Reviews for famotidine. Antiulcer drug Famotidine - instructions for use

Pharmacodynamics

III generation H2-histamine receptor blocker. Suppresses basal and histamine, gastrin and acetylcholine-stimulated production of hydrochloric acid.

Reduces pepsin activity. Strengthens the protective mechanisms of the gastric mucosa and promotes the healing of damage associated with the effects of hydrochloric acid (including the cessation of gastrointestinal bleeding and scarring of stress ulcers) by increasing the formation of gastric mucus, the content of glycoproteins in it, stimulating the secretion of bicarbonate by the gastric mucosa, endogenous synthesis of prostaglandins in it and the rate of regeneration. Does not significantly change the concentration of gastrin in plasma. Weakly inhibits the cytochrome P450 oxidase system in the liver. After oral administration, the effect begins within 1 hour and reaches a maximum within 3 hours. The duration of action of the drug after a single dose depends on the dose and ranges from 12 to 24 hours.

Pharmacokinetics

After oral administration, it is quickly absorbed from the gastrointestinal tract. After oral administration, the time to reach maximum plasma concentration (TCmax) is 1-3.5 hours.

Bioavailability is 40-45%, increases when taken with food and decreases when taking antacids. Communication with plasma proteins is 15-20%. 30-35% of famotidine is metabolized in the liver (to form S-oxide). Elimination mainly occurs through the kidneys: 27-40% of the drug is excreted unchanged in the urine.

The half-life is 2.5-4 hours, in patients with creatinine clearance below 30 ml/min it increases to 10-12 hours. In patients with severe renal failure (creatinine clearance below 10 ml/min) it increases to 20 hours. Penetrates the placental barrier and is excreted in breast milk.

2. indications for use

Famotidine should be taken when you have a peptic ulcer of the duodenum and stomach in the acute phase, to prevent relapses.
Treatment and prevention of symptomatic ulcers of the stomach and duodenum (associated with the use of non-steroidal anti-inflammatory drugs, stress, postoperative ulcers).
Famotidine should be taken when you have erosive gastroduodenitis.
Functional dyspepsia associated with increased secretory function of the stomach.
Reflux esophagitis.
Zollinger-Ellison syndrome.
Prevention of recurrent bleeding from the upper gastrointestinal tract.
Prevention of aspiration of gastric juice during general anesthesia (Mendelssohn syndrome).

3. Method of application

Inside. For gastric and duodenal ulcers in the acute phase, symptomatic ulcers, erosive gastroduodenitis, Famotidine is usually prescribed 20 mg 2 times a day or 40 mg 1 time a day at night. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks. For dyspepsia associated with increased secretory function of the stomach, 20 mg is prescribed 1-2 times a day.

To prevent recurrence of peptic ulcer, 20 mg is prescribed once a day before bedtime.

For reflux esophagitis - 20-40 mg twice a day for 6-12 weeks.

For Zollinger-Ellison syndrome, the dose of the drug and the duration of treatment are determined individually. The starting dose is usually 20 mg every 6 hours and can be increased to 160 mg every 6 hours.

To prevent aspiration of gastric juice during general anesthesia, 40 mg is prescribed in the evening and/or morning before surgery. Famotidine tablets should be swallowed without chewing, with plenty of water.

In case of renal failure, if creatinine clearance is less than 30 ml/min or serum creatinine is more than 3 mg/100 ml, the daily dose of the drug should be reduced to 20 mg.

4. Side effects

From the digestive system: dry mouth, nausea, vomiting, abdominal pain, constipation, diarrhea, loss of appetite, increased activity of liver transaminases, cholestatic jaundice, acute pancreatitis.
From the nervous system: headache, dizziness, asthenia, drowsiness, insomnia, fatigue, depression, agitation, ringing in the ears, hallucinations, confusion, blurred vision.
From the cardiovascular system: decreased blood pressure, bradycardia, atrioventricular block, arrhythmia, vasculitis.
Allergic reactions: skin rash, itching, urticaria, bronchospasm, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic shock.
From the hematopoietic organs: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.
From the reproductive system: with long-term use of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, decreased potency.
Others: acne, alopecia, fever, arthralgia, myalgia.

5. Contraindications

Pregnancy, lactation, liver failure, childhood, hypersensitivity to the components of the drug. Lactose intolerance, lactase deficiency or glucose-galactase malabsorption.

6. During pregnancy and lactation

During pregnancy and lactation, use of Famotidine contraindicated.

