Glutamic acid in cardiology. Increased need for protein

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fluffy speech: 1 tablet of L-glutamic acid 250 mg;

additional speeches: potato starch, povidone, stearic acid, calcium stearate;

husk: tsukor, light magnesium carbonate, povidone, anhydrous colloidal silicon dioxide, talc, titanium dioxide (E 171), patented barvnik blue V (E 131), visc yellow, oliya mineral light.

Pharmaceutical form

Tablets, covered with shell.

The main physical and chemical powers: round tablets with a biconvex surface, covered with a shell of black color. Two balls are visible on the cross section. On the surface of the tablets, blotches are allowed.

Pharmacotherapeutic group

Take care, scho blow on the nervous system. ATX code N07X X.

Pharmacological authorities

Pharmacodynamics.

A replacement amino acid that takes part in the processes of amino acid reamination in the body, in protein and carbohydrate metabolism, stimulates oxidation processes, contributes to the release of ammonia from the body, increases the stability of the body mu to hypoxia. Sprinkle the synthesis of acetylcholine and ATP, the transfer of potassium ions, plays an important role in the activity of skeletal ulcers. Glutamic acid belongs to neurotransmitter amino acids, which stimulates the transmission of excitation at the synapses of the central nervous system.

Pharmacokinetics.

Glutamic acid is well absorbed when taken internally. Shvidko is eliminated from the blood, accumulating more importantly in m "tongue and nerve tissues, liver and nirkah, penetrating through the blood-brain bar" and membrane clitin. Chastkovo glutamic acid for an hour of soaking is changed until alanine is dissolved. Under the influence of the enzyme glutamdecarboxylase, it transforms in the brain to a mediator - gamma-aminobutyric acid.

Close to 4-7% of the її is seen in the cross-section at the same time, the pit is utilized in the process of metabolic transformations.

Indication

Treatment of epilepsy, mostly small attacks with equivalents, somatogenic, involutional, intoxicating psychosis, reactive states with manifestations of depression, expulsion; with mental retardation in children, Down's disease, with infantile cerebral palsy, poliomyelitis (hostritis and early period), with progressive myopathy, for the usunennia and early neurotoxic manifestations, which can be caused by stagnation suvanni isoniazid and other drugs in the hydrazide group isonicotinic acid.

Contraindication

Hot spots, increased alertness, sharply pronounced psychotic reactions, liver and/or liver failure, nephrotic syndrome, biliary tract disease and duodenal ulcer, disease of the hematopoietic organs, anemia, leukopenia.

Interactions with other medical procedures and other types of interactions

One hour with thiamin and pyridoxine (drugs of vitamins of group B) Glutamic acid can be congested for the prevention and treatment of neurotoxic manifestations caused by the patient's treatment with GINK-group drugs (isonicotinic acid hydrazide) , for example, ftivazid, isoniazid).

With myopathy and m "ulcerative dystrophy, glutamic acid is effective in combination with pachycarpine and glycocol.

Features

Under the hour of rejoicing, it is necessary to systematically work on the completion of the slaughter and blood. In case of guilty side effects, it is recommended to change the dose of the drug. Glutamic acid can also be used to treat neurotoxic effects associated with other medications.

After taking Glutamic acid, rinse your mouth with a weak solution of sodium bicarbonate.

Lіkarsky zasіb vengeance tsukor, scho sled vrakhovuvat ill on tsukrovy diabetes.

Stagnation in the period of pregnancy or breastfeeding.

Dany likarsky zasib not zastosovuvat during the period of vagity and breastfeeding.

Zdatnіst vplivat on shvidkіst reaction when keruvannya motor transport or other mechanisms.

Vrahovyuchi possible injecting the drug into the nervous system, following the precaution of zastosovuvaty drug when cured by motor transport or robots with other mechanisms.

Method of stosuvannya that dose

We will grow older in a single dose of 1 g 2-3 times for production.

For children, one-time doses should be established: for 3-6 years - 250 mg, for 7-9 years - 0.5-1 g; vikom for 10 years - 1 g each.

Multiplicity of reception - 2-3 times for production.

In case of oligophrenia - 100-200 mg per 1 kg of weight of the sick body for a few months.

Take it 15-30 minutes before departure, with the development of dyspeptic manifestations - every hour or after departure.

