Utrozhestan what hormone. Utrozhestan: instructions for use and what it is for, analogues, reviews

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Violations hormonal background often lead to miscarriages. Their main cause is a lack of progesterone. This sex hormone reduces contractility smooth muscle uterus and promotes the transition of the endometrium to the secretory stage. Gynecologists ask women to take Utrozhestan in the form of capsules or suppositories in accordance with the instructions during pregnancy if a lack of progesterone is detected.

What is Utrozhestan

This drug is vegetable analogue progesterone. Utrozhestan is taken during pregnancy to prevent miscarriage. The hormone progesterone, which is part of the drug, is micronized, i.e. it is completely absorbed by the body and practically does not cause side effects. Doses of Utrozhestan are calculated by the doctor individually for each woman.

Composition and forms of release

The drug is available in capsules. They are used as tablets and as vaginal suppositories. Main active substance hormonal drug is progesterone. One capsule, depending on the concentration, may contain 100/200 mg of the hormone corpus luteum. As excipients involved lecithin and sunflower oil. Full squad one capsule medicinal product shown in the table below.

pharmachologic effect

The drug is progestogen (containing the corpus luteum hormone). Assign Utrozhestan with the threat of miscarriage in the early stages and for the onset of pregnancy. The main active ingredient of the drug is natural progesterone, obtained from plant extracts. It quickly binds to the cells of the target organ, stimulates the synthesis of pH by activating DNA.

Indications for use

The tool is an analogue of female progesterone, so it is prescribed for deficiency of this hormone. Utrozhestan capsules are taken not only for the correction of disorders reproductive system. When forming a cycle for correction premenstrual syndrome the drug is prescribed to adolescents. Indications for oral administration medicinal product:

treatment of infertility caused by luteal insufficiency;
violations menstrual cycle due to problems with ovulation or anovulation;
fibrocystic mastopathy;
premenopause;
hormonal disorders caused by an excess of estrogen (fibroids, uterine bleeding, cysts);
painful periods;
substitution hormone therapy.

Utrozhestan is administered vaginally to maintain pregnancy, maintain the luteal phase during in vitro fertilization(IVF), to compensate for the lack of progesterone in premature menopause. With caution, a remedy is prescribed if a woman is diagnosed with chronic renal failure, bronchial asthma, liver disease, diabetes mellitus, arterial hypertension, diseases of cardio-vascular system.

How Utrozhestan affects pregnancy

The drug helps the fertilized egg to attach to the wall of the uterus and supports its development into an embryo. Pregnancy in Utrozhestan is easier, because. it compensates for the lack of progesterone, reduces the tone of the uterus. The drug does not affect the child. average price the drug is 420 rubles. It can only be purchased with a doctor's prescription.

When planning

If a woman has problems conceiving or has had a miscarriage, the gynecologist may prescribe progesterone therapy. When developing individual scheme medication taking into account the results of ultrasound and biochemical analysis blood. Normal progesterone before ovulation should be at least 7 nmol / l. When less of the hormone is produced by the ovaries, a woman cannot become pregnant. As a standard, the doctor prescribes 200-300 mg of the drug orally 2 times a day.

In the early stages

In the first trimester, the capsules are administered vaginally. Utrozhestan in early pregnancy reduces the tone of the uterus, helps to relax the nervous system. On the part of the body, a slight reaction in the form of nausea and dizziness can be observed. There is no single recommendation for all women. A possible daily dosage of the drug is 300-600 mg. Capsules do not cause any hormonal disorders in the fetus.

At a later date

The drug is prescribed in the second trimester of pregnancy, if the underdevelopment of the placenta has been diagnosed. During this period, the drug is also indicated for women after IVF. If the patient had a history of problems with bearing a child or a miscarriage, then in order to prevent spontaneous abortion, artificial progesterone is prescribed. Daily dosage funds should not exceed 600 mg.

Instructions for use Utrozhestan during pregnancy

The drug is taken orally or administered vaginally. The standard dosage is 200 mg. Take the capsules twice a day. Utrozhestan for pregnant women is not dangerous, but may cause some side effects (headache, bloating, itching, acne). Often, after using the medication, drowsiness and absent-mindedness appear, so doctors recommend refraining from driving a motor vehicle.

