First obstetric department. Postpartum obstetric physiological departments

The drug Magnesia

Magnesium sulfate(Magnesia, magnesium sulfate, Epsom salt, etc.) includes magnesium salt of sulfuric acid. Impurities and excipients this drug does not contain.

The effectiveness of this drug has long been proven, and the drug is successfully used in various branches of medicine (gynecology, neurology, gastroenterology and many others) due to the numerous effects it has.

Spectrum of action Magnesia:

vasodilator;
antispasmodic (with analgesic effect);
tocolytic (leads to relaxation smooth muscle uterus);
anticonvulsant;
antiarrhythmic;
weak diuretic;
soothing;
choleretic;
laxative.

Certain properties of Magnesia appear depending on the route of administration of the drug into the body.

When administered orally (through the mouth in the form of a powder suspension), within 1/2 - 3 hours Magnesia has a laxative and choleretic effect, lasting for 4 or 6 hours. Stool loosening is achieved by the fact that the drug promotes the flow of water into the intestinal lumen and dilutes stool, which, increasing in volume, causes more active intestinal motility and defecation. Improved bile outflow is caused by irritation of the walls of the duodenum and an antispasmodic effect. Part of Magnesia is excreted by the kidneys and therefore can be used to achieve a diuretic effect.

In addition, magnesium sulfate, taken in the form of a suspension, can be used as an antidote for poisoning by mercury, lead, barium salts and arsenic. This effect of Magnesia can be explained by the fact that it is able to bind to a toxic substance and, having a laxative effect, quickly remove it from the body with feces.

When Magnesia is administered intravenously and intramuscularly, an anticonvulsant, hypotonic, antiarrhythmic, sedative and vasodilating effect is achieved. High doses of magnesium sulfate can cause tocolytic, narcotic and hypnotic effects.

When administered intramuscularly, the drug begins its effect after 1 hour and its effect continues for 3-4 hours, and when administered intravenously, it acts instantly for 30 minutes.

Magnesia solution can be used for electrophoresis, medicinal baths, compresses and local impact on wound surfaces.

Electrophoresis with a solution of magnesium sulfate has a vasodilating and calming effect. In some cases, this physical therapy procedure can be used to treat warts.

Local application of Magnesia for dressings and compresses helps improve blood flow in the skin tissues and achieve an analgesic and absorbable effect.

Sports magnesium is used to dry hands. This ensures a reduction in the slipping of the athlete’s hands when gripping a particular sports apparatus or equipment.

Release form

Magnesia is available in various forms:

1. In ampoules of 10 ml - 25% solution (10 pcs. per package).

2. In ampoules of 5 ml - 25% solution (10 pieces per package).

3. Powder for preparing the suspension - in packages of 10, 20 and 25 g.

4. Powder, balls, briquettes of magnesium sulfate for athletes – various shapes release and packaging.

Instructions for use of MagnesiaIndications for use

Brain swelling;
encephalopathy;
epilepsy;
eclampsia;
threat premature birth;
hypomagnesemia (magnesium deficiency in the blood);
ventricular arrhythmias (including with low concentrations of potassium and magnesium in the blood);
excessive nervous excitability (with epilepsy, increased mental and motor activity, convulsions);
increased sweating;
hypotonic biliary dyskinesia;
cholecystitis;
duodenal intubation;
bronchial asthma;
heavy metal poisoning;
constipation;
urinary retention;
treatment of warts;
treatment of wounds and infiltrates.

Contraindications

Arterial hypotension;
atrioventricular block (impaired conduction of impulses from the atria to the ventricles);
severe bradycardia;
prenatal period;
appendicitis;
severe renal failure;
rectal bleeding;
dehydration;
intestinal obstruction.

Side effects

Depression of the heart;
bradycardia;
arrhythmias;
flushes of blood to the face;
sweating;
oppression of the central nervous system;
asthenia;
headache;
state of anxiety;
confusion;
low temperature;
vomiting or nausea;
polyuria;
diarrhea;
flatulence;
thirst;
spasmodic pain.

Interaction with other drugs

When administered intravenously or intramuscularly with a solution of magnesium sulfate simultaneously with certain other medications, an increase or decrease in the effect of a particular drug may be observed:

when magnesia is combined with peripherally acting muscle relaxants, the effect of muscle relaxants is enhanced;
with Nifedipine - severe muscle weakness may be provoked;
with anticoagulants (oral), cardiac glycosides, phenothiazine - the effectiveness of the drugs decreases;
with Ciprofloxacin – the antibacterial effect increases;
with Tobramycin and Streptomycin - the antibacterial effect is reduced;
with tetracycline antibiotics - the effectiveness of antibiotics decreases and their absorption from the gastrointestinal tract decreases.

Magnesia is not compatible with some pharmacological drugs:

calcium;
barium;
strontium;
arsenic salts;
carbonates, phosphates and hydrocarbonates of alkali metals;
procaine hydrochloride;
tartrates;
salicylates;
Clindamycin;
Hydrocortisone.

In case of an overdose of Magnesia, it is recommended to use calcium preparations (Calcium gluconate, Calcium chloride) as an antidote.

Treatment with magnesia How is Magnesia taken orally? To use Magnesia internally, a suspension is prepared from powder and warm boiled water. The dosage of magnesium sulfate when taking this drug orally depends on the indications and age of the patient.

If Magnesia is used as a choleretic agent, it is used in the following way:

20-25 g of powder is dissolved in 100 ml of warm boiled water;
Before taking, stir the solution and immediately drink 1 tablespoon of the medicine;
The solution must be taken before meals 3 times a day.

For performing duodenal sounding prepare a solution of 10% or 25% concentration, and introduce the prepared solution into the duodenum through a probe (10% - 10 ml or 25% - 50 ml).

As a laxative:

for adults and children over 14 years of age, a solution is prepared from 10-30 g of magnesium sulfate powder (the powder is diluted in 100 ml of warm boiled water);
the resulting solution is taken at night or in the morning before meals;
To speed up the laxative effect, you can take it additionally a large number of warm boiled water (in this case, loosening of the stool will occur within 1-3 hours).

In some cases, to combat chronic constipation, medicinal enemas with a solution of magnesium sulfate (20-30 g per 100 ml of water) may be prescribed.

Intravenous and intramuscular administration of Magnesia When using Magnesia as an anticonvulsant, antihypertensive, antiarrhythmic agent, the drug is administered intramuscularly or intravenously.

For intramuscular administration, a 25% solution is used, produced in ampoules, which does not require additional dilution. When administering this drug intravenously, the ampoule solution can be administered undiluted or diluted with a solution of sodium chloride or 5% glucose.

Usually, for intravenous use, Magnesia solution is diluted, since rapid simultaneous administration in undiluted form can provoke a number of complications.

Intramuscular administration of Magnesia is accompanied by painful sensations.

Before giving an injection or drip nurse should warn the patient that if a number of symptoms appear (dizziness, headache, flushing of the face, decreased heart rate), it is necessary to immediately report them to the doctor. The drip infusion itself may be accompanied by a slight burning sensation along the vein, which gradually stops. At the end of the drip infusion, reference measurement pressure and pulse.

Magnesia dosage When taken orally, the highest single dose of Magnesia is 30 g.

The maximum daily dose of Magnesia for intravenous or intramuscular administration is 200 ml of a 20% solution.

Magnesia for children

Quite often Magnesia is used to treat

in children. For these purposes, the powder of the drug is used, which is diluted in 100 ml of warm boiled water. The dosage depends on the age of the child:

6-12 years – 6-10 g per day;
12-15 years – 10 g per day;
over 15 years old – 10-30 g per day.

To determine a more accurate daily dose For magnesium, you can use the following formula: 1 g multiplied by 1 year of the child (for example: a 7-year-old child can be given 7 g of Magnesia powder per day).

For constipation in children, magnesium sulfate can also be used in the form of medicinal enemas. For an enema, you need to prepare a solution of 20-30 g of powder and 100 ml of warm boiled water. The amount of solution for administration into the rectum, depending on the age of the child, is 50-100 ml.

Magnesia is prescribed intravenously or intramuscularly to children only for relief of emergency conditions (severe asphyxia or intracranial hypertension). In these cases, intravenous or intramuscular administration of Magnesia is used even for newborns.

Magnesia during pregnancy

Magnesia at

pregnancy

It is most often used to relieve hypertonicity of the uterus (relaxation of its smooth muscles). These measures become necessary in conditions such as a threat

miscarriage

or premature

In such cases, intravenous or intramuscular administration of Magnesia is used in a hospital setting, under the constant supervision of medical personnel. This is explained by the fact that when administered intravenously, this drug enters not only the mother’s blood, but also, passing through the placental barrier, enters the fetal blood. Thus, Magnesia can cause respiratory depression in the fetus and a sharp decline blood pressure. Due to the possible development of such complications, stop using Magnesia solution 2 hours before the expected birth.

Due to its diuretic effect, Magnesia can be used during pregnancy to reduce edema (for example, in preeclampsia and eclampsia). In this case, a solution of magnesium sulfate is introduced dropwise, slowly. To avoid complications, the doctor monitors the dynamics of pressure, respiratory rate, concentration of magnesium ions in the blood and tendon reflexes.

Tubazhi with Magnesia

Tubage with Magnesia improves the movement of bile through bile ducts and can be an excellent preventive measure

cholelithiasis

This procedure can be carried out in a medical facility or, as prescribed by a doctor, at home.

