Is it an analogue of Duphaston? Consequences of excessive dosage
Infertility is dangerous diagnosis and a terrible sentence for every woman who sees her future in happy motherhood. When treating this disease, in some cases the question arises, what can replace Duphaston, but what is this connected with?
The essence of the problem
Before we talk about correction hormonal pattern treatment, it is necessary to recall that Duphaston has virtually no contraindications, and is approved for use by all women with the exception of patients with increased intolerance to the active components. Such cases are extremely rare, but nevertheless, in obstetric practice they have been recorded more than once. In addition, it is worth noting that this particular drug does not always help in the treatment of infertility; for example, six-month therapy with low effectiveness requires immediate correction.
If the problem is ovulation or its complete absence, then the female body needs additional progesterone, which is produced in non- sufficient quantity. That is why it is necessary to additionally take Duphaston or another analogue for the timely regulation of hormonal levels, menstrual cycle and successful ovulation.
Worthy analogue
Many patients ask the standard question: is it possible to replace Duphaston with Utrozhestan? Most often, the answer is yes, since the characteristic medication has a similar composition, pharmacological effects to the site of pathology. But what is known about this medicine? Unlike Duphaston, progesterone in chemical formula not synthesized, but presented in in kind, which increases the chances of successful conception.
The use of a typical medication is appropriate not only in obstetrics, but also in modern gynecology, and among the indications are not only diagnosed infertility, but also others no less dangerous diseases. Among these are the following:
- threat and prevention of miscarriage;
- menopause and climatic syndrome;
- mastopathy of the mammary glands;
- premenstrual syndrome;
- disrupted menstrual cycle;
- endometriosis and its prevention;
- prevention of uterine fibroids.
Contraindications and side effects
Utrozhestan has a gentle effect on the female body, and among the contraindications in the instructions are hypersensitivity and the lactation period. It is also not recommended to take the drug if you are prone to uterine bleeding, if you suspect malignant neoplasms, as well as in case of impaired blood clotting. This is where the list of restrictions ends, but side effects occur quite often, and on numerous online sites, patients reflect in detail all their dissatisfaction with such a prescription.
Most often, anomalies prevail at the very beginning of use, when the body is just getting used to an additional source of progesterone, and is not always ready for such radical changes. Doctors identify the following anomalies that progress in particularly weakened organic resources:
- frequent dizziness, less often - fainting;
- increased drowsiness;
- nervous excitement;
- skin rash;
- attacks of headache, migraine;
- Quincke's edema;
- hemolytic anemia;
- hives and itching;
- passivity and decline in performance;
- absent-minded attention;
- signs of dyspepsia;
- depressed state.
If characteristic anomalies occur, there is no need to rush to discontinue the drug; perhaps a dose adjustment is sufficient to achieve positive dynamics of the disease. Otherwise, a replacement will be required, and the effect of the new analogue in the body is most unpredictable.
Directions for use and doses
the medical drug is available in the form of capsules intended for oral and vaginal use. One pill contains 100 mg of natural progesterone, but the method of use is determined by the treating gynecologist individually.
In order to prevent a particular diagnosis, the specialist recommends internal reception hormone, and it is very important to maintain the prescribed daily standards. If this is a treatment for diagnosed infertility, then doctors also stop at oral administration Utrozhestan. But to maintain a pregnancy when there is a threat of miscarriage, it is preferable vaginal use capsules, but taking it internally as a complex will also not hurt.
Utrozhestan has a lot of advantages, and such advantages are difficult to deny. For example, in case of early toxicosis of a pregnant woman, it is better to insert capsules vaginally, and the therapeutic effect is identical. Besides, sedative effect has a positive effect on the excited nervous system, and progesterone also helps eliminate stagnation in the female body.
It is very important that the drug corresponds to the expiration date, and is prescribed by a doctor, and not by a friend following her example. The effectiveness is noticeable after 2 - 3 months of regular use, however, each patient has her own individual treatment characteristics.
Other analogues
If the drug Duphaston is suitable according to indications, but contraindications limit its systematic use, then in addition to the hormonal drug Utrozhestan, there are other sensational analogues that are also effective in the presented conditions. clinical pictures. But what kind of medications are we talking about?
Most often these are names such as Utrozhestan and Prajistan, which are considered a worthy alternative with a sufficient amount of synthetic progesterone necessary to correct the menstrual cycle, hormonal levels and ensure successful conception. These drugs are patented in Russia, are widely used in gynecological and obstetric practice, and show a stable therapeutic effect even in seemingly hopeless clinical situations.
