Instructions for use Claritin: pharmacological properties of the drug, dosage, analogues. Claritin - reviews, price, analogues, release form Claritin tablets instructions for use

Allergy is a pathognomonic process in the human body, which is the response of the body to the repeated introduction of the allergen. This is an increased reaction of the immune system to a "foreign" object in the human body.

- a modern antihistamine that is harmless to use in adults and children to reduce and eliminate allergy symptoms.

There are several generations of H receptor blockers:

• First generation- medicinal substances acting on peripheral H1-histamine receptors have a mild effect on allergens and a pronounced calming effect on the central nervous system.
• Second generation blockers of receptors involved in the occurrence of allergies are aimed at stabilizing the mast cell membrane, histamine receptors. Accordingly, they have a less pronounced effect on the relief of allergy symptoms, but do not inhibit the work of the central nervous system.
• third generation drugs affect the mast cell membrane, do not cause the effect of depression of the nervous system, have a pronounced anti-allergic effect by interacting with peripheral H1 receptors. This selective action provides drugs with minimal side effects.

Claritin belongs to the third generation of antiallergic drugs that have a minimal inhibitory effect on the nervous system and a maximum antiallergic. These drugs are active metabolites, ie. formed directly in the human body.

The main advantage of Claritin is its extremely selective effect on allergen-affected receptors. Due to this, patients taking the drug have fewer side effects.

Forms of release and composition

Claritin is available in the following forms:

• pills;
• syrup in children's dosage.

The composition of both drugs is similar, the comparative difference lies only in the dosage of the main active substance - Loratadine.

Additional substances:

• lactose monohydrate;
• corn starch;
• magnesium stearate.

Pills

Claritin tablets from allergies has an ovoid shape and white color without inclusions and impurities.

On one of the surfaces of the allergy pill there is an indented strip, and on the other there is a branded icon with a flask with the number 10.

Claritin can be purchased at a pharmacy for 1, 2 or 3 blisters in a cardboard box. Accordingly, the number of tablets can be 7, 10 and 30 pieces per pack.

Syrup

Syrup Claritin produced in 60 and 120 ml in an individual dark glass bottle.

A solution of white or slightly yellowish color is absolutely homogeneous.

The drug in this form has no sediment and inclusions.

A dark glass bottle is placed in a branded cardboard box marked "anti-allergic for children."

Therapeutic effects and action

The main mechanism of action of Claritin is the blocking of H1-histamine receptors. This leads to the formation of a pronounced antiallergic effect. It has been proven that Claritin reduces itching of the skin and mucous membranes - the main symptoms of allergies.

The rapid onset of the clinical effect and the lack of effect on the muscle tissue of the heart is the main advantage of the drug. Helps relieve spasm of smooth muscles in severe allergy symptoms.

Due to the fact that Claritin contributes to the narrowing of small blood vessels and reduces their permeability, the drug can be used to relieve swelling of the skin and mucous membranes during an allergy attack.

After ingestion, the effect occurs after 30 minutes and lasts about 24 hours.

Indications for use

Claritin for allergies has the following indications for use:

Being a prodrug - an active metabolite - Claritin eliminates the painful symptoms of allergies - itching, burning and redness.

When ingested, the agent relieves swelling of the mucous membranes caused by the allergen, helps to reduce inflammation.

The purpose of Claritin for skin symptoms of allergy is justified by its pronounced effect on target cells, which reduces skin irritation.

Claritin for allergies: how to use

Proper use of the drug in the form of tablets:

Proper use of the drug in the form of syrup:

Use during pregnancy and lactation

Clinical studies of the drug Claritin for allergies in pregnant women have not been conducted.

In this regard, if it is necessary to prescribe antihistamines, it is necessary to assess the possible risk to the fetus.

Loratadine is excreted in breast milk, therefore, during lactation, the issue of stopping breastfeeding for the entire period of treatment from allergy symptoms with the attending physician is being decided.

After the end of treatment, breastfeeding should not be resumed within 48 hours after the last dose of the drug.

special instructions

• Claritin is used with caution in patients with liver and kidney disease. It is necessary to take into account renal clearance and glomerular filtration rate, as well as to monitor the indicators of the general and biochemical blood tests in patients taking this drug for a long time.
• If it is necessary to conduct skin tests, Claritin should be stopped at least 48 hours in advance, otherwise the result of the study will not be informative.

During clinical studies, there was no interaction between the influence of Claritin on the performance of work requiring increased concentration.

However, with an individual reaction of increased drowsiness after taking the drug, it is necessary to protect yourself from performing these types of work.

drug interaction

Co-administration of Claritin for allergies with ketoconazole, cetirizine and erythromycin causes a therapeutically insignificant increase in these drugs in plasma. It is recommended to avoid long-term co-administration of these groups of drugs.

Interaction with alcohol

Studies have shown that Claritin does not increase the effects of alcohol on the CNS.

This can lead to impaired absorption of the drug, the appearance of unwanted symptoms.

Side effects

In clinical studies involving adults, adverse events, which were observed more often than with the use of a pacifier, occurred in 2% of patients taking the drug Claritin.

The following effects have been noted:

• Increased nervous excitability;
• Fast fatiguability;
• Headache and dizziness;
• Sleep disturbance;
• Increased appetite;
• dry mouth;
• Nausea, vomiting and pain in the epigastric region;
• Bitterness in the mouth;
• Pain in the right hypochondrium;
• Increased heart rate;
• Hair loss.

Side effects of Claritin in children:

• Headache may appear;
• There is drowsiness;
• Increased appetite;
• The worst thing is insomnia;
• Rarely - dizziness, fatigue, a feeling of dry mouth;
• Disorders of the stomach and intestines, skin rash, cramps in the limbs and increased heart rate.

Overdose

Symptoms when taking an excessive amount of Claritin:

• Drowsiness;
• Apathy and lethargy;
• Cardiopalmus;
• Headache.

To remove excess drug from the stomach, it should be washed out, using absorbent drugs.

Be sure to see a doctor!