7. Interaction with other drugs

Due to the increase in gastric pH, coadministration may decrease absorption.

When used simultaneously with antacids or sucralfate, the absorption rate of famotidine decreases, so the break between taking these drugs should be at least 1-2 hours.

Increases the absorption of amoxicillin and clavulanic acid.

Bone marrow depressants increase the risk of developing neutropenia.

8. Overdose

Symptoms:

Possible worsening side effects.

Treatment:

gastric lavage, symptomatic therapy, hemodialysis.

9. Release form

Film-coated tablets, 20 mg and 40 mg - 10, 20 or 30 pcs.

10. Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 ° C.
Keep out of the reach of children.

Best before date

3 years.

11. Composition

1 tablet 20 mg Famotidine contains:

famotidine 20 mg;
Excipients(core): magnesium stearate - 1.90 mg; potato starch - 16.82 mg, povidone (polyvinylpyrrolidone) - 6.36 mg, microcrystalline cellulose - 53.92 mg, lactose monohydrate (milk sugar) - 100.00 mg.

1 tablet 40 mg contains:

famotidine - 40 mg;
Excipients(core): magnesium stearate - 2.10 mg; potato starch - 16.00 mg, povidone (polyvinylpyrrolidone) - 7.00 mg, microcrystalline cellulose - 53.90 mg, lactose monohydrate (milk sugar) - 100.00 mg.

12. Conditions for dispensing from pharmacies

The drug is dispensed according to the prescription of the attending physician.

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* Instructions for medical use of the drug Famotidine are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

Treatment of diseases of the digestive tract can be carried out using a variety of medications. In order for therapy to be as effective as possible, it must be selected by a doctor, focusing on the individual characteristics of the patient, the type of disease and its course. After all, different drugs can affect different patients in completely different ways. Thus, sometimes histamine receptor blockers can be used in the treatment of ulcerative lesions of the digestive tract. The drug we are currently considering is one of them. What are Famotidine tablets, what do their instructions for use tell the patient taking them? Naturally, we’ll tell you what the pills help with.

What is Famotidine??

So, Famotidine is a tablet that is based on the component of the same name “famotidine”. It is a blocker of H2 type histamine receptors. But what does it mean?

H2 type receptors are located inside the mucous membranes of the stomach, as well as the mucous membranes of the upper intestines. Activation of this type of receptor causes more active synthesis of hydrochloric acid. It should be noted that their activation occurs under the influence of a number of factors, including due to the conduction of a nerve impulse along the vagus nerve, which occurs when the stomach is full. In other words, even when drinking a glass of water, histamine H2 receptors are activated, leading to active synthesis of hydrochloric acid. And an excess amount of hydrochloric acid causes digestive disorders and damage to the mucous membranes of the digestive tract.

Famotidine blocks the activity of H2-histamine receptors, which reduces the production of hydrochloric acid and, accordingly, reduces the level of acidity of gastric juice. In addition, blocking n2 receptors leads to a slight decrease in the activity of pepsin (an enzyme in gastric juice).

The use of Famotidine can only cope with the problem of excess gastric acidity. This medicine does not at all affect the motility of the gastrointestinal tract, due to which the evacuation of stomach contents into the duodenum occurs in a timely manner. In addition, Famotidine does not affect the activity of the pancreas or the production of enzymes and hormones. Also, the medicine is unable to affect the activity of liver enzymes.

What does Famotidine help with??

This medication can be used for the treatment and prevention of a number of pathological conditions. It is used for:

Exacerbations of ulcerative lesions of the stomach or duodenum;
- the need to avoid relapses of ulcerative lesions of the stomach or duodenum;
- therapy and prevention of symptomatic ulcerative lesions of these organs, for example, due to the consumption of non-steroidal anti-inflammatory drugs, stress, surgical interventions, etc.;
- gastroduodenitis of erosive type;
- digestive disorders caused by increased acidity of gastric juice;
- therapy of reflux esophagitis;
- correction of Zollinger-Ellison syndrome;
- prevention of bleeding in the gastrointestinal tract;
- prevention of reflux of gastric contents (if general anesthesia is performed).

Features of using the medicine.

Instructions for use Famotidine states that the tablets are intended for oral consumption. The tablets must be taken exclusively whole. Chewing them, biting them into pieces, or crushing them in any other way is not recommended. The medicine must be washed down with a certain amount of ordinary clean water. The dosage is selected individually depending on the type of pathology and the individual characteristics of the patient.

