Linden for the endometrium. How to increase the thickness of the endometrium

Thin endometrium- is one of the reasons preventing natural conception. Its thickness is determined by several factors, including hormonal changes. It becomes most functional in the premenstrual period. The question of how to build up the endometrium is most relevant for women planning to become mothers.

The structure and functions of the endometrium

endometrium- mucous membrane of the uterine cavity. How quickly and successfully the fertilized can gain a foothold depends on its thickness, integrity and functionality.

The structure of the endometrium includes:

• epithelium - the cell layer lining the uterine cavity;
• capillaries, glandular ducts;
• stroma - the supporting connective tissue that produces collagen during menstruation.

The main function of the endometrium is to create conditions favorable for fixation and normal development embryo in the uterine cavity. Normally, after the mucous membrane begins to change: its blood supply and secretory functions increase. In the future, the vessels of the endometrium take part in. Thanks to them developing fetus in the right measure receives oxygen and all the substances necessary for development.

Another function of the endometrium is a barrier. It prevents the development of adhesions: it does not allow the walls of the uterus to stick together, despite their constant contact.

The probability of pregnancy depends on the thickness and structure of the endometrium, as well as on the maturity of the glandular layer. The functionality of the mucous membrane is determined by the presence of estradiol, a hormone produced by the follicles. For him, the maturation of the endometrium and the further production of progesterone occur.

Causes of insufficient thickness of the endometrium

In order to determine how to quickly build up the endometrium for successful conception, you need to find out the reasons for its reduced functionality. A thin lining of the uterus may be due to the following factors:

• pathology endocrine system present from birth;
• dysfunction in the production of glands internal secretion, leading to a discrepancy between the level of hormones period menstrual cycle;
• insufficient blood supply to the uterus, Bladder, muscles of the pelvic floor and rectum, as a result of inflammation, operations, injuries, as well as congenital nature;
• damage to the mucous layer of the uterus, most often resulting from abortion and curettage;
• underdevelopment of the muscles of the pelvic floor and uterus;
• infectious diseases of the uterus;
• use of birth control pills.

Currently, researchers are suggesting that heredity may be the cause of insufficient mucosal thickness. But there is not enough clinical data to support this theory.

Thin endometrium

Enlargement of the endometrium with medication

To build up the endometrium short time medicines must be used. Their appointment should be dealt with exclusively by a doctor, since only he will be able to choose the most effective drugs and develop a proper treatment plan.

Since the build-up of the endometrium occurs by increasing the amount of estradiol, hormonal drugs can quickly cope with the task. The scheme of their reception is determined by the phases of the cycle.

In the first half, injections of Divigel, Estradiol, Femoston and Proginova tablets are prescribed. These medicines increase endometrial thickness, increasing blood circulation and activity of the glands.

In the second phase, Duphaston and Utrozhestan are required. These drugs contribute to the formation and maturation of the endometrium. Both contain a large number of progesterone - a hormone necessary for fixing the embryo in the uterine cavity and a successful pregnancy.

In addition to hormonal drugs, the doctor may prescribe medications necessary to treat diseases that are the causes of thin endometrium. The main objectives of such therapy are the restoration of the damaged mucous membrane, the elimination of infectious and inflammatory processes in the uterus. If a woman takes birth control pills, they will need to be cancelled.

Building up the endometrium with folk remedies

Thin endometrium is a solvable problem, since it can be increased by using drugs in combination with traditional medicine methods. Among the concoctions medicinal herbs the following are most effective:

• Sage decoction. Phytohormones increase the level of estrogen in the blood and stimulate the activity of the follicles. To prepare a decoction, you need 1 tbsp. l. dried crushed plant pour 250 ml of water, boil and cool for 10-15 minutes. Take a third of the volume up to 4 times a day. Treatment should be carried out according to the menstrual cycle: start from the 4th day of menstruation, end on the day;
• Decoctions of the red brush and boron uterus. These medicinal plants affect the hormonal background, have anti-inflammatory properties. The red brush must be taken in the first half of the cycle, starting on the last day of menstruation. Upland uterus - in the second half of the cycle. Decoction recipe: 1 tbsp. l. pour dry grass into a container, pour 250 ml of boiling water and wrap for 3 hours. Drink 100 ml 3 times a day;
• Knotweed decoction. The drink improves the blood supply to the uterus, helps to restore the mucous membrane. To prepare a decoction glass dried herb you need to pour a liter of boiling water and insist for 5 minutes. Drink 1-2 glasses a day, replacing tea.

Important! Use of any herbal decoction must be agreed with the doctor. Folk recipes can significantly affect the hormonal background, work individual bodies and the state of the organism as a whole.

Lifestyle for Endometrial Buildup

No matter how carefully all the doctor's prescriptions are followed, it is possible to increase the endometrium for conception only with integrated approach. An important role is played by the lifestyle that a woman leads. Proper nutrition and sufficient physical activity are conditions for the health of the body in general and the reproductive system in particular.