Contraindications

• Age up to 2 years (for syrup), because no experimental trials have been conducted on the use of the Claritin allergy remedy in children under 2 years of age
• Age up to 3 years (for tablets);
• lactation period (breastfeeding);
• Rare hereditary diseases (galactose intolerance disorders, lapp lactase deficiency or glucose-galactose malabsorption) - due to the presence of lactose, which is part of the tablets;
• In diseases associated with sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption - due to the presence of sucrose, which is part of the syrup;
• Hypersensitivity to the components of the drug.

Storage conditions

Claritin is stored at an air temperature not higher than 25 degrees, in the original packaging, out of the reach of children. Tablets can be used within 4 years from the date of production, syrup is stored for 3 years.

After opening the syrup, do not use after 28 days.

Price

Average price of Claritin tablets:

• 7 pcs. — 170 -220 rubles;
• 10 pieces. — 230-245 rubles;
• 30 pcs. — 600-670 rubles .

The average price of Claritin in the form of syrup:

• Syrup 60 ml - 260-290 rubles;
• Syrup 120 ml - 370-430 rubles .

Analogues

Possible analogues of Claritin:

• Erius- a long-acting antihistamine drug aimed at eliminating or alleviating sneezing, nasal congestion, mucus discharge from the nose, itchy nose, itchy palate, itching and redness of the eyes, watery eyes;
• Ketotifen— effectively prevents attacks of bronchial asthma, other manifestations of allergic reactions of immediate type;
• Loratadine- is indicated for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children over the age of 2 years weighing more than 30 kg;
• Desloratadine- the drug copes well with seasonal and year-round allergic rhinitis, chronic idiopathic urticaria;
• Diazolin- most often prescribed for combined therapy of itchy dermatoses and bronchial asthma.

What to choose?

When choosing an antihistamine for third-generation allergies, it is necessary to take into account some features of this group:

• The elimination period of most drugs in this group ranges from 12 hours to a month. That is why these drugs can only be prescribed by a doctor.
• Some drugs have a pathological effect on the heart muscle (astemizole), inhibiting its work. There may be tachycardia or interruptions in the work of the heart.

Less toxic and safe drugs from this group can be considered Claritin and Zyrtec. They can be used in both adults and children with minimal side effects.

The pharmacy chain offers a wide range of antiallergic drugs of different generations in different price ranges. It should be understood that any drug is prescribed by a doctor, based on the individual characteristics of the disease.

It is necessary to buy an allergy medicine after an appointment by a specialist and an accurate recommendation on the timing of administration and dosage.

Many buyers are wondering which drug is better to choose? Let's compare some of them.

These allergy remedies are in different generations, respectively, they differ greatly in the direction of action:

• A big plus of Suprastin is the speed of the onset of the effect.- occurs within 10-15 minutes after oral administration. That is why it is effective against acute allergies, for the rapid elimination of symptoms.
• Due to the fact that Suprastin does not act selectively on receptors, the drug has more undesirable effects compared to Claritin.
• Claritin does not cause lethargy or drowsiness- effects characteristic of Suprastin.
• While taking Suprastin from allergies, excessive dryness of the mucous membranes may occur. This can lead to a reflex runny nose, sore throat, and the introduction of bacteria.
• Suprastin has a pronounced bitter taste, so children may not always be able to swallow an allergy pill.

Zyrtec is a second generation antihistamine. A significant difference between the second and third generations of these drugs in the severity of antiallergic action. So, Zyrtec, has a weak activity against allergens and is more suitable for preventing the formation of exacerbations.

Claritin has a more powerful action against the allergen, a small number of side effects and can be used in the acute phase of the disease.

Both Erius and Claritin belong to the third generation of allergy medicines, respectively, and their focus on allergens is the same. There is no significant difference in the mechanism of action or side effects of the drugs.

Differences can only be found in the price range. Therefore, when prescribed by a doctor, you can choose any of the drugs for allergies.

Experienced allergists claim that Erius acts somewhat wider on the allergic spectrum and is quite effective for allergic cough. Therefore, at the initial reception, you can use Erius, and then switch to Claritin.

Tavegil, like Suprastin, belongs to the first generation of histamine receptor blockers, which means it has a pronounced side effect in the form of drowsiness. Therefore, when choosing an allergy medicine for long-term use, it is better to choose Claritin.

Tavegil has the property of drying mucous membranes, especially in children. After treatment with this drug, rhinitis or laryngitis, sometimes bronchitis, may occur.

First-generation histamine receptor blockers are addictive when taken for a long time, which negatively affects patients taking allergy treatment.

Zodak or Claritin?

Zodak in the form of drops has a clear side effect - drowsiness. And also Eliminates allergy symptoms much weaker than Claritin.

Like all second-generation drugs, Zodak has pronounced side effects and weak antiallergic activity.

In pediatric practice, Zodak drops are most often preferred for allergies, because they have a lower dosage than Claritin syrup.

With the ineffectiveness of the first drug, they switch to the second.

As for the use of Claritin and Zodak in adult practice, it is necessary to rely on the recommendations of the doctor and the individual characteristics of the body. Some patients are perfectly helped by Zodak, and some by Claritin.

Manufacturer: Schering-Plough Corp. (Schering-Plough Cor.) USA

ATC code: R06AX13

Farm group:

Release form: Solid dosage forms. Pills.

General characteristics. Compound:

Tablets. The active substance is loratadine 10 mg.

Excipients - lactose monohydrate, corn starch, magnesium stearate.

Syrup. The active substance is loratadine 1 mg/ml.

Excipients - propylene glycol, glycerol, citric acid monohydrate (anhydrous alternative citric acid), sodium benzoate, sucrose (granulated), artificial flavor (peach), purified water.

