Kvamatel instructions for use intravenously. Lyophilisate for solution preparation

Increased stomach acidity contributes to the development peptic ulcer. In patients with this disease, the feeling of hunger is accompanied by pain, nausea, and heartburn. With exacerbation of gastric ulcer and duodenum Doctors prescribe the drug Kvamatel. The medicine normalizes concentration of hydrochloric acid and promotes healing of damaged tissues.

Instructions for use Kvamatela

The drug is used to normalize stomach acidity. Doctors prescribe the medicine Kvamatel after gastroscopy and identification of ulcers. The drug blocks histamine H2 receptors, thereby reducing the production of peptin. Medicine to treat diseases gastrointestinal tract(Gastrointestinal tract) are taken as prescribed by a doctor. You cannot treat them on your own, because... blockers histamine receptors If taken uncontrolled, they can cause life-threatening side effects.

Composition and release form

The main active ingredient of the drug is famotidine, which blocks H2 receptors. The drug is available in the form of powder for injection and tablets. One package can contain 5 ampoules or 14/28 capsules. Together with the powder form of Kvamatel, a 0.9% sodium chloride solution is included in the package. It is used for injection instead of a solvent. Full composition different forms Kwamatela:

Release form	Components	Concentration in mg
Tablets 20 mg	Famotidine
	Colloidal silicon dioxide
	Magnesium stearate
	Povidone K90
	Sodium carboxymethyl starch (type A)
	Corn starch
	Lactose monohydrate

Ampoule 5 ml	Famotidine
Ampoule 5 ml	Aspartic acid, mannitol

pharmachologic effect

The drug acts on the walls of the stomach, blocking H2 receptors that promote the production of peptin and hydrochloric acid. The secretory function of the pancreas and blood circulation in the liver do not change. The effect of the H2 blocker appears 1 hour after administration, and the maximum concentration of the drug in the blood can be detected after 3 hours. Famotidine is excreted by the kidneys.

What is it prescribed for?

Doctors recommend taking the medicine to patients suffering from high stomach acidity. Kvamatel is effective for pancreatitis, erosive gastroduodenitis, ulcerative stomach disease, duodenal ulcers, gastric bleeding and other problems digestive system caused by acidic pH. Famotidine capsules help prevent exacerbation and relapse of the diseases listed above.

Directions for use and dosage

Before taking an H2 blocker, it is necessary to exclude malignancy of the ulcer. During treatment with the drug, the patient should avoid alcohol and other drinks that irritate the gastric mucosa. The tablet form of the drug is not chewed or crushed. Simultaneous use capsules with food increases the bioavailability of famotidine. The dosage of the H2 blocker is determined by the doctor for each patient separately based on the recommendations given in official instructions by application.

Kvamatel mini

This form of the drug is characterized by a reduced concentration of the active substance. It is prescribed when the patient suffers from heartburn. When taking 10 mg of the drug (1 tablet) therapeutic effect lasts for 9 hours. To get rid of an attack of heartburn for 10-12 hours, you should take 2 capsules (20 mg) of an H2 blocker. The drug is used until the symptoms of increased stomach acidity are completely eliminated, but not more than 14 days.

Tablets

For ulcers during an exacerbation, take 40 mg famotidine 1 time before bedtime or 20 mg 2 times a day. The doctor may increase the daily dose to 180 mg if necessary. For reflux esophagitis, take 1 capsule 2 times a day for 6 weeks. To prevent gastric and duodenal ulcers, take 20 mg of the drug before bedtime for 14 days.

In ampoules

The powder is diluted with a solution of sodium chloride, which is in the same package with the medicine. Kvamatel is prescribed intravenously if the patient has a negative reaction to taking the pills (nausea, vomiting, fever, etc.). This form of medication is intended for use in a hospital setting. You cannot give yourself injections with famotidine at home. Depending on the disease, the following dosages are prescribed:

20 mg every 6 hours if the patient has Zollinger-Ellison syndrome;
20 mg before general anesthesia to prevent suction gastric juice V Airways;
20 mg every 36-48 hours for impaired functions, elevated level creatinine in the blood.

The solution is prepared in the following way: powder from one ampoule is mixed with 5-10 ml of saline solution. The lyophilisate, after mixing with the solvent, retains a stable structure for 24 hours. At jet injection The duration of the procedure should be at least 2 minutes. The medicine is administered intravenously over 15-20 minutes. It is recommended to dilute the powder with sodium chloride and infusion solution right before the procedure.

special instructions

Treatment with Kvamatel is discontinued gradually. It is not recommended to suddenly stop taking pills, because this may trigger withdrawal symptoms. During the treatment period, the patient should exclude from the diet foods and drinks that irritate the gastric mucosa. Patients with functional disorders liver, the drug is prescribed in a reduced dosage. The use of medication may hide the symptoms of stomach cancer, so the presence of this disease should be ruled out before treatment.

Skin tests with an immediate reaction is carried out after completion of Kvamatel administration. This is due to the fact that it suppresses the activity of histamine H2 receptors. As a result, the reaction to the text carried out while taking the pills will be false. The drug has slight influence on the speed of psychomotor reactions, so patients should be very careful when taking capsules when controlling complex mechanisms and transport.