If the medication Duphaston is not suitable, the patient should not engage in superficial self-medication, since the underlying disease will still not see positive dynamics. First of all, you need to contact a specialist, and then clinically will select the most effective replacement, a worthy analogue. There is no complete analogue of typical medications, and it is important not to forget about this when adjusting the treatment regimen.
It only remains to add that all the medications presented are hormonal based, that is, they have a direct effect on hormonal background. That is why you should not rule out such anomalies as unexpected weight gain or increased body hair. It is important to note this question in order to keep it in shape and presentable. appearance. However, such cases are very rare, so the patient may not worry about common fears in terms of taking “hormones”.
If the use of the hormonal drug Duphaston is strictly contraindicated, only the attending physician - a gynecologist - can advise what can replace such a prescription. If such a replacement is required during pregnancy to preserve its viability, then it should definitely be the drug Utrozhestan, available without an additional prescription. A typical drug can be taken orally and vaginally, which will significantly enhance the desired therapeutic effect.
It's no secret that every year the state environment significantly deteriorates, which has a detrimental effect on people's health. Without the help of medications, many women cannot conceive and bear a child. But science does not stand still: many drugs appear that not only increase the likelihood of the desired pregnancy, but also bring it back to normal. women Health. One of these medicinal “helpers” for the fair sex is Duphaston. But not only this drug helps restore hormonal balance female body and allows you to make your dream of having a baby come true. The doctor can also prescribe an analogue of Duphaston, and more than one. But let’s try to figure it out which one is better.
Why is Duphaston so good?
Before considering which drug can be a worthy alternative to this medicine, you should understand what properties it has and how it affects the woman’s body.
So, dydrogesterone, which is the basis of the drug, according to molecular structure, pharmacological and chemical properties close to natural progesterone. It is the deficiency of this hormone that can deprive a woman of the joy of motherhood. Despite the fact that it is a testosterone derivative, side effects does not have a hormone. It is worth noting that this characteristic is a huge advantage of the medicine. The same cannot be said about many synthetic progestogens, which are necessary components of hormone replacement therapy. Among other things, the drug does not affect the metabolism of carbohydrates and the functioning of the liver, its effect does not affect the processes of ovulation and metabolism.
Pharmacokinetics
A special feature of the drug "Duphaston" is that it quickly comes from gastrointestinal tract V bloodstream. The maximum concentration in the blood after taking the tablets is observed after 2 hours. Further, 97% of dydrogesterone binds to proteins and is hydroxylated in liver cells.
results clinical trials confirm that about 64% of the dose of dydrogesterone is excreted naturally, with urine. Thanks to this, it becomes possible to determine the endogenous level of progesterone. The instructions will help you obtain more specific information about the pharmacokinetics of the drug Duphaston.
Analogues of the drug do not have the properties mentioned above.
Indications for use
Before considering medications that can replace Duphaston, you should understand for what female problems it is prescribed.
Most often, doctors recommend taking the drug Duphaston to women who have been diagnosed with progesterone deficiency. A low level of this particular hormone in a woman’s body is the cause of many troubles, such as the threat of fetal loss, menstrual irregularities, dysmenorrhea, premenstrual syndrome, infertility, secondary amenorrhea, dysfunctional uterine bleeding.
For all of the above ailments and conditions, doctors do not prohibit taking an analogue of Duphaston tablets, but if the budget allows, they recommend using the original drug.
How can I replace Duphaston?
Today, the most famous and most often used drug, which can fully replace the drug Duphaston, is Utrozhestan. But, fortunately, scientists did not stop at developing only this medicine. Therefore, today a woman who wants to conceive and safely carry a baby can acquire the most suitable option from a wide range of drugs. Of course, it is worth noting that this choice must be made entirely by the doctor, taking into account individual characteristics patients. But situations in life are different, therefore, after consulting with a pharmacist, you can independently purchase a worthy analogue of Duphaston.
The drug "Urozhestan"
The drug "Utrozhestan" is produced on the basis of plant raw materials diogenin - a Mexican plant, better known as wild yam. It has an antiandrogenic effect and neutralizes the effects of oxytocin, which causes uterine hypertonicity. Also, this Russian analogue of Duphaston has a sedative effect that is useful for pregnant women, but does not predispose to weight gain and does not affect the removal of fluid from the body.
Advantages and disadvantages of the drug "Utrozhestan"
A distinctive negative characteristic of this drug is a significant number of side effects, which are not observed when using Duphaston tablets. This may include increased fatigue, dizziness, drowsiness, general malaise, confusion and other reactions.