Pharmacological properties:

Pharmacodynamics. Claritin is an antihistamine drug - a selective blocker of peripheral H1-histamine receptors. Possesses fast and long antiallergic action. The onset of action is within 30 minutes after ingestion. The antihistamine effect reaches a maximum after 8-12 hours from the onset of action and lasts more than 24 hours. Claritin does not penetrate the blood-brain barrier and does not affect the central nervous system, does not have anticholinergic and sedative effects (drowsiness), does not affect the speed of psychomotor reactions. Taking Claritin does not lead to prolongation of the QT interval on the ECG.

Pharmacokinetics. Claritin is rapidly absorbed from the gastrointestinal tract. The time to reach the maximum plasma concentration of loratadine is 1.3 hours, and its active metabolite, desloratadine, is 2.5 hours. Eating increases the time to reach maximum concentration (Tmax) of loratadine and desloratadine by approximately 1 hour. The maximum concentration (Cmax) of loratadine and desloratadine does not depend on food intake. The maximum concentration increases in elderly patients, patients with chronic renal failure or alcoholic liver disease.
Loratadine is metabolized to desloratadine via cytochrome P450 ZA4 and, to a lesser extent, cytochrome P450 2D6. Excreted with urine and bile. The half-life of loratadine is 3 to 20 hours (mean 8.4 hours) and that of desloratadine is 8.8 to 92 hours (mean 28 hours); in elderly patients, respectively, from 6.7 to 37 hours (average 18.2 hours) and from 11 to 39 hours (average 17.5 hours). The half-life increases with alcoholic liver damage (depending on the severity of the disease) and does not change in the presence of.
Conduction had no effect on the pharmacokinetics of loratadine and its active metabolite.

Indications for use:

Seasonal (hay fever) and year-round allergic rhinitis and allergic - elimination of symptoms associated with these diseases - itching of the nasal mucosa, rhinorrhea, burning sensation and itching in the eyes,.
-
- Skin diseases of allergic origin.

Important! Get to know the treatment

Dosage and administration:

Inside, regardless of the meal time.
Adults. including the elderly, and adolescents over the age of 12, it is recommended to take Claritin at a dose of 10 mg (1 tablet or 2 teaspoons (10 ml) of syrup) 1 time per day.
For patients with impaired liver function or renal insufficiency, the initial dose should be 1 tablet (10 mg) or 2 teaspoons (10 ml) of syrup every other day.

For children aged 2 to 12 years, the dose of Claritin is recommended depending on body weight:
- with a body weight of less than 30 kg - 5 mg (1 teaspoon (5 ml) of syrup or 1/2 tablet) 1 time per day.
- with a body weight of 30 kg or more - 10 mg (2 teaspoons (10 ml) of syrup or 1 tablet) 1 time per day.

Application Features:

Children under the age of 3 years are recommended to take Claritin in the form of syrup.
There was no negative effect of Claritin on the ability to drive a car or perform other activities that require increased concentration.

Side effects:

The adverse events listed below occurred with a frequency of > 2% with Claritin and approximately the same frequency as with placebo ("dummy").
In adults, fatigue, dry mouth, drowsiness, gastrointestinal disorders (nausea,), as well as allergic reactions in the form of a rash, were noted. In addition, there have been rare reports of anaphylaxis, liver dysfunction, palpitations,.
In children, headache, nervousness, and sedation were rarely observed. As in adults, the frequency of these events was at the same level as with placebo ("dummy").

Interaction with other drugs:

Eating does not affect the effectiveness of the drug.
Claritin does not increase the effect of alcohol on the central nervous system. When Claritin was co-administered with ketoconazole, erythromycin or cimetidine, an increase in plasma concentrations of loratadine and its metabolite was noted, but this increase did not manifest itself clinically, including according to electrocardiography.

Contraindications:

Intolerance or hypersensitivity to loratadine or any other component of the drug,
- age up to 2 years,
- lactation period.

Carefully.
- pregnancy,
- .

Use during pregnancy and lactation.
The use of Claritin during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.
Claritin is excreted in breast milk, therefore, when prescribing the drug during lactation, the issue of stopping breastfeeding should be resolved.

Overdose:

Symptoms: drowsiness, tachycardia, headache. In case of overdose, you should immediately consult a doctor.
Treatment: (preferably 0.9% sodium chloride solution), intake of adsorbents (crushed activated carbon with water), symptomatic agents.
Loratadine is not excreted by hemodialysis.

Storage conditions:

At a temperature not higher than 25 °C.
In a place inaccessible to children.

Leave conditions:

Over the counter

Package:

Tablets 10 mg: 7, 10 or 15 tablets in blisters made of PVC and aluminum foil. 1, 2 or 3 blisters along with instructions for use in a cardboard box.
Syrup 1 mg / ml: 60 or 120 ml in dark glass bottles, sealed with aluminum screw caps with a protective ring against accidental opening and a polyethylene gasket; 1 bottle complete with a plastic spoon-dispenser and instructions for use in a cardboard box.

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Claritin is a drug that eliminates the manifestations of allergies during attacks. The drug can also be used as a prophylactic to prevent recurrence of chronic diseases, in the pathogenesis of which allergic inflammation plays a leading role (for example, bronchial asthma). Claritin is classified as a selective histamine receptor blocker ( antihistamine), which affect only the cellular structures involved in the allergic reaction, but do not affect other organs. It is due to the selectivity of action on histamine receptors that the drug effectively relieves allergy symptoms, and does not cause drowsiness or dryness of the mucous membranes.

Forms of release, composition and dosage

To date, the drug Claritin is produced by the pharmaceutical corporation SCHERING-PLOUGH LABO N.V. in two dosage forms - syrup and tablets. The syrup is also called children's Claritin, since the drug is intended for the treatment of allergies in a child. Claritin in the form of drops, ointments, or under the name l-Claritin, is not currently produced by official pharmaceutical companies and trademark owners.

Syrup Claritin is a clear solution, uncolored or with a slight yellowish tint, homogeneous, free of impurities or sediment. The drug is available in dark glass bottles of 60 ml and 120 ml, with a measuring spoon in the package.

Claritin tablets are oval-shaped, white-colored, scored on one side, and printed on the other side with an icon in the form of a cup or flask with the number 10. The drug is available in packs of 7, 10, 20 and 30 tablets.