In childhood

Patients under 12 years of age are not given medicine. There are no indications for dose adjustment depending on the patient’s age in the official instructions for use. In medical practice, Kvamatel is used for the treatment of peptic ulcers in children from the age of 7 years. The child takes the medicine under the supervision of a doctor in a hospital, which reduces the likelihood of developing dangerous side effects to zero, because medical staff will be able to provide assistance quickly. Outside the hospital, the drug is rarely prescribed to children.

The medicine is part complex therapy. For every 1 kg of weight, the child should take 2 mg of famotidine. This formula is used to calculate the daily dose of the drug. The resulting figure is divided by 2, and then the medicine is given in the required concentration in the morning and evening. Maximum daily dose for children should not exceed 40 mg. If there is bleeding, the child is given intravenous injections. The daily dose is calculated in a similar way.

Kvamatel for animals

In veterinary practice medicine used to stop vomiting and prevent gastritis in pets. Cats and dogs are given a mini version of the medicine because... it contains only 10 mg of famotidine. For 1 kg of weight the animal is given 0.5 mg of the drug. The tablet is given once a day. In case of vomiting, the medicine is taken until the dog or cat’s condition returns to normal. The duration of treatment for gastritis is 14-28 days. If there are no signs of improvement, then you need to change the remedy. You can give medicine to an animal only as prescribed by a veterinarian.

Drug interactions

The drug changes the pH of the stomach to the alkaline side, so the absorption of Ketoconazole may slow down, because depends on the acidity level. After taking iron supplements and Amoxicillin, the patient should wait 2 hours and then take famotidine tablets. When taking the medicine simultaneously with drugs that inhibit bone marrow hematopoiesis, the number of granulocytes in the blood may decrease. Probenecid reduces the bioavailability of famotidine. The drug does not interact with drugs whose metabolism is associated with the cytochrome P450 system.

Side effects

Many patients complain of increased fatigue, mild visual disturbances. These side effects are common to all antihistamines. Often, after taking the pills, patients have problems with stool: diarrhea, constipation. If you are sensitive to the components of the drug, mild gastric bleeding may develop. During testing of the drug, patients rarely experienced the following side effects:

thrombocytopenia;
leukopenia;
headache;
dizziness;
violation heart rate;
increased body temperature;
muscle or joint pain;
loss of appetite;
dryness oral cavity;
gynecomastia.

Overdose

With hypersecretion of gastric juice, taking 800 mg of famotidine in patients does not cause severe side effects. Patients begin to feel sick, vomiting, tremors of the limbs, and motor agitation appear. Against the background of intoxication, pressure drops, collapse, ventricular arrhythmia, and tachycardia occur. Treatment is symptomatic; gastric lavage is mandatory. Possible use the following means:

Diazepam is administered to the patient against seizures;
ventricular arrhythmia is relieved by lidocaine;
in case of bradycardia, the condition is normalized with the help of Atropine;
Blood purification in case of impaired renal function is carried out by hemodialysis.

Contraindications

In case of hypersensitivity to any of the components of the composition, the medication is not prescribed. Patients with liver cirrhosis accompanied by portosystemic encephalopathy, liver or kidney failure should not be given the drug. It is acceptable to use famotidine to treat such patients, but at a dosage 2-3 times less than the standard one. Absolute contraindications to receive the funds are:

pregnancy;
age under 12 years;
lactation period.

Terms of sale and storage

According to the instructions, Kvamatel cannot be stored for longer than 5 years from the date of issue. Tablets and ampoules must be placed in a dry place, out of reach of children and direct sunlight. The air temperature in the room where the drug is located should not exceed 25 °C. Capsules cannot be stored outside the blisters, and ampoules must be in their original packaging until used. You can buy the product with a doctor's prescription.

Analogues

Gastrosidin, Gasterogen and Pepsidin have a composition similar to Kvamatel. They contain 20 mg of famotidine and come in powdered injection and tablet form. In terms of composition, another analogue of Kvamatel is Famosan. It contains famotidine in the same percentage, therefore it is used to treat gastrointestinal ailments caused by high concentrations of hydrochloric acid and relief stomach bleeding. The drug Kvamatel can be replaced with the following medications:

Zoran. Used for intolerance to famotidine. 1 tablet contains 150/300 mg of ranitidine. Suitable for treating children over 12 years of age.
Rantak. Second generation H2 blocker, contains ranitidine. The product is presented in the form of tablets and solution for intravenous administration.
Famotidine. Serbian drug, available in the form of tablets 20/40 mg. His average price at the pharmacy - 80 rubles.

Kwamatela price

In pharmacies you can buy Hungarian-made medicine. It is produced by Gedeon Richter. The production of packaging and instructions for use in Russian is carried out by the Moscow division of this pharmacological enterprise. The cost of the product depends on the concentration of the active substance and expiration date. Price of different forms of Kvamatel in large pharmacies in Moscow:

	Release form	Cost in rubles
Help window	20 mg, 28 capsules
	40 mg, 14 capsules
	20 mg, 5 ampoules
	20 mg, 28 capsules
	40 mg, 14 capsules
Laboratory of Beauty and Health	20 mg, 28 capsules
	40 mg, 14 capsules
	20 mg, 5 ampoules

The drug reduces the secretion of gastric juice, which is positive property for complex therapy of ulcers, heartburn and other diseases. It is used primarily for the treatment of adults; after consultation with a doctor, it can be prescribed to patients over 12 years of age. The course of treatment is usually long. After oral administration, it is quickly absorbed from the gastrointestinal tract. May cause side effects different organs and systems, however correct use and compliance with the dose, they rarely appear.