Thus, when correcting ulcerative lesions of the gastrointestinal tract at the stage of exacerbation, the medicine can be used 40 mg once a day (in the evening) or 20 mg twice a day (in the morning and also in the evening). If necessary, the doctor may recommend increasing the dosage up to the maximum, which is 160 mg per day. The duration of Famotidine therapy can reach four to eight weeks.

If necessary, to prevent relapses of ulcerative lesions, patients should take 20 mg of medication in the evening, immediately before bed. The duration of prophylactic administration is two to three weeks.

Patients with reflux esophagitis are usually prescribed 20 mg Famotidine twice a day (morning and evening). If the disease is particularly severe, the single dosage can be increased to 40 mg. The duration of therapy reaches six weeks.

When correcting Zollinger-Ellison syndrome, it is necessary to begin therapy with the use of 40 mg of the drug at a time. Reception should be done at intervals of six hours. If the disease is severe, it is possible to increase the daily dosage to a maximum of 480 mg. The duration of therapy for this pathology is until the condition normalizes.

If Famotidine is used to prevent reflux of gastric contents during surgery, it is taken in an amount of 40 mg approximately an hour or two before the start of the operation. Sometimes doctors advise taking the appointment in advance - the day before.

Additional Information

It is important to consider that the use of Famotidine for therapeutic purposes should never be abruptly abandoned, because in such a situation the risk of withdrawal syndrome increases. The dosage must be reduced gradually and only over time the medication should be discontinued.

Famotidine is a representative of the group of histamine H2 receptor antagonists. The drug is often used to treat reflux esophagitis and peptic ulcers of the stomach and duodenum. Provides effective reduction of gastric acidity. The drug has its own contraindications for use and can provoke adverse reactions from various organs and systems. The drug is not recommended for use during pregnancy and breastfeeding.

Dosage form

The drug Famotidine is produced by pharmaceutical companies in the form of tablets intended for oral administration.

Description and composition

Famotidine tablets are round in shape, they are also biconvex and pale pink-gray in color. The tablet is white at the break.

The product contains a number of substances, the main one of which is famotidine in dosages of 20 and 40 mg, depending on the release form.

Among the auxiliary components there are:

corn starch;
microcrystalline cellulose;
silica;
talc;
magnesium stearate;
croscarmellose sodium.

The composition of the film shell includes:

hypromellose;
titanium dioxide;
lactose monohydrate;
macrogol 4000;
triacetin;
yellow dye (E172);
red dye (E172);
black dye (E172).

Pharmacological group

The drug belongs to the third generation H2-histamine receptor blockers. Famotidine inhibits basal, as well as histamine, acetylcholine and gastrin-induced secretion of hydrochloric acid. The pH level increases and pepsin activity decreases. There are no significant changes in the gastrin content in the blood serum. There is also a slight suppression of the cytochrome P450 oxidase system in the liver.

The onset of action of the drug occurs 60 minutes after administration, and after three hours the maximum is reached. The duration of action when used once lasts from 12 to 24 hours.

After oral use of the drug, rapid absorption from the gastrointestinal tract is observed. The maximum concentration in the blood serum is observed over a period of 1.5 to 5 hours. Bioavailability averages 40-45%. Famotidine is able to penetrate the placental barrier and also enter breast milk. The ability to bind to blood proteins ranges from 15 to 20%.

From 30 to 35% is metabolized in the liver.

The drug is excreted primarily through the kidneys; from 27 to 40% of the substance is excreted unchanged in the urine. The half-life reaches 2.5–4 hours.

Indications for use

The list of indications for taking the drug can be presented as follows:

stomach ulcer;
erosive gastroduodenitis;
reflux esophagitis;
Solinger-Ellison syndrome;
prevention of complications from stomach ulcers;
mastocytosis;
dyspeptic syndrome.

for adults

The composition can be used by patients in this group if there are indications for use. Before you start using the composition, you should consult a doctor.

for children

The product can be used in pediatric practice. The composition is prescribed to children over 3 years of age.

Pregnancy is a contraindication to the use of the product.

Contraindications

The list of contraindications to the use of the composition can be presented as follows:

children under 3 years of age;
pregnancy;
breastfeeding period;
hypersensitivity to the components of the product.