Both tablets and Claritin syrup contain loratadine as an active ingredient. In this case, one tablet contains 10 mg of loratadine, and 1 ml of syrup - 1 mg. Since Claritin is an anti-allergic drug, the drug also contains low-allergenic substances as auxiliary components. Tablets contain corn starch, magnesium stearate and lactose as excipients. And the syrup contains glycerin, propylene glycol, citric acid, sucrose, sodium benzoate and peach synthetic flavor.

Claritin for allergies - therapeutic effects and action

The drug Claritin has anti-allergic, antihistamine and antipruritic effects. These therapeutic effects are due to the fact that Claritin blocks histamine receptors. The effects develop very quickly (within half an hour) after taking the drug, and their duration is up to 24 hours.

An allergic reaction is largely due to a special substance - histamine, which is released from the cells of the body when an allergen enters. Histamine binds to receptors on cells (histamine) and triggers a cascade of reactions that lead to symptoms of an allergic reaction. So histamine increases blood flow, triggers an inflammatory reaction on the skin and mucous membranes, provokes severe itching and other manifestations of allergies, such as snot, nasal congestion, tearing, sneezing, coughing, etc.

Claritin blocks histamine receptors, preventing the development of an allergic reaction. In principle, histamine itself is released under the influence of an allergen that has entered the body, but the receptors of the cells on which it acts are blocked, and the substance simply cannot have its effect. By the time the drug is taken, usually a certain amount of histamine has already bound to its receptors, and the process of an allergic reaction is started. But after taking the medicine, it blocks the remaining receptors, and the allergic reaction cannot continue. As a result, the symptoms that have already developed disappear quickly, since their course and intensification at the cellular level are no longer supported.

The drug Claritin is not able to pass through the blood-brain barrier and bind to histamine receptors located in the central nervous system, so it does not have a sedative effect, expressed in drowsiness. This type of action is called selective, since histamine receptors are located in different tissues, but Claritin only acts on those that are responsible for the development of allergies. Drugs of the past generation (for example, Suprastin or Diphenhydramine) do not have such selectivity of action, which is why they cause drowsiness as a side effect.

Indications for use

Since Claritin is an antiallergic drug, its scope is due to the fight against the symptoms of this pathology.

Indications for the use of the drug are the following conditions:

• seasonal allergic rhinitis (hay fever);
• year-round allergic rhinitis;
• seasonal or year-round allergic conjunctivitis;
• chronic urticaria;
• skin diseases of an allergic nature (for example, dermatitis, eczema, etc.);
• angioedema;
• allergic reaction to bites of various biological objects;
• pseudo-allergic reaction associated with the use of histamine-liberator products (for example, tomatoes, strawberries, chocolate, coffee, cocoa, etc.).

Claritin relieves the symptoms of these allergic pathologies, such as:

• sneezing
• swelling of the mucosa;
• feeling of nasal congestion;
• runny nose;
• lacrimation;
• bronchospasm;
• burning and itching in the eyes, nose and skin;
• rashes.

Claritin - instructions for use: how to take syrup and tablets

Both syrup and Claritin tablets are taken orally at any time, regardless of food intake. The tablet or syrup should be washed down with plain clean water. The dosage is determined by the person's age and comorbidities. Children under 3 years old should be given Claritin in the form of syrup, and over 3 years old - in tablets or syrup, at their own discretion.

Adults and adolescents from the age of 12 take Claritin in the form of tablets at a dosage of 10 mg, once a day. A dose of 10 ml corresponds to one tablet or two measuring spoons of syrup. If a person suffers from liver pathology or kidney failure, then Claritin should be started at a dosage of 10 mg, once every two days - that is, one tablet or two tablespoons of syrup every other day. The use of Claritin 10 mg every other day in renal failure is indicated for a filtration coefficient (CC) of less than 30 ml / min, based on the Reberg test. For this category of patients, you can change the dosage regimen of the drug, and take half a tablet or one spoonful of syrup every day, once a day.

Children aged 2 to 12 years should receive Claritin at an individualized dosage, which depends on body weight. If the weight of the child is less than 30 kg, then the dosage of Claritin is 5 mg (half a tablet) or 5 ml (1 spoonful of syrup), once a day. In this case, it is better to use syrup, since the dosage of the drug will be more accurate than when breaking off half a tablet. If the child's body weight exceeds 30 kg, then the dosage is 10 mg (1 tablet) or 10 ml (2 tablespoons of syrup) once a day.

If it is necessary to carry out skin allergy tests, Claritin should be discontinued at least 2 days before the procedure in order to avoid false negative results.

Overdose the drug is possible when the dose is exceeded by more than 40 mg per day. In this case, the following symptoms develop: headache, drowsiness, palpitations. Children weighing less than 30 kg respond to an overdose of Claritin with palpitations and extrapyramidal symptoms (impaired muscle tone, slow worm-like movements of the fingers, skewed mouth, twitching of the lips, torticollis, tics, trembling, sweeping movements of the limbs, etc.). Treatment is aimed at eliminating symptoms and removing the drug from the body as soon as possible. Excretion of the drug is carried out by gastric lavage with saline and the use of adsorbents (for example, powdered activated carbon with water).

Interaction of Claritin with other drugs. Ketoconazole, erythromycin and cimetidine increase the concentration of Claritin in the blood, but this does not manifest itself clinically. But this circumstance should be borne in mind so as not to get an accidental overdose.

Claritin for children (syrup) - instructions for use

Children can be given the drug from the age of 2 years. A child in the age range of 2 to 3 years should receive Claritin only in the form of syrup. Upon reaching 3 years, the child can take the medicine in both syrup and tablets. That is why the syrup is called children's Claritin.

