Corvalol instructions for use in drops contraindications. Corvalol: components, how it works, instructions for use, to whom it is indicated, contraindications

Many medicines sold in the public domain are considered more than safe by users. They can often be found in any home medicine cabinet, and such drugs can be taken literally “at random” - in any suitable situation. But even the most seemingly safe medications can cause harm if used incorrectly. This also applies to Corvalol, a popular remedy among heart patients. Let's look at what the instructions for using the drug "Tincture of Corvalol" inform us about, the benefits and harms that this medicine can cause.

Corvalol tincture: instructions for use

What is the composition of the medicine “Tincture of Corvalol”?

The active ingredients of Corvalol are ethyl bromizovalerianate (ethyl ester of alpha-bromoisovaleric acid), phenobarbital and peppermint oil. This medicine also contains several auxiliary components - sodium hydroxide, ethanol and purified water.

The medicine looks like a clear liquid without coloring. It has a rather specific aromatic smell.

What is the effect of Corvalol Tincture?

Corvalol is a sedative and antispasmodic drug. Its effect on the body is determined by its constituent components. Thus, the ethyl ester of alpha-bromoisovaleric acid has reflex and antispasmodic qualities, which are explained mostly by irritation of receptors located in the oral cavity and nasopharynx, as well as a decrease in reflex excitability in the central regions of the nervous system, and activation of inhibition within the neurons of the cortex and subcortical structures in the brain brain.
Also, such qualities of this substance lead to a decrease in the activity of the central vasomotor centers. Ethyl ester of alpha-bromoisovaleric acid also has a local antispasmodic effect on smooth muscles.

As for phenobarbital, it greatly enhances the calming effect of other components, reduces central nervous system excitation and significantly facilitates falling asleep.

Peppermint oil has reflex vasodilating, antispasmodic, mild choleretic and antiseptic properties. This substance irritates cold receptors, which are located in the mucous membranes of the oral cavity, and reflexively dilates blood vessels in the heart and brain. Peppermint oil is good at eliminating flatulence due to irritation of receptors located in the mucous membranes of the digestive tract, which in turn activates intestinal motility.

What are the indications for use of the drug “Tincture of Corvalol”?

Corvalol tincture is usually recommended for use as a symptomatic (sedative and vasodilator) medicine for.
It is also recommended to use it for correction, which are accompanied by excessive irritability. Corvalol tincture copes well with sleep disturbances and a state of agitation in which pronounced vegetative manifestations are observed. This medicine can be used as an antispasmodic - to eliminate intestinal spasms.

What is the use and dosage of the medicine “Corvalol Tincture”?

The dose of Corvalol tincture is selected individually. The medicine is taken immediately before a meal, dissolved in a small amount of water (thirty to fifty milliliters).

Adults are usually recommended to take thirty drops of Corvalol. To correct tachycardia, the single dose can be slightly increased - up to forty to fifty drops. Adults should take this remedy twice or thrice a day.

In childhood (from three years old), Corvalol is used one drop for each year of the baby’s life - this is a one-time dosage. The advisability of using the second and subsequent doses is determined solely by the doctor on an individual basis.

The duration of treatment with Corvalol is also determined by a specialist.

What are the contraindications for use of the drug “Corvalol Tincture”?

Corvalol tincture is contraindicated if the patient is overly sensitive to its components, as well as with severe impairment of the kidneys or liver. This medicine is not used during breastfeeding. Also, you should not use it during pregnancy.
The instructions for use of the drug “Tincture of Corvalol” also prohibit its use for alcoholism, traumatic brain injuries, brain diseases and in children under three years of age.

What are the side effects of Corvalol Tincture?

It is worth noting that Corvalol tincture can cause a number of unpleasant side effects, such as drowsiness, dizziness and slow heart rate. Some patients also experience various types of allergic reactions. With prolonged use, this drug can cause bromism, dependence (addiction) and, as a result, withdrawal syndrome.

Benefits of Corvalol

Corvalol is great for one-time use for anxiety, pain and discomfort in the heart. It is able to eliminate the negative effects of stress, nervousness and insomnia.

Is Corvalol tincture dangerous? Is it possible to cause harm?

The active components of Corvalol can accumulate in the body, causing dependence. With prolonged use and abrupt cessation, withdrawal syndrome occurs, manifested by sleep disturbance, memory impairment, anxiety and depression. Excessive consumption of Corvalol can cause a number of unpleasant symptoms - central nervous system depression, nystagmus and ataxia, hypotension, agitation, etc.

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In our turbulent times, every second person suffers from nervous system disorders: irritability, anxiety, insomnia, stress. It is for this reason that sedatives, sleeping pills and antidepressants are so popular. On the modern pharmacological market you can find dozens of medications that normalize the functioning of the nervous system, but many patients still prefer the long-known Corvalol.