Indications for tubing:

bile duct dyskinesia;
stagnation of bile in the gallbladder.

Contraindications:

cholelithiasis;
rectal bleeding;
intestinal obstruction;
dehydration of the body;
tendency to hypotension;
attack of appendicitis;
high levels of magnesium in the blood;
exacerbation of any chronic disease;
elevated body temperature.

Magnesia, available in powder, and boiled water are used for tubage. Tubage with Magnesia is carried out in the morning once a week. It is most effective to carry out this procedure within 15 weeks (unless your doctor prescribes otherwise).

Before the procedure, it is advisable to follow a gentle diet, which should be followed on the day of the procedure. You should avoid spices, smoked, pickled and salty foods. The diet can include various porridges (except millet, pearl barley and semolina) and dishes from boiled or baked vegetables.

Procedure:1. Stir 1 tablespoon of Magnesia powder in 250 ml of warm boiled water (you can use purified drinking water heated to 40 degrees or alkaline mineral water without gas).

2. Drink the prepared mixture.

3. Lie on your right side.

4. Apply a heating pad or a bottle of warm water to the liver area.

5. Lay down for about 1.5 hours.

The effectiveness of the tubing can be determined by color feces. The procedure is considered successful if the first stool excreted has a greenish tint. If there is no stool, constipation should be eliminated and the tubage procedure with Magnesia should be performed again.

After completing the tubage procedure, it is advisable to eat a salad of grated boiled beets, seasoned with vegetable oil, or of grated raw carrots and apples.

Magnesia for colon cleansing

intestines

Magnesia can be used not only to eliminate constipation, but also to remove toxins accumulated on the intestinal walls from the body. This technique guarantees bowel cleansing and, when performed correctly, is considered safe.

The procedure can be performed both in hospital and at home in the absence of contraindications to it. To carry it out, a medicinal enema is performed from dry Magnesia powder and warm boiled water. 20-30 g of dry powder are dissolved in 100 ml of warm boiled water. The resulting solution is injected into the intestinal lumen and causes swelling of the feces. Within 1-1.5 hours, toxins accumulated on the intestinal walls are removed from the body along with feces.

Such enemas are performed in one course, and their number is determined by the doctor. In recent years, there have been many opponents of such bowel cleansing among doctors, who point to a number of possible complications. Other experts, on the contrary, advocate the advisability of such cleansing procedures, but recommend carrying them out only after consultation with a doctor.

Magnesia in physiotherapy

Magnesia is used for some physiotherapeutic procedures:

compresses - a 25% solution is used, the compress is applied to the desired area for 6-8 hours, then the skin is washed with warm water and lubricated with a rich cream (since magnesium sulfate has a drying property);
electrophoresis - can be performed using different methods; a 20-25% solution is used to carry it out;
medicinal baths– dry magnesium sulfate powder is used, which is dissolved in water; The water level in the bath should not reach the level of the heart.

Compresses with Magnesia have a warming property and increase blood flow to the skin. They can be used to treat infiltrates after injections, diseases of the joints and muscles.

The purpose of electrophoresis with Magnesia is more extensive. Under the influence of electrodes, a solution of magnesium sulfate penetrates into the deep layers of the skin and blood vessels, which helps normalize the psycho-emotional background, blood circulation and muscle condition. The duration of the procedure depends on the indications, health status and age of the patient.

Therapeutic baths with Magnesia are used not only to relieve physical and psycho-emotional stress, but can also be used to provide the following therapeutic effects:

decreased blood pressure;
increased blood microcirculation;
elimination of spasms of small bronchi;
prevention of seizures in pregnant women;
increased blood circulation in the genitourinary organs;
muscle relaxation;
strengthening metabolic processes;
recovery after serious illnesses and injuries.

Magnesia for weight loss

Losing weight with the help of Magnesia is becoming quite popular among those who are trying to lose excess weight. For this purpose, it is used internally (as a laxative) and in the form of baths.

According to the recommendations of this weight loss technique, Magnesia should be taken orally to activate digestive processes and regularly loosen stools. The drug is prepared in the same way as to provide a laxative effect.

To prepare baths, use a mixture of Magnesia with table salt and salt Dead Sea. Before preparing the solution, approximately 100 liters of water (about 40oC) are taken into the bath, in which a mixture of salts is dissolved.

Composition of the bath salt mixture:

4 packages of 25 g of Magnesia;
500 g table salt;
500 g Dead Sea salt.

The procedure should take no more than 25 minutes. After taking a bath, it is recommended to dry the skin and apply a moisturizing cream or lotion to it.

The bath has a beneficial effect on the skin and the body as a whole: it promotes the elimination excess fluid from subcutaneous fat, normalization of metabolism and psycho-emotional state. In addition, along with sweat from upper layers toxins are removed from the skin.

It is possible to lose weight with the help of such baths, but only if you follow a rational diet and sufficient physical activity.

Like any physical procedure, a bath with Magnesia for weight loss can not always be used, but only after eliminating contraindications to it.

Absolute contraindications:

infectious diseases;
active tuberculosis;
chronic diseases in the stage of decompensation;
exhaustion;
high blood pressure;
acidosis in diabetes mellitus;
tumors;
psychoses;
epilepsy.

Relative contraindications:

hypothyroidism;
urolithiasis disease;
hypertension with a stable blood pressure of 160/120 and above.

Read more about losing weightMineral water "Magnesia"Mineral water "Magnesia" is natural, it has high level content of magnesium ions and bicarbonates. That is why it is recommended for use in the treatment of diseases associated with magnesium deficiency in the body. Magnesium mineral waters are recommended for the treatment of:

gastritis accompanied by constipation;
pancreatitis;
liver diseases;
diseases of the nervous system accompanied by stress or seizures;
diseases of the teeth and musculoskeletal system (osteoporosis, demineralization of teeth, caries, etc.);
diseases of the genitourinary system;
obesity degrees I-III.

It is recommended to take Magnesia mineral water in medicinal purposes only after preliminary consultation with a doctor, since its appointment requires an individual determination of the duration of treatment and the number of courses.
Magnesia sports

Magnesia is actively used in some types

And active rest. This is because when applied to the skin, magnesium sulfate leaves a film that absorbs sweat and eliminates friction that can occur between sports equipment and the hand. In the same way, it helps to increase friction between the fingers.

These properties of magnesium sulfate are actively used by athletes, climbers and people in certain professions. In recent years, for ease of use, products have begun to be produced in the form of balls or briquettes, which are made from compressed Magnesia. When crushed, they turn into a powdery state.

Sports magnesium: anti-slip agent - video
Reviews about the drug

Reviews about Magnesia, which can be found on numerous forums, are different. Many patients who took this drug orally for a laxative effect and as a choleretic agent rate it positively. Only some of them experienced discomfort in the abdomen caused by spasm of the smooth muscles of the intestine. This unpleasant moment can be explained by the fact that the drug was not used as prescribed by a doctor or the dosage was exceeded. Abdominal pain can also be explained by increased mental or nervous excitability.

Evaluating the review of reviews from patients who took magnesium sulfate orally for weight loss, we can conclude that this technique unjustified and may provoke serious violations in activities digestive system and metabolism. Magnesia baths taken for weight loss in most cases cause dry skin.

When using Magnesia for intramuscular and intravenous administration, judging by the reviews of most patients, pain is noted at the injection site. When administered intramuscularly with a solution of magnesium sulfate, infiltrates may form, which, when timely treatment are eliminated and do not cause serious complications. Pain and slight burning along the vein during intravenous infusions, noted by some patients, can be explained by improper dilution of the drug, its rapid administration, or excessive impressionability of patients who have previously heard stories from friends or read reviews on forums.

Drug price

Magnesia is available in various forms, and its price may vary depending on the region, the manufacturer and the selling pharmacy:

in ampoules of 10 ml - 25% solution (10 pieces per package) - from 21 to 65 rubles;
in ampoules of 5 ml - 25% solution (10 pieces per package) - from 17 to 51 rubles;
powder for preparing the suspension in packages of 10, 20, 25 g - the price depends on the weight of the package and ranges from 2.5 to 23 rubles;
powder, balls, briquettes of magnesium sulfate for athletes - various forms of release and packaging at different prices.

ATTENTION! The information posted on our website is for reference or popular information and is provided to a wide range of readers for discussion. Prescription of medications should only be carried out qualified specialist, based on medical history and diagnostic results.

In this article you can read the instructions for use of the drug Magnesia. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Magnesia in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Magnesia in the presence of existing structural analogues. Used to treat constipation, reduce high blood pressure, carrying out tubing in adults, children, as well as during pregnancy and breastfeeding.

Magnesia- when taken orally, it has a choleretic effect ( reflex action on the receptors of the mucous membrane of the duodenum) and a laxative effect (due to poor absorption of the drug in the intestine, a high osmotic pressure, water accumulates in the intestines, the intestinal contents become liquefied, and peristalsis increases). It is an antidote for poisoning with heavy metal salts. The onset of the effect is after 0.5-3 hours, duration is 4-6 hours.

At parenteral administration has a hypotensive, sedative and anticonvulsant effect, as well as a diuretic, arteriodilating, antiarrhythmic, vasodilating (on arteries) effect, in high doses- curare-like (depressant effect on neuromuscular transmission), tocolytic, hypnotic and narcotic effects, suppresses respiratory center. Magnesium is a physiological blocker of slow calcium channels and is able to displace it from binding sites. Regulates metabolic processes, interneuronal transmission and muscle excitability, prevents the entry of calcium through the presynaptic membrane, reduces the amount of acetylcholine in the peripheral nervous system and the central nervous system. Relaxes smooth muscles, reduces blood pressure (mostly elevated), increases diuresis.

