Mexiprim how many courses per year. Mexiprim: instructions for use and what it is needed for, price, reviews, analogues

By medical classification Mexiprim is an antioxidant drug, active component which is ethylmethylhydroxypyridine succinate. The drug Mexiprim is produced by the Russian Obninsk chemical and pharmaceutical company. From the instructions for use you can learn about side effects, method of use, and drug interactions.

Composition and release form

Mexiprim is presented in tablet and solution format. Their differences in composition, packaging, concentration active ingredient:

	Pills
Description	Round white tablets with a creamy tint, coated film-coated, grayish-yellow inside	Yellowish clear liquid
Concentration of ethylmethylhydroxypyridine succinate, mg		100 or 250 per ampoule
Auxiliary components	Talc, kaolin, titanium dioxide, sodium carboxymethyl starch, macrogol, microcrystalline cellulose, hypromellose, polyvinyl chloride povidone, calcium stearate
Package	Packages of 10 pcs., packs with instructions	Ampoules of 2 or 5 ml, 5 pcs. in a package with scarifiers

Pharmacodynamics and pharmacokinetics

The antioxidant drug exhibits broad action, increases the body's resistance to stress, exhibits anxiolytic activity, and does not cause muscle relaxation. Mexiprim has a nootropic effect, reduces the risk of learning and memorization disorders, and prevents the development of senile pathologies. The drug has an anticonvulsant effect, antioxidant and antihypoxic properties, the ability to increase concentration, performance, and reduce toxic effect alcohol.

The medication increases the metabolic rate of brain tissue. Taking Mexiprim can lead to stabilization of the membrane structures of erythrocytes and platelets; it exhibits hypolipidemic properties in relation to adenylate cyclase and acetylcholinesterase, phosphodiesterase. The active ingredient Mexiprim is able to increase the content of dopamine in the brain, enhance the compensatory activity of aerobic glycolysis and reduce the inhibition of oxidation processes in the Krebs cycle under hypoxic conditions.

The principle of operation of the drug is to suppress lipid peroxidation, increase the activity of superoxide oxidase, the ratio of lipids and proteins, and lowers the level of cholesterol and low-density lipoproteins. Due to this, the viscosity of the membrane decreases and its fluidity increases. The drug is able to modulate the activity of membrane-bound enzymes (superoxide oxidase) and receptor complexes. This leads to improved transmission between synapses and a reduction in hypoxia.

The active component stabilizes cell membranes mitochondria. After oral administration, ethylmethylhydroxypyridine succinate is absorbed from the stomach and reaches its maximum concentration after half an hour. Metabolism of the drug occurs in the liver under the influence of creatine phosphate; glucurone conjugates are formed in the plasma. The half-life of metabolites is 4-5 hours. The substance is excreted in the urine.

Indications for use of Mexiprim

The instructions for use of the product indicate the indications. These are:

vegetative-vascular dystonia;
anxiety disorders, neurotic, neurosis-like conditions;
intoxication, senile and atrophic processes, neuroinfections, traumatic brain injuries;
mild cognitive disorders, psychoorganic syndrome, asthenic disorders, acute and chronic disorders cerebral circulation;
the impact of extreme stress factors on the brain;
alcohol withdrawal syndrome with a predominance of vegetative-vascular disorders.

How to take Mexiprim

Instructions for use of Mexiprim indicate the characteristics of administration depending on the form of release of the drug. Yes, the pills are taken orally, the solution is intended for parenteral administration. The dosage of both forms depends on the type of disease, its severity, individual characteristics patient. The dose and course of treatment are prescribed by a doctor.

The initial dose of Mexiprim, according to the instructions, is 250–500 mg per day, the maximum daily dosage is 800 mg. The dose is divided into 2-3 doses. Course of treatment for anxiety disorders, VSD ( vegetative-vascular dystonia) and cognitive impairment is 2–6 weeks, in the treatment of withdrawal syndrome in alcoholism – 5–7 days. The course of therapy ends gradually, with a dose reduction over 2-3 days.

Mexiprim solution

Mexiprim solution is intended for intramuscular or intravenous jet or drip administration. According to the instructions, before infusion, the injection drug is diluted in saline solution (0.9% sodium chloride solution). The initial dose of the drug is 50–100 mg 1–3 times a day, the maximum daily dosage equal to 800 mg. The jet injection of the solution should occur slowly, the time is 5–7 minutes, with drip injection the speed is 40–60 drops per minute.