The drug is based on menthol, ethylbromoisovalerate and phenobarbital and has a calming, antispasmodic effect. It is extremely popular due to its ease of use, low cost and effectiveness. However, this drug is potentially dangerous if taken incorrectly, as it contains artificial psychotropic substances and a high concentration of ethanol.

Corvalol - description of the pharmaceutical form

Corvalol is a combination drug based on herbal and artificial components. It is a structural analogue of Valocordin, which was released for sale in Germany before the war. In modern times, the drug is quite popular in Russia and other countries of the former USSR, as well as Asia. In Europe and the USA it was banned long ago due to the phenobarbital it contains.

The main components of Corvalol are ethyl bromizovalerianate, phenobarbital and menthol oil.

Corvalol is available in two pharmaceutical forms - tablets and drops. Drops are considered the most popular due to their ease of use and rapid therapeutic effect.

Corvalol drops contain the following substances:

α-bromoisovaleric acid ethyl ester (ethyl bromoisovalerianate);
phenobarbital;
menthol oil;
ethanol (96%);
distilled water;
sodium isovalerate.

The solution contains about 50% ethanol. In appearance, it is a colorless liquid with a menthol aroma.

The composition of Corvalol drops may vary slightly. For example, Corvalol N tincture, in addition to the active substances described above, contains hop oil. As additional components: sodium acetate trihydrate, acetic acid solution, water, ethanol (96%).

The drug provides a sedative, vasodilator and antispasmodic effect.

Component Properties

Corvalol eliminates spasm of smooth muscles, has a sedative effect and can help with mild sleep disorders. The therapeutic effect of the drug is determined by its components.

Ethylbromoisovalerate and alcohol affect the receptors of the inner lining of the mouth and pharynx, reduce the excitability of the central nervous system, and provoke an inhibitory effect on the cerebral cortex and subcortical nerve centers. Thanks to these substances, the drug has an antispasmodic and sedative effect similar to Valerian tincture. In large dosages, the sedative exhibits a pronounced hypnotic effect.

Phenobarbital has a sedative effect; this substance inhibits the transmission of nerve impulses to the cortex and subcortex of the brain. This component helps relieve irritation, under its influence the patient feels drowsiness, and the reaction rate decreases. The degree of suppression of excitatory impulses depends on the portion of drops: the recommended dose will have a calming effect, and in case of an overdose, a pronounced hypnotic effect will appear.

Corvalol has a sedative, antispasmodic, vasodilator effect

The components of Corvalol inhibit the activity of the vasomotor (vasomotor) center. Phenobarbital relaxes vascular smooth muscle, resulting in a moderate hypotensive effect of the drug. However, when blood pressure increases, it is recommended to take other medications; Corvalol is not suitable for this purpose. The drops slightly reduce blood pressure, but they are not able to eliminate the excessive increase in blood pressure during a hypertensive crisis.

Menthol oil is an antispasmodic, promotes vasodilation, enhances intestinal motility, eliminating excess gas formation. Thanks to peppermint oil, the drops have a pleasant refreshing taste and a disinfecting effect.

The tincture is taken before meals, first dissolved in a small dose of filtered water or by dropping the required portion onto refined sugar.

Many patients are interested in the question of how long it takes for Corvalol to work. The therapeutic effect appears 20 minutes after administration and lasts for 3–6 hours. Most of the medicine begins to be absorbed through the oral mucosa.

In patients who have previously taken medications with barbituric acid, the therapeutic effect is reduced due to the rapid metabolism of phenobarbital in the liver.

Purpose of Corvalol

Patients are interested in the question of what the drug helps with. Corvalol drops are not a medicine, it is a symptomatic drug that is used to relieve certain signs of mental disorders. That is, the remedy is not able to cure heart disease, renal colic, and insomnia. Some will disagree, because after taking the drops, the pain in the heart really disappears. However, the medicine can relieve pain as a result of stress or a nervous breakdown. But if we are talking about pain due to angina or heart attack, then Corvalol will not help.

Corvalol is prescribed to eliminate symptoms of neurotic disorders

The tincture is taken to calm the nerves and fall asleep easier, but they will not help if you have developed stress or anxiety disorder. Every patient who takes drops for a long time knows about this.

Some patients take the drug for so long that they become dependent on it and use it on every occasion. However, Corvalol is recommended to be taken as prescribed by a doctor, since many symptoms (pain in the left side of the chest, kidneys, insomnia) require clarification of the cause and adequate treatment.

