Treatment of drug-induced hepatitis. drug-induced hepatitis

Chronic hepatitis called a group of liver pathologies that occur against the background of various factors and are characterized by the appearance of an inflammatory process and necrosis of gland cells varying degrees gravity. According to modern international classification, drug-induced hepatitis is one of the representatives of diseases of this group. The following are the manifestations of the disease, the reasons why it develops, and the answers to the question of whether it is possible to cure a pathology with such a formidable name.

Drug-induced hepatitis is a lesion of hepatocytes (liver cells), which develops under the influence of decay products of various medications. Pathology occurs against the background of ongoing intensive treatment in every sixth to seventh patient. In a quarter of these patients, the disease progresses to more complex conditions (for example, replacement of liver cells connective tissue with further loss of performance). It is known that females are several times more likely to develop drug-induced hepatitis than males.

Exist the following forms diseases:

spicy drug-induced hepatitis(cholestatic, cytolytic and combined type);
chronic drug-induced hepatitis (CLH).

The liver is considered one of the largest organs. Its functions are to inactivate toxins and toxic substances, cleanse the body, produce bile, form and destroy blood cells. Purification is carried out due to specific enzymatic processes that occur inside hepatocytes. As a result, the substances neutralized by the liver are excreted from the body.

The destruction of substances toxic to humans occurs in the form of several successive processes during which specific products are formed. Such decay products of a number of drugs are even more toxic to the gland than themselves. medications.

Prolonged use of medications or high dosage lead to depletion of enzymatic systems and damage to liver cells. The result is the development of toxic drug-induced hepatitis.

The modern pharmacological market has more than 1000 drugs that can provoke the development of the disease. negative impact on the liver increases several times with the combined use of several drugs, and with the simultaneous use of 6 or more types of drugs, the risk of developing the disease increases to 85%. The process of formation of liver pathology can occur from 3-4 days to several years.

Factors provocateurs

The main factors that can provoke the occurrence of drug-induced hepatitis:

individual sensitivity to active substances medicines;
chronic hepatitis of a different nature;
development of ascites (accumulation of fluid in abdominal cavity);
alcohol abuse;
toxic effect of toxic substances entering the body in the course of performing professional duties;
the period of bearing a child;
insufficient intake of protein substances with food;
stressful situations;
severe pathologies of the heart and kidneys.

The only condition for the development of pathology is the combined action adverse factors and drug therapy.

The list of drugs that can provoke the development of drug-induced hepatitis:

Drugs used to combat tuberculosis bacillus (Isoniazid, PAS).
Hormonal agents (combined oral contraceptives, steroids).
Diuretics (Veroshpiron, Hypothiazid).
Antiarrhythmic drugs (Amiodarone).
Antibacterial drugs (representatives of penicillins, macrolides, tetracyclines).
Sulfanilamide preparations (Biseptol, Sulfalen).
Antimycotics (Ketoconazole, Amphotericin B).
Anticancer drugs (Methotrexate).
Non-steroidal anti-inflammatory drugs (Diclofenac).

This is not the whole list of drugs, against the background of which drug-induced hepatitis can develop.

Manifestations of the disease

Symptoms of drug-induced hepatitis depend on the course of the disease, the severity of the pathological process. The clinical picture is similar to other forms of hepatitis. The patient complains of vivid manifestations from the side gastrointestinal tract: attacks of nausea and vomiting, flatulence, a sharp decline appetite, bitter belching, stool problems.

There is cephalgia, discomfort and heaviness in the projection of the affected organ. When conducting palpation, the attending physician determines the presence of pain, an increase in the size of the liver. The progression of the pathology is accompanied by the development of jaundice. The skin and sclera of the patient become yellow, the feces become discolored, and the urine, on the contrary, acquires a dark shade. There is itching of the skin, the presence spider veins, rashes of various nature.

known clinical cases when the disease was in full swing diagnosed by laboratory analysis, and the patient was not even aware of its presence due to the absence of symptoms.

Diagnostics

The diagnostic process begins with the collection of an anamnesis of life and illness, visual inspection patient, palpation of the affected area. Further, general tests (blood, urine), determination of the state of the blood coagulation system are prescribed,
biochemistry (indicators of ALT, AST, bilirubin, alkaline phosphatase, protein fractions).