Tablets

Oral intake of capsules reduces the risk of spontaneous abortion. Tablets are prescribed after conception at 10-12 weeks of pregnancy. With the threat of miscarriage, oral capsules can be combined with vaginal. General dosage medication should not exceed 600 mg. Tablets are washed down with a glass clean water. Contact of progesterone with the gastrointestinal tract is contraindicated when chronic diseases liver, gastritis and other problems with the digestive system.

Candles

With a tendency to thrombosis and thrombophlebitis, for the prevention of miscarriage, the agent is prescribed intravaginally, but at the same time the patient's condition is monitored. If vaginal discharge is observed, the remedy is canceled. A gynecologist may prescribe progesterone suppositories if a woman has problems conceiving. It is necessary to enter them before going to bed.

Pharmacological enterprises produce capsules for vaginal administration of 100 and 200 mg. The agent is quickly absorbed into the bloodstream without affecting the liver. This form drugs go well with vitamin complexes for pregnant women and sedatives. After conception, the drug is canceled in the second trimester, reducing the dosage by 50-100 mg per week.

Cancellation of Utrozhestan during pregnancy - scheme

The dose is reduced every week by 100 mg. A woman must constantly monitor that there is no bleeding from the genital tract. Some patients are advised to reduce the dose by 50 mg every 3 days. The gynecologist describes the drug withdrawal scheme in detail. You should not deviate from it, because. with a sharp change in the amount of progesterone in the body, an abortion can occur.

Utrogestan analogues during pregnancy

The drug can be freely bought in pharmacies in Moscow and St. Petersburg for 420 rubles. In the regions, it is easier to find synthetic analogues of progesterone. Their cost is lower, and the efficiency is at the same level. Among analogues of the drug pharmacological action Closest to Duphaston. The active substance in this medicine is dydrogesterone. It is well absorbed in gastrointestinal tract. The average price of Duphaston is 560 rubles. In pharmacies you can find the following analogues of Utrozhestan:

Crinon;
Iprozhin;
Progestogel 1%;
Progesterone;
Prajisan.

Many women dream of having children, but not everyone succeeds. Often pregnancy does not occur or it happens, but a miscarriage occurs due to not enough in the body of progesterone. Produced by the ovaries in sufficient quantities, it helps to preserve the embryo and contributes to its normal development. With a lack of progesterone, doctors prescribe the drug "Utrozhestan", placing high hopes on it. In this case, the woman bears and gives birth to a child without any problems. As evidenced by numerous reviews, "Utrozhestan" during pregnancy is very effective.

Purpose and form of release

"Utrozhestan" is drug, consisting of natural micronized progesterone hormone. Most often, doctors prescribe it during pregnancy so that there is no miscarriage or premature birth. Also use "Utrozhestan" when the feedback on his admission during this period is only positive. In addition, with the help of it, diseases that occur against the background of a lack of progesterone are treated. This is fibrocystic mastopathy, menstrual irregularities. The drug is prescribed to women during menopause to eliminate the climatic syndrome.

"Utrozhestan" is produced in capsules that can be used orally or topically, like vaginal suppositories (which is why capsules are sometimes called suppositories, in fact there is only one form of release of the drug). They contain 100 and 200 mg of the active substance, which is micronized natural progesterone, which is well absorbed into the bloodstream. Excipients- this is peanut butter, gelatin, soy lecithin, titanium dioxide, glycerol. Candles "Utrozhestan" are very effective during pregnancy. Reviews of patients and doctors testify to this.

Indications for use

The use of the drug leads to the following positive aspects:

normal endometrium begins to form;
increases the concentration of insulin;
glycogen in the liver begins to accumulate intensively;
the excitability and contractility of the muscles of the uterus decreases and fallopian tubes;
the uterine mucosa enters the secretory phase.

"Utrozhestan" is used to treat diseases that have arisen against the background of an insufficient amount of progesterone in the body.

Oral administration is indicated in the following cases:

in complex therapy infertility caused by insufficiency;
if the menstrual cycle is disturbed;
to relieve symptoms during menopause;
removal of tension syndrome before the onset of menstruation;
for the complex treatment of fibrocystic mastopathy.

with a lack of progesterone;
to maintain the luteal phase;
as a prevention of the formation of uterine fibroids and endometriosis;
so that a miscarriage does not occur;
with infertility associated with a lack of lutein;
as a result of premature menopause.