Indications for use of Corvalol:

Neurotic disorders.
Vegetative-vascular dystonia, arterial hypertension (complex treatment).
Insomnia.
Tachycardia, spasm of the coronary arteries (if the symptoms are mild).
Intestinal spasm due to neurovegetative disorders.

Thus, Corvalol drops are able to eliminate pain due to nervous experiences, and not against the background of structural changes in the coronary vessels or heart muscle.

Precautionary measures

As indicated in the instructions for use of Corvalol in drops, the drug is prohibited in the following cases:

Intolerance to the ingredients of the drug.
Allergy to bromine.
Chronic heart failure (severe).
Hepatic porphyria.

Corvalol is contraindicated in case of allergies not to its components

In addition, drugs containing phenobarbital are prohibited from being taken by patients with heart attack (acute form), low blood pressure, stress, or diabetes. The use of Corvalol is contraindicated in patients with dependence on drugs, medications, or alcoholic beverages. This restriction applies to patients with impaired air flow through the bronchi due to narrowing or blocking of the air ducts, as well as for diseases of the respiratory organs with shortness of breath.

Under the supervision of a doctor, patients with epileptic seizures and severe liver diseases take a sedative. The tincture is allowed to be given to children only for medical reasons, and it is important to constantly monitor their condition.

Negative effects of tincture on humans:

epigastric discomfort, difficulty defecating, nausea, vomiting, impaired liver function;
neuromuscular disorders, involuntary eye movements of high frequency, slow reaction speed, dizziness, hallucinations, etc.;
allergic reactions (including angioedema);
disturbance of blood composition (decrease in the concentration of granulocytes, platelets, anemia);
difficulty breathing;
hypertension, bradycardia.

Long-term use of Corvalol is harmful to health, in which case the likelihood of osteogenesis imperfecta (impaired bone formation) and the manifestation of symptoms of bromism (chronic bromine poisoning) increases: inhibition of the nervous system, stress, ataxia, disorientation, etc. If such signs appear, you should stop taking it drops and consult a doctor.

Dosage of Corvalol

Many patients are interested in the question of how to take Corvalol. As indicated in the instructions, the medicine should be taken by first mixing it with 50 ml of filtered water or dropping it on a piece of sugar. The correct time to take drops is 30–60 minutes before meals.

Drops are diluted with water and taken before meals

The dosage of the medicine depends on the symptoms, as well as the age of the patient. The usual dose of Corvalol is from 15 to 30 drops. For slight spasm of the heart vessels or tachycardia, take 40 to 50 drops. To make it easier to fall asleep, drink 30 drops of the tincture, after mixing it with water, half an hour before bed.

The second pressing question: “How often can you take Corvalol?” The frequency of taking the medicine depends on the clinical picture and age of the patient. Sometimes the drug is used once, and in other cases the recommended dose is 3 times a day.

Drug danger

Many people know about the beneficial properties of the sedative, but not everyone realizes how harmful Corvalol is if the rules for its use are violated. For example, ethyl ester of α-bromoisovaleric acid is a substance that has an antispasmodic effect. Depending on the portion of drops, the drug exhibits a sedative or hypnotic effect. This dosage is determined for each patient individually.

If the rules of administration are violated, the drug causes dangerous complications.

Phenobarbital, which enters the body after consuming the usual dose of the drug (15 to 20 drops), causes a vasodilator and moderate sedative effect. The hypnotic effect does not appear after taking such a portion of drops.

Menthol oil also dilates blood vessels and relaxes smooth muscles. But when using a dose of 25 mg drops or more, intestinal motility decreases and constipation occurs.

In many European countries and the USA, the active ingredients of Corvalol are prohibited. For example, phenobarbital is dangerous for people, as it is considered a narcotic substance that provokes addiction. With systematic use of Corvalol, this component provokes a decrease in cognitive functions: speech disorders, loss of short-term memory, unsteadiness when walking. In addition, the likelihood of neurological disorders, withdrawal symptoms, and sexual disorders increases.

With prolonged use of drops, the risk of bromine accumulation in the body and the development of intoxication increases.

Degrees of poisoning:

Mild – general weakness, desire to sleep, muscle weakness, absent-mindedness, speech impairment, apathy, purpura (accumulation of blood under the skin, mucous membranes), etc.
Average – pathologically prolonged sleep, involuntary secretion of saliva, increased, decreased muscle strength up to paralysis, hypotension, decreased amount of urine, dilated pupils.
Severe - coma due to barbiturate intoxication, which is accompanied by respiratory failure, decreased reflexes, and loss of consciousness. In addition, blood pressure decreases, pathological noises occur during breathing, tachycardia, the skin and mucous membranes acquire a blue tint.

Functional heart failure continues to develop, after which the lungs often swell.