A balanced diet helps maintain endometrial thickness and functionality. For successful conception, a woman's daily diet should include:

• sources of vitamin E: leafy vegetables, unrefined grains, bran, vegetable oils;
• sources of vitamin C: blackcurrant, lemons, bell pepper, grapefruit, kiwi;
• sources of salicylates(substances that prevent the formation of blood clots): strawberries, raspberries, honey, raisins, prunes, thyme, curry, paprika, ginger, cinnamon;
• sources of omega-3 fatty acids: rapeseed and linseed oil, tuna, nuts, salmon.

With insufficient blood supply to the pelvic organs, moderate physical activity is necessary. Swimming, running, fitness, as well as oriental dancing can contribute to the thickening of the mucous membrane. Exist special exercises leading to the strengthening of the muscles of the perineum and small pelvis (Kegel technique, wumbling). But before starting classes, it is worth consulting with a doctor, in some cases physical exercise may aggravate the situation.

The doctor can give an exact answer to the question of how to build up the endometrium. He will spend everything necessary examinations and based on the results obtained will create an effective treatment program. Modern approach to restore the functions of the uterine mucosa includes the use of drugs, folk remedies, as well as compliance with the rules of nutrition and physical activity.

The endometrium performs a complex function - an egg is embedded in it and divides over several weeks. The inner layer of the uterine cavity plays the role of an early "placenta" for germ cells and provides nutrition, protection, and blood supply. Therefore, before pregnancy, it is necessary to prepare the maturation of a healthy endometrium. If there are problems with the reproductive system, this can be done using hormone therapy, folk remedies. For healthy women, methods such as taking vitamins and including healthy foods in the diet are suitable.

Causes of endometrial growth disorder

The endometrium lines the inner lining of the uterine cavity, which is shed in women during the menstrual cycle. The formation of its cells depends on the effects of hormones produced in the ovaries.

The growth of the uterine epithelium is necessary for the implantation of a fertilized egg. In the first weeks of pregnancy, the endometrium performs a nutritional function, due to which it divides and increases in size.

Estrogen regulates the growth of the endometrium, preparing it for the implantation of an egg. In the female body, this hormone is contained in the follicles that are formed in the ovaries under the influence of the regulation of the central nervous system.

In the second phase of the cycle healthy woman dominated by progesterone. It contributes to vascular thrombosis in the thickness of the uterus, resulting in rejection of the endometrium and menstrual bleeding develops.

Growth of the endometrium under the influence of hormones in the menstrual phase

Main reasons dystrophic changes epithelial layer of the uterus:

• Curettage during abortion or surgery.
• Hormonal imbalance against the background of inflammatory changes in the genital organs.
• Taking oral contraceptives or using an intrauterine device.
• Hormone-producing tumors that produce large amounts of progesterone.

Treatment

The main goal of therapy is to prepare a woman's body for conception or for IVF (in vitro fertilization). For treatment, medications and folk remedies are used. A beneficial effect is provided by the intake of vitamins and the use of certain foods.

Medicines

The drugs help to quickly build up the endometrium, as they contain a large amount of estrogen. The following medicines are actively used:

• Divigel;
• Utrozhestan;
• Proginova;
• Curantyl.

Divigel

Divigel comes in the form of a gel that is applied to the skin. Contains estradiol, carbomer, ethinol and propylene glycol. The composition includes alcohol, in which it dissolves well active ingredient. This facilitates the penetration of the drug into the blood.

The drug has a powerful estrogenic effect due to the high content of estradiol, a substance that, in chemical and biological properties, resembles a woman's own hormone.

Estradiol penetrates through the cell membrane into the nucleus of the uterine epitheliocyte and binds to specific receptors. After that, a ligand-complex is formed, which enhances the formation of nucleic acids, stimulates the growth blood vessels and activates the work of the genome.

Actions of the drug:

• Promotes the development of the endometrium (including reduces the activity of the mammary glands, which leads to inhibition of the formation breast milk and is additional factor growth).
• Prevents the formation of a deficiency of sex hormones.
• Stimulates and accelerates healing connective tissue after surgery or abortion.
• Helps in establishing a regular menstrual cycle.

You can not use the drug in the following conditions:

• allergy to estradiol;
• cancer of the breast and other genital organs;
• uterine bleeding;
• brain tumors.

Divigel is prescribed only by an obstetrician-gynecologist after a thorough examination and study of the content of hormones in the blood.

Side effects:

• headache;
• dizziness;
• chorea (chaotic movements of the arms and legs);
• inflammation of the vein wall;
• increase in pressure;
• vomiting or bloating in case of overdose.

If these symptoms occur, you should consult a doctor.

Utrozhestan

Utrozhestan is available in the form of capsules and tablets that contain the hormone progesterone. This hormone is produced in the second phase of the menstrual cycle and is responsible for the growth, thickening and strengthening of the membrane. inner surface uterus. Progesterone promotes conception and pregnancy.

