The secret action of gonadotropin on the body of a man. Chorionic gonadotropin: instruction, description

Healthy body in men it is able to heal itself and rid itself of various problems. His regeneration and Eternal youth the male body depends on full-fledged work germ cells in the testicles and testosterone production. You can restore your health, get rid of pain, get a lot of energy by using chorionic gonadotropin for men. Reviews of people who have experienced its effect on themselves help to gain positive attitude before starting treatment.

What drug to choose to start therapy?

Chorionic gonadotropin is a special hormone of the placenta. It simultaneously includes the properties of the luteinizing hormone synthesized in the pituitary gland. The active substance of the drug is choreogonadotropin. It is used in medicines manufactured under different names UK, France, Germany:

"Gonacor".
"Pregnil".
Ecostimulin.

All of the above drugs are capable of:

increase the production of sex steroids;
regulate spermatogenesis;
develop secondary sexual characteristics.

The drug is used in men with altered functions of the sex glands with the development of disorders in the hypothalamic-pituitary system. In boys, chorionic gonadotropin is prescribed for late puberty, cryptorchidism, and. Men use the drug in violation of the formation of spermatozoa in germ cells.

The active ingredient, chorionic gonadotropin, is available in the form of solutions or dry powder, in ampoules or vials. The therapeutic dose of the drug is set biologically, by studying violations in the analysis of the sperm of a sick man.

At what pathology in men is gonadotropin used?

The doctor prescribes the drug for the pathology of the genital organs, found in the male body during the examination. The use of gonadotropin for treatment brings rapid and nice results. Chorionic gonadotropin is prescribed for a course of therapy and, if necessary, supplemented with other drugs that have a general strengthening effect, vitamins,.

Often men complain about the lack of hair male type on the face and body. Their testosterone levels are low, several times less than normal. The drug, prescribed by a specialist, corrects the production of testosterone, affecting the sex cells.

Gonadotropin after a course of treatment in men causes headache attacks that last up to 30-60 minutes and occur repeatedly during the day.

The interest of athletes in gonadotropin

Athletes use gonadotropin to participate in many types of sports. Some of them do not note the normalizing effect of gonadotropin on the state of their body, but at the same time great attention building muscle mass.

Many athletes adjust their training and nutrition regimen while taking the drug. AT end result they are having moderate growth muscles of the whole body. Athletes take gonadotropin to restore the shape of the testicles and their original size.

Injectable forms of gonadotropin do not negatively affect men's health and positively influence the development of secondary sexual characteristics. In men, there is a high amount of testosterone, formed as a result of the use of gonadotropin, and the maximum concentration of anabolics in the blood.

In many men, as a result of intensive sports combined with simultaneous reception anabolics, there is a decrease sexual attraction. Experienced Athletes familiar with similar problem and take appropriate measures in advance to resolve the psychological difficulties that have arisen. Gonadotropin is used by them regularly, at regular intervals. As a result of the course of treatment, spermatogenesis and libido are completely restored.

The male body needs strictly a certain reception medications coinciding with the end of steroid hormones. Gonadotropin in short time increases the amount of testosterone, but is not able to completely slow down the loss of muscle mass and strength at the end of steroid treatment. As a result of this process, athletes experience mental instability. To relieve painful symptoms, they use gonadotropin, prescribed by a doctor during the period of complete cessation of hormones.

The male body after the use of gonadotropin completely restores the amount of testosterone in the testicles. However, it does not have a significant effect on the hypothalamus and pituitary gland, and testosterone reduces the production of luteinizing hormone.

After the end of the course of treatment with gonadotropin, athletes must go through a recovery period. They can correct impaired spermatogenesis associated with long-term therapy steroid hormones. Men bodybuilders celebrate positive influence gonadotropin on muscle hardness, the volume of subcutaneous fat.

In some men, the amount of subcutaneous fat layer does not decrease after using the drug, appetite or fat distribution does not change.

An important quality of gonadotropin is that the drug has a biphasic effect.

The main stages of the action of gonadotropin on the human body

After taking the drug in any dosage, a two-phase increase in the amount of testosterone in the body of a man is observed. The level of elevation depends on the dose of medication used. The main purpose of administering gonadotropin after taking steroids is to maintain muscle mass levels.

In men, gonadotropin, when used in doses prescribed by a doctor, does not cause dependence on the drug. In some patients, antibodies are formed in the body that affect the effectiveness of the drug. The course of treatment is established by the attending physician and is strictly individual for each patient. Positive results manifest for a long time, due to the fact that gonadotropin promotes the rapid division of germ cells and affects their number.