Applications and dosages

Famotidine tablets are taken orally; units of the drug must be taken with a small but sufficient amount of clean water. The dosage regimen differs significantly for patients with different indications.

for adults

Gastric and duodenal ulcers, erosive gastroduodenitis, symptomatic ulcers. Adult patients are prescribed 20 mg of the substance twice a day or 40 mg once a day before bedtime. It may be necessary to increase the dosage to 80-160 mg per day. The duration of taking the drug is from 4 to 8 weeks.

Dyspepsia associated with excessively active secretory function in the stomach and duodenum. For this pathology, it is recommended to take 1 tablet (20 mg) once or twice a day.

Prevention of recurrent peptic ulcers of the stomach and intestines. You need to take 20 mg (one unit of the drug) before bedtime.

Gastroesophageal reflux pathology. Adult patients with this disease are recommended to take 20-40 mg of the substance twice a day. The course of treatment ranges from 6 to 12 weeks.

Ulcerogenic pancreatic adenoma. The dosage regimen must be obtained from your treating specialist. In this case, it is installed individually. Typically the first dose is 20 mg every 6 hours and can then be increased to 160 mg every 6 hours. Preventive measures to combat gastric aspiration in the context of general anesthesia Adults are prescribed 40 mg of the drug in the evening or morning before a surgical procedure. The doctor may also consider it necessary to take both doses of 40 mg in the evening and in the morning.

Preventive measures against recurrent bleeding from the upper gastrointestinal tract. The medication is used twice a day, 20 mg. The duration of the course of therapy is from 3 to 4 weeks.

For patients with renal failure, the dose requires reduction.

for children

This medicinal product is not prescribed for children under 12 years of age. For older patients, the dosage regimen is similar to that prescribed for adult patients.

for pregnant women and during lactation

Side effects

The following adverse reactions may occur during the use of the medicinal composition:

decreased appetite;
the appearance of dryness in the oral cavity;
bad breath;
taste bud disorder;
the appearance of nausea;
gagging;
bloating;
diarrhea;
changes in liver tests;
headache;
increased fatigue;
noise in ears;
mental disorders;
arrhythmia;
agrunolocytosis;
pancytopenia;
leukopenia;
muscle pain;
alopecia;
acne;
dry skin.

Interaction with other drugs

Taking Famotidine can cause a decrease in the absorption of ketoconazole and.

When taken together with antacids and sucralfate, the absorption rate of famotidine decreases. The interval between doses should be at least 2 hours.

Famotidine inhibits the hepatic metabolism of phenazole, diazelam, theophylline, glipizide, calcium channel blockers, aminophenazole, hexobarbital, phenytoin, indirect anticoagulant drugs, buformin, caffeine, tricyclic antidepressants.

is a well-known antiulcer drug that is effective against the common intestinal bacterium Helicobacter pylori. The product has an astringent effect and affects all stages of the digestive chain. In most cases, the drug composition is well tolerated by patients, but there is a risk of side effects. The dosage and duration of use of the drug are determined privately together with the attending physician. Use during pregnancy and breastfeeding is possible if there are medical indications. The product can be used in pediatrics.

Gaviscon

Gaviscon is a medicine that has an enveloping effect. Once ingested, the composition forms a special film in the gastrointestinal tract. It is produced by pharmacological companies in several dosage forms: suspension and chewable tablets. It is worth noting that the effect of taking the suspension appears faster - 15-20 minutes after use and lasts for 8 hours. The drug is well tolerated by patients of various categories. If there are medical indications, it can be used during pregnancy and breastfeeding in limited doses selected by a specialist. There are no data on the use of the composition in pediatrics.

Ectis is a complex remedy that has a mild effect on the human body. The composition is able to activate the process of the digestive chain. The disadvantage of the composition is a large number of contraindications. There are no data on the safety of using the product during pregnancy and breastfeeding. The composition is prohibited for use in pediatric practice, since its effect on the children's body has not been fully studied.

Gastromax

This drug is a chewable tablet. The medication contains three active ingredients, one of which is famotidine, the others are magnesium hydroxide and calcium carbonate. The last two have a neutralizing effect on gastric acidity.

The active ingredient in this drug is. The product also produces an antiulcer effect. Available in tablet form. Indications for use generally coincide with the list of diseases for which Famotidine is prescribed

This medicinal product contains dicyclomine among the active ingredients. The drug is used for the same indications as the previous two. Available in tablet form.

Price

The cost of Famotidine is on average 55 rubles. Prices range from 13 to 100 rubles.

Timely treatment of a stomach ulcer can not only maintain a lifestyle without unpleasant restrictions, but also prevent the development of dangerous complications of the disease. Effective therapies include Famotidine tablets, which have helped many patients. Instructions for taking the drug contain information about the characteristics of the drug, side effects, method of administration and other important information that will help make the treatment effective.