In women with endometrial growth disorder, Utrozhestan is used in combination with estrogenic drugs.

When taking capsules, the hormone is absorbed by the oral mucosa and circulates in the blood for up to 4-6 hours. Excreted in the urine, does not accumulate in the body.

Medication actions:

1. 1. Promotes the correct implantation of the embryo.
2. 2. Helps to get rid of infertility, restores the menstrual cycle.
3. 3. Treats menopausal conditions and luteal insufficiency.
4. 4. With IVF, it helps to prolong the 2nd phase of the cycle, in which there is an increase in activity corpus luteum and growth of the endometrium.
5. 5. Helps cure endocrine infertility (lack of hormones in the ovaries) and endometriosis.

The course of treatment depends on the pathology that caused the pills to be taken. On average, it lasts from 12 to 20 days per month. The dosage is set by the doctor according to the instructions and the initial level of hormones. In case of overdose or misuse develops urticaria, drowsiness.

Contraindications for the appointment of Utrozhestan:

• thrombophlebitis;
• hereditary porphyria;
• liver and kidney failure;
• ischemic disorders;
• incomplete abortion.

Adverse reactions develop in the form of:

• headache;
• total absence menstrual bleeding within 2 cycles;
• bleeding in the middle of the cycle.

Some women develop acne on the face, vomiting, constipation, drowsiness and itchy skin. In this case, it is recommended to cancel the drug.

Utrozhestan should not be used simultaneously with drugs that inhibit liver enzymes. These include rifampicin, spironolactone, barbiturates, and antibiotics. With the joint introduction of these drugs, toxic damage to the liver occurs.

Proginova

Proginova contains a large amount of estradiol valerate, which compensates for the lack of its own estrogen in a woman's body. Valerate is a structural analogue of the hormone, so its main function is to stimulate ovulation.

The drug is absorbed in the oral mucosa, enters the bloodstream and is sent to the liver. Here the transformation reaction takes place, where from valerate is formed active substance.

Indications for prescribing the remedy:

Indications	effect fromdrug
Menopause	Prevention of osteoporosis. In the absence of estrogen in the body, the structure of the bones changes, which leads to their fragility. Proginova prevents the formation of bone pathology. Relief of manifestations of menopause. The drug eliminates the symptoms observed in women during menopause: pain during urination, fungal infections skin in the genital area and irritation of the skin of the perineum. Restoration of hormonal balance. Prevention of endometriosis. Increasing the elasticity of the skin
Amenorrhea	Restoration of the menstrual cycle
Ovarian dysfunction	Replacement of endogenous hormones
Prevention of complications after an abortion	Prevention of bleeding, tumors, cancer

When planning a pregnancy, Proginova is prescribed to increase the layer of the endometrium.

The medicine should be drunk on the first day of the cycle, the course of treatment depends on clinical manifestations. Lasts from 15 to 25 days.

• bleeding from the genitals;
• thrombophlebitis;
• hormonal tumors;
• liver pathology.

Contraindications also include breast-feeding and the age of the patient is less than 18 years. Before use, pregnancy should be excluded, since Proginova can lead to miscarriage.

When taking this drug, the following side effects are likely:

• nausea;
• skin itching;
• flatulence;
• allergy;
• swelling;
• increased heart rate.

If any of the above symptoms occur, you must stop taking the medicine.

Curantyl

Curantil is an angioprotective drug. It is used in all areas of medicine; in gynecology, the remedy is prescribed to patients with a complicated pregnancy. As part of complex therapy the drug is also used to build up a small layer of the endometrium.

The drug contains dipyridamole, it belongs to vasodilators (substances that expand the walls of blood vessels). The drug helps to reduce the formation of blood clots and improves tissue microcirculation. Vasodilation is observed with the introduction of small doses of the drug. Curantyl acts on small-caliber vessels in the uterus.

Curantyl is used in the following cases:

• In order to maintain pregnancy in women with placental insufficiency.
• When planning pregnancy to increase the layer of the endometrium.
• To accelerate the formation of small blood vessels in the thickness of the myometrium and eliminate the phenomenon of fetal hypoxia.
• To eliminate gestosis and eclampsia in women in position.
• In order to prevent the development of malnutrition in newborns.

Curantyl tablets should be taken 2 times a day for a week. In case of emergency pathology of pregnant women, Curantyl is administered intravenously under the control of cardiac performance. Dosage selection is carried out by a doctor. Overdose is accompanied by loss of consciousness, convulsive syndrome, profuse vomiting or an attack of angina pectoris.

• violations of the heart;
• atherosclerosis;
• ischemia;
• diathesis;
• lung pathologies.

Adverse reactions are manifested by tachycardia, skin flushing, lowering blood pressure and dizziness. If the above signs are found, the administration of the drug should be stopped immediately.