The course of likuvannya - from 1-2 to 6-12 months.

Children.

Lіkarskiy zasіb not zastosovuvaty children up to 3 years old.

Overdose

Possibly stronger side reactions.

Likuvannya: The therapy is symptomatic;

Side reactions

From the side of the blood and lymphatic system: decrease in hemoglobin, leukopenia.

From the side of the shlunkovo-intestinal tract: vomiting, diarrhea.

From the side of the nervous system: head bіl, increased dratіvlivіst, sleeplessness.

From the side of the immune system: allergic reactions, including hanging on the ropes, sverbіzh, hyperemia.

The term of appurtenance

Wash away the savings

Store in original packaging at temperatures not exceeding 25°C.

Take care of the place inaccessible to children.

Package

10 tablets in blister packs.

10 tablets per blister, 3 blisters per pack.

Admission category

Over the counter.

Virobnik

JSC "KYIV VITAMIN PLANT".

Mіstseznahodzhennya virobnika i adresses mіstsya provadzhennya yogo activity

04073, Ukraine, m. Kiev, st. Kopilivska, 38.

Website: www.vitamin.com.ua.

INSTRUCTIONS

By medical use medicinal product

GLUTAMIC ACID

(GLUTAMIC ACID)

Compound

active substance: 1 tablet contains L-glutamic acid 250 mg;

Excipients: potato starch, povidone, stearic acid, calcium stearate;

shell: sugar, light magnesium carbonate, povidone, anhydrous colloidal silicon dioxide, talc, titanium dioxide (E 171), patent blue V dye (E 131), yellow wax, light mineral oil.

Dosage form. Coated tablets.

Main physicochemical characteristics: pills round shape biconvex surface, sheathed blue color. The cross section shows two layers. Inclusions are allowed on the surface of the tablets.

Pharmacotherapeutic group. Drugs acting on the nervous system.

ATX code N07X X.

Pharmacological properties

Pharmacodynamics.

Non-essential amino acid, which is involved in the processes of transamination of amino acids in the body, in protein and carbohydrate metabolism, stimulates oxidative processes, contributes to the neutralization and removal of ammonia from the body, increases the body's resistance to hypoxia. Promotes the synthesis of acetylcholine and ATP, the transfer of potassium ions, plays important role in skeletal muscle activity. Glutamic acid belongs to the neurotransmitter amino acids that stimulate the transmission of excitation in the synapses of the central nervous system.

Pharmacokinetics.

Glutamic acid is well absorbed when taken orally. It is rapidly eliminated from the blood, accumulating mainly in the muscle and nervous tissue, in the liver and kidneys, penetrates the blood-brain barrier and cell membranes. Partially glutamic acid during absorption it is transaminated to form alanine. Under the influence of the enzyme glutamate decarboxylase, it is converted in the brain into a mediator - gamma-aminobutyric acid.

About 4-7% of it is excreted in the urine unchanged, the rest is utilized in the process of metabolic transformations.

clinical characteristics.

Indications

Treatment of epilepsy, mainly small seizures with equivalents, somatogenic, involutional, intoxication psychoses, reactive states with symptoms of depression, exhaustion; at a delay mental development in children, Down's disease, cerebral palsy, poliomyelitis (acute and recovery periods), with progressive myopathy, to eliminate and prevent neurotoxic effects that may occur with the use of isoniazid and other drugs of the isonicotinic acid hydrazide group.

Contraindications

Feverish conditions, irritability, pronounced psychotic reactions, hepatic and / or kidney failure, nephrotic syndrome, peptic ulcer stomach and duodenum, diseases of the hematopoietic organs, anemia, leukopenia.

Interaction with other drugs and other types of interactions.

Together with thiamine and pyridoxine (preparations of B vitamins), Glutamic acid can be used to prevent and treat neurotoxic effects caused by the use of the patient medicines GINK-group (isonicotinic acid hydrazide, for example, ftivazid, isoniazid).

with myopathy and muscular dystrophy Glutamic acid is effective in combination with pachycarpine or glycocol.

Application features

During treatment, it is necessary to systematically conduct a study of urine and blood. When side effects it is recommended to reduce the dose of the drug.

Glutamic acid can also be used to relieve neurotoxic effects associated with taking other drugs.

Rinse your mouth after taking Glutamic Acid weak solution sodium bicarbonate.