Dosage form

The composition is available in the form of film-coated tablets intended for oral administration.

Description and composition

The tablets are dark pink in color, biconvex in shape, and have an engraving on one side of the element. At the break, the tablet is white with minor inclusions.

Active ingredient medicinal composition acts – 40 mg.

To the list excipients include:

colloidal silicon dioxide;
magnesium stearate;
povidone;
sodium carboxymethyl starch A;
talc;
corn starch;
lactose monohydrate.

Part film shell The following connections are included:

red iron oxide;
colloidal silicon dioxide;
titanium dioxide;
macrogol;
sepifilm;
microcrystalline cellulose;
hypromellose.

Pharmacological group

– the active ingredient of the drug Kvamatel is a blocker of histamine type H2 receptors. Receptors are located in the mucous membranes of the stomach and upper intestines. Due to the activation of their influence, the process of producing hydrochloric acid is activated. An excess of this substance leads to damage to the mucous membranes of the gastrointestinal tract and disruption of digestive processes.

The peculiarity of the drug Quamtel is that it blocks the production of hydrochloric acid and ensures the normalization of the acidity of the stomach contents. The composition does not affect intestinal motility. The drug has no effect on the activity of the pancreas and the processes of hormone production. The effectiveness of the composition can be observed 1 hour after its use. The maximum effect occurs 3 hours after consuming the tablet. The effect lasts for 10-24 hours depending on individual characteristics the patient's body.

Indications for use

The list of indications for use of the product is presented as follows:

ulcerative lesions of the stomach and duodenum during exacerbation;
treatment and prevention of development ulcerative lesions Gastrointestinal tract;
gastroduodenitis of erosive type;
dyspepsia, with increased secretory function;
reflux esophagitis;
prevention of recurrent bleeding;
prevention of aspiration of gastric juice during the administration of general anesthesia.

for adults

Drug with increased caution prescribed to patients with impaired liver and kidney function. The drug is used to treat patients old age under conditions of strict adherence to the dosage regimen.

for children

The use of the composition is not recommended for children under 18 years of age; however, cases of use of the composition in pediatric practice described by doctors. The composition is often prescribed in reduced dosages to children over 7 years of age.

Use of the product during pregnancy is prohibited. If it is necessary to use the composition during breastfeeding, the woman must decide whether to transfer the child to feeding with artificial breast milk substitutes.

Contraindications

The list of contraindications to the use of the product is presented as follows:

pregnancy period;
childhood;
hypersensitivity to the components of the drug composition.

Applications and dosages

Quamtel tablets are intended for oral administration. It is recommended to take the drug in regulated dosages immediately before meals with a tablet. sufficient quantity liquids.

for adults

For the treatment of ulcerative lesions during exacerbation, Quamtel is prescribed 2 tablets 1 time per day. The duration of the course of treatment may vary depending on clinical picture accompanying the disease. If the therapeutic effect when using Quamtel at the indicated dose is not observed, it is adjusted with an increase.

To prevent recurrence of stomach ulcers, the drug is taken in the amount of 1 tablet daily. The course of admission is 1 month.

For reflux esophagitis, the drug is taken 1 tablet 2 times a day for 1.5 months.

for children

The dosage for children is determined individually at the rate of 2 mg of the drug per 1 kg of the patient’s body weight. The daily dose is taken in two doses, maintaining equal time intervals between consumption. The maximum daily dose for children under 14 years of age should not exceed 40 mg.

for pregnant women and during lactation

Kvamtel is not used during pregnancy and breastfeeding.

Side effects

Adverse reactions may occur during the use of the drug.

Digestive dysfunctions:

dry mouth;
nausea and;
flatulence;
hepatitis;
diarrhea;
loss of appetite;
acute pancreatitis;
impaired activity of liver transaminases.

From the side of hematopoiesis:

hypoplasia bone marrow;
bone marrow aplasia;
agranulocytosis;
pancytopenia;
leukopenia.

Allergic reactions:

skin rash accompanied by itching;
bronchospasm;
Quincke's edema;
anaphylactic shock;

Disorders of the cardiovascular system:

arrhythmia;
bradycardia.

Nervous system:

headache;
dizziness;
drowsiness;
increased fatigue;
hallucinations;
confusion.

Sexual disorders:

among women;
decreased sex drive;
hymenocastia.

Dermatological disorders:

alopecia;
acne vulgaris;
excessive dry skin.

It is extremely rare that body temperature rises while taking Kvametal.

Interaction with other drugs

Against the background of a decrease in acidity, the absorption of ketoconazole and. Antacids significantly reduce the effectiveness of Quamtel, so the recommended interval between taking them should be observed.

With the simultaneous use of compounds that inhibit bone marrow hematopoiesis, the risk of developing neutropenia increases. The active substance enhances the absorption of clavulanic acid.

special instructions

The active component has the ability to mask the course of gastric cancer in a patient, so its use is possible after excluding the fact of the development of malignant tumors.