Vitamins for the endometrium

They are natural antioxidants and affect many processes in the body:

1. 1. Vitamin E increases the amount small vessels in the inner lining of the uterus, which leads to an increase in the thickness of its layer.
2. 2. Vitamin C can boost immune defense organism and increases the content of growth factors in the blood. They are also actively involved in the formation epithelial cells uterine cavity.

These vitamins are part of the following drugs:

• Elevit Pronatal;Preparation method:

  Herbal collection of elder, drop cap, yarrow, chamomile, mint, coltsfoot, nettle is actively used at home. Herbs help grow the endometrium along with medicines. Also, the collection can prepare for pregnancy a woman who does not have deviations in the menstrual cycle. Plants can improve the quality of the endometrium, which contributes to the birth of a healthy baby.

  Cooking method:

  1. 1. Pour 100 grams of a mixture of herbs with boiling water.
  2. 2. Drink instead of tea 2-3 times a day.

  Healthy foods

  Experts talk about the benefits of pineapple - it contains activators hormonal system and a large amount of vitamin C. After eating this fruit, an increase in blood vessels in the thickness of the uterus is noted, the maturation of follicles in the ovaries begins.

  Eating pineapples is allowed daily, starting a few days before the expected ovulation.

  Useful foods rich in vitamins C and salicylates are blueberries, raisins, cranberries. Eating 100 grams of these berries daily promotes the growth of the endometrium.

  Every day you should eat 400 grams of fresh vegetables and fruits.

Content

The problem of "immaturity" or hypoplasia of the endometrium is especially acute when planning a pregnancy. Insufficient thickness of the endometrium may be the result, on the one hand, of general disorders: insufficiency of estrogen production, low level blood supply in the branches of the arteries of the uterus, pathology of blood clotting, on the other hand, local changes in the inner uterine layer - receptor, immunological. In order to increase the thickness of the endometrium, a thorough diagnosis and search for the causes of hypoplasia is required to select the right treatment tactics.

The main manifestations of the "thin" endometrium in women are irregular scanty menstruation, infertility, early miscarriages. At the heart of the pathogenesis of insufficient thickness of the inner layer of the uterus are various violations circulation, hormonal imbalance with a pronounced lack of estrogen, immunological disorders. In addition, a history of curettage is also common cause growth disorders of the endometrial layer. When cleaning, damage to the germ layer of the uterus is not excluded, in such situations it develops absolute infertility, since it is this layer that is the source of growth of the functional endometrium.

The process of increasing the thickness of the endometrial layer is aimed at normalizing blood flow, hormonal regulation and suppressing infectious and inflammatory processes.

The minimum thickness of the endometrium, required for successful embryo implantation is 8 mm. The onset of pregnancy with indicators of 6-7 mm is possible, but rarely occurs and may result in spontaneous miscarriage due to the defective structure of the layer and insufficient levels of estradiol.

Diagnostics

Diagnostic measures for insufficient thickness of the endometrium are reduced to the determination of the following indicators:

• thickness of the inner uterine layer on ultrasound;
• dopplerometry of the pelvic organs, in particular, the uterine arteries;
• blood test for sex hormones;
• determination of the functioning of the thyroid gland;
• assessment of blood coagulation parameters (extended hemostasiogram);
• thrombophilia testing, antiphospholipid syndrome, hemostasis mutations;
• determination of the level of homocysteine ​​in the blood;
• detection of antibodies to hCG in the blood;
• ) for the purpose of immunohistochemical research, determination of the presence of endometritis;
• hysteroscopy.

Equally important is the examination of the patient for STIs, vaginal dysbiosis. Often, washings of the uterine cavity are taken for examination to exclude infections.

Examination of a woman with suspected endometrial hypoplasia should begin with ultrasound in various days menstrual cycle. The physiological cycle during normal hormonal regulation consists of two phases, the sizes of the uterine inner layer in which are different. To determine the thickness of the endometrium, ultrasound is performed 2-3 times a month. During the first days of the cycle normal sizes vary from 5 to 9 mm, and closer to the day of the expected ovulation, the thickness of the inner uterine layer reaches 10-13 mm. The final ultrasound is performed a week after ovulation to verify the chances of embryo implantation.

The thickness of the endometrium in the first phase of the cycle, equal to less than 6 mm, gives reason to suspect hypoplasia. As a rule, in women with insufficient sizes of the inner uterine layer, deviations in indicators are observed throughout the entire menstrual cycle.

Important in the diagnosis of insufficient thickness of the endometrium is the assessment of blood flow in the uterus. With hypoplasia of the inner layer, insufficient blood flow indicators are often determined, which can be caused by pathology of blood clotting, varicose veins, thrombophlebitis, congenital or acquired vascular anomalies, mechanical factors(compression by a cyst, tumor).

