Anabolic steroid methandrostenolone: ​​recommendations and instructions for use. methandrostenolone side effects

Pharmacological properties

Pharmacological group: anabolic / androgenic steroids
Androgenic activity: 40-60
Anabolic activity: 90-210
Application: oral
Chemical names: 17a-methyl-17b-hydroxy-l,4-androstadien-3-one
l-dehydro-17a-methyltestosterone
Estrogenic activity: moderate
Progesterone activity: not significant

Description of Methandrostenolone

Methandrostenolone (Dianabol, Methandienone) is a testosterone derivative modified in such a way that the androgenic properties of the hormone (masculinization) are significantly reduced here, while the anabolic properties of testosterone (facilitating tissue construction) are preserved. Having a lower level of relative androgenicity than testosterone, Methandrostenolone is classified as an "anabolic" steroid, although some androgenic side effects still occur with its use.
This drug was developed for oral use, although in veterinary medicine it is used by injection. Dianabol is an orally administered anabolic/androgenic steroid used to enhance a person's physical performance.

Story

Methandrostenolone was first described in 1955. It was released to the US prescription drug market in 1958 under the brand name Dianabol by Ciba Pharmaceuticals.
Ciba developed the drug with the help of Dr. John Ziegler, a doctor for several US Olympic teams, including weightlifters.
Ziegler says that he first encountered steroids at the 1956 World Games, during which testosterone abuse was observed among Russian athletes. According to Ziegler, the hormone showed noticeable side effects, and one athlete had such severe prostatic hyperplasia that he was forced to urinate using a catheter.
When working with Ciba, a steroid (previously synthesized) was tested, which has a lower androgenicity compared to testosterone, while maintaining its anabolic properties, which was achieved by changing the basic chemical composition of testosterone so that its metabolism and pharmacokinetics in the body changed. With the help of Dr. Ziegler, Ciba brought to market one of the most effective oral "anabolic" steroids ever known, Methandrostenolone.
The success of the drug was swift and widespread.
With the help of this drug, Dr. Ziegler's athletes achieved significant career success in a short time. Ziegler was also reportedly quite impressed with the steroid's capabilities for some time. But in the early 1960s, it became clear that the advent of Dianabol triggered a big wave of doping in the sport. Dr. Ziegler's early drug recommendations of only 5 to 15 mg per day were most often ignored, and athletes developed their own, more aggressive (and likely more dangerous) dosing strategies. Dr. Ziegler soon became disillusioned with the drug's benefits, and eventually sided with the opposition on sports doping.
By 1967, about 10 years after the first use of Dianabol by his athletes, Ziegler begins to strongly condemn any use of anabolic steroids in sports.
As early as 1965, the FDA began to show interest in Dianabol and asked Ciba to describe a possible medical use for Dianabol, and the company does so by including items such as helping debilitated and bone-damaged patients. In 1970, the FDA recognized that Dianabol "may be effective" for the treatment of postmenopausal osteoporosis and pituitary dwarfism. These changes were reflected in prescribing guidelines in the 1970s, and Ciba was allowed to continue marketing and researching the drug. Eventually the company loses patent protection for the drug, and companies like Parr. Barr, Bolar, and Rugby entered the market with their own generic versions of drugs.
By the early 1980s, the FDA was removing the drug's "possibly effective" designation for treating dwarfism, and continued to insist that more data be obtained from the company. Sufficient clarification, however, is not received, and in 1983 Ciba officially removes Dianabol from sales in the United States. Perhaps the financial disinterest of the company played a role in this decision. In 1985, the FDA withdrew all generic Methandrostenolone from sales in the United States. In most Western countries, the drug is also leaving the pharmaceutical markets, due to the fact that in most sports the drug is recognized as doping. Methandrostenolone is still made today, but typically in countries with looser prescription drug control and regulation, and by companies that still target the black market for sports drugs.

Dosage forms

Methandrostenolone is widely available in the pharmaceutical and veterinary markets. Composition and dosage may vary by country and manufacturer.
Methandrostenolone was developed as an oral anabolic steroid containing 2.5 or 5 mg of the steroid per tablet (Dianabol). Modern brands usually contain 5 or 10 mg of the steroid per tablet. Methandrostenolone can also be found in injectable veterinary drugs. These are usually oil-based preparations containing 25 mg/ml of the steroid.
Structural characteristics
Methandrostenolone is a modified form of testosterone. It differs in: 1) the addition of methyl groups to carbon 17alpha, which protects the hormone when administered orally; 2) the introduction of a double bond between carbon atoms 1 and 2, which reduces its relative androgenicity.
The resulting steroid also has a much weaker relative affinity for androgen receptors than testosterone, but at the same time shows a much longer half-life and low affinity for serum proteins in comparison. These features (among others) allow Methandrostenolone to be considered a very potent anabolic steroid despite a weaker receptor binding affinity. Recent studies have further confirmed that the main function of the drug is interaction with cellular androgen receptors.