The medicinal product contains sugar, which must be taken into account in patients with diabetes mellitus.

Use during pregnancy or lactation.

This medicinal product should not be used during pregnancy or lactation.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms.

Considering possible impact drug on the nervous system, the drug should be used with caution when driving vehicles or working with other mechanisms.

Dosage and administration

Adults appoint a single dose of 1 g 2-3 times a day.

children single doses are: 3-6 years - 250 mg, 7-9 years - 0.5-1 g; from 10 years old - 1 year.

Multiplicity of reception - 2-3 times a day.

With oligophrenia - 100-200 mg per 1 kg of the patient's body weight for several months.

Take 15-30 minutes before a meal, with the development of dyspeptic phenomena - during or after a meal.

The course of treatment is from 1-2 to 6-12 months.

Children.

The drug should not be used in children under 3 years of age.

Overdose

May increase the manifestations of adverse reactions.

Treatment: symptomatic therapy, gastric lavage, the use of enterosorbents.

Adverse reactions

From the blood and lymphatic system: decrease in hemoglobin content, leukopenia. From the side gastrointestinal tract: vomiting, diarrhea.

From the nervous system: headache, increased irritability, insomnia. From the side immune system: allergic reactions including rash, itching, flushing.

Best before date

Storage conditions

Store in original packaging at a temperature not higher than 25 ºС.

Keep out of the reach of children.

Package

10 tablets in blisters.

10 tablets in a blister, 3 blisters in a pack.

Manufacturer

JSC "Kyiv VITAMIN PLANT".

The location of the manufacturer and the address of the place of its activities.

04073, Ukraine, Kiev, st. Kopylovskaya, 38.

Website: www.vitamin.com.ua.

Amino acids.

Composition Glutamic acid

Active ingredient - Glutamic acid.

Manufacturers

Tatkhimfarmpreparaty (Russia)

pharmachologic effect

Neurotransmitter, stimulating metabolism in the central nervous system.

Participates in protein carbohydrate metabolism, stimulates oxidative processes, prevents a decrease in the redox potential, increases the body's resistance to hypoxia.

Normalizes metabolism by changing functional state nervous and endocrine systems.

It is a neurotransmitter amino acid that stimulates the transmission of excitation in the synapses of the central nervous system.

Participates in the synthesis of other amino acids, acetylcholine, ATP, promotes the transfer of potassium ions, improves the activity of skeletal muscles (is one of the components of myofibrils).

It has a detoxifying effect, promotes the neutralization and removal of ammonia from the body.

Normalizes the processes of glycolysis in tissues, has a hepatoprotective effect, inhibits the secretory function of the stomach.

When taken orally, it is well absorbed, penetrates through the BBB and cell membranes.

Side effects of glutamic acid

Hyperexcitability, insomnia, abdominal pain, nausea, vomiting, diarrhea, allergic reactions, chills, short-term hyperthermia; at long-term use- anemia, leukopenia, irritation of the oral mucosa, cracks in the lips.

Indications for use

Epilepsy (mainly small seizures with equivalents), schizophrenia, psychosis (somatogenic, intoxication, involution), reactive states that occur with exhaustion, depression, the consequences of meningitis and encephalitis, toxic neuropathy against the background of the use of isonicotinic acid hydrazides (in combination with thiamine and pyridoxine ), hepatic coma.

In pediatrics - mental retardation, cerebral paralysis, consequences of intracranial birth injury, Down's disease, poliomyelitis (acute and recovery periods).

Contraindications Glutamic acid

Hypersensitivity, fever, liver and / or kidney failure, nephrotic syndrome, peptic ulcer of the stomach and duodenum, diseases hematopoietic organs, anemia, leukopenia, irritability, rapidly flowing mental reactions, obesity.

Application restrictions.

Diseases of the kidneys and liver.

Method of application and dosage

Inside, 15-30 minutes before meals.

Adults and children 10 years and older - 1 g 2-3 times a day.

Children:

• up to 1 year - 0.1 g each, 1-3 years old - 0.15 g each, 3-4 years old - 0.25 g each, 5-6 years old - 0.4 g each, 7-9 years old - 0 each .5-1 g, 2-3 times a day;
• with oligophrenia - 0.1-0.2 g / kg.

The course of treatment is from 1-2 to 6-12 months.

Overdose

No data.