After performing an ultrasound examination, the patient must take a blood test for the content of sex hormones. In the first days of the cycle (on day 2-5), the level of estradiol, follicle-stimulating hormone, luteinizing, free testosterone, DEA-sulfate, 17-OH-progesterone, cortisol is determined. 7 days after ovulation, the level of progesterone should be determined. Women with insufficient endometrial thickness have low progesterone levels.

Often the culprit low rate the thickness of the endometrium in a woman is a pathology of the blood coagulation system. The group of diseases that initiate hypercoagulability - increased blood clotting - is extensive. Often, patients are found to have PAI mutations, thrombophilia, elevated homocysteine ​​levels, and a number of other pathologies.

After the aspiration, specialists determine a number of its possible pathologies at histological examination which could lead to insufficient thickness. The resulting material is treated with reagents to determine the amount of estrogen receptors (immunohistochemistry). With hypoplasia, they are found an insufficient amount. Histology reveals the presence of endometritis according to a number of characteristic features.

In order to increase the chances of pregnancy, experts also resort to invasive diagnostic methods. Hysteroscopy allows the doctor to visually assess the condition of the endometrium, exclude neoplasms, adhesive process, endometriosis, polyps, fibroids. In addition, when performing this procedure, it is possible to check the patency fallopian tubes which also increases the range of diagnostic possibilities. In the process of hysteroscopy, the doctor selects a piece of tissue for further research (aimed biopsy). separate diagnostic curettage applied in exceptional cases.

Methods of treatment

Complex medical measures aimed at increasing the thickness of the inner layer of the uterus, should cover all links in the pathogenesis of the disease. The main directions of therapeutic methods are distinguished:

• the appointment of drugs that increase blood flow in the endometrial layer;
• elimination of infectious and inflammatory processes in the endometrium;
• taking hormonal drugs to increase estrogen levels.

When trying to increase the size of the endometrium, it is important to improve its condition in order to create an "implantation window" - short span the time it takes for a fertilized egg to implant. That is why the treatment of hypoplasia of the inner uterine layer should be multidirectional and complex.

hormone therapy

To increase the chances of conception, it is necessary to restore the proper level of the female sex hormone estrogen. The thickness of the endometrium can be increased due to the artificial replenishment of estradiol. The chances of success are largely determined by the response of endometrial growth to hormone intake, which in turn depends on the number of estrogen receptors.

Effective and popular means, allowing to increase the thickness of the endometrium, are transdermal estrogens, produced in the form of a gel.

Hormonal gels containing estrogen to increase estradiol levels are convenient to use and are characterized by high level security. Gels are identical in structure to natural hormonal substance and allow you to increase the level of your own in a short time. In addition, such medications significantly reduce the risk of blood clotting, which is unacceptable with an increase in the thickness of the endometrium. local remedy, applied to the skin, does not pass the first stage of metabolism in the liver, which leads to a permanent preservation required amount estradiol in a woman's blood. This fact significantly increases the chances of increasing the size of the inner uterine layer, since estrogen fluctuations do not occur.

Most often, gynecologists prescribe Divigel, starting therapeutic dose which is 1 mg per day. The gel is applied to the skin of the abdomen from the 5th day of the cycle until the first day of the subsequent menstruation. In the event that menstruation does not occur, the application of the remedy is continued under the supervision of a physician. If the indicators have been increased and there are assumptions about the onset of pregnancy, Divigel continues to be used until it is confirmed by ultrasound.

In the process of treating hypoplasia of the inner uterine layer, the reaction of the endometrium to the effect of the drug is evaluated. If it is not possible to increase the thickness, the dosage of the gel is increased. Maximum dose is 2 mg per day. It should be borne in mind that it is possible to increase the dose of the agent only at the end of the 1st phase of the cycle - before ovulation. Otherwise, the growth of follicles may be slowed down. This fact should be taken into account when planning pregnancy. An increase in the dose of hormonal agents with estrogen, which allows to increase the thickness of the endometrium, is carried out with a follicle size of at least 14-15 mm.

When planning a pregnancy and trying to increase the size of the inner uterine layer with the help of hormones, ultrasound monitoring or folliculometry is necessary. Estrogens are able to suppress the growth of the dominant follicle, which can lead to an anovulatory cycle. An ultrasound examination is performed on the 5th, 9th, 13-14th day of the menstrual cycle. If necessary, perform additional ultrasound to confirm ovulation.

Treatment of endometrial hypoplasia should be comprehensive. The dose of hormones that increase the endometrium is selected individually. The terms of hormonal treatment for the onset of pregnancy are approximately 2-4 menstrual cycles. With a properly selected therapy regimen, it is possible to increase the thickness of the inner uterine layer within the specified time frame.

In addition to Divigel, estrogen tablets are also used, for example, Proginova. As a rule, to increase the thickness of the endometrium, the drug is taken for 21 days of the cycle for several months. To improve the condition of the endometrial layer in the second phase, gestagens are used (Norkolut, Dufaston, Utrozhestan). Gestagens are not included in all schemes for increasing the thickness of the uterine layer.