The mechanism of anticonvulsant action is associated with a decrease in the release of acetylcholine from neuromuscular synapses, while magnesium suppresses neuromuscular transmission and has a direct inhibitory effect on the central nervous system.

The antiarrhythmic effect of magnesium is due to a decrease in the excitability of cardiomyocytes, restoration of ionic balance, stabilization cell membranes, disturbance of sodium current, slow incoming calcium current and one-way potassium current. The cardioprotective effect is due to the expansion coronary arteries, decreased peripheral vascular resistance and platelet aggregation.

The tocolytic effect develops as a result of inhibition contractility myometrium (decreased absorption, binding and distribution of calcium in smooth muscle cells) under the influence of magnesium ion, increased blood flow in the uterus as a result of dilation of its vessels. Magnesium is an antidote for poisoning with heavy metal salts.

Systemic effects develop almost immediately after intravenous and 1 hour after intramuscular administration. Duration of action with intravenous administration is 30 minutes, with intramuscular administration - 3-4 hours.

Compound

Magnesium sulfate + excipients.

Pharmacokinetics

After oral administration, no more than 20% of the dose taken is absorbed. Penetrates the blood-brain barrier (BBB) and the placental barrier and is excreted from breast milk with a concentration 2 times higher than plasma concentrations. Excreted by the kidneys, the rate of renal excretion is proportional to plasma concentration and glomerular filtration rate.

Indications

For oral administration:

constipation;
cholangitis;
cholecystitis;
gallbladder dyskinesia hypotonic type(for performing tubazhs);
duodenal intubation (to obtain a cystic portion of bile);
bowel cleansing before diagnostic procedures.

For parenteral administration:

arterial hypertension (including hypertensive crisis with symptoms of cerebral edema);
threat of premature birth;
convulsions during gestosis;
hypomagnesemia (incl. increased need in magnesium and acute hypomagnesemia - tetany, myocardial dysfunction);
polymorphic ventricular tachycardia (pirouette type);
eclampsia;
encephalopathy;
epileptic syndrome;
urinary retention;
poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

Release forms

Solution for intravenous and intramuscular administration (injections in injection ampoules).

Powder for the preparation of suspension for oral administration in jars of 20 g, 25 g, 40 g, 50 g.

Instructions for use and dosage regimen

Intramuscularly or intravenously. Magnesia is used only as prescribed by a doctor. Doses are adjusted taking into account the therapeutic effect and the concentration of magnesium sulfate in the blood serum.

For hypertensive crises, 5-20 ml of a 25% solution is administered intramuscularly or intravenously. At convulsive syndrome In spastic conditions, the drug is prescribed intramuscularly, 5-20 ml of a 25% solution in combination with anxiolytic agents that have a pronounced central muscle relaxant effect.

At acute poisoning mercury, arsenic, tetraethyl lead are injected intravenously in 5-10 ml of a 5-10% solution of magnesium sulfate.

Side effect

bradycardia;
diplopia;
sudden rush of blood to the face;
headache;
decrease in blood pressure;
nausea, vomiting;
diarrhea;
flatulence;
thirst;
dyspnea;
slurred speech;
weakness;
decreased or loss of deep tendon reflexes;
depression of the respiratory center;
cardiac conduction disturbance;
heart failure;
hyperhidrosis;
anxiety;
pronounced sedative effect;
polyuria;
uterine atony;
electrolyte imbalance ( increased fatigue, asthenia, confusion, arrhythmia, convulsions).

Contraindications

severe chronic renal failure;
hypersensitivity to magnesium sulfate;
appendicitis;
rectal bleeding (including undiagnosed);
intestinal obstruction;
dehydration;
arterial hypotension;
depression of the respiratory center;
severe bradycardia;
AV block;
prenatal period (2 hours before birth).

Use during pregnancy and breastfeeding

During pregnancy, Magnesia is used with caution, only in cases where the expected therapeutic effect outweighs the potential risk to the fetus.

If necessary, use during lactation breast-feeding should be stopped.

special instructions

Take orally or administer parenterally with caution in case of heart block, myocardial damage, chronic renal failure, respiratory diseases, acute inflammatory diseases Gastrointestinal tract, pregnancy.

Magnesia can be used for cupping status epilepticus(as part of complex treatment).

In case of overdose, it causes depression of the central nervous system. Calcium preparations - calcium chloride or calcium gluconate - are used as an antidote for an overdose of magnesium sulfate.

Drug interactions

With parenteral use of Magnesia and simultaneous use peripherally acting muscle relaxants, the effects of peripherally acting muscle relaxants are enhanced.

With simultaneous ingestion of antibiotics from the tetracycline group, the effect of tetracyclines may decrease due to a decrease in their absorption from the gastrointestinal tract.

A case of respiratory arrest during the use of gentamicin in an infant with an increased concentration of magnesium in the blood plasma during therapy with magnesium sulfate is described.

When used simultaneously with nifedipine, severe muscle weakness is possible.

Reduces the effectiveness of oral anticoagulants (including coumarin derivatives or indanedione derivatives), cardiac glycosides, phenothiazines (especially chlorpromazine). Reduces the absorption of ciprofloxacin, etidronic acid, weakens the effect of streptomycin and tobramycin.

Calcium preparations - calcium chloride or calcium gluconate - are used as an antidote for an overdose of Magnesia.

Pharmaceutically incompatible (precipitate forms) with calcium preparations, ethanol (alcohol) (in high concentrations), carbonates, bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, procaine hydrochloride, salicylates and tartrates.

Analogues of the drug Magnesia

Structural analogues of the active substance:

Cormagnesin;
Magnesium sulfate;
Magnesium sulfate Darnitsa;
Magnesium sulfate solution for injection.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

Magnesia is a well-known pharmaceutical drug with a wide range of uses and excellent performance indicators. To be able to evaluate the benefits that this medicine can bring, you need to read the instructions for use of the drug magnesia.

Magnesia is used both for the relief of acute pathological conditions and in combination long-term therapy chronic diseases.

Release form and composition

Magnesia – magnesium sulfate (magnesium salt of sulfuric acid) – chemical compound, which has the appearance of a whitish powder, is found in natural sea water.

Magnesium sulfate is commercially available in two forms: dry form(powder, briquettes) and wet form (injection).

The powder is produced without any auxiliary substances; the solution also contains water for injection, which acts as a solvent for magnesium powder.

The powder is available in 5g and 10g packages. and 25 g., used for oral administration (inside).

The solution has a concentration of 25%, packaged in ampoules with a capacity of 5 ml. and 10ml.

Oral use of magnesia powder is recommended for diseases of the gastrointestinal tract. The drug helps with constipation, causing an influx of fluid through the walls of the small and large intestines, and has choleretic and antispasmodic effects. The detoxifying properties of magnesia are noted - the drug binds the toxic elements of certain metals and salts.

Excretion of magnesium by the kidneys provokes a relative diuretic effect.

Injection use of the drug can reduce blood pressure and prevent the development of convulsive syndrome.

Improves heart rhythm, dilates blood vessels, and has a mild sedative effect.

The use of magnesium sulfate is indicated for the following diseases and conditions:

magnesium deficiency
arterial hypertension, cerebral edema, hypertensive crisis, tachycardia
concussion, brain contusion, age-related or hormonal disorders nerve impulses in the brain, epilepsy
poisoning with barium compounds, heavy metal salts
constipation, biliary tract disorders, cholecystitis, formation of fecal stones
some dermatological diseases.

Magnesia in the form of powder or granules received wide application V professional sports to cleanse the body and additionally remove toxins.

The injection form is used in the form of intravenous or intramuscular injections. Intravenous use the drug allows you to achieve the expected result in 10-20 minutes, the result lasts up to two hours.

Intramuscular administration of magnesium allows you to evaluate the result after 40-60 minutes, the effect lasts about 4 hours.

For hypertensive crisis, convulsive status, adults are prescribed 5-20 ml of 25% magnesia solution intravenously in a stream, slowly. Patients note a feeling of heat spreading from the injection site throughout the body; the rate of administration should be controlled by the patient’s well-being.

For eclampsia, 10-20 ml of a 25% solution intravenously or intramuscularly.

For convulsions in children, a 20% solution of magnesium is administered, the dosage is calculated according to the principle of 0.1-0.3 ml/kg of the child’s weight, the drug is administered intramuscularly.

Powder for oral use is diluted with drinking water and taken in certain dosages:

biliary dyskinesia– 20g of the drug + 100ml of water. 1 tablespoon, 3 times a day, 10 minutes before meals
constipation– 20-30g magnesia powder +100ml water. Drink the entire contents at night or on an empty stomach. It is not recommended to repeat the procedure more often than once a month. The same solution is available for use in the form of warm enemas.
poisoning– 20 grams of the drug per 200 ml of water, orally, 1 time per day.

Magnesium sulfate is serious drug, its use is possible only as prescribed by a doctor in strictly prescribed dosages. But even in this case there is a possibility individual reaction for magnesium preparation.

The manifestations of this phenomenon are varied, symptoms can be caused by disruptions in work various systems organs:

From the digestive system – nausea, vomiting, diarrhea, bloating, heartburn
From the nervous system – dizziness, fatigue, disturbances of consciousness, headache
From the cardiovascular system - arrhythmia, bradycardia, anxiety, hot flashes.