Interaction

The effectiveness of the use in combination with pachycarpine or glycine in progressive myopathy has been shown.

special instructions

During the treatment period, regular general clinical blood and urine tests are necessary.

If side effects occur, discontinue use and consult a doctor.

After oral administration in the form of a powder or suspension, it is recommended to rinse the mouth with a weak solution of sodium bicarbonate.

With the development of dyspepsia, take during or after meals.

Glutamic acid is a popular amino acid needed for muscle growth and immune support. It can be purchased at any sports shop. It makes up a quarter of the amount of all amino acids in the body. It is added to proteins.

This demand for the substance can be explained by the fact that it is inexpensive and has useful properties. Consider the instructions for the use of glutamic acid, as well as its beneficial properties.

Differences from glutamine

Glutamic acid is one of the many main components of all tissues, but it is contained in the brain most of all, its role is very important. If you introduce glutamate into the cerebral cortex, a powerful excitation reaction will follow.

In medicine, it has a psychostimulating and nootropic effect, helping with a number of diseases of the nervous system. It should be noted that glutamine and glutamic acid - different substances. The first is a recovery acid, the second is a stimulating acid. The acid is a precursor of glutamine. Muscles need glutamine.

Glutamic acid - an amino acid that has a nootropic effect, is necessary for the central nervous system. The brain uses it as a source of energy.

It is prescribed if it is necessary to correct behavioral disorders in children, for the treatment of epilepsy, muscular dystrophy, and so on. Glutamine production occurs in the brain. It neutralizes ammonia, there is a lot of it in the muscles, improves brain activity. Do not store in a humid place.

Glutamine is involved in the synthesis of other amino acids and performs many functions in the body, so it is worth consuming the appropriate supplements. The lion's share of amino acids in muscles comes from glutamine. Protects against poisoning of the liver, kidneys, inhibits the action of some drugs and activates the action of others.

If the supply of glutamine in the body is large, the muscles regenerate faster after strength and other activities. Most of all, glutamic acid is found in foods: milk, parmesan, then peas and duck meat.

Glutamic acid is replaceable, the body is able to independently provide its synthesis. A person can cover the need for this substance with conventional products nutrition, but the athlete needs it in large quantities.

Glutamine helps produce growth hormone, retains nitrogen in the body, delivers it to enzymes. With a negative nitrogen balance, aging begins. Helps potassium to penetrate deeper into muscle fibers.

Glutamine neutralizes ammonia, which destroys muscle cells. Growth hormone supports fat metabolism, muscle tissue growth. It becomes glucose in the liver, helping glycogen to accumulate.

Actions of glutamine:

• Energy source;
• Suppresses the secretion of cortisol;
• Strengthens immune forces;
• Allows the body to recover faster after a workout.

During exercise, the need for glutamic acid increases. It stops the breakdown of proteins.

Dosage form

L-glutamic acid is available in tablets. The drug activates the redox processes of the brain, affects protein metabolism, and:

1. Normalizes metabolism;
2. Neutralizes and removes ammonia;
3. The body becomes more resistant to hypoxia;
4. It has a good effect on the state of the nervous system;
5. Supports required amount potassium ions in the brain;
6. Reduces the secretion of gastric juice.

It is prescribed in the complex of many diseases associated with damage to the nervous system. Helps with epilepsy, schizophrenia, restless sleep and so on.

Dosage

Twice a day application of glutamic acid will provide the body with enough Substances: in the morning, after lunch. If the schedule is to visit the gym, then after fitness. Girls can take 5 g each, men - 10 g each. The substance is diluted with water, if in powder, or added to protein shakes.

They also take pills. If you take glutamine in season colds the risk of getting sick will decrease.

Receipt

Thanks to the salt of glutamic acid, monosodium glutamate, the tastes of products are enhanced, they are stored longer and do not lose their taste. Widely used in the canned industry. The substance is able to stimulate the function of the digestive glands.

Obtaining glutamic acid is carried out by hydrolysis of proteins. This classic way obtaining amino acids. Milk casein is used to obtain corn gluten, meat-packing waste and other proteins. This is an expensive method, since the acid must be carefully purified.

Another method of obtaining - microbiological synthesis. Some yeasts and bacteria are able to secrete this substance. But the method of obtaining with the help of bacteria is valued more.