The lethal dose of drops is from 0.1 to 0.3 g/kg; the patient dies after taking 100 mg/kg of phenobarbital.

In case of mild intoxication, the stomach is washed and the victim is given enterosorbent drugs. In case of severe poisoning, cardiac massage and artificial respiration cannot be avoided. It is imperative to call an ambulance.

Complications of intoxication, even with timely assistance, are quite dangerous - severe forms of dermatitis, functional failure of the heart, respiratory organs or kidneys in acute form. Therefore, the dosage of drops must be correct.

Effect of the drug on blood pressure

The effect of active substances on blood pressure can also be quite dangerous. This applies to patients who have hypotension, because Corvalol provokes a decrease in blood pressure (BP). It is for this reason that it is sometimes used for hypertension. However, it is recommended to use specially designed medications for this purpose.

Corvalol lowers blood pressure

Doctors allow taking drops in emergency cases, when blood pressure rises sharply and there are no means at hand to lower it. The recommended dose is 45 drops per 100 ml of hot boiled water. The medicine must be taken quickly. The therapeutic effect appears after half an hour. Thus, Corvalol will help not only calm the nerves, but also save a person from a hypertensive crisis.

Compatibility of Corvalol with alcohol

Many people know that Corvalol drops and alcoholic drinks are a dangerous mixture. After all, ethyl alcohol enhances the effect of the sedative drug. For this reason, the tincture is contraindicated in patients with alcohol dependence.

Corvalol should not be combined with alcoholic beverages.

When taken together, hepatocytes (liver cells) are damaged and a disulfram-alcohol reaction develops.

After ethanol penetrates into the bloodstream, the heartbeat quickens, blood pressure rises, and the nervous system is excited. But the drops act the opposite, that is, they reduce blood pressure and calm the heart. As a result, an imbalance occurs and the body is overloaded.

Menthol oil dilates blood vessels and thins the blood. In this case, alcoholic drinks enhance the effect of the component, which threatens internal hemorrhages.

The most dangerous consequence of combining Corvalol with alcohol is cardiac arrest.

If a person often mixes the drug with alcoholic drinks, the likelihood of persistent drug dependence increases. This is due to the presence of phenobarbital in the tincture.

It is strictly forbidden to drink Corvalol during a hangover, since after such a “cocktail” liver enzymes are released faster and metabolic processes are accelerated. As a result, ethanol is absorbed into the bloodstream faster and exhibits its negative effect.

Corvalol for pregnant and lactating women

According to the instructions, expectant mothers are prohibited from taking Corvalol. This is explained by the presence of phenobarbital, ethanol and other aggressive substances in the medication. In the first trimester of pregnancy, the drug can cause pathologies in the development of the fetus. And after taking the drug before childbirth, the likelihood of respiratory failure in infants increases.

Drops are not recommended for use during pregnancy and lactation

Menthol oil increases the tone of the uterine muscles. That is why drinking Corvalol during pregnancy is prohibited, otherwise there is a risk of placental abruption and fetal death.

Thus, the components of the tincture are extremely harmful to the fetus, and therefore taking it during pregnancy is strongly not recommended. In case of emergency, you can take the minimum dose, but only after your doctor's approval.

The use of Corvalol during lactation is also prohibited, since the active substances are quickly absorbed into the blood and enter the baby’s body along with milk.

Similar means

There are a lot of drugs with a similar effect that can replace Corvalol:

Valerian
Doppelhertz Melissa
Corvaldin
Novo-Passit
Persen
Bromized
Notta, etc.

The closest in composition and principle of action are Corvalol and Valocordin

The most important analogue of Corvalol is Valocordin. The only difference between them is that Valocordin contains hop oil, which is absent in Corvalol drops. Otherwise, they are absolutely similar, this also applies to their actions.

Based on the foregoing, Corvalol drops are a fairly popular drug with a sedative, vasodilator, local anesthetic, antispasmodic, and also mild hypnotic effect. The symptomatic remedy is used to eliminate signs of neuroses. The medication contains quite dangerous components that cause addiction and negatively affect various organs (if the rules of administration are violated). To avoid adverse reactions, the drops are recommended to be used only for medical reasons, and the dosage should be strictly adhered to.

This information cannot be used for self-medication!

Consultation with a specialist is required!

Corvalol drops belong to a group of drugs that have antispasmodic and sedative effects, and also make it easier to fall asleep. This is a combination drug, its overall effect is due to the combination of substances included in the drug. The drug is sold without a prescription, available in the form of drops for internal use, available in glass bottles of 25 or 15 ml.