Suspicion of bleeding in any part of the gastrointestinal tract makes the use of magnesia powder internally impossible.

Among other gastrointestinal diseases, in which oral administration A drug such as magnesia is contraindicated, isolated: intestinal obstruction, foreign body in any part of the gastrointestinal tract, appendicitis, exacerbation of a stomach ulcer.

If you are dehydrated, magnesium should not be used internally.

The injection solution is contraindicated for use in patients with low blood pressure and symptoms of respiratory failure. Impaired kidney function can lead to irreversible consequences after using the drug.

If there are warning signs of labor or while waiting for the onset labor activity It is not recommended to inject the drug.

The phenomena of hypermagnesemia - an excess of magnesium in the patient's body, are an absolute contraindication to the prescription of treatment with magnesium powder or solution.

Violation of the dosage of drug administration or incompetent administration of magnesia can lead to an overdose.

The first symptoms of a pathological increase in magnesium concentration are:

reduction in blood pressure to 90/50mm. rt. Art.;
headache, dizziness;
weakness in the limbs, shortness of breath;
nausea;
diction violations.

If compensatory therapy has not been started, the symptoms of a drug overdose will worsen and add the following signs:

heart rate slows down to 40-50 beats/min
depression, slow reflexes
stopping breathing, heartbeat
pathological acceleration of diuresis.

A patient with these symptoms should be urgently hospitalized in the department intensive care. Active therapy with calcium supplements is started.

The use of the drug is permitted during pregnancy; its use is widely used in two conditions:

threat of miscarriage or premature birth (the drug helps relax the muscles of the uterus, neutralizes tone)
prevention of seizures and lowering blood pressure in eclampsia

The use of the drug in the correct dosage does not cause any harm to either the mother or the fetus, but an overdose can be fatal.

Associated effects of using magnesia during pregnancy are an anti-edematous effect and relief from constipation.

The vasodilating, resolving effects of magnesium sulfate make the drug effective in the treatment of warts or papillomas.

For external treatment For warts, it is recommended to use compresses made from diluted magnesia powder or electrophoresis with this drug.
Using the powder internally promises to get rid of pathological growths on the skin, but you must remember the accompanying laxative effect.

Recipe:

To prepare a compress, dilute 20 magnesia preparation powder in 0.5 l. water.
Apply the moistened gauze pad to the affected area.
The exposure time of the drug is 10-15 minutes.
It is recommended to repeat the procedure twice a day for 2-3 weeks.

The wart should gradually dry out and fall off.

For electrophoresis with magnesium at dermatological diseases It is recommended to consult a physiotherapist, he will prescribe the necessary treatment regimen.

Storage temperature 10-25o.

An open bag of powder is stored no more than 48 hours.

The drugs are stored without damage to the original packaging, subject to climatic standards:

powder – 5 years;
injection solution – 3 years.

In Ukraine, 25g of magnesia powder will cost 6-8 UAH (18-25 rubles), 10 ampoules of 5 ml of 25% solution - 12-15 UAH (36-45 rubles).

In Russia, the price for 25g of powder is 25-40 rubles, 10 ampoules of 5 ml of the drug are 30-45 rubles.

The drug Magnesia is a magnesium salt of sulfuric acid, it is also known as “magnesium sulfate” and “Epsom salt”. IN medical practice Magnesia has been used for several decades and is successfully used in many fields: neurology, cardiology, gastroenterology, obstetrics and gynecology. Magnesia is very popular for weight loss and cleansing the body.

Magnesium sulfate also appears in the sports industry. All aspects of the use of Magnesia, reviews of the effectiveness of this drug, detailed and reliable information about the price, forms of release, dosage, possible side effects and contraindications are presented further on this page.

Instructions for use of magnesia

Treatment with magnesia

Magnesia for children

Magnesia during pregnancy

Tubazhi with Magnesia

Magnesia for weight loss

Physiotherapy with Magnesia

Mineral water "Magnesia"

Sports Magnesia

Reviews of Magnesia

Magnesia: price and release form

Instructions for use of magnesia Pharmacological action of magnesia

The drug Magnesia (magnesium sulfate) has the following types of effects on the human body (in descending order of severity):

Laxative;

Choleretic;

Antispasmodic;

Tocolytic;

Vasodilator;

Analgesic;

Anticonvulsant;

Antiarrhythmic;

Diuretic;

Hypnotic.

This is important: High doses of Magnesia when administered intravenously can have an effect similar to that of taking narcotic substances from the group of opiates, namely: inhibition of consciousness, disorientation, fainting, hallucinations.

The speed of onset of the therapeutic effect, its type and duration depend on the method of taking Magnesia:

Orally, the laxative and choleretic effect of the drug begins after three hours and lasts for six hours;

Intramuscular - relaxation of smooth muscles occurs after one hour and lasts up to four hours;

Intravenously - the antispasmodic effect occurs almost instantly, but disappears after half an hour.

The laxative effect of magnesium sulfate is explained by its ability to thin and increase the volume of stool, as well as promote an increased flow of water into the intestines. The choleretic effect is achieved by reducing the muscle tone of the duodenum and simultaneous irritation of the mucous membrane lining it.

Since Magnesia is partially evacuated from the body by the kidneys, it manages to cause an influx of fluid to them and serve as a weak diuretic. There is a practice of using Epsom salts for poisoning with heavy metals and poisons: arsenic, mercury, lead. In this case, Magnesia’s ability to enter into chemical reaction with hazardous substances, bind them and quickly remove them from the body.

Magnesium sulfate is actively used in physiotherapy for therapeutic baths and electrophoresis. Such procedures have a pronounced antispasmodic, analgesic, vasodilating and calming effect on the patient’s body. Topical application of Epsom salts as compresses and lotions helps eliminate warts, heal wounds, and reduce psoriatic manifestations.

Sports magnesia is a special powder for treating the hands of athletes interacting with various equipment: barbells, crossbars, uneven bars, spears, discs, rings. The fact is that magnesium sulfate has a pronounced anti-slip effect when applied to the skin of the hands, due to which sports equipment is securely fixed.

Indications for use of magnesia

Magnesia is used to treat the following diseases and pathologies:

In neurology - epilepsy, cerebral edema, increased nervous excitability, encephalopathy, convulsive syndrome;

In cardiology - hypokalemia and hypomagnesemia (deficiency of potassium and magnesium in the body), ventricular arrhythmia, tachycardia;

In therapy - poisoning with salts of heavy metals, bronchial asthma, increased sweating, urinary retention, warts, wounds and infiltrates;

In gastroenterology – dyskinesia biliary tract, constipation, cholecystitis;

In obstetrics and gynecology – preeclampsia and eclampsia, threat of premature birth.

Find out more: Magnesium to lower blood pressure

Interaction of magnesium with other drugs

Magnesia may interact with some other medications, especially when given by injection or drip administration:

Muscle relaxants – enhances their effect;

Anticoagulants, cardiac glycosides, phenothiazine - weakens their effects;

Nifedipine – causes severe muscle weakness;

Tobramycin and Streptomycin - reduces their antibacterial effect;

Ciprofloxacin - enhances the effect of this antibiotic;

Tetracyclines - reduces absorption from the gastrointestinal tract and reduces their effectiveness.

Magnesium sulfate is absolutely incompatible with the following substances:

Arsenic salts;

Phosphates, carbonates and bicarbonates of alkali and alkaline earth metals (potassium, barium, strontium);

Tartrates (salts and esters of tartaric acid);

Salicylates (salts of salicylic acid);

Antibiotics of the lincosamide group (Lincomycin and Clindamycin);

Novocaine;

Hydrocortisone.

This is important: In case of overdose or poisoning with Magnesia, gluconate or calcium chloride is used as an antidote.

Treatment with magnesium How to take Magnesia orally?

For oral administration or rectal administration, a suspension is prepared from warm boiled water and magnesium sulfate powder.

The proportions depend on the patient’s age and treatment goals:

Magnesia laxative – 10-30 g of powder per half glass of water (100 ml). Take the entire volume of the suspension once on an empty stomach, in the evening before bed or in the morning immediately after waking up. Do not eat anything until you have a bowel movement (usually 1-3 hours). To enhance the laxative effect, you can additionally drink 2-3 glasses of warm boiled water;

Magnesia choleretic – 15-25 g of powder per half a glass of water (100 ml). Mix thoroughly and take 1 tablespoon 3 times a day immediately before meals;

Enema with Magnesia – 40-60 g of powder per 200 ml of water. Used to treat severe chronic constipation when oral magnesium sulfate is ineffective;

Duodenal intubation with Magnesia - 10-50 ml of a solution of 10% or 25% concentration is injected into duodenum through a probe.

This is important: Magnesia is an emergency laxative; it is not suitable for daily regular use for chronic constipation, since it has a strong irritant effect on the mucous membranes of the gastrointestinal tract.

Magnesia intravenously and intramuscularly

If magnesium sulfate is used as a muscle relaxant or a drug that lowers blood pressure and normalizes heart rate, it is advisable injection. For injections and droppers, use a ready-made 25% solution of Magnesia in ampoules. Intramuscular injections do not require a decrease in the concentration of the active substance, and for intravenous and drip administration the drug is diluted with 5% glucose or saline, since the immediate entry into the bloodstream of undiluted Magnesia can cause an unpredictable violent reaction in the body and provoke complications.