Mode of application

At oral intake if a woman is planning a pregnancy, "Utrozhestan" is taken 2 times a day. In some cases, the doctor may increase the dose to 400 mg per day. For the treatment of fibrocystic mastopathy, as well as premenstrual syndrome, the dosage is 400 mg per day, the duration of treatment is 10 days.

With intravaginal use, if a woman is completely absent of progesterone, the drug is used for at least 3 months. The dosage is selected by the doctor in each individual case. If it exists in the first and second trimester of pregnancy, "Utrozhestan" is used twice a day, injected deep into the vagina.

special instructions

Do not use the drug as a means of contraception, as it does not have contraceptive effect. When applied in the first half of the menstrual cycle (before ovulation), a shortening of the cycle or bleeding may occur.

If arose uterine bleeding, then "Utrozhestan" is not recommended to be taken until the cause of such a pathology is clarified.

When the following symptoms the drug should be stopped as soon as possible:

double vision;
damage to the vessels of the retina;
unbearable headache;
vision loss;
thrombosis of veins and arteries;
migraine.

In this case, you should immediately consult a doctor.

"Utrozhestan" during pregnancy

The reviews of most women taking this drug during pregnancy are positive, as it contributes to the successful bearing of a child. It is allowed to be taken in the first and second trimester, up to the 27th week. After this period, it should be used with caution and only if there is evidence for this.

The drug helps prevent miscarriage and prevents premature birth, especially if a woman is diagnosed with complete ovarian dysfunction or a lack of progesterone. Moreover, there is a high probability that pregnancy will occur after Utrozhestan. Reviews eloquently testify to this.

Indications for taking the drug if pregnancy is only planned

In what cases should I take "Utrozhestan" when planning a pregnancy? The doctors' comments indicate that the indication for taking the drug is It is characterized by a low body temperature in the period following ovulation, and various violations menstrual cycle. Such a violation in the work of the body occurs quite often. That is why, in order to prevent a miscarriage, Utrozhestan candles are prescribed during pregnancy. Reviews of women indicate that they are quite effective.

Also an indication for taking artificial progesterone during pregnancy planning is the prevention of endometriosis. In this state of the body, a very strong growth of the uterine mucosa occurs or it begins to penetrate into the deeper layers of the tissue. Most often, endometriosis occurs in women aged 30 to 45 years with a short menstrual cycle, who have impaired metabolism, whose estrogen levels are significantly elevated, and who constantly use intrauterine contraceptives.

Because of this disease, pregnancy can be expected for a very long time, because with endometriosis, cysts begin to form on the wall of the uterus, in the ovaries, inside fallopian tubes. All this leads to a decrease in the patency of the tubes, the work of the ovaries is disrupted, and the implantation of the embryo into the uterine wall is significantly more difficult. That is why doctors prescribe "Utrozhestan" when planning a pregnancy. Feedback from women on this issue is also positive.

The drug normalizes the menstrual cycle, creates right conditions to fertilized egg fixed in the uterus, and in case of a threatened miscarriage, it helps to maintain the pregnancy.

Contraindications and side effects of the drug during planning

A woman who dreams of becoming pregnant should know that although this drug helps to fulfill the dream of having a child, its use is possible only as directed by a doctor. "Utrozhestan" may have the following contraindications:

thrombophlebitis;
liver disease;
malignant tumors;
phlebeurysm.

Very rarely, side effects occur when using the drug "Utrozhestan" (candles). Reviews when planning pregnancy about this drug indicate that drowsiness and dizziness may occur, which are of a short duration. But you should be careful while driving, because a small effect on the central nervous system adversely affects the reaction rate when driving.

Indications for taking the drug during pregnancy

As numerous reviews show, "Utrozhestan" during pregnancy is of great benefit. At healthy women the progesterone produced begins to build up the endometrium, while the uterine mucosa thickens and enriches blood vessels and the embryo receives sufficient oxygen and nutrients.

For women with progesterone deficiency, the drug is prescribed to prevent miscarriage. In addition, it is prescribed if it exists due to an increase in the tone of the uterus. The drug helps to reduce it, allowing a woman to carry a child normally.