According to the instructions, when complex therapy acute disturbance of cerebral blood flow, an intravenous drip of a solution is prescribed at a dose of 200–300 mg once a day for 2–4 days, then intramuscularly at a dose of 100 mg three times a day. Treatment lasts 10–14 days. For dyscirculatory encephalopathy in the stage of decompensation, Mexiprim is prescribed 100 mg 2-3 times a day for a course of 2 weeks. Course prophylaxis of this disease consists of intramuscular administration of a solution of 100 mg twice a day for a course of 10-14 days.

For cognitive impairment in elderly patients or anxiety states the medication is prescribed for intramuscular injection V daily dose 100-300 mg course of 0.5-1 month. At alcohol syndrome Mexiprim is administered in a dose of 100-200 mg 2-3 times a day intramuscularly or intravenously 1-2 times a day for a course of 5-7 days. Acute intoxication with antipsychotics is eliminated intravenous administration solution 50-300 mg per day for a course of 1-2 weeks.

special instructions

During therapy, the patient may experience dizziness and drowsiness, which precludes the possibility of using the drug when driving or driving. dangerous mechanisms. The use of tablets or the administration of a solution can reduce concentration and reduce the speed of psychomotor reactions. There are no other special instructions for the use of the drug in the instructions.

During pregnancy

To date, the effectiveness and safety of using Mexiprim during pregnancy and breastfeeding have not been fully studied. In this regard, the use or use of the drug while pregnant and during lactation is contraindicated according to the instructions. You should not prescribe the drug yourself; this should only be done by your doctor.

In childhood

According to the instructions, adequate and strictly regulated by law studies of the safety and effectiveness of the use of the drug Mexiprim in children have not been conducted. Because of this, the medication should not be used in patients with this age category(under 18 years old). This may lead to negative consequences And negative influence on the growth and development of the child.

Drug interactions

According to the instructions, Mexiprim is able to reduce toxic effect ethyl alcohol, so it can be used to eliminate the consequences of alcoholism. Simultaneous use a drug with anxiolytics, benzodiazepines, levodopa, antiparkinsonian drugs, carbamazepine, anticonvulsants, neurotransmitters enhances their effect. It is allowed to combine the medicine with psychotropic drugs, this does not affect their excretion.

Side effects of Mexiprim

The instructions for use of Mexiprim note that side effects during its use are observed extremely rarely. The most common are nausea, dry mouth, drowsiness, allergies ( skin rash, itching, urticaria, dermatitis, peeling of the skin). They go away on their own and do not require a prescription. special treatment.

Overdose

Signs of an overdose of Mexiprim, according to these instructions, are drowsiness, insomnia and other sleep disorders. Symptoms resolve without intervention within a day. If the symptoms are complicated, then for insomnia you can take 10 mg of Nitrazepam or Oxazepam, or 5 mg of Diazepam. Before using these medications, obtain the advice and approval of your physician.

Contraindications

The instructions pages contain contraindications for the use of Mexiprim tablets and solution. These include conditions and diseases:

renal, liver failure (acute stages diseases);
pregnancy;
children's and adolescence up to 18 years old;
breast-feeding;
increased sensitivity to the components of the composition.

Terms of sale and storage

Mexiprim can be purchased upon presentation of a prescription from a doctor. Tablets are stored at temperatures up to 30 degrees for five years, solution - at 25 degrees for three years.

Analogues

There are analogues of Mexiprim, similar to it in action and content of the active component. Drug substitutes include:

Astrox is an antihypoxic solution from the class of 3-hydroxypyridines;
Medomexi – stress-protective tablets and solution;
Mexidant – antioxidant solution;
Mexidol - injections and tablets with antioxidant action;
Mexicor - capsules and ampoules with a solution with neuroprotective properties;
Mexifin – anticonvulsant solution;
Metostabil - tablets with nootropic action;
Neurox – antioxidant solution, inhibitor free radicals;
Cerecard is an antiepileptic solution.

Mexiprim price

You can buy Mexiprim online or at a pharmacy. Its cost depends on the network markup, type of release and concentration of the active substance. Approximate Moscow prices.

In this article we will look at the instructions for use for the drug “Mexiprim”.