But it is worth noting that the above side effects fully compensate for the advantageous characteristics of the drug. Thus, the medicine “Utrozhestan” can be used both orally and intravaginally. This allows the drug to be prescribed not only to pregnant women with early toxicosis, but also to achieve maximum therapeutic results in the development of other pathologies in expectant mothers.
The benefits of the medicine include its cost. After all, this analogue of Duphaston is an order of magnitude cheaper than the original. But it is worth remembering that it is strictly prohibited to independently replace the prescribed medicine. Therefore, before you buy this more affordable medication, you should consult your doctor, especially if we're talking about about maintaining the desired pregnancy.
Dydrogesterone remedy
Like the drug Duphaston, its analogs replenish the deficiency of progesterone in a woman’s body. In particular, the drug "Dydrogesterone" helps maintain the beneficial effect of estrogen on lipid profile blood. The active ingredient of the drug does not affect coagulation parameters, as well as carbohydrate metabolism and liver function. In addition, the advantages of the drug include the absence of androgenic, estrogenic, thermogenic, corticoid or anabolic activity.
Today, Dydrogesterone is a good and affordable Russian analogue of Duphaston. This synthetic progestogen is indicated for endogenous progesterone deficiency.
Remedy "Prajisan"
This modern analogue"Duphaston" is hormonal agent with progesterone. It is used in the treatment of long-term infertility, as well as luteal phase deficiency. Effective when various violations menstrual cycle, premenopause, fibrocystic mastopathy and other ailments.
Since the drug has a wider spectrum of action than Duphaston, it is used only before pregnancy. Exceptions are cases when the benefit to the mother's body exceeds possible risk negative impact for the fruit.
Which analogue is better?
Only doctors have the right to talk about what medicine can replace Duphaston. Analogs of the drug are selected by a professional, taking into account all the individual characteristics of the patient and the complexity of her disease. Self-appointment medications in this group can harm the health of both the mother and the baby, and sometimes cause spontaneous abortion (if the drug is abruptly discontinued).
Name:
Duphaston
Pharmacological
action:
Dydrogesterone, which is the active substance of duphaston, - progestogen, an analogue of natural progesterone. It has no estrogenic, androgenic or corticoid effect. Does not change thermogenesis, so the presence of ovulation can be determined by monitoring basal temperature bodies. Does not affect metabolism. There are no side effects associated with the use of synthetic progestins. Effective when used internally. Selectively affects progestin receptors of the uterine mucosa. Causes normal secretory transformations in the endometrium in case of sufficient estrogen saturation. Does not affect follicle ovulation. Does not have a virilizing and/or masculinizing effect (including on the fetus).
After oral administration quickly absorbed from the gastrointestinal tract. The maximum concentration in the blood after administration is observed In 2 hours. 97% of dydrogesterone binds to blood proteins. Hydroxylated in liver cells. Elimination of biotransformation products occurs in urine (56-79%). 72 hours after a single dose it is completely eliminated from the body. It does not accumulate and there is no increase in the concentration of dydrogesterone in patients with renal failure.
Indications for
application:
Confirmed endogenous progesterone deficiency(endometriosis, luteal phase deficiency, habitual fetal loss or threatened abortion, premenstrual syndrome, menstrual irregularities, amenorrhea of secondary origin, dysmenorrhea).
Substitute hormone therapy
(surgical castration, including with a preserved uterus; menopausal syndrome - used when it is necessary to neutralize the proliferative effect of estrogens on the mucous membrane of the uterine cavity when using estrogens for HRT).
Mode of application:
Destination schemes are indicative. For maximum therapeutic action should be considered Clinical signs diseases and phases of the natural menstrual cycle. Daily dosage divided into several doses, preferably at regular intervals.
At endometriosis use 10 mg of dydrogesterone 2-3 times a day (without breaks or from the 5th to 25th day of the menstrual cycle).
At infertility progesterone genesis 20 mg/day (in 2 doses) from the 11th to 25th day of MC inclusive. The course of treatment is 3-6 months. If the patient becomes pregnant, treatment should be continued at the dose recommended for habitual loss pregnancy. The dose of dydrogesterone can be adjusted cytological examination vaginal epithelium (colpocytology).
Habitual pregnancy loss And threatened abortion– used only in case of evidence of endogenous progesterone deficiency.