The scheme for the production of glutamic acid is similar to that for the production of lysine, an essential acid.

They differ in the properties of the microorganism, the composition of the medium and other indicators. It is also an essential amino acid involved in the formation of collagen fibers and tissue regeneration. Needed for correct formation bones, helps to absorb calcium.

Analogues and synonyms

Along with glutamic acid, aspartic acid redistributes nitrogen in the body, neutralizes ammonia.

Epilapton is an analogue of glutamic acid. It also improves brain metabolism. Like glutamic acid, it affects protein metabolism, changes the functional state of the central nervous system.

On the basis of L-glutamic acid with glycine and L-cystine, the drug Eltacin was created, which increases the body's resistance to physical activity improves the quality of life of patients with heart disease.

In some cases, it is replaced by:

1. Glycine, which improves brain activity. It is prescribed for depression and nervous disorders. Glycine is designed to increase mental performance person;
2. Cortexin also has a nootropic effect. The cost is about 800 rubles. Improves concentration, learning process, strengthens memory;
3. Cytoflavin is also a nootropic that improves metabolism.

In sports

Participates in the synthesis of many different amino acids. Glutamic acid in sports is important and applicable for muscle growth and maintenance. It is able to retain moisture in the cells, forming a beautiful embossed body. The production of growth hormone increases, performance increases. It strengthens the immune system, which is important for athletes, since any illness will make it impossible to train for about a month.

In bodybuilding, they know that the faster the metabolism passes, the sooner you can bring the body to the cherished standard of professional form, and the above acid is a direct participant different types exchange. From it is formed aminobutyric acid that improves blood flow to the brain.

If the athlete decided to dry out and not lose muscle mass the dosage should be different. You need to follow a low carb diet. Muscle catabolism is not terrible if you take 30 g of glutamine per day. With a lack of carbohydrates, the body will suck out amino acids from the muscles, then it is impossible to strengthen them.

Daily intake in similar dosages strengthens the immune system.

Prices for glutamic acid in pharmacies can reach up to 200 rubles.

Formula: C5H9NO4, chemical name: L-Glutamic acid.
Pharmacological group: neurotropics/nootropics;
metabolites/proteins and amino acids/non-essential amino acid; funds for parenteral and enteral nutrition; detoxifying agents, including antidotes.
Pharmachologic effect: stimulating metabolism in the central nervous system, neurotransmitter.

Pharmacological properties

Glutamic acid is a non-essential amino acid that can be ingested with food, and also synthesized in the body during protein catabolism during transamination. Participates in carbohydrate and protein metabolism, does not allow a decrease in redox potentials, stimulates oxidation processes, increases the body's resistance during hypoxia. Glutamic acid normalizes metabolism by changing the functional state of the endocrine and nervous systems. It is also a neurotransmitter amino acid that stimulates the transmission of excitation in the synapses of the central nervous system. Participates in the formation of other amino acids, ATP, acetylcholine, helps in the transfer of potassium ions, improves performance skeletal muscle(is one of the components of myofibrils). Glutamic acid has a detoxifying property, promotes the excretion and neutralization of ammonia in the body. It improves the processes of glycolysis in tissues, reduces secretion in the stomach, and has a hepatoprotective effect. When used orally, it is well absorbed, penetrates through cell membranes and the blood-brain barrier. In the process of metabolism, it is utilized, 4-7% is excreted unchanged by the kidneys. Efficiency obtained sharing with glycine or pachycarpine in progressive myopathy.

Indications

Epilepsy (especially in small seizures with equivalents); psychoses (intoxication, somatogenic, involutional); schizophrenia; reactive states that occur with the phenomena of exhaustion; consequences of encephalitis and meningitis; depression; hepatic coma; toxic neuropathy when taking isonicotinic acid hydrazides (together with pyridoxine and thiamine); in pediatrics with mental retardation, cerebral palsy, consequences of childbirth intracranial injury, Down's disease, poliomyelitis (recovery and acute periods).