It is a drug that has a pronounced antioxidant effect. Against the background of its use, the body's resistance to stress and its resistance to physical stress increases. The drug is able to provide parts of the brain suffering from a lack of oxygen by restoring blood supply. As a result, the patient experiences an increase in the ability to perceive information, concentrate, and memory improves. In addition, the drug has the ability to reduce cholesterol levels in the blood.

Analogues of Mexiprim are not listed in the instructions for use; we will consider them below.

Pharmacological forms

Manufacturers produce the drug in two pharmacological forms:

Mexiprim tablets.
A solution intended for intravenous administration.

Composition, description

According to the instructions for Mexiprim, its solution is transparent, yellowish or white shade. The main active component in its composition is ethylmethylhydroxypyridine succinate in an amount of 50 mg. Additional component purified water comes out.

Tablet "Mexiprim" contains 125 mg of the active ingredient. The following auxiliary ingredients are used: microcrystalline cellulose, povidone, sodium carboxymethyl starch, talc, calcium stearate, kaolin. The tablets are film-coated made of hypromellose, titanium dioxide, macrogol and talc.

Pharmacological group

As the instructions indicate, Mexiprim is a heteroaromatic antioxidant. The medicine has a wide medicinal activity: capable of exhibiting anxiolytic effects, which are not accompanied by a muscle relaxation effect. Against the background of his reception:

Decreasing toxic effects alcohol.
The body's performance and ability to concentrate increases.
Antihypoxic and antioxidant function appears.
An anticonvulsant effect occurs.
The ability to absorb information increases.
The likelihood of developing memory impairment is reduced.
Developing nootropic effect.
The body's ability to withstand stress increases.

The active components are able to increase dopamine levels, increase aerobic glycolysis, and reduce the inhibition of oxidative processes in the Krebs cycle.

Indications for use

Acute intoxication with antipsychotic drugs.
Withdrawal syndrome, accompanying alcohol addiction.
Severe anxiety syndrome.
Neurosis-like states, neuroses.
Cognitive disorders accompanying atherosclerosis.
Encephalopathy.
Acute disturbances of natural blood circulation in the brain.

Clinical studies on the possibility of using the drug in the treatment of patients childhood were not carried out. Reliable data showing the mechanism of action of the main component of the drug on children's body, is currently not available, and therefore the use of the drug by patients of this age category is prohibited.

Use is strictly prohibited medicinal product pregnant and lactating women. Clinical studies of the effect of the active component on fetal development have not been conducted. If there is a need for a nursing woman to use the product, the child should first be switched to artificial feeding.

The instructions for Mexiprim are very detailed.

Contraindications for use

The medication should not be used if the patient has the following disorders and physiological conditions:

Childhood.
Pregnancy.
Lactation.
Individual hypersensitivity to the components of the drug.

Caution should be exercised when prescribing the drug to patients with impaired liver and kidney function.

Usage

In accordance with the instructions for use for Mexiprim, the tablet drug should be taken orally. Take the tablets with plenty of water.

When treating adult patients, the use of two tablets per day is indicated. If the expected therapeutic effect is absent, the dose may be increased up to 800 mg per day. It is recommended to divide the maximum daily dose into 4 doses.

The optimal duration is considered to be a course of therapy of 2 months, but it may vary depending on the indications and recommendations of a specialist.

Its use during pregnancy can provoke disruption of the natural development of the fetus. The drug is also prohibited for use during lactation.

Instructions for use for Mexiprim must be strictly followed.

Negative Impacts

If the patient complies with the dosage and dosage regimens recommended by the doctor, then the likelihood of developing negative impacts extremely low. If there is an individual susceptibility to active substance such unwanted effects, How:

Swelling skin.
Redness of the skin.
Hives.
Depression.
Apathy.
Lethargy.
Quincke's edema (extremely in rare cases).
Drowsiness.
Decreased appetite or its complete absence.
Abdominal pain.
Flatulence.
Nausea.
Dryness of the mucous membranes in the oral cavity.

This is confirmed by the instructions for use and reviews of the drug “Mexiprim”. When any of the indicated or unmarked negative symptoms the patient should inform the doctor about this.

Interaction with other medications

As the instructions for use for Mexiprim tell us, it can be used in parallel with psychotropic drugs. The medication can increase the therapeutic effect sedatives, which requires adjustment of the doses of the latter.