At abrupt refusal Withdrawal syndrome appears from the use of the drug, the patient’s condition rapidly deteriorates. The dosage of the composition should be reduced gradually.

In case of disturbances in the liver, the dose of the drug composition should be reduced systematically; in patients with liver failure or cirrhosis, the composition is prescribed with increased caution.

During the period of use of the drug Quamtel, you should follow a diet that includes complete failure from taking foods that irritate the mucous membranes of the stomach.

During the period of application of the composition, you should avoid work that requires high concentration attention. It is worth getting rid of driving vehicles.

Overdose

Overdose symptoms:

severe tremor of the limbs;
increased physical activity;
excessive excitability;
decreased blood pressure;
tachycardia;
collapse;
manifestation of nausea and.

To eliminate the described consequences, gastric lavage should be performed and the patient should be given enterosorbent. In some cases, hospitalization is indicated and symptomatic therapy. Hemodialysis is possible.

Storage conditions

The medicine is sold to the population through a network of pharmacies. Required condition dispensing of a medicinal composition is determined by the presence of a prescription from the patient. The drug should be stored in optimal conditions at a temperature environment no higher than 25 degrees. Keep away from children. Do not use after expiration date.

Analogues

Kvamatel can be replaced with the following analogues:

Famosan is a Czech drug produced in tablets containing 20 mg or 40 mg of famotadine. The medicine has similar indications and contraindications to Kvamatel and causes similar unwanted reactions. It differs from it only in the formative substances, which must be taken into account if the composition of the drug is intolerant.
Zantac is a substitute for Quamatel in the therapeutic group. His active ingredient is . The drug is available in effervescent and regular tablets. It can be used as an antiulcer agent in patients over 12 years of age.
belongs to Kvamatel substitutes in the clinical and pharmacological group. The medicine is produced in capsules and is recommended as antiulcer drug in adult patients.
refers to antiulcer medications containing pantoprozole as a medicinal component. The drug is commercially available in tablets and lyophilisate, from which it is prepared injection solution for injection into a vein. This allows it to be used when for some reason it is impossible to take the medication orally. The medicine is prohibited from being prescribed to children, pregnant women and breastfeeding women.

Price

The cost of Kvamatela is on average 173 rubles. Prices range from 66 to 453 rubles.

The anti-ulcer drug Kvamatel is a histamine H2 receptor blocker.

The drug is produced in the form of tablets and lyophilisate, which is placed in glass bottles. It comes with a solvent in ampoules for intravenous administration.

The drug Kvamatel in the form of tablets is produced in two types, distinguished by the concentration of the active substance famotidine.

Those tablets that contain 20 milligrams of the active substance have a convex shape and are marked F20 on one side. Each tablet is coated with a pink coating.

Those tablets that contain 40 milligrams of the active substance have a convex shape and are marked F40 on one side. Each tablet is coated with a dark pink film.

The lyophilisate is white in color and is used to prepare a solution for intravenous administration. It comes with a clear, colorless and odorless solvent. Each bottle contains 72.8 milligrams of lyophilisate.

Action of Kvamatel

Pharmacology

Due to the fact that the drug blocks histamine receptors, it reduces the level of pepsin and the ability to form hydrochloric acid, thereby increasing the acid-base balance level for gastric juice. The drug is not capable of influencing gastric fluctuations (natural), as well as the activity of the pancreas (exocrine) and blood circulation in the venous system(portal).

60 minutes after the drug has been taken, its active effect begins.

Kvamatel is excreted in the urine.

Pharmacokinetics

The pharmacokinetics of the drug is linear in nature.

Suction

Complete absorption of the drug from the gastrointestinal tract does not occur. The main effect can be achieved after three hours. Bioavailability ranges from 40 to 45 percent, which can increase with simultaneous food intake and decrease when taking antacids and Kvamatel at the same time.

Distribution

The drug has a 20% binding ability to plasma protein. It is also capable of penetrating the placental barrier. May stand out in breast milk.

Metabolism

Metabolization of the drug occurs in the liver by 35%, during which S-oxide is formed.

Removal

· The drug has a half-life of approximately three hours. The main part of the active substance Kvamatel is excreted unchanged from the body in the urine.

Kvamatel indications

The use of the drug Kvamatel is indicated for the following ailments:

For peptic ulcers of the duodenum and stomach in acute phases, to prevent their relapses;
In the treatment and prevention of symptomatic ulcers of the duodenum and stomach;
With erosive gastroduodenitis;
For functional dyspepsia associated with increased function gastric secretions;
With reflux esophagitis;
With Zollinger-Ellison syndrome;
To prevent bleeding from upper sections Gastrointestinal tract and their relapses;
To prevent aspiration of gastric juice during general anesthesia (Mendelssohn syndrome).

Kvamatel contraindications

The drug has practically no contraindications, with the exception of certain categories of patients who should not take the drug due to their current situation:

During pregnancy;
During breastfeeding;
In childhood;
In case of hypersensitivity to famotidine and other components of the drug.