Intramuscular injection of magnesium sulfate is accompanied by severe pain. Intravenous and drip administration of the drug is characterized by patients as quite tolerable, but at first a burning sensation is usually felt, spreading through the vein and gradually fading. The medical personnel performing the injection are obliged to warn the patient in advance about the need to carefully monitor their well-being after the administration of Magnesia. If symptoms such as dizziness, redness of the face, or tightness in the chest occur, you should immediately report them to your doctor. After removing the Magnesia drip, a control measurement of blood pressure and pulse is always performed.

Maximum dosage of Magnesia

For an adult, the maximum permissible single dose of magnesium sulfate for oral administration is 30 g. For intramuscular or intravenous administration, the limit is 200 ml of a 25% solution per day.

Magnesia for children

Treatment of constipation with Epsom salts has no age-related contraindications; it is only necessary to correctly calculate the dosage of Magnesia for children. For adolescents over 14 years of age, prepare a suspension of 100 ml of warm boiled water and 15-30 g of magnesium sulfate powder, and to find out how much Magnesia can be given to a younger child, use the following formula.

This is important: How old is the baby, so many grams of magnesium sulfate powder should be used to prepare a laxative, for example: 5 years = 5 g of Magnesia + 100 ml of warm boiled water.

If your child is severely constipated, you can give him an Epsom salt enema. Depending on the age and weight of the baby, you will need from 50 to 100 ml of Magnesia solution. A concentration of less than 20 g of powder in such a volume of warm water will not have a therapeutic effect when administered rectally, however, it is not necessary to put more than 30 g in half a glass of water, otherwise irritation of the delicate mucous membrane of the children's intestines will occur.

Intramuscular or more often intravenous administration of Magnesia to children is used in cases of critically high intracranial pressure or suffocation. The drug is even used to treat birth asphyxia in newborn babies, so we can once again say with confidence that Magnesia is safe and has no age-related contraindications.

Magnesia during pregnancy

During pregnancy, magnesium is used as an effective muscle relaxant, that is, a remedy that relaxes smooth muscles and relieves spasms. Uterine hypertonicity is a common cause of spontaneous abortion and premature birth. If the muscles of this organ are too tense and their wave-like contractions are observed, which are undesirable for early date gestation and can lead to premature shortening of the cervical canal, dilatation of the cervix and expulsion of the fetus, the doctor may prescribe intravenous or intramuscular administration of Magnesia to the pregnant woman. Injections are carried out strictly in a hospital under the close supervision of medical staff and with careful monitoring of the patient’s blood pressure and pulse.

This is important: The concept of “uterine hypertonicity” has been discredited by the modern gynecological community. This organ must have a high muscle tone for a successful birth, and periodic contractions of the uterus normally do not threaten the normal course of pregnancy.

Therefore, measures to remove increased tone smooth muscles of the uterus during pregnancy, including the use of Magnesia, must have good reasons: for example, a history of miscarriage or premature birth, pain in the lower abdomen and lower back, bloody issues from the genital tract. Any pathological symptoms during pregnancy should be carefully diagnosed, and almost everyone in our country receives an ultrasound report with the outdated wording “hypertonicity of the uterus” future mom, and often without any reason.

Another important limiting aspect of the use of Magnesia during pregnancy is that magnesium sulfate enters the placental bloodstream and can depress the respiratory and cardiac function of the fetus. How later date gestation, the greater the volume of blood penetrates through the umbilical cord from the mother to the unborn child, respectively, the stronger Magnesia affects his body. Therefore, magnesium sulfate is used in the last trimester of pregnancy only for special indications, and a few hours before the expected birth, administering this drug to a woman is completely prohibited.

The diuretic effect of Magnesia, which is used by some gynecologists as part of the treatment of preeclampsia and eclampsia in pregnant women, deserves special mention. In this case, the administration of magnesium sulfate is carried out by drip, very slowly, under constant monitoring of the vital signs of the expectant mother and fetus.

Tubazhi with Magnesia

Tubage is a cleansing procedure that is designed to increase the flow of bile through the ducts, eliminate congestion in the gallbladder and prevent the formation of stones in it, that is, the development of cholelithiasis. Tubage can be done not only in a hospital, but even at home on a regular basis, but only as prescribed by the attending physician and after thorough examination body. Indications for such treatment are biliary dyskinesia and bile stagnation.

Contraindications for tubing:

Intestinal obstruction;

Rectal bleeding;

Appendicitis;

Gallstones;

Dehydration of the body;

Low blood pressure;

Hypermagnesemia;

Exacerbation of any chronic disease;

An infectious process in the body, accompanied by a febrile syndrome.

For tubage, Magnesia is used in powder form: 1 tablespoon per glass of warm water. The mixture must be thoroughly stirred and drunk whole, and then lie on your right side, place a heating pad under the liver area and lie there for about an hour and a half. The procedure is considered successful if after tubing the first stool excreted has a greenish tint, that is, it contains bile. Treatment with Magnesia in the form of tubes can last up to 15 weeks in a row - one procedure every week, unless otherwise prescribed by a doctor.

Before starting therapy, you need to adjust your diet: exclude fatty, spicy, pickled, smoked and canned food. The basis of the menu should be porridge (except semolina, millet and pearl barley), soups, vegetable stew, boiled or baked chicken or lean fish, in a word, easily digestible and healthy dishes. It is recommended to follow a gentle diet throughout the entire course of treatment, but be especially careful on the day the tubing procedure is performed. After it, doctors advise eating some grated carrots with an apple or a salad of boiled beets with vegetable oil.

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Magnesia for colon cleansing

Epsom salt colon cleansing is another popular home remedy. However, it can be done, like tubage, only after consultation with a doctor. As we mentioned above, magnesium sulfate has an irritating effect on mucous membranes and is not suitable for regular use. Therefore, colon cleansing with Magnesia should not be done more than once a month. Strictly speaking, two or three episodes are enough for a person similar procedures per year to maintain the intestines in in good condition with a tendency to constipation.

With age, in all people, even those who do not have problems with stool, hard concrements – fecal stones – stick and accumulate on the walls of the colon and rectum. They make it difficult for feces to pass through the intestines and serve as a constant source of toxic substances and breakdown products entering the bloodstream. All this leads to the development of allergies, spoils the complexion and provokes constipation. To eliminate fecal stones, they need to be softened, and for this, magnesium sulfate is ideal, as it foams the shaft, increases its volume and quickly removes it from the body.

Intestinal cleansing Magnesium is carried out using an enema: take 30 g of powder per 100 ml of warm boiled water, mix thoroughly and inject the resulting solution into the anus, and then lie on your side with your legs tucked under you until the urge to defecate ceases. expressed. Complete emptying intestines occurs approximately an hour after an enema with Magnesia. Cleansing is carried out in a short course, 2-5 procedures per week (the exact number is determined by the doctor based on diagnostic data about the patient).

If we consider the effectiveness of intestinal cleansing with Magnesia, the reviews are mostly positive - the state of health improves, the stool is normalized, there are no side effects. But regarding the safety of this method of cleansing the body, doctors disagree: representatives of the “old school” actively recommend Magnesia as a laxative and a means for performing enemas, while young specialists talk about the too aggressive effect of magnesium sulfate on the intestinal walls and suggest other, more modern and gentle drugs.

When unstable it is considered an excellent remedy, helping to provide a lasting vasodilator effect.

Since this phenomenon is observed with frequent depression, nervous overstrain, negative emotions, during pregnancy and menopause, you must always be prepared for a change in the state of the body.

It is characterized by such unpleasant symptoms as dizziness, tinnitus, rapid heartbeat, nausea and in rare cases vomit. So is it allowed to administer a drug like Magnesia? Why is it prescribed intramuscularly and how to inject Magnesium sulfate intramuscularly?

This medicinal product refers to vasodilating agents and has a colossal number of positive therapeutic effects. But is it possible to take magnesium intramuscularly?

The drug can be used either orally or administered by injection. Experts recommend doing this intramuscularly.

Magnesium sulfate in ampoules

The product is available in the form of a regular injection solution and in the form of a fine powder from which a suspension is prepared. The latter can be bought in packaging. Its weight varies: 10 g, 20 g, 25 g and 50 g. But ampoules with the solution are produced in the following volumes: 5 ml, 10 ml, 20 ml and 30 ml.

The medicine also has another name - Magnesium sulfate. The concentration of the active substance can be 20% or 25%. Regarding the question of whether Magnesium sulfate can be administered intramuscularly, the answer is positive.

However, we must not forget that injections of this substance are quite painful, so some experts prefer to use intravenous administration. To significantly reduce pain, you need to mix the drug with Novocaine. The doctor selects the dose individually, depending on the indications.

Magnesia is used for high blood pressure intramuscularly, as well as for epileptic seizures, poisoning with heavy metal salts, urine retention.

The injection of Magnesia intramuscularly is given quite deeply, it is for this reason that the syringe needle must be long. The introduction should be carried out very slowly.

If Novocaine is used for maximum pain relief, then it is combined with the drug in one container and the resulting solution is drawn into a syringe. For one ampoule with a concentration of the active substance of 25%, you need to take approximately one part of Novocaine 2%. It is not recommended to practice self-administration of the medicine, as this can lead to serious consequences.

To ensure that Magnesia injections intramuscularly are safe, you should trust a professional.