Special instructions for use

The use of Mexiprim for the treatment of pediatric patients is strictly prohibited. It should not be used when treating adolescents. During pregnancy, it is recommended to refrain from taking this medication. This is due, first of all, to the fact that the mechanism of influence of the active component in the composition of the drug has not been fully studied. It is assumed that the medicine can influence the speed of psychomotor reactions, and therefore it is recommended to completely abandon or significantly limit activities related to driving vehicles and complex mechanisms.

What else can you learn from the instructions for use of Mexiprim?

Overdose

If the patient uses the drug in strict accordance with the specialist’s recommendations, then the likelihood of overdose is extremely low. If an overdose does occur, it is expressed in increased negative effects. The main manifestation of an overdose of Mexiprim is severe drowsiness. To eliminate such manifestations, it is necessary to perform gastric lavage on the patient and stop using the medication. In this case, these symptoms disappear within 24 hours. If indigestion occurs, symptomatic therapy should be prescribed.

This is what it says in the instructions for the Mexiprim tablets.

Terms of sale and storage

Medicine refers to prescription drugs. That is, to purchase it at a pharmacy you will have to present a prescription from a doctor. Mexiprim should be stored in a place that is protected from intrusion sun rays, A ambient temperature however, it should not exceed 30 degrees. It is important to prevent children from accessing the drug.

The maximum period during which the medicine retains its properties therapeutic properties- 4 years. If the drug has expired, its use becomes unacceptable.

We will not consider in detail the instructions for Mexiprim analogues.

Analogues

If necessary, the drug can be replaced similar means. The most popular drugs with similar action are:

"Cytoflavin". It is an analogue of Mexiprim in terms of pharmacological group. The manufacturer produces the drug in tablet and injection form. With the use of the drug, metabolism in brain tissue improves. Cytoflavin can be used in pediatrics, even when treating newborns, which is an undoubted advantage over Mexiprim.
"Ethoxidol." It is an analogue of Mexiprim in its therapeutic group and is an antioxidant. The manufacturer produces the medicine in the form of tablets intended for chewing. Often prescribed for encephalopathy, cognitive disorders, ischemic strokes, IBS.
"Mexi B6". It is a combination medication that contains pyridoxine in addition to ethylmethylhydroxypyridine succinate. These active components can enhance the effects of each other, which significantly expands the scope of the drug. For example, it is often used as prophylactic against attacks of ischemic heart disease.
"Mexidol". It is a reference drug of domestic production. The main active component, as in Mexiprim, is ethylmethylhydroxypyridine succinate. The medication has undergone extensive clinical trials, which have made it possible to accurately determine the likely therapeutic effect of its use, as well as negative reactions. As auxiliary components Mexidol uses substances different from Mexiprim.

Price

On average, one package of Mexiprim will cost 370 rubles. However, the cost may vary depending on pricing policy spreading it pharmacy chain, as well as the region of sale. Thus, the price of Mexiprim in some pharmacies can reach 1070 rubles.

This information is not contained in the instructions for use for Mexiprim tablets.

Compound :

active substance: 1 ml of the drug contains ethylmethylhydroxypyridine succinate 50 mg

Excipients: water for injections.

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Dosage form

Injection.

Basic physicochemical characteristics: clear, colorless or slightly yellowish liquid.

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Pharmacological group

Means affecting nervous system. ATX code N07XX.

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Pharmacological properties

Pharmacological.

Mexiprim ® is an inhibitor of free radical processes, a membrane protector, has an antihypoxic effect, stress-protective, nootropic, anticonvulsant and anxiolytic effect. The drug increases the body’s resistance to the effects of various damaging factors, acid pathological conditions(shock, hypoxia and ischemia, cerebrovascular accidents, alcohol intoxication and antipsychotics(neuroleptics).

The drug improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. Has a hypolipidemic effect, reduces the content total cholesterol and low-density lipoproteins (LDL). Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

The mechanism of action is due to its antioxidant and membrane protective effect. It inhibits lipid peroxidation, increases superoxide oxidase activity, increases the lipid-protein ratio, and reduces membrane viscosity. Modulates the activity of membrane-bound enzymes (calcium-dependent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, gamma-aminobutyric acid(GABA), acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexiprim ® increases the content of dopamine in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of adenosine triphosphate (ATP) and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

Mexiprim ® normalizes metabolic processes in ischemic myocardium, reduces the area of necrosis, restores and improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, reduces the consequences of reperfusion syndrome in acute coronary insufficiency. Increases the antianginal activity of nitro drugs. Mexiprim ® promotes the preservation of retinal ganglion cells and fibers optic nerve with progressive neuropathy, the consequences of which are chronic ischemia and hypoxia. Improves functional activity retina and optic nerve, increasing visual acuity.

