Duphaston (France) effective hormonal agent Mainly used in gynecology. The drug has high cost, but on pharmaceutical market You can purchase duphaston analogues with identical active ingredients in their composition in terms of their therapeutic effect and at a lower cost.

Stops uterine bleeding and also significantly increases the chances of conception. Indications for use are: hormonal infertility, threat of miscarriage, menstrual irregularities, preconception preparation and pregnancy.

The medicine suppresses the production of estrogen, which is necessary to achieve positive therapeutic effect in the treatment of endometriosis. As a rule, the doctor individually selects the patient’s treatment regimen and dose of duphaston, which gives an excellent effect in therapy.

Duphaston composition and price

Active substance dydrogesterone the composition of the drug is similar to natural progesterone. The substance does not interfere with carbohydrate metabolism and liver function, and helps eliminate many gynecological pathologies.

• The cost of a package of 10 mg tablets, 20 pieces - 550 rubles, pack. 28 pcs. - 930 rub.

Duphaston analogues for therapeutic action

All medications presented in the list are similar to duphaston and contain steroid hormone progesterone.

1 . Utrozhestan (Bezen Healthcare SA, Belgium). Progestin agent - active ingredient contains a hormone corpus luteum. Creates the conditions necessary for pregnancy to occur. Relieves tension in the uterine muscles.

Prescribed for infertility, fibrocystic mastopathy, threatened miscarriage and uterine bleeding, delayed intrauterine development fetus As a rule, for patients with liver disease the drug is prescribed vaginally.

According to doctors, this analogue of duphaston is well tolerated and helps to increase the pregnancy rate of problematic pregnancies. Do not use if you are prone to thrombosis, severe violations liver function, vaginal bleeding, incomplete abortion, suspected malignant tumors.

• Cost of capsules 100 mg 28 pcs. - 410 rub., 14 pieces 200 ml - 420 rub.

2 . Prajeesan (Sun Pharmaceutical, India). Indications for use are: infertility, mastopathy, lack of ovulation, hormonal therapy associated with menopause, prevention of fibroids and endometriosis, vaginal bleeding unknown origin.

The medicine can be used during pregnancy, but the decision is made by the attending physician, taking into account the course of the disease and the patient’s condition, since in some cases there may be a risk to the fetus.

Contraindications to prim are: incomplete abortion, suspicion or presence malignant tumors, individual intolerance components of the drug and peanut oil, thromboembolic disorders, uterine bleeding.

• Price cap. 200 mg, 10 pieces - 260 rub.

3. Iprozhin (Italfarmaco, Italy). Used for gestogenic insufficiency. Reduces the tension of the uterine muscles, promotes the development of the terminal components of the mammary gland, creates conditions for proper development endometrium, normalizes menstrual cycle.

The drug is indicated for fibrocystic mastopathy, the threat of spontaneous abortion, and also as a therapeutic measure for menopause. Do not take if you are hypersensitive to any ingredient of the medication, bloody discharge of unknown nature, incomplete abortion.

At functional disorders liver is shown vaginal use. The product should be used with caution under the supervision of a physician during current pregnancy and breastfeeding.

• Pack of capsules 100 mg, 30 pcs. - 400 rub.

4 . Progesterone (Dalkhimpharm, Russia). It is an analogue of duphaston and is available in the form of an injection solution. Indications for use include: endocrine infertility, dysfunctional uterine bleeding, recurrent miscarriages, amenorrhea, contraception.

According to reviews from doctors and patients, the drug is characterized as highly effective and has significant amount positive feedback, but since the product contains olive oil at intramuscular injection The injections are somewhat painful. Prohibited for use in cases of functional liver disorders, hepatitis, bleeding, thrombosis.

• Solution 1%, 1 ml, 10 pcs. - 390 rub. or solution 2.5%, 1 ml, 10 pieces - 650 rubles.

The modern pharmacological market offers many various medications. Some of them are interchangeable, there are analogues and generics. If we are talking about a drug like Duphaston, then there are several analogues. It is only important to understand the basic principles of action of each drug and understand the difference.

Duphaston and its analogues

All analogues of Duphaston, like the original drug itself, contain synthetic progesterone, a hormone that is responsible for the course of pregnancy.

They are used for following states observed in women:

• menstrual irregularities;
• bleeding in the uterus;
• acute PMS;
• infertility, which occurs due to luteal insufficiency;
• endometriosis;
• menopause and menopausal syndrome;
• mastopathy of the mammary glands.