Method of application of glutamic acid and doses

Glutamic acid is taken 15-30 minutes before meals orally. Children from 10 years old and adults 2-3 times a day, 1 g; children: ; 7–9 years - 0.5–1 g, 2–3 times a day; 5–6 years - 0.4 g each; 3–4 years - 0.25 g each; 1–3 years - 0.15 g each; up to 1 year - 0.1 g; with oligophrenia - 0.1–0.2 g / kg. The duration of therapy is from 1–2 to 6–12 months.
If you skip the next dose of glutamic acid, take it, as you remember, then take glutamic acid through prescribed by the doctor from time to time last used. After ingestion in the form of a suspension or powder, it is recommended to rinse the mouth with a weak solution of sodium bicarbonate. When dyspepsia occurs, it is worth taking after or during meals. During therapy with glutamic acid, regular general clinical tests of urine and blood are necessary. With the development side effects it is necessary to stop taking the drug and consult a doctor.

Contraindications for use

Hypersensitivity, renal or liver failure, fever, nephrotic syndrome, diseases of the hematopoietic organs, peptic ulcer, leukopenia, anemia, irritability, obesity, violent psychotic reactions.

Application restrictions

Diseases of the liver and kidneys.

Use during pregnancy and lactation

You can use glutamic acid, but only when prescribed by a doctor.

Side effects of glutamic acid

Hyperexcitability, abdominal pain, insomnia, vomiting, diarrhea, nausea, allergic reactions, short-term hyperthermia, chills; with prolonged use - leukopenia, anemia, cracks in the lips, irritation of the oral mucosa.

Interaction of glutamic acid with other substances

Together with pyridoxine and thiamine, they are used for the treatment and prevention of neurotoxic phenomena, which are caused by the means of the isonicotinic acid hydrazide group (ftivazid, isoniazid, and others). In muscular dystrophy and myopathy, glutamic acid is more effective when used in conjunction with glycocol and pachycarpine.

Gross formula

C 5 H 9 NO 4

Pharmacological group of the substance Glutamic acid

Nosological classification (ICD-10)

CAS code

6899-05-4

Characteristics of the substance Glutamic acid

White crystalline powder sour taste. Slightly soluble in cold water, soluble in hot water(pH aqueous solution 3.4-3.6), practically insoluble in alcohol.

Pharmacology

pharmachologic effect- neurotransmitter, stimulating metabolism in the central nervous system.

A non-essential amino acid that enters the body with food, and is also synthesized in the body during transamination in the process of protein catabolism. Participates in protein and carbohydrate metabolism, stimulates oxidative processes, prevents the reduction of redox potential, increases the body's resistance to hypoxia. Normalizes metabolism, changing the functional state of the nervous and endocrine systems.

It is a neurotransmitter amino acid that stimulates the transmission of excitation in the synapses of the central nervous system. Participates in the synthesis of other amino acids, acetylcholine, ATP, promotes the transfer of potassium ions, improves the activity of skeletal muscles (is one of the components of myofibrils). It has a detoxifying effect, promotes the neutralization and removal of ammonia from the body. Normalizes the processes of glycolysis in tissues, has a hepatoprotective effect, inhibits the secretory function of the stomach.

When taken orally, it is well absorbed, penetrates through the BBB and cell membranes. Utilized in the process of metabolism, 4-7% is excreted by the kidneys unchanged.

The effectiveness of combined use with pachycarpine or glycine in progressive myopathy has been shown.

Application of the substance Glutamic acid

Epilepsy (mainly small seizures with equivalents), schizophrenia, psychosis (somatogenic, intoxication, involution), reactive states that occur with exhaustion, depression, the consequences of meningitis and encephalitis, toxic neuropathy against the background of the use of isonicotinic acid hydrazides (in combination with thiamine and pyridoxine ), hepatic coma. In pediatrics - mental retardation, cerebral palsy, the consequences of intracranial birth trauma, Down's disease, poliomyelitis (acute and recovery periods).

Contraindications

Hypersensitivity, fever, liver and / or kidney failure, nephrotic syndrome, peptic ulcer of the stomach and duodenum, diseases of the hematopoietic organs, anemia, leukopenia, irritability, violent psychotic reactions, obesity.

Application restrictions

Diseases of the kidneys and liver.

Side effects of glutamic acid

Hyperexcitability, insomnia, abdominal pain, nausea, vomiting, diarrhea, allergic reactions, chills, short-term hyperthermia; with prolonged use - anemia, leukopenia, irritation of the oral mucosa, cracks in the lips.

Substance Precautions Glutamic Acid

During the treatment period, regular general clinical blood and urine tests are necessary. If side effects occur, discontinue use and consult a doctor.