Composition and release form

The drug is available in the form of film-coated biconvex tablets of two varieties: containing 20 (yellow) and 40 mg (pink) famotidine, the active substance. The tablets are packaged in blister packs with instructions for use. Composition of the drug:

Mechanism of action of Famotidine

The instructions for use of Famotidine contain information that it is a third generation histamine h2 receptor blocker. It suppresses the basal production of hydrochloric acid and that which is caused by the stimulating activity of histamine, gastrin and acetylcholine. Together with a reduction in the synthesis of hydrochloric acid, the drug increases the pH and reduces the activity of pepsin.

The medication cannot change the concentration of gastrin in plasma; it is a weak inhibitor of the liver cytochrome oxidase system. After administration, the effect of the tablets begins within an hour and reaches a maximum after three hours. With a single dose, the effect of the medication lasts 12–24 hours. Absorption of the drug begins in the gastrointestinal tract immediately.

The active substance of the composition reaches its maximum concentration after 1–3.5 hours. The medication has 40–45% bioavailability, which is slightly reduced in the presence of food and against the background of antacids. The active component binds to plasma proteins by 15–20% and penetrates the placenta barrier. A third of the dose is metabolized by liver cells to form oxide. Elimination occurs through the kidneys, 40% of the drug is excreted in the urine. The half-life is 2.5–4 hours, increasing with reduced creatinine clearance and renal failure.

Indications for use

The main indications for the use of Famotidine, according to the instructions, are peptic ulcer disease (treatment and prevention) and reflux esophagitis (inflammation of the esophageal mucosa due to the ingress of gastric contents onto it). In addition to these diseases, the drug is prescribed for diagnoses:

Zollinger-Ellison syndrome (a disease in which the appearance of a benign neoplasm on the pancreas is combined with ulcerative manifestations) - on the day of the intervention;
erosive gastroduodenitis;
prevention of aspiration of gastric juice during general anesthesia (Mendelssohn syndrome).

Directions for use and dosage

The prescription of a treatment regimen and selection of dosage is carried out by the attending physician on an individual basis. The main factor in stopping treatment should be the healing process of the ulcer. Withdrawal should be done gradually. The drug is mainly used in tablet form. The injections are acceptable for use in hospital settings and are prescribed to patients who, for one reason or another, cannot take the tablet form of Famotidine.

In case of exacerbation of peptic ulcer, tablets are prescribed once a day, 0.04 g. Famotidine is used twice a day, that is, 0.2 g at a time. The duration of the course of therapy should be from 4 to 8 weeks. To prevent and prevent exacerbations, Famotidine is taken in the evening (before bedtime) - 0.02 g. If there is high secretion of hydrochloric acid, the tablets are taken once a day, in the evening, the dosage is 0.02–0.04 g. If renal function is impaired, the dose is reduced doctor depending on the clearance values of creatinine and glycoprotein.

Preparations with famotidine solution

The initial dosage for adult patients should not exceed 20 mg twice daily. The prepared solution can only be administered intravenously. To prepare the solution, you need to dissolve the powder in 5-10 ml of sodium chloride (0.9%) (one ampoule). Administration should occur slowly over two minutes. If the drug is used as an infusion, the administration time should be 15–30 minutes. It is advisable to use the solution immediately after preparation.

For Zollinger-Ellison syndrome, the initial dose is 20 mg intravenously every 6 hours. Further, the dosage is selected individually. To prevent aspiration of stomach contents, 20 mg of the drug is administered to the patient before general anesthesia on the day of surgery (at least two hours before the intervention). To prepare a solution for infusion, it is permissible to use the following solutions:

sodium lactate;
dextrose;
dextrose with potassium;
Ringer's with lactic acid;
sodium chloride;
hydrocarbonate.

special instructions

The characteristics of the active substance led to the presence of the following special instructions when prescribing the drug:

Due to the fact that the drug is excreted mainly by the kidneys, caution is necessary when administered to patients with renal failure.
In the presence of cardiovascular diseases, it is recommended to take the drug through a long-term drip infusion.
The drug can be taken in combination with non-absorbable antacids. In this case, it is necessary to maintain an interval between taking these medications of at least two hours.
If the creatinine clearance is less than 30 ml/min or the plasma creatinine concentration reaches more than 3 mg per 100 ml, the daily dosage of Famotidine should be reduced to 20 mg or the dosing interval should be reduced to 36–48 hours.