Side effects of Methandrostenolone

Side effects of Methandrostenolone (estrogenic)

Side effects of methandrostenolone (hepatotoxicity)

Methandrostenolone is a c17-alpha alkaline compound.
This protects the drug from deactivation in the liver, allowing a very high percentage of it to enter the bloodstream after ingestion. C17-alpha alkaline anabolic/androgenic steroids may be hepatotoxic. Long-term exposure or high dosages may cause liver damage. In rare cases, life-threatening dysfunction may develop. It is advisable to visit a doctor periodically during each cycle to monitor liver function and general health. The use of c17-alpha-alkylated steroids is usually limited to 6-8 weeks, which avoids the escalation of liver strains.
Studies have shown that taking methandrostenolone for several weeks at a dose of 10 mg per day or less causes minimal effects on the liver. At a dose of 15 mg per day, most patients begin to experience impaired liver function and increased retention of bromsulfalein (a marker of liver stress). Even when using 2.5 and 5 mg per day, increased levels of bromsulfalein have been reported in patients. Severe hepatic complications are quite rare given the intermittent nature of oral anabolic/androgenic steroid use, although they cannot be completely ruled out, especially with high doses and/or long-term use of Methandrostenolone.
When using any hepatotoxic anabolic / androgenic steroids, it is recommended to take liver detox supplements such as, or.

Side effects of methandrostenolone (cardiovascular)

Anabolic/androgenic steroids can adversely affect cholesterol levels. This includes trends towards lower HDL (good cholesterol) and higher LDL (bad cholesterol) levels, which can contribute to the risk of atherosclerosis. The degree of effect of anabolic/androgenic steroids on serum lipids depends on the dose, route of administration (oral or injection), type of steroid (or not) and the level of resistance to hepatic metabolism.
Methandrostenolone has a strong effect on cholesterol levels in the liver due to the fact that this substance is not, and due to its structure it can resist breakdown in the liver, in addition, the route of administration of the drug is also an important condition. Anabolic/androgenic steroids can negatively affect blood pressure and triglyceride levels, decrease endothelial relaxation, and promote left ventricular hypertrophy, which together potentially increase the risk of cardiovascular disease and myocardial infarction. To reduce the risk of cardiovascular deformities, it is recommended to perform vigorous exercise and minimize the intake of saturated fat, cholesterol and simple carbohydrates during the entire period of active use of AAS (anabolic / androgenic steroids). An additional intake of fish oil (4 g per day), natural cholesterol and antioxidants such as or products with comparable ingredients is also recommended.

Side effects of methandrostenolone (testosterone suppression)

All anabolic/androgenic steroids, when taken in doses sufficient to increase muscle mass, suppress the production of endogenous testosterone.
Methandrostenolone is no exception, and is known for its strong influence on the hypothalamic-pituitary-testicular axis. Clinical studies with 15 mg per day in endurance-training men for 8 weeks have shown an average reduction in plasma testosterone levels of approximately 69%. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months after taking the drug. Note that long-term hypogonadotropic hypogonadism may develop secondary to medical intervention.

Instructions for use Methandrostenolone (general)

Studies have shown that oral intake of anabolic steroids with food can reduce their bioavailability. This is caused by the fat-soluble nature of steroid hormones, which allows some drugs to dissolve undigested dietary fats, reducing their absorption from the gastrointestinal tract. For maximum benefit, the steroid should be taken on an empty stomach.

Instructions for use Methandrostenolone (for men)

The original Dianabol prescribing guidelines recommended a daily dose of 5mg administered on an intermittent basis for no more than 6 consecutive weeks.
Before resuming treatment, a break of 2 to 4 weeks is recommended. It is also used intermittently to improve physique or performance, with cycles typically lasting 6 to 8 weeks, interrupted by 6 to 8 weeks of rest. While a low dose of 5mg per day may be effective in improving performance, athletes typically take much larger doses. A daily dose of three to six 5mg tablets (15-30mg) is the most common, and usually gives very impressive results. Some use even higher dosages, but this practice usually results in a greater risk of side effects and is generally not recommended.
Dianabol pairs well with a variety of other steroids. For example, with a mild anabolic ®. Combined use can produce an exceptional increase in muscle mass and strength, with side effects not much worse than would be expected from Dianabol alone. For mass gain only, long-acting testosterone esters such as enanthate or cypionate can be used. However, given the high estrogenic/androgenic properties of this androgen, side effects may be more pronounced. The result will also be more pronounced, which usually pays for all the shortcomings of the drug. As discussed earlier, ancillary drugs may be added to reduce the side effects associated with these types of cycles.
The half-life of Dianabol is only about 3-5 hours. A once-daily dose will reflect differences in blood concentrations of the drug, rising and falling throughout the day. The user thus has the choice of splitting the dose throughout the day or taking it all at once. It is usually recommended to divide it and try to regulate the concentration of the substance in the blood. This, however, will be accompanied by a lower maximum concentration of the substance in the blood than when taking all the tablets at the same time. Both options work well, but anecdotal evidence supports the benefit of single daily doses for a better end result. With such a schedule, it seems logical to take the pills in the morning, which will promote significant androgen metabolism during the daytime, increasing nutrient absorption, especially during the critical hours after training.