In addition to estrogen-based products, in order to increase the thickness of the endometrium, complexes containing polyunsaturated fatty acids, vitamin D, E are used. These substances play a role in the synthesis of hormones, and are also necessary for growth and maturation, normal process cell division.

Upon detection advanced level male sex hormones and their metabolites are prescribed means to reduce them. To increase the production of female sex hormones and, androgens reduce hormonal means. use oral contraceptives with antiandrogenic effect (Yarina, Belara and others), as well as corticosteroids (Dexamethasone and its preparations).

Normalization of blood circulation in the uterus

When a patient is diagnosed with pathologies of hemostasis, blood thinners are included in the treatment regimen. Also used to strengthen vascular wall, vitamins, medicines that improve venous outflow.

The process of drug treatment of endometrial hypoplasia is accompanied by the appointment of drugs that increase blood flow in the uterus. In addition, estrogen therapy has side effects such as blood clotting, which can also negatively affect attempts to increase the thickness of the endometrial layer.

The main group of drugs for the treatment of circulatory disorders with insufficient thickness of the endometrium are low molecular weight heparins.

Among the most popular means Fraxiparine, Clexane are considered, which are used both at the stage of pregnancy planning and at its onset to prevent miscarriage. Apart from low molecular weight heparins prescribe Curantil, Thromboass, low doses of Aspirin. Means thin the blood and contribute to the normalization of blood flow in the inner uterine layer.

In order to increase blood flow in the uterus, diosmins are used - Venarus, Detralex, Phlebodia - means that help strengthen the walls of the veins, normalize the condition venous blood, lymph drainage. Especially often they are prescribed in the presence of varicose disease. Actovegin is used to activate endometrial trophism and improve regeneration processes.

Immunocorrection

The impact on the immune response in thin endometrium is relevant in combination with such pathologies as chronic endometritis, the presence of antibodies to hCG, and in autoimmune diseases.

In order to increase the chances of successful pregnancy, all infectious and inflammatory diseases of the endometrium must be eliminated. Treatment chronic endometritis presents a difficult task. chronic inflammation often accompanied by insufficient thickness of the endometrium. After a thorough diagnosis and confirmation of the pathology, antibiotic therapy and immunomodulation. To increase the immune response, drugs such as interferons, interleukins are used. Stimulants Polyoxidonium, Likopid, Echinacea-based products are also used. With immune infertility, immunoglobulins are used.

Immunocorrection allows not only to increase the thickness of the endometrium, but also to increase its receptivity - to normalize the number of receptors for estrogen and progesterone.

In addition to immunomodulators high efficiency in the aspect of normalizing the immune response, B vitamins, antioxidants (A, E, C) have.

herbal remedies

Hormonal treatment of thin endometrium is supplemented by the introduction into the diet herbal ingredients, which contain necessary substances to accelerate the growth and maturation of the cells of the inner uterine layer. These foods and plants include:

• pineapples;
• raspberries;
• mint;
• seeds and nuts;
• pumpkin;
• sage.

To increase the thickness of the endometrium, these foods and herbs can be consumed daily throughout the course of treatment.

Against the background of the main therapy, courses of leeches, acupuncture, electrophoresis with zinc, and mud therapy are used. Moderate physical activity also has a positive effect on increasing the thickness of the endometrium by improving blood circulation in the pelvis.

The endometrium is the inner mucosal layer of the uterus, the thickness of which depends on the phase menstrual cycle and from the hormonal background of a woman. When the last premenstrual phase of the cycle comes, the endometrial layer noticeably thickens, is enriched with glands, which ensures better blood supply to the tissues. An increase in the thickness of the endometrium plays important role for conception, since it is in this layer that the implantation of a fertilized egg occurs. If the thickness of the layer is insufficient to secure the embryo, it is removed from the uterine cavity during menstruation, even if fertilization has occurred.

This article will describe how to build up the endometrium with the help of medicines and traditional medicine in order to create optimal conditions for the onset of pregnancy.

Functions of the endometrium

A healthy endometrium is whole system, which includes several components:

• integumentary and glandular epithelium;
• blood vessels;
• stroma in the form of supporting connective tissue, which during menstruation begins to produce collagen and other substances useful to the body.

The main function of the endometrial layer in women is to create favorable conditions for implantation and development of the fetus in the uterine cavity. If the embryo is successfully fixed, the number of blood vessels in the endometrium increases significantly, which will later become part of the placenta. These same vessels deliver oxygen to the growing embryo and provide it with all the necessary nutrients.