Ultrasound examination of the liver will determine the increase in the size of the liver (sometimes along with the spleen), heterogeneous structure her tissues. The specialist must exclude other types of hepatitis (alcoholic, viral, autoimmune). This may require a liver biopsy, which can determine the absence of specific changes in hepatocytes. As a rule, the presence of a large number of eosinophils, granulomas, a clear line between unaffected tissue and areas of cell death is confirmed.

To conduct a differential diagnosis with viral hepatitis, serological tests and PCR are prescribed.

Features of treatment

The treatment regimen is developed by a specialist hepatologist. Treatment of drug-induced hepatitis should be timely. This will help to avoid the transition of the disease into cirrhosis or liver failure. Basic principles:

The drug that caused the disease should be discontinued. A similar issue is considered with those specialists who prescribed therapy. concomitant diseases. If necessary, replace with another medication.
Detoxification treatment of drug-induced hepatitis - purification of the patient's blood from those metabolites that act on the body in a toxic way. To do this, infusion with Hemodez is carried out, if necessary, hemodialysis or plasmapheresis is used, the introduction of specific antidotes.
Restorative therapy with hepatoprotectors - drugs that protect the gland from negative impact external and internal factors, restoring functional state hepatocytes. Representatives - Gepabene, Karsil, Heptral.
Therapy aimed at eliminating symptomatic manifestations(eg, antiemetics, sorbents).

Power correction

Diet for drug-induced hepatitis - link complex treatment pathology. Experts recommend that the patient not only follow medical nutrition but also to change habits, lifestyle in general.

Patients must follow the rules of table number 5. This diet is prescribed for all types of hepatitis, cirrhosis, liver failure. Peculiarities:

Liver pathology requires compliance drinking regime. Sufficient quantity liquid maintains indicators of water and electrolyte balance, reduces the viscosity of bile, helps to stop the inflammation process.

You can use mineral waters with sulfate groups. They activate the work of the intestinal tract, reducing the load on the liver, normalize the outflow of bile, eliminate spasms structural elements biliary system. These waters can be used for therapeutic baths(duration - 10 minutes, temperature - 36 ° C, number - 10-12 procedures).

Sample menu for drug-induced hepatitis

Breakfast - low-fat cottage cheese with the addition of a banana, tea.

Snack is an apple.

Lunch - vegetable soup, boiled chicken fillet, salad fresh vegetables.

Snack - yogurt.

Dinner - rice, fish, baked vegetables.

Snack - a glass of tea, biscuit cookies.

Prevention

Preventive measures to prevent the development of drug-induced hepatitis include timely diagnosis state of the body (including the liver), refusal to drink alcohol and smoking. The choice of treatment for any pathology should be carried out qualified specialist after full comprehensive examination patient. When prescribing hepatotoxic medicinal medicines hepatoprotectors should be taken.

drug-induced hepatitis serious illness, which can develop at lightning speed, even lead to hepatic coma and death. To avoid this, you should abandon self-medication, seek medical help in a timely manner and follow all the prescribed recommendations. In this case, a favorable prognosis can be achieved.

Drug-induced hepatitis is a liver disease characterized by the occurrence of inflammatory processes in hepatocytes under the influence of pharmacological preparations. Approximately 25% of people undergoing therapy various pathologies experience drug-induced hepatitis. In women, this disease is diagnosed several times more often than in men and occurs with numerous complications. Doctors attribute this to the commitment of the fair sex to self-medication.

Pathogenesis

liver disease

Cells are exposed to intoxication even under the influence of conventional diuretics and analgesics. Doctors never tire of repeating that self-medication is extremely dangerous, but every year thousands of people end up in hospital beds who have destroyed their livers by uncontrolled medication. The fact that many pharmacological drugs have toxic properties is known to physicians and is prescribed to patients with the greatest care only if the benefit outweighs the risk.

The liver is a universal biological filter for neutralizing blood from toxic substances and metabolic products. Medicines are not capable of causing tangible harm in sparing dosages. Specific proteins enter into chemical reactions with the formation of large molecules - metabolites. Unnecessary metabolites for the body are excreted from the body, the rest go to the target organs for further treatment.

If a person begins to abuse the intake of pharmacological drugs, then hepatocytes cease to cope with excessive load. Metabolites begin to accumulate in the liver tissues and provoke intoxication. end result irreversible deformation of hepatocyte cells becomes a negative process.