Drug interactions

Famotidine is a drug that may interact with other medications. The instructions for use indicate the following combinations:

Due to an increase in the pH of gastric juice, the drug may reduce the absorption of Ketoconazole and Itraconazole.
Combining the product with antacids or Sucralfate reduces the intensity of its absorption, therefore, 1-2 hours should pass between doses of drugs.
The medication inhibits the metabolism of caffeine, phenytoin, phenazone, metronidazole, theophylline, and aminophenazone in the liver. It acts similarly in relation to Diazepam, Metoprolol, Hexobarbital, Lidocaine, Propanolol, indirect anticoagulants, Glipizide, Buformin. Reduces the effectiveness of tricyclic antidepressants and slow calcium channel blockers, increases the absorption of clavulanic acid and Amoxicillin. Their simultaneous combination is prohibited for NSAID gastropathy.
When Famotidine is combined with drugs that depress bone marrow, Aminophylline, neutropenia and hepatitis may develop.

Side effects of Famotidine

Hypersensitivity of the body can lead to the development of side effects. The probable ones include the following:

dyspeptic disorder of the digestive tract;
increased activity of liver enzymes (transaminases);
cholestatic jaundice, hepatitis;
asystole;
headaches, dizziness, hallucinations;
disturbance of taste, epigastric pain;
noise in ears;
myalgia and arthralgia;
skin rash;
pneumonitis;
carcinoma;
nosebleeds;
temperature increase;
imbalance in the composition of peripheral blood (agranulocytosis or thrombocytopenia, leukopenia);
bronchospasm;
amenorrhea, hyperprolactinemia, decreased libido, mastocytosis;
adenomatosis;
spasm of visual accommodation;
fragmentary (pattern) baldness;
blackheads

Overdose

If you take Famotidine in a dose that is higher than that recommended in the instructions, you may experience vomiting, motor agitation, tremor, tachycardia, collapse, decreased blood pressure, and hepatitis. Treatment of drug overdose consists of gastric lavage, taking sorbents, symptomatic therapy, and intervention with hemodialysis.

Contraindications

The drug Famotidine, according to the instructions for use, is prescribed with caution for liver and kidney failure, liver cirrhosis with a history of portosystemic encephalopathy, immunodeficiency, and the elderly. Contraindications to its use are age under 12 years and increased hypersensitivity to the components of the composition.

Terms of sale and storage

You can buy the medicine without a prescription. It should be stored in a dry, dark place away from children at a temperature not exceeding 25 degrees. The shelf life will be two years.

Famotidine analogs

There are analogues of Famotidine, which are similar to it in composition and therapeutic effect. Such substitutes include:

Gastromax - a drug that neutralizes the effect of acidic gastric juice, contains magnesium hydroxide, calcium carbonate, famotidine;
Gastrotide is a drug with the same effect and action;
Kvamatel – antiulcer tablets and solution for injection based on famotidine;
Ulfamide is a drug that reduces the secretion of gastric glands, with the same composition;
Famodinhexal is a histamine receptor antagonist, contains famotidine;
Famozol is a solution for the treatment of gastroesophageal reflux disease;
Famosan is an antiulcer tablet containing famotidine.

Famotidine or Omeprazole – which is better?

Compared to Famotidine, Omeprazole is available in capsules with micropellets, which reach their target faster. The active substance of the drugs is the same, they work on the same principle and have similar contraindications to the indications. The cost does not differ much, so the doctor must decide what is best for the patient. When prescribing, the individual characteristics of the patient are taken into account.

Famotidine price

The cost of the drug depends on the manufacturer, the number of tablets in the pack, and the seller’s pricing policy. Approximate prices on the Moscow pharmaceutical market:

Type of medicine	Manufacturer	Price, rubles
40 mg 20 pcs.
20 mg 20 pcs.
20 mg 30 pcs.
40 mg 20 pcs.
40 mg 20 pcs.	Hemofarm
20 mg 20 pcs.	Hemofarm

Famotidine is an antiulcer drug that, showing a persistent antagonistic hostility to histamine, blocks the “name” receptors of this mediator. By inactivating H2-histamine receptors of glandulocytes, it significantly reduces the secretion of hydrochloric acid caused by various stimuli. The effect of famotidine is dose-dependent, i.e. The higher the concentration of the active substance in the blood plasma, the more the basal and stimulated (caused by histamine, gastrin and acetylcholine) secretion of hydrochloric acid is suppressed. Simultaneously with the increase in pH, the drug reduces the activity of the digestive enzyme pepsin. After oral administration, the pharmacological effect of famotidine begins to develop after 1 hour and reaches its peak after 3 hours. The activity of the drug, as already mentioned, is strongly dependent on the dose and after a single dose can persist in a time range between 12 and 24 hours. Famotidine tablets are absorbed quite quickly from the digestive tract. The bioavailability of the drug depends little on food intake, but suffers when taking antacid drugs.