It is also often prescribed to pregnant women who are found to be at risk of miscarriage. Progesterone contributes to the normal course of pregnancy.

It creates conditions for normal education ovum, reliable attachment to the wall of the uterus, its nutrition, and also prevents miscarriages during the first trimester, when hormonal levels are still unstable. With a lack of progesterone, the body cannot react correctly to the appearance of the fetus, perceives it as a foreign object and rejects it. It is for this reason that frequent miscarriages occur during the first three months of pregnancy.

Duphaston and its analogues are as close as possible in their structure to hormones that naturally are produced by the female body, as a result of which progesterone is absorbed most efficiently when internal reception drug. The most important advantage of such funds is their origin. Unlike most synthetic hormones, the substances contained in the drug are not derivatives of testosterone, which eliminates the appearance of many side effects:

• liver dysfunction;
• blood clotting disorder;
• manifestation female characteristics in a male fetus;
• manifestation male characteristics in female fetuses;
• change in glucose concentration;
• negative impact on the internal secretion organs.

Duphaston has virtually no contraindications. The only reason why a drug can be excluded is individual intolerance to some components, that is, an allergy. In order to determine whether this remedy is suitable for treatment or not, it is necessary to undergo mandatory inspection and consult with experienced specialist. It has successfully proven itself in modern gynecology and is widely used for the treatment and prevention of many conditions.

Choosing the right product

Duphaston is an expensive drug that must be taken for long period time. Often, such expenses can become unaffordable for future parents. However, pharmacology offers many replacement options, since there are drugs on the market with similar composition or pharmacological action. So what can replace Duphaston and what criteria should you use when choosing?

The most important indicator when choosing an analogue, it is not the price (although it plays a big role), but the therapeutic effect of the product. Indications for use and the list of conditions for which the medicine is used should be as identical as possible. The products do not have to be completely identical when it comes to composition. Some drugs may have the same active ingredients, be similar to it, or differ completely in composition, but have an almost identical effect on the body. Therefore, all analogues can be divided into two main groups:

• identical;
• drugs with similar effects.

It is very important to understand that before changing the drug, you need to consult with your doctor, who will not only help you choose suitable remedy, but will also be able to guarantee its maximum effectiveness in each individual case. This is due to the characteristics of the organism to which different drugs can provide different action.

Identical composition

The composition and, therefore, all therapeutic characteristics of the two drugs are completely identical: Duphaston and Dydrogesterone. They can replace Duphaston without any harm to the body. However, despite the identical active ingredient, they have some differences, which you need to be aware of before taking each of the described remedies.

1. 1. Duphaston.

Duphaston is a generic drug known drug. As you know, the generic is completely identical medicine, which has a different name because the original was developed by another company that patented it. Duphaston was released differently pharmaceutical company, but its composition is completely identical to its predecessor. The only difference is the price, which can be either higher or lower, depending on the pharmacy chain, place of sale and country of manufacture.

1. 2. Dydrogesterone.

Dydrogesterone, in turn, has a slightly different composition, but has an absolutely identical effect. Its only component is the substance of the same name, which is also the main component of Duphaston - synthetic progesterone. The additional ingredients indicated in the composition are necessary only to create the dosage form and do not in any way affect the action of the medicine. Since production requires minimum costs, then the cost of Dydrogesterone is an order of magnitude lower than that of other products in this series. The main difficulty in its use is its relative rarity on sale. It is produced in limited quantities and rarely appears in pharmacies. This issue is especially acute for regional pharmacies in remote cities, as well as cities with small populations.

Similar action

The second group of drugs includes drugs that have a different composition, but have the same therapeutic characteristics and testimony that Duphaston. They can be used to treat the same diseases for which the original drug is intended, but they are also slightly different. To fully replace one drug with another, you need to consult a specialist.

1. 1. Utrozhestan.

The most popular and well-known analogue is a drug developed in Thailand, known as Utrozhestan. The main component is natural micronized progesterone. It was obtained with the participation of volunteers and also synthesized with the help of animals. Wide use it was obtained precisely because of the naturalness of the active substance, which practically does not cause allergic reactions, unlike artificially created hormone substitutes. Despite all the positive aspects, Utrozhestan has some negative side effects and has contraindications:

• often provokes headaches and migraines;
• may cause itching, hives, allergic reactions, up to Quincke's edema;
• causes increased fatigue, drowsiness and decreased performance;
• contraindicated for women who are engaged in active activities;
• it is prohibited for women who drive vehicles;
• prohibited for use by women who experience bleeding in the birth canal.