The main determining factor in the dosage of Claritin in children is body weight. It is important to remember that Claritin is taken in the appropriate dosage once a day, preferably at the same time of the day. For children, there are two doses, depending on the weight of the child:
1. Body weight of a child over 30 kg - Take Claritin 10 mg (2 scoops or teaspoons of syrup or 1 tablet);
2. Body weight of a child less than 30 kg - Claritin take 5 mg (1 scoop or teaspoon or half a tablet). Sometimes the scheme of application is changed, and the child is given 10 mg of Claritin every other day.

The duration of the course of treatment depends on the speed of elimination of symptoms in an acute condition, and can range from several days to 2 weeks. When using Claritin as a prophylactic, you can take the drug for a long time.

Claritin passes into breast milk, where its concentration is the same as in the blood of a woman. Therefore, if it is necessary to use the drug during breastfeeding, breastfeeding should be abandoned and the child should be transferred to artificial mixtures.

Side effects

Claritin has a small number of side effects that differ between adults and children.

Side effects of Claritin in children include the following symptoms:

• lethargy.

In adults, Claritin can provoke the development of the following symptoms as side effects:

• headache;
• drowsiness;
• rash;
• cardiopalmus;
• functional disorders of the liver.

Analogues

Claritin in the domestic pharmaceutical market has not only analogues, but also synonyms. Synonyms are drugs that also contain loratadine as an active ingredient. And analogues are drugs that have the same therapeutic effects as Claritin, but contain another substance as an active ingredient.

So, the following drugs are synonymous with Claritin:

• Tablets Alerpriv;
• Tablets Clallergin;
• Clarifer tablets;
• LoraGeksal tablets;
• Tablets Loratadin Stada;
• Tablets Loratadin-Verte;
• Tablets Loratadin-Teva;
• Tablets Loratadin-OBL;
• Lomilan tablets, lozenges and suspension;
• Syrup and tablets Clargotil;
• Syrup and tablets Claridol;
• Syrup and tablets Clarisence;
• Syrup and tablets Clarotadine;
• Syrup and tablets Loratadine;
• Syrup and tablets Loratadin-Hemofarm;
• Syrup and tablets Erolin;
• Rectal suppositories Lotharen.

Claritin analogues include the following drugs:

• Tablets Allerfeks;
• Tablets Gistafen;
• Gifast tablets;
• Diacin tablets;
• Tablets Dimebon;
• Tablets Dimedrohin;
• Dinox tablets;
• Dramina tablets;
• Ketotifen-Ros tablets;
• Tablets Lordestin;
• Ciel tablets;
• Tablets Telfast;
• Feksadin tablets;
• Fexo tablets;
• Fexofast tablets;
• Desloratadine-Teva tablets;
• Bexist-sanovel tablets;
• Rupafin tablets;
• Fexofenadine tablets;
• Tablets Desloratadine Canon;
• Diazolin tablets with zinc sulfate;
• Dragee and Diazolin tablets;
• Dimedrokhin solution is administered subcutaneously and intramuscularly;
• Syrup and tablets Kestin;
• Syrup and tablets Ketotifen;
• Syrup and tablets Ketotifen Sopharma;
• Syrup and tablets Peritol;
• Syrup and tablets Erius;
• Capsules Rapido;
• Semprex capsules.

Suprastin or Claritin?

Claritin has a selective effect on histamine receptors, therefore it does not cause numerous side effects from the gastrointestinal tract and the central nervous system. And Suprastin does not act selectively, therefore it has a large number of side effects, including on the mucous membranes and the central nervous system. So, Claritin does not cause drowsiness, and Suprastin, on the contrary, leads to lethargy.

In addition, Suprastin strongly dries the mucous membranes, which can cause excessive mucus formation and the appearance of a runny nosedue to the side effect of the drug. Also, bacteria easily attach to dry mucous membranes, invade cells, which leads to the development of an infectious pathology. Claritin does not dry the mucous membranes, so the risk of developing a bacterial infection while using the drug is minimal.

For these reasons, Claritin is undoubtedly the best drug to choose when comparing it with Suprastin. Suprastin is an old drug that has a large number of side effects, and the power of its antiallergic action is exactly the same as compared to Claritin.

Claritin or Zyrtec?

Claritin and Zyrtec are antihistamines of different generations. To understand the essence of the problem, consider the generation of antiallergic antihistamines:

• 1st generation- drugs Tavegil, Suprastin, Fenistil and Diphenhydramine;
• 2nd generation- Zyrtec drug;
• 3rd generation- drugs Claritin, Telfast, Erius.

The first generation of drugs has an excellent anti-allergic effect, which is combined with a strong side effect in the form of drowsiness. The second generation of antihistamines (Zyrtec) has a significantly less drowsiness effect, but also has a weaker antiallergic effect compared to the first generation drugs. But the third generation (Claritin, Telfast, Erius) has a pronounced anti-allergic effect, like the first generation, combined with the almost complete absence of side effects in the form of drowsiness. Based on the foregoing, the effectiveness of Claritin is higher, and the side effects are less than that of Zirtek.

Due to this circumstance, Claritin should be preferred to Zyrtec. However, the drugs contain different active substances, so the effectiveness of their impact also depends on the individual qualities of the organism. Often in practice there are situations when Zirtek helps one person perfectly, and Claritin is completely useless, or exactly the opposite. In view of this state of affairs, if you do not have experience in using antiallergic drugs, then first choose Claritin and try taking it, but if it turns out to be ineffective, switch to Zyrtec.

Erius or Claritin?

Both Claritin and Erius are antiallergic antihistamines of the latest (third) generation. They have approximately the same therapeutic effect and minimal side effect in the form of drowsiness. Therefore, purely theoretically, there is no difference between Claritin and Erius, you can choose any drug that is more suitable for some subjective reasons (for example, the price or reviews of acquaintances, friends, relatives, etc.).

But in practical medicine, it is impossible to average everything, since people's organisms are individual, reactions to medicines, respectively, too. Therefore, Erius can help one person perfectly, and not have a significant effect on another. The same goes for Claritin. That is why the choice of an antihistamine is an individual matter, in which you may have to try several drugs and decide on the best option for you.