Instructions for use Methandrostenolone (for women)

Being a moderately androgenic steroid, Dianabol is especially popular among men. When used by women, a strong risk of masculinization is possible. Some women still experiment with the drug, and often quite low doses (2.5-5 mg) of the steroid are quite effective for muscle growth. Studies have shown that most women after taking the drug notice the appearance of acne, which indicates its high androgenicity, at a dosage of already 10 mg per day. Children may notice the occurrence of virilizing effects already at a minimum dose of 2.5 mg per day.

Methandrostenolone's analogs

The number of dosage forms of Methandrostenolone on sale is frightening. Western medicine has completely done away with this steroid as it has been found to have no real therapeutic value. Its potential existence is justified as a doping support to improve performance, and nothing more.
Thus, it is impossible to find legal Dianabol from the USA, Canada or Western Europe.
The drug is produced exclusively in areas such as Asia, South America (limited), and Eastern Europe. Ignore drugs made in Italy or Spain, etc. They are illegal. Let's talk about the most popular legal brands on the black market.
Anabol tablets from the British Dispensary from Thailand are still very popular. Due to the large volume of counterfeit goods, the manufacturer has introduced three methods for detecting fakes. First, there is a holographic sticker attached to each pack of pills. Secondly, the company's logo - a snake - is printed on the tablets themselves. Finally, each package has a company logo. Please note that Anabol is in such high demand that some advanced counterfeiters duplicate the company hologram, pill coloring and packaging logo. Such fakes look quite plausible, but still somewhat different from the original.
Be sure to compare your product very carefully with photos of the original drug Anabol. Please note that the batch number and expiration date printed on the computer are present on the product packaging, as well as on the Anabol 10 preparation.
British Dispensary also makes a 10mg version of the drug called Anabol 10. The product has the same protection system as regular Anabol but is packaged in smaller yellow and white boxes. The tablets themselves are identical in shape to their 5mg version, and they also bear the company logo. The only difference between the two preparations is the color, which this time is not pink, but yellow.
In Russia, Akrikhin still produces generic Russian D-Bol (metahapoctehoroh), the company name in Cyrillic is Akpnxnh. The box is purple and contains 10 strips of 10 tablets each. This form of Dianabol has always been highly rated by users. Counterfeits of the drug are quite common, and most of them are rather poor copies of the original, often released in bottles instead of the proper packaging of foil and plastic. However, it cannot be said that the drug will necessarily be original if the packaging is correct, so carefully compare the product with the photos of the original. Please note that the manufacturer has started releasing a version of the product for the Ukrainian market. This drug can be identified by the company name Akpixih on the packaging. Some mistakenly assume that this is a fake, as the inscription looks more like a typo.
Naposim from Romania is still commercially available. The drug is supplied in white boxes containing 10 triangular-shaped tablets packed in foil and plastic. Note that the original Naposim foil strips are dated and batch numbered on both ends. Some counterfeiters in the past have overlooked this fact by placing the date and batch number on only one end. In addition, there is a slight bulge in the center of each Naposim tablet on the strip (soft strip of packaging). Product counterfeits in the past could be recognized by the smooth surface of the strip. Also, make sure that the triangular shape of the tablets is clear with sharp corners. One of the latest fakes looked more like the Star Trek emblem than a triangle. Also, note that some of the original strips have the word "metandienona" instead of "metandienonum". These are just variations of the export name of the product, and nothing more.
Also on sale is Danabol DS from Body Research/March Pharmaceutical Company from Thailand. The pills are made in the form of small blue hearts. This product is often counterfeited, so take care when buying to check its authenticity.
Methandon and Melic from Thailand, both legal drugs, come in packs of 1,000 tablets each. Both products are relatively rare on the black market today, although they are still in production. Their not so great abundance is a consequence of the much greater popularity and recognition of the drug Anabol, which dominates the Thai Dianabol market, despite ever-increasing competition. Both products contain pink 5-angle tablets like Anabol and are very similar in appearance, except for the packaging. The Methandon product (regular white tablets) is the most different from the rest, with the letters "ES" engraved on each tablet of the drug.
3 mg Anabolex tablets from the Dominican Republic are still
safe to buy. Please note that each tablet contains 1.5 mg of Periactin, used as an appetite stimulant. It is an antihistamine drug that can cause drowsiness. Make sure that the product is packaged in modern blue packaging, and not in white as before. Currently, such packaging has long disappeared from sale.
Metanabol from Poland is another legal brand, but make sure you get strips of 20 tablets.
Balkan Pharmaceuticals from Moldova produces Methandrostenolone under the name Danabol. The drug is supplied in foil and plastic strips of 20 tablets each. Both versions of the drug are currently being produced - 10 and 50 mg each. Forgeries are not known.
Jinan Pharmaceuticals in China produces a 10mg version of the drug under the export name Anahexia. The product is available in foil and plastic packs of 20 tablets per pack.