In some cases, in men who have used the drug for a long time, the testicles stop their function, reducing the production of luteinizing hormone. As a result of treatment, hypofunction of the gonads occurs.

In athletes who have used the hormone for a long time, the body stops producing gonadotropins for a long time. In some cases, in the testicles of a man, gonadotropic receptors are completely destroyed and the testicles become immune to the hormone.

Side effects associated with the introduction of human chorionic gonadotropin

The use of the drug causes the appearance of side effects similar to those after the use of testosterone. The level of estrogen in the male body increases depending on the amount of testosterone and causes the growth of the mammary glands in the stronger sex. Most frequent side effects after the administration of the drug, they may appear at any stage of its use and manifest as:

increased sex drive;
the presence of acne;
delay mineral salts and water in the body.

Violation of the water and mineral balance leads to the appearance of edematous muscles of the body. In men with high testosterone levels, after additional introduction gonadotropin is disturbed water balance and unhealthy fullness develops.

Testosterone in their body is converted into female sex hormones, estrogens. In young men, after the use of the drug, bone growth stops, the blood pressure, the timbre of the voice is disturbed. Some men experience nausea, vomiting, a feeling of lightheadedness, unmotivated fullness after using the drug.

Aging men during menopause suffer from a drop in testosterone levels by 30%. They need to correct the level of the hormone in the blood and go to the doctor for a course of treatment with gonadotropin.

In patients prone to hair loss, therapeutic effect hormone prevents baldness. The drug is used sparingly, with strict medical supervision. Self-medication can seriously harm a man's body. As a result of improper therapy, he has cosmetic defects:

acne;
acne;
sebum plugs.

When prescribing chronic gonadotropin, the patient should be aware of the possibility of oncological process arising in rare cases after therapy.

Chronic gonadotropin is able to rejuvenate male body, improve the condition of all organs and systems, improve the quality of life.

Testosterone production plays important role in the functioning of the body of men and women. Chorionic Gonadotropin in the form of injections, according to the instructions for use, solves important task- increase its level in case of deviation from the norm. What other effect does the drug have, for what problems is it prescribed, how to use it correctly - about this in detail in the annotation.

What is human chorionic gonadotropin

This is the name of the hormone responsible for puberty, reproductive function. What is hCG for a woman's body? This is a substance that is actively produced after fertilization of the egg. Refers to gonadotropic hormones, but differs in the sequence of amino acids. Excess hCG norms confirms pregnancy. This determines the pharmacy test that reacts to its content in the urine. Increasing hCG in non-pregnant women may indicate the presence of malignant tumor.

The introduction of the drug causes an increase in the production of sex hormones in men, the development of secondary sexual characteristics, and stimulates the activity of spermatozoa. During use in women:

increased production of estrogen, progesterone by the ovaries;
ovulation is stimulated;
the function is normalized corpus luteum;
goes proper development placenta.

Composition and form of release

Gonadotropin is available as two components, packaged in a box. Each contains 5 medicine kits. The composition has:

Solvent - saline sodium chloride with a concentration of 0.9%.
Sterile glass vial containing a substance in the form of a powder white color, contains 500 or 1000 IU - units of action. The basis is human chorionic gonadotropin obtained from biological material, past process lyophilization - drying in vacuum. Auxiliary Component- mannitol.

pharmachologic effect

Recombinant human chorionic gonadotropin - a hormone that is produced by the placenta, is excreted from the body with the urine of a pregnant woman, from where it is extracted to obtain a medicine. When administered as an intramuscular injection, it produces healing effect. Active substance:

enters the bloodstream after 15 minutes;
distributed in tissues;
excreted in the urine;
half-life - 8 hours.

The drug Gonadotropin refers to the hormones of the hypothalamus:

In women, it normalizes ovarian function, activates the formation of the corpus luteum, stimulates the production of progesterone, estrogen. The application contributes to the luteinizing action - the correct process of ovulation.
Gonadotropin for men helps the formation of secondary sexual characteristics, stimulates spermatogenesis. The tool accelerates the lowering of the testicles into the scrotum in the treatment of cryptorchidism, activates the production of the hormone testosterone.

Indications for the use of chorionic gonadotropin

infertility as a result of hormonal disorders;
late puberty of girls and boys;
violation of the function of reproduction of offspring;
decreased synthesis of sex hormones.