The composition of the drops per 1 ml includes 20 mg of ethyl ether, 1.42 mg of peppermint oil, 3.15 mg of sodium hydroxide, 18.26 mg of phenobarbital, 0.58 ml of the highest purity rectified alcohol and 0.42 ml of purified water . Peppermint relieves spasms, dilates blood vessels, phenobarbital can gently soothe, it is also a sleeping pill. The components help reduce the resulting excitement of the nervous system and help you fall asleep.

Corvalol drops are prescribed to obtain a sedative and vasodilating effect in cases of cardiovascular system disorders, sleep disturbances, neuroses with increased irritability, tachycardia, and agitation accompanied by vegetative manifestations. Drops are also effective for intestinal spasms.

Take the drug in the following dosage: 15–30 drops before meals three times a day. If an attack of tachycardia occurs, the dose is increased to 40–50 drops. As for children, they are given 3–15 drops, based on the age of the child, dividing them into two or three times. The optimal course of treatment will last as many weeks as the doctor says - treatment is individual.

Usually Corvalol is well tolerated by patients, only occasionally daytime drowsiness and mild attacks of dizziness occur. If the drug is taken for a long time, depression, rhinitis, apathy, hemorrhagic diathesis, conjunctivitis, or even impaired coordination of movements in the patient may develop.

Contraindications: renal, liver failure, hypersensitivity to the components of the drug, lactation period. Take with caution throughout pregnancy, the decision is made by the attending physician.

Store the medicine for up to 1.5 years in a dark place, away from children. The air temperature should not exceed 15 degrees.

Reviews about “Corvalol (drops)” from doctors and patients:

Previously, there was opium for the people, now it is Corvalol. Let me explain by analogy. Truly massive and extremely popular Corvalol was invented in Germany (more precisely, its almost complete analogue is Valocordin). They filmed the post-war depression in the 50s. last century.

Why do I care? Yes, because my elderly relatives drink Corvalol and everyone considers it harmless drops. Well, who doesn’t know Corvalol, its smell, taste? Meanwhile, not a single normal study has been conducted in our country on the effect of this drug on the health of older people. It is known that rats treated with phenobarbital throughout their lives died from cancer. Symptoms of chronic intoxication are also known: drowsiness, irritability, weakness, confusion, hallucinations, convulsions, imbalance, as well as changes in the functioning of the cardiovascular, digestive and urinary systems.

Now think about why your grandmother developed dementia (senile dementia) so early, and why your grandfather died of cancer.

Corvalol: instructions for use

Application of Corvalol

Corvalol is a combination drug that contains phenobarbital, peppermint oil, water, ethyl alcohol and ethyl ether. Thanks to phenobarbital, which has a vasodilating effect, peppermint oil acts more effectively, reducing spasm and dilating blood vessels. When the dose is increased, Corvalol acts as a hypnotic. The drug is used for neuroses of various origins with heart pain and increased irritability, angina pectoris, intestinal spasms, rapid heartbeat, hypertension. Corvalol is well tolerated and may only occasionally cause mild dizziness and drowsiness.

Corvalol drops: dosage

As such, there is no dosage of Corvalol. In the form of drops, the drug is available in 25 ml bottles. They should be taken before meals three times a day, 15-20 drops dissolved in a small amount of water. If necessary, the dose can be increased to 30. In case of an acute attack of tachycardia and severe pain in the chest area, you can drink 40-50 drops. Children can be given from 3 to 15 drops per day. You should not increase the dose on your own or experiment with this drug, as it can cause an overdose. Symptoms of overdose are memory impairment, impaired motor coordination, and the development of a depressed state. In this case, it is necessary to reduce the dose or stop taking the medicine altogether.

Is Corvalol prohibited? Can I take it?

For most people, Corvalol is considered a cure-all, but in fact it cannot be considered useful in the treatment of cardiovascular diseases. Its only effect is to dilate blood vessels and have a calming effect. Corvalol relieves certain symptoms that are caused by stress, not disease. The components of the drug (ethyl bromizovalerate, ethyl alcohol, phenobarbital) accumulate in the body and cause poisoning of internal organs. With long-term use, psychological and physiological dependence is formed (due to phenobarbital, a psychotropic substance that causes depression of the central nervous system and is a hard drug), which leads to poor sleep, anxiety, depression, and memory impairment. In many countries, Corvalol is prohibited, but in Russia it is sold only by prescription. So before taking this drug, think about whether you want to die from it?

Corvalol

Corvalol belongs to the group of sedatives. It contains phenobarbital, which is a psychotropic drug, isovaleric acid ester and peppermint leaf oil. Due to the last component, not only the specific smell of Corvalol is provided, but also a reflex antispasmodic and vasodilating effect. A derivative obtained from valerian roots has a calming effect on the nervous system, and in large doses causes drowsiness. Thus, the effect of Corvalol is due to its composition, which, in addition to the listed components, includes ethyl alcohol, sodium hydroxide and water.