Bodybuilders around the world practice the use of approved drugs from a pharmacy in the course of their sports. In addition to vitamin and medicinal preparations, which are aimed at protecting and restoring the body's performance, athletes are interested in legal drugs that have anabolic effects.

The transfer of such funds includes very different drugs that are available for both athletes and ordinary citizens. The difference between pharmaceutical steroids and their chemical prototypes is that they are practically harmless to the human body. At the same time, their acceptable efficiency is noted, which makes it possible to increase up to 15 kg of muscle tissue weight in 3-4 months.

Many athletes regularly use legal pharmacy steroids in the competitive season, as they are not banned and are not detected in doping controls.

This drug blocks extragen receptors and stimulates the production of gonadolebyrin, which results in increased production of testosterone. As a result, in a person who regularly takes tamoxifen according to the instructions, there is a significant increase in muscle tissue, which contributes to a certain relief of the body.

Tamoxifen is taken at 20 mg, 1-2 times a day for 2 weeks. The drug acts, although slowly, but steadily.

In cases of taking this drug, side effects such as nausea, vomiting, decreased appetite, and venous thrombosis may develop.

The basis of this drug are natural hormone-like substances that some arthropods secrete. In addition, a similar substance is released from plants, such as safflower-like leuzea. Entering the human body, this substance causes protein synthesis, which leads to an increase in muscle volume. In addition, such a tool has an antioxidant and anti-catabolic effect, and also triggers fat burning mechanisms, while lowering cholesterol levels in the blood.

Side effects are possible only in cases of overdose, which causes allergic reactions, in the form of skin rashes, disorders of the digestive tract, and headaches.

Safinor

This is a combined preparation based on plant components that has a positive effect on the human body. Bodybuilders use it to increase muscle volume, which is associated with the activation of metabolic and neuroregulatory processes, as well as stimulation of repair processes and improvement of myocardial function.

The drug is taken 2-4 times a day, 1-2 tablets after meals. The course of admission can be about 5 weeks, with a minimum intake period of up to 7 days. Between each course of administration there should be a break of at least 3 weeks.

In the process of taking the drug, a negative effect is possible, which manifests itself in the form of skin itching, insomnia and irritability. In the event of such negative consequences, the dose of the drug should be reduced or completely discontinued.

Alvezin

It is also a combination drug based on herbal ingredients, which has a pronounced anabolic effect. At the same time, there is a drug obtained on the basis of artificial components.

The basis of the drug are vital amino acids, which contribute to an increase in the volume of muscle tissue, as a result of stimulation of protein synthesis and control of this process.

The drug is administered to the human body intramuscularly or intravenously, although the latter option is more preferable. The dose of this drug is limited to 400 ml divided into 2-3 days. It is possible to take the drug in courses of 5 weeks, with breaks of 3 weeks or less.

The drug has a metabolic effect, with the regulation of endogenous processes in the athlete's body. The tool is not very effective, but in bodybuilding it is used very actively. This is due to its stable action, which contributes to an increase in muscle volume and increased endurance.

It has a very positive effect on a person as a whole, improving the processes of protein metabolism, restoring liver function and stopping some changes in the myocardium.

Reception of potassium orotate is limited to a dose of 2 mg per day. The substance is taken 3-4 times a day 1 hour before meals. To show the effect of taking this drug, it should be taken up to 40 days. In case of a severe overdose, side effects may occur, in the form of dermatoses and malfunctions of the digestive tract.

Combined drug based on herbal ingredients, which has a hepatoprotective effect and anabolic effect. Bodybuilders use this drug because of its versatility. The drug Liv 52 helps to restore the activity of the liver due to its purification from harmful components that may remain in the liver after taking anabolic drugs of a “chemical” origin. In addition, the processes of protein metabolism are normalized, which contributes to an increase in the mass of muscle tissue.

The drug is taken half an hour before meals, 2-3 tablets 3 times a day. The course can last from 20 to 40 days, after which you can take a break of up to one month and repeat the drug.

Possible side effects of the drug, which are expressed: loss of appetite, disorders of the gastrointestinal tract, vomiting, nausea, etc.