For men

A decrease in gonadotropin levels creates serious problems in the body. HCG in men is responsible for the activity of spermatozoa, the production of sex hormones. The tool is prescribed if:

cryptorchidism;
violations reproductive function;
insufficient activity of the sex glands;
testicular hypoplasia;
spermatogenesis disorders;
phenomena of eunuchoidism;
hypogenitalism.

For women

The hormone gonadotropin plays an important role in the treatment female infertility caused by dysfunction of the corpus luteum. It helps to get pregnant in the absence of ovulation, when the follicle cannot burst to fertilize the egg. Indications for the use of the drug by women are:

ovarian dysfunction;
uterine bleeding in childbearing age;
the threat of miscarriage in the first trimester;
violations, absence menstrual cycle.

Instructions for use of chorionic gonadotropin

The drug is prescribed intramuscularly. How to inject gonadotropin? The technique, the duration of the course, is determined by the doctor, which depends on the disease, the planned result. The duration of therapy is up to 45 days. There are features:

In men, treatment with the drug is used 3 times a week for a month, the dose is up to 3000 IU. This is followed by a six-week break and new course. This can happen up to 3 times a year.
The drug is prescribed to boys with cryptorchidism with a dosage of 1000 IU twice a week for a month and a half. There are several courses.

Treatment for women depends on the problem:

to stimulate ovulation - one injection of 10,000 IU;
with a threat of miscarriage, 10,000 IU are administered for the first time, then twice a week, 5,000 IU each;
in case of anovulatory dysfunction high level estrogen injection is carried out on the 10-12th day of the menstrual cycle, the dose is 3000 IU, 2-3 injections with an interval of several days;
to normalize the production of the corpus luteum - up to 5000 IU for 3, 6, 9 days after ovulation.

In bodybuilding

The use of gonadotropin by athletes, along with the use of steroids, has been controversial. Professionals do not confirm high results after taking hormonal drugs. Gonadotropin in bodybuilding large dosages provokes dysfunction of the testicles, hypothalamus, pituitary gland. There are groups of bodybuilders using the remedy long time and celebrating:

obtaining a beautiful muscle relief;
increase endurance in training;
stimulation of spermatogenesis;
increase in sexual desire.

During pregnancy

Caution should be exercised in the treatment of gonadotropin during pregnancy. Gynecologists prescribe medication in exceptional cases, the course is carried out in stationary conditions under the strict supervision of a physician. When using the drug, an adverse effect on the body of a pregnant woman is possible:

increased risk of miscarriage;
development multiple pregnancy.

special instructions

Instructions for use require to exclude the interaction of gonadotropic hormones with glucocorticosteroids. Prolonged administration of the drug can lead to the formation of antibodies to it. special instructions during application:

it is not recommended to drive a car, work on units that require high concentration attention;
combination with alcohol is not recommended;
in the treatment of men, the level of androgens rises - medical supervision is necessary.

The annotation to the drug stipulates important points:

solution for injection prepare before use, storage is unacceptable;
if ovarian hyperstimulation syndrome occurs, treatment must be stopped;
you need to stop feeding during treatment during lactation;
with prolonged administration, the functions of the pituitary gland decrease;
the medicine can not be used after the expiration date.

Side effects of human chorionic gonadotropin

It is unacceptable to self-medicate, with an overdose, serious side effects are inevitable. Unpleasant symptoms can affect many systems. In this case, the reactions of the body are observed:

weakness;
depression;
irritability;
headache;
fatigue;
anxiety;
weight gain;
allergy;
the formation of antibodies;
soreness at the injection site;
breast enlargement;
fever;
rash;
swelling.

It is not excluded the appearance side effects from the side genitourinary system in violation of the administered dose of chorionic gonadotropin:

in women - multiple pregnancy, ovarian hyperstimulation syndrome, the appearance of ovarian cysts, peripheral edema;
in boys - early puberty, the formation of acne;
in men - atrophy of the seminiferous tubules, hyperplasia prostate, enlarged testicles, penis, increased sensitivity of the nipples.

Contraindications for chorionic gonadotropin

Instructions for use stipulate contraindications to taking the drug. This must be taken carefully to avoid trouble. It is forbidden to use the drug in case of:

high sensitivity to components;
cancerous tumors genital organs, mammary gland;
thrombophlebitis;
pituitary tumors;
hypothyroidism;
hypertension;
migraine;
epilepsy;
adrenal insufficiency;
premature puberty in boys;
heart failure, renal dysfunction in men.