Etiology

Drug-induced hepatitis can develop in the human body for several reasons. Doctors identify three main factors leading to the death of liver cells:

Proteins are the building blocks of liver cells. Therefore, people who follow monotonous diets are at risk. In the absence of proteins and their metabolic products, there is no complete breakdown of molecules chemical compounds.

What drugs cause drug-induced hepatitis

The toxic effect of drugs is enhanced when they are taken simultaneously with alcohol and other drugs repeatedly. Toxic hepatitis provokes the presence of diseases in humans:

chronic renal failure;
cardiovascular insufficiency;
circulatory disorders.

All these pathologies require in the treatment of long-term use of drugs that have negative impact on liver cells. toxic action may have only one of the drugs or a combination of them. These medicines include:

Anticancer drugs and cytostatics.
Non-steroidal anti-inflammatory drugs.
Antibiotics and antimicrobials.
Anti-tuberculosis drugs.
Sulfonamide preparations.
Anticonvulsants.
Fungicidal preparations.
Antiepileptic drugs.
Medicines for treatment diabetes and thyroid diseases.
Antiarrhythmic drugs.

The above medicines have pronounced hepatotoxic properties. This does not mean that you can use other pills uncontrollably. Even "harmless" Analgin and Aspirin can cause drug-induced hepatitis and fatal intoxication.

Kinds

There are several classifications of drug-induced hepatitis, but when diagnosing, doctors use two main ones, based on the methods of the upcoming treatment:

Directed toxic effect. In this case, doctors predict the occurrence of drug-induced hepatitis and try to take measures to reduce dangerous side effects. But without the use of these medicines, a person's life is at mortal risk.
indirect toxic effects. Precautions that are not always taken can prevent the development of drug-induced hepatitis. hereditary predisposition organism to this complex of chemical compounds is capable of provoking the development of drug-induced hepatitis.

Distinguish between acute and chronic stage liver disease. Acute drug-induced hepatitis occurs about ten days after taking a pharmacological drug. A person may already forget about the use of the drug, and at this time the liver cells in his body are rapidly destroyed. This situation occurs extremely rarely and only in two cases. At individual intolerance drug, accompanied by the manifestation of extensive symptoms allergic reaction, as well as when taking a drug that has a pre-predicted toxic effect.

Chronic drug-induced hepatitis often occurs without any clinic. The patient can find out about the presence of the disease in diagnosing the pathology of the neighboring internal organ. The destruction of liver cells occurs over several months or years. How this or that drug will affect hepatocytes cannot be determined even approximately. The insidiousness of the disease lies in the frequent absence of bright severe symptoms. CLH is diagnosed in patients who are forced to regularly take pharmacological drugs to treat systemic pathologies.

Symptoms

You should immediately contact medical institution, if any the following symptoms medicinal hepatitis:

TO side symptoms drug-induced hepatitis includes arterial hypertension, which, with an increase in intoxication, is replaced by sharp drop pressure.

Diagnostics

Diagnosis begins with a questioning of the patient by the attending physician and the study of diseases in his anamnesis. If a person's skin turns yellow, and during palpation the liver is clearly enlarged, the doctor will immediately suspect toxic hepatitis. To confirm the diagnosis, the patient will need to take biochemical tests:

blood. The platelet concentration makes it possible to assess general state human health.
Urine. An increased content of leukocytes and protein breakdown products indicates the presence of an inflammatory focus.
Determination of bilirubin, AST.

Before treating the pathology, a coagulogram is prescribed to determine the level of blood clotting. Conducted if necessary ultrasonography, CT scan, Magnetic resonance imaging.

Symptoms and treatment of drug-induced hepatitis are closely related to the level of transaminases - liver enzymes. The increase in their concentration is directly dependent on the number of damaged hepatocytes. That is why it is extremely important to check the level of transaminases when taking any drugs.

Therapy

Treatment of drug-induced hepatitis begins with the abolition of the drug that provoked the disease. Cancellation should occur upon agreement with the attending physician and after passing the tests. The doctor can completely change the drug or reduce its dosage.