It is a very important amino acid that is an integral part of proteins. It is involved in the process of growth of the human body in general. In addition, it is part of many substances that are so necessary for the normal functioning of the human body.

Methionine is actively involved in metabolism, which contributes to the active burning of fat. In addition, it is involved in the synthesis of creatine, adrenaline and other hormones, as well as in the rapid set of muscle mass.

The drug is taken 30 minutes before meals, 3-4 times a day, 1.5 grams. The course of taking the drug can be from 10 to 30 days, with a break of up to 2 weeks.

As for side effects, they may be vomiting and nausea. In this case, it is recommended to limit the intake of the drug or stop taking it altogether. In case of allergic reactions, it is advisable to consult a doctor for advice.

Methandrostenolone (lat. Methandrostenolone) is a drug that is an anabolic steroid. In clinical practice, the drug is used in the treatment of a number of diseases of the musculoskeletal system and other disorders. It is often used in combat sports, bodybuilding and other sports.

Some athletes believe that this drug is an effective recipe for a quick set of muscle mass, increased strength and endurance. Often, the Solo course with the use of this medication is involved in the training program. However, the consequences of the irrational use of this anabolic steroid can be fatal. The medication can cause severe harm to the human body and cause disability, so you should not take it without a doctor's prescription.

Release form composition and packaging

Auxiliary components of the drug depend on its dosage form. In tablet form, the excipients are starch, sugar, steric acid. Prepared water is present in the preparation in the form of a solution for injection.

Pills

Methandrostenolone tablets are packed in plastic blisters of 10 pcs. In a cardboard pack there may be 1, 2 or 10 blisters.

Ointment

This drug is not available in the form of an ointment.

injections

The solution for intramuscular injection is available in 100 ml glass containers, as well as in 5 ml ampoules. The solution is additionally packaged in cardboard packs, which contain instructions for use.

pharmachologic effect

The active substance Methandrostenolone has an activating effect on the genetic structure of the cell, which increases the production of RNA and DNA and leads to an increase in protein concentration. The ability of the drug to enhance the activity of enzymes in the tissue respiration chain, accelerate the synthesis of ATP and the rate of oxidative phosphorylation has been proven.

Anabolic action against the background of weak androgenic activity contributes to the suppression of catabolic processes.

Weakly expressed androgenic activity is expressed by the ability to stimulate the development of male secondary sexual characteristics. The drug has a pronounced anti-allergic effect, because. is able to increase the concentration of the C1 complement fraction of the inhibitor, as well as reduce the production of C2 and C4 complement. The anabolic effect of the drug leads to a stable gain in muscle mass and a gradual thinning of the fat layer. This aspect of the action of the drug contributes to the appearance of a negative nitrogen balance.

After taking the drug, the active substance is rapidly absorbed into the walls of the gastrointestinal tract. In this case, most of the dose is metabolized in the liver. The remaining amount of the active component of Methandrostenolone is 90% bound to plasma proteins. In the process of biotransformation, inactive metabolites appear. The effect lasts for about 14 hours. Metabolites are excreted by the kidneys.

Indications for the use of Methandrostenolone

Most often, this drug is used in the treatment of protein metabolism disorders and malnutrition arising from operations, severe injuries, burns, and radiation therapy. The indication for the use of Methandrostenolone is a progressive form of muscular dystrophy.

The drug is prescribed for diabetic angiopathy.

Methandrostenolone is indicated for glucocorticoid-induced myopathy. A limited medication can be used in the treatment of bone fusion disorders in fractures. The use of this anabolic is indicated for certain types of dwarfism and delayed puberty in boys. Limited medication can be used in the treatment of encephalopathy that occurs with alcoholic hepatitis.

The use of Methandrostenolone

Most people prefer to use the tablet form of this medication. This anabolic in most cases is taken orally. It is advisable to take the tablets after meals. The treatment regimen is selected individually for the patient. In most cases, adults in the treatment of existing disorders are prescribed this anabolic at a dose of 10 to 15 mg per day.

In severe cases, the dose may be increased to 30-50 mg per day.

The maintenance dose of the drug is 5-10 mg per day. The course of treatment with Methandrostenolone is from 30 to 60 days. After that, you need to take a 1-2 month break. The solo course used by athletes involves taking 30 mg per day, and the dose should be divided into 3 doses.

How to inject

It is necessary to prick the solution in a dose of 3 to 5 mg. The solution is used for intramuscular injections. The course of treatment with an injection solution should not exceed 14 days.

Side effect

The use of Methandrostenolone can cause great harm to the human body. Gynecomastia is often observed in men involved in spotting and abusing this medication. This side effect can occur when using both the solution and the tablets. The development of gynecomastia is associated with the conversion of the active substance into estrogen.