Kvamatel should be prescribed with caution if:

renal failure and liver;
liver cirrhosis;
cross-type allergic reactions;

Kvamatel instructions for use

Instructions for use of the drug contain detailed guide on the methods of using Kvamatel for treatment and determining the dosage.

Kvamatel dosage

In tablet form

for the treatment of stomach and duodenal ulcers in acute phases, the recommended dose of Kvamatel is 40 milligrams of the drug at night or 20 milligrams twice a day. As necessary, you can increase the daily dose of Kvamatel from 2 to 4 times. The course of treatment is from one to two months;
to prevent exacerbation of stomach and duodenal ulcers, the recommended dose of Kvamatel is 20 milligrams of the drug at night;
for the treatment of inflammation of the esophagus, which is caused by in reverse stomach contents, the recommended dose of Kvamatel is 20 milligrams twice a day for 45 days. As necessary, the dose of Kvamatel can be doubled;
for Zollinger-Ellison syndrome, the recommended initial dose of Kvamatel is 20-40 milligrams of Kvamatel periodically (6 hours). The dosage can be varied depending on the condition of the patient. The duration of treatment is determined by the attending physician;
to prevent gastric juice from entering the respiratory tract during general anesthesia The recommended dose of Kvamatel is 40 mg the day before surgery.

Kvamatel intravenously

Intravenous administration of the drug is indicated only when the patient is unable to take it orally. Kvamatel is administered exclusively intravenously by stream or drip.

for Zollinger-Ellison syndrome, the recommended dose of Kvamatel is 20 milligrams of Kvamatel periodically (6 hours). Subsequently, the dosage can be adjusted depending on the condition of the patient;
in order to prevent the penetration of gastric juice into the respiratory tract during general anesthesia, 20 milligrams of the drug intravenously the day before surgery.

Kvamatel during pregnancy

The use of the drug during pregnancy is prohibited at any stage.

Side effects

Side effects of taking the drug can be observed in disorders of normal activity various systems body.

Interactions with other tools

The simultaneous use of Kvamatel with other drugs leads to either a decrease or an increase in their absorption, which directly depends on their pharmacological type.

Kvamatel analogues

On pharmacy shelves, in addition to the drug itself, you can also find quite a few of its analogues. For example:

The drug Gistak in tablets;
The drug Zantac in the form effervescent tablets, as well as solution for injection;
The drug Ranisan in tablet form;

Kvamatel price

The price range of the drug Kvamatel is quite large. Its cost ranges from 60 to 443 rubles. However, the price of a drug in this range depends on the form of release, the concentration of the active substance and the number of copies in the package.

The drug Kvamatel is a medication from the group of histamine receptor blockers and antiulcer drugs. His active ingredient famotidine stops increased secretion of gastric juice, prevents the development of erosions and ulcers in the stomach. Read the instructions for use of the medicine.

Composition and release form

Quamatel is presented in mini- and regular tablets, lyophilisate. Their composition and packaging:

	Mini tablets	Pills	Lyophilisate
Description	Light pink round tablets	Pink pills	White powder, solvent – transparent colorless
Famotidine concentration, mg		20 or 40 per 1 piece.	20 per 1 bottle
Auxiliary components	Hypromellose, colloidal silica, microcrystalline cellulose, magnesium stearate, sepifilm (macrogol stearate), povidone, macrogol, sodium carboxymethyl starch, titanium dioxide, talc, red iron oxide, corn starch, lactose monohydrate		Mannitol, aspartic acid. Solvent – water, sodium chloride.
Package	Blisters of 14 pcs., 1 or 2 blisters in a pack with instructions for use		Vials of 72.8 mg – 5 pcs. complete with 5 ampoules of solvent

Pharmacological properties

The histamine receptor blocker Kvamatel inhibits the production of hydrochloric acid, basal and that caused by stimulation of acetylcholine, gastrin and histamine receptors. While taking the medicine, pepsin activity decreases and pH (acidity) increases. Famotidine has a slight effect on liver enzymes; it begins to work an hour after oral administration and half an hour after administration. parenteral administration. The maximum effect of the drug develops after three hours and lasts for 12–24 hours.

The medication has incomplete absorption, 40% bioavailability, which increases with food intake and decreases with the use of antacids. The active component binds to plasma proteins by 15%, penetrates meninges and through the placenta, found in breast milk. A third of the dose of Kvamatel is metabolized in the liver to form indomethacin. The half-life is three hours, the residues are excreted by the kidneys.

Indications for use

The instructions for use of the histamine blocker Kvamatel indicate the indications for use. This:

Zollinger-Ellison syndrome;
reflux esophagitis;
gastroesophageal disease;
exacerbation of peptic ulcer of the esophagus, stomach or duodenum, prevention of its relapse against the background of increased acidity;
treatment and prevention of symptomatic gastrointestinal ulcers;
prevention of recurrent bleeding digestive tract;
erosive gastroduodenitis;
Mendelssohn's syndrome (aspiration of gastric juice during general anesthesia).

How to take Kvamatel

Instructions for use of Kvamatel differ depending on the form of release of the medication. The tablets are taken orally, the solution is taken parenterally. Both types can be used in the treatment of acute pancreatitis (as part of complex therapy). Severe forms diseases are treated intravenous injections or Kvamatel infusions. For elimination mild degree illness (in the absence of vomiting, nausea), tablets are used.