Previously, there was only liquid Corvalol, drops of which had to be diluted with a certain volume of water. Currently, for the convenience of patients, Corvalol is produced in tablets for sublingual use.

Corvalol tablets are easy to use

It is interesting that this drug is distributed mainly in the Balkan Peninsula and in Russia. In other countries, they use a medicine that has a similar composition (valocordin). Phenobarbital, which is part of both drugs, is considered a drug in some countries (USA, Lithuania) and is prohibited for import.

Indications for use

The use of Corvalol is indicated for the following conditions:

changes in the function of the cardiovascular system associated with impaired neurohumoral regulation;
in complex therapy of neuroses, as well as with increased excitability and irritability;
for taking the drug Corvalol, indications include difficulty falling asleep due to increased anxiety;
tachycardia. associated with the influence of the sympathetic nervous system;
early stages of hypertension and minor spasm of the coronary arteries;
increased tone of the autonomic nervous system, accompanied by excitement;
spasms and increased peristalsis of the gastrointestinal tract.

How many drops of Corvalol to take in a given case is determined by the doctor, but the average dosage is 20-40 drops three times a day.

Contraindications

Contraindications for taking Corvalol are individual allergic reactions and intolerance to the components of the drug, as well as severe somatic diseases accompanied by severe renal or liver failure.

The calming effect of Corvalol has a beneficial effect on the cardiovascular system

Overdose

If an acute overdose of Corvalol occurs, intestinal motility slows down, and this leads to constipation.

With long-term use of the drug, chronic bromine poisoning is possible, which is manifested by depression and apathy, as well as damage to the mucous membranes (rhinitis, conjunctivitis), blood vessels (hemorrhagic diathesis) and the central nervous system (impaired speech, memory, attention, unsteadiness of gait). Libido often decreases and impotence develops.

Side effects

Side effects usually do not occur with the correct dosage of the drug. However, dizziness and daytime drowsiness may sometimes occur. In some cases, drug dependence develops, and when it is discontinued, abstinence occurs.

Corvalol and alcohol

This drug is often used to eliminate symptoms that occur after drinking large amounts of alcohol (hangover). These include increased heart rate. increased blood pressure, increased excitability. Due to the fact that Corvalol and alcohol have a sedative effect, when used together, an overdose and various side effects may develop.

Corvalol during pregnancy

Corvalol can be used during pregnancy, as well as during breastfeeding, only under strict indications. That is, if the expected benefit exceeds the harm that is likely to be caused to the child. This is due to the fact that phenobarbital, which is part of this medicine, can negatively affect the condition and development of the baby’s central nervous system, and also lead to intrauterine hypoxia.

Corvalol for children

Corvalol can be prescribed to children in special situations, and the dose should be reduced depending on age (one drop per one year of life). Interestingly, some doctors prescribe its use almost from birth, while others do not recommend taking it before 12 years of age. Since there is no consensus on this matter, it is worth listening to the opinion of your doctor, since only he has sufficient information about the child.

Corvalol is an indispensable drug in some situations when it is necessary to eliminate the symptoms of severe shock or dysfunction of the nervous system. It is also suitable as a temporary measure for tachycardia and hypertension. However, with long-term use, Corvalol often causes addiction and the development of side effects. Therefore, you should not self-medicate, but rather seek help from a specialist.

*registered by the Ministry of Health of the Russian Federation (according to grls.rosminzdrav.ru)

Registration number:

LP 003225-290915

Trade name of the drug:

Corvalol

International nonproprietary or generic name:

Peppermint Leaf Oil + Phenobarbital + Ethyl Bromoisovalerianate

Dosage form:

pills

Composition per tablet:

Active substances: ethyl bromizovalerianate (ethyl ester of alpha-bromoisovaleric acid) – 8.20 mg, phenobarbital – 7.50 mg, peppermint leaf oil (peppermint oil) – 0.58 mg.
Excipients: betadex (beta-cyclodextrin) – 55.55 mg, potato starch – 37.57 mg, lactose monohydrate (milk sugar) – 83.70 mg, magnesium aluminum metasilicate (neusilin UFL 2) – 4.00 mg, talc – 2.00 mg, magnesium stearate – 0.90 mg.

Description: Round, flat-cylindrical tablets of white or almost white color, interspersed, with a chamfer and a score.

Pharmacotherapeutic group:

sedative.

ATX code: .