Contraindications of the drug during pregnancy

"Utrozhestan" can not be taken in the following cases:

vaginal bleeding of unknown origin;
porphyria;
intolerance or allergic reactions to the components of the drug;
incomplete miscarriage;
tumors of the genital organs or mammary glands, which are malignant in nature;
thromboembolism;
tendency to develop blood clots;
severe liver disease.

These contraindications are considered absolute, that is, it is strictly forbidden to take the drug if they are present.

The drug Utrozhestan (candles or tablets) contains a progestogenic sex hormone in its composition. You need a drug in order to become pregnant, as well as during pregnancy.

active operating element this medication- These are granulosa cells of the ovarian follicle that produce endogenous steroid. When it enters the body of a woman, it contributes to the normalization of secretory transformations in the uterine cavity.

Enhances the transformation of the mucosal layer, which promotes the formation and process of formation and growth of the embryo. During the period of gestation, it reduces the tone of the uterus, causes the end sections of the milk ducts in the chest to transform.

In the process of recovery normal level biologically active form testosterone, which blocks the production of pituitary gonadotropins, leads to a decrease in androgen levels. Antimineralocorticoid action is manifested by increased urine output.

Compound

The composition of the drug Utrozhestan includes:

Release form and cost

The drug Utrozhestan is a candle and a pill at the same time. The drug is made in such a way that it can be used, if necessary, both vaginally and orally.

Produced in the form of dosed medicinal tablets round shape. They have a sparkling egg-colored surface. In the middle of the drug - a homogeneous ointment-like mixture of milky color. Tablet or candle: 0.1 g - 30 pcs. in a plate, 0.2 g each - 14 pcs. in the plate. The plate is placed in a container made of thick paper.

The cost of the drug Utrozhestan varies from 400 rubles. up to 500 rubles for 1 pack.

Taking the drug if pregnancy is only planned

Utrozhestan (during pregnancy at the planning stage) is used both orally and vaginally.

1. Orally:

when it is impossible to conceive;
in violation of the luteal phase;
in the absence of ovulation;
in violation of the release of the egg from the ovary into the fallopian tubes.

2. Vaginally:

Utrozhestan (during pregnancy or when planning it) has limitations and unwanted manifestations. The drug can only be prescribed by a doctor after an examination and determine whether there are contraindications or not.

Restrictions:

chronic or acute stage varicose disease lower limbs;
thrombosis of the lower extremities;
diseases of the biliary tract;
hepatitis;
malignant neoplasms;
heart disease;
encephalopathy;
chronic inflammatory diseases respiratory system;
at chronic insufficiency pancreatic hormone.

Undesirable manifestations:

at oral administration passivity, lethargy, drowsiness, unsteadiness of gait;
decrease in the severity of the reaction;
vegetative-vascular dystonia;
astheno-neurotic syndrome.

Features of use during childbearing

During pregnancy, it is necessary to take the drug in the following situations:

the threat of spontaneous abortion;
how prophylactic with the threat of abortion;
inflammatory manifestations of the uterine cavity;
inflammation of the ovaries and fallopian tubes;
to relieve uterine tone.

Utrozhestan during pregnancy has limitations in use.

These manifestations include:

Effect on the body

The drug Utrozhestan has different action, depending on the period of admission: before becoming pregnant, or during childbearing.

1. When planning a pregnancy:

2. Mechanism of action at gestational age up to 20 weeks:

the drug must be applied vaginally, which relaxes the walls of the uterus;
taking Utrozhestan has a positive effect on nervous system due to hormonal changes;
reduces the threat of abortion;
for safety net in case of spontaneous abortions in anamnesis;
history of infertility;
with nervous excitability;
reduces the body's response to the manifestation of toxicosis;
used for bloody discharge from the vagina, due to the threat of abortion - relieves spasm;
relieves pain in the lower abdomen;
relaxes the hardened uterus, as a result of the threat of termination of pregnancy;
with fetal hypoxia;
with the threat of abortion;
removes inflammatory processes in the genitourinary system;
restores the level of progesterone, which affects the termination of pregnancy;
for supporting prenatal development fetus until the placenta is formed.

3. Utrozhestan on later dates pregnancy:

Instructions for using candles

Utrozhestan (during pregnancy or when planning it) must be taken in the form of round tablets, the same as oral ones, but with higher dosage- 0.2 g.