Indications for use

The drug is used for many pathologies because it has big amount positive properties:

helps eliminate neuroses, excitement, irritability, aggressiveness and anxiety. It has a powerful sedative effect. With a slight increase in the indicated dosage, the effect of the drug is observed as in sleeping pills;
helps remove unnecessary fluid accumulated in the body. Thanks to this, you can get rid of swelling of the face and body;
lowers blood pressure;
relaxes muscle tissue artery walls. This is what helps the vessels expand so that blood can circulate freely in them;
eliminates convulsive phenomena in the upper and lower extremities;
reduces pain caused by muscle spasms;
minimizes the excitability of myocytes and also returns to normal indicators ionic equilibrium.
prevents the formation of blood clots in the arteries and protects cardiovascular system from various injuries;
improves blood supply to the vessels of the uterus due to their expansion. In addition, the contraction of her muscles is inhibited;
helps eliminate signs of poisoning of the body when metal salts enter it.

Intramuscular magnesium has the following indications for use:

with visible symptoms of cerebral edema;
convulsions in eclampsia, as well as in severe preeclampsia;
strong contractions of the uterine muscles;
polymorphic ventricular tachycardia;
magnesium deficiency;
acute hypomagnesemia;
heavy metal poisoning.

If we consider the oral use of this drug, we will be able to achieve a strong laxative effect, since with this type of use it is not absorbed into the systemic bloodstream.

The main recommendations for why Magnesia is injected intramuscularly are the following diseases and conditions:

problems with stool;
cholecystitis and cholangitis;
duodenal intubation;
dyskinesia of the gallbladder during tubing;
cleansing the intestines to diagnose its condition.

An overdose can provoke apathy, impairment respiratory function, as well as drowsiness. Some who have tried the Magnesia injection call it “hot”, since the patient at this moment feels the gradual spreading of the substance throughout the body. There is warmth, sometimes a strong burning sensation.

How to properly inject Magnesia intramuscularly?

Magnesia is used for pressure intramuscularly at a dosage of 25% solution of the drug, which is available in ampoules.

Before injecting Magnesia intramuscularly under pressure, the solution does not need to be further diluted.

As a rule, such an injection is quite difficult to tolerate, since it is accompanied by severe, unbearable pain. Immediate administration of the medicine may cause seizures.

If you do this inside the muscles, the product begins to have its effect within 30 minutes. Positive effect can persist for several hours.

To carry out the procedure, you need to acquire a long and thin needle. The ampoule must first be warmed up a little and the injection site treated with a special disinfectant solution.

With a quick movement of the hand, the needle is inserted into a certain place until it stops and only after that it is gradually and smoothly released from the syringe medicinal composition. It is not recommended to allow the product to stagnate in the muscles.

The injection must be carried out by a medical professional, since this way you can avoid the solution getting into small blood vessels, which is extremely undesirable.

Dosage

Magnesia is used intramuscularly at pressure with a dosage of 25% ampoule solution.

It is important to remember that the largest single dose of Magnesia at intramuscular pressure is 200 ml of a 20% solution.

As for the use of medicine for children, with the method under consideration it is prescribed for the immediate relief of emergency conditions, such as: severe asphyxia, high blood pressure inside the skull. In case of such dangerous phenomena, the drug can be prescribed even to infants.

It is also used to treat ailments in pregnant women. As a rule, the most common indication for use is uterine hypertonicity. To eliminate this pathological condition an appropriate dosage of Magnesia is required, which is prescribed by the attending physician. This measure is urgent in conditions such as the threat of miscarriage or the risk of premature birth.

It is advisable to carry out an intramuscular injection in a hospital setting under the supervision of a personal specialist. This is due to the fact that the drug can cause respiratory depression and an unexpected drop in blood pressure in the baby.

Because of probable complications the medication solution should be stopped administered approximately a few hours before possible delivery.

Due to its strong diuretic effect, Magnesia can be used during pregnancy to reduce swelling (for example, with preeclampsia and eclampsia). In this case, the solution itself can be administered through a dropper.

The duration of its use is absolutely individual. In some cases, it is prescribed once to improve the condition of the expectant mother. However, only the attending physician can determine the duration of therapy.

Before administering Magnesia intramuscularly, you must ensure that there are no following contraindications:

bradycardia;
visual impairment;
instant rush of blood to the face;
Strong headache;
slurred speech;
urge to vomit;
weakness and drowsiness.

Contraindications for the use of Magnesium sulfate include:

stones in the bile ducts;
presence of intestinal obstruction;
tendency to a sharp drop in blood pressure;
high concentration of magnesium in the blood;
exacerbation of certain chronic diseases;
attack of appendicitis;
first trimester of pregnancy;
lactation.

The indication for use of the drug during an increase in blood pressure is a hypertensive crisis. Therefore, in this condition, only doctors can inject this drug.

However, many modern specialists completely refuse to use Magnesia for hypertension. They explain this by the fact that the drug has the ability to significantly lower blood pressure, and not bring it back to normal.

It should be noted that after intramuscular administration of the drug, infiltrates can form, which disappear quickly with timely treatment and do not cause any complications.

Video on the topic

Is Magnesia effective for high blood pressure intramuscularly and how to give the injection correctly? Answers in the video:

From all the information presented in this article, we can conclude that a drug called Magnesia is highly effective in this dangerous condition like a hypertensive crisis. Only the attending physician can administer treatment through intramuscular injections.

If you have high blood pressure, use extreme caution as the medicine can significantly lower your blood pressure levels. In some cases, even to a critical point. There is no need to self-medicate and inject medication into muscle tissue.

Why are Magnesia injections prescribed?

Magnesia or magnesium sulfate is a drug that provides a wide range of beneficial effects on the body. It is recognized in the pharmaceutical market and has good feedback. The medication is used against a number of pathological diseases. Let's look at what pharmaceuticals help with and why they are prescribed by doctors.

Medicinal effect of injections

Intramuscular and intravenous administration allows achieving a hypotonic, sedative, vasodilating effect. In addition, the product relieves existing convulsions and arrhythmia.

After intravenous use, the effect occurs within a few seconds and up to half an hour, while when the medication enters the muscle, the effect occurs after about 60 minutes and retains its ability for 3-4 hours.

When administered intramuscularly, the drug begins its effect after 1 hour. Its duration reaches 3–4 hours, and when administered intravenously, it acts in a matter of seconds and remains active for up to half an hour.

Indications for use

Magnesia injections are indicated in the fight against a number of ailments, in particular:

Edema of the brain and its organic lesions;
Epileptic seizures;
Lack of magnesium in the circulatory system;
Ventricular arrhythmia;
Severe nervous overexcitation;
Excessive sweating;
Hypotonic dyskinesia of the bile ducts;
Cholecystitis;
Asthma of bronchial type;
Heavy metal poisoning;
Difficulties in the process of emptying and urine retention.

Contraindications

Low blood pressure;
Problems with cardiac impulses;
Heart rate abnormalities;
Carrying a child;
Appendix;
Bleeding from the anus;
State of dehydration;
Obstruction of the intestines and feces;
Obvious pathologies of the renal system.

Use during pregnancy and lactation

Based on the rules for receiving the studied pharmaceutical product, it is not indicated in the prenatal period. However, in some situations, under strict medical supervision, this measure is sometimes necessary. In this case, the dosage form is indicated exclusively for injection.

Magnesia is used to relax the smooth muscles of the uterus, preventing miscarriage or childbirth earlier than expected. The danger of use is associated with the penetration of the active elements of the medication into the woman’s blood, and therefore into the fetus. In this situation, they can provoke respiratory disorders and low blood pressure in the unborn child. Use the medication several hours before possible process childbearing is unacceptable.

The injections can help provide a diuretic effect that reduces the swelling of the limbs that the fair sex suffers from when carrying their unborn baby.

The role of doctors in this period is extremely important. They are entrusted with the responsible role of monitoring female body in the situation and its reaction to the medication used.

Those who have already become mothers and are feeding their newborns with milk need to temporarily stop this process. Otherwise, it will harm the child and will be reflected during his development.

Special conditions of therapy

Simultaneous administration of other salts into the same vein should be avoided;
Epilepsy can be controlled only with combined treatment;
Patients with serious kidney problems should carefully monitor the dosage prescribed by the doctor and in no case deviate from it. Regular monitoring of body tests is also necessary;
The onset of the development of any side effects requires immediate refusal of treatment with the medical product in question;
The injection solution can be used orally to achieve a laxative reaction;
Increasing the dose can cause a narcotic, tocolytic and hypnotic effect;
Alcoholic beverages are not allowed during therapy.

Side effects

For the most part, the patient does not have any problems with assimilation of the active and other elements that help them. But occasionally there are some unpleasant situations:

Low heart rate;
Decreased blood pressure;
Arrhythmia;
Increased sweating;
Malfunctions of the central nervous system;
Feelings of anxiety, tension;
Migraine;
Hypermia of the facial skin;
Craving to vomit;
Decreased body temperature;
Excessive discharge of feces, their wateriness;
Excessive gas formation;
Spasmodic pain in the abdominal cavity.

Instructions for use of solution for injections

A 25% solution is usually administered intramuscularly. It is available in ampoules and does not require a special method of mixing with other components. May be painful when inserted.

It is administered intravenously both in diluted form - with sodium chloride or 5% glucose, or in pure form. In most cases, as doctors advise, it is better to dilute the solution. This is due to the fact that undiluted drug can cause a worsening of the clinical picture.

A maximum of 200 ml of solution (20%) can be administered per day.

