynamics
Nifuroxazide is an antimicrobial agent, a derivative of nitrofuran. Blocks the activity of dehydrogenases and inhibits the respiratory chains, the tricarboxylic acid cycle and a number of others biochemical processes in a microbial cell. Destroys the membrane of microbial cells, reduces the production of toxins by microorganisms. Highly active towards Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp., Clostridium perfringens, Vibrio cholerae, pathogenic Vibrations and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.
Doesn't upset the balance intestinal microflora. With acute bacterial diarrhea restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.
Pharmacokinetics
After oral administration nifuroxazide is practically not absorbed from digestive tract, and has its antibacterial effect exclusively in the intestinal lumen. Nifuroxazide is excreted by the intestines: 20% unchanged, and the rest of the amount of nifuroxazide is chemically modified.
Indications for use
Acute bacterial diarrhea without worsening general condition, fever, intoxication.Contraindications
- Hypersensitivity to nifuroxazide, nitrofuran derivatives or other components of the drug.
- Children's age up to 3 years.
- Pregnancy.
- Fructose intolerance, glucose-galactose malabsorption syndrome, or sucrase and isomaltase deficiency (due to the presence of sucrose in the preparation
Use during pregnancy and during breastfeeding
Pregnancy
Not found in animal studies teratogenic effect. However, as a precautionary measure, taking nifuroxazide during pregnancy is not recommended (insufficient clinical experience use during pregnancy).
breastfeeding period
During the lactation period, it is possible to continue breastfeeding in the case of a short course of treatment with the drug. It is necessary to consult a doctor.
Dosage and administration
Children from 3 to 6 years old: 200 mg (1 capsule) 3 times a day (interval between doses 8 hours).Children aged 6 to 18: 2 00 mg (1 capsule) 3-4 times a day (interval between doses 6-8 hours).
Adults: 200 mg (1 capsule) 4 times a day (interval between doses 6 hours).
Duration of treatment: 5-7 days, but not more than 7 days.
If there is no improvement within the first 3 days of taking it, you should consult a doctor. Use the drug only according to the method of application and in the doses indicated in the instructions. If necessary, please consult your doctor before taking the medicine.
Side effect
Allergic reactions (skin rash, urticaria, angioedema, anaphylactic shock). If any of the instructions side effects get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.Overdose
Overdose symptoms are not known. Treatment is symptomatic.
Interaction with other medicinal products Not recommended simultaneous application with drugs, causing development disulfiram-like reactions, drugs that depress the function of the central nervous system. If you are taking other medicines (including over-the-counter medicines), consult your doctor before using Ercefuril ®.
special instructions
In the treatment of diarrhea, rehydration therapy should be carried out simultaneously with nifuroxazide therapy. In case of bacterial diarrhea with symptoms systemic lesion(deterioration of the general condition, fever, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs. If symptoms of hypersensitivity appear (shortness of breath, skin rash, pruritus) should stop taking the drug. Drinking alcohol during therapy with nifuroxazide is prohibited.
Advice for patients with diabetes
One single dose(1 capsule) of the drug Ersefuril ® contains 72.0 mg of sucrose, which corresponds to 0.00072 Bread Unit(HE). Maximum daily dose(4 capsules) contains 288 mg of sucrose, which corresponds to 0.0288 XE.
Impact on ability to drive vehicles, mechanisms
The drug Ercefuril ® does not affect the ability to drive vehicles and mechanisms.
Release form
Capsules 200 mg.
14 capsules in a PVC / aluminum foil blister.
1 or 2 blisters with instructions for use in a cardboard box.
Best before date
5 years.
Do not use the drug after the expiration date indicated on the package.
Storage conditions
Store at a temperature not exceeding 30 °C. Keep out of the reach of children.
Holiday conditions
Without recipe.
Registration certificate holder
SANOFI-AVENTIS FRANCE, France. SANOFI-AVENTIS FRANCE, France.Manufacturer
Delpharm Dijon, France
Delpharm Dijon, France
6, Boulevard de G Europe, 21800, Quetigny, France.
Claims of consumers should be sent to the address in Russia:
125009, Moscow, st. Tverskaya, 22.
The drug Ersefuril indications for use, which allow it to be used to eliminate problems in the gastrointestinal tract, is special drug to eliminate diarrhea. It belongs to the group of intestinal antiseptics.
Ercefuril is produced in hard gelatin capsules, which have a yellow body and cap. Inside is a powder that color scheme similar to a capsule. Main operating medicinal substance in Ercefuril - nifuroxazide, and auxiliary components - magnesium stearate, corn starch, sucrose. The capsule shell consists of titanium dioxide, gelatin, yellow iron oxide, water.