When planning pregnancy, suppositories should be used in the following pathological conditions:

hormone replacement therapy in the absence of one of the two paired female genital organs - the ovary;
in case of violation hormonal function paired organ;
before IVF fertilization;
in the absence of ovulation;
at irregular ovulation, due to disruption of the endocrine glands;
how preventive actions spontaneous abortions due to endogenous insufficiency;
threats of spontaneous abortions in history;
treatment of uterine fibroids when planning pregnancy;
treatment early menopause when planning a pregnancy;
how prophylactic method growing connective tissue uterus when planning a pregnancy.

Only a doctor deals with the treatment of pathological processes.

Dosages:

During pregnancy, Utrozhestan suppositories must be used in the following pathological conditions:

with insufficient production of endogenous steroid;
with hypoxia of the uterine layer;
in violation of the blood circulation of the uterine cavity;
with spontaneous bleeding;
at premature detachment placenta;
at increased tone the muscular layer of the uterus;
to increase the number of days of pregnancy - so that childbirth occurs on time;
warning early term childbirth or miscarriage, which is already in the anamnesis;
to improve blood circulation in the vessels of the muscular layer of the uterus and the child's place;
for the prevention of fetal hypoxia;
decrease contractile activity uterine cavity;
prevent untimely labor activity.

If a woman has a history of hormonal disorders, then vaginal form the drug Utrozhestan should be started immediately, from the moment of pregnancy.

Dosages:

The use of tablets

Utrozhestan for oral use is available in a dose of 0.1 g - 1 pc. Tablets must be taken when planning, as well as during pregnancy.

When planning pregnancy, Utrozhestan tablets should be used in the following pathological conditions:

habitual spontaneous abortions;
endogenous steroid infertility;
problems with the uterine cavity;
spontaneous abortions due to hormonal imbalance;
pathological (genetic) insufficiency of endogenous steroid hormone;
lack of one paired sexual female organ ovary;

Therapy should be prescribed only by the attending physician.

Application:

Utrozhestan tablets when planning pregnancy should be taken from 0.2 g to 0.3 g per day - in the morning, afternoon and evening, 1 pc. at the same time intervals. Do not chew. Need to drink enough liquids. The duration of therapy with Utrozhestan tablets lasts from 10 to 14 days, you need to use the drug from the 14th day to the 26th day of menstruation. With the onset of pregnancy, the use of the drug Utrozhestan should be continued up to 14 weeks, and sometimes up to 28 weeks of pregnancy. The appointment and cancellation of the drug Utrozhestan occurs under the strict supervision of a physician.

During pregnancy, the tablet drug Utrozhestan must be started to be used in pathological conditions:

Treatment with Utrozhestan tablets should be carried out under the strict supervision of a physician.

Application:

the usual amount of the drug - 0.2 g - 0.3 g per day - in the morning and in the evening, at regular intervals;
IVF - Utrozhestan tablets must be taken before artificial insemination. It is necessary to take from 0.2 g to 0.6 g of the drug per day - 3 times in complex therapy with injections pituitary hormones. The course of therapy with Utrozhestan tablets is 28 weeks from the moment of fertilization;
with the threat of spontaneous abortion, tablets are prescribed from 0.2 g to 0.4 g per day, can be taken in 2-4 doses at regular intervals;
in the prevention of spontaneous abortions in history - 0.2 g in the morning and evening. Treatment should be carried out before the 14th week of pregnancy if the pregnancy proceeds safely.

Correct use of the drug hormonal agent Utrozhestan during gestation abnormal pregnancy requires strict adherence to medical recommendations.

Tablets Utrozhestan:

preventive measures for recurrent spontaneous abortions: it is necessary to use the drug within 14 weeks of pregnancy. In case no positive result in treatment, the duration of therapy should be extended;
in case of bleeding, it is necessary to use Utrozhestan tablets up to 24-28 weeks of pregnancy.

The tablet form of the drug Utrozhestan, in case of urgent need, can be used until the 38th week of pregnancy.

Candles Utrozhestan usually need to be prescribed up to 28 weeks. In case of urgent need, the use of the vaginal medication Utrozhestan should be extended until the 33-35th week of pregnancy.