Pharmacological properties

Pharmacodynamics
The combined drug has a sedative and antispasmodic effect, facilitating the onset of natural sleep.
Ethyl bromizovalerianate has a sedative and antispasmodic effect due to irritation, mainly of the receptors of the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and increased inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and a direct local antispasmodic effect on smooth muscles.
Phenobarbital has a sedative (in small doses), hypnotic, muscle relaxant and antispasmodic effects, helps reduce excitation of the central nervous system (CNS) and facilitates the onset of sleep, enhances the sedative effect of other components.
Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate “cold” receptors of the oral mucosa and reflexively dilate mainly the vessels of the heart and brain. Eliminates flatulence by irritating receptors in the mucous membrane of the gastrointestinal tract (GIT), enhancing intestinal motility.

Pharmacokinetics
Data on the pharmacokinetics of ethyl bromoisovalerate and the components of peppermint are not available.
When taken orally, phenobarbital is absorbed slowly and completely. The maximum concentration in the blood plasma is determined after 1-2 hours, the connection with plasma proteins is 50%, in newborns - 30-40%. Metabolized in the liver, induces microsomal liver enzymes with isoenzymes CYP3A4, CYP3A5, CYP3A7 (the rate of enzymatic reactions increases 10-12 times). Cumulates in the body. The half-life is 2-4 days. It is excreted by the kidneys in the form of glucuronide, about 25% unchanged. Penetrates into breast milk and through the placental barrier.

Indications for use

As a symptomatic (sedative and vasodilator) agent for functional disorders of the cardiovascular system, for neurosis-like conditions accompanied by increased irritability, for difficulty falling asleep, tachycardia, a state of agitation with pronounced vegetative manifestations; as an antispasmodic - for intestinal spasms.

Contraindications

Hypersensitivity to the components of the drug;
- severe renal and/or liver dysfunction;
- pregnancy;
- period of breastfeeding;
- children under 18 years of age (efficacy and safety have not been established);
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption (the drug contains lactose).

Carefully

Impaired liver and/or kidney function.
If you have one of the listed diseases/conditions, be sure to consult your doctor before taking the drug.

Use during pregnancy and breastfeeding

The use of the drug Corvalol during pregnancy and breastfeeding is contraindicated, since the drug contains phenobarbital, which penetrates the placenta and has a teratogenic effect, has a negative effect on the formation and further functioning of the central nervous system of the fetus and newborn; penetrates into breast milk, the development of physical dependence in the newborn is possible. If it is necessary to use it during breastfeeding, the issue of stopping breastfeeding should be decided.

Directions for use and doses

Take orally, before meals, with water.
The dosage is determined individually.
Adults are usually prescribed 1-2 tablets 2 times a day. For tachycardia, it is possible to increase the single dose to 3 tablets.
The duration of use of the drug is determined by the doctor individually.

Side effect

Drowsiness, dizziness, slow heart rate, decreased ability to concentrate, allergic reactions. Gastrointestinal disturbances may occur. These phenomena disappear when the dose of the drug is reduced or the drug is stopped.
With prolonged use of the drug, drug dependence, addiction, withdrawal syndrome may occur, as well as the accumulation of bromine in the body and the development of bromism phenomena (depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: depression of the central nervous system (CNS), nystagmus, ataxia, decreased blood pressure, agitation, dizziness, weakness, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).
Treatment: stopping the drug, gastric lavage and symptomatic therapy; if the central nervous system is depressed - caffeine, niketamide.

Interaction with other drugs

Medicines that depress the central nervous system enhance the effect of the drug. Phenobarbital (an inducer of microsomal oxidation) may reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives); enhances the effect of local anesthetics, analgesics and hypnotics.
The drug increases the toxicity of methotrexate.
The effect of the drug is enhanced by the use of valproic acid drugs.

special instructions

There is no experience with the use of the drug in children under 18 years of age.
You should not drink alcohol while using the drug.

Impact on the ability to drive vehicles and machinery

The drug contains phenobarbital, therefore patients taking Corvalol are advised to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles and working with complex mechanisms).

Release form

Pills.
10 tablets in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil.
1, 2, 3, 4 or 5 contour packages along with instructions for use are placed in a cardboard pack.

Storage conditions

Store the drug in its original packaging. At a temperature not higher than 25 °C.
Keep out of the reach of children!

Best before date

1 year 6 months. Do not use after the expiration date.

Vacation conditions

Available without a prescription.

Name and address of the manufacturer/organization accepting the complaint

OJSC Pharmstandard-Leksrsdstva.
305022, Russia, Kursk, st. 2nd Aggregatnaya, 1 a/18,
www.pharmstd.ru

Corvalol is used in the following cases:

insomnia and neuroses with high irritability;
in the complex of hypertension and vegetative-vascular dystonia;
with mild spasms of the coronary vessels;
in case of tachycardia;
as an antispasmodic drug to relieve intestinal spasms caused by neurovegetative disorders.