The drug is available in blisters containing fourteen or twenty-eight capsules and packed in cardboard boxes.
There is another form of release of this drug - suspension. AT pharmacy network it can be purchased without a prescription. This medicine should be stored at a temperature not exceeding 30ºС. It must be kept in a place where small children cannot enter.
For Ercefuril indications for use are the following cases:
- the patient develops symptoms of acute diarrhea caused by bacterial infection and proceeding without an increase in temperature in a patient or intoxication;
- bacterial intestinal lesion unexplained nature;
- gastroenteritis and dysentery.
The main component of the drug, nifuroxazide, blocks various enzyme reactions in bacteria and, when used for therapy, acts as a bacteriostatic agent, and when used high doses renders bactericidal effect. Good suppression of gram-positive microorganisms.
The drug does not cause the development of dysbacteriosis, and bacteria cannot develop increased resistance to it. The main medicinal ingredient gastrointestinal tract it is not adsorbed to other organs, but remains in the intestinal lumen and destroys invading microorganisms. From this organ, when the drug is removed from the body, 20% of nifuroxazide is released unchanged, and the rest leaves the intestine chemically transformed.
Contraindications and side effects for this medicine
Ercefuril should not be used in the following cases:
- a sick child who is under six years old;
- the patient is a pregnant woman;
- if a person has developed a high intolerance to fructose derivatives, there is a deficiency in the blood of sucrase and isomaltase in the presence of sucrose in the preparation itself;
- during the syndrome of glucose-galactose malabsorption;
- with hypersensitivity to the main or auxiliary components, which are part of the drug;
- do not use the suspension for the treatment of premature babies or infants under 1 month of age
Side effects of Ercefuril can manifest themselves in this form:
- allergic rashes on skin sick;
- symptoms of urticaria;
- the appearance of Quincke's edema;
- development of anaphylactic shock.
Cases of overdose have not yet been noted. When interacting with ethanol, it can lead to the development of hypersensitivity in the patient to the components of Ercefuril.
Do not use this medication in conjunction with antidepressants or in combination with drugs that lead to the development of a withdrawal syndrome.
Since there are no reliable data on the effects of Ercefuril on pregnant women, it is recommended not to use this drug for treatment. But if there is an emergency, then during pregnancy you can use this medicine only if the benefit to the expectant mother far exceeds possible harm for the fetus. Such therapy is carried out under the strict supervision of the attending physician.
For breastfeeding mothers, it is possible to use this drug, but only in the form of a short therapeutic course.
The medicine has no effect negative impact per person while driving or while dangerous species work, does not affect performance during activities related to concentration.
Dosage and special instructions for treatment with Ercefuril
This medication is for internal use only in children over six years of age and adults. When using it, you need to drink plenty of water. The dosage of the drug is determined by the attending physician, depending on the severity of the patient's diarrhea. The dose must be divided into several parts (usually 4) throughout the day - this is easy to do, since the capsule contains a certain amount of powder. Total duration treatment course the drug Ercefuril is about a week.
If a patient develops bacterial diarrhea, and symptoms of a serious systemic lesion appear, for example, body temperature rises sharply, general weakness, and the patient's condition worsened, intoxication appeared along with the infection, then instead of Ercefuril it is recommended to use antibacterial drugs that have good diffusion.
In cases where the patient has a pronounced prolonged diarrhea, and at the same time he refuses food, or he has severe vomiting, doctors may recommend giving him intravenous fluids and electrolytes to help him rehydrate.
If during the treatment course, diarrhea does not go away for two days, then doctors may review the treatment method and inject the patient with fluid and electrolytes intravenously or orally. The volume of these infusions is determined by the severity of diarrhea, clinical condition patient and his age.
The suspension can be used by both pregnant women and breastfeeding mothers. During treatment with this form of Ercefuril infants should be removed prior to treatment possible deficit the infant has enzymes that break down sucrose.
The problem of intestinal infection is relevant for children of any age, but especially for preschoolers. In such a situation, there are many nuances:
- medicine should be efficient enough to clinical symptoms infectious disease disappeared quickly;
- no less important is the safety of the drug in terms of the risk of systemic side effects and negative impact on the natural intestinal microflora;
- for parents little patient important is comfortable shape the release of the medicine so that the child does not refuse to take the required dose.
Almost all of these requirements are met by the drug "Ersefuril", the active substance of which is nifuroxazide. Instructions for use contains detailed description pharmacodynamics and pharmacokinetics of this drug, but parents are more interested in the practical aspects and features of the action of this drug.