Drug withdrawal scheme

If a woman used the drug Utrozhestan for 14 to 28 weeks of pregnancy, you need to smoothly and gradually reduce the dose of the drug.

For example: a pregnant woman consumes 0.4 g of the hormonal drug Utrozhestan per day, then in the next week the dose must be reduced by ¼. And so it is necessary to do every subsequent 7 days until the drug is completely discontinued.

Usually, doctors advise starting to reduce the dose of Utrozhestan no later than the 30th week of pregnancy, or even earlier. When the drug is discontinued, it usually appears bloody issues, which should not be considered as pathological process- The discharge will pass in a couple of days on its own.

The drug Utrozhestan when planning pregnancy and its further bearing, as well as a drug for hormonal pathologies in women - has established itself as an effective remedy.

Article formatting: Vladimir the Great

Lack of progesterone, the main pregnancy hormone, leads the list of causes of miscarriages in the first trimester. The specificity of the drug Utrozhestan lies in the fact that it contains a synthetic version of this hormone, which, unlike endogenous progesterone, is able to be absorbed by the intestines. At the same time, the structure of the analogue molecule is absolutely identical to the structure of the molecules of the natural hormone.

Indications for taking Utrozhestan

An important condition for the development of pregnancy is sufficient production of progesterone, which begins from the moment of conception. A constant level of the hormone is maintained first by the corpus luteum of the ovaries, then progesterone is produced by the placenta. It is thanks to this that the proper development of the fetus is ensured, and uterine contractions are prevented. In addition, the action of progesterone is due to the timely onset and normal flow childbirth.

Utrozhestan can be prescribed during pregnancy in the following cases:

Lack of progesterone, threatening abortion.
The presence of discharge with an abnormal color containing blood.
Miscarriage prevention.
Recovery hormonal balance and pregnancy planning.

Side effects and contraindications for admission

When taking the drug Utrozhestan during pregnancy, there are a number of contraindications. If Utrozhestan is taken intravaginally during pregnancy, the ingredients of the capsule can only cause local allergic reaction: oily vaginal discharge, itching, burning.

Some women may experience dizziness, drowsiness, and symptoms of toxicosis may increase. Information about the system side effects not confirmed, but these risks are also worth bearing in mind.

Contraindications of the drug Utrozhestan during pregnancy:

individual intolerance to the components of the drug;
suspicion and presence oncological diseases reproductive organs and mammary gland;
diseases of the circulatory and cardiovascular systems (thrombophlebitis, strokes, heart attacks, etc.);
porphyria;
incomplete abortion;
vaginal bleeding of unknown origin.

Hepatic and renal insufficiency is a reason to be wary of taking the drug Utrozhestan during pregnancy. The physician must match possible risks and the expected benefit of the drug before its appointment, and then constantly monitor biochemical indicators blood and urine.

Method of application and dosage

It is prescribed to use Utrozhestan during pregnancy intravaginally, that is, to place the capsule deep into the vagina. You must take a shower before the procedure.

How to use Utrozhestan during pregnancy:

With the threat of termination of pregnancy, a daily dose of 200-400 mg of the drug is prescribed, which is divided into two doses. Daily Utrozhestan 200 during pregnancy is taken in the first or second trimesters. Reception is gradually reduced and canceled by the end of the 2nd trimester.
In the third trimester, a prophylactic course of Utrozhestan is carried out in cases of risk premature birth, with an unfavorable anamnesis, shortening of the cervix. Such patients can be prescribed the drug from the 22nd to the 34th week, 200 mg. The dose of the drug is taken once a day at bedtime.
With IVF, the gynecologist selects the dosage individually. The drug is started simultaneously with the hCG injection and continues until the 26th week. Maximum dose reaches 600 mg, usually it is divided into 3 doses per day. The dosage of Utrozhestan increases and is canceled gradually in accordance with individual indications.

The dosage of Utrozhestan depends on the level of hormones of a particular patient, so the doctor in each case can change the dosage regimen. Self-cessation and skipping the drug is not allowed.

The use of Utrozhestan when planning pregnancy

At the stage of pregnancy planning, the drug Utrozhestan can be prescribed in the following cases:

A decrease in the concentration of progesterone in the blood, occurring without severe symptoms.
Infertility due to lack of progesterone.
Having had a miscarriage in the past hormonal failure- Decreased progesterone levels.