That is why the use of Utrozhestan should be agreed with a doctor and prescribed only after an examination and tests that exclude the possibility of manifestations negative consequences from consumption medicine. The most important test is to check for allergic reactions and intolerance to the components of the drug.

It is produced in two dosage forms: in the form of tablets, as well as suppositories, which are used intravaginally.

It is Utrozhestan that is considered the most a worthy replacement Duphaston.

It is most similar to natural hormones, which are produced in the female body, and promote pregnancy, and also fully prepare the endometrium, creating favorable conditions for egg implantation and successful pregnancy early stages. TO positive aspects This remedy can be attributed to the fact that it does not promote weight gain, does not retain fluid in the body, and does not affect blood pressure and metabolic processes.

1. 2. Progesterone.

A drug Russian production Progesterone has the same effect on female body, as Duphaston. Moreover, its main active ingredient is gestagen, which is also known as the corpus luteum hormone. The main difference between the two tools is dosage form. Duphaston is available in tablet form, Progesterone is available only in injection form. Most often it is used for inpatient treatment in hospitals, because independent use can be quite problematic. Its form also allows you to accelerate the effect of the drug on the body, which makes it indispensable in treatment severe forms spontaneous abortion.

The main reason for replacing Duphaston with any of its analogues is cost original drug. Almost all analogs have a price several times lower, which makes them accessible to everyone. Most often, the price is determined by the country of origin, the company that launched the product on the market, and also official representative and a network of pharmacies that sell and set their own price for the medicine.

Name:

Duphaston

Pharmacological
action:

Dydrogesterone, which is the active substance of duphaston, - progestogen, an analogue of natural progesterone. It has no estrogenic, androgenic or corticoid effect. Does not change thermogenesis, so the presence of ovulation can be determined by monitoring basal temperature bodies. Does not affect metabolism. There are no side effects associated with the use of synthetic progestins. Effective when used internally. Selectively affects progestin receptors of the uterine mucosa. Causes normal secretory transformations in the endometrium in case of sufficient estrogen saturation. Does not affect follicle ovulation. Does not have a virilizing and/or masculinizing effect (including on the fetus).

After oral administration quickly absorbed from gastrointestinal tract. The maximum concentration in the blood after administration is observed In 2 hours. 97% of dydrogesterone binds to blood proteins. Hydroxylated in liver cells. Elimination of biotransformation products occurs in urine (56-79%). 72 hours after a single dose it is completely eliminated from the body. It does not accumulate and there is no increase in the concentration of dydrogesterone in patients with renal failure.

Indications for
application:

Confirmed endogenous progesterone deficiency(endometriosis, luteal phase deficiency, habitual fetal loss or threatened abortion, premenstrual syndrome, menstrual irregularities, amenorrhea of ​​secondary origin, dysmenorrhea).
Hormone replacement therapy (surgical castration, including with a preserved uterus; menopausal syndrome - used when it is necessary to neutralize the proliferative effect of estrogens on the mucous membrane of the uterine cavity when using estrogens for HRT).

Mode of application:

Destination schemes are indicative. For maximum therapeutic action should be considered Clinical signs diseases and phases of the natural menstrual cycle. Daily dosage divided into several doses, preferably at regular intervals.

At endometriosis use 10 mg of dydrogesterone 2-3 times a day (without breaks or from the 5th to 25th day of the menstrual cycle).

At infertility progesterone genesis 20 mg/day (in 2 doses) from the 11th to 25th day of MC inclusive. The course of treatment is 3-6 months. If the patient becomes pregnant, treatment should be continued at the dose recommended for habitual loss pregnancy. The dose of dydrogesterone can be adjusted cytological examination vaginal epithelium (colpocytology).

Habitual pregnancy loss And threatened abortion– used only in case of evidence of endogenous progesterone deficiency.

In case of threatened abortion use 40 mg of dydrogesterone as a starting dose 1 time, then 10 mg every 8 hours for 1 week. After this, the dosage is gradually reduced. However, if signs of threatened abortion recur, it is possible to increase the dose again. Can be used up to 12-20 weeks of pregnancy.

With the usual miscarriage Therapy begins when planning pregnancy: 10 mg 2 times a day from the 11th to the 25th day of the menstrual cycle. If conception has occurred, therapy is carried out at the same dose continuously; from the 20th week of pregnancy, the dose is gradually reduced. Clarification of the need to increase or decrease the dosage of dydrogesterone is possible after a colpocytological study.