The dosage for children is calculated as 2 mg per kg of body weight, but not more than 40 mg per day (the dose is divided into two equal doses with an interval of 12 hours). Adult dosage is 20–60 mg twice a day. Intravenous administration of the drug eliminates pain in two days and normalizes alpha-amylase activity in 5–7 days. The tablets eliminate pain on the third day, and enzyme activity on the 3rd–5th days of therapy. After 3-4 days of treatment, digestive disorders are relieved.

According to the instructions, treatment of acute pancreatitis with Kvamatel lasts no longer than two weeks. During this time, the pancreas manages to restore normal sizes. After 14 days, the dose is reduced by half, taken for another week, after which treatment is discontinued. This week is the time to cancel therapy so that there is no “rollback” to the previous state and deterioration of well-being.

According to the instructions, the tablets are prescribed for oral administration. For peptic ulcers, take 40 mg once a day before bedtime or 20 mg twice a day. In severe cases, the dose is increased to 80–160 mg. Treatment lasts 4–8 weeks. Other purposes:

To prevent exacerbations of ulcers, take 20 mg once a day before bedtime.
For reflux esophagitis, 20–40 mg of the drug is indicated twice a day.
For Zollinger-Ellisorn syndrome, 20–40 mg is prescribed every 6 hours, then the dose can be increased to 240–480 mg per day.
To prevent aspiration of gastric juice, 40 mg tablets are prescribed the day before or on the morning of the operation.
If creatinine clearance is reduced and renal failure is observed, then the dosage of Kvamatel is reduced to 20 mg, or the interval between doses is increased to 36–48 hours.

Kvamatel mini

Mini-Kvamatel tablets are taken for symptoms of heartburn or signs of dyspepsia. They are taken one at a time, swallowed whole, washed down with a small amount of water. You should not take more than two tablets per day. If the symptoms of the disease do not go away within two weeks of regular use of the drug, you should visit a doctor.

Lyophilisate for solution preparation

Kvamatel in the form of a diluted lyophilisate is used intravenously in a stream or drip; the indication is that it is impossible to take the drug orally. The solution is used only in hospital settings, average dose equal to 20 mg twice a day (every 12 hours), the maximum single dose is 20 mg. For Zollinger-Ellison syndrome, the dose is administered every 6 hours. To prevent aspiration of gastric contents during general anesthesia, 20 mg of the drug is administered two hours before surgery.

If your kidney function is impaired or reduced level serum creatinine, the daily dose of the drug is reduced to 20 mg, or the interval between administrations is increased (up to 36–48 hours). If liver function is impaired, the drug is prescribed with caution. To obtain a solution, the contents of the ampoule are diluted with 5–10 ml of saline solution (ampule with solvent). The resulting liquid retains its properties for 24 hours at room temperature. The drug is administered for at least two minutes, the infusion lasts 15–30 minutes. The solution is prepared before the procedure.

special instructions

The instructions for use of Kvamatel contain the paragraph special instructions. Some excerpts from it:

Taking famotidine may reduce the symptoms of stomach cancer; before starting treatment, the possibility of malignant neoplasm.
Long-term treatment weakened or stressed patients can lead to bacterial lesions stomach and further spread of infection.
The drug inhibits the acid-stimulating effect of histamines and pentagastrin, so it should be discontinued a day before testing for the determination of these substances.
During therapy, you should avoid taking foods, drinks and medications that irritate the mucous membrane of the digestive tract.
During treatment, care should be taken when driving vehicles and operating dangerous machinery.

Kvamatel for cats

The drug can be used in veterinary prophylaxis. Indications are the treatment and prevention of gastritis in cats. Veterinarians use Kvamatel in mini-tablets at a dosage of 0.5 mg per kg of body weight. For a cat weighing 4-5 kg, the tablet is divided into 4 parts, a quarter is given once a day in the evening, for a course of 2-4 weeks. If the animal’s vomiting does not go away after taking the medication, therapy is canceled.

Kvamatel for dogs

Similarly, Kvamatel mini-tablets for dogs are used in veterinary medicine. According to the instructions, the dosage for an animal is 0.5 mg per kg of body weight. The medication is given to dogs and puppies in the evening before bed, the course lasts until the main symptoms of gastritis (nausea, vomiting) are eliminated. If signs of the disease do not go away within two weeks, you should contact your veterinarian.

In childhood

According to the instructions for use, the drug is contraindicated for use by children under 16 years of age, but in practice, doctors prescribe tablets and solution to patients over seven years of age. Taking the drug helps reduce high acidity of gastric juice. Compared to similar medications Nizatidine and Roxatidine, it works better and is cheaper. In its action, Kvamatel is similar to inhibitors proton pump(Omez), but is allowed for children under 12 years of age. The use of the drug enhances the restoration of the epithelium, neutralizes free radicals.

Kvamatel during pregnancy

The use of Kvamatel during pregnancy and breastfeeding is strictly prohibited. According to the instructions, the active component famotidine penetrates the placental barrier and can therefore negatively affect the development of the fetus. When breastfeeding, the active substance is found in breast milk, so during lactation you should avoid taking pills or giving injections.