Pharmacokinetics.

When administered, the drug is determined in the blood plasma within 4:00 after administration. The time to reach maximum concentration is 0.45-0.5 hours. The maximum concentration at doses of 400-500 mg is 3.5-4.0 mcg/ml. Mexiprim ® quickly goes from bloodstream into organs and tissues and is quickly eliminated from the body. It is excreted from the body in the urine, mainly in glucuron-conjugated form and in small quantities unchanged.

Indications

Acute cerebrovascular accidents
traumatic brain injury, consequences of traumatic brain injury;
encephalopathy
cardiopsychoneurosis;
mild cognitive disorders of atherosclerotic origin;
anxiety states in neurotic and neurosis-like conditions;
acute myocardial infarction (from the first day), as part of complex therapy
primary open-angle glaucoma of various stages, as part of complex therapy
relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;
acute intoxication with antipsychotic drugs;
acute purulent-inflammatory processes in abdominal cavity(acute necrotizing pancreatitis, peritonitis) as part of complex therapy.

Contraindications

Acute hepatic or renal failure, hypersensitivity to the drug.

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Interaction with other drugs and other types of interactions

Mexiprim ® enhances the effect of benzodiazepine anxiolytics, anticonvulsants(carbamazepine), antiparkinsonian drugs (levodopa). Potentiates the effect of nitromic drugs, antihypertensive drugs. Reduces the toxic effect of ethyl alcohol.

Features of application

In some cases, especially in predisposed patients, in patients with bronchial asthma with increased sensitivity to sulfites, severe hypersensitivity reactions may develop. It should be used with caution in patients with diabetic retinopathy (the course should not exceed 7-10 days) due to the property of enhancing proliferative processes.

After completion of parenteral administration, to maintain the achieved effect, it is recommended to continue using the drug orally in tablet form.

Use during pregnancy or breastfeeding

Strictly controlled clinical trials The safety of the drug during pregnancy and lactation has not been studied, therefore Mexiprim ® should not be used during this period.

The ability to influence the reaction rate when driving vehicles or other mechanisms

During the treatment period, care must be taken when driving vehicles or operating machinery, given the likelihood side effects, which can affect reaction speed and ability to concentrate.

Directions for use and doses .

Mexiprim ® is prescribed intramuscularly or intravenously (stream or drip). When administered by infusion, the drug should be diluted in saline solution sodium chloride (200 ml). Begin treatment for adults with a dose of 50-100 mg 1-3 times a day, gradually increasing the dose until therapeutic effect. Mexiprim ® should be administered in a stream slowly over 5-7 minutes, drip-wise at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 800 mg.

For acute cerebrovascular accidents Mexiprim® is prescribed as part of complex therapy in the first 2-4 days intravenously in adults at 200-300 mg once a day, then intramuscularly at 100 mg 3 times a day. The treatment period is 10-14 days.

For traumatic brain injury and consequences of traumatic brain injury Mexiprim® is used for 10-15 days by intravenous drip administration according to

200-500 mg 2-4 times a day.

For dyscirculatory encephalopathy in the decompensation phase, Mexiprim ® should be administered intravenously in a stream or drip at a dose of 100 mg 2-3 times a day for 14 days. Then the drug is administered intramuscularly at 100 mg per day for 2 weeks.

For a course of prophylaxis of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.

For mild cognitive impairment in elderly patients and anxiety states The drug is administered intramuscularly at a dose of 100-300 mg per day for 14-30 days.

At acute heart attack myocardium as part of complex therapy Mexiprim ® is administered intravenously or intramuscularly for 14 days, against the background traditional therapy myocardial infarction, including nitrates, beta blockers, ACE inhibitors(ACE), thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic remedies according to indications. In the first 5 days, to achieve maximum effect, it is desirable to administer Mexiprim ® , in the next 9 days intramuscular administration of Mexiprim ® is possible. Administration is carried out by drip infusion, slowly (to avoid side effects), with a 0.9% sodium chloride solution or a 5% glucose solution (glucose) in a volume of 100-150 ml for 30-90 minutes. If necessary, slow jet injection Mexiprim ® for at least 5 minutes.