How to use

For adults, the drug Corvalol is prescribed orally or sublingually, 1 tablet or diluted with water, 10-30 drops. Can be consumed on a piece of sugar 2 or 3 times a day.

The drug is taken as needed, for example, during tachycardia and during spasms of the coronary vessels. A single dose can be increased to 3 tablets or 45–50 drops.

The period of use of Corvalol is determined by the doctor, based on the clinical effect and individual tolerance to the drug (Reviews of Corvalol can be read at the end of the article).

Release form. Compound

Corvalol is available in the form of tablets No. 10, 30, 50 pcs.

Composition of tablets:

ethyl ester of alphabromisiovaleric acid - 12.42 mg;
phenobarbital - 11.34 mg;
mint oil - 0.88 mg.

Corvalol is also produced in the form of drops:

d/oral. approx. fl. 25 ml, in a pack, No. 1
d/oral. approx. fl. 50 ml, in a pack, No. 1

Composition of drops:

alpha-bromisiovaleric acid ethyl ester - 2%;
phenobarbital - 1.82%;
peppermint oil - 0.14%.

Auxiliary components:

sodium hydroxide;
ethyl alcohol 90%;
distilled water.

Beneficial features

Corvalol is a sedative and antispasmodic drug, the effect of which is determined by the components it contains.

Ethyl ester of α-bromoisovaleric acid is characterized by a reflex-calming and antispasmodic effect on the body, caused by irritation of receptors in the oral cavity and nasopharynx, as well as a decrease in excitability in the central nervous system. In this case, the phenomena of inhibition in the brain are enhanced, and the activity of the vasomotor centers and a direct local antispasmodic effect on the smooth muscles of all vessels are reduced.
The phenobarbital component is able to reduce the flow of excitation to the cerebral cortex and subcortical structures. Depending on the dose, a decrease in the activating effect has a hypnotic, sedative and tranquilizing effect.
Corvalol reduces the stimulating effect on the vasomotor centers, peripheral and coronary vessels, lowering overall blood pressure, thereby relieving and preventing spasm of blood vessels, especially cardiac ones.
Peppermint oil contains many essential oils: about 50% menthol and 5-9% esters. They irritate the “cold” receptors of the oral cavity and reflexively dilate the vessels of the brain and heart, eliminating spasm of smooth muscles. Able to cause a sedative and weak choleretic effect. Peppermint oil also has an antispasmodic and antiseptic effect, and also has the ability to eliminate the phenomenon of flatulence.

When taking Corvalol sublingually, its absorption begins in the sublingual area. The bioavailability of active substances is high - up to 80%. The positive effect appears almost immediately.

The effect of the drug when taken orally develops within 10–30 minutes and lasts up to 6 hours. For those who have previously taken barbituric acid preparations, the duration of action becomes shorter due to an increase in the rate of phenobarbital metabolism in the liver.

In elderly people and patients with liver cirrhosis, the metabolic function of Corvalol is reduced, so T ½ becomes longer, which requires a dose reduction and an increase in the time interval between taking the drug.

Video

Watch the video below about the drug Corvalol:

Side effects

In most cases, the medicine is well tolerated. In rare cases, the following side effects may occur:

All these phenomena are gradually eliminated as the dosage of the drug is reduced. Dependence on Corvalol is possible in case of prolonged use, and bromism phenomena are also possible. The main symptoms include: apathy, depression, rhinitis, depression of the central nervous system, conjunctivitis, poor coordination, acne, confusion, hemorrhagic diathesis.

Contraindications

high sensitivity to the constituent components of the drug, as well as bromine;
dysfunction of the liver and kidneys;
hepatic porphyria;
severe heart failure;
the period of bearing a child and breastfeeding.

The drug should not be taken when operating machinery or driving vehicles.

There is no experience with the use of Corvalol in childhood.

Interaction with other drugs

drugs with central inhibitory action enhance the effect of Corvalol;
phenobarbital may have an inducing effect on liver enzymes, so its simultaneous use with drugs metabolized in the liver (oral contraceptives, griseofulvin, drugs with coumarin derivatives, corticosteroids) is not recommended;
Corvalol can enhance the effect of local anesthetics, hypnotics and painkillers (this is due to the barbituric acid derivatives it contains);
in combination with valproic acid, its effect is enhanced;
along with methotrexate, its toxicity increases;
alcohol increases the toxicity of the drug and enhances the effect.

Overdose

Overdose is possible in case of frequent and long-term use of the drug, which is associated with the process of cumulation of its components. Quite a long and constant use can provoke dependence, psychomotor agitation and withdrawal symptoms. Abrupt refusal to take Corvalol can provoke withdrawal syndrome.