When the drug is prescribed and its mechanism of action
The active substance - nifuroxazide - is a representative of the group of nitrofurans, which are also called intestinal antiseptics. In average therapeutic concentrations, it has a bacteriostatic effect, in higher, close to the borderline - bactericidal. The mechanism of its action is to disrupt the processes of tissue respiration of the microbial cell and its subsequent death.
The active substance of the drug "Ersefuril" is quite aggressive against most pathogens of gram-positive and gram-negative intestinal infections, such as staphylococcus aureus, salmonella, shigella, pseudomonads, klebsiella, that is, those that most often cause diarrhea in childhood. To a lesser extent, the drug "Ersefuril" is effective against Pseudomonas and Proteus, however, these microbial agents cause enough severe course intestinal infection, which requires the appointment of systemic antimicrobial agents.
An important advantage of the drug "Ersefuril" is its metabolic neutrality. Nifuroxazide is practically not absorbed through the intestinal mucosa, but acts only inside its cavity, where it is nai large quantity microbial cells. A significant part of the drug is excreted from stool unchanged, bypassing the liver and other internal organs. The remaining metabolites of the drug "Ersefuril" are inactive and are excreted in the urine. These features allow the use of this drug in children with chronic diseases kidneys and liver.
Reviews about the active substance of the drug "Ersefuril" on numerous Internet resources are quite contradictory. Enough a large number of mothers who use nifuroxazide as an effective and safe remedy with any intestinal infection in a child of any age. On the other hand, a considerable number of parents speak negatively about the results of treating the symptoms of an intestinal infection with this drug.
Children's doctor Evgeny Olegovich Komarovsky is also quite skeptical about the active substance of the Ersefuril drug. In his books, he writes about the lack of proven effectiveness of the active substance nifuroxazide, as well as the limitation of its use in pediatric practice in many Western countries. However, Dr. Komarovsky does not deny the possibility effective application the drug "Ersefuril" for a number of intestinal infections.
Indications
The indication for the appointment of the drug "Ersefuril" is almost any intestinal infection.It is this remedy, which is quite neutral with respect to tissues and organs. human body, can be used as a first-line drug when the exact pathogen is not known. Among the indications the most significant are:
- diarrhea of infectious origin in children of any age;
- chronic colitis and enterocolitis;
- complex treatment of intestinal dysbacteriosis.
Like any other antimicrobial agent, before taking Ercefuril, you must consult your doctor and get a prescription.
Contraindications
Quite traditional and few in number. These include:
- hypersensitivity to nitrofurans and other components of drugs;
- Availability allergic reactions in the history of the child to any nitrofurans.
A limited list of contraindications allows you to confidently use the drug "Ersefuril" in most children of any age.
Release form
The pharmaceutical company manufacturer of the drug "Ersefuril" produces two forms of it: capsules and suspension. Gelatin capsules reliably keep the active substance from damaging effects gastric juice Thus, the drug begins to act where necessary - in the intestinal lumen.
Suspension with a pleasant banana taste is more suitable for babies who cannot swallow enough large sizes capsule.
Dosages
The minimum course of treatment with Ersefuril is 5-7 days. The dosage is determined by the age of the small patient. Capsule contains 200 mg active substance, daily throughout the course of treatment, a single dose of this drug is taken in the morning and evening.
The measuring spoon that comes with contains holds 5 ml liquid form, equates to 220 mg of the active substance.
Side effects
Unlikely and quite rare. These include:
- moderate abdominal pain, nausea, diarrhea provocation;
- allergic reactions (as skin rash and itching, extremely rarely - an asthma attack).
You should not use the drug "Ersefuril" for children with lactase deficiency, as this drug contains lactose.
Analogues
An analogue is all means with the active substance "nifuroxazide". The most common include:
- Stopdiar
- Ecofuril
- Enterofuril
In favor of the drug "Ersefuril" - a solid reputation of the French pharmaceutical company - the manufacturer, which is a confirmation of the quality of the drug.
How to store the product
There are no particularly difficult requirements. It is necessary to store the drug "Ersefuril" (any form of release) in a dry place at room temperature.
Man in recent times tend to take a wide variety of medications. Among them, antipyretic drugs, as well as drugs to fight viruses, are very popular. No less often, consumers are interested in drugs for the correction of various intestinal pathologies. One of these drugs is Ersefuril. Reviews about it will be presented to your attention in this article. You will learn the features of the use of this medication. It is also worth saying separately how to give Ersefuril medicine to children.