Mexiprim ® is administered (intravenously or intramuscularly) 3 times a day, every 8:00. The daily therapeutic dose is 6-9 mg per kilogram of body weight per day, single dose- 2-3 mg/kg body weight. The maximum daily dose should not exceed 800 mg, a single dose - 250 mg.

For open-angle glaucoma different stages as part of complex therapy, Mexiprim ® is administered intramuscularly at 100-300 mg per day, 1-3 times a day for 14 days.

For alcohol withdrawal syndrome Mexiprim ® is administered in a dose of 100-200 mg 2-3 times a day or intravenously 1-2 times a day for 5-7 days.

At acute intoxication antipsychotics The drug is administered intravenously at a dose of 50-300 mg per day for 7-14 days.

In acute purulent-inflammatory processes of the abdominal cavity(acute necrotizing pancreatitis, peritonitis) the drug should be prescribed on the first day both preoperatively and during postoperative period. Doses depend on the form and severity of the disease, the prevalence of the process, variants clinical course. Discontinuation of the drug should be carried out gradually, only after a stable positive clinical and laboratory effect. For acute edematous (interstitial) pancreatitis, Mexiprim ® is prescribed 100 mg 3 times a day intravenously (in isotonic sodium chloride solution) and intramuscularly. Mild degree gravity necrotizing pancreatitis: 100-200 mg 3 times a day intravenously (in isotonic sodium chloride solution) and intramuscularly. Average degree gravity: 200 mg 3 times a day intravenously (in isotonic sodium chloride solution). Severe course: per pulse - dosage of 800 mg per day with double administration; then - 300 mg 2 times a day with gradual decline daily dose. Very severe course : in the initial dose - 800 mg per day until stable relief of the manifestations of pancreatogenic shock, after stabilization of the condition - 300-400 mg 2 times a day intravenously (in isotonic sodium chloride solution) with a gradual decrease in the daily dose.

Antioxidant drug

Active substance

Ethylmethylhydroxypyridine succinate

Release form, composition and packaging

2 ml - glass ampoules (5) - contour cell packaging (1) - cardboard packs.
2 ml - glass ampoules (5) - contour cell packaging (2) - cardboard packs.
2 ml - glass ampoules (5) - contour cell packaging (20) - cardboard boxes.
2 ml - glass ampoules (5) - contour cell packaging (50) - cardboard boxes.
2 ml - glass ampoules (5) - contour cell packaging (100) - cardboard boxes.

Solution for intravenous and intramuscular administration colorless or slightly yellowish, transparent.

Excipients: water for injection.

5 ml - glass ampoules (5) - contour cell packaging (1) - cardboard packs.
5 ml - glass ampoules (5) - contour cell packaging (2) - cardboard packs.
5 ml - glass ampoules (5) - contour cell packaging (20) - cardboard boxes.
5 ml - glass ampoules (5) - contour cell packaging (50) - cardboard boxes.
5 ml - glass ampoules (5) - contour cell packaging (100) - cardboard boxes.

pharmachologic effect

Antioxidant drug. It is an inhibitor of free radical processes, a membrane protector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The drug increases the body's resistance to the effects of various damaging factors (hypoxia and ischemia, cerebrovascular accidents, intoxication with alcohol and antipsychotic drugs).

The mechanism of action of Mexiprim is due to its antioxidant and membrane protective effect. It inhibits lipid peroxidation, increases superoxide oxidase activity, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Modulates the activity of membrane-bound
enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. increases dopamine levels in the brain. Causes an increase in compensatory activation of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions with an increase in the content of ATP and creatine phosphate, activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

The drug improves metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, and reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. It has a lipid-lowering effect, reduces the content of total cholesterol and LDL.

Pharmacokinetics

Suction

When Mexiprim is administered in doses of 400-500 mg, Cmax is 3.5-4.0 μg/ml and is achieved within 0.45-0.5 hours.

Distribution

It quickly passes from the bloodstream to organs and tissues. After intramuscular administration, the drug is determined in the blood plasma within 4 hours. The average retention time of the drug in the body is 0.7-1.3 hours.

Metabolism

Metabolized in the body by intensive conjugation with glucuronic acid.

Removal

It is quickly excreted from the body in the urine, mainly in glucurone-conjugated form and in small quantities unchanged.