Among the contraindications for the administration of the drug there are additional restrictions for women:

improperly formed genitals that prevent pregnancy;
ovarian failure;
fibrous tumor of the uterus incompatible with pregnancy;
bleeding, discharge of unknown origin;
severe obesity;
breastfeeding period.

Analogues

Gonadotropin belongs to the group of drugs that regulate hormonal disorders. There is medications With similar action, which are only suitable for solving the problems of the female body associated with a low concentration of hCG. These include Puregon, Ovitrel, Pergoveris. Hormonal remedies used in the therapy of men and women:

Ecostimulin;
Horagon;
Prerotten;
Menopur;
Prevasi.

The price of chorionic gonadotropin

The sale of Gonadotropin and analogues is carried out by pharmacies. You can order hCG preparations through websites and buy in online drug stores. The cost depends on the means, dosage, it is possible to increase it due to transportation costs. The difference in prices for pharmacies in Moscow is in rubles:

	Units of action ME	Dosage, ml	Amount	Price spread, r.
Chorionic gonadotropin
Puregon lyophilisate
Ovitrel, 250 mg

Chorionic gonadtropin (abbreviated as hCG or hCG) is a glycoprotein, a hormone of the placenta, which includes two subunits α and β (alpha and beta subunit of chorionic gonadotropin). The alpha subunit is completely homologous (has a similar origin) with the alpha subunits of thyrotropic, follicle-stimulating, luteinizing hormones, and the beta subunit of human chorionic gonadotropin is unique to this hormone, which is how it differs from TSH, FSH and LH.

It is the beta subunit of chorionic gonadotropin that is the basis of the pregnancy test. Beta chorionic gonadotropin begins to be released in the first weeks of pregnancy, by 7-11 weeks its amount increases several thousand times, after which it gradually decreases. That is why the analysis for chorionic gonadotropin during pregnancy and monitoring its level is important - its decrease or slowdown in production may indicate ectopic pregnancy or threatened miscarriage.

In addition, a woman who cannot become pregnant should be tested for antibodies to chorionic gonadotropin - they block the activity of hCG, which causes a decrease in the level of placental lactogen, progesterone, estradiol. It is chorionic gonadotropin that prevents fetal rejection, its intrauterine death, which is why it is important to monitor its level. Women with antibodies to chorionic gonadotropin in the blood are recommended to undergo plasmapheresis, apply in vitro fertilization.

Usually, chorionic gonadotropin is determined during pregnancy only, which is considered the norm, but this does not mean that the analysis for beta chorionic gonadotropin is not done non-pregnant women and men. If hormone-producing tumors are suspected, an analysis is prescribed that detects chorionic gonadotropin in the blood - for men and women who have not confirmed pregnancy.

In addition to the hormone known medical preparation chorionic gonadotropin. Its use is practiced for the treatment of violations of the functionality of the reproductive system of women and men.

Get this hormonal drug from the urine of pregnant women. Main pharmachologic effect recombinant human chorionic gonadotropin - stimulation of the production of sex hormones in the tissues and ovaries, ovulation, spermatogenesis, development of secondary sexual characteristics and genital organs.

In what cases is chorionic gonadotropin prescribed? The instruction says that the drug is effective for:

ovarian dysfunction;
dysmenorrhea;
anovulatory infertility;
corpus luteum deficiency;
the threat of miscarriage;
habitual miscarriage.

A good result is observed in cases where it is used with auxiliary reproductive techniques oh chorionic gonadotropin - there are reviews about it.

Men are also prescribed chorionic gonadotropin for:

hypogenitalism;
hypoplasia of the texticles;
eunuchoidism;
cryptorchidism (undescended testicle into the scrotum);
sexual infantilism;
pituitary dwarfism;
adiposogenital syndrome;
azoospermia;
oligoasthenospermia;
as well as genetic disorders.

Chorionic gonadotropin is produced in the form of a solution (or a lyophilisate for its preparation) for injection.

Inject hCG intramuscularly. On forums devoted to pregnancy issues, they often ask whether it is possible to inject chorionic gonadotropin themselves - reviews say that it is possible, but only if the woman herself or her relatives know how to do it right intramuscular injections. Such a need arises most often due to the fact that long courses are prescribed, and it is not always possible to visit the treatment room in the clinic.

In order to inject HCG, you need to know the allowable dosages.