Famotidine is available exclusively in tablets. They should be taken without chewing, in doses prescribed by the attending physician, depending on the indications.

Gastric and duodenal ulcers in the acute phase require daily intake of 40 mg of the drug (you can take this dose 1 or 2 times, in the first case - at night). In the absence of the desired effect, it is allowed to increase the dose to 80-160 mg. The duration of the therapeutic course is 1-2 months. For dyspeptic symptoms caused by increased stomach acidity, a dose of 20 mg 1-2 times a day will be sufficient. In any case, the frequency of administration and dosage should be agreed with the gastroenterologist.

The disappearance of symptoms of a gastric and duodenal ulcer should not cause immediate discontinuation of the drug: treatment should be continued for another 7-14 days, after which it is necessary to conduct an endoscopic examination for scarring of the ulceration. Before therapy with famotidine, it is recommended to ensure that stomach pain is benign, because Gastric carcinoma may “masquerade” as an ulcer. Famotidine is characterized by “rebound” syndrome (deterioration of the clinical picture after abrupt discontinuation of the drug). While on a course of treatment with famotidine, you should refrain from drinking drinks and foods that irritate the gastric mucosa.

Pharmacology

III generation H2-histamine receptor blocker. Suppresses basal and histamine, gastrin and acetylcholine-stimulated production of hydrochloric acid. Simultaneously with the decrease in the production of hydrochloric acid and the increase in pH, the activity of pepsin also decreases. Does not significantly change the concentration of gastrin in plasma. Weakly inhibits the cytochrome P450 oxidase system in the liver. After oral administration, the effect begins within 1 hour and reaches a maximum within 3 hours. The duration of action of the drug after a single dose depends on the dose and ranges from 12 to 24 hours.

Pharmacokinetics

After oral administration, it is quickly absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved within 1-3.5 hours. The bioavailability of famotidine is 40-45%, changes slightly in the presence of food and decreases when taking antacids.

Communication with plasma proteins is 15-20%. Penetrates the placental barrier and is excreted in breast milk.

30-35% of famotidine is metabolized in the liver (to form S-oxide).

Elimination mainly occurs through the kidneys, 27-40% of the drug is excreted unchanged in the urine. T1/2 - 2.5-4 hours, in patients with creatinine clearance below 30 ml/min increases to 10-12 hours.

In patients with severe renal failure (creatinine clearance below 10 ml/min) it increases to 20 hours.

Release form

7 pcs. - contour cellular packaging (1) - cardboard packs.
7 pcs. - contour cell packaging (2) - cardboard packs.
7 pcs. - contour cell packaging (3) - cardboard packs.
7 pcs. - contour cell packaging (4) - cardboard packs.
7 pcs. - contour cell packaging (10) - cardboard packs.
10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (4) - cardboard packs.
10 pieces. - contour cell packaging (10) - cardboard packs.
14 pcs. - contour cellular packaging (1) - cardboard packs.
14 pcs. - contour cell packaging (2) - cardboard packs.
14 pcs. - contour cell packaging (3) - cardboard packs.
14 pcs. - contour cell packaging (4) - cardboard packs.
14 pcs. - contour cell packaging (10) - cardboard packs.
20 pcs. - contour cellular packaging (1) - cardboard packs.
20 pcs. - contour cell packaging (2) - cardboard packs.
20 pcs. - contour cell packaging (3) - cardboard packs.
20 pcs. - contour cell packaging (4) - cardboard packs.
20 pcs. - contour cell packaging (10) - cardboard packs.

Dosage

Take orally, without chewing, with plenty of water.

For peptic ulcers of the stomach and duodenum in the acute phase, symptomatic ulcers, erosive gastroduodenitis, 20 mg 2 times a day or 40 mg 1 time a day at night are usually prescribed. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

For dyspepsia associated with increased secretory function of the stomach, 20 mg is prescribed 1-2 times a day.