Utrozhestan is appointed only after laboratory tests, which should confirm the need for taking the drug. To do this, you must select optimal time which depends on the menstrual cycle. The fact is that natural progesterone levels fluctuate constantly, so studies should be carried out after ovulation in the second phase of the cycle.

Progesterone deficiency is common among women. This condition makes it difficult to conceive and poses a threat to the harmonious development of the fetus. To prevent miscarriage, progesterone preparations should be taken during childbearing. As a result, Utrozhestan is not only prescribed when planning a child, but also in the first weeks of pregnancy.

progestational drug.

Preparation: UTROZHESTAN

Active ingredient: progesterone
ATX code: G03DA04
KFG: Gestagen
Reg. number: LS-000186
Date of registration: 22.04.05
The owner of the reg. acc.: Laboratoires BESINS INTERNATIONAL (France)

PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING

Capsules soft gelatinous, round, shiny, yellowish color; the contents of the capsules are an oily whitish homogeneous suspension without visible phase separation.

Excipients:

15 pcs. - blisters (2) - packs of cardboard.

Capsules soft gelatinous, oval, shiny, yellowish; the contents of the capsules are an oily whitish homogeneous suspension without visible phase separation.

Excipients: peanut oil, soy lecithin, gelatin, glycerol, titanium dioxide.

7 pcs. - blisters (2) - packs of cardboard.

The description of the drug is based on the officially approved instructions for use.

PHARMACHOLOGIC EFFECT

progestational drug. Progesterone, active substance drug Utrozhestan, is a hormone of the corpus luteum. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where it activates DNA and stimulates RNA synthesis.

It promotes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory phase. After fertilization, it contributes to the transition to the state necessary for the development of a fertilized egg. Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland.

By stimulating protein lipase, it increases fat reserves, increases glucose utilization. By increasing the concentration of basal and stimulated insulin, it contributes to the accumulation of glycogen in the liver, increases the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases the excretion of nitrogen in the urine.

Activates the growth of the secretory part of the acini of the mammary glands, induces lactation.

Promotes the formation of normal endometrium.

PHARMACOKINETICS

When taken orally

Suction

Micronized progesterone is absorbed from the gastrointestinal tract. The concentration of progesterone in the blood plasma gradually increases during the first hour, C max is observed 1-3 hours after ingestion.

The concentration of progesterone in the blood plasma increases from 0.13 ng / ml to 4.25 ng / ml after 1 hour, up to 11.75 ng / ml - after 2 hours and is 8.37 ng / ml after 3 hours, 2 ng / ml - after 6 hours and 1.64 ng / ml - after 8 hours.

Metabolism

The main metabolites that are determined in the blood plasma are 20-alpha-hydroxy-delta-4-alpha-pregnanolone and 5-alpha-dihydroprogesterone.

breeding

It is excreted in the urine as metabolites, 95% of which are glucuron-conjugated metabolites, mainly 3-alpha-pregnanediol and 5-beta-pregnanediol (pregnanediol).

These metabolites, which are determined in blood plasma and urine, are similar to substances formed during the physiological secretion of the corpus luteum.

When administered intravaginally

Suction

Absorption occurs quickly, progesterone accumulates in the uterus. High level progesterone is observed 1 hour after administration. Cmax of progesterone in plasma is reached 2-6 hours after administration. With the introduction of the drug at 100 mg 2 times / day, the average concentration remains at the level of 9.7 ng / ml for 24 hours.

When administered in doses of more than 200 mg / day, the concentration of progesterone corresponds to the first trimester of pregnancy.

Metabolism

It is metabolized with the formation of predominantly 3-alpha-pregnanediol and 5-beta-pregnanediol. The level of 5-beta-pregnanolone in plasma does not increase.

breeding

It is excreted in the urine as metabolites, the main part is 3-alpha-pregnanediol and 5-beta-pregnanediol (pregnanediol). It's confirmed constant increase its concentration (C max 142 ng/ml after 6 hours).