How much is human chorionic gonadotropin produced? The pharmacy can offer the drug in such dosages:

chorionic gonadotropin 500 units;
chorionic gonadotropin 1000 units;
chorionic gonadotropin 1500 units;
chorionic gonadotropin 5000 units;
chorionic gonadotropin 10000 units.

Dosages and methods of application of human chorionic gonadotropin

Here will be given the standard dosages in which chorionic gonadotropin is prescribed and pricked. A pharmacy, Internet forums, and even instructions cannot be the main consultants in this matter, especially if we are talking about maintaining the pregnancy or treating infertility.

Improper treatment can aggravate the situation and delay recovery, lead to serious undesirable consequences. To stimulate ovulation, women are prescribed a single dose of chorionic gonadotropin 5000 or chorionic gonadotropin 10,000 IU.

To stimulate the function of the corpus luteum on days 3-6-9 of ovulation, chorionic gonadotropin 1500 or chorionic gonadotropin 5000 IU is prescribed.

In the course of reproductive measures for superovulation, a woman, after stimulating the growth of multiple follicles, is injected once with about 10,000 IU of chorionic gonadotropin. The egg is collected 34-36 hours after the CG injection.

To maintain pregnancy (with habitual miscarriage), a woman is prescribed CG injections as early as possible (no later than 8 weeks) and the drug is administered up to 14 weeks inclusive. On the first day of therapy, chorionic gonadotropin 10,000 IU is injected, and on subsequent days, chorionic gonadotropin 5,000 IU is injected twice a week.

If there is a threat of miscarriage, first inject 10,000 IU, and after that - chorionic gonadotropin 5,000 IU twice a week. You can start therapy, as in the previous case, only until the 8th week of pregnancy, and continue until the 14th week.

A good result is given with a delay in the sexual development of boys, chorionic gonadotropin. Treatment involves the appointment of 3000-5000 IU hCG per week for three months. Men with delayed sexual development are prescribed chorionic gonadotropin 500, chorionic gonadotropin 1000 units, 1500 units or 2000 units per day for 1.5-3 months, 2-3 times a week.

For the treatment of hypogonadotropic hypogonadism, chorionic gonadotropin is prescribed at a dosage of 1500-6000 IU, in combination with menotropins - once a week. With cryptorchidism, boys under 6 years of age are injected with chorionic gonadotropin 1000 units or 500 units twice a week for 6 weeks. Boys after 6 years of age are injected with 1500 IU of chorionic gonadotropin twice a week, also for 6 weeks.

In women, the drug can cause ovarian hyperstimulation syndrome, and, as a result, the formation of cysts, hydrothorax, ascites, thromboembolism. In men and boys, chorionic gonadotropin can cause temporary transient enlargement of the breast, prostate gland, acne, water retention.

Boys may experience a change in behavior - the same that usually occurs in the 1st phase of puberty. Similar symptoms disappear after the end of treatment.

Contraindications to the use of human chorionic gonadotropin

The use of chorionic gonadotropin is contraindicated in hormone-dependent tumors, cryptorchidism of organic origin (such as caused by a hernia in the groin, an operation in the groin, wrong position testicles), with hypersensitivity to chorionic gonadotropin.

Separately, I would like to highlight such a contraindication as the use of the drug chorionic gonadotropin in bodybuilding. Athletes inject themselves with hCG, as it increases the secretion of testosterone by the testicles, and, as a result, contributes to the recruitment of muscle mass.

But such use of CG is not justified: the drug is less effective than anabolic steroids and, in addition, large doses of CG are required to obtain the optimal result - more than 4000 IU per week. The use of the drug in such doses can cause irreversible damage functionality of the hypothalamus, pituitary gland and testicles.

HCG (human chorionic gonadotropin) is a hormone that in large numbers produced by the chorion of the embryo. This happens within a week after fertilization. A sufficient amount indicates normal developing pregnancy. Chorionic gonadotropin is also present in a small amount in the body of men and women who are not expecting a child. The drug containing this hormone is widely used in medicine for various purposes.

What is human chorionic gonadotropin and what is it responsible for? This substance belongs to gonadotropic hormones. It plays an important role in the body of men and women. This substance is on a par with luteinizing and follicle-stimulating hormones, but differs from them in structure. Human chorionic gonadotropin is a complex protein base in which carbohydrate elements are present. It mostly consists of amino acids.