For premenstrual syndrome(PMS) – 10 mg from the 11th to the 25th day of the menstrual cycle. Duration of therapy – 3-6 months.

For dysmenorrhea - 20 mg/s in 2 doses from the 5th to the 25th day of the menstrual cycle, for 3-6 months.

With an irregular menstrual cycle, due to the short luteal phase, use 20 mg/day, in 2 divided doses from the 11th to the 25th day of the cycle.

In the treatment of amenorrhea used in combination with estrogens. Apply 10 mg of dydrogesterone 2 times a day from the 11th to the 25th day of the menstrual cycle while taking 0.05 ethinyl estradiol from the 1st to 25th day of the cycle. Duration of treatment – ​​3 or more menstrual cycles.

For dysfunctional bleeding used in a dose of 10 mg 2 times a day for 5-7 days in combination with ethinyl estradiol 0.05 mg (this regimen stops bleeding). For prophylaxis, use 10 mg of dydrogesterone 2 times per day from the 11th to 25th day of the menstrual cycle, combined with 0.05 ethinyl estradiol 1 time per day.

As HRT used only in combination with estrogens.
For continuous therapy, 10 mg is used for 14 days each menstrual cycle. When used cyclically - only in the last 12-14 days of estrogen 10 mg 1 r / s. If necessary (insufficient secretory transformations of the endometrium, confirmed by ultrasonography or histologically), the dose is increased to 20 mg/day.

Side effects:

Rarely– breakthrough bleeding. In this case, the dose of dydrogesterone must be increased. Can also be customized increased sensitivity to the drug.

Contraindications:

Undiagnosed vaginal bleeding;
- existing severe liver disease or presence serious illnesses liver in the past, if liver function tests have not returned to normal;
- the use of estrogens in combination with progestogens, such as dydrogesterone;
- established hypersensitivity to active substance or to any other component of the drug;
- established or suspected neoplasms dependent on sex hormones.

Interaction
other medicinal

"Duphaston" is a synthetic progesterone (gestagen), the use of which is aimed at combating progesterone deficiency. With restoration hormonal levels and the reproductive function of a woman, the product copes quite successfully, but not everyone can afford treatment with its help. Therefore, it will be useful to understand the purpose of the drug, instructions for use, contraindications to its use and analogues of Duphaston.

Composition (active ingredient) of Duphaston

Duphaston includes:

• main substance – dydrogesterone;
• lactose monohydrate;
• starch;
• pyrogenic silicon dioxide;
• stearic acid;
• E171;
• agalite

This combination of components controls the correct development of the endometrium and suppresses estrogen, restoring the amount of female hormones.

The tablets are packaged in blisters in the amount of 20 pieces.

Cheap Russian analogues

The average cost of the drug is 600 rubles. This price of the drug determines the demand for cheap analogues of Duphaston.

Substitutes for Duphaston include the following drugs:

1. "Progesterone". Its action is aimed at normalizing the environment for the development of the egg. The product is available in the form of a solution for intramuscular administration. Price - from 570 rub.
2. "Pregnin." Prepares the endometrium for egg implantation, reduces uterine tone and has a positive effect on lactation. Pregnin is available in tablet form. Price - from 400 rub.
3. Dydrogesterone is the active ingredient in Duphaston. Can be taken during pregnancy. Price - from 450 rub.
4. "Ingesta". Progesterone-based drug for the treatment of amenorrhea, uterine bleeding and infertility. "Ingesta" helps maintain pregnancy and has a minimum of contraindications. Price - from 95 rub. (cheapest Russian analogue"Duphaston" on the pharmaceutical market).

Of the foreign analogue products, the most popular is Utrozhestan (Belgium). But the drug is clearly inferior to Duphaston due to big list side effects (drowsiness, headaches, increased fatigue, etc.).

The use of any analogue drugs must be approved by the attending physician.

Instructions for use of the drug

Taking the Duphaston tablet results in the absorption of dydrogesterone into the blood. Next, the substance is evenly distributed throughout the body, having a direct effect on reproductive function. The drug should be used in dosages recommended by the doctor, since they are prescribed based on many factors (pathology, presence of menstruation, etc.).

Duphaston during pregnancy

Taking Duphaston during pregnancy is permitted only with the consent of your doctor. This drug helps many women with problems reproductive system maintain a healthy pregnancy, eliminating the threat of spontaneous abortion.