Against the background of long-term use of the drug, the liver is often affected.

Be sure to take tests and monitor blood counts for early detection of signs of disruption of the organ.

The most dangerous adverse reaction from taking an anabolic is hepatonecrosis. A symptom of this disorder is dark liquid feces, nausea, vomiting with blood impurities and deterioration in the general condition. Perhaps the appearance of hepatic purpura, hepatocellular carcinoma, cholestatic hepatitis and other disorders. In women, against the background of this medication, the appearance of secondary male sexual characteristics is possible.

Increased risk of hypercalcemia, bladder irritation and reduced sexual function. Often, when using Methandrostenolone, there are signs of disruption of the cardiovascular system, a pronounced increase in blood pressure, iron deficiency anemia and a tendency to bleed.

In older people, taking the medication increases the risk of developing representative gland hyperplasia.

While taking the medication, peripheral edema may occur.

Contraindications to the use of Methandrostenolone

The use of Methandrostenolone is contraindicated in the presence of hypersensitivity to the individual components of the drug. This medication should not be taken if you have a history of breast cancer, even if the disease is in remission.

You can not use this anabolic steroid in the presence of signs of prostate adenoma.

Contraindications for the use of Methandrostenolone are renal and hepatic insufficiency, nephrosis and hypercalcemia.

special instructions

With extreme caution, it is necessary to use the medication in the treatment of chronic heart failure. It is necessary to undergo a complete examination before taking the drug in the presence of a history of diabetes mellitus and coronary atherosclerosis. With extreme caution, the drug should be used in patients who have experienced myocardial infarction.

Use during pregnancy and lactation

This anabolic steroid should not be used during pregnancy and while breastfeeding a child.

How to take with violations of kidney function

In the presence of acute or chronic kidney disease, it is better to stop using Methandrostenolone.

Use in children

Children are prescribed the drug strictly according to indications. The daily dose is divided into 1 or 2 doses.

The dosage is selected individually. For children under 2 years of age, the drug is prescribed at a dose of 0.05-0.1 mg. For children from 2-5 years old, the drug is prescribed at 1-2 mg per 1 kg of weight. In the treatment of children from 6 to 14 years old, the drug is used at 3-5 mg per 1 kg of weight.

Overdose

In case of an overdose, an increase in the size of the liver is possible.

In this case, it is required to cancel the drug, perform gastric lavage and symptomatic treatment.

drug interaction

While taking Methandrostenolone, dosage adjustment of antiplatelet agents, anticoagulants and hypoglycemic agents is necessary, because. this anabolic increases the effect of these medications.

Tablets white color, ploskotsilindrichesky, with a facet

Compound

1 tablet contains methandienone 5 mg

Excipients: sugar, potato starch, stearic acid.

Release form

Pills.

Pharmacological group

Anabolic agents for systemic use. Anabolic steroid. Androstano derivatives.

ATC code A14 AA 03.

Pharmacological properties

Pharmacological. Methandienone is a synthetic steroid with pronounced anabolic and weak androgenic properties. Stimulates protein synthesis in the body, causes retention of nitrogen, calcium, sodium, potassium, sulfur, chlorides and phosphorus, which leads to an increase in muscle mass and accelerated bone growth, water retention in the body.

Pharmacokinetics. Rapidly and completely absorbed from the gastrointestinal tract, low bioavailability due to the presence of the effect of the first pass through the liver. In the blood, 90% binds to specific carrier globulins. Undergoes final biotransformation in the liver with the formation of inactive metabolites. Excreted by the kidneys. Duration of action - up to 14 hours.

Indications

• Cachexia of various origins;
• protein metabolism disorders after severe injuries, infectious diseases, burns, surgical operations, radiation therapy
• osteoporosis of various origins; progressive muscular dystrophy;
• prevention of myopathy and osteoporosis during the treatment of corticosteroids;
• delayed callus formation after fractures.

In pediatric practice, the drug is indicated for growth retardation, Shereshevsky-Turner syndrome, anorexia and malnutrition.

Dosage and administration

Methandrostenolone is prescribed orally before meals. The initial dose is 10-15 mg/day, in some cases the dose may be increased to 30 mg/day. Maintenance dose - 5 - 10 mg / day. The maximum single dose is 10 mg, the maximum daily dose is 50 mg. The course of treatment is 4 - 8 weeks interval between courses - 1 - 2 months.

For children from 6 to 14 years old, the drug is prescribed at a dose of 2.5 mg (half a tablet) - 5 mg / day daily or every other day. The course of treatment should not exceed 4 weeks intervals between courses - 6 - 8 weeks.