Why does it get thin

In order for a fertilized egg to be properly fixed in the uterus, it is necessary that the endometrium has the appropriate thickness and structure, but there are a number of factors that interfere with the inner layer reproductive organ develop properly:

• congenital anomalies, which provoke a deficiency of female sex hormones or a complete cessation of their production;
• hormonal imbalance. Disturbances in the production of hormones cause the fact that slime layer cannot grow normally on certain days. In this case, there is thin endometrium throughout the cycle;
• violation of blood circulation in the uterus. This cause can be provoked by injuries, inflammation, abortion, diseases of the pelvic organs. Most often, the uterine mucosa suffers during curettage, which greatly reduces a woman's chances of conceiving a baby;
• uterine hypoplasia. This is a disease in which the size of the genital organ does not correspond to the age of the patient.

The hormone estradiol, which is produced during the normal maturation of the follicle, is responsible for the normal maturation of the endometrium. With a lack of this hormone, the inner layer of the uterus may not only not ripen, but receptors for progesterone, a hormone that is also important for normal flow pregnancy.

In all listed cases if a woman wants to become pregnant, she needs to build up an additional uterine mucosa.

What indicates thinning

The very first reason that the endometrium of the uterus has become thinner is menstrual disorders, in which the discharge is scarce and short-term. Other characteristic symptom are infertility and constant spontaneous abortions.

If the cause of the pathology is a lack of estradiol, then the woman has symptoms similar to menopause. Such patients often complain of headaches, mood swings, causeless depression or irritability. Also, women have problems with sleep, desire disappears, jumps arterial pressure, muscles, joints hurt and hot flashes appear.

Such symptoms require a mandatory visit to a specialist, perfect choice become a gynecologist-endocrinologist.

Diagnostics

Before choosing a method by which the endometrial layer will increase, the doctor needs to carry out a number of diagnostic procedures.

The following measures will help to establish the cause of this pathology:

• gynecological examination;
• Ultrasound of the pelvic organs in different days cycle;
• blood test for hormones;
• uterine biopsy.

In some cases, you may need to consult an endocrinologist.

Why do women want to build up a layer of the endometrium

The main reason why women want to enlarge the endometrium is the desire to become pregnant and bear healthy offspring.

When planning pregnancy and before IVF in without fail the gynecologist conducts a series of examinations on different days of the cycle to determine the thickness, structure of the endometrium and the success of achieving the required threshold of maturity of the endometrial surface layer. It is the presence of all these criteria that is necessary for the fetus to take root and develop normally in the uterine cavity.

One of the consequences after curettage may be the thinning of the endometrium, this should be taken into account by women planning new pregnancy after such surgeries.

What to take for endometrial growth

The main method by which the endometrium is built up is the use of medicines, but for this purpose, according to the doctor's prescription, physiotherapy procedures and even traditional medicine recipes can be used.

Since the endometrial layer grows under the influence of hormones, hormonal preparations are most often used to thicken it. It can be not only tablets, but drops, suppositories, gels. Depending on the level of which hormone is not normal, the list of drugs may differ, they may be based on artificial estradiol, estrogens or progesterone.

Proginova

Part this medicine included estradiol and estrogens. This remedy improves blood circulation in the uterus. It is prescribed to women who have a history of spontaneous abortions, since Proginova is able to have a restorative effect on the body.

Since this drug can build up the endometrium, it is very often included in the complex of preparations for IVF. The treatment regimen is determined by the doctor, but there are 2 options for taking Proginov:

1. Cyclically. Tablets to drink 1 piece for 3 weeks. Then one week break is made and the treatment is repeated.
2. Continuously. Tablets are taken without interruption.

The drug has a number of contraindications:

• first trimester of pregnancy;
• lactation period;
• taking drugs based on estrogens;
• uterine bleeding;
• oncology;
• diseases of the gall and liver;
• diabetes.

Divigel

The main component of this drug is estradiol or synthetic estrogen. Thanks to Divigel, you can not only quickly build up the endometrium, but also activate the activity of the uterus, mammary glands and vagina. used this drug once a day at the same time.

Divigel must be applied to clean skin lower abdomen, lower back, buttocks and shoulders. The dose of the medicine is prescribed by the attending physician.

In no case should the product be applied to inflamed areas, mucous surfaces and the chest.

The drug has a number of contraindications:

• diabetes;
• pituitary tumor;
• predisposition and formation of blood clots;
• oncological and inflammatory processes in the breast and reproductive organs;
• uterine bleeding;
• pregnancy;
• breast-feeding;
• disturbed lipid metabolism;
• kidney and liver diseases.

Gormel

Gormel drops are homeopathic preparations which activates the synthesis of estrogen. It consists exclusively of natural substances and alcohol.

To build up the endometrial layer, it is enough to take 10 drops of the product in half a glass of water half an hour to an hour before meals. You need to drink the remedy three times a day for 1-3 months. Usually Gormel is part of complex therapy.

It is forbidden to drink it to pregnant, lactating women, women with liver diseases and brain injuries.

Other drugs

Some women believe that to increase the thickness of the endometrium, you need to take hormonal drugs with progesterone, such as Duphaston and Utrozhestan. These drugs are absolutely harmless to the female body, but they cannot build up an additional mucous layer, but only contribute to its maturation in the uterus.