Composition and characteristics of the drug
What is the medicine "Ersefuril"? Reviews of physicians, as well as instructions for use, report that the composition of the drug includes nifuroxazide in the amount of 200 milligrams. This substance is the main one. In addition to it, we can say about the following components: sucrose, magnesium stearate, corn starch. All these components are placed in a gelatin capsule, which usually has no effect on the human body and is excreted unchanged.
What is "Ersefuril"? Reviews of doctors say that this remedy can be called intestinal antiseptic. It affects pathogenic bacteria without disturbing the intestinal microflora.
In what situations is it applied?
What do expert reviews say about Ersefuril? Physicians report that this medicine used only for bowel diseases. Despite the fact that the drug is antimicrobial, it is not able to affect other organs.
The main indication for the use of the drug is acute diarrhea, which is caused by a violation of the microflora and the reproduction of pathogenic microbes. At the same time, they may be assigned different forms medication. It all depends on the condition of the patient and his age.
Contraindications for use
If you have contraindications to the use of the drug "Ersefuril", analogues of the drug will be your salvation. However, only a doctor should select them and prescribe a suitable correction scheme. What is a contraindication to the use of the drug?
The drug should not be used for hypersensitivity to the constituent components. At the same time, people prone to allergies should also refrain from such a correction. Tablets are not prescribed for children under the age of six years. "Ersefuril" (syrup) is not recommended for children under four weeks of age.
How is the medicine used?
In the treatment of diarrhea and pathology in the intestines, the drug is taken in one capsule. The frequency of use of the drug is four times a day. In this case, the daily dose of the drug should not exceed 800 milligrams of the active substance.
For children over the age of six, the medicine is recommended to be taken three times a day. while the dose of the drug remains the same as in adults - one capsule. Daily rate does not exceed 600 milligrams.
For children under six years of age, the drug is prescribed in the form of a suspension. The dose is selected based on the age and weight of the patient. At the same time, sometimes doctors are allowed to give capsules to children, previously dissolved in water. To do this, open the shell and pour the resulting powder with one teaspoon of water. It is worth recalling that the use of the capsule shell is optional. It is intended only for the convenience of taking the drug.
Features of use
During treatment with this remedy, it is necessary to simultaneously maintain drinking regimen. To do this, you need to drink at least two liters of plain water. If there is severe diarrhea with vomiting, then additional salt formulations can be used. These include Regidron. For children, the dose of water drunk should correspond to the mass of fluid lost. Otherwise, everything can end with dehydration, which is very dangerous for babies. Older people should also stick to a similar scheme and drink as much simple liquid as possible to make up for its deficiency.
The drug can be used during pregnancy and lactation. All due to the fact that the active substance works exclusively in the intestines and stomach. It is not absorbed into the blood, and therefore, cannot cause any harm to the unborn or newborn baby. It is worth noting that independent use medication during this period is fraught with consequences. Be sure to consult with a gynecologist and choose the appropriate regimen for taking the drug.
Reviews about the medicine
What do consumers say about the drug? Patient reviews are mostly positive. Users claim that the effect of the correction occurs immediately. Diarrhea stops within a few hours after the first dose of the drug.
Doctors testify that it is necessary to use the medication even after the complete disappearance of symptoms. In this case, the course of correction should not exceed one week. Doctors report that the drug does not affect the intestinal microflora in any way. It does not disturb the balance of beneficial microorganisms. At the same time, the agent acts on the pathogenic flora, preventing further reproduction of bacteria and removing them from the body.
Pharmacists and pharmacy workers they report that the price for Ersefuril is quite affordable. It can be purchased by almost everyone. It is worth noting that this medicine contributes to the preservation of its own flora while destroying microbes, while others antibacterial drugs completely inhibit the growth of beneficial microorganisms and bacteria. After such courses, the patient has to take drugs that help restore normal microflora.
"Ersefuril" or "Enterofuril"?
Quite often, patients have this question. In fact, the drug "Ersefuril" has other analogues. However, "Enterofuril" is its complete substitute. Their composition is completely identical. The dosage of both drugs also coincides.
If the pharmacy chain does not have one of the described drugs, then you can safely take another one. All adverse reactions, indications and method of use are the same. The price category of these medicines is approximately the same. How much does the medicine cost?
Price category
For the drug "Ersefuril" the price is approximately 500 rubles. For this amount, you can buy 14 capsules, each containing 200 milligrams of the active ingredient. If you need more tablets, the manufacturer offers a pack of 28 capsules. Such a pack will cost about 800 rubles.
As you can see, a large pack contains twice more pills. However, its price is not much higher than that of a small package. That is why it is more profitable to purchase more capsules.