Chorionic gonadotropin, produced in large quantities in the body of a pregnant woman, is excreted from her body in the urine unchanged. From there it is mined to create medicines that are subsequently used for various purposes.

Pharmacological properties of gonadotropin

A drug containing gonadotropin hormone has the following pharmacological properties:

promotes the synthesis of sex hormones female body that occurs in the ovaries. In men, the same process occurs in the testicles. Especially chorionic gonadotropin affects the production of testosterone;
promotes ovulation;
stimulates spermatogenesis in men;
provides normal functioning corpus luteum, which is especially important during pregnancy;
affects normal development genital organs in men and women, provokes the appearance of secondary sexual characteristics.

Indications for the use of the drug gonadotropin

Features of the use of gonadotropin is that they can eliminate many problems that are found in men and women. This drug is most often used to eliminate the decrease in sexual function, which occurs when there is a violation normal operation pituitary and hypothalamus.

The most common indications for the use of this drug are:

Simmonds syndrome, which causes severe hormonal disorders different kind;
necrosis of the pituitary gland observed after childbirth. This condition is a complication that occurs as a result of significant bleeding;
panhypopituitarism different type, regardless of the reasons for its occurrence;

adiposogenital dystrophy with emerging obesity, which is localized in the area of \u200b\u200bthe brain where the hypothalamus and pituitary gland are located;
dwarfism caused by insufficient function of the pituitary gland, which is accompanied by sexual disorders;
hypogonadism, accompanied by sexual dysfunction, the absence of normally developed genitalia;
infertility in women, which is associated with the absence of ovulation;

with delayed sexual development in men and women;
with threats of spontaneous abortion in the first trimester of pregnancy in the presence of a fetus that develops normally;
uterine bleeding in women of reproductive age;
to stimulate the descent of the testicles into the scrotum in children;
diagnosis of hypogonadism in the stronger sex.

The use of the drug gonadotropin in sports

Chorionic gonadotropin has anabolic properties. It is because of this that it began to be used in bodybuilding to gain muscle mass. Also, the drug containing this hormone affects the hypothalamus in a special way, which stimulates the reduction of body fat. The human body begins to use energy reserves more intensively, which causes the effect of losing weight. At the same time, the muscles do not undergo splitting, as can be observed with natural process without outside interference.

Recent studies by scientists indicate that the use of this drug may be hazardous to human health. Chorionic gonadotropin produces a much smaller effect on gaining muscle mass than taking other steroids that belong to the anabolic series. To get a tangible result, it is necessary to administer large doses of the drug, which negatively affects the functioning of the body.

Gonadotropin for men is indicated only in cases where there is high risk testicular atrophy due to use anabolic steroids. In this case, it is recommended to use drugs in the minimum dosage, which eliminates negative consequences for the body. They are taken after a long course of steroids (more than 1-2 months). At this time, it is also recommended to use vitamin complexes and lots of protein.

How to use the drug gonadotropin

Human chorionic gonadotropin is produced pharmaceutical companies in the form of a powder, which is intended for the preparation of a solution. To do this, a solvent (most often sodium chloride) is offered in the kit for the main drug. It must be introduced into an ampoule with powder, and then used for its intended purpose. The drug usually dissolves well within a few seconds. The resulting liquid is administered intramuscularly.

If the prepared solution is not completely used, then it must be moved to the refrigerator. Dry powder should be kept in a dark place out of the reach of children. Optimum temperature for this - no more than 20 ° C.

The half-life of the active substances of the drug is several hours. The result of using one injection lasts for a long time - about 5-6 days.

Permissible dosages of gonadotropin

Instructions for use of this drug indicate the optimal dosage:

women in the absence of ovulation, to stimulate this process with one injection - from 5000 to 10000 IU;
stimulation normal life corpus luteum - maximum dose 5000 U (used on certain days of the menstrual cycle);
during the IVF procedure during ovulation stimulation - 10,000 IU with one injection;
with habitual miscarriage (before 8 weeks of pregnancy) the entire first trimester - the first dose of 10,000 IU, then 5,000 IU 2 times a week;
with developmental delays in children (boys) - the maximum dose of 5000 IU for 3 months and more 1 time per week;
in case of violation of reproductive function in men - the maximum dose is 2000 IU 2-3 times a week for several months;
in the treatment of hypogonadotropic hypogonadism - the maximum dose is 6000 IU once a week;
to assess the functions of the testicles in the diagnosis of certain conditions - 5000 units once;
for lowering the testicles in boys under the age of 6 years - the maximum dose is 1000 IU 2 times a week for 1.5 months;
for lowering the testicles in boys over 6 years old - 1500 IU twice a week for 1.5 months;
with oligospermia - 5000 IU every week for 3 months.