In case of threatened abortion use 40 mg of dydrogesterone as a starting dose 1 time, then 10 mg every 8 hours for 1 week. After this, the dosage is gradually reduced. However, if signs of threatened abortion recur, it is possible to increase the dose again. Can be used up to 12-20 weeks of pregnancy.
With the usual miscarriage Therapy begins when planning pregnancy: 10 mg 2 times a day from the 11th to the 25th day of the menstrual cycle. If conception has occurred, therapy is carried out at the same dose continuously; from the 20th week of pregnancy, the dose is gradually reduced. Clarification of the need to increase or decrease the dosage of dydrogesterone is possible after a colpocytological study.
For premenstrual syndrome(PMS) – 10 mg from the 11th to the 25th day of the menstrual cycle. Duration of therapy – 3-6 months.
For dysmenorrhea - 20 mg/s in 2 doses from the 5th to the 25th day of the menstrual cycle, for 3-6 months.
With an irregular menstrual cycle, due to the short luteal phase, use 20 mg/day, in 2 divided doses from the 11th to the 25th day of the cycle.
In the treatment of amenorrhea used in combination with estrogens. Apply 10 mg of dydrogesterone 2 times a day from the 11th to the 25th day of the menstrual cycle while taking 0.05 ethinyl estradiol from the 1st to 25th day of the cycle. Duration of treatment – 3 or more menstrual cycles.
For dysfunctional bleeding used in a dose of 10 mg 2 times a day for 5-7 days in combination with ethinyl estradiol 0.05 mg (this regimen stops bleeding). For prophylaxis, use 10 mg of dydrogesterone 2 times per day from the 11th to 25th day of the menstrual cycle, combined with 0.05 ethinyl estradiol 1 time per day.
As HRT used only in combination with estrogens.
For continuous therapy, 10 mg is used for 14 days each menstrual cycle. When used cyclically - only in the last 12-14 days of estrogen 10 mg 1 r / s. If necessary (insufficient secretory transformations of the endometrium, confirmed by ultrasonography or histologically), the dose is increased to 20 mg/day.
Side effects:
Rarely– breakthrough bleeding. In this case, the dose of dydrogesterone must be increased. There may also be individual hypersensitivity to the drug.
Contraindications:
Undiagnosed vaginal bleeding;
- existing severe liver disease or presence serious illnesses liver in the past, if liver function tests have not returned to normal;
- the use of estrogens in combination with progestogens, such as dydrogesterone;
- established hypersensitivity to active substance or to any other component of the drug;
- established or suspected neoplasms dependent on sex hormones.
Interaction
other medicinal
Most patients need long-term use medicines, sometimes it is not possible to buy the drug in sufficient quantities to pass full course, which forces them to look for cheap analogues of Duphaston. But are there any? And if so, how do they correspond to the prescribed remedy?
Duphaston- common in gynecological practice a drug containing a synthetic analogue of progesterone (the hormone responsible for normal course pregnancy) and used for:
- endometriosis;
- disorders of the menstrual cycle (dysmenorrhea, secondary amenorrhea);
- infertility resulting from luteal insufficiency;
- uterine bleeding;
- menopause or similar disorders of the female reproductive system as a means of replacement therapy;
- premenstrual syndrome.
Criterias of choice
Analogues of the drug Duphaston should not only differ from it in price (downwards), but also have the same spectrum therapeutic activity(treat for the same or most of the diseases specified in the instructions for its use). However, they may not be absolutely identical and may not contain the same active ingredient. Therefore, when reviewing medicines we will divide them into two conditional groups.
Necessary warning: all of the “Duphaston substitutes” listed below, despite the fact that data from reliable sources were used in their search, in no case replace the recommendations of the attending physician or cancel his prescriptions. And therefore, if it is necessary to change the drug to one of those provided in this article (except for specified cases), we strongly recommend notifying a specialist and undergoing additional consultation in order to prevent the occurrence of possible complications.
Identical drugs
Complete analogues of Duphaston are:- Duphaston;
- Dydrogesterone.
Duphaston: most likely this drug was just released a little later than the other pharmaceutical company. The only possible difference from the fixed asset is the price, which can be either lower or higher (depending on the place of sale). Possible differences: minor differences in additional components.
Dydrogesterone: active component of a fixed asset in pure form. The most complete and reliable analogue of tablets, and its price is several times lower than that of Duphaston. However, do not rush to rejoice: it is so rare in pharmacies that it is almost impossible to find it. This is especially true for small towns in remote regions. As for additional components, then their list is minimal and, most likely, they serve only to form a dosage form.