Summarizing
You have learned a lot about Ersefuril. Be sure to read the instructions for use before starting treatment. At the same time, it is necessary to take into account the prescription of the doctor and his recommendations for admission. If unexpected reactions occur, stop treatment immediately and consult a specialist. Also, if there is no effect from the correction for more than three days, you should seek help from doctors. Be healthy!
Good day! Today my review is about effective means with diarrhea of bacterial origin - about
I have been using this drug for several years now. I first learned about him five years ago, when our family was completely mowed down. intestinal virus including my six-month-old son. Everyone's condition was worse than ever. Vomiting, diarrhea, high fever. Moreover, the diarrhea was unbridled. The main thing was not to run, but to convey. Ersefuril came to the rescue. This drug based on nifuroxazide at a dosage of 200 mg helped all of us within a few days. Tangible effect I felt it on myself after taking the first capsule. Since then, Ercefuril has always been in our home first aid kit, because immunity to rotavirus infections is not developed, and you can get infected with it again and again, especially if there are children in your family. True, the intestinal virus should leak in subsequent times already more mild form. But nevertheless, you can’t do without Ercefuril.
Basic information
Name - Ercefuril (Ercefuryl)
Active substance - Nifuroxazid (Nifuroxazidum)
A07AX03 Nifuroxazide (ATC)
A detailed comparison of Ercefuril and Enterofuril can be read.
Manufacturer - Sanofi aventis (Sanofi Aventis), France
6 boulevard de l "Europe, 21800, Quetiny, France.
Information from the barcode confirms that Ercefuril is produced in France. The first three digits 358 in the barcode indicate just this European country.
Release form
Ercefuril is produced only in the form of capsules in a single dosage of 200 mg.
Capsules are packed in a blister of 14 pieces.
Depending on the number of plates included in the package, Ercefuril is sold in packs of 14 or 28 capsules. I usually immediately take the package of the maximum configuration.
The blister is made of PVC and aluminum foil.
Contains gelatin capsules number 1 yellow color consisting of two parts.
The capsules are impressive in size, but I had no problems swallowing them.
Inside the capsule - the smallest powder of bright yellow color.
Purchase includes detailed instructions to the preparation and the declared number of capsules.
Recently, due to the growth of the euro, the price of Ercefuril in pharmacies has jumped significantly. So a pack of 14 capsules as of October 2015 in online pharmacies is in the area 500 rubles, from 28 - about 800 rubles.
As mentioned above, I try to always buy Ercefuril in the amount of 28 capsules. This is also cost-effective in terms of the cost of one capsule and you do not constantly need to run to the pharmacy.
Compound
The composition of Ercefuril is quantitative ratio nifuroxazide and excipients. The dosage of one or another component is given in the instructions in milligrams.
Pharmacological properties and metabolism
Ercefuril is an antimicrobial agent.
Indications for use
Acute bacterial diarrhea that occurs without worsening the general condition, fever, intoxication (in addition to adequate severity of diarrhea, rehydration by ingestion of liquids and electrolytes orally or, if necessary, their intravenous administration).
- with diarrhea - only when it is unbridled or accompanied by fever,
- with vomiting - in any, even her single case.
By the way, a characteristic phenomenon in rotavirus infection, in addition to disorders of the gastrointestinal tract, is even a slight reddening of the throat. After all, it is transmitted by airborne droplets. This is its main difference from banal poisoning.
With ordinary poisoning or diarrhea on nervous ground reestablish correct work bowels will help Imodium or Loperamide.
Contraindications
- hypersensitivity to nitrofuran derivatives or any excipients drug;
- pregnancy;
- fructose intolerance, glucose-galactose malabsorption syndrome or sucrase and isomaltase deficiency (due to the presence of sucrose in the preparation);
- children's age up to 6 years.
For children with similar symptoms usually appoint Enterofuril in the form of a suspension. This medicine is also always present in our first aid kit.
Dosage and administration
- 4 tablets per day for 5 days.
To be honest, I take Ercefuril differently, 4 or 3 tablets a day until the first successful trip to the toilet, i.e. no more than 2-3 days. But everyone's body is different, and it's better to drink this intestinal antibiotic the prescribed amount of time to consolidate the result, especially if rotavirus infection accompanied high temperature and vomiting.
Side effects and overdose
Allergic reactions such as skin rashes, urticaria, angioedema, anaphylactic shock.
Use during pregnancy and during breastfeeding
Shelf life and storage conditions
The shelf life of Ercefuril, in my opinion, is very long. It is 5 years old! During this time, it will not be difficult to use the tool.
The expiration date is indicated on the packaging of the medicinal product.