Contraindications for use

Human chorionic gonadotropin is not used with therapeutic purpose in the following cases:

hyperprolactinemia;
ovarian cancer;
hypersensitivity to any component;
absence of glands reproductive system (congenital pathology, the result of the operation);
hypothyroidism;
menopause that came too early;
tumors of various types (pituitary or hormone-dependent sex glands);
thrombophlebitis;
lactation;
adrenal dysfunction;
obstruction of the uterine tubes.

Also with great care this remedy prescribed for hypertension, in adolescence, to treat people with kidney failure, bronchial asthma or frequent episodes of migraines.

Side effects of gonadotropin

Chorionic gonadotropin 1500 IU dosage or any other can provoke the following side reactions:

increased irritability;
pain at the injection site;
hyperemia;
allergic reactions different manifestations;
headache;
high fatigue;
depressive states;
inhibition of the normal functioning of the pituitary gland;
in women, when taken in huge doses, ovarian hyperstimulation syndrome is observed, in men - swelling of tissues, nipple sensitivity, gynecomastia, enlarged testicles;
with prolonged use in men, inhibition of sperm activity is observed.

Reception features

With increasing doses of the drug in women, ovarian hyperstimulation syndrome often occurs, which is accompanied by an increase in their size.

it dangerous state, requiring symptomatic treatment. Major Complications given state- ascites and hydrothorax. In the treatment of infertility, this remedy is often used in combination with menopausal gonadotropin.

In the treatment of men, the ineffectiveness of the drug at a high concentration of FSH has been proven. unfounded long-term use means leads to negative consequences. When treating children, premature puberty may occur. If the hormone is administered for cryptorchidism, degeneration of the genital organs sometimes occurs.

Long-term use may cause the formation of specific antibodies. This is a dangerous condition that leads to a decrease in the concentration of the hormone. immune system. During pregnancy, this leads to interruption or premature birth. If this remedy was used to stimulate ovulation, the likelihood of the formation of two or more eggs increases several times.

It should also be borne in mind that after discontinuation of the drug in both men and women for a week, a pregnancy test will show a false positive result.

Manufacturers

Chorionic gonadotropin is produced by several pharmaceutical companies under different trade names:

Moscow Endocrine Plant. It has generic name denoting the active substance;
Pregnyl. Contains chorionic gonadotropin 500, 100, 1500, 3000 U in one vial. Manufacturer - the Netherlands;
Profazi. Manufacturer - Switzerland;
Ovitrelle. Manufacturer - Italy.

The description of these drugs is identical. They have the same range of applications and side effects. The tablet as a therapeutic component is not used. All funds are ready or semi-ready solution for injection.

Registration number

Tradename: Chorionic gonadotropin

International non-proprietary name: chorionic gonadotropin.

Dosage form: lyophilizate for preparing a solution for intramuscular injection.

Compound: Active substance - chorionic gonadotropin 5000 IU, Excipients - mannitol (mannitol).

Description. Lyophilized white or almost white powder.

Pharmacotherapeutic group: Luteinizing agent.

ATX code: G03GA01

Pharmacological properties. The drug has a gonadotropic effect, mainly luteinizing. Stimulates the synthesis of sex hormones in the ovaries and testicles. Stimulates ovulation in women and spermatogenesis in men. Enhances the development of the genital organs and secondary sexual characteristics.

Indications for use. Hypofunction of the gonads in men and women, due to impaired activity of the hypothalamus and pituitary gland.
In women: anovulatory infertility, corpus luteum insufficiency (in the presence of estrogenic ovarian function), induction of superovulation during assisted reproductive techniques, recurrent miscarriage, threatened spontaneous miscarriage.
In men: hypogenitalism, eunuchoidism; testicular hypoplasia, cryptorchidism; adiposogenital syndrome, pituitary dwarfism, sexual infantilism; oligoasthenospermia, azoospermia.
With the aim of differential diagnosis cryptorchidism and anarchism in boys and to assess testicular function in hypogonadotropic hypogonadism.