Indications

- acute cerebrovascular accidents;

— vegetative-vascular dystonia;

— mild cognitive disorders of atherosclerotic origin;

- neuroses and neurosis-like conditions accompanied by anxiety syndrome;

— relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders;

- acute intoxication with antipsychotic drugs (neuroleptics).

Contraindications

- acute liver dysfunction;

- acute renal dysfunction;

- lactation (breastfeeding);

- hypersensitivity to the components of the drug.

Dosage

Mexiprim is administered intramuscularly or intravenously (stream or drip). To prepare a solution for infusion, the drug should be diluted with an isotonic solution.

Doses are selected individually depending on the pathology and severity of the patient's condition. The initial dose is 50-100 mg 1-3 times/day. In the future, it is possible to increase the dose until a therapeutic effect is obtained. The maximum daily dose is 800 mg.

Mexiprim is administered in a stream slowly over 5-7 minutes, dropwise at a rate of 40-60 drops/min.

During treatment acute disorders cerebral circulation Mexiprim is used in complex therapy in the first 2-4 days intravenously at a dose of 200-300 mg 1 time/day, then intramuscularly at 100 mg 3 times/day. The duration of treatment is 10-14 days.

At dyscirculatory encephalopathy in the decompensation phase, Mexiprim should be prescribed intravenously in a stream or drip at a dose of 100 mg 2-3 times a day for 14 days. Then the drug is administered intramuscularly at 100 mg/day over the next 2 weeks. For course prevention of dyscirculatory encephalopathy the drug is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.

At mild cognitive impairment in elderly patients and with anxiety disorders the drug is used intramuscularly in a daily dose of 100-300 mg for 14-30 days.

At alcohol withdrawal syndrome Mexiprim is administered in a dose of 100-200 mg IM 2-3 times a day or IV drip 1-2 times a day for 5-7 days.

At acute intoxication with antipsychotic drugs the drug is administered intravenously at a dose of 50-300 mg/day for 7-14 days.

Side effects

From the outside digestive system: nausea, dry mouth.

Others: drowsiness, allergic reactions.

Mexiprim is an antioxidant medicine. What is this remedy prescribed for? The drug has anxiolytic properties. Instructions for use recommend taking Mexiprim injections and tablets for neuroses, neurasthenia and other mental disorders.

Release forms and composition

Solution for intravenous and intramuscular administration (injections in injection ampoules).
Film-coated tablets 125 mg.

One milliliter of Mexiprim solution contains 50 grams of active medicinal compound, as well as about 1 milliliter of excipient - water for injection.

One film-coated tablet contains 0.125 grams of ethylmethylhydroxypyridine succinate, as well as excipients such as talc, kaolin, povidone, sodium carboxymethyl starch, calcium stearate and MCC.

Pharmacological properties

Since the instructions for use refer to the drug "Mexiprim" as an antioxidant of the heteroaromatic series, it differs wide range applications. The medicine increases the body's resistance to stressful situations. When using the drug, its anxiolytic properties appear, without muscle relaxant effects or drowsiness.

The medication reduces and prevents the occurrence of memory and learning disorders, and has a nootropic and anticonvulsant effect on elderly patients. Thanks to its antihypoxic and antioxidant properties, Mexiprim helps improve performance and concentration, and in addition, minimizes the harmful toxic effects of alcoholic beverages.

The tool provides positive impact on brain tissue, as well as circulatory system the body by stimulating blood microcirculation and platelet aggregation. The drug reduces cholesterol levels due to its pronounced lipid-lowering properties. When the drug enters the human body, it is quickly metabolized and transformed into glucurone-conjugated breakdown products.

Why is Mexiprim prescribed?

Indications for use include

exposure to stress (extreme) factors;
mild cognitive impairment of various origins(for asthenic disorders and psychoorganic syndrome, caused by chronic and acute circulatory disorders in the brain, traumatic brain injuries, atrophic and senile processes, intoxications and neuroinfections);
intellectual disability and memory disorders in older people;
vegetative-vascular dystonia;
anxiety states in neurosis-like and neurotic conditions;
withdrawal syndrome in alcoholism with a predominance of vegetative-vascular and neurosis-like disorders.

What else does Mexiprim help with? Additional indications for the use of the drug in solution form are:

acute intoxication with antipsychotic drugs;
acute cerebrovascular accidents (with combined treatment);
encephalopathy.