Drug interactions

The instructions for use of Kvamatel refer to its drug interactions with other drugs. Possible combinations and effects:

Kvamatel is taken two hours after taking Aspirin, Ketoconazole or Itraconazole, because it interferes with their absorption when the pH of the stomach contents increases.
Simultaneous use of the drug with antacids and Sucralfate leads to a slower absorption of famotidine, so you need to maintain an interval of 1-2 hours between them.
Combining the drug with drugs that inhibit bone marrow hematopoiesis leads to an increased risk of developing neutropenia.
Famotidine increases the degree of absorption of clavulanic acid and Amoxicillin.
Combination with Lidocaine, Nimesulide is prohibited.
You can dissolve the lyophilisate with a 5% dextrose solution.

Side effects and overdose

Symptoms of a drug overdose are decreased blood pressure, vomiting, collapse, motor agitation, tachycardia, and tremor. Treatment consists of gastric lavage, hemodialysis, and administration of atropine. According to the instructions, side effects Kwamatela are:

acute pancreatitis, loss of appetite, abdominal pain, constipation, flatulence, diarrhea, bloating, belching;
thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, anemia, bone marrow aplasia or hypoplasia, increased levels of granulocytes, neutrophils, eosinophils, erythrocytes and leukocytes;
allergies, anaphylactic shock, urticaria, angioedema, skin rash, bronchospasm, itching, dermatitis, erythema;
decreased blood pressure, arrhythmia, rapid heartbeat;
confusion, headache, hallucinations;
gynecomastia (increased production of the hormone prolactin), amenorrhea (absence of menstruation), decreased libido;
hepatitis;
limb spasms;
muscle spasms, arthralgia;
dry skin, alopecia, acne;
fever.

Contraindications

The drug is prescribed with caution for renal, liver failure, liver cirrhosis due to a history of portosystemic encephalopathy (previously). The instructions indicate contraindications for the use of injections and tablets:

pregnancy, lactation;
childhood;
increased sensitivity to the components of the drug and histamine receptor blockers.

Terms of sale and storage

Kvamatel is prescription drug. Tablets are stored at temperatures up to 30 degrees for five years, lyophilisate - at a temperature of 15-25 degrees for three years (the solvent can be stored for five years).

Analogues

You can replace the drug with products from the same group and a similar or different composition. Drug analogues include:

Gistak – tablets based on ranitidine;
Zoran is an antiulcer tablet drug containing ranitidine;
Ranitidine is a histamine receptor blocker tablet based on the component of the same name;
Ulcodine - tablets containing ranitidine;
Cimetidine – antihistamine against ulcers based on the active substance of the same name;
Acyloc - antiulcer injection solution and tablets containing ranitidine;
Omez is an analogue of Kvamatel in the format of capsules and lyophilisate for a solution based on omeprazole and domperidone, which has an antisecretory effect.

Kwamatela price

You can buy the medicine via the Internet or regular pharmacies at prices that are affected by the form of release of the drug, the level of famotidine content, and the trade markup. approximate cost in Moscow.

Kvamatel in ampoules is used as an antiulcer agent. It is designed to block histamine H2 receptors. Each ampoule contains lyophilized powder for preparing the injection; it is sold with a solvent and instructions for use. The price of the drug is affordable for patients.

Instructions for use of the drug in ampoules

If it is impossible to take the drug orally, it is used intravenously or through a dropper; reviews indicate rapid absorption main components body. Kvamatel ampoules, the indications for use of which will be an excellent guide, can be used only in a hospital setting, as soon as it becomes possible to use the drug orally, they switch to tablets. Every twelve hours, the dosage should be no more than 20 mg.

More frequent use is acceptable for Zollinger-Ellison syndrome, when it is necessary to use Kvamatel every 6 hours. During the process, the attending physician adjusts the dose, taking into account clinical condition patient and the amount of hydrochloric acid in the stomach. The price of the drug allows you to carry out without problems full course treatment.

On the eve of the operation, 20 mg of the drug is administered intravenously under general anesthesia to prevent aspiration of contents in the stomach. The time before surgical intervention should not be less than two hours, according to reviews from doctors. If a patient is diagnosed with renal dysfunction or an increase in serum creatine levels in the blood of more than 3 mg/dL, the daily dose of the drug is reduced and the interval between its doses necessarily increases from 36 to 48 hours. The drug should be prescribed with caution to people with liver dysfunction; doses are regulated by a doctor, but always reduced.

Requirements for preparing the solution

The contents of the ampoule for use, before intravenous administration, are pre-diluted saline solution in an amount of 5-10 ml, as indicated in the instructions. The prepared solution can be used within 24 hours after preparation if it has been stored at room temperature. Enter ready solution costs at least two minutes, in accordance with the instructions, if a dropper is used, the infusion duration is from 15 to 30 minutes.

If the solution was prepared:

It is recommended by reviews and doctors to prepare a solution for intravenous use immediately before it is applied. The price of the medicine is not so high that the patient uses an expired solution; it is important to comply with these deadlines.

At Kwamatela wide range of indications for use and affordable price, This excellent remedy for the prevention and treatment of peptic ulcer of the duodenum and stomach, symptomatic phenomena against the background stressful situation, taking non-steroidal anti-inflammatory drugs, about which there is a lot positive feedback. It is used according to the instructions before surgery and for patients with identified functional dyspepsia against the background of increased secretory function of the stomach.