In order to prevent possible development encephalopathy, detoxification therapy is carried out using drugs and (or) devices to remove accumulated toxins from the body. After blood disinfection, treatment of drug-induced hepatitis with hepatoprotectors is started. Medicines that can restore damaged liver cells include: Essentiale forte, Heptral, Essliver forte, Gepabene, Phosphogliv and Phosphogliv forte.

To strengthen the state of the body, doctors recommend that patients take it according to the scheme vitamin complexes And minerals. Antispasmodics will help relieve painful spasms: No-shpa, Spazmalgon, Spazgan.

Therapy will not bring results if the patient does not adhere to a diet for drug-induced hepatitis. For patients with any liver diseases, "Table No. 5" is suitable, the observance of which includes the following rules:

exclusion from the diet of salty, fried, spicy and fatty foods;
small meals up to 6 times a day;
quitting smoking and drinking alcohol;
preference for products big amount carbohydrates.

Adhering to a diet, vitamins and additional amino acids should be consumed. To prevent dangerous relapses and in order to never know what drug-induced hepatitis is, it is necessary to stop taking pharmacological drugs that are not prescribed by the attending physician.

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Drug-induced hepatitis is an inflammatory process in the liver, provoked by certain medications. If the treatment of the disease is not started in a timely manner, then the onset of necrotic processes in the affected organ and cirrhosis is quite possible. In advanced stages is no exception death. According to statistics, drug-induced hepatitis is three times more likely to be diagnosed in women than in men. This circumstance scientific explanation does not yet have.

Etiology

The main cause of drug-induced hepatitis is long-term use and high dosage of hepatotoxic drugs. Their impact leads to the depletion of enzymes that neutralize active ingredients medicines, and damage to the cells of the organ.

To the risk factors for the formation this disease should include:

presence in history;
abuse of alcohol and surrogates;
contact with toxic substances;
pregnancy;
irrational nutrition;
prolonged nervous tension;
genetic predisposition.

TO medications that can provoke the development of toxic drug-induced hepatitis should include:

antibiotics, especially of the tetracycline group;
anti-tuberculosis;
cytostatics;
diuretics;
non-steroidal anti-inflammatory;
antimicrobial;
proton pump inhibitors;
hormonal;
antidiabetic;
drugs for the relief of epileptic seizures and seizures.

It should also be understood that a moderate intake of drugs from this list, subject to the doctor's recommendations and with a strong immune system should not be considered as a 100% predisposition to the development of drug-induced hepatitis.

It should be noted that this species disease has no clear incubation period. This disease can form both within a few years of taking medications, and after a few weeks from the start of treatment with certain medications.

Some patients develop chronic drug-induced hepatitis that is difficult to treat. As a rule, this form of the disease occurs in people who are forced to take certain medications constantly.

Classification

According to the nature of the course of the disease, two forms are distinguished:

acute - characterized by an intense clinical picture, relatively well treatable;
chronic form - often develops over several years, responds poorly to therapy, often leads to.

Regardless of what caused the development of this pathological process, treatment should begin immediately.

Symptoms

Symptoms of drug-induced hepatitis are almost identical clinical picture viral hepatitis. The clinical picture is manifested as follows:

pain, feeling of heaviness in the right hypochondrium;
nausea, often with vomiting. Sometimes vomit may have bile impurities;
general weakness, malaise;
violation of the functioning of the gastrointestinal tract;
bouts of diarrhea after eating fatty, heavy foods;
feeling of heaviness in the stomach, even with minimum quantity food consumed;
yellowness of the skin;
itching on the body;
saturated dark color urine;
discoloration of feces;
enlargement of the liver and spleen.

It should be noted that chronic drug-induced hepatitis (CLH) long time may be asymptomatic. In some cases, the patient may be disturbed, especially while taking medication, periodic pain in the abdomen, heaviness in the right hypochondrium and a short disruption of the functioning of the gastrointestinal tract. Symptoms may disappear completely after stopping the use of drugs. That is why, the chronic form of the disease is often diagnosed at an advanced stage.

The manifestation of such symptoms does not always indicate drug-induced hepatitis, so you cannot take the treatment yourself. Such medical measures can aggravate the development of the pathological process, which can also lead to the formation of concomitant diseases. No exception and death.

Diagnostics

If you have the above symptoms, you should consult a doctor. After clarifying the complaints, anamnesis of the disease and life, the doctor prescribes an examination.

