Syndrome of intracranial hypertension code microbial 10. Signs and methods of elimination of intracranial hypertension

RCHD (Republican Center for Health Development of the Ministry of Health of the Republic of Kazakhstan)
Version: Clinical Protocols of the Ministry of Health of the Republic of Kazakhstan - 2013

Hypertensive heart disease without (congestive) heart failure (I11.9)

general information

Short description

Protocol approved
Expert Commission on Health Development
June 28, 2013


Arterial hypertension- chronic stable increase in blood pressure, in which the level of systolic blood pressure is equal to or greater than 140 mm Hg and (or) the level of diastolic blood pressure is equal to or greater than 90 mm Hg in people who are not receiving antihypertensive drugs . [Recommendations of the World Health Organization and the International Society of Hypertension 1999]. Resistant arterial hypertension - exceeding the target level of blood pressure, despite treatment with three antihypertensive drugs, one of which is a diuretic.

I. INTRODUCTION

Name: arterial hypertension
Protocol code: I10

ICD codes - 10:
I 10 Essential (primary) hypertension;
I 11 Hypertensive heart disease (hypertension with a primary lesion of the heart);
I 12 Hypertensive (hypertonic) disease with a primary lesion of the kidneys;
I 13 Hypertensive (hypertonic) disease with a primary lesion of the heart and stoves.

Abbreviations used in the protocol:
AGP - antihypertensive drugs
AGT - antihypertensive therapy
BP - blood pressure
AK - calcium antagonists
ACS - associated clinical conditions
ALT - alanine aminotransferase
ASA - acetylsalicylic acid
ACT - aspartate aminotransferase
β-AB - β-blockers
ARBs - angiotensin 1 receptor blockers
GC - hypertensive crisis
LVH - left ventricular hypertrophy
DBP - diastolic blood pressure
DLP - dyslipidemia
ACE inhibitors - angiotensin-converting enzyme inhibitors
IHD - ischemic heart disease
MI - myocardial infarction
BMI - body mass index
ISAH - isolated systolic arterial hypertension
CT - computed tomography
LV - left ventricle
HDL - high density lipoproteins
LDL - low density lipoproteins
MAU - microalbuminuria
MDRD - Modification of Diet in Renal Disease
ICD - 10 - international classification of diseases ICD - 10
MRA - magnetic resonance angiography
MRI - magnetic resonance imaging
MS - metabolic syndrome
IGT - Impaired Glucose Tolerance
coolant - obesity
ACS - acute coronary syndrome
ONMK - acute disorders of cerebral circulation
OPSS - total peripheral vascular resistance
OT - waist size
THC - total cholesterol
POM - target organ damage
PHC - primary health care
SBP - systolic blood pressure
SCAD - Spontaneous Coronary Artery Dissection
DM - diabetes mellitus
GFR - glomerular filtration rate
ABPM - ambulatory blood pressure monitoring
CVD - cardiovascular diseases
SSO - cardiovascular complications
CCC - cardiovascular system
TG - triglycerides
TIA - transient ischemic attack
Ultrasound - ultrasonography
RF - risk factor
COPD - chronic obstructive pulmonary disease
CHS - cholesterol
CHF - chronic heart failure
HR - heart rate
ECG - electrocardiography
EchoCG - echocardiography

Protocol development date: 2013
Patient category: patients with essential and symptomatic arterial hypertension.
Protocol Users: general practitioners, therapists, cardiologists.

Classification

Clinical classification

Table 1 - Classification of blood pressure levels (mm Hg)

Categories DD GARDEN DBP
Optimal < 120 And <80
Normal 120 - 129 and/or 80-84
high normal
. AG 1 degree
. AG 2 degrees
. AG 3 degrees
130 - 139
140 - 159
160 - 179
≥ 190
and/or
and/or
and/or
and/or
85-89
90-99
100-109
≥110
Isolated systolic hypertension* ≥ 140 And <90

Note: * ISAH should be classified into 1, 2, 3 degrees according to the level of SBP.

Table 2 - Criteria for risk stratification (factors affecting the prognosis)

Risk factors

Significance of SBP and DBP
- The level of pulse blood pressure (in the elderly).
- Age (men>55 years, women>65 years)
- smoking
- Dyslipidemia: total cholesterol >5.0 mmol/l (>190 mg/dl), or LDL cholesterol >3.0 mmol/l (>115 mg/dl), or HDL cholesterol in men<1,0 ммоль/л (40 мг/дл), у женщин <1,2 ммоль/л (4 мг/дл), или ТГ >1.7 mmol/l (>150 mg/dl)
- Fasting plasma glycemia 5.6-6.9 mmol/l (102-125 mg/dl)
- Impaired glucose tolerance
- Abdominal obesity: waist circumference in men ≥102 cm, in women ≥88 cm
- Family history of early cardiovascular disease (in women under 65 years of age, in men under 55 years of age). The combination of 3 of the following 5 criteria indicates the presence of metabolic syndrome: abdominal obesity, change in fasting glycemia, BP> 130/85 mmHg, low HDL-C, high TG.

Asymptomatic target organ damage

ECG signs of LVH (Sokolov-Lyon index >38 mm, Cornell index >2440 mm x ms) or:
- Echocardiographic signs of LVH* (LV mass index >125 g/m 2 in men and >110 g/m 2 in women)
- Thickening of the carotid artery wall (intima-media complex >0.9 mm) or presence of atherosclerotic plaque
- Velocity of the carogid-femoral pulse wave >12 m/s
- Slight increase in serum creatinine: up to 115-133 µmol/l in men 107-124 µmol/l in women
- Low creatinine clearance** (<60 мл/мин)
- Microalbuminuria 30–300 mg/day or albumin/creatinine ratio >22 mg/g in men or >31 mg/g in women

Diabetes

Fasting plasma glucose >7.0 mmol/L (126 mg/dL) on repeat measurements
- Plasma glucose after glucose loading >11.0 mmol/l (198 mg/dl).