The drug is often prescribed for use in erosive gastroduodenitis, reflux esophagitis, and Zollinger-Ellison syndrome. Administration of the drug helps prevent bleeding from the upper gastrointestinal tract.

Despite big list side effects in the instructions, in practice, Kvamatel is perfect for patients and has a low price, as evidenced by numerous reviews. It is affordable and wide range actions, the minimum age of patients is three years. Experts in the field of gastroentorology note high efficiency active substances in the composition of the drug. This great option for those who have severe allergies to the group medicines related to .

Kvamatel reviews describe how quickly and during what short course of treatment it relieves sharp pain and symptoms. The drug is simply irreplaceable for people with stomach ulcers and duodenal problems.

Kvamatel, despite great amount side effects, quite well tolerated by the body. I felt improvement soon after starting treatment.

Vladimir

After taking it, I experienced a slight headache, but the drug coped well with the main problem and is inexpensive.

Analogues of Kvamatela

Kvamatel analogues are drugs similar to it By active substance as part of. Among the analogues one can single out quite a few wide list drugs of different price categories: Gasterogen; Gastrosidin; Kvamatel mini; Pepsidin; Ulfamid; Phamopsin; Famosan; Famotel; Famotidine. The price of Kvamatel ampoules 20 mg varies from 397 rubles.

Use of the drug for childhood diseases

The use of the drug according to the instructions in a child should be carried out only after consultation with a doctor and appropriate examination. Kvamatel acts quickly and always very effectively eliminates problems in the gastrointestinal tract, this can be seen from reviews on the Internet.

The minimum age of the child is three years old; it is strictly forbidden to use the medicine if hypersensitivity to the substances in the composition is detected; the cost of non-compliance with the requirements may be the occurrence of anaphylactic shock in the patient. Special attention With young patients, it is worth paying attention to the child’s susceptibility to other drugs that act as histamine H2 blockers.

When is the best time to use Kvamatel intravenously?

There are many reasons when taking pills is impossible, then the drug is prescribed intravenously in a hospital setting. Among them are:

Erosive and ulcerative lesions;
Bleeding in the gastroduodenal zone;
The presence of intense pain syndrome with gastric and duodenal ulcers;
In the presence of reflux esophagitis, when oral administration is complicated by problems with the esophagus;
With regular vomiting, presence of fistulas or coma;
During general anesthesia;
In the treatment of acute stress ulcers due to frostbite or burns.

As shown medical practice and reviews such use of Kvamatel intravenously is 87% effective. The administration is characterized by a more rapid inhibition of gastric secretion, which cannot be said about the tablet drug. Maximum effect from use can be achieved within half an hour after its administration. By taking tablets it is achieved in no less than an hour.

Using the drug according to the instructions helps in an acute situation to eliminate surgery. It is recommended to administer Kvamatel 20 mg twice every 24 hours at equal intervals of 12 hours. If a peptic ulcer is detected in a patient, this form of its use allows doctors to stop pain syndrome already within two days. It has proven effective in patients with acute and chronic pancreatitis.

In Kvamatel’s photo you can see transparent ampoules with lyophilisate for injection. Powder white or almost white, each ampoule comes with a solvent for preparing intravenous solution, which has no color and characteristic odor. Each solution is in a separate ampoule and is completely sterile.

Kvamatel does not have an extensive composition; it contains famotidine - active substance in the amount of 20 mg per ampoule. Mannitol and aspartic acid are used as excipients. The solution for preparing the injection is a solution made from the substance of the same name and water. for injections. In pharmacies you can find the drug in doses of 20 and 40 mg. The effect of the drug lasts for 10-12 hours and is aimed at suppressing nocturnal and basal secretion.

Possible side effects

Available with the drug list of possible side effects, despite the large area of action, including a feeling of dry mouth, constipation or diarrhea, lack of appetite, vomiting. In some cases, taking Kvamatel may be accompanied by skin itching and the appearance of urticaria, abdominal pain, acute pancreatitis. Other side effects include agranulocytosis, bronchospasm, leukopenia and pancytopenia, thrombocytopenia. In patients with intolerance to the drug and its main components and others, anaphylactic shock, angioedema, bradycardia or arrhythmia rarely occur.

Often taking the drug was accompanied by headache, confusion and hallucinations; a person may feel dizzy and drowsy with tinnitus and loss of visual acuity. The following may also appear:

Decreased libido;
The appearance of fever;
Acne;
Dry skin.

TO side effects additionally include gynecomastia, myalgia, hyperprolactinemia, alopecia and arthralgia.

Taking the drug is contraindicated for women during lactation and pregnancy, as well as for children under three years of age. If the drug is prescribed during lactation, breast-feeding stop.

The study did not reveal any severe complications in case of an overdose of the drug, but patients are required to comply with the dosage and take it in a hospital setting. The main treatment for overdose is a simple gastric lavage and further therapy.

Sharing the drug with Ketoconazole reduces absorption, the reason for this is a change in the pH of the juice in the stomach. Also, a decrease in absorption can be observed with joint reception Kvamatela with antacid drugs.