The diagnostic program may include the following methods:

general and biochemical analysis blood;
general urine analysis;
coagulogram;
coprogram;
Ultrasound of the abdominal organs;
liver biopsy.

Since the clinical picture is rather ambiguous and may be a manifestation of other liver diseases, it is carried out differential diagnosis to exclude or confirm such diseases:

oncological process;
liver tumor;

The therapy program will be prescribed by the attending physician after precise setting diagnosis and identification of the etiology of the disease.

Treatment

Treatment of drug-induced hepatitis is only complex, in compliance with diet therapy.

First of all, hepatotoxic drugs are canceled. Then, detoxification therapy is prescribed.

To be excreted from the body toxic substances appointed:

infusion therapy;
in more severe cases - plasmapheresis and hemodialysis.

Drug therapy involves the replacement of a hepatotoxic drug with safe analogue. If this is not possible, then hepatoprotectors are prescribed to prevent the development of chronic drug-induced hepatitis.

The duration of medication, dosage and regimen is prescribed strictly by the attending physician. Making unauthorized adjustments to the course of treatment is unacceptable.

The treatment program for both acute and chronic drug-induced hepatitis necessarily includes diet therapy. The diet for toxic drug-induced hepatitis involves the exclusion of the following:

alcohol;
fatty meats, fish, offal;
products with high content cholesterol;
cocoa, strong tea, coffee;
chocolate;
products containing oxalic acid.

The diet of the patient should consist of lungs, but at the same time nutritious foods. The diet implies the following daily protein-energy composition:

carbohydrates - 350-400 grams;
fats - no more than 90 grams, of which 30 grams are of vegetable origin;
proteins - no more than 100 grams, of which 60 grams of animal origin;
table salt no more than 4 grams per day.

Food should only be warm, steamed or boiled. The preferred consistency of dishes is liquid, grated, puree. The patient's diet should be frequent (4-5 times a day), in small portions and with an interval of 2.5-3 hours.

It is also important to observe the drinking regimen. The amount of liquid drunk per day should be at least two liters. It is recommended to use mineral water without gas.

Forecast

If treatment for drug-induced hepatitis is started in a timely manner, it is possible full recovery functioning of the liver. Otherwise, the development of serious pathological processes is possible - cirrhosis of the liver,. Lethal outcome is not excluded.

Prevention

Preventive measures for this disease are as follows:

taking only medicines prescribed by the doctor and observing their dosage;
timely and proper treatment all diseases;
preventive examination by specialized medical specialists.

If you have any of the above symptoms, you should seek help from a qualified medical professionals rather than self-medicate.

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Answer only if you have proven medical knowledge

Diseases with similar symptoms:

Jaundice - pathological process, the formation of which is influenced by a high concentration of bilirubin in the blood. The disease can be diagnosed in both adults and children. call like this pathological condition capable of any disease, and they are all completely different.

- reactive inflammatory lesion liver caused by taking hepatotoxic drugs. Signs of drug-induced hepatitis may include nausea, vomiting, loss of appetite, constipation or diarrhea, jaundice, dark urine, and light-colored feces. Diagnosis of drug-induced hepatitis is made on the basis of anamnesis, determination of the level of liver tests, ultrasound of the liver. Treatment of drug-induced hepatitis requires the abolition of the pharmaceutical product that caused liver damage, detoxification therapy, and the appointment of hapatoprotectors.

The main groups of drugs that cause drug-induced hepatitis include:

Tuberculosis drugs (rifampicin, isoniazid)
Antibiotics: tetracyclines (tetracycline, chlortetracycline, dixycycline), penicillins (benzylpenicillin, amoxicillin, etc.), macrolides (erythromycin)
Sulfonamides (sulfamethoxazole + trimethoprim, sulfadimethoxine, etc.)
Hormones ( steroid hormones, oral contraceptives, etc.)
NSAIDs (diclofenac, ibuprofen)
Anticonvulsants and antiepileptics (phenytoin, carbamazepine, clonazepam, etc.)
Antifungals (amphotericin B, ketoconazole, fluorocytosine)
Diuretics (hydrochlorothiazide, furosemide, etc.)
Cytostatics (methotrexate)
Drugs for the treatment of arrhythmias, diabetes mellitus, peptic ulcer and many others. others

The list of drugs that have a hepatotoxic effect is far from being exhausted by the named drugs. Drug-induced hepatitis can be caused by almost any medicine and especially - a combination of several drugs.

