Monural analogues are inexpensive and high-quality drugs. Medicinal reference book geotar

1 package of Phosphoral contains 5.631 g of fosfomycin trometamol, which is equivalent to 3 g of fosfomycin.
Excipients: tangerine flavor, orange flavor, saccharin, sucrose.

Indications

Phosphoral is used to treat acute uncomplicated infections. urinary tract caused by microorganisms sensitive to fosfomycin. Prevention during diagnostic procedures and surgical interventions.

Contraindications

Contraindications to the use of Phosphoral are: hypersensitivity to the components of the drug, severe renal failure (creatinine clearance - 10 ml / min), hemodialysis.

Dosage and administration

Phosphoral is taken orally on an empty stomach. The content of the package is dissolved in 125 ml (1/2 cup) cold water, stir until completely dissolved and drink. The dosing regimen is set individually.
Usually single dose for adults in acute phase disease is 3 g (1 package) once.
To prevent urinary tract infection in surgical intervention, transurethral diagnostic tests take the contents of one package at 3:00 before the intervention and the second package - 24 hours after the intervention.
In more complex clinical cases(in elderly patients, with recurrent infectious diseases) or in case of infectious diseases caused by strains susceptible to antibiotic therapy in higher concentrations(Pseudomonas, Enterobacter, Proteus, indole-positive strains), a dose of 3 g is taken twice with an interval of 24 hours.

Overdose

The package contains 1 package of the drug, so the risk of overdose is minimal. In case of an overdose of Phosphoral, it is recommended to drink plenty of fluids (to increase diuresis). Application features.

Side effects

From the side digestive tract: diarrhea, nausea, heartburn.
Possible allergic reactions, skin rashes.
Severe hypersensitivity reactions, anaphylactic shock are rare.

Application during pregnancy

The use of Phosphoral during pregnancy and lactation is possible only for health reasons or if the expected effect of therapy for the mother outweighs the potential risk to the fetus / child. Adequate and strictly controlled studies on the use during pregnancy have not been conducted. Therefore, the ability of fosfomycin to cross the placenta should be considered. For the period of treatment should stop breastfeeding.

Storage conditions

Store in original packaging at a temperature not exceeding 30 ° C.

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Description of the drug "Phosforal" on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult a doctor and read the annotation approved by the manufacturer.

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cystitis - very unpleasant disease, which affects mainly women during menopause and pregnant women. In men, a disease associated with the urinary tract is called urethritis. Such problems require immediate treatment, as they cause discomfort.

Monural is a Swiss drug that has proven itself well and has comfortable shape applications. Monural has only one drawback - the price. It is good that there are analogues of the drug, both domestic and imported, which are similar in composition and action.

The active substance of Monural is Fosfomycin. Studies of the effect of this substance on the body have proven the safety of use for both adults and pregnant women, children.

Analogues of the drug according to the active substance

Exists a large number of domestic analogues of Monural, which are produced on the basis of fosfomycin. These include:

Ureacid

Release form - granules in a sachet for the preparation of a solution for oral administration.

Active ingredient - 1 sachet contains 3 grams of fosfomycin trometamol in terms of fosfomycin.

Antimicrobial antibacterial agent which is suitable for adults and children over 12 years old. Ureacid is used to treat simple infections caused by microorganisms sensitive to fosfomycin.

Mode of application

The contents of one sachet should be poured into ½ cup of cold water, stirred until completely dissolved and drunk immediately.

Usually a single dose for adults, including elderly patients in the acute phase of the disease, is 3 grams (1 sachet) once.

Side effects

Violation of the digestive tract, heartburn, nausea, diarrhea.

Contraindications

Hypersensitivity to the components of the drug, renal failure, elevated level creatinine in blood and urine.

Urolysin

Release form - granules for oral use.

The active ingredient is birch leaf extract, highlander herb, horsetail herb, saltwort herb, Kuril tea, black chokeberry fruits, blueberry shoots, burdock roots, glucose.

The drug is suitable for the treatment of uncomplicated urinary tract infections and for prophylaxis in diagnostic procedures and surgical interventions. The age category varies from 12 to 75 years.

Mode of application

• Dissolve 1 teaspoon of granules in 100 milliliters of warm water and take 3 times a day.
• The course of treatment is 4-6 weeks.
• After 2 weeks, repeat the course.

Use with caution in large kidney stones and gallbladder with exacerbations of urinary cholelithiasis more than 4 times a year.

Side effects

Disorders of the gastrointestinal tract.

Release form - powder for the preparation of a solution for intravenous administration of white or white with a yellowish tint.

Used for infectious inflammatory processes pelvic organs and exacerbations of diseases genitourinary system. Suitable for any age category starting with newborns. Minimally toxic.

Mode of application

It is necessary to prepare a solution for intravenous infusion. The cooking method will vary depending on the disease. Details can be found in the instructions inside the drug box.

Side effects

1. convulsions,
2. dizziness,
3. diarrhea,
4. chills,
5. skin irritations.

Contraindications

Hypersensitivity to fosfomycin, predisposition to allergic reactions, with liver diseases, with kidney failure, in heart failure, arterial hypertension.

Antibiotic a wide range action for systemic use in powder form for intravenous injections. Prescribed for treatment bacterial infections genitourinary system, gynecological and surgical infections. Not to be used by children under 5 years of age.

Mode of application

Side effects

Rarely nausea, vomiting, diarrhea,
Contraindications:

Release form - powder for the preparation of solutions for intravenous infusion.

Active ingredient - Fosfomycin (Fosfomycin), Trometamol.

It is a broad spectrum antibiotic. It is used in the treatment and prevention of diseases of the genitourinary system, acute bacterial cystitis, exacerbation of chronic recurrent bacterial cystitis, acute bacterial urovesical syndrome, bacterial nonspecific urethritis, asymptomatic massive bacteriuria.

Mode of application

The scheme of application is set individually for all ages and various diseases. Detailed instructions for preparing solutions for infusion can be found inside the package with the drug.

Side effects

Are rare

• nausea,
• vomit,
• diarrhea,
• skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Active ingredient - Fosfomycin (Fosfomycin), Trometamol.

A drug with a high antimicrobial action for treatment acute cystitis caused by drug-resistant Escherichia coli. Suitable for adults and children over 5 years old.

Mode of application

The drug is used once after emptying Bladder on an empty stomach, preferably at bedtime. For adults, the dosage is 3 grams, for children over the age of 5 years - 2 grams.

Side effects

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Release form - granules (powder) for solution (suspension).

Active ingredient - Fosfomycin (Fosfomycin), Trometamol.

Antibacterial agent of a broad spectrum of action in the form of a powder white color with a fruity odor for oral administration. Used to treat infectious and inflammatory diseases lower divisions urinary tract. Not recommended for children under 12 years of age. Released by prescription.

Mode of application

Side effects

Are rare

1. nausea,
2. vomit,
3. diarrhea,
4. skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Release form - granules (powder) for solution (suspension).

Active ingredient - Fosfomycin (Fosfomycin), Trometamol.

Broad-spectrum antibiotic for the treatment of acute uncomplicated diseases of the genitourinary system. It is also used for prophylaxis during diagnostic procedures and surgical interventions.

Mode of application

Taken inside. Single dose for adults - 3 grams, for children - 2 grams. The treatment regimen is set individually, taking into account the stage of the inflammatory process, the reactivity of the patient's body, the sensitivity of microorganisms to fosfomycin.

Side effects

• nausea,
• vomit,
• diarrhea,
• skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Release form - granules for oral solution preparation (packages) 2 grams, 3 grams.

The active substance is Nifuroxazide 100 milligrams, Fosfomycin (Fosfomycin).

Contains antibiotic, probiotic and fosfomycin. Used to treat acute and chronic cystitis and various diseases urinary tract. Suitable for adults and children over 12 years old.

Mode of application

It is used once, orally, on an empty stomach. A bag of granules must be dissolved in 100 milliliters of water and drunk. The use of the drug is possible babies only under medical supervision and in special cases.

Side effects

1. nausea,
2. vomit,
3. diarrhea,
4. skin rash that disappears on its own after discontinuation of fosfomycin.

Contraindications

Hypersensitivity to fosfomycin, pregnancy and lactation.

Description of the manual

The active substance of Monural is fosfomycin. It is included in the composition of the drug in the form chemical compound- trometamol. Active ingredient the drug has specific action for pathogens of cystitis. Fosfomycin inhibits the synthesis of the bacterial cell wall, which disrupts the vital activity of pathogenic microorganisms and causes their death.

The drug is relatively safe, as it exhibits a rather specific effect on bacterial enzymes, so there is no cross-drug resistance to it (a condition in which the resistance of pathogens to one drug extends to related drugs).

• The drug Monural is active against most gram-positive and gram-negative bacteria.
• Its spectrum of action includes common causative agents of cystitis - coli, Klebsiella, Morganella, pathogens of sexually transmitted infections.
• The drug interferes with one of early stages cell wall synthesis, which is why its spectrum of action is so wide.

How long does Monural work

When taking the drug inside, the active substance is absorbed from the digestive tract within an hour. Therapeutic concentration of the drug in the blood is achieved within 2-2.5 hours, in the urine - after 4-5 hours and lasts throughout the day.

A single dose is enough to create a bactericidal concentration of the drug in the blood, so Monural from cystitis helps from the first dose. Required concentration in urine active substance maintained during the day (in some cases - up to 48 hours).

The drug is excreted from the body mainly with urine, only about a quarter taken dose excreted through the intestines.

Release form

1. Monural is available in the form of a powder containing white mini-granules with a characteristic fruity odor that dissolves easily in water.
2. A solution for oral administration is prepared from the powder.
3. The drug is packaged in multi-layer paper bags laminated with polyethylene, 2 g or 3 g each, and 1-2 pieces are placed in cardboard packs.

Monural powder in addition to the main substance (fosfomycin) contains additional components- sugar, lactose, orange or tangerine flavor, which make the drug palatable.

There is no such form of release as Monural tablets or injection solutions.

Monural - official instructions for use

Registration number П N012976/01-110707

Trade name: Monural ®

international generic name

Dosage form

granules for the preparation of a solution for oral administration.

• 1 package contains: active substance - fosfomycin trometamol 3.754 g or 5.631 g (equivalent to 2.0 g or 3.0 g of fosfomycin);
• Excipients: tangerine flavor, orange flavor, saccharin, sucrose.

Description

Granules of white color with a smell of a tangerine.

Pharmacotherapeutic group

antibiotic

ATX code J01XX01.

Pharmacological properties

The active substance of Monural - fosfomycin trometamol - is a broad-spectrum antibiotic, a derivative of phosphonic acid.

Monural has a bactericidal effect. The mechanism of action is associated with the suppression of the first stage of the bacterial cell wall synthesis.

Being structural analogue phosphoenol pyruvate, enters into competitive interaction with the enzyme N-acetyl-glucosamino-3-o-enolpyruvyl transferase, resulting in specific, selective and irreversible inhibition of this enzyme, which ensures the absence of cross-resistance with other classes of antibiotics and the possibility of synergism with others. antibiotics (in vitro synergism with amoxicillin, cephalexin, pipemidic acid is noted).

The antibacterial spectrum of action of fosfomycin trometamol in vitro includes most of the usual gram-positive (Enterococcus spp., Enterococcus faecalis, Staphylococcus aureus, Staphylococcus saprophyt., Staphylococcus spp.) and gram-negative (E. coli, Citrobacter spp., Enterobacter spp., Klebsiella spp., Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Pseudomonas spp., Serratia spp.) pathogens. In vitro, fosfomycin trometamol reduces the adhesion of a number of bacteria to the urinary tract epithelium.

Absorption: Monural is rapidly absorbed from gastrointestinal tract at oral intake.

1. In the body, it dissociates into fosfomycin and trometamol. The latter does not have antibacterial properties.
2. Bioavailability with a single oral dose of 3 g ranges from 34 to 65%.
3. The maximum plasma concentration is observed 2-2.5 hours after oral administration and is 22-32 mg / l. The plasma half-life is 4 hours.

Distribution: Monural does not bind to plasma proteins, is not metabolized, mainly accumulates in the urine. Oral administration of a single dose of 3 g in the urine achieves a high concentration (from 1053 to 4415 mg / l), 99% bactericidal for most common pathogens of urinary tract infections.

The minimum inhibitory concentration of Monural for these pathogens is 128 mg/L. It is maintained in the urine for 24-48 hours, which suggests a single dose course of treatment. The concentration of Monural in the urine above the minimum inhibitory concentration for E. coli persists for at least 80 hours.

Excretion: Monural is 90% excreted by the kidneys unchanged with the creation of high concentrations in the urine. About 10% of the dose taken is excreted through the intestines unchanged. In patients with a moderate decrease in renal function (creatinine clearance

Indications for use

• Acute bacterial cystitis acute attacks recurrent bacterial cystitis;
• bacterial nonspecific urethritis;
• asymptomatic massive bacteriuria in pregnant women;
• postoperative urinary tract infections;
• prevention of urinary tract infection during surgery and transurethral diagnostic studies.

Contraindications

Individual hypersensitivity to fosfomycin trometamol, severe renal failure (creatinine clearance)

Use during pregnancy and lactation

During pregnancy, the drug is prescribed only when potential benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should stop breastfeeding for the duration of treatment.

Dosage and administration

inside.
The granules are dissolved in 1/3 cup of water. Monural is used once a day inside on an empty stomach 2 hours before or after a meal, preferably at bedtime, after emptying the bladder. Adults are prescribed 1 packet (3 g) 1 time per day.

In order to prevent urinary tract infection during surgery, transurethral diagnostic procedures, Monural is taken twice at the doses indicated above: 3 hours before the intervention and 24 hours after the intervention.

Children from 5 years to 18 years of age are prescribed in daily dose 2 g 1 time per day. The course of treatment is 1 day. In more severe cases (elderly patients, recurrent infections) take 1 more packet 24 hours later.

In case of renal insufficiency, reduce the dose and lengthen the intervals between injections.

Side effect

Possible disorders of the gastrointestinal tract (nausea, heartburn, diarrhea), skin rash, allergic reactions.

Overdose

Overdose symptoms: diarrhea. If persistent diarrhea occurs, it is recommended symptomatic treatment.

The risk of overdose is minimal, since Monural is available in a package of 1 or 2 bags. In case of an overdose, oral fluid intake is recommended to increase diuresis.

Interaction with other drugs

Simultaneous administration with metoclopramide should be avoided, as this may lead to a decrease in the concentration of Monural in the blood serum and in the urine.

special instructions

Simultaneous reception food slows down the absorption of Monural - it is necessary to use the drug 2 hours before or after meals.

Patients with diabetes should be aware that 1 package of Monural with a dosage of 2 g or 3 g of fosfomycin contains 2.100 g or 2.213 g of sucrose, respectively.

Release form

Granules for the preparation of a solution for oral administration 2 g and 3 g. 6 g or 8 g of the drug are placed in bags of 4-layer laminated foil (paper-polyethylene-aluminum-polyethylene). 1 or 2 bags are placed in a cardboard box along with instructions for use.

Storage conditions

List B. Store at a temperature not exceeding 30 ° C. Keep out of the reach of children.

Best before date

3 years. Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies

On prescription.

Manufacturing company

Zambon Switzerland Ltd., Via Industria 13, CH-6814 Cadempino, Switzerland.

Claims for the quality of the drug should be sent to the address: Representative office of Zambon Group S.A. JSC. (Italy): Russia, 121002 Moscow, Glazovsky per., 7, office 17.

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When is Monural prescribed?

The main area of ​​​​application of Monural is the treatment of bacterial cystitis and urethritis (inflammation of the urethra).

Powder Monural 3g is used for acute course diseases or prescribed as part of complex treatment chronic infectious processes V urinary system. The use of the drug is also justified in acute recurrent attacks of the disease. In addition, Monural is prescribed for the following conditions:

• massive bacteriuria of pregnant women, asymptomatic;
• urinary tract infections in the postoperative period.

In order to prevent the drug is prescribed after surgery on the urinary tract or during medical and diagnostic procedures (when placing a catheter or cytoscopy).

1. Monural is equally effective in both women and men. Reviews of the use of Monural for cystitis show its exceptional effectiveness and rather high safety.
2. The drug is allowed to be used at almost any age, and its use in pregnant and lactating women is also allowed, since no negative effect of the active substance on the fetus or breast-fed infant has been recorded.

Monural is recommended to be taken on an empty stomach, after dissolving one sachet of medicine (3g) in a third of a glass of warm water. This should be done in the evening (before going to bed), two hours after the last meal and after emptying the bladder.

A single dose of the drug is enough to eliminate the symptoms of cystitis and destroy the pathogens.

• With a recurrent form of the disease, the doctor may recommend a second dose of Monural a day after taking the first dose of the antibiotic.
• The same treatment regimen is used for elderly patients.
• If Monural is prescribed for prophylactic purposes, a single dose of the drug is taken 3 hours before the diagnostic procedure or operation or one day after the intervention.

How much to drink Monural with a recurrent course of cystitis or urethritis depends on the severity of the disease. The need for repeated use of the drug becomes clear a day after the first dose. If the symptoms of the disease persist, you need to take another dose. In total, you can take the drug up to three times.

In patients with renal insufficiency, the treatment regimen must be adjusted - to reduce the dose of the drug and increase the time interval between taking the solution. Sometimes this drug prescribed for pyelonephritis to prevent descending infection. In this case, Monural and tablets are taken simultaneously against the causative agents of the underlying disease.

There is a special form of release of Monural for children, in which the dosage of the active substance is not 3, but 2 grams. The drug is used in children over 5 years of age and adolescents. The treatment regimen is the same as in adult patients - it is necessary to dissolve a bag of powder in a third of a glass of water and drink it at night. If the drug does not help, you can not give it again.

Taking Monural during pregnancy

The impact of any drugs during pregnancy is undesirable, so the best option is to engage in the prevention of diseases, rather than their treatment. But if a woman is still ill, without medical preparations not enough.

Monural - strong antibiotic, the entire course of treatment for them may consist of a single dose of the solution. And, although doctors say that this is better than using drugs for a week or two, women are very worried whether such a powerful effect will be harmful to the child.

The instructions for Monural indicate that it can be used in pregnancy when the expected maternal health benefits are greater than possible risk for the fetus.

Many doctors agree that the drug can be prescribed during the period of bearing a child, since there was no connection between taking Monural and the occurrence of pathologies in the development of the embryo.

But still, the instructions indicate that the risk exists, albeit potential. Therefore, absolutely safe drug cannot be named. In addition, during treatment with Monural during breastfeeding, it is recommended to suspend it for several days so that the antibiotic does not get to the baby with milk.

The drug cannot be unambiguously attributed to either the list of permitted or the list of drugs prohibited during pregnancy.

There are no reliable clinical data on the effect on the fetus. Therefore, pregnant women should not take Monural without a doctor's prescription, based only on their well-being or based on the experience of friends.

Based on the results of the diagnosis, the specialist is able to assess the severity of the disease, how high the risk of complications is, and make the best selection medicines for the expectant mother.

Despite the lack of accurate data, today Monural is considered one of the safest antimicrobial drugs.

Advantage of Monural

The advantage of Monural over others similar means in that the number of his receptions is minimal. During this time, it does not cause significant disturbances in the work of the intestines and does not have time to have a detrimental effect on the stomach.

But keep in mind that the first trimester is the most dangerous period for taking any medication. Basic systems are being formed and internal organs fetus, the woman's body has not yet fully adapted to the new state, so Monural is on early dates pregnancy is prohibited.

The active substance of the drug enters bloodstream, which means that it can easily penetrate the placental barrier.

In the next two trimesters, the risk of any unwanted effects is minimal, but still taking Monural, you must follow the instructions exactly and follow the dosage of the drug.

mama66.ru

How to take Monural during pregnancy? The dosage of the drug for expectant mothers practically does not differ from that for other groups of patients.

1. Adults are prescribed a single dose of a solution prepared from 1 sachet of granules (3 g).
2. Re-application a day later may be required in case of severe or recurrent infection, as well as in the elderly.
3. To prevent the development of complications during surgical intervention in the organs of the urinary system and transurethral examinations, Monural is prescribed in two doses: 1 sachet 3 hours before the procedure, the other one a day after the first.

With caution, Monural is used to treat patients with renal insufficiency, since excess funds are excreted in the urine. Such patients require a reduction in a single dose and an increase in the interval between doses.

To prepare the product, the contents of the sachet are stirred, dissolved in a third of a glass of water. You need to take Monural on an empty stomach, a couple of hours after eating or for the same period of time before it. It is better to drink the solution before going to bed, after emptying the bladder.

Contraindications

There are few contraindications for taking Monural. These include severe and recurrent forms of thrush, renal failure (acute and chronic), accompanied by a decrease glomerular filtration.

Hypersensitivity to the components of the drug may also be noted, in which case it is prohibited to prescribe Monural. The medicine is not intended for children under five years of age. With fungal and bacterial lesions occurring simultaneously, Monural should be administered together with antifungal agents so as not to worsen the patient's condition.

Adverse reactions

• Adverse reactions when taking Monural can be manifested by the appearance of skin rashes (in persons with hypersensitivity) or violations by digestive system(nausea, heartburn, vomiting or diarrhea).
• If similar symptoms are pronounced, it is advisable to replace Monural with analogues that do not cause such side effects.
• In less severe cases, to eliminate dyspepsia, it is enough to increase the amount of fluid consumed.

An overdose of the drug is extremely rare. If it does occur, the patient is prescribed forced diuresis - an increase in the amount of fluid consumed along with the intake of diuretics. There is no specific antidote, the need for hospitalization or resuscitation usually does not occur.

FAQ

1. How long to take Monural? In most cases, a single dose of the drug is sufficient. If necessary, the doctor may recommend taking the powder three times a day at intervals (in adults). In children, re-admission is unacceptable.
2. Can Monural be taken with thrush? If thrush is combined with bacterial cystitis, then it is possible combined treatment under the supervision of a physician. In other cases, the use of an antibiotic can increase the manifestations of thrush.
3. Why Monural with pyelonephritis? With inflammation renal pelvis there is a risk of descending infection - the introduction of pathogens with urine into the bladder and urethra. To avoid this complication, the doctor may prescribe Monural.
4. Monural did not help, what should I do? Take the medicine again. If there is no improvement even after repeated antibiotic use, consult a doctor. Most often, the lack of effectiveness is due to the fact that cystitis is non-bacterial in nature or infectious agents are insensitive to the active substance.
5. Does Monural help men? The drug is equally effective in cystitis, urethritis and bacteriuria in both sexes. The dosage for men and women is the same, the method of application is the same.
6. How to use Monural in teenagers? Children's Monural can be used up to 18 years old, that is, it is permissible to prescribe it to adolescents. In some cases, the doctor may individually select for treatment adult form drug.

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Analogues by mode of action

These drugs act on the body in a similar way as Monural.

Release form - capsules of 0.5 milligrams for oral use.

The active substance is Amoxicillin (Amoxicillin).

Broad-spectrum penicillin antibiotic. Available in the form of capsules (orally) and granules for suspension. It is used to treat infectious diseases. Suitable for adults and children over 12 years old. The course of treatment is from 5 to 12 days.

Mode of application

Adults and children over 12 years of age take 500 milligrams 3 times a day.

Side effects

Dizziness, ataxia, allergic reactions, pruritus. skin redness, fever, rhinitis, conjunctivitis, anaphylactic shock.

Contraindications

1. Infectious mononucleosis,
2. lymphocytic leukemia,
3. severe gastrointestinal infections, accompanied by diarrhea or vomiting,
4. respiratory viral infections,
5. allergic diathesis,
6. bronchial asthma,
7. hay fever,
8. hypersensitivity to penicillins and / or cephalosporins.

Nolicin

The active active ingredient of Nolicin is Norfloxacin. It is a Gram-negative second-generation fluoroquinolone capable of producing high therapeutic concentrations in the urine. Bactericidal activity is due to inhibition of DNA gyrase, suppression of synthesis and destabilization of DNA chains in a microbial cell.

Norfloxacin is effective against:

• staphylococci;
• causative agents of gonorrhea;
• Escherichia coli;
• proteus;
• citrobacter;
• klebsiella;
• enterobacter;
• salmonella;
• some intracellular pathogens
• Haemophilus influenzae, etc.

It does not affect streptococci, enterococci, spirochetes, listeria and anaerobes, it is weakly effective against chlamydia and mycoplasma.

Nolicin is produced by the Slovenian pharmaceutical company - Krka.

Contraindications

1. individual intolerance to fluoroquinolones;
2. hemolytic anemia;
3. age less than eighteen years;
4. pregnancy and lactation;
5. severe disorders of cerebral circulation and atherosclerosis;
6. damage to the nervous system;
7. malignant myasthenia gravis;
8. photosensitivity;
9. heart rhythm disturbances;
10. epilepsy;
11. kidney or liver failure.

Undesirable effects from the use

• dyspeptic disorders;
• dysfunction of the liver;
• allergic reactions;
• glomerulonephritis;
• antibiotic-associated diarrhea and pseudomembranous colitis;
• inflammation and rupture of the tendons;
• leukopenia;
• dysbacteriosis;
• fungal infections of the oral mucosa and vagina;
• violation of the heart rhythm;
• photosensitivity.

Long-term therapy with fluoroquinolones should be carried out under constant monitoring of the coagulogram, general and biochemical analyzes blood.

Due to the pronounced increase in skin sensitivity to ultraviolet radiation, direct exposure should be avoided. sun rays and use creams with high SPF protection.

Interaction with other drugs

Treatment of patients taking oral hypoglycemic drugs should be carried out with caution, under strict control of sugar levels. This is due to the ability of Nolicin to enhance the effect of sugar-lowering agents.

• It is forbidden to simultaneously prescribe fluoroquinolones and glucocorticosteroids, due to a pronounced increase in toxic action on ligamentous apparatus. The effect of this interaction is especially pronounced in elderly patients.
• When Norfloxacin is combined with non-steroidal anti-inflammatory drugs, it is possible to increase the neurotoxic effect, up to the development of seizures.
• When combined with drugs that have hypotensive action, possible reduction blood pressure up to collapse.

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Urolesan

Release form - syrup in glass bottles with a volume of 15 milliliters, in the form of tablets or capsules.

The active substance is Trilon-B and essential oils.

A bactericidal preparation is used:

1. with stones in the bladder;
2. with stones in the gallbladder;
3. with salt diathesis;
4. with pyelonephritis in acute or chronic form;
5. with cholecystitis;
6. with inflammatory processes in the tissues of the liver and bile ducts;
7. with dyskinesia of the gallbladder.

Mode of application

Adults and children take 1 capsule or 10 milliliters of syrup, 3 times a day before meals.

Side effects

Nausea, dizziness, heartburn, diarrhea.

Contraindications

Individual intolerance to the components of the drug, gastric and intestinal ulcers, glomerulonephritis, gastritis of all forms.

Urfocin

Release form - granules for the preparation of a solution for oral administration (packages) 3 grams.

The active ingredient is Fosfomycin.

Ukrainian broad-spectrum antibiotic for systemic use. Suitable for the treatment of mild urinary tract diseases. Indicated for adults and children over 12 years of age.

Mode of application

Dissolve one sachet of the drug in ⅓ cup of water. Take 1 time per day on an empty stomach a few hours before meals, after emptying the bladder beforehand.

Use during pregnancy and lactation only under medical supervision.

Side effects

• Heartburn,
• nausea,
• diarrhea,
• headache,
• skin rash.

Contraindications

Age less than 12 years, allergy to the components of the drug, renal failure, women who are breastfeeding.

Release form - paste for oral administration 100 g in metal (aluminum) tubes.

The active substance is aqueous extracts from onion peel, wheatgrass root, parsley fruit, herb mountaineer, herbs horsetail, birch leaves, fenugreek seeds, goldenrod herb, hernia herb, lovage root.

A drug plant origin based on water-alcohol extracts of herbs and essential oils. Used for treatment chronic diseases urinary system.

Mode of application

Apply 1 teaspoon of paste 3-4 times a day. The course of treatment is from 2 to 6 weeks.

Side effects

1. nausea,
2. diarrhea,
3. vomit,
4. skin rashes,
5. temporary loss of taste.

Contraindications

Individual intolerance, children under 15 years old, pregnant and lactating women.

Furadonin

Release form - tablets of 100 milligrams.

The active substance is Nitrofurantoin.

A drug that is used to treat bacterial cystitis and chronic inflammation Bladder.

Mode of application

Take 50-100 milligrams of the drug 3-4 times a day. The tablet should be taken with plenty of liquid.

Side effects

• Allergy,
• cough,
• dyspnea,
• itching and redness of the skin,
• drowsiness,
• headache,
• nausea,
• loss of appetite,
• vomit.

Contraindications

Hypersensitivity to fosfomycin, predisposition to allergic reactions, liver diseases, renal failure, heart failure, arterial hypertension, cirrhosis, hepatitis, lactation.

An Indian drug produced by the Ranbaxy campaign. The cost of a package of 20 tablets of 400 mg is about 300 rubles.

It surpasses the Slovenian Norfloxacin in the quality of raw materials and is lower in cost (20 tablets of Nolicin will cost 430 rubles).

Norbactin is highly effective in the treatment of infectious and inflammatory lesions of the urinary tract of bacterial etiology, as well as prostatitis, cervicitis, endometritis, uncomplicated gonorrhea and traveler's diarrhea.

Dosages and method of application

1. For maximum effectiveness from the use of an antibiotic, it is recommended to use it 2-3 hours before a meal.
2. In the treatment of uncomplicated acute cystitis, the intake of 0.4 grams of Norbactin every 12 hours is indicated. The course of therapy is three days.

Treatment of infectious and inflammatory diseases of the urinary tract in acute period lasts from seven to ten days, depending on the location and severity of the disease. With frequently recurring or chronic infections the drug is used for a course of up to a month.