Side effect

• Dyspeptic disorders: nausea, vomiting, diarrhea, abdominal pain
• hepatocellular carcinoma, jaundice;
• allergic reactions;
• increased bleeding;
• depression, sleep disturbance;
• muscle cramps
• adenoma and adenocarcinoma of the prostate;
• seals of the mammary gland;
• gynecomastia in men;
• symptoms of virilization in women (hirsutism, baldness, irreversible decrease in the timbre of the voice, menstrual irregularities, depression of ovarian function, enlargement of the clitoris)
• polyuria and increased urination
• edema
• leukemoid reaction;
• premature closure of growth zones in children and adolescents.

Contraindications

• Hypersensitivity to the drug
• pregnancy, breastfeeding period
• prostate cancer or adenoma
• acute or chronic prostatitis
• breast cancer in men;
• severe liver damage, liver failure
• ischemic heart disease, myocardial infarction, heart failure
• diabetes
• hypercalcemia.

Overdose.

Symptoms: increased side effects Treatment is symptomatic.

If signs of virilization appear, the drug should be discontinued.

Application features.

To achieve the optimal effect, simultaneously with the use of methandrostenolone, the patient should receive an adequate amount of proteins, fats, carbohydrates, vitamins and minerals with food.

Methandrostenolone (methane): general information about this drug and instructions for its use will be given here. Both the positive effect and the possible risks from its use will be considered. Let's talk about similar tools, as well as where and how to buy this anabolic.

About Methandrostenolone

The drug methandrostenolone (in the slang of bodybuilders - just "methane") is one of the most popular (and maybe the most) anabolic steroids. In fact, it is a synthetic and modified testosterone hormone. It was originally released in the US in 1958 under the name Dianobol. It is a powerful doping and promotes an active increase in the muscle mass of athletes in a very short period of time. It is used both in sports medicine and in secular medicine for the treatment of a number of diseases, such as:

• Fractures.
• Burns.
• Renal failure.
• muscle dystrophy.
• drug myopathy.
• Violation of protein metabolism. Protein deficiency.
• Infectious diseases leading to protein loss.
• With sprains and injuries, to accelerate tissue repair.
• Growth retardation, as well as physical and sexual development. Particularly in children and adolescents.

It is available both in tablets and as a solution for injection. Most effective for those who have started using it recently. In "hardened" bodybuilders, with prolonged use, the effectiveness decreases over time. Methandrostenolone in a pharmacy is sold only by prescription, but it will not be difficult to purchase the drug in other places, but more on that later.

The effect for bodybuilders from the use of "Methane"

Among jocks-“chemists” (those who like to stuff themselves with all sorts of chemistry for a greater effect from exercising in the gym), where this anabolic is very popular, there are rarely doubts about whether methane is good for muscles. It is not surprising, because with its help, in a fairly short period of time, you can turn from a stunted and nondescript goner into an inflated and brutal athlete.

Here are its most effective qualities:

• Active and rapid muscle building.
• Increase in strength indicators.
• Acceleration of protein synthesis.
• Strengthening bones.
• Increased appetite.
• Slowing down the process of protein breakdown (anti-catabolic effect).

As you can see, the effect of methandrostenolone is very noticeable for bodybuilders, so it is difficult for many to resist the temptation to start using it. Whether this is good or bad is a personal matter for each athlete. After all, indeed, this substance gives a number of advantages over those who do not like "chemistry" and prefer chicken breast to some kind of chemicals. But methane also has side effects, which will be discussed now.

side effects of methane

Like any other medicine, methane tablets (or injections) have their own side effects:

• Increased blood pressure due to water retention in the body.
• Tachycardia.
• Disorder of the stomach and intestines.
• The production of the female sex hormone estrogen. As a result - the appearance of secondary sexual characteristics.
• Iron deficiency and related anemia.
• Eruptions on the skin. Acne and pimples.
• Excessive concentration of calcium in the blood.

And this, alas, is not all the side effects of this drug.

There is also a myth that almost all “jocks” who are on steroids supposedly don’t have something there (well, you understand what it is). However, the athletes themselves refute this myth and believe that this is complete nonsense. I tend to agree with them, because many athletes who “sit” on anabolics and use methane for muscle growth have couples, are married and somehow even manage to reproduce. So believe in this myth or not - think for yourself. But if you still decide that you can’t do without steroids, then in order to avoid such a scenario and minimize the harm from the “side effect”, it would not hurt you to find out what the instructions for using methane look like, read it carefully and read it exactly follow.

Instructions for use solo and dosage

The optimal daily dose of the drug is 20-30 mg. It is best to take methane twice a day, morning and evening, from 6 to 9 am, and 18-21 pm. It is better to take after a meal. Frequent and long-term use is highly discouraged, as the body becomes addicted to the active substance and its effectiveness decreases over time, or even completely disappears.

Therefore, methandrostenolone should be taken with regular pauses. The duration of one course should not exceed one and a half months. Approximately the same should be the pause between courses of admission.