Symptoms of drug-induced hepatitis

Drug-induced hepatitis can occur in acute or chronic form. Acute drug-induced hepatitis, in turn, are divided into cholestatic, cytolytic (occurring with necrosis and fatty hepatosis) and mixed.

The symptoms of drug-induced hepatitis are similar to those of other types of hepatitis. dominant in the clinical picture are dyspeptic disorders: loss of appetite, nausea, belching bitterness, vomiting, diarrhea or constipation, weight loss. Main clinical manifestations may be preceded by a prodromal period that occurs with asthenic or allergic syndrome. With drug-induced hepatitis, moderate pain, heaviness, discomfort in the right hypochondrium are disturbing; palpation determines hepatomegaly, liver tenderness. Sometimes jaundice develops against the background of drug-induced hepatitis, pruritus, fever, lighter stools and darker urine.

In some cases, drug-induced hepatitis can be detected only on the basis of changes in biochemical indicators blood. Acute drug-induced hepatitis, which proceeds with the formation of submassive necrosis, quickly leads to cirrhosis of the liver. With massive necrosis of the liver, liver failure develops.

Diagnostics

In the process of diagnosing drug-induced hepatitis, it is important to exclude viral hepatitis, cholelithiasis , liver tumors , pancreatic cancer . When taking anamnesis, it is important to find out the causal relationship of liver damage with the use of hepatotoxic drugs.

If drug-induced hepatitis is suspected, biochemical liver tests are examined, in which the activity of transaminases (AST, ALT) and alkaline phosphatase, the level of bilirubin, and globulin fractions increase. A coagulogram study is carried out, general analysis urine and blood, coprograms.

Ultrasound of the abdominal organs reveals diffuse magnification liver, however, does not allow us to judge the cause of hepatitis.

Treatment of drug-induced hepatitis

The first step in treating drug-induced hepatitis is to stop the drug suspected of causing liver damage and replace it with a safer alternative. It is strictly forbidden for the patient to change medications on his own. In order to remove toxic metabolites from the body, detoxification infusion therapy, plasmapheresis, and, in severe cases, hemodialysis are performed.

To restore damaged liver cells, hepatoprotective drugs (essential phospholipids, ademethionine, methionine) are prescribed. When prescribing drugs with a known hepatotoxic potential, it is recommended to take preventive hepatoprotectors, which helps prevent the development of drug-induced hepatitis.

Forecast and prevention

In severe cases, with lightning-fast development drug-induced hepatitis or massive necrosis of the hepatic parenchyma develops cirrhosis, liver failure, sometimes hepatic coma and death. With the timely cancellation of the hepatotoxic drug in most cases, complete recovery occurs.

Prevention of drug-induced hepatitis is rational use medications, monitoring side effects, taking drugs only as prescribed by a doctor, avoiding additional toxic influences. Against the backdrop of a long drug therapy the appointment of hepatoprotectors is recommended. Patients who are forced to take medication for a long time should periodically examine the level of transaminases in order to identify drug-induced hepatitis at an early stage.

Drug-induced hepatitis is a disease in which a reactive inflammatory process occurs in the liver. It begins when a person takes hepatotoxic medical preparations. Hepatocytes are affected.

These are liver parenchyma cells that are involved in many processes:

protein synthesis and storage;
cholesterol synthesis;
detoxification;
synthesis of lipids and phospholipids;
removal of endogenous elements from the body;
bile initiation.

Drug metabolites contribute not only to the development of the inflammatory process, but also lead to cell necrosis, liver cirrhosis and liver failure. In men, drug-induced hepatitis is less common, mainly inflammatory process women are susceptible.

There is another type of disease, namely. It develops against the background of poisoning with pesticides, fungal toxins, industrial alcohol.

Toxic hepatitis occurs not only when a person has eaten or drunk something, infection can occur through Airways or pores skin. Contact with industrial poisons can provoke such a disease.

Very often, doctors are faced with mushroom poisoning. This is toxic hepatitis. But in most cases it leads to death.