Contraindications. Hypersensitivity to the components of the drug, pituitary tumor, hormonally active tumors of the sex glands (including androgen-dependent), absence of the sex glands (congenital or after surgery), early attack menopause, thrombophlebitis, lactation period, ovarian cancer, hypothyroidism, adrenal insufficiency, hyperprolactinemia, tubal obstruction.

Carefully: adolescence, ischemic disease hearts, arterial hypertension, chronic kidney failure, bronchial asthma, migraine.

Dosage and administration. The drug is administered intramuscularly.
Women for ovulation induction - 5000-10000 IU at once, for stimulation of corpus luteum function - 1500-5000 IU for 3-6-9 days after ovulation.
For the induction of superovulation during assisted reproductive measures - up to 10,000 IU once after the induction of the growth of multiple follicles, which is achieved as a result of stimulation according to the established scheme. The egg is collected 34-36 hours after injection.
With habitual miscarriage, the introduction begins immediately after pregnancy is diagnosed (but not later than 8 weeks) and continues until the 14th week of pregnancy inclusive: on day 1 - 10,000 IU, then 5,000 IU 2 times a week.
With the threat of spontaneous miscarriage (if the symptoms appeared in the first 8 weeks of pregnancy) - 10,000 IU initially, then 5,000 IU 2 times a week until the 14th week of pregnancy inclusive.
With a delay in the sexual development of boys - 3000-5000 ME 1 time per week for at least 3 months. For men - 500-2000 units 1 time per day 2-3 times a week for 1.5-3 months.
With hypogonadotropic hypogonadism: 1500-6000 IU (in combination with menotropins) 1 time per week.
For the purpose of differential diagnosis of cryptorchidism and anarchism in boys and for the purpose of assessing testicular function in hypogonadotropic hypogonadism, once - 5000 IU.
With cryptorchidism: under the age of 6 years - 500-1000 IU 2 times a week for 6 weeks; older than 6 years - 1500 IU 2 times a week for 6 weeks.
With idiopathic normogonadotropic oligospermia - 5000 IU weekly for 3 months along with menotropins. With oligo- and asthenospermia due to relative androgen deficiency, 2500 IU every 5 days or 10,000 IU once every 2 weeks for 3 months.

Side effect. Local reactions(pain at the injection site, hyperemia); allergic reactions; headache; increased fatigue; irritability; anxiety; depression; suppression of the gonadotropic function of the pituitary gland.
In women at combined treatment infertility (in combination with menotropins and clomiphene) - ovarian hyperstimulation syndrome. In men - fluid retention, edema, hypersensitivity nipples mammary glands, gynecomastia, enlarged testicles in the inguinal canal (with cryptorchidism).
As a result of long-term use of the drug in men, a decrease in the number of spermatozoa in the ejaculate was found.

Overdose. With an overdose of the drug in women, ovarian hyperstimulation syndrome may occur with an increase in their size due to ovarian cysts with the danger of their rupture, the appearance of ascites and hydrothorax. Its appearance may be indicated by symptoms such as a feeling of tension and pain in the abdomen, vomiting, diarrhea, difficulty breathing, weight gain. Treatment is symptomatic.

Interaction with others medicines . Chorionic gonadotropin is used in combination with menopausal gonadotropin in the treatment of infertility.

special instructions.
In men, the drug is ineffective in high content follicle stimulating hormone (FSH). With prolonged treatment or use in large doses in male adolescents with impaired physical and sexual development, premature puberty is possible. unreasonably long-term use drug for cryptorchidism, especially if indicated surgical intervention, can lead to degeneration of the gonads. Inhibition of FSH production due to stimulation of androgen and estrogen production contributes to seminiferous tubule atrophy.
Prolonged administration may lead to the formation of antibodies to the drug.
Increases the likelihood of multiple pregnancy. Possible erroneous results when using a pregnancy test during treatment with the drug and within 7 days after its cancellation.

Release form. Lyophilizate for the preparation of a solution for intramuscular injection 5000 IU in 5 ml vials.
5 vials with the drug in a blister pack and 5 ampoules of 1 ml of sodium chloride solution for injection 0.9% in a blister pack, together with instructions for using the drug and the solvent, are placed in a cardboard box.

Storage conditions. List B. In a place protected from light and out of the reach of children, at a temperature not exceeding 20 ° C.

Best before date. 3 years.
Do not use after the expiry date stated on the package.

Terms of dispensing from pharmacies. On prescription.

Manufacturer.
Federal State Unitary Enterprise "Moscow Endocrine Plant"
109052, Moscow, st. Novokhokhlovskaya, 25.