Cerebrovascular disease: ischemic stroke, cerebral hemorrhage, transient ischemic attack;
- Heart disease: myocardial infarction, angina pectoris, revascularization, heart failure;
- Kidney damage: diabetic nephropathy, impaired renal function (serum creatinine in men > 133 µmol (> 1.5 mg/dl), in women > 124 µmol/l (> 1.4 mg/dl); proteinuria > 300 mg/dl; day
- Diseases of peripheral arteries
- Severe retinopathy: hemorrhages or exudates, papilledema

Notes:

* - the maximum risk in concentric LVH: an increase in the mass index of the left ventricular myocardium and the ratio of wall thickness and radius> 0.42,
** - Cockcroft-Gault formula

DM in terms of the risk of developing CVC is currently equated with coronary artery disease and, therefore, is similar in significance to ACS.
Associates ( related) clinical conditions
- cerebrovascular disease: Ischemic stroke, hemorrhagic stroke, transient stroke;
- heart disease: Myocardial infarction, angina pectoris, coronary revascularization, CHF;
- kidney disease: diabetic nephropathy; Renal failure (serum creatinine >133 µmol/l (>1.5 mg/dl) for men or >124 µmol/l (>1.4 mg/dl) for women; Proteinuria (>300 mg/day);
- peripheral arterial disease: Dissecting aortic aneurysm, damage to peripheral arteries;
- hypertensive retinopathy: Hemorrhages or exudates, swelling of the nipple of the optic nerve;
- diabetes.
Depending on the degree of BP increase, the presence of RF, POM and ACS, all AH patients can be assigned to one of 4 risk levels: low, medium, high, and very high (Table 3).
Table 3 - Stratification of patients with hypertension according to the risk of developing cardiovascular complications

Other risk factors. POM or disease BP, mm.rt.st.
Normal BP: SBP 20-129 or DBP 80-84 High normal BP: SBP 130-139 or DBP 85-89 I degree of hypertension SBP 140-159 DBP 90-99 II degree hypertension SBP 160-179 DBP 100-109 III degree of hypertension SBP ≥ 180 DBP ≥ 110
No other risk factors Medium risk Medium risk Low additional risk
1-2 risk factors Low additional risk Low additional risk Moderate additional risk Moderate additional risk Very high additional risk
≥3 risk factors, metabolic syndrome, POM, or diabetes mellitus Moderate additional risk High additional risk High additional risk High additional risk Very high additional risk
Established cardiovascular or kidney disease Very high additional risk Very high additional risk Very high additional risk Very high additional risk Very high additional risk


The term "additional risk" is used to emphasize that the risk of CV events and death from them in people with hypertension is always higher than in the general population. Based on the risk stratification, the groups of high and very high risk according to the European guidelines for hypertension (2007) include persons who have changes, are presented in Table 3.
It should be noted that the presence of multiple risk factors, POM, DM and ACS clearly indicates a very high risk (Table 4).

Table 4 - Patients at very high risk


The prognosis of patients with hypertension and the choice of treatment tactics depend on the level of blood pressure and the presence of concomitant risk factors, involvement of target organs in the pathological process, and the presence of associated diseases.
At-risk groups
- Low risk (risk 1)- 1st degree hypertension, no risk factors, target organ damage and associated diseases. The risk of developing CVD and complications in the next 10 years is 15%.
- Medium risk (risk 2)- AH grade 2-3, no risk factors, target organ damage and associated diseases. 1-3 art. Hypertension, there are 1 or more risk factors, no target organ damage (TOD) and associated diseases. The risk of developing cardiovascular complications in the next 10 years is 15-20%.
- High risk (risk 3) - AH 1-3 degree, there is damage to target organs and other risk factors, no associated diseases. The risk of developing cardiovascular complications in the next 10 years is more than 20%.
- Very high risk (risk 4)- AH 1-3 degree, there are risk factors, POM, associated diseases. The risk of developing cardiovascular complications in the next 10 years exceeds 30%.

Diagnostics


II. METHODS, APPROACHES AND PROCEDURES FOR DIAGNOSIS AND TREATMENT

Diagnostic criteria:
1. Connection between an increase in blood pressure and chronic neuropsychological trauma, occupational hazards.
2. Hereditary predisposition (40-60%).
3. More often benign course.
4. Significant fluctuations in blood pressure, especially systolic during the day. The crisis nature of the flow.
5. Clinical signs of increased sympathicotonia, a tendency to tachycardia, sweating, anxiety.
6. Clinical, ECG and radiological signs of AH syndrome.
7. Salus-Gunn syndrome of 1-3 degrees in the fundus.
8. Moderate decrease in the concentration function of the kidneys (isohyposthenuria, proteinuria).
9. The presence of complications of hypertension (IHD, CHF, cerebrovascular accident).

Complaints and anamnesis:
1. The duration of the existence of hypertension, the level of increase in blood pressure, the presence of GC;

- family history of kidney disease (polycystic kidney disease);
- a history of kidney disease, bladder infections, hematuria, abuse of analgesics (parenchymal kidney disease);
- the use of various drugs or substances: oral contraceptives, nasal drops, steroidal and non-steroidal anti-inflammatory drugs, cocaine, erythropoietin, cyclosporins;
- episodes of paroxysