ACC - instructions for use. How to drink effervescent tablets, powder or cough syrup for adults and children ACC

Most diseases are always accompanied by a cough, so it is understandable that there is a desire to get rid of it faster. The range of anti-influenza and expectorant drugs is wide. How to make the right choice? Not every medication is suitable for treating dry or wet cough. Likewise, ACC cannot always be used.

ACC - indications for use

The medicine ass is a mucolytic, expectorant and detoxifying agent prescribed for severe coughs in children and adults. This drug is capable of not only thinning mucus, but also effectively removing it from the lungs and bronchi, relieving inflammation, and improving the functioning of the body’s secretomotor functions. The ACC instructions state that it can be used if you have the following health conditions:

• acute or chronic bronchiolitis and bronchitis;
• sinusitis;
• asthma;
• pneumonia;
• pulmonary eczema;
• tuberculosis;
• otitis media;
• cold.

Even this is not all the possibilities of the ACC. Due to its medicinal properties, the drug is often used for cystic fibrosis - hereditary disease caused by a gene mutation. In addition, it is often prescribed for the treatment of mild or prolonged inflammatory processes of the nasopharynx: tracheitis, acute rhinitis, nasopharyngitis, sinusitis, which are accompanied by the accumulation of a large amount of purulent mucus.

For what cough is ACC prescribed?

If you already have a package of the product in your house, then before going to the pharmacy, you can independently study for which cough you drink ACC. However, complex medical terms and phrases will not be understandable to everyone. Doctors recommend taking the medicine for a wet, productive cough - when excess viscous or too thick sputum accumulates in the bronchi.

ACC – at what age can it be given to children?

Many young mothers ask: is it possible to give ACC to children and at what age? To which experienced pediatricians answer with confidence: not only is it possible, but it is necessary. The main thing is to do it correctly:

• A child from 2 years to 6 years old can only be given ACC 100 mg, which is available as a powder.
• Starting from 7 years of age, treatment with ACC 200 mg is allowed. This medicine can be found in granules.
• ACC 600 is available for children 14 years of age and older. Unlike other medications, this type of medication is effective for 24 hours.
• As a syrup, the medicine can be given to infants, but only under the supervision of a pediatrician.

Method of using ACC

For convenience, many pharmaceutical companies They began to produce the medicine in several forms: granules, for example, with orange flavor, instant tablets, syrup. Each form has its own doses and limits on how to take ACC:

• It is extremely rare that the solution is prescribed for inhalation. If the nebulizer used for the procedure is equipped with a distribution valve, then you need to use 6 ml of a 10% powder solution. If there is no such supplement, doctors recommend taking a 20% solution at the rate of 2-5 ml per 1 liter of water.
• For bronchoscopy, severe rhinitis, and sinusitis, the use of ACC intratracheally is allowed. To clean the bronchi and sinuses, use a 5-10% solution. The diluted liquid must be dripped into the nose and ears in a volume of up to 300 mg per day.
• When using the parenteral method, ACC is administered intramuscularly or intravenously. In the latter case, the ampoule must be diluted with sodium chloride or dextrose in proportions of 1 to 1.

ACC-long - instructions for use

ACC tool marked long is different from regular tablets or powder in that the effect of it lasts not 5-7 hours, but the whole day. The medicine is produced in the form of large effervescent tablets and is intended for oral administration, 1 tablet 1 time per day, unless otherwise recommended by a doctor. Additionally, along with the medicine, you need to drink up to one and a half liters of liquid, which enhances the mucolytic effect.

How to breed ACC Long:

1. Pour clean, chilled boiled water into a glass and place a tablet at the bottom.
2. Wait until the effervescent effect wears off and the capsule dissolves completely.
3. Once dissolved, drink the solution immediately.
4. Sometimes before drinking ACC, the diluted drink can be left for several hours.

ACC powder - instructions for use

ACC powder is used in the following doses:

• adolescents over 14 years of age and adults are prescribed up to 600 mg of acetylcysteine, the dose is divided into 1-3 approaches;
• it is recommended to give a child under 14 years of age the same dose of the drug, but divided into several doses per day;
• Children under 6 years old can be given 200-400 mg of powder per day.

Both adults and children should drink ACC powder after meals, and the composition from the bag must be properly prepared. What water to dissolve ACC in depends on your preference, but remember: best result will be achieved if you dilute the medicine with half a glass hot water. However, baby granules with orange flavor can be dissolved in lukewarm, boiled water.

ACC effervescent tablets - instructions for use

Acetylcysteine ​​effervescent tablets are diluted with water using the same system as regular powder. The dose of the drug, in the absence of other doctor’s recommendations, is:

• for colds infectious diseases, occurring in a mild form, adults - 1 tablet ACC 200 2-3 times a day, for 5-7 days;
• for chronic cough, bronchitis or cystic fibrosis, the medicine is taken for a longer period, and its dose for adults is 2 capsules of ACC 100 three times a day.

ACC syrup for children - instructions

Sweet ACC syrup is prescribed to children aged two years and older for the diagnosis of colds. light form or chronic bronchitis. The medicine is taken orally for 5 days, immediately after meals. The dosage of syrup is chosen by the attending physician. If no recommendations have been received from the pediatrician, then the guide will be ACC - the official instructions for use from the manufacturer, which states that you can take the medicine:

• adolescents: 10 ml 3 times/day;
• if the child is from 6 to 14 years old, then 5 ml 3 times a day;
• for children 5 years old, the dose of the medicine is 5 ml 2 times a day.

Remove the baby syrup from the bottle using a measuring syringe. The device comes complete with the medicine. Instructions for using the syringe are as follows:

1. Press the bottle cap and turn it clockwise until it clicks.
2. Remove the cap from the syringe, insert the hole into the neck and press the syringe until it stops.
3. Turn the bottle upside down, pull the syringe handle towards you, measuring required dose syrup.
4. If bubbles appear inside the syringe, lower the plunger slightly.
5. Slowly pour the syrup into the child's mouth and allow the child to swallow the medicine. Children should stand or sit while taking the drug.
6. After use, the syringe should be washed without soap.

Analog of ACC

If you are looking for a cheap analogue of ACC cough medicine, pay attention to the following medicines:

• Ambroxol, country of origin: Russia. Contains the same active ingredient and belongs to the category of mucolytic expectorants. Its price is about 40-50 rubles.
• Fluimucil, country of origin: Italy. Designed to eliminate the first signs of a cold and cough, but can be used to ease the discharge of viscous secretions from the nose. Its composition consists of 600 mg of acetylcysteine, citric acid, sorbitol and flavorings. The price of the drug is about 300 rubles.
• Ambrobene, country of origin - Germany. It is produced as a syrup based on another active substance – ambroxol hydrochloride. The medicine helps to cope with a protracted, poorly expectorated cough, removes mucus from the bronchi, and softens the respiratory tract. Its price ranges from 200 to 300 rubles.

Price of ACC for cough

The form of release not only contributed to the freedom of choice of the buyer, but also significantly influenced how much ACC costs in pharmacies. More often, its price is very reasonable, which makes the medicine accessible to every social class of the population. However, in different cities and pharmacies, prices for medicine may vary slightly. The average cost of the drug is:

• baby syrup – price up to 350 rubles;
• granular ACC - up to 200 rubles;
• powder – 130-250 rubles;
• orange and honey flavored powder – price from 250 rub.

ACC - contraindications

Contraindications to the use of ACC are as follows:

• individual intolerance to the active substance;
• increased sensitivity to additional components medicines;
• illness during pregnancy, during lactation, excluding artificial feeding;
• ulcer duodenum and stomach;
• liver failure;
• history of pulmonary hemorrhage.

In addition, it is highly undesirable to use the medicine together with other cough syrups, bronchodilators and antibiotics that contain codeine and inhibit expectorant reflexes. Those who have previously been diagnosed with venous enlargement of the veins, diseases of the adrenal glands or abnormalities in the functioning of the endocrine system should take the medicine with caution.

Side effects of ACC

Overdose symptoms and side effects of ACC appear as:

• allergic reactions: itchy skin, urticaria, dermatitis, laryngeal edema, anaphylactic shock;
• deterioration of health: muscle weakness, drowsiness, ringing in the ears, rapid heartbeat, migraine;
• stool disorder: severe diarrhea;
• indigestion: nausea, heartburn, gag reflex after taking pills.

Video: ACC annotation

ACC - reviews

Anton, 54 years old

I suffered from cough for a long time. I can’t say that he was dry, but the phlegm still didn’t come out. I decided to go to the hospital and the doctor advised me to try ACC Long in effervescent tablets. I took the course as stated in the instructions for the medicine - 5 days. The cough has not gone away at all, but breathing has become much easier, and phlegm is already coming out of the bronchi.

Anastasia, 32 years old

At the beginning of treatment for a wet, persistent cough, a friend advised me to try ACC powder. When I came to the pharmacy, at first I was confused because of the price of the medicine. It cost somewhere around 130 rubles, which is very strange and inexpensive compared to its analogues. I decided to try it anyway and was not mistaken, the cold went away in 3 days, and my breathing returned to normal.

Cough medicines do not inhibit the body's reflex reaction aimed at cleansing the bronchi. They are necessary to eliminate the cause of this occurrence. unconditioned reflex– irritation from accumulated discharge.

Antitussive drugs (Sinekod, Libexin), which are prescribed to combat painful coughing attacks, are distinguished by their ability to suppress the cough reflex.

Antitussive drugs are prescribed in the absence of mucus in the respiratory tract and scanty discharge.

A wet cough is not treated with antitussives. If there is a large accumulation of mucus, their use interferes with the removal of mucus; the patient can literally suffocate due to blockage of the respiratory tract with secretions.

Used for cough and bronchitis wide range tablets of different names natural, synthetic origin. Most often doctors prescribe for bronchitis:

Cough preparations

Inflammation of the bronchi is treated with medications containing bromhexine, ambroxol or acetylcysteine ​​as the active substance. These synthetic compounds are more effective than drugs plant origin, such as Mukaltin.

Bromhexine and analogues

The action of the substance is based on the destruction of polysaccharides that are part of sputum, due to which it liquefies. The active component bromhexine is found in large number drugs, included, for example, in:

We described in detail how bronchitis is treated in adults when there is no fever in a separate article.

Ambroxol analogs

The synthetic substance ambroxol is a derivative of bromhexine, used in inflammatory processes, and is used as a mucolytic with anti-inflammatory properties. Ambroxol is contained in medications:

Ambrobene is considered an effective remedy for thinning sputum with scanty secretion. Preparations containing ambrobene improve the separation of mucus from the surface of the bronchi and stimulate its elimination.

Products containing acetylcysteine ​​(ACC)

Medicines with ACC are prescribed for viscous sputum to thin it, better discharge. Drugs containing ACC are used for purulent bronchitis and cough with thick discharge, which is possible due to the ability of acetylcysteine ​​to remain active in the presence of pus and blood.

ACC, like ambroxol, is a vital necessary medications, is available for sale in every pharmacy, and its prices must be controlled by the state.

For bronchitis, effervescent tablets with acetylcysteine ​​are used:

Tablets with acetylcysteine ​​are not prescribed to children under 14 years of age, and are not used simultaneously with antitussives due to the danger of sputum stagnation.

For the treatment of all types of bronchial inflammation, the most commonly used drugs are ACC, Bromhexine, Fluimucil. These medications help remove mucus from the bronchi with increased mucus secretion.

Tablets with herbal ingredients

When mucus secretion increases, the combination drug Bronchipret will help cope with the increasing volume of sputum and speed up its elimination. This medicine belongs to natural preparations of plant origin; it contains primrose extract and thyme.

With minor sputum discharge, a positive effect is achieved by using Travisil absorbable tablets. The manufacturers of this product have provided for the treatment of people suffering from diabetes by releasing Travisil, which does not contain sugar.

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Is it possible to take ACC and Bromhexine at the same time?

In theory, it’s possible. Both bromhexine and acetylcysteine ​​promote the evacuation of mucus from the lungs. In the annotation, I did not see that these drugs interacted with each other in any way. For example, bromhexine is not recommended for use with medications that suppress the cough center, as this will lead to stagnation of sputum and the proliferation of bacteria in the secretion. But acetylcysteine ​​works differently.

Personally, I haven't come across combination drugs with acetylcysteine ​​and bromhexine. But bromhexine itself is not an active substance and it begins to work only after a change in the liver, where it is converted into ambroxol. But drugs that contain both acetylcysteine ​​and ambroxol exist. For example, Pulmobreeze.

No you can not. Why should you take two mucolytic drugs at the same time? This is impractical and even dangerous. You don’t take ketorol, nise and diclofenac for pain at the same time, do you? Choose one drug and take it according to the instructions. Personally, I like ACC better.

These two drugs, ACC and bromhexine, have approximately the same effect and cope well with wet coughs, although judging by the price, ACC will still be more expensive. It’s true that it’s more pleasant to drink; for example, it’s much easier to persuade my child to drink it ACC bag than a bromhexine tablet.

Well, the taste is also different, it will be better.

As it is, both drugs do their job well, so there is simply no point in using them at the same time; the cough will definitely not go away twice as fast.

You can take it together, but why?

The drugs ACC and Bromhexine do not conflict with each other, so it is prohibited joint reception no, but the question is, why take them together? Double medicine means double side effects, double harm. Only a doctor can decide whether it is worth intensifying treatment with another antitussive drug or whether you can get by with one and only it will help. Of course, there are cases when a doctor may prescribe taking both ACC and bromhexine, but this is rather an exception, and you cannot make such a decision on your own, without a doctor.

If the cough goes deep down and it’s hard to breathe, then of course you can - I had this happen once and the doctor recommended that I do just that, so as not to take an antibiotic - it worked out, so to speak Double punch for cough and this is exactly what helped me cope.

Of course, the effect of the medicine is the same.

Is it possible to take ACC and Bromhexine at the same time and which is better?

Cough syndrome is an inevitable companion to acute respiratory infections, the number of pharmacological drugs that help fight it is very large, and sometimes, when coming to a pharmacy and looking at the window, a person thinks: ACC or Bromhexine, which is better to help cope with a cough? Both of these medicines have an antitussive purpose, but at the same time, each of them has its own subtleties in terms of pharmacological action, which must be taken into account when using them. Experts are well acquainted with them, so it would be better to leave the right of choice to the attending physician.

What are the similarities and differences between these commonly used cough remedies?

Bromhexine has been sold on the Russian pharmacological market for more than 15 years and is well known to both doctors and patients.

The main forms of the drug are available in the form:

• solution for injection;
• solution for internal use;
• dragee;
• drops;
• syrup;
• tablets.

All of them, with the exception of the first, intended for intravenous administration, taken orally, i.e. enter the body by ingestion, and are prescribed by doctors to adults and children in order to correct the painful condition that occurs during acute respiratory viral infections, one of the symptoms of which is cough.

Acetylcysteine ​​(ACC) is a newer antitussive drug compared to Bromhexine, but has already proven itself to be effective in adults and children. It is available in two main forms: in the form of syrup and granules dissolved in boiled water.

Children agree to drink both forms very willingly thanks to good taste medicine flavored with orange additive. In addition, effervescent granules, dissolving in water, make the medicine similar to a fruit drink.

Experts consider it acceptable to take ACC, like Bromhexine, starting from the age of 2 years.

As for infants, these medications should be given to them with great caution and only under the supervision of a doctor. Increased mucus production may cause suffocation in an infant whose respiratory function is imperfect, and coughing skills have not yet been formed, therefore, to facilitate the process, experts recommend giving the child a chest drainage massage while taking antitussive medications.

pharmachologic effect

Main active ingredient Bromhexine is the hydrochloride of this substance, which is mucolytic (thinning sputum), antispasmodic (relieving spasmodic reaction smooth muscle bronchi, causing cough) and expectorant action. It is usually prescribed for:

• pharyngitis;
• laryngitis;
• acute and chronic forms of bronchitis;
• inflammation of the tracheal mucosa, causing tracheitis or tracheobronchitis;
• acute and chronic inflammation lungs.

In all these diseases, a characteristic symptom is a dry, unproductive cough without expectoration, which injures the inflamed mucous membrane of the respiratory tract. Bromhexine is used to relieve such symptoms. Its use during illness helps to quickly transform cough syndrome from dry and unproductive to moist, productive form, and when wet form– it is better to cough and remove mucus from the respiratory tract, which is nutrient medium for pathogenic microorganisms. The effect is achieved, among other things, by activating the ciliary mechanism of the epithelium, which ensures improved pumping of air masses. This cleaning significantly speeds up the process of normalizing functions breathing apparatus after a person has suffered acute respiratory viral infections.

The effect of ACC on the body is almost the same, therefore the indications for use are the same. In addition, it is recommended for use with such serious illness like cystic fibrosis.

Dosage, side effects, contraindications

In children under six years of age, the use of Bromhexine is permitted in liquid form.

The approximate dosage is:

• for a child from two to six years old – 4 mg three times a day;
• from six to fourteen – 8 mg three times a day.

The adult dose can be equal to 16 mg per double dose.

Tablet forms are intended for children aged six years and older, as well as adult patients. Their volume is 1-2 tablets three times a day. Specific recommendations regarding dosage are given by the attending physician.

The duration of the course should be at least 10, but not more than 14 days. As a rule, the positive effect appears on the third to fifth day, but if you have been taking the medicine for a week without noticing any positive dynamics, you should discuss with your doctor the advisability of taking it.

Taking the drug in any form is contraindicated:

• children under two years of age;
• women in the first trimester of pregnancy and during breastfeeding;
• persons who have individual intolerance to the components included in the drug.

Side effects may include headache, dizziness, nausea, vomiting, diarrhea, skin rash. When similar symptoms You should immediately stop taking the medication and consult a supervising specialist.

The dosage of ACC also depends on the age of the patients. Adults and adolescents from 14 years of age are allowed to take 200 mg of the drug 2-3 times a day, from six to 14 years old - 100 mg three times a day, or 2 times 200 mg, from two to six - 100 mg twice per day. The attending physician calculates the dose for patients with cystic fibrosis on an individual basis, depending on the severity of the condition.

The course of treatment for ARVI is 5-7 days; for chronic forms, its duration is determined by a specialist.

List of contraindications, in addition to age under two years, pregnancy, lactation and individual intolerance, includes esophageal varices, bronchial asthma, renal and liver failure, as well as diseases that may result in hemoptysis.

Many patients wonder: what will happen if they take Bromhexine and ACC together, and is it possible to do this? Experts' opinions on this matter vary, and there is no categorical prohibition. But, since their action is, in principle, the same plan, it is not advisable to use both medications at once.

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Our immunity is directly dependent on our lifestyle and nutrition. Only a small part of it is initially genetic. Throughout life, a person acquires immune deficiency, which subsequently leads to various kinds diseases, allergic reactions and poor health. By taking care of your diet, you will also take care of your immunity, which will subsequently save you from many health problems. This test will show you what to pay attention to in your current diet. What to add, what to reduce, and what should be abandoned completely.

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Something needs to be changed urgently!

Judging by your diet, you don’t care about your immune system or your body at all. Most likely, you get sick often, suffer from intestinal problems, and are haunted by the feeling constant fatigue. It's time to love yourself and start improving. It is urgent to adjust your diet, to minimize fatty, starchy, sweet and alcoholic foods. Eat more vegetables and fruits, dairy products. Nourish your body by taking vitamins and drinking more water(precisely purified, mineral). Strengthen your body, reduce the amount of stress in life, think more positively and move to healthy eating It will be much easier, you just need to start.

Your immune system is in fairly good condition.

So far, it’s good, but if you don’t start taking care of her more carefully, health problems may begin (if the prerequisites haven’t already existed). Namely, allergies, frequent colds, intestinal problems and other “charms” of life accompany weak immunity. You should think about your diet, minimize fatty, flour, sweets and alcohol. Eat more vegetables and fruits, dairy products. To nourish the body by taking vitamins, do not forget that you need to drink a lot of water (precisely purified, mineral water). Strengthen your body, reduce the amount of stress in your life, think more positively and your immune system will be strong for many years to come.

Congratulations! Keep it up!

You care about your nutrition, health and immune system. Continue in the same spirit and health problems will not bother you for many years to come. Don't forget that this is mainly due to the fact that you eat right. Eat proper and healthy foods (fruits, vegetables, fermented milk products), do not forget to use a large number of purified water, harden your body, think positively. Just love yourself and your body, take care of it and it will definitely reciprocate your feelings.

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How often do you eat fast food?

• Few times a week
• Once a month
• Several times a year
• I don't eat at all

Do you eat healthy and nutritious food?

• Always
• I strive for this

How often do you eat foods containing high amounts of sugar?

• Daily
• Few times a week
• Once a month or less
• I don't use it at all

Are you spending fasting days or any other cleaning procedures?

• 1-2 times a week
• Several times a month
• Several times a month

How many times a day do you eat?

• Less than 3 times
• Breakfast lunch and dinner
• More than 3 times

What type of people do you consider yourself to be?

• Optimist
• Realist
• Pessimist

How often do you eat baked goods and pasta made from light flour?

• Daily
• Few times a week
• Several times a month or less

Do you eat a varied diet?

• I eat a variety of foods, but the same dishes for many years

What products do you have for breakfast?

• Porridge, yogurt
• Coffee, sandwiches
• Other

What time do you have breakfast?

• Before 7.00
• 07.00-09.00
• 09.00-11.00
• Later 11.00

Do you have food intolerances?

Do you take vitamins?

• Yes, regularly
• Every season
• Very rarely
• I don't accept it at all

How much pure water do you drink per day?

• Less than 1.5 liters
• 1.5-2.5 liters
• 2.5-3.5 liters
• More than 3.5 liters

Have you ever had a food allergy?

• I find it difficult to answer

What portions do you eat?

• While it fits
• I'm still a little hungry
• I eat up, but not to the point of being full

Are you taking antibiotics?

• In case of urgent need

How often do you eat vegetables and fruits?

• Daily
• Few times a week
• Very rarely

What kind of water do you drink?

• Mineral
• Cleaned with household appliances with filters
• Boiled
• Raw

How often do you consume fermented milk products?

• Daily
• Few times a week
• Once a month or even less often

Do you always eat at the same time?

Is it possible to take bromhexine and ACC at the same time?

When treating cough, it is necessary to use drugs that affect all mechanisms of cough pathogenesis. Bromhexine suppresses the activity of the cough center, ACC is a drug that suppresses the peripheral cough mechanism.

So bromhexine and ACC are the most competent combination of antitussives.

As a rule, taking one drug does not help, because it falls out therapeutic effect to one of the pathological parts of cough.

ACC - cheap analogues (list), instructions, comparison of effectiveness

Cough is the body’s reaction to absolutely various diseases respiratory tract, often of an inflammatory nature. Sometimes it goes away on its own and does not require outside help. But, with a weakened immune system, the cough drags on for a long time, tormenting the patient and causing him a lot of inconvenience.

There are many drugs for the treatment of inflammatory pathologies of the bronchopulmonary system, one of which is ACC. It is used to treat dry and wet (wet) coughs, both in adults and in pediatrics. ACC is a safe and popular remedy that has repeatedly proven its effectiveness in the fight against viscous sputum, but due to its high cost, cheap analogues of ACC are becoming popular. Pharmacological affiliation – mucolytic, ATX code: 05CB01.

Basic properties, composition and release form of ACC

Acetylcysteine, the main substance of ACC, has a pronounced anti-inflammatory, expectorant, thinning and antioxidant effect. The main task of the drug is to liquefy and remove difficult-to-separate mucus from the respiratory tract. By cleansing the bronchi, inflammation is relieved, cough is eliminated, and the protective function of the mucous membrane is restored.

ACC for dry cough is most in demand, so there is no doubt whether to purchase the drug or not. It is necessary to help the bronchi clear away as quickly as possible from sticky mucus, which impedes the patient’s recovery. A cough is not able to expel such phlegm, so mucolytics will be required. ACC and its analogues, cheap or more expensive, allow the bronchopulmonary system to free itself from accumulated mucus and get rid of cough.

For ease of use, the drug is available in different forms. Patients can use effervescent tablets, hot drink(prepared from powder), solution (base – powder). One of the latest innovations from Salutas Pharma GmbH (Germany) is a ready-made syrup, which is available in bottles of 100 and 200 ml.

By taste qualities ACC has variety. There are forms with orange, cherry, lemon and blackberry flavors.

The effect of ACC begins on the first day of administration, and on the second day patients note that they have wet sputum and already have something to cough up. The feeling of tightness, pain, and other unpleasant symptoms in the sternum decrease.

For what pathologies is ACC used?

The drug is used for all diseases accompanied by the accumulation of viscous, thick and difficult to separate sputum in the bronchi. Such pathologies include:

• acute and chronic bronchitis;
• COPD (chronic obstructive pulmonary disease);
• pneumonia;
• bronchial asthma(mild to moderate);
• bronchiectasis;
• lung abscess;
• tracheitis and laryngotracheitis;
• cystic fibrosis ( systemic disease, in which the secretion of mucus in the body is disrupted);
• sinusitis;
• inflammation of the middle ear.

For the treatment and prevention of runny nose, sore throat, ARVI and influenza in children and adults, Elena Malysheva recommends the effective drug Immunity from Russian scientists. Thanks to its unique, and most importantly 100% natural composition, the drug has extremely high efficiency in the treatment of sore throats, colds and strengthening the immune system.

How to dose the drug correctly?

Depending on the disease, the severity of symptoms and the age of the patient, ACC doses may vary.

Thus, in case of cystic fibrosis, maximum daily dose up to 800 mg, while the patient’s body weight should not be less than 30 kg.

Infants (from the third week of life) and children under 2 years of age are prescribed up to 150 mg per day, divided into 50 mg doses. Children from 2 to 5 years old are allowed to give up to 400 mg per day (we divide the drug into 4 doses). After 6 years, the maximum daily dose increases to 400–600 mg per day, and is also divided (three doses per day).

For uncomplicated cough, the course of treatment with ACC is a week. If necessary (chronic diseases), the drug is used for up to 6 months.

ACC is dissolved in liquid (100 ml), it is better to use water, but you can also use compote, juice, cool tea. Take after meals. Doctors do not recommend drinking ACC before bed, because... increased mucus outflow, even in horizontal position, may worsen cough. Therefore, the last dose should be immediately after dinner (around 18:00).

Instructions for use of ACC prohibit the use of the drug in the following cases:

• intolerance to acetylcysteine ​​and all complementary components;
• severe allergy history;
• bleeding from lung tissue;
• tendency to bronchospasm;
• hypotension;
• hemoptysis;
• fructose intolerance;
• ulcerative processes of the gastrointestinal tract;
• hepatitis and more severe kidney disease in children.

The following negative reactions are possible while taking ACC:

• a sharp decrease in blood pressure;
• headache;
• the appearance of tinnitus;
• nausea, diarrhea;
• stomatitis;
• itchy dermatoses;
• tachycardia;
• attack of suffocation;
• other.

Clinical trials of ACC did not reveal a negative effect of the drug on the fetus, but it is not recommended for use at all stages of gestation and during breastfeeding.

If the patient is not satisfied with the price or side effects occur, ACC can always be replaced with cheaper analogues, both domestic and foreign. In this case, it is better to use medications with another active ingredient, because structural analogues With high probability will cause the same unwanted symptoms.

ACC - cheap analogues for children and adults

To determine which analogues will be cheaper, let's first take a look at some prices for ACC:

• orange granules No. 20 – 140 rubles;
• syrup 200 ml – 350 rubles;
• syrup 100 ml – 225 rubles;
• ACC 200 tablets No. 20 – 250–320 rubles;
• ACC Long 600 mg effervescent tablets No. 10 – about 400 rubles.

The most popular analogue of ACC is the Swiss drug fluimucil. It is a structural analogue and has much in common with ACC, even their price is the same.

1. You can buy cheaper, for example, acetylcysteine ​​produced in Estonia (Vitale-HD). At a lower price you can also buy drugs ambrohexal, ambrobene or domestic drug ambroxol. These products have another active substance – ambroxol.
2. Bromhexine is also considered a cheap analogue of ACC. The price for 100 ml of syrup (Russia) is 80 rubles, produced in Latvia – 125 rubles.
3. Popular, but more expensive analogues, Ascoril and Lazolvan are considered.

To change the drug, always contact the specialist who prescribed the cough treatment. If this is not possible, you will have to work a little on your own. To do this, you need to take the instructions for the main drug, in our case it is ACC, and compare it with the intended substitute.

Many instructions already provide a hint in the form of a list of potential analogues. The main thing is to pay attention to the list of warnings, indications, as well as age, especially when therapy is needed for a child. In principle, you need to conduct a comparative assessment and highlight all the advantages of the analogue.

What is better - ACC or its analogues? This concept has its own relativity, because For one patient, for example, ACC will be suitable, and for another, a product with a different composition will be suitable. The clinical picture of the disease, the use of concomitant medications, chronic pathologies in the anamnesis - all this together affects the exact determination of the right drug. That's why without medical education It is not advisable to conduct experiments on yourself and your loved ones.

By comparing drugs, you can only highlight the pros and cons in order to better navigate the choice of analogues, as well as purchase a less toxic and more effective product.

ACC or Lazolvan – which is better to choose?

The drugs differ in their composition, therefore, they are not structural analogues. The active substance of ACC is acetylcysteine, while the main component of lazolvan is ambroxol. Funds are issued different countries. ACC is produced by companies in Slovenia and Germany, and lazolvan is produced by France, Germany, Spain and Greece.

In terms of the number of dosage forms, Lazolvan has an advantage; it has five of them, while ACC has only three.

Both drugs have a pronounced mucolytic effect, i.e. They liquefy sputum, but their mechanism of “work” is different. Unlike lazolvan, ACC also exhibits antitoxic and antibacterial effects.

Sometimes the drugs in question are prescribed in parallel. One drug is taken orally, the other is used inhalation.

In pediatric practice, lazolvan is successfully used from a very early age, and ACC, starting from two years of age (for cystic fibrosis from birth). Lazolvan is often used for inhalation, so some pediatricians prefer it.

The price of drugs depends not only on the dosage form, but also on the country of origin. In general, the products under consideration are close in price, and may differ by up to 20%, and in some pharmacies lazolvan is more expensive, in others, on the contrary, ACC is more expensive.

What is better ACC or Ambrobene?

The drugs differ in their composition, but they have the same pharmacological affiliation - mucolytics. The active component of ambrobene is ambroxol hydrochloride.

The variety of dosage forms of Ambrobene (there are five of them) is an advantage over ACC.

According to recent studies, it has been established that ambrobene has antiviral activity, has a mild analgesic effect, relieves inflammation, and removes toxins. Studies have also shown that ambroxol hydrochloride slows the spread of the harmful protein alpha-synuclein, which causes the progression of severe illnesses like Parkinson's disease.

Despite how ACC method and Ambrobene work, their main task is the same - to rid the patient of thickened sputum.

The combined use of these drugs is also acceptable. This combination is indicated when the disease takes on more serious forms.

According to the observations of pediatricians, and taking into account the instructions for the drugs, it is better to use ambrobene for the youngest patients, including infants.

As for the price, let's do a little calculation. For a course of cough treatment with normal viral infection You will need about 20 ambrobene tablets. The price for them is 150 rubles. ACC tablets 200 No. 20 cost about 300 rubles, this amount is also suitable for a course of treatment.

So, we see that ACC treatment will cost twice as much. What is better to choose is up to the doctor and the patient to decide.

ACC or fluimucil - which works better?

The means under consideration are structural analogues, which means that their operating principle is the same. After taking both medications, cough productivity noticeably improves by the end of the first day of use, and after a few days this symptom itself recedes due to the release of sputum and cleansing of the bronchopulmonary tree.

The companies and countries of manufacture of the drugs are different. Some people prefer products from Switzerland or Italy (fluimucil), while others prefer products from Slovenia and Germany (ACC).

If anywhere you can find significant differences in the presented products, then these are the forms of release. These funds have various variations not only in release form, but also in dosage, which makes it possible to use the medicine at any age. It should be noted right away that according to these criteria, ACC has an advantage.

For example, ACC has a syrup, but Fluimucil does not have this form. But fluimucil has a solution for oral administration, inhalation and injection (ACC does not have such forms). More details about all doses and forms are written in official instructions, where you can more clearly familiarize yourself with the information of interest.

Pulmonologists consider the undoubted advantage of fluimucil to be the use of a product for inhalation and injection, due to which acetylcysteine ​​gets to its destination faster. This speed of action of the drug is especially important in acute cases of the disease.

Popular in children's practice more syrups, so it’s better to recommend ACC in cherry-flavored syrup for kids. But anyway the right drug Only a pediatrician selects for children.

Parents must ensure that their child takes the syrup correctly. It is also important to give patients an alkaline drink to enhance the effect of ACC or fluimucil.

Comparing prices, it was noticed that the cheapest would be fluimucil in the form of effervescent tablets at a dose of 600 mg (about 150 rubles for 10 pieces). The price of ACC for the same dose and number of tablets is much more expensive, amounting to about 400 rubles. The cost of other forms is not particularly different; fluimucil is literally 10% cheaper.

Bromhexine or ACC?

The drugs are analogues only in their therapeutic effect. The active ingredient bromhexine repeats its name; the drug is classified as a stimulant of motor function of the respiratory tract and a secretolytic.

As well as ACC bromhexine affects the secretion of secretions by the bronchial glands, due to which thick sputum is liquefied. Under the influence of the agents under consideration, the secretion of sputum and its evacuation from the bronchi improves.

The toxicity of ACC is lower, so the list of contraindications is shorter. Bromhexine perfectly suppresses the cough center, and ACC acts on the peripheral cough mechanism. This feature of these drugs allows them to be prescribed in a complex manner, and the effect of treatment is much better than a single dose. The drugs complement each other perfectly.

Despite this possibility, this is not a reason to immediately take ACC and bromhexine together. It all depends on the clinic inflammatory process and the ability of the bronchi to self-cleanse.

All forms of bromhexine are lower in cost, for example, the price of its 100 ml syrup is 100 rubles cheaper than the same syrup from ACC.

ACC or Ascoril?

When comparing these drugs, let us note that ACC is a mono drug (the active component is acetylcysteine), and Ascoril is a combined drug that contains three active substances: bromhexine, guaifenesin and salbutamol.

Even to an ordinary person, without medical education, it will be clear that ascoril has a more powerful effect, because equipped with three medicinal substances. In addition to the mucolytic and expectorant effect, ascoril also has bronchodilator properties (relieves spasm of bronchial smooth muscles). Simply put, it relieves the feeling of tightness in the chest (suffocation).

If you look at the offers of pharmacies, then in most cases Askoril and ACC will be almost the same in price. For example, the price for a 200 ml bottle of syrup is approximately 400 rubles for both drugs.

The cardinal difference between the drugs under consideration is that Ascoril is not used for coughs that are not accompanied by obstruction and attacks of suffocation.

ACC and its analogues help against both dry and wet coughs, and choose a substitute according to active substance or suitable drug The therapeutic effect is up to the doctor to decide. Particularly unacceptable self-appointment medications such as Ascoril, which contains an active substance (salbutamol) that dilates the bronchi.

Do not select analogues at your own peril and risk, approaching the choice based only on price; cheaper does not mean more effective! A competent appointment is a chance for quick healing! Be healthy!

And a little about secrets.

If you or your child are often sick and are treated with antibiotics alone, know that you are only treating the effect, not the cause.

So you simply “spare” money to pharmacies and pharmaceutical companies and get sick more often.

STOP! Stop feeding someone you don't know. You just need to boost your immunity and you will forget what it’s like to be sick!

With the rest it is possible.

Not toka mona, dade noona! (With)

there you need a 2-hour break with antibiotics, that is, there is a difference in dosage, because acetylcysteine ​​can destroy the antibiotic.

it is both possible and necessary if the doctor has prescribed it.

I can add that it is better to drink ACC Long 600 mg according to the scheme: 300 in the morning + 300 in the evening, each time dissolving in a glass of water. In the evening, take no later than 20:00, an hour before take “Cough tablets” (dissolve 2 tablets in half a glass of water). Why not later? so that the cough does not torment you at night. And be sure to drink plenty of fluids so that the ACC has something to thin your phlegm. During treatment, you should not take medications containing Codeine.

ACC is a sputum thinner that must be used with antibiotics for pneumonia and bronchitis.

Granules in sachets of 100 or 200 mg, effervescent tablets 600 mg

ACC® 100 - one sachet contains 100 mg of acetylcysteine ​​in the form of granules for preparing a solution for oral administration(20 sachets per package). One sachet contains 2.9 g of sucrose.

ACC® 200 - one sachet contains 200 mg of acetylcysteine ​​in the form of granules for the preparation of a solution for oral use (20 sachets per package). One sachet contains 2.8 g of sucrose

ACC® LONG - one effervescent tablet contains 600 mg of acetylcysteine ​​(10 tablets per package).

Registration certificate No. 2132, 2293

pharmachologic effect

ACC® is a mucolytic expectorant used to thin sputum in diseases respiratory system, which are accompanied by education thick mucus. Due to the presence of a free sulfhydryl group, acetylcysteine ​​loosens disulfide bonds in sputum, which leads to depolymerization of mucopolysaccharides and helps reduce the viscosity of bronchial secretions. The drug facilitates the production of sputum.

ACC® also has antioxidant pneumoprotective properties, providing effective protection respiratory organs from toxic influence negative factors environment, tobacco smoke, supports functional activity and morphological integrity of lung tissue. In addition, ACC® helps increase the synthesis of glutathione, which is an important factor in chemical detoxification. This feature of acetylcysteine ​​makes it possible to effectively use the latter in acute poisoning paracetamol and others toxic substances(aldehydes, phenols, etc.).

Indications for use

The drug is used to treat acute and chronic pathology bronchopulmonary system, accompanied by increased sputum production and worsening expectoration: treatment of acute and chronic bronchitis, bronchiectasis, chronic obstructive bronchitis, bronchial asthma, as well as cystic fibrosis, tracheitis, laryngitis, sinusitis, inflammation of the middle ear with effusions.

Contraindications for use

The drug ACC® is not recommended to be taken if you have hypersensitivity to acetylcysteine ​​or its other components. In newborns, ACC® can be used only for health reasons under strict medical supervision.

What you need to know if you are pregnant or breastfeeding

Animal studies (rats, rabbits) indicate the absence of teratogenic effects of ACC®. To date, there are not enough observations of the use of acetylcysteine ​​during pregnancy and breastfeeding, and therefore taking the drug during this period is possible only as prescribed by a doctor.

Interactions with other drugs

Antibiotics

Tetracycline antibiotics (with the exception of doxycycline) are not recommended to be taken simultaneously with ACC®. Cases of inactivation of antibiotics by acetylcysteine ​​were observed exclusively during in vitro experiments with direct mixing of the latter. But for the safety of the patient oral administration antibiotics should not be combined with acetylcysteine ​​and possibly with an interval of at least 2 hours. In vitro incompatibility was observed with semisynthetic penicillins, tetracyclines, cephalosporins, and aminoglycosides. There is no evidence of incompatibility with antibiotics such as amoxicillin, erythromycin and cefuroxime.

Antitussives

At simultaneous use ACC® with other antitussives due to a decrease in the cough reflex, dangerous stagnation of mucus is possible.

Nitroglycerine

The simultaneous use of nitroglycerin and ACC® may lead to an increase in the vasodilating effect of nitroglycerin.

Dosage regimen

Adults and children over 14 years of age can use ACC® at a dose of 400–600 mg of acetylcysteine ​​per day.

Children from 2 to 6 years old - 200–300 mg of acetylcysteine ​​per day.

For newborns, starting from the tenth day of life and children under 2 years of age, it is recommended to use ACC® at a dose of 50 mg of acetylcysteine ​​2-3 times a day up to 100-150 mg per day.

Cystic fibrosis

For patients with cystic fibrosis and a body weight of more than 30 kg, the daily dose may be increased to 800 mg of acetylcysteine.

Children over 6 years old take ACC® 3 times a day, 200 mg (600 mg acetylcysteine).

For newborns, starting from the tenth day of life and children under 2 years of age, it is recommended to use ACC® at a dose of 50 mg of acetylcysteine ​​2-3 times a day (150 mg per day).

ACC® is recommended for use after meals. To do this, dissolve the composition of the sachet or tablet in 1/2 glass of water, juice or iced tea and drink the solution. Additional fluid intake enhances the mucolytic effect of the drug.

For acute uncomplicated diseases, ACC® is used for no more than 5–7 days. The duration of treatment for long-term diseases is determined separately. Treatment chronic diseases carried out for a long time or in courses of several months (up to 6 months).

Side effects

In some cases, diarrhea, nausea, heartburn and vomiting may occur. In rare cases, headaches and inflammation of the mucous membrane may occur. oral cavity and tinnitus. There are isolated reports of the occurrence of using ACC® allergic reactions, decreased blood pressure, bronchospasm (in patients with hypersensitivity bronchial system, for example, with bronchial asthma), quickly disappearing skin rashes, skin itching, tachycardia.

At the first signs of hypersensitivity to ACC®, you should stop using it.

Overdose and other application errors

To date, no severe or life-threatening cases have been observed. side effects and signs of overdose, even in extreme overdose conditions.

Safety Information

Acute toxicity

A study of the acute toxicity of acetylcysteine ​​was carried out on people receiving the highest daily dose of ACC® (up to 30 g of acetylcysteine ​​per day). There were no signs of intoxication in all cases of ACC® use.

Chronic toxicity

Experimental studies on animals (rats, dogs) indicate that long-term (up to 1 year) application of ACC® does not cause any pathological changes.

Neoplastic and mutagenic potential

Exists sufficient quantity studies that ACC® does not have a mutagenic effect on the body. The new educational potential has not been studied.

Study of reproduction

Teratogenicity studies were carried out on pregnant rabbits and rats during the period of organogenesis. The dose of the drug ranged from 250–500 and 700 mg/g in rabbits and about 500–1000 and 2000 mg/kg in rats.

There were no cases of deformities observed. The results of the study indicate the absence of negative effects on gonadal function, fertility and neonatal development.

Manufacturer

Hexal AG, Germany

Material provided by the representative office of Hexal AG in Ukraine,

Kyiv, st. Pushkinskaya, 12-A, off. 16. tel.:, fax:

Current information about prevention, tactics and treatment →

Review of existing options for prostate adenoma.

Taking ACC with antibiotics

Detailed information about the ACC is here.

Therapeutic effect

The active substance of the drug is acetylcysteine. It belongs to mucolytics, that is, to agents that are capable of thinning thick, viscous, difficult to separate sputum.

It is prescribed for respiratory diseases that are accompanied by cough:

• Pneumonia
• Bronchitis in acute and chronic form, as well as accompanied by obstruction
• Bronchial asthma
• Formation of purulent foci in the lungs
• Tracheitis
• Simultaneous inflammation of the larynx and trachea (laryngotracheitis)
• Bronchiectasis
• Cystic fibrosis
• Bronchiolitis.

In addition, the medication is prescribed for otitis media and rhinosinusitis, occurring in acute and chronic forms.

Acetylcysteine ​​is not an antibiotic; it is a derivative of the nonessential amino acid cysteine. Once in the body, it has direct action on rheological properties sputum and thereby facilitates its discharge. This therapeutic effect The medicine is based on the chemical reactions that occur in the body when it is taken. The acetylcysteine ​​molecule contains a free sulfhydryl or thiol group, which can break disulfide bridges (covalent bonds between 2 sulfur atoms) of acidic glycosaminoglycans, as a result of which sputum mucoids are depolarized and its viscosity decreases.

Due to the presence of a reactive thiol group, acetylcysteine ​​has antioxidant effects; in the body it binds to molecules free radicals and neutralizes them.

Acetylcysteine ​​is also involved in the production of glutathione, which is an antioxidant and promotes detoxification of the body.

If you drink ACC for prophylactic purposes in case of cystic fibrosis and chronic bronchitis of a bacterial nature, then these diseases are less likely to worsen and are easier.

When taken orally, acetylcysteine ​​is well absorbed. Passing the hepatic barrier, it is quickly metabolized into the active metabolite cysteine. The medication is excreted from the body through urine; the half-life is about an hour. But if the patient has liver pathologies, this time is extended to 8 hours.

Respiratory diseases accompanied by cough often have bacterial nature. Acetylcysteine ​​is not able to suppress pathogenic microflora, that is, it cannot remove the cause of the infection. For this purpose, antibiotics are prescribed at the same time. Antimicrobials for bacterial infection must be taken, otherwise you can start the disease, which will lead to severe complications. But in order for the therapy to have an effect, you need to know the compatibility of ACC with certain drugs.

Drug interactions

Before taking ACC, powder, tablets and syrup must be dissolved in water. It is not recommended to dilute acetylcysteine ​​with any medications, including antibiotics, in the same glass. Also, you should not mix injection drugs in one syringe. ACC form with other medications.

In laboratory experiments conducted outside human body When acetylcysteine ​​and antibiotics were simultaneously mixed in a test tube, the incompatibility of ACC with the following antibiotics was proven:

• Semi-synthetic penicillins, with the exception of amoxicillin, which may be marketed under such trade names like Amosin, Flemoxin Solutab, Ecobol
• Tetracycline series, except doxycycline, which is active substance drugs Unidox Solutab, Vibramycin
• Aminoglycosides, which include Gentamicin, Kanamycin, Streptomycin, Neomycin, Tobramycin, Amikacin
• Cephalosporins, with the exception of loracarbef and cefuroxime, the latter is known under the trade names Zinnat, Ceftin, Zinacef
• Amphotericin B.

When ACC was mixed in a test tube with these antibiotics, they reacted chemically with the sulfhydryl group of acetylcysteine, resulting in a decrease in the therapeutic effect of both medications.

Although drug interactions was noted only in vitro, it cannot be ruled out that such chemical reaction in the human body, and this in turn can reduce the effect of treatment, lead to the progression of infection and the development of severe complications.

Therefore, after taking ACC, these antibiotics can be taken no earlier than 2 hours later. If liver diseases are observed, this time should be increased, since in such patients acetylcysteine ​​is removed from the body longer.

Also, this interval must be maintained when prescribing injectable forms of antibiotics and ACC.

In laboratory experiments, inactivation of erythromycin and thiamphenicol was not observed.

There is even a ready-made one for sale. dosage form, which contains both acetylcysteine ​​and thiamphenicol, is produced under the trade name Fluimucil-antibiotic IT. This medication is a partial analogue of the drug ACC. In addition to the mucolytic effect, Fluimucil-antibiotic IT exhibits antibacterial activity against staphylococci, Haemophilus influenzae, streptococcus, which causes pneumonia, Klebsiella, Neisseria and some anaerobes. Like any antibiotic, the medication is available with a prescription.

Is it possible to take ACC and one or another antibiotic together? It is better to check with your doctor. Since the same drug can be found on sale under different trade names, a person far from medicine can easily get confused by them.

You also need to remember that ACC cannot be taken simultaneously with antitussives; they suppress the cough reflex, and this leads to sputum stagnating in the lungs. Therapeutic effect from acetylcysteine ​​is reduced when taken with activated carbon.

Can ACC and antibiotics be taken together?

Is it possible to take ACC and antibiotics at the same time?

ACC (Acetylcysteine) can be taken with antibiotics, but not together, not at the same time, there should be a two-hour break between doses. During treatment, you must first take ACC, followed by an antibiotic two hours later.

ACC penetrates the mucous membrane of the bronchial tree, the action of the drug allows antibiotics to more easily penetrate the sites of inflammation. ACC increases the effectiveness of antibiotic treatment.

If the doctor prescribed ACC and an antibiotic, then you should only take the antibiotic that was prescribed; you should not change the treatment regimen yourself.

Yes, ACC and antibiotics can be taken in parallel, but not at the same time. If we're talking about about any pulmonary infection, then such therapy is quite rational. Antibiotics fight the pathogen. At the same time, thanks to ACC, phlegm comes out of the lungs, and the person’s cough disappears.

However, if it is likely that acetylcysteine ​​will weaken the effect of some antibiotics: tetracyclines (except doxycycline), cephalosporins, semisynthetic penicillins, some aminoglycosides. Therefore, it is worth distinguishing between the use of the first and second. You should drink ACC in the morning, and if you choose ACC Long, which contains the daily dose of acetylcysteine, you can only drink one tablet/package per day. And after two hours you can start taking the antibiotic if it belongs to the specified groups.

I took it at the same time because the doctor prescribed an antibiotic, but didn’t prescribe anything for the cough, so I had to self-medicate.

It was only in this matter that I learned that this cannot be done.

At simultaneous administration ACC and azithromycin, the antibiotic still acts, perhaps not in the same way as it would have acted if the administration of these drugs was spaced out over time. You recover quickly, but the cough does not go away completely, ACC has a period of use that should not be exceeded, so after you stop taking ACC, it remains small residual cough and have to be treated with medicinal herbs. Still, it turns out that ACC and antibiotic are not the best and most effective combination.

ACC can be taken in combination with antibiotics only as prescribed by a doctor and a break of at least 2 hours must be taken between taking medications. Because if you take them at the same time, ACC may weaken the effect of the antibiotics and the treatment will not have the desired effect.

It is better not to take antibiotics without permission, since you do not know about the compatibility of these drugs with other drugs. Especially if you take any medications on an ongoing basis.

You can use the drug ACC in complex therapy with antibiotics, if the doctor prescribed these same antibiotics. Of course, you need a break between medications of at least 15 minutes, but about an hour is better. ACC and antibiotics are completely different drugs and do not replace each other or interfere with each other.

For what purpose should you self-medicate, it’s very in vain, since you won’t be able to diagnose yourself, and the doctor will be able to listen to you in order to prescribe the correct treatment.

Compatibility of ACC with antibiotics

I hope that I will find more valuable answers to this question on the Internet than the smart guys wrote here.

Amoxiclav is amoxicillin plus clavulanic acid.

And AMBROXOL or AMBROBENE 1 t / 3 r. per day for 5 days.

PLUS you need to drink plenty of fluids.

Every winter it gets worse (working outside).

This is the only way we can be saved. Improvements are noticeable the very next day.

Compatibility of ACC with antibiotics

Consultations are provided by specialists and scientists with higher pharmaceutical education. The section “Question to a pharmacist, pharmacist” is ISSF WebApteka.RU’s own independent consulting section. We guarantee the independence of our answers from the financial interests of specific manufacturers of medicines, dietary supplements, distributors and other similar organizations.

We kindly ask you: before asking a question, check whether other users have asked it before ( use keyword search among already existing questions and answers).

Omez is used 30 minutes before meals.

Ferrum lek - during or immediately after meals.

ACC - immediately after eating.

Taking trichopolum and karsil does not depend on food intake.

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Pneumonia, antibiotics and ACC

I took all this for 2 days. And suddenly I read in the instructions for ACC - it is pharmacologically incompatible with such and such antibiotics, incl. with cephalosporins. Reduces the absorption of antibiotics such and such, incl. cephalosporins.

Now I’m thinking, is it possible to combine it and if I replace the ACC, then with what?

I went to work today (I was called) and I regret it, I was only at home for 3 days.

did you do physical therapy, IVs, massage?

When I lie down in the evening with a book, sleep at night, and until I get up in the morning, I hardly cough. During the day on work-from-work, take the child, pick him up, go there, cook something to eat - I’m coughing.

Does this mean that you need to lie down more or, on the contrary, you need to cough to get rid of phlegm? (and coughing is not always productive). What else can you do to get well faster? Massage? Physio? The doctor didn’t prescribe anything else, maybe I should have asked for it myself?

In general, with this disease they suggest going to a hospital, if not, then at home, on bed rest. Well, if, of course, you want to be cured and then have no relapses every year.

My husband is on a business trip, so I have to do everything myself. Bed rest at home still doesn't work. And they offered me a hospital stay, but I had no one to leave the children with.

My boss called me to work yesterday. True, today he is already looking sideways at me and asking if it’s contagious and if he should let me go back.

Z.y. By the way, pneumonia can be easily treated with antibiotic tablets.

I go to in vitro to get injections, first thing in the morning, on the way to work, 5 minutes before opening, in the evening there is no one there at all, picking up the child I go in for an injection.

Why do you go to work? Well, it’s like there’s a crisis right now, I definitely won’t find a job like this again, they often meet me halfway - a layoff slave. day, convenient schedule - the same is expected of me. Life is like that)

From physio-electrophoresis with aminophylline and inhalation of Berodual and Fluimucil.

and so on for the future - I didn’t listen to you, I don’t know the medical history - but you don’t indicate the temperature and I suspect the character of the blood has not changed much. All this points (including autumn) to pneumonia of an atypical nature, and the choice of AB here is very important. What I mean is, if in the period after 7 days after the end of ceftriaxone the cough continues to bother you, and the picture on the x-ray does not change, you definitely need to look towards sumamed.

But I didn’t go to work today. It turned out that my boss, who urgently called me to work, did not know what pneumonia was, and when he found out that it was pneumonia and that you could get infected, he was not happy.

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Compatibility of ACC with antibiotics

Granules for the preparation of solution for oral administration white, homogeneous, without agglomerates and mechanical impurities, with the smell of lemon and honey; When sifting through a 1.5 mm sieve, no particles should remain on the sieve.

Excipients: sucrose, ascorbic acid- 75 mg, sodium saccharinate - 20 mg, lemon flavoring mg, honey flavoring mg.

3 g - bags made of three-layer material (6) - cardboard packs.

Mucolytic drug. Acetylcysteine ​​is a derivative of the amino acid cysteine. It has a mucolytic effect, facilitates the discharge of sputum due to a direct effect on the rheological properties of sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.

In addition, acetylcysteine ​​promotes the synthesis of glutathione, important component antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

At prophylactic use acetylcysteine ​​there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Suction and distribution

Absorption is high. Bioavailability when taken orally is 10%, which is due to the pronounced “first pass” effect through the liver. The time to reach Cmax in blood plasma is 1-3 hours.

Binding to blood plasma proteins - 50%. Penetrates through the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the BBB and be excreted in breast milk.

Metabolism and excretion

Rapidly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.

Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T 1/2 is about 1 hour.

Pharmacokinetics in special clinical situations

Impaired liver function leads to an extension of T1/2 to 8 hours.

Respiratory diseases accompanied by the formation of viscous, difficult to separate sputum (acute and chronic bronchitis, obstructive bronchitis, tracheitis, laryngotracheitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, bronchiolitis, cystic fibrosis);

Acute and chronic sinusitis;

Granules for the preparation of solution for oral administration (orange) 100 mg and 200 mg, g ranula for preparation of solution for oral administration 200 mg

At cystic fibrosis Children over 6 years of age are recommended to take the drug 200 mg 3 times a day. Daily dose mg.

Children aged 2 to 5 years - 100 mg 4 times a day. Daily dose mg.

For patients weighing more than 30 kg with cystic fibrosis, the dose can be increased to 800 mg/day if necessary.

At

ACC ® in the form of granules for oral solution (orange) 100 mg and 200 mg dissolved in water, juice or iced tea.

ACC ® in the form of granules for the preparation of a solution for oral administration, 200 mg, is dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Granules for solution for oral administration 600 mg

At short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used for a longer period of time to prevent infections. For long-term illnesses, the duration of therapy is determined by the attending physician.

The drug is taken orally after meals. Additional fluid intake enhances the mucolytic effect of the drug.

The granules are dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Adults and adolescents over 14 years of age are prescribed 10 ml of syrup 2-3 times a day (mg acetylcysteine).

Children aged 6 to 14 years - 5 ml of syrup 3 times a day or 10 ml of syrup 2 times a day (mg acetylcysteine).

Children aged 2 to 5 years are prescribed 5 ml of syrup 2-3 times a day (mg acetylcysteine).

At cystic fibrosis Children over 6 years of age are recommended to take 10 ml of syrup 3 times a day (600 mg acetylcysteine); children aged 2 to 5 years - 5 ml of syrup 4 times a day (400 mg acetylcysteine).

At short-term colds Duration of treatment is 4-5 days. At chronic bronchitis and cystic fibrosis the drug should be used for a longer period of time to prevent infections. For long-term illnesses, the duration of therapy is determined by the attending physician.

The drug is taken orally after meals. Additional fluid intake enhances the mucolytic effect of the drug.

ACC ® syrup is taken using a measuring syringe or measuring cup contained in the package. 10 ml ACC syrup® corresponds to 1/2 measuring cup or 2 filled syringes.

Using a measuring syringe

1. Open the bottle cap by pressing on it and turning it counterclockwise.

2. Remove the cap with the hole from the syringe, insert it into the neck of the bottle and press in until it stops. The stopper is designed to connect the syringe to the bottle and remains in the neck of the bottle.

3. It is necessary to insert the syringe tightly into the stopper. Carefully turn the bottle upside down, pull the syringe plunger down and draw required amount syrup (ml). If air bubbles are visible in the syrup, press the plunger all the way and then refill the syringe. Then return the bottle to its original position and remove the syringe.

4. The syrup from the syringe should be poured onto a spoon or directly into the child’s mouth (into the cheek area, slowly, so that the child can swallow the syrup). While taking the syrup, the child should be in an upright position.

5. After use, rinse the syringe with clean water.

According to WHO unwanted effects classified according to their frequency of development in the following way: very often (≥1/10), often (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000) и очень редко (<10 000), частота неизвестна (частоту возникновения нельзя определить на основании имеющихся данных).

Allergic reactions: uncommon - skin itching, rash, exanthema, urticaria, angioedema; very rarely - anaphylactic reactions up to shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the cardiovascular system: infrequently - decreased blood pressure, tachycardia.

From the digestive system: uncommon - stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

On the part of the hearing organ: infrequently - tinnitus.

Others: rarely - headache, fever; in isolated cases - the development of bleeding as a manifestation of a hypersensitivity reaction, a decrease in platelet aggregation.

Peptic ulcer of the stomach and duodenum in the acute phase;

Lactation period (breastfeeding);

Children under 2 years of age (syrup, granules for oral solution /orange/ 100 mg and 200 mg);

Children under 6 years of age (granules for solution for oral administration 200 mg);

Children under 14 years of age (granules for oral solution 600 mg);

Fructose intolerance, because the drug contains sorbitol (granules for the preparation of an oral solution /orange/ 100 mg and 200 mg, granules for the preparation of an oral solution 200 mg and 600 mg);

Sucrase/isomaltase deficiency, glucose-galactose deficiency (granules for oral solution /orange/ 100 mg and 200 mg, granules for oral solution 200 mg and 600 mg);

Hypersensitivity to acetylcysteine ​​and other components of the drug.

WITH caution the drug should be used in patients with a history of gastric and duodenal ulcers; for bronchial asthma, obstructive bronchitis; liver and/or kidney failure; histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; diseases of the adrenal glands; arterial hypertension.

Due to insufficient data, the use of the drug during pregnancy is contraindicated.

For syrup: use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Contraindications: children under 2 years of age (the drug is in the form of syrup and granules for the preparation of an oral solution / orange / 100 mg and 200 mg); children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration, 200 mg); children under 14 years of age (the drug is in the form of granules for the preparation of an oral solution 600 mg).

The choice of release form and dosage regimen is carried out taking into account the age of the patient.

For bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

Severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes in the skin and mucous membranes occur, the patient should immediately stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime (the preferred time of administration is before 18.00).

When prescribing the drug to patients on a diet aimed at limiting sodium intake, it is necessary to take into account that 1 ml of ACC ® syrup contains 41.02 mg of sodium.

There is no need for special precautions when disposing of unused ACC ® .

Instructions for patients with diabetes mellitus

When treating patients with diabetes mellitus, it is necessary to take into account that ACC ® in the form of granules for the preparation of oral solution (200 mg, 600 mg, orange 100 mg and 200 mg) contains sucrose.

ACC ® in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg: 1 sachet of 100 mg corresponds to 0.24 XE, 1 sachet of 200 mg - 0.23 XE.

ACC ® in the form of granules for the preparation of a solution for oral administration 200 mg: 1 sachet corresponds to 0.21 XE.

ACC ® in the form of granules for the preparation of a solution for oral administration 600 mg: 1 sachet corresponds to 0.17 XE.

Impact on the ability to drive vehicles and operate machinery

There is no information on the effect of the drug on the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Acetylcysteine ​​when taken at a dose of 500 mg/kg/day does not cause signs and symptoms of overdose.

Symptoms: In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn, and nausea are observed.

Treatment: carrying out symptomatic therapy.

With the simultaneous use of acetylcysteine ​​and antitussives, sputum stagnation may occur due to suppression of the cough reflex.

With the simultaneous use of acetylcysteine ​​and oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), the latter may interact with the thiol group of acetylcysteine, which can lead to a decrease in antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbef).

Concomitant use with vasodilators and nitroglycerin may lead to an enhanced vasodilator effect.

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

The shelf life of granules for the preparation of oral solution (200 mg, 600 mg) is 3 years.

The shelf life of granules for preparing a solution for oral administration (orange) is 4 years.

The shelf life of the syrup is 2 years; Once opened, the bottle should be stored for no more than 18 days at a temperature not exceeding 25°C.

The drug is approved for use as a means of OTC.

The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

There are contraindications, consult your doctor.

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Why we cough, how the lungs are like trees, what bronchiolitis is and whether ACC will help overcome a cough, read in the issue of the section “How we are treated.”

With the first snow and cold weather, the country is hit by a wave of acute respiratory viral diseases. This may be why, last October, the cough medicine ACC immediately jumped nine positions up in the list of the analytical company DSM Group, becoming one of the ten most popular drugs (by sales value). But this, as we have seen more than once, does not at all guarantee its effectiveness. What does science say about this drug?

Why do you need a cough?

Human respiratory systems

Wikimedia Commons

A wet cough removes mucus from the lungs with accumulated bacteria or viruses and cells of one’s own immune system that have fallen on the “battlefield” (and in severe cases, pus or even blood) - the so-called sputum. By its transparency, thickness and color, the doctor can judge what a person is sick with, suspect the patient has purulent processes in the lungs, tuberculosis, pneumonia and other diseases in order to send for further examination. Therefore, when answering the doctor’s questions about your complaints, you need to pay attention to some of its unusual properties. A rusty tint can indicate dangerous pneumonia - lobar pneumonia (due to the breakdown of red blood cells). Spitting blood may indicate tuberculosis or pulmonary vascular lesions, purulent sputum may be a sign of purulent bronchitis or a lung abscess, and so on.

You can read where mucus comes from in the lungs in the review. In short, it is needed to prevent the cells of the lungs from sticking together when we exhale air. In addition, mucus helps gas exchange in the lungs, which allows us to absorb more oxygen. But with diseases of the respiratory tract, it becomes a breeding ground for microorganisms and accumulates dead cells, and even performs its usual work worse, so the body tries to get rid of it (especially since new ones are being produced more or less constantly). To do this, they try to convert a dry cough into a wet one.

From what, from what?

ACC is available in the form of syrup, soluble tablets and granules for preparing a hot drink. The name ACC itself is an abbreviation for the name of the active substance, acetylcysteine. It may seem familiar to you if you have heard of cysteine ​​- after all, in essence, it is a derivative of the amino acid cysteine. But, unlike amino acids, the body does not use acetylcysteine ​​to build proteins, but rather converts it in several stages into a substance called glutathione. It is an antioxidant involved in many processes in the body.

Model of the acetylcysteine ​​molecule

Fvasconcellos/Wikimedia Commons

Glutathione can bind to the substance into which paracetamol is converted in the body, neutralizing its harmful effect on liver enzymes, so do not be surprised if you are offered to drink acetylcysteine ​​in case of an overdose of this drug. True, it is not entirely clear how best to use it in this case - intravenously or simply orally.

Glutathione molecule model

Ben Mills Wikimedia Commons

Another popular use of drugs with acetylcysteine ​​is the fight against too viscous and poorly separated sputum, pulmonary obstruction (as an additional remedy), pulmonary complications after surgery on the heart or lungs, lung collapse (when it “sticks together”) and for various injuries of this organ . It is also used during operations on the trachea and bronchi.

They also sometimes try to use acetylcysteine ​​against cystic fibrosis (a severe genetic disease in which the functioning of the exocrine glands and respiratory organs is impaired), but it does not make sense to widely recommend such treatment, according to a review of scientific articles conducted by specialists from the Cochrane Collaboration, because there is too much reliable evidence few.

Also, in a test tube, acetylcysteine ​​can kill bacteria by destroying their associations - biofilms, which made them practically invulnerable to drugs. This was demonstrated by the authors of a 2011 scientific article. It is possible, by the way, that the mechanism here is similar to the one that helps the separation of viscous sputum: both mucus in the lungs and biofilms contain polysaccharides - long carbohydrate chain molecules. It is believed that acetylcysteine ​​breaks the bonds between them.

In a 2010 study, German doctors also proved that in vitro(“in vitro”) acetylcysteine ​​also suppresses the reproduction of influenza A viruses. If the antiviral effect also works in patients, it (as well as the effect on the properties of mucus) can additionally help ACC fight respiratory diseases. Let's see if he does this in public.

Not on the lists

The drug ACC was patented in 1968. Over the years of use around the world, many results from clinical trials of the drug and patient observations have accumulated. Indeed, several Cochrane reviews are devoted to the use of this drug for diseases of the respiratory system.

The Cochrane Library is a database of the international non-profit organization Cochrane Collaboration, which participates in the development of guidelines of the World Health Organization. The organization's name comes from its founder, the 20th-century Scottish medical scientist Archibald Cochrane, who championed the need for evidence-based medicine and good clinical trials and wrote the book Efficiency and Effectiveness: Random Reflections on Health Care. Medical scientists and pharmacists consider the Cochrane Database to be one of the most authoritative sources of such information: the publications included in it have been selected according to the standards of evidence-based medicine and report the results of randomized, double-blind, placebo-controlled clinical trials.

The first review was written in 2004 and summarized information from 33 scientific articles that used various agents for lung injury and acute respiratory distress syndrome, but acetylcysteine ​​did not show any activity.

Several reviews concern the cystic fibrosis we have already mentioned. But the conclusions here are disappointing: the authors complain that there is very little reliable evidence. What does it mean? We are talking about randomized, double-blind, placebo-controlled studies: although the authors found about two dozen studies in total, only six met their criteria, and even then acetylcysteine ​​cannot be recommended on their basis.

A double-blind, randomized, placebo-controlled method is a method of clinical drug research in which the subjects are not privy to important details of the study. “Double blind” means that neither the subjects nor the experimenters know who is being treated with what, “randomized” means that the assignment to groups is random, and placebo is used to show that the effect of the drug is not based on self-hypnosis and that This medicine helps better than a tablet without active ingredients. This method prevents subjective distortion of the results. Sometimes the control group is given another drug with proven effectiveness, rather than a placebo, to show that the drug not only treats better than nothing, but is superior to its analogues.

Another review compares the effects of two drugs, acetylcysteine ​​and carbocysteine, against acute respiratory tract infections in children. The authors reviewed 34 scientific papers on drug safety and six scientific papers that examined the effectiveness of the drug. In general, acetylcysteine ​​appears to be safe for children over two years of age. The effectiveness of the drugs was limited - by the seventh day of treatment the cough was clearly reduced, but it was not entirely clear what role natural recovery played in this. The data on the use of acetylcysteine ​​for bronchiectasis (dilation of the bronchi when they are damaged) were also not the most convincing.

However, there are many clinical trials proving the benefits of acetylcysteine ​​in chronic bronchitis (but not bronchitis with complications). But inhalations with acetylcysteine ​​did not help against bronchitis. For pulmonary obstruction, numerous systematic reviews of randomized, double-blind comparative trials have shown that acetylcysteine ​​promotes mucus separation and prevents further complications.

The effectiveness of acetylcysteine, the active ingredient of the ACC drug, against dry cough has been confirmed by evidence-based medicine. Acetylcysteine ​​is also included in the list of essential drugs from the point of view of the World Health Organization as a specific antidote (antidote) that is used in case of paracetamol overdose. At the same time, ACC most likely will not help against cystic fibrosis, although it was included in federal recommendations for combating the symptoms of this disease. The same applies to lung injuries.

You need to understand that despite its effectiveness against cough, ACC itself is not always enough to cope with the infection that causes the disease. Therefore, in the case of pneumonia, for example, you will need antibiotics, and to combat other symptoms - pain, weakness, fever - antipyretic and painkillers may be useful. If you also have a stuffy nose, you may need cold medicine.

It is possible to choose the right combination of drugs and decide whether an antibiotic is needed only by making the correct diagnosis. Sometimes this requires a laboratory test (for example, to find certain bacteria), so it is better to visit a doctor.

Acetylcysteine ​​is prescribed in all cases of diseases with the accumulation of thick, viscous sputum in the bronchial tree and upper respiratory tract, namely:

Acute and chronic bronchitis, including obstructive;

Bronchiolitis;

Tracheitis;

Bronchial asthma;

Bronchiectasis;

Cystic fibrosis;

Laryngitis;

Sinusitis;

Exudative otitis media.

ACC pharmacological action

The active ingredient is acetylcysteine, a derivative of cysteine ​​(amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and increases the viscosity of bronchial secretions. As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (the detoxifying effect is possible due to increased production of glutathione).

Acetylcysteine, when used internally, is almost immediately completely absorbed from the gastrointestinal tract. The active metabolite is cysteine, which is formed in the liver. Further, the metabolism of acetylcysteine ​​passes through the formation of diacetylcysteine, cystine. The final product of metabolism is mixed disulfides.

Bioavailability is 10%. Cmax is determined after internal use after 1-3 hours. Plasma proteins bind 50% of acetylcysteine. The maximum concentration of the pharmacologically active metabolite in the blood is 2 µmol/l.

Inactive metabolites are excreted in the urine (inorganic sulfates, diacetylcysteine), but a small amount of acetylcysteine ​​is excreted in the feces unchanged.

The half-life of acetylcysteine ​​depends on biotransformation in the liver. In case of liver failure, it is 8 hours, whereas normally it is 1 hour. It passes through the hematoplacental barrier and can accumulate in the fetal fluid.

ACC dosage for use

The daily dose for the treatment of cystic fibrosis in patients weighing more than 30 kg is used up to 800 mg. Children from the 10th day of life to 2 years of age are given 50 mg 2-3 r/s. At the age of 2-5 years - 400 mg per day, divided into 4 doses. From 6 years – 600 mg/s (divided into 3 doses). Treatment is continued for a long time, in courses of several months (3-6).

In all other cases, the daily dose for children over 14 years of age and adults is 400-600 mg. From 6 to 14 years – 300-400 mg (divided into 2 doses), 2-5 years – 200-300 mg (divided into 2 doses). Children from the 10th day of life to 2 years of age are treated with 50 mg 2-3 r/s. For acute diseases without complications, the product is prescribed for 5-7 days. In case of complications or chronic course, a course of treatment is possible (up to 6 months).

ACC is taken after a meal. The tablet or contents of the sachet must be dissolved in half a glass of liquid (iced tea, water, juice).

ACC contraindications

Hypersensitivity to acetylcysteine ​​and excipients

Peptic ulcer

Hereditary fructose intolerance

Pulmonary hemorrhage or hemoptysis

In pediatric practice - for hepatitis and renal failure (threat of accumulation of nitrogen-containing products).

ACC side effects

From the gastrointestinal tract - stomatitis, nausea, vomiting, diarrhea, heartburn.

From the side of the central nervous system - headache, tinnitus.

From the cardiovascular system – arterial hypotension, increased heart rate.

Allergic reactions - bronchospasm (especially with bronchial hyperreactivity), rash and itching of the skin. Often the cause of hypersensitivity to the product is the presence of propyl and methyl parahydroxybenzoate in the composition.

ACC release form

ACC 100, 200 - effervescent tablets, 20 pcs.

ACC hot drink – powder for preparing a hot drink for internal use - 200 mg (20 sachets) and 600 mg (6 sachets).

ACC-long – effervescent tablets (600 mg), 10 pcs. in the tube.

ACC powder for the preparation of solution for oral administration – 100, 200 mg, 2 pcs. in a pack.

ACC for children - powder for preparing a solution for internal use, 30 g in a 75 ml bottle (20 mg/ml) and 60 g in a 150 ml bottle (20 mg/ml).

ACC composition

Effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sucrose, saccharin, flavoring).

Powder: acetylcysteine ​​and auxiliary components (sucrose).

ACC Long effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sodium citrate, saccharin, sodium cyclamate, lactose, citric acid, sodium carbonate, mannitol, sodium bicarbonate, flavoring).

ACC for children: acetylcysteine.

ACC during pregnancy

Acetylcysteine ​​has no embryotoxic effect, however, during pregnancy and breastfeeding it is prescribed only if indicated under the supervision of a physician.

ACC interaction with other drugs

Tetracycline and its derivatives (except doxycycline) cannot be used together with ACC in pediatrics.

During in vitro experimental studies, no cases of inactivation of other types of antibacterial products were identified. However, it is recommended to maintain a gap of at least 2 hours between taking the ACC and the antibiotic. In vitro, the incompatibility of acetylcysteine ​​with semisynthetic penicillins, aminoglycoside and cephalosporin antibiotics has been proven. Such studies have not been conducted with erythromycin, amoxicillin and cefuroxime.

The simultaneous use of antitussives can lead to stagnation of respiratory tract secretions.

Use with nitroglycerin may enhance the vasodilatory effect subsequently.

Medicine synonym for ACC

No data..

ACC additional information

ACC is used with caution for gastric or duodenal ulcers.

When preparing the solution, a patient with bronchial asthma may inhale air containing product particles, which causes irritation of the mucous membranes of the upper respiratory tract and can provoke reflex bronchospasm.

For a better mucolytic effect when treating with acetylcysteine, you should take plenty of fluids.

10 ml of ready-made oral solution contains 0.31 carbohydrate units, which should be taken into account by patients with diabetes mellitus.

Sorbitol has a slight laxative effect on stool.

In newborns and children under 1 year of age, acetylcysteine ​​is used exclusively for health reasons under strict medical supervision. The recommended dosage (10 mg/kg body weight) cannot be changed.

ACC 200 is not used for children under 2 years of age.

The speed of reaction when driving and working with machinery does not change when taking acetylcysteine.