However, Erius, according to allergists, has a slightly wider spectrum of action, since it is also active against allergic cough. Therefore, when buying an antihistamine for the first time, it is better to prefer it over Claritin. If Erius turns out to be ineffective, then you can switch to Claritin and evaluate its therapeutic effect. If Claritin helps well, then you can stop on this drug and take it.

Tavegil or Claritin?

The choice between Claritin and Tavegil is better to make in favor of the first, for several reasons. Firstly, Tavegil is a first-generation antihistamine drug that has a high anti-allergic effect, but also causes severe drowsiness as a side effect. And Claritin has the same level of effectiveness as Tavegil, but does not cause severe drowsiness.

Secondly, Tavegil strongly dries the mucous membranes of the nose, mouth, larynx, bronchi, trachea and even intestines, which causes a number of negative effects. Most often, the dryness of the mucous membranes of the airways leads to easy penetration into the cells of bacteria, and the development of an infectious disease. That is, a person gets rid of allergies, but often gets sick with bronchitis or infectious laryngitis, rhinitis, etc. This side effect is especially pronounced in children. But Claritin does not have the ability to dry the mucous membranes - therefore, the risk of developing an infection is not higher than usual.

Thirdly, first-generation drugs, including Tavegil, cause fairly rapid addiction, the rate of which is determined by the individual characteristics of the organism. In some cases, addiction to Tavegil is formed literally within two to three days, after which the drug becomes completely ineffective. In relation to Claritin, addiction can also develop, but much more slowly and not so strong. This means that even with the development of addiction to Claritin, the drug continues to act - just the anti-allergic effect becomes less pronounced. It is because of the foregoing that it is better to use Claritin, and not Tavegil.

Zodak or Claritin?

Zodak drops are a second-generation antihistamine, unlike Claritin, which belongs to the third. The second generation of antihistamines has a less pronounced antiallergic effect, compared with the representatives of the third. In addition, the Zodak is characterized by a greater severity of the side effect in the form of drowsiness, compared with Claritin. For these reasons, it is better to focus on Claritin.

However, in the practice of pediatricians, the Zodak drug in drops is often better for children than Claritin. Zodak has a lower dosage, and it should also be taken once a day. Therefore, if you choose a drug for a child, it is better to try the Zodak first. If the Zodak turns out to be ineffective, you can safely switch to Claritin, which has a more pronounced therapeutic effect.

In a situation with adults, allergists recommend Claritin, which has a stronger antiallergic effect than Zodak. But since people are individual, Zodak can help some people, and Claritin, on the contrary, does not have any effect. Therefore, the choice of drug should be made individually. Allergist recommendations regarding the benefits of Claritin over Zodak in adults can only be used with the first use of an antihistamine. And later, if Claritin was effective, then you should buy it. If the drug did not have a good effect, then you can change it to the Zodak, then, comparing the effectiveness, choose the best remedy for you.

Claritin: instructions for use and reviews

Claritin is an antiallergic agent, a blocker of histamine H 1 receptors.

Release form and composition

Dosage forms of Claritin:

• Tablets: oval-shaped with a homogeneous structure of white or almost white color, on the side with a dividing risk the number "10" and the trade mark "Cup and flask" are applied, the second side is smooth (7, 10 or 15 pieces in blisters, in a cardboard box 1, 2 or 3 blisters);
• Syrup: transparent yellowish or colorless liquid without visible particles (60 or 120 ml in dark glass bottles, in a carton box 1 bottle complete with a dosing spoon or a 5 ml graduated syringe).

The active substance is loratadine:

• 1 tablet - 10 mg;
• 1 ml of syrup - 1 mg.

Auxiliary components:

• Tablets: corn starch, lactose monohydrate, magnesium stearate;
• Syrup: glycerol, propylene glycol, artificial flavor (peach), citric acid monohydrate (or anhydrous citric acid), sucrose (granulated), sodium benzoate, purified water.

Pharmacological properties

Claritin is characterized by antiallergic, antihistamine and antipruritic properties.

Pharmacodynamics

Loratadine is a tricyclic compound with a pronounced antihistamine effect, and is a selective blocker of peripheral H 1 -histamine receptors. The anti-allergic effect occurs soon after ingestion and lasts a long time. Loratadine begins to act within 30 minutes after oral administration of the drug. The peak phase of the antihistamine effect is observed 8-12 hours after the onset of the drug and lasts more than 1 day.

Loratadine does not cross the blood-brain barrier and does not affect the functioning of the central nervous system (central nervous system). During its administration, no sedative or anticholinergic effect of clinical significance was detected, therefore the drug does not provoke drowsiness and does not reduce the speed of psychomotor reactions when used in therapeutic doses. Taking Claritin does not cause a prolongation of the QT interval on the ECG.

Long-term therapy was not accompanied by changes in vital signs, electrocardiography, laboratory data, or physical examination results of clinical significance. Loratadine is not characterized by significant selectivity for H 2 -histamine receptors. The substance is not a norepinephrine reuptake inhibitor and has little or no effect on pacemaker function or cardiovascular health.

Pharmacokinetics

Loratadine is well and rapidly absorbed from the gastrointestinal tract. Its maximum plasma concentration is determined 1-1.5 hours after administration, and the maximum concentration of its pharmacologically active metabolite desloratadine is 1.5-3.7 hours. When taking Claritin with food, the time to reach the maximum concentration of loratadine and its metabolite increases by about 1 hour, but the bioavailability of the drug does not change. The maximum level of loratadine and desloratadine in the blood does not depend on food intake.

In patients with chronic renal dysfunction, the area under the concentration-time curve (AUC) and the maximum concentration of loratadine and its main metabolite are increased compared with patients with normal renal function. At the same time, the half-lives of loratadine and desloratadine are identical to those in healthy patients. In patients with alcoholic liver disease, the maximum concentration and AUC of loratadine and desloratadine increase by 2 times compared with those in patients with normal liver function.

Loratadine is highly bound to plasma proteins (97-99%), while its metabolite exhibits a moderate degree of binding (73-76%).