Instructions for use

Mexiprim tablets

Prescribed internally. Therapeutic dose and duration of treatment are determined by the patient's sensitivity to the drug.

At the beginning of treatment, the drug is prescribed in a dose of 250-500 mg, the average daily dose is 250-500 mg, the maximum daily dose is 800 mg. The daily dose is distributed into 2-3 doses during the day.

When relieving alcohol withdrawal syndrome, the duration of use is 5-7 days. For the treatment of anxiety disorders, vegetative-vascular dystonia and cognitive impairment, the drug is used for 2-6 weeks.

The course of therapy with Mexiprim is completed gradually, reducing the dose over 2-3 days.

Injections

"Mexiprim" in ampoules is administered intramuscularly or intravenously (stream or drip (in the form of a dropper)). To prepare a solution for infusion, the drug should be diluted with isotonic sodium chloride solution.

Doses are selected individually depending on the pathology and severity of the patient's condition. The initial dose is 50-100 mg 1-3 times a day. In the future, it is possible to increase the dose until a therapeutic effect is obtained. The maximum daily dose is 800 mg.

Mexiprim is administered in a stream slowly over 5-7 minutes, and dropwise at a rate of 40-60 drops/min.

In the treatment of acute cerebrovascular accidents, the drug is used in complex therapy in the first 2-4 days intravenously at a dose of 200-300 mg once a day, then intramuscularly at a dose of 100 mg 3 times a day. The duration of treatment is 10-14 days.

For dyscirculatory encephalopathy in the decompensation phase, Mexiprim should be prescribed intravenously in a stream or drip at a dose of 100 mg 2-3 times a day for 14 days. Then the drug is administered intramuscularly at 100 mg per day over the next 2 weeks. For a course of prophylaxis of dyscirculatory encephalopathy, the drug is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.

For alcohol withdrawal syndrome, Mexiprim is administered in a dose of 100-200 mg IM 2-3 times a day or IV drip 1-2 times a day for 5-7 days.

In case of acute intoxication with antipsychotic drugs, the drug is administered intravenously at a dose of 50-300 mg per day for 7-14 days.

For mild cognitive impairment in elderly patients and anxiety disorders, the drug is used intramuscularly in a daily dose of 100-300 mg for 14-30 days.

Contraindications

General contraindications for Mexiprim injections and tablets are:

pregnancy;
disorders of the liver or kidneys (acute stages of the disease);
lactation period;
hypersensitivity;
childhood.

Side effects

In rare cases, during therapy with Mexiprim, nausea, drowsiness, dryness of the oral mucosa, and hypersensitivity reactions may develop.

What are the analogues of the drug Mexiprim?

Complete analogues for the active element:

Medomexy.
Mexipridol.
Metostabil.
Mexican.
Ethylmethylhydroxypyridine succinate.
3-hydroxy-6-methyl-2-ethylpyridine succinate.
Mexidol injection solution 5%.
Mexicofin.
Mexidol.
Neurox.
Mexidant.
2-ethyl-6-methyl-3-hydroxypyridine succinate.
Cerecard.

Preducted.
Thiotriazolin.
Kudevita.
Sodium hydroxybutyrate.
Trimectal.
Glation.
Limontar.
Mitomin.
Triducard.
Yantavit.
Oxylic.
Metaguard.
Cardioxipin.
Dimephosphone.
Enerlit.
Rimekor.
Deprenorm MV.
Thiogamma.
Kudesan for children.
Laprote.
Antisthene.
Ethoxydol.
Angiosil retard.
Preductal MV.
Ethylthiobenzimidazole hydrobromide.
Solcoseryl.
Cytochrome C.
Trimetazidine.
Trekrezan.
Mexidol.
Histochrome.
Emoxipin.
Vitanam.
Valeocor Q10.
Proxipin.
Precard.
Actovegin.
Carnifit.
Phenosanic acid.
Levocarnitine.
Predisin.
Carnitine.
Olifen.
Kudesan.
Kudesan Forte.
Methylethylpyridinol.
Hypoxene.
Confumin.

Price and holiday conditions

The average price of Mexiprim in pharmacies (Moscow) is 166 rubles for 30 tablets of 125 mg. Injections cost 380 rubles for 10 ampoules of 2 ml. In Minsk and Kazakhstan, the medicine can be purchased to order. In Kyiv, the drug is sold for 126 hryvnia. Can be purchased with a prescription.