Of the other medicines to increase the endometrial layer, injections of estradiol and salicylic drugs can be prescribed.

How to build up the endometrium with folk methods

Many women are interested in how to increase the thickness of the uterine mucosa with folk remedies. It should be noted right away that treatment at home should be only after consultation and with the permission of the attending physician. As practice shows, good effect in the build-up of the endometrium, drugs based on medicinal plants are shown.

Sage

Plant hormones in sage increase estrogen levels, which is important for the growth of the inner uterine layer and stimulate the activity of the follicles. To make a decoction of this plant, you need to take a tablespoon of dry raw materials, grind and pour a glass of water. The resulting mixture is boiled for 15 minutes from the moment of boiling, cooled. To drink sage to build up the endometrium, you need a third of the resulting mixture 4 times a day. You need to start using the medicine from the 4th day of the cycle and complete it on the day the egg leaves the follicle.

Boron queen and red brush

Both of these herbs are able to influence the hormonal balance of a woman and eliminate inflammation. A decoction of the red brush is taken in the first phase of the menstrual cycle, starting from last day monthly.

BUT upland uterus you need to drink after ovulation. To prepare a decoction, you need to take a tablespoon of dry raw materials, pour a glass of boiling water and leave for 3 hours. Drink 0.1 liters three times a day.

pumpkin juice

Pumpkin in any form can improve the condition of the endometrium, in order to build it up you need to drink freshly squeezed pumpkin juice 2-3 times a day, you can use raw pumpkin in salads, bake in the oven and add the grated product to casseroles, pancakes and puddings. If the structure of the endometrium is disturbed due to inflammatory processes in the pelvic organs, then therapeutic tampons in the vagina can be made from pumpkin and pumpkin oil.

pineapples

Some women believe that pineapple juice will help increase the lining of the uterus. Pineapples for endometrial growth really help well, because they have a large supply of vitamin C. This fruit improves hormonal levels, strengthens blood vessels and normalizes blood circulation, in addition, it strengthens the immune system and prevents blood clots.

There is no limit on the number of pineapples eaten, but you need to start a pineapple diet at least a couple of days before ovulation. This method of thickening the endometrial layer is not suitable for women allergic to vitamin C.

Blue clay

Blue clay should be mixed in warm water. It will help build up the endometrium if at least 0.5 kg of this remedy is used daily.

Before starting the procedure, the mixture is slightly heated, placed on an oilcloth surface in the form of a cake, which is placed on the stomach. This compress should warm the stomach for at least 2 hours. Already after 5 days you can feel the positive effect.

raspberry leaves

Raspberry leaves provide beneficial effect for the endometrium, they stimulate its growth and normalize the condition. The infusion of raspberry leaves contains plant estrogen, which helps to improve the functioning of the ovaries. It is enough to pour leaves with boiling water and drink instead of tea. The tool improves blood circulation in the pelvic organs and enhances the production of mother's milk.

other methods

In order not to use a large number of medicines to help build up the inner mucous layer of the uterus, there will be many others no less effective methods alternative medicine. Let's consider each of these methods in more detail.

Hirudotherapy

Therapeutic leeches are able to normalize blood circulation in the pelvic organs and increase the thickness of the endometrium from the very first sessions.

Massages and acupuncture

Both procedures are designed to influence certain active points by pressing and stroking in massage or by inserting special needles in acupuncture. Experienced Massage Therapist or chiropractor is able to activate the work of the affected organ in several sessions and affect the thickening of the endometrium.

Vitamins C and E

Products with vitamins C and E will help speed up the growth process of the endometrium. There is a lot of vitamin C in pineapples, tangerines, lemons and black currants. Vitamin E in large quantities found in milk, fresh vegetables, flax seeds, and raspberry leaves, which can be brewed instead of tea.

Physical exercises

Physical exercises can strengthen the abdominal press, improve blood circulation in the pelvic organs and in the uterine cavity, and also increase the thickness of its mucosa. But not in every case, high physical activity for gynecological problems is allowed, so before signing up for a gym, you need to consult a doctor. Everyone is allowed to do exercises and walk in the fresh air for at least half an hour a day. good efficiency show aerobics, running, dancing and swimming.

Proper nutrition

The build-up of the endometrium with medications must be combined with the correct and balanced diet. You need to eat often and in small portions, while fatty, spicy and salty foods should be excluded from the diet. The menu should contain foods containing a large amount of vitamin C and E - citrus fruits, fresh vegetables, fruits, milk. You also need to eat foods high in salicylates - raisins, blueberries, grapes, prunes, cranberries, cherries. Speaking of spices, these substances are found in cinnamon, mint, thyme, paprika, dill, curry and ginger. In addition, the components necessary for building up the endometrium are found in honey, wine, vinegar and chewing gum. Eat seafood rich in omega-3s fatty acids- tuna, mackerel, shrimp, anchovies, etc.