INDICATIONS

Conditions associated with progesterone deficiency, including:

for oral administration

Premenstrual tension syndrome;

Violations of the menstrual-ovarian cycle due to a violation of ovulation or anovulation;

Fibrocystic mastopathy;

premenopause;

Hormone replacement therapy for menopause (in combination with estrogenic drugs).

for intravaginal use

Hormone replacement therapy for progesterone deficiency with non-functioning (absent) ovaries (with egg donation);

Maintenance of the luteal phase during preparation for in vitro fertilization;

Maintenance of the luteal phase in a spontaneous or induced menstrual-ovarian cycle;

premature menopause;

Hormone replacement therapy (in combination with estrogenic drugs);

Infertility due to luteal insufficiency;

Prevention of habitual or threatened abortion due to progestin deficiency;

Prevention of uterine fibroids;

Prevention of endometriosis.

DOSING MODE

The duration of therapy is set individually, depending on the clinical situation.

oral route introductions

The drug should be taken orally with water. In most cases, progesterone deficiency daily dose Utrozhestan is 200-300 mg, divided into 2 doses (morning and evening).

At luteal phase insufficiency(premenstrual tension syndrome, menstrual disorders, fibrocystic mastopathy, dysmenorrhea, premenopause) the daily dose of the drug is 200 or 400 mg, divided into 2 doses (morning and evening), for 10-12 days (usually 17-26 days of the cycle ).

At hormone replacement therapy in premenopause while taking estrogens, Utrozhestan is used at 200 mg / day for 10-12 days.

Intravaginal route of administration

At total absence progesterone in women with non-functioning (missing) ovaries(egg donation) the drug is administered intravaginally against the background of estrogen therapy at 200 mg / day on the 13th and 14th days of the cycle, then 100 mg 2 times / day from the 15th to the 25th day of the cycle, from the 26th day and in case determining pregnancy, the dose increases by 100 mg / day every week, reaching a maximum (800 mg / day), divided into 3 injections. This dose is usually applied for 60 days.

For maintenance of the luteal phase during the in vitro fertilization cycle it is recommended to administer intravaginally from 400 to 800 mg / day, starting from the day of injection chorionic gonadotropin throughout the entire duration of pregnancy.

For maintaining the luteal phase in a spontaneous or induced menstrual-ovarian cycle, with infertility associated with dysfunction of the corpus luteum, it is recommended to administer intravaginally at 200-300 mg / day, starting from the 17th day of the cycle for 10 days, in case of delayed menstruation and diagnosis of pregnancy, treatment should be continued.

At the threat of termination of pregnancy or in order to prevent habitual abortions that occur against the background of progesterone deficiency, administered intravaginally at 200-400 mg daily in 2 doses (morning and evening) in the I and II trimesters of pregnancy.

The capsules are inserted deep into the vagina.

SIDE EFFECT

From the side of the central nervous system: when taken orally - drowsiness, transient dizziness (1-3 hours after taking the drug).

From the reproductive system: when taken orally, very rarely - intermenstrual bleeding.

Others: allergic reactions.

CONTRAINDICATIONS

Tendency to thrombosis;

Acute phlebitis or thromboembolism;

Bleeding unclear etiology from the genital tract;

incomplete abortion;

Porfiria;

Established or suspected malignant neoplasms of the mammary glands;

Established or suspected malignant neoplasms of the genital organs;

Severe liver dysfunction (for oral administration);

Hypersensitivity to the components of the drug.

FROM caution the drug should be used in diseases of the cardiovascular system, arterial hypertension, chronic kidney failure, diabetes, bronchial asthma, epilepsy, migraine, depression, hyperlipoproteinemia, in the III trimester of pregnancy and during lactation.

PREGNANCY AND LACTATION

Utrozhestan is indicated for use in the I and II trimesters of pregnancy.

Use with caution in the third trimester of pregnancy (due to the risk of liver dysfunction) and during lactation.

SPECIAL INSTRUCTIONS

Utrozhestan should not be used for contraception.

Influence on the ability to drive vehicles and control mechanisms

When taking the drug inside, care should be taken when taking potentially dangerous species activities requiring heightened attention and speed of psychomotor reactions.

OVERDOSE

Side effects most often indicate an overdose and disappear spontaneously with a decrease in the dose of the drug.

DRUG INTERACTIONS

At joint application Utrozhestan enhances the effect of diuretics, antihypertensive drugs, immunosuppressants, anticoagulants.

Utrozhestan reduces the lactogenic effect of oxytocin.

TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES

The drug is dispensed by prescription.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.