In the process of metabolism, loratadine passes into desloratadine using the cytochrome P450 3A4 system and, to a lesser extent, the cytochrome P450 2D6 system. Its excretion is through the kidneys (approximately 40% of the oral dose) and through the intestines (approximately 42% of the oral dose) for more than 10 days, mainly in the form of conjugated metabolites. Approximately 27% of a dose of loratadine is excreted in the urine within 24 hours of taking Claritin. Less than 1% of loratadine is excreted in the urine unchanged within 24 hours after taking the drug.

The bioavailability of loratadine and desloratadine is directly proportional to the oral dose of Claritin. Their pharmacokinetic profiles in adults and elderly volunteers in good health were almost similar.

The half-life of loratadine is 3-20 hours (mean 8.4 hours). This indicator for desloratadine is 8.8-92 hours (mean 28 hours). In elderly patients, the half-life for the active substance Claritin and its metabolite is 6.7-37 hours (mean 18.2 hours) and 11-39 hours (mean 17.5 hours), respectively. This indicator increases with alcoholic liver damage (determined by the severity of the disease) and remains unchanged in patients with chronic renal failure.

The hemodialysis procedure, which is performed in patients with renal dysfunction, does not affect the pharmacokinetic parameters of loratadine and desloratadine.

Indications for use

• Elimination of symptoms associated with year-round and seasonal allergic rhinoconjunctivitis (itching of the nasal mucosa, sneezing, rhinorrhea, lacrimation, itching and burning sensation in the eyes);
• Skin diseases of allergic origin;
• Chronic idiopathic urticaria.

Contraindications

• The period of breastfeeding;
• Hypersensitivity to the components of the drug.

In addition, the use of Claritin is contraindicated:

• Tablets: lactase deficiency or glucose-galactose malabsorption, impaired galactose tolerance; age up to 3 years;
• Syrup: sucrase or isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption; age up to 2 years.

Instructions for use Claritin: method and dosage

Syrup and Claritin tablets are taken orally 1 time per day at any convenient time, regardless of food intake.

• Patients over 12 years old: 10 mg (1 tablet or 10 ml of syrup);
• Children from 2 to 12 years old: with a weight of up to 30 kg - 5 mg each (1/2 tablet or 5 ml of syrup), with a weight of 30 kg and above - 10 mg each.

For patients (adults and children) with severe liver dysfunction, the drug is prescribed every other day in the usual doses.

In chronic renal failure and in elderly patients, dose adjustment of Claritin is not required.

Side effects

According to the instructions, Claritin can cause side effects:

• From the nervous system: nervousness (in children), drowsiness, headache, insomnia; very rarely - fatigue, dizziness;
• From the side of the cardiovascular system: very rarely - tachycardia, palpitations;
• From the digestive system: increased appetite (in adults); very rarely - gastrointestinal disorders (nausea, gastritis), dry mouth, impaired liver function;
• On the part of the skin: very rarely - alopecia;
• Allergic reactions: very rarely - anaphylaxis, rash.

Overdose

An overdose of Claritin can be suspected by symptoms such as headache, tachycardia, and drowsiness. In this case, you should immediately consult a doctor. Treatment is usually supportive and symptomatic therapy. It is allowed to wash the stomach and take adsorbents (activated carbon in crushed form is mixed with water).

Loratadine is not excreted by hemodialysis. After providing emergency care, it is necessary to monitor the patient's condition.

special instructions

Antihistamines can distort the results of skin tests, so it is recommended to stop taking Claritin 48 hours before diagnostic skin tests.

Since in some patients the action of the drug can cause a state of drowsiness, it is recommended that during therapy be careful when driving vehicles and mechanisms.

Use during pregnancy and lactation

The safety of taking loratadine during pregnancy has not yet been fully confirmed. Therefore, the use of Claritin is possible only if the probable benefit of treatment for the mother outweighs the potential risks to the fetus.

Loratadine and desloratadine pass into breast milk, therefore, when prescribing the drug during lactation, it is necessary to stop breastfeeding.

For impaired renal function

For patients with renal insufficiency, the initial dose should be 10 mg every other day.

For impaired liver function

In patients with hepatic insufficiency, the initial dose of the drug should not exceed 10 mg every other day.

drug interaction

With simultaneous use, the action of Claritin does not increase the effect of alcohol on the nervous system.

When Claritin is combined with erythromycin, ketoconazole or cimetidine, there is a slight increase in the plasma concentration of loratadine, but it has no clinical consequences, including also electrocardiographic data.

Analogues

Analogues of Claritin are: Loratadin, Loratadin-Akrikhin, Loragexal, Lomilan, Clarotadin, Claridol, Lotharen, Clarisens, Clarifer, Klarfast, Klarifarm, Kllergin, Klargotil, Alerpriv, Erolin, Erius.

Terms and conditions of storage

Store below 25°C. Keep away from children.

Shelf life: tablets - 4 years, syrup - 3 years.

Various negative factors (pollen, smells, wool, fragrances, food, etc.) can affect the body. The environment is getting dirtier, people's immunity is noticeably weakening. With this in mind, the frequency of manifestations of allergies is increasing.

There are a lot of remedies that can eliminate this problem, but they have a different effect on different organisms. The medicine must be selected taking into account the factor that caused the violation in the body, the individuality of each organism.

In some cases, Claritin is prescribed. It belongs to antihistamines. Apply it for systemic use. The code of the drug we are considering is ATX R06A X13.

Composition, release form, packaging

Loratadine is considered the active ingredient. One tablet contains 10 mg. Let's highlight the following auxiliary components:

• magnesium stearate;
• corn starch;
• lactose monohydrate.

Produced in the form of tablets. They are oval and white in color. The number "10" is applied to one of the sides, and the sign "flasks and bowls" is applied to the other. Contained in a carton pack of 7, 10 tablets in a blister.

You can also purchase this drug in the form of a syrup; in this form of the drug, loratadine also acts as an active ingredient. This tool has many components:

• sodium benzoate;
• glycerol;
• propylene glycol;
• citric acid monohydrate;
• sucrose;
• purified water;
• artificial fragrance.