To prevent relapse of peptic ulcers of the stomach and duodenum: 20 mg once before bedtime.

For reflux esophagitis - 20-40 mg 2 times a day for 6-12 weeks.

To prevent aspiration of gastric juice during general anesthesia, 40 mg is prescribed in the evening and/or morning before surgery.

In case of renal failure, if CC is less than 30 ml/min or serum creatinine is more than 3 mg/100 ml, the daily dose of the drug should be reduced to 20 mg.

To prevent recurrent bleeding from the upper gastrointestinal tract - 20 mg 2 times a day for 3-4 weeks.

Overdose

Symptoms: vomiting, motor agitation, tremor, decreased blood pressure, tachycardia, collapse.

Treatment: gastric lavage, symptomatic therapy, hemodialysis.

Interaction

Due to an increase in the pH of the gastric contents, the absorption of ketoconazole and itraconazole may be reduced when taken simultaneously.

When used simultaneously with antacids or sucralfate, the absorption rate of famotidine decreases, so the break between taking these drugs should be at least 1-2 hours.

Inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, metoprolol, lidocaine, phenytoin, theophylline, indirect anticoagulants, glipizide, buformin, metronidazole, caffeine, blockers of “slow” calcium channels, tricyclic antidepressants. Increases the absorption of amoxicillin and clavulanic acid.

Bone marrow depressants increase the risk of developing neutropenia.

Side effects

From the digestive system: dry mouth, nausea, vomiting, abdominal pain, loss of appetite. In some cases, increased transaminase activity in the blood plasma.

From the nervous system: headache, dizziness, tinnitus, transient mental disorders.

From the cardiovascular system: rarely - arrhythmias.

From the hematopoietic organs: rarely - leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

From the reproductive system: with long-term use of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.

From the senses: accommodation paresis, blurred visual perception, ringing in the ears.

Allergic reactions: possible urticaria, skin itching, skin rash, bronchospasm.

Other: fever, arthralgia, myalgia.

Indications

treatment and prevention of relapses of gastric and duodenal ulcers;
treatment and prevention of symptomatic gastric and duodenal ulcers (associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), stress, postoperative ulcers);
erosive gastroduodenitis;
functional dyspepsia associated with increased secretory function of the stomach (including heartburn, sour belching);
reflux esophagitis;
Zollinger-Ellison syndrome;
prevention of recurrent bleeding from the upper gastrointestinal tract (GIT);
prevention of aspiration of gastric juice during general anesthesia (Mendelssohn syndrome).

Contraindications

children under 12 years of age (due to lack of sufficient experience in using the drug);
individual hypersensitivity to the components of the drug.

With caution: liver failure, liver cirrhosis with a history of portosystemic encephalopathy, renal failure, immunodeficiency, old age.

Features of application

Use during pregnancy and breastfeeding

Use during pregnancy is only possible if the potential benefit to the mother outweighs the risk to the fetus.

Passes into breast milk. During lactation, you should stop using the drug or stop breastfeeding.

Use for liver dysfunction

With caution in case of liver failure.

Use for renal impairment

With caution in case of renal failure.

Use in children

Contraindicated for children under 12 years of age.

special instructions

Symptoms of duodenal ulcer may disappear within 1-2 weeks, therapy should be continued until scarring is confirmed by endoscopic or x-ray examination. May mask symptoms associated with gastric carcinoma, so the presence of a malignant neoplasm must be excluded before starting treatment. Cancel gradually due to the risk of developing rebound syndrome with abrupt withdrawal.

With long-term treatment of weakened patients, as well as under stress, bacterial damage to the stomach is possible with subsequent spread of infection. H2-histamine receptor blockers should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant reduction in their absorption. Counteracts the effect of pentagastrin and histamine on the acid-forming function of the stomach.

Suppresses the skin reaction to histamine, thus leading to false-negative results (before conducting diagnostic skin tests to detect an immediate allergic skin reaction, the use of H2-histamine receptor blockers is recommended to be discontinued).

During treatment, you should avoid consuming foods, drinks and other medications that may irritate the gastric mucosa.

The effectiveness of the drug in inhibiting nocturnal gastric acid secretion may
decrease as a result of smoking.

Patients with burns may require an increase in the dose of the drug due to increased clearance.

If a dose is missed, it must be taken as soon as possible; do not take if it is time for the next dose; do not double doses.

Impact on the ability to drive a car and other mechanisms

There is no data on the effect of the drug on the ability to drive vehicles or perform work that requires concentration and increased attention.