Magnesia in childhood

It is often used in pediatrics to overcome constipation in minors. He copes with this trouble - safely. In this case, it is recommended to use the powder form of the medicine. The dose depends on age - from 6 to 12 years old, 6-10 grams per day is recommended; from 12 to 15 years – up to 10 grams per 24 hours; patients over 15 years old - from 10 to 30 grams per day.

To determine the most accurate dose per day, doctors advise using the formula - 1 gram multiplied by 1 year of life.

Another format of use is the introduction of a prepared solution of powder (20 grams) and purified water (100 ml) into the rectum by enema. It is enough to administer from 50 to 100 ml.

Injection of the solution (even to recently born children) is carried out exclusively in in case of emergency and severe indications.

Overdose condition

Use in increased quantities can cause a lot of negative reactions. These include violations respiratory processes, dysfunction of the central nervous system, up to coma.

Fortunately, there is an antidote - preparations containing calcium chloride and calcium glucanate. For more severe poisoning, artificial ventilation is used and symptomatic therapy is provided.

Compatibility of the drug with other drugs

Nifedipine, oral anticoagulants, cardiac glycosides - promote obvious muscle relaxation;
Phenothiazine reduces the effectiveness of the pharmaceutical product;
Tobramycin and Streptomycin– reduce antibacterial effect;
Ciprofloxacin– enhances the fight against bacteria;
Tetracycline-type antibiotics– worsen overall effect and absorption from the digestive tract.

Analogs of Magnesia

There is no complete substitute for the drug. Only the powder production form of the medicine is available for sale, which is taken orally.

It stands out for its high-quality choleretic and laxative effects on the body. The component composition of the medicine is not fully absorbed and creates an osmotic effect on the intestinal environment, due to which water accumulates in it, ensuring dilution of its contents. Begins to act in at least 30 minutes for a period of up to 6 hours.

It is shown mainly against hypertensive crisis, convulsive syndromes, as well as to overcome toxicosis in pregnant women. It is also sometimes prescribed, as part of complex treatment, to patients with epilepsy.

It is prohibited for persons with individual inability to absorb the medication, atrioventricular block, low blood pressure, as well as a lack of calcium in the body and problems with respiratory function. Not prescribed for patients with a tendency to myocardial infarction and other cardiac ailments, renal and hepatic failures, acute inflammation internal organs, responsible for digestive processes. Those who are carrying an unborn baby should drink the powder with extreme caution. Usually installed medical supervision and in cases where the expected useful action, will really be more effective and no less than possible harmful consequences. New mothers should stop breastfeeding while taking the drug.

Used as mentioned earlier - orally or by enemas. For adults, a multiple dose of 15 to 25 g a day before eating is enough. The powder dissolves in a glass of water with a volume of about 250 ml. For minors - over twelve years of age, it is recommended to take 10 g once a day in half a glass of water; at the age of 6 to 12 years, 5–10 g is prescribed. For those under six years of age, the dosage and regimen are established only according to the instructions of a specialist.

Use for body cleansing, compresses and baths

Magnesia in addition to its strengths pharmacological properties allows you to thoroughly cleanse the body, namely the digestive tract. These activities are carried out exclusively before entering the diet period and eating only healthy foods. The drug is used in the first days dietary nutrition. His active ingredient(magnesium sulfate) relieves general state, removes all toxins that are present in the body. Two schemes of use are recommended: 30 grams of powder is dissolved in half a glass of water and drunk before going to bed or at any time before meals, or the same dose is drunk in the morning after breakfast.

There is a practice of using it as warming compresses. They increase blood flow to the body, help relieve pain syndrome, have a beneficial effect on the resorption of existing seals. The compress is applied for up to 8 hours. After removal, the skin is washed with water, dried with a towel and lubricated with cream.

The medicine has another positive feature - doctors allow you to take baths with magnesium sulfate up to two times a week. They help remove psycho-emotional stress, improve general condition, overcome nervous conditions and recover after stressful situations. Also, toxins will be removed from the upper layers of the epidermis, and its condition will improve somewhat. To do this, you need to take warm water into the bath, pour about 100 g of the drug into it, as well as about 1 kg of salts - sea and table salts. You need to lie in it for up to half an hour.

How much do Magnesia ampoules cost - price at the pharmacy

The medical product does not have an exorbitant price and is available to many patients. The cost of the injection solution is on average 60 rubles, and the powder – from 20 to 30 rubles. Information about price tags for the drug under study was taken from leading online pharmacies in Russia. Sale - according to a prescription from the hospital.

Magnesium is a common drug used to treat magnesium deficiency. This microorganism is important for normal functioning and human health. The best effect is achieved by injecting the drug - intravenously or intramuscularly.

This drug is approved for use by both adults and children.

When administered parenterally, magnesia relieves convulsions, signs of arrhythmia, has a hypotensive effect and is very calming. At excessively high doses, the drug has a negative effect on the nervous and respiratory systems. Magnesium regulates the metabolic process, helps lower blood pressure and smoothes muscle tissue.
Indications for use:

Magnesium deficiency in the body.
Treatment of arrhythmia, as well as to get rid of attacks.
Prevention of arrhythmia.
Salts of heavy metals in the body.
Toxicoses of pregnancy in the third trimester.
Inability to bear a child.
In order to prevent premature birth.
Urinary retention.
Cramps.
In order to improve the effect of anesthesia.

The drug is contraindicated in a number of cases:

Individual intolerance to the main substance.
Disorders of the renal system.
Tuberculosis.
Tumors – benign and malignant.
Viral infectious diseases.

Injection for adults

Magnesia in ampoules can be used intravenously and intramuscularly. When administered into a vein, the effect occurs immediately, and when administered into a muscle, the effect occurs after 1 hour. A wide range of applications ensures the demand for this drug; the main range of activities is gynecology.

The method of administration is chosen by the doctor, but intramuscular injections are very painful. Therefore, when injecting, special thin and long needles are used, and novocaine is also often used.

Doses of the drug are determined individually, depending on the disease, the amount of magnesium in the body and other indicators.

In case of severe convulsive syndrome, 5-20 ml of 25% magnesia is administered, mixing it with painkillers. Injected into the muscle.
For hypertension or arrhythmia, 5-20 ml of a 25% solution is prescribed; injections can be done intramuscularly or intravenously. The drug is administered very slowly to relieve pain.
In case of severe poisoning with mercury, metal salts or arsenic, prescribe intravenous injections 5-10 ml of 5-10% solution.

Injection for children

Ampoules with magnesium solution are practically not used in pediatrics. Typically, this drug is prescribed to children in powder form as an effective means of combating constipation. In rare cases, injections are prescribed for serious pathologies.

For children from 6 to 12 years old, the dose of magnesium sulfate will be 6-12 grams per day
Children 12-15 years old – 12-15 grams per day
Adolescents over 15 years of age are prescribed 15-25 grams of magnesium per day

The drug is taken at one time. The dosage is such that 1 gram of the substance is consumed per 1 year of life. Up to 6 years of age, it is also possible to take magnesium, but it is carried out under the strict supervision of a doctor. The powder is always dissolved in water.

Many children take vitamin and mineral complexes that contain magnesium. To avoid an overdose of the drug, you must inform your doctor about taking minerals.

During pregnancy and lactation

Magnesium sulfate is actively used during pregnancy. It is prescribed only if the effectiveness outweighs the possible risk to the child. Taking magnesium helps prevent premature birth and reduces the risk of miscarriage.

Hypertonicity is excessive tension in the muscles of the uterus, which can lead to miscarriage. If signs of hypertonicity occur, magnesium is prescribed, taking it only under the strict supervision of a doctor, since in the event of an overdose, symptoms will occur in both the mother and the child. Magnesia is prescribed for gestosis and severe swelling and also for constipation.

For pregnant women, magnesium is administered intravenously - 5-20 ml of a 25% solution per 0.7-1 liter of injection solution. Injected very slowly, increased heart rate and breathing may occur, and hot flashes may occur. The drug has a pronounced diuretic effect.

If it is necessary to take magnesium during lactation, breastfeeding is stopped.

Women use this substance for effective and safe weight loss, as the drug has a pronounced diuretic and laxative effect. In this case, magnesium is used as an oral solution, or as a means for carrying out water procedures– dissolve the powder in water and take a bath.

If you missed an injection

Usually, doctors advise simply increasing the course of treatment by one day so that the patient’s body receives the full dose of the drug. A course of magnesium injections involves its daily use. In such a situation, under no circumstances should you double the dose of the drug during the next injection. The course of treatment should be continued with the same dosage.

Overdose - symptoms and what to do

If the level of magnesium in the blood exceeds, reflexes are impaired, the knee reflex may disappear - this is the first sign that occurs when the amount of magnesium in the plasma reaches 2-3 mmol/liter.
When the level of the substance reaches 3.5-5 mmol/liter, an expansion of the QRS is observed, this can be seen on the cardiogram, and bradycardia occurs. When the amount of the mineral in the body increases to 4-5 mmol/liter, vomiting, nausea, loss of strength, a sharp decrease in blood pressure, and speech impairment may also occur, hyperhidrosis and diplopia may occur.
A level of sulfate in the blood of 5-7 mmol/liter will lead to difficulty breathing and a deterioration in the pumping of blood by the heart. When the level reaches 12 mmol/liter, cardiac arrest is possible, as this substance has an intense effect on the central nervous system.

With a small but long-term overdose, depression and disappearance of reflexes may occur.

In case of overdose, an antidote – calcium salts – will help relieve symptoms. Calcium preparations are administered intravenously, the dose is 100-200 mg ionized calcium, administer it over 10 minutes. This will help with mild intoxication, if symptoms include fever, vomiting, allergic reaction, muscle hypotension.