The composition of the syrup contains no visible particles, it is transparent, may be colorless, slightly yellowish. It is placed inside the bottle, the volume of which can be 60, 120 ml. The ampoules are placed inside a carton.

Manufacturer

The manufacturer of this medication is SHERING-PLOW LABO. Released by Germany.

Indications for use

Assign in case of manifestation:

• seasonal/year-round rhinitis;
• perennial/allergic conjunctivitis; reactions to bites;

It is prescribed in case of manifestation of certain signs (sneezing, burning, rhinorrhea, lacrimation, itching in the eyes).

Contraindications

• children's age (up to 2 years);
• breast-feeding;
• component intolerance.

Mechanism of action

The studied H1-receptor blocker shows its effect after 1-3 hours. The maximum effect is noted at 8 - 12 hours after use, it lasts throughout the day. The development of resistance to Claritin is not observed even when it is used for 28 days. Absorption takes place in the gastrointestinal tract.

Metabolism of the main substance to desloratadine is carried out by the CYP3A4 enzyme. It is excreted in the composition of bile, feces, urine, this period lasts 3 - 20 hours, on average - 8 hours.

Instructions for use

It must be taken internally. Food intake does not play a special role in the manifestation of the medicinal effect. For patients who are over 12 years of age, the recommended dose is 10 mg. This equals one tablet, two drops of syrup per day.

Acceptance by children from two years old is acceptable. In this case, a syrup is prescribed. From the age of three, the use of tablets is allowed. The daily dose is calculated taking into account the weight of the patient. If the weight is less than 30 kg, 5 ml of syrup is prescribed, it should be taken once a day. If the weight is over 30 kg, the norm is 10 mg (2 tsp / 1 tablet).

If a patient with 30 kg. (adult, child) there are severe violations of liver function, he is prescribed initially 10 mg, the medicine is taken every other day. When weighing less than 30 kg. in such a patient, the initial dose is 5 mg, it should be taken every other day.

Side effects

In addition to therapeutic effects, the drug can also cause side effects.

Consider the main ones, which are manifested in:

• CNS (drowsiness, dry mouth, sedation, nervousness);
• allergic reactions (, anaphylaxis);
• digestive system (gastritis, liver dysfunction);
• cardiovascular system ( , );
• alopecia.

Overdose

Overdose symptoms usually appear in:

• tachycardia;
• drowsiness.

To eliminate the manifestations of an overdose, you should contact a specialist. Usually helps gastric lavage, the use of symptomatic drugs, adsorbents.

special instructions

Pregnant women are prescribed only in case of emergency. According to studies (they were performed on animals), no definite effect on the fetus was found. The main component penetrates easily into breast milk, as well as its metabolite. Therefore, it is worth interrupting breastfeeding the baby for the duration of the therapy.

Experts did not find certain data that would relate to the effectiveness, safety of the drug. Therefore, it is prescribed after reaching 2 years of age.

drug interaction

With simultaneous use with cimetidine, ketoconazole, erythromycin, an increase in the plasma concentration of loratadine occurs. At the same time, no clinically significant changes were noted during electrocardiography.

When used, there is no increase in the effect of alcohol on the central nervous system.

Drops reviews

Most people who have used this tool consider it very effective, because it did an excellent job of eliminating various signs of allergies.

Many noted the speed of its action, which in many cases is very important (, Quincke's edema). Some patients have left 100% positive feedback about it as an emergency aid.. A very impressive drawback is the cost of the drug.

Negative reviews were left by some of the sick due to the ineffectiveness of the medication. In certain cases, the drug did not help eliminate. This is due to individual characteristics. Therefore, the use of the drug is recommended only after consultation with an allergist.

Annotation and instructions for the drug Claritin:

Prices for Claritin

The price of the drug differs depending on the form of release, volume:

• tablets (7 pieces per pack) cost between 165 and 210 rubles;
• tablets (10 pieces per pack) - within 230 - 245 rubles;
• tablets (30 pieces per pack) - within 595 - 665 rubles;
• syrup (60 ml.) - 260 - 290 rubles;
• syrup (120 ml.) - 365 - 425 rubles.

Analogues

The agent under consideration has analogues (drugs that exhibit similar therapeutic effects, but at the same time, their active substance is different). Among the analogues, we note tablets:

• "Diacin".
• Allerfex.
• "Dimedrohin".
• Desloratadine-Teva.
• Telfast.
• "Histaphen".
• "Dramina".
• "Fexadin".
• Rupafin.
• "Fexo".
• "Bexist-sanovel".
• "Ciel".
• "Dimedrohin".
• Desloratadine Canon.
• "Erius".
• Ketotifen Sopharma.

Of the syrups, analogues are:

• "Peritol".
• "Kestin".
• "Semprex".
• "Erius".
• Ketotifen Sopharma.
• "Rapido".
• "Ketotifen".

Claritin's analogs

Cheap analogues

Among the cheapest analogues, we indicate the following tablets:

• "Agistam". The cost is about 32 - 40 rubles.
• "". The cost is about 18 - 21 rubles.
• "Vertex Loratadin-verte". The cost is about 20 rubles.

Drug synonyms

You can also use different synonyms. Among the tablets are:

• "Loratadin Stada".
• Alerpriv.
• "LoraHexal".
• "Loratadin".
• "Clarothadine".
• "Loratadin-Teva".
• "Clallergin".
• "Klargotil".
• "Lomilan".
• "Loratadine-OBL".
• "Claridol".
• "Clarices".
• "Clarifer".
• "Erolyn".
• Loratadin-Hemofarm.

Among syrups, synonyms are:

• "Klargotil".
• Loratadin-Hemofarm.
• "Clarothadine".
• "Erolyn".
• "Clarices".
• "Claridol".
• "Loratadin".

Which is better: Claritin or? Answer in our video:

Terms of dispensing from pharmacies

Claritin can be bought without a prescription.

Storage and shelf life