Means with similar effects
This group includes drugs containing active components similar to progesterone. All of them can be used to treat diseases listed in the indications for Duphaston.Utrozhestan(Utrogestan) is an analogue of Duphaston from Thailand, which as an active component contains natural micronized progesterone obtained from volunteers or animals. Hence - more high efficiency and a relatively low probability of occurrence allergic reactions(hormones do not contain an antigenic structure and act equally well in various types animals). However, the drug is contraindicated for bleeding from birth canal women unknown origin and may cause drowsiness, which is why it is contraindicated for those who are busy active species activities or driving vehicles.
Progesterone(Progesterone) - a Russian analogue of Duphaston, containing a gestagen hormone corpus luteum. Despite the obvious difference in active component, it is used in the same cases as the main drug. A significant difference - the latter is produced exclusively in dosage form For injection, which makes it somewhat difficult independent use, which allows it to be used in a hospital setting. But it leads to achievement much faster therapeutic effect than tablet forms and, as a result, can become the drug of choice for especially severe forms spontaneous abortion.
What we have
Small list available analogues, which may still provide some choice for buyers:- Duphaston;
- Dydrogesterone;
- Utrozhestan;
- Progesterone.
Duphaston is a medicine, a substitute for natural progesterone (main active substance- dydrogesterone).
The drug is prescribed for deficiency of the specified female hormone(regardless of the cause of the problem). Duphaston selectively affects the endometrium, does not affect metabolism, and does not affect liver function.
Indications for use of the drug
- endometriosis (abnormal growth epithelial tissue lining inner surface uterus);
- infertility caused by a deficiency of progesterone in the body;
- unstable menstrual cycle;
- uterine bleeding.
The release form of Duphaston is tablets (10 mg). The cost of the product ranges from 491 to 671 rubles. Take the medicine orally in a dosage determined by your doctor.
Taking the drug is associated with a number of side effects - migraines, minor disruptions in the functioning of the gastrointestinal tract, hypersensitivity mammary glands, general malaise, jaundice skin, systemic and local allergic reactions.
Despite this, Duphaston is rightfully recognized as one of the safest and most accessible (albeit expensive) drugs in its pharmacological group.
Please note: when individual intolerance patients individual components Duphaston, there is a need to select a drug - an analogue with similar clinical properties.
How to replace medicine
Pharmacies sell cheaper medications - analogues of Duphaston made in Russia and abroad.
Domestic analogues
Let's consider effective domestic medicines.
Progesterone
The average cost is 578 rubles. Hormonal drug, whose main task is to create the maximum comfortable conditions for the maturation of a fertilized egg.
Release form - solution in ampoules, intended for intramuscular injection.
Pregnin
Price from 450 rubles. A synthetic substitute for the female hormone progesterone, has a positive effect on the structure of the endometrium and reduces the tone of the uterus during pregnancy. Available in tablets.
Ingesta
Most cheap analogue Duphaston, his price at the pharmacy - from 95 rubles. The main component is progesterone. The drug is prescribed to patients with amenorrhea, uterine bleeding, and infertility.
Foreign substitutes
Duphaston analogues of foreign production.
Utrozhestan 
From 300 rubles/pack. The most accurate, cheaper “copy” of the study drug is produced in Belgium. Available in the form of capsules, suppositories, and used orally and intravaginally.
Despite the moderate cost, Utrozhestan is inferior in popularity to Duphaston due to wide range side effects.
Thus, with regular use of the medicine, patients may experience dizziness, increased fatigue, weakness, drowsiness, general malaise.
Reviews about the drug are as follows.
Iprozhin
Price at the pharmacy - from 381 rubles/pack. The drug is a joint production of France and Italy. Refers to drug group gestagens. Good clinical effect demonstrates in the treatment of endometriosis, in the fight against PMS, mastopathy. Iprozhin is prescribed to patients who are about to undergo an IVF procedure (to prepare the uterus for bearing a fetus).
Crinon
From 2565 rubles. Effective gel British and German production. Used intravaginally, it provides additional “release” of the vaginal mucosa of the hormone progesterone.
Prajeesan
From 325 rubles. Indian capsules based on progesterone, soy lecithin and peanut butter. Effective and safe analogue Duphaston.
Megays
An expensive American analogue of Duphaston (from 2,700 rubles) based on megestrol, available in tablets. Belongs to the medicinal group of gestagens, demonstrates good clinical effect in the fight against endometrial cancer and anorexia.
Criterias of choice
Absolutely identical in composition and properties to Duphaston pharmaceutical drugs does not exist.