Causes of Hepatitis

The liver can be called the ideal filter in all of nature. It is responsible for neutralizing and removing toxic substances that enter it with the blood. When the blood contains for a long time a large number of drug metabolites, liver cells begin to break down. Conclusion harmful substances from the body occurs in several stages. In the process of this, the formation of metabolites (intermediate products of biological transformation) occurs. Medicinal preparations contain too hepatotoxic elements that have a detrimental effect on cells and the liver as a whole.

If a person takes for a long time such drugs, there is a depletion of the neutralizing enzymatic system, damage to hepatocytes. As a result, drug-induced or drug-induced hepatitis begins to develop. Today, about 1000 drugs are known that can provoke hepatitis. The risk of inflammation of the liver cells increases tenfold if several drugs are taken at once. Simultaneous reception 8-9 medications increase hepatocyte damage by 93%. The process of development of the disease can take from 2 days to 1 year. Also, the reasons may be:

Drug-induced hepatitis occurs mainly if the dosage of medications is violated or the wrong combination of their intake is made.

Drug-induced hepatitis: symptoms and signs

With drug-induced hepatitis, the same symptoms occur as with all known varieties of the disease. These include:

fatigue;
weakness;
sleep disorders;
recurrent headache;
yellowing of the skin and whites of the eyes;
pain and heaviness in the liver (right hypochondrium);
bitter taste in the mouth;
loss of appetite;
diarrhea;
nausea, vomiting;
intense weight loss.

Since hepatitis has the same symptoms as hepatitis A, hepatitis B, hepatitis C, treatment can only be prescribed by a doctor after complete examination. In no case should you self-medicate or try to correct the situation with medicines, even those miraculous medicines that commercials talk about. This can only aggravate the situation and personally contribute to an even more intensive development of the disease.

Treatment of drug-induced (medicated) hepatitis

Treatment for drug-induced hepatitis begins with diagnostic examination and delivery of analyses. It is very important to understand that a person really has drug-induced hepatitis, because the course of treatment depends on it. Diagnosis is carried out by such methods as:

general analysis of blood and urine;
biochemical blood test (determination of the level of bilirubin in the blood, bilirubin and protein fractions);
study of the blood coagulation system (coagulogram);
palpation;
Ultrasound of the liver.

In the event that the disease is confirmed, doctors cancel the drug, which is toxic to liver cells. Subsequently, the complex curative measures, which will help to remove the poison and neutralize the body. In medicine, such procedures are called detoxification therapy. To cleanse the body, special preparations are used.

To restore the liver, there are substances that contribute to the rapid and effective regeneration liver cells, their division.

When there are severe necrotic and cirrhotic lesions of the liver cells, organotherapy is used, which contributes to quick recovery hepatic tissues.

Diet for drug-induced hepatitis

The risk group is people who have already had cases in their family chronic diseases liver or hepatitis. Those who have problems with alcohol or who are constantly taking medication to restore one or another organ are at risk.

People who are at risk, and those who do not want to have liver problems, should take the most the best remedy for prevention. It's about about grass (thistle). It should be noted that all drugs that restore liver function are created on the basis of this natural medicine.

In order to prepare a decoction, you need 2 tbsp. l. crushed seeds pour 0.5 liters of boiling water and leave for 10-12 hours.

After that, strain the broth. Take 100 ml 5 times a day.

In addition, a person diagnosed with drug-induced (medicated) hepatitis must necessarily adhere to a certain diet. The liver is not "friendly" with:

alcohol and nicotine;
stress;
overweight;
sweets and pastries in large quantities;
spicy foods and spices;
lamb, fatty pork, lard;
smoked products, pickled vegetables and fruits;
canned food;
mushrooms.

The diet should be based on products with:

maximum reduced level cholesterol and fat;
plenty of fiber, vegetables and fruits.

In chronic (drug) hepatitis, doctors recommend:

avoid trans fats (margarine, fat, fast food, crackers, canned food);
reduce as much as possible the consumption of foods containing saturated fat (butter, ice cream, homemade milk, fried foods);
try to eat as many fresh fruits and vegetables as possible (but it is not recommended to replace them with juices or dried fruits);
eat whole grains, vegetable proteins, legumes;
eat chicken, pigeon, rabbit, veal, lean and unsalted fish;
consume less sugar, salt;
drink at least 2 liters of fluid per day;
not to starve;
eat boiled or baked foods.