In more serious cases, the antidote is reintroduced. When magnesium in blood plasma is 10-12 mmol/liter, apply symptomatic treatment, as well as methods such as artificial ventilation, hemodialysis or dialysis.

Side effects

During a course of injections, the following side effects may occur:

Bradycardia and depression of heart rate.
Sweating and hot flashes.
Anxiety and confusion.
Headache.
Diarrhea.
Severe attacks of thirst.
Disruption of the nervous system.

Combination with other medications

Injections cannot be combined with the following:

Alcohol, sleeping pills and anticonvulsants, as this enhances their effect. The combination with large doses of alcohol is especially dangerous.
The combination of a substance with analgesics and antihypertensive drugs– the functioning of the respiratory system is inhibited.
With cardiac glycosides, they increase the possibility of deterioration of cardiac conduction.
It cannot be combined with nifedipine and a muscle relaxant - this causes a blockade of muscle function.
With calcium supplements, it flushes magnesium from the body.

The article is for informational purposes only, before taking magnesia, consult your doctor.

Magnesia instructions

The instructions that accompany each package of Magnesia contain all the information necessary for the patient on its use and dosage regimen. Here you can read about the dosage forms of Magnesia and its composition, as well as read the indications for treatment.

In addition to the fact that the accompanying sheet contains information that warns about contraindications and side effects, there is guidance for use by various categories of patients.

If the drug Magnesia is prescribed for treatment, this instruction a must read.

Packaging and release form

The drug Magnesia is available in various dosage forms.

Magnesia powder

The drug in powder form is supplied to pharmacies packaged in ten, twenty or twenty-five grams. Magnesia powder is used to prepare the suspension.

Magnesia in ampoules

The drug in the form of a 25% solution is supplied to pharmacies in ampoules of five or ten milliliters. Each package contains ten ampoules.

Magnesia – magnesium sulfate

Magnesia, otherwise called magnesium sulfate or Epsom salt, does not contain impurities or auxiliary substances and consists only of magnesium salt of sulfuric acid. The drug is known for its effectiveness. Magnesia has been successfully used in gynecological, neurological, gastroenterological and many other medical fields.

The drug has wide range actions:

Dilates blood vessels;
Produces an analgesic effect;
Has a relaxing effect on the smooth muscles of the uterus;
Has an anticonvulsant effect;
Eliminates arrhythmia;
Has a weak diuretic effect;
Is a sedative;
Has a choleretic effect;
Relaxes.

However, it should be taken into account that the manifestation of the properties of Magnesia directly depends on the method of entering the drug into the patient’s body.

Orally

Within half an hour after taking the drug in the form of a suspension, a laxative and choleretic effect may occur, which can last up to six hours. The suspension can also be used to achieve a mild diuretic effect, since its excretion is partially carried out by the kidneys.

Also, the Magnesia drug in this dosage form can be used as an antidote to mercury, lead, barium salts and arsenic.

Intravenously and intramuscularly

Administration of the drug by intravenous or intramuscular injection can provide anticonvulsant and sedative effects, as well as dilate blood vessels and eliminate arrhythmia. However, if the drug is administered into large doses Tocolytic, hypnotic and narcotic-like effects may be caused.

The drug administered intramuscularly begins to show its effectiveness after about an hour, followed by a duration of up to four hours. Intravenous administration provides instant action, however, its duration is no more than half an hour.

Electrophoresis

Magnesia solution is used for therapeutic procedures, such as electrophoresis, medicinal baths and compresses, which are applied topically to the wound surface of the skin. Such sessions are indicated to achieve a calming and vasodilating effect. Sometimes warts are treated this way.

Locally

With compresses and dressings using Magnesia, tissue blood flow improves and an analgesic and absorbable effect is achieved.

Magnesia indications

The drug is indicated for use by those patients who need help with the following diseases and conditions:

With cerebral edema;
For encephalopathy;
For epilepsy;
For eclampsia;
If there is a threat of miscarriage or premature birth;
In a state of magnesium deficiency in the blood;
For ventricular arrhythmias, when the concentration of magnesium and potassium in the blood is too low;
With excessive nervous excitability; (epilepsy, increased mental and physical activity, convulsions);
To eliminate excessive sweating;
For hypotonic dyskinesias of the bile excretion pathways;
For cholecystitis;
For duodenal intubation;
If you have bronchial asthma;
In case of poisoning with any type of heavy metals;
If constipation occurs;
With urinary retention;
For the treatment of warts and wound surfaces.

Contraindications

The drug Magnesia has a number of contraindications that must be taken into account when prescribing it for treatment. So, it is not advisable to prescribe Magnesia to those patients who have a similar diagnosis:

With arterial hypotension;
With atrioventricular block;
With severe bradycardia;
If depression of the respiratory center occurs;
For women during the postpartum period;
If you have appendicitis;
In a condition with severe renal failure;
If there is rectal bleeding;
In a state of dehydration;
In the presence of intestinal obstruction.

Magnesia instructions for use

When the drug is prescribed as an anticonvulsant, as well as for hypertension and heart rhythm disorders, it is used by intramuscular or intravenous injection.

Magnesia intramuscularly

Magnesia is administered intramuscularly in the form of a 25% solution, which does not require additional dilution. This method of taking the drug is usually accompanied by painful sensations.

Magnesia intravenously

Magnesia is administered intravenously, as in the form of undiluted ready solution, and using its dilution with a solution of sodium chloride or glucose 5%. However, given the fact that complications can occur with rapid simultaneous administration of the drug, the injection solution is almost always diluted.

A maximum of 200 milliliters of a 20% solution can be used per day to administer Magnesia to a patient by any injection route.

Magnesia for children

IN childhood Magnesia is used mainly to treat constipation. Reception is carried out in the form of a suspension, which is obtained from the powder by diluting it in half a glass of warm water.

Children from 6 to 12 years old are prescribed from 6 to 10 grams per day;
children from 12 to 15 years old are prescribed 10 grams per day;
adolescents over 15 years of age are prescribed from 10 to 30 grams per day.

The dose of the drug can be determined independently as follows: 1 year multiplied by 1 gram. For example, for an eight-year-old child, a dose of eight grams should be determined.

Medicinal enemas may also be prescribed to treat constipation. To prepare them, you need to take 30 grams of Magnesia powder and mix it with half a glass of warm water after boiling it. The resulting solution in the amount required by age (from 50 to 100 milliliters) is administered to the anus.

When there is an urgent need for cupping emergency(severe asphyxia or intracranial hypertension), the child may be prescribed the drug intravenously or intramuscularly.

Magnesia during pregnancy

When a pregnant woman is at risk of miscarriage or there is a risk of premature birth, she is prescribed Magnesia to help relax the smooth muscles of the uterus.

The prescription involves administering the drug by injection with the obligatory condition that the woman is in the hospital under medical supervision. Since the drug has the ability to pass the placental barrier, medical personnel will monitor the condition of the fetus during its administration.

By slowly injecting a solution of Magnesia into a pregnant woman, swelling can be reduced due to the fact that the drug has a diuretic effect.

Magnesia injections

For many years, the drug Magnesia was considered one of the ideal remedies for the treatment of tetanus. In addition, it was used for anesthesia. This is due to the fact that the drug is capable of activating the effect of narcotic substances on the body.

When the drug was used only by injection, its administration was practiced in various ways: subcutaneously, intramuscularly, intravenously, and even into the spinal canal.

Subcutaneous injections

The most ineffective method of administering the drug is also quite painful and can lead to a lot of complications. This method is practically not used in treatment.

Intramuscular injections

More effective way injection treatment. The dosage for such administration of the drug is 0.5 g of Magnesia per kilogram of the patient’s weight.

Intravenous injections

One of the most effective methods of treatment with the drug. However, its use is fraught with fatal complications, so it is practically not used.

Intralumbar (injections into the spinal canal)

An effective method of treatment, however, it can also cause severe consequences for the patient.

Side effects

The drug Magnesia in any of its dosage forms has the ability to cause in the patient side effects during treatment, which can be expressed by the following symptoms:

Depression of cardiac activity;
State of bradycardia;
Decreased blood pressure;
The occurrence of arrhythmia;
The occurrence of flushes to the face;
Increased sweating;
CNS depression;
State of asthenia;
Headaches;
The emergence of an anxious state;
Confusion;
Decreased body temperature;
Attacks of nausea and vomiting;
State of polyuria;
Diarrhea;
Flatulence;
Feeling of intense thirst;
The occurrence of pain of a spastic nature.

Drug interactions

At simultaneous treatment Magnesia by injection with others medicines The following effects may be observed:

Peripheral muscle relaxants – the effect of these drugs is enhanced;
Nifedipine – may cause severe muscle weakness;
Anticoagulants, cardiac glycosides, phenothiazine - the effectiveness of these medications decreases;
Ciprofloxacin – the antibacterial ability of the drug increases;
Streptomycin – the antibacterial ability of the drug decreases;
Tetracycline antibiotics - their effect decreases and absorption from the gastrointestinal tract decreases.

When prescribing, you should also take into account the incompatibility of Magnesia with certain elements: calcium, barium, strontium, and also arsenic salts, carbonates, phosphates and bicarbonates of alkali metals, procaine hydrochlorides, tartrates, salicylates are not suitable for simultaneous administration. Can not use joint use with medications such as Clindamycin and Hydrocortisone.