It is also worth noting such an application scheme as a "pyramid". According to this scheme, the dose of the drug is first gradually increased, and then just as smoothly lowered. But there is an opinion that such a scheme is extremely inefficient and does not justify itself. It is better to use methandrostenolone, or its analogues, twice a day, 10 mg per dose, and do not change the dosage throughout the course.

An important point: some bodybuilders, for the sake of greater efficiency, sometimes significantly overestimate the dose of the drug. Doing this is strongly discouraged! Otherwise, at least the myth of sexual dysfunction may well become a reality for you! And in addition, such neoplasms as horns, hooves and a pig's penny may appear. Jokes are jokes, but you shouldn't expect anything good from this. Do not become enemies of your body, for the sake of extra pounds of meat on the body! It is better to read real reviews about methane and other "chemistry".

Analogues and substitutes

Each medication has its own analogues and substitutes. Methane is no exception. Here is a list of the most famous analogues:

• Primobol.
• Strombafort (Stanozolol).
• Danabol, Methandienone, Dianabol, Nerobol are other names for the same good old methane.

With the help of methane, it is possible to increase, on average, 9-10 kg of "meat" for a course of 6 weeks. However, you can also lose it later very quickly, if you do not take into account and neutralize the so-called. rollback phenomenon, which will be discussed in more detail below.

Rollback phenomenon and combined intake of methane with other drugs

A separate line is worth mentioning about such a phenomenon as. It consists in the fact that after the end of the next course of methane use (however, like any other steroids), the muscle mass gained by the athlete during this time begins to decrease rapidly, practically nullifying all the positive effect of taking the drug.

It is impossible to completely get rid of such an effect - it will overtake you anyway, but it is quite possible to minimize it. To do this, you need to correctly select the course of use, and the combined use of steroids with other drugs. Here are some important guidelines and techniques for mitigating recoil:

• The so-called "bridge" between courses of methandienone. Its essence lies in the fact that during the break between taking "meta" your body still receives a certain dose of testosterone. To do this, you can use other steroids made from testosterone esters. Perfect drugs such as: Omnadren; Testosterone cypionate; Testosterone enanthate; Sustanon.
• Since such an important male organ as the testicles is responsible for the production of testosterone, the course should be selected with an emphasis on restoring their functionality, which will noticeably decrease with a sharp cessation of anabolic steroids. As a rule, in such cases, the use of a hormonal preparation of gonadotropin is recommended.
• A significant decrease in the intensity of training will be required. No excessive loads. During this period, training will work against you and your muscles in particular. Of course, you shouldn’t completely abandon them either, so as not to lose shape and tone, but you should train in an energy-saving mode.
• You should saturate your diet with protein foods, but this is not enough. You will have to use protein supplements, either.
• During the course, it will also not be superfluous to use the combined intake of methane, in conjunction with other steroids, for example, with stanozolol (Winstron) or the usual supplement -. If you correctly compose a combined course, then the rollback will not be so noticeable.

Post cycle therapy

During pauses, after taking anabolic steroids, to restore the hormonal system and eliminate negative consequences, it is recommended to carry out post-cycle therapy. Before that, you need to visit a doctor so that he can prescribe all the necessary tests for hormones. Based on these analyzes, you will be individually selected a course of PCT.

Most often, athletes are prescribed medications such as:

• Gonadotropin.
• Proviron.
• Tamoxifen.
• Clomiphene.

In general, anabolics for hormonal balancing. Methane has a bad effect on the liver, so it is recommended to help it by drinking hepatoprotectors - Essentiale or Essliver Forte. But only a doctor should prescribe this to you!

Where to buy methane and at what price

As mentioned above, buying steroids in a pharmacy, if you are a healthy person, is almost impossible. Therefore, most often athletes look for such products on specialized sites, visit forums, and also learn through familiar places where methandrostenolone and other anabolics are sold. So it's already a black market.

In many countries, anabolics are now considered far from harmless drugs. Their production and sale are considered illegal in the Russian Federation and are equated with drugs. But, if you wish, you can still buy methandrostenolone. Pricing may vary by region and by vendor. The cost on the "black market", at the moment, ranges from 1000 to 1500 rubles for 100 tablets of 5 mg.

The most popular methane producers

The most popular among athletes are the following trade brands that produce methandienone and its analogues:

• LA Pharma s.r.l. -Italy.
• "British Dispensary" - Founded in the UK, subsequently moved to Thailand.
• "Body Research" - Thailand.
• ZPHC Zhengzhou Pharmaceutical - China.
• Global Anabolic - Hong Kong.
• ERGO MRC - Belgium.
• "British Dragon" -Thailand.
• Axio Labs is a subsidiary of British Dragon.
• Kubera Pharma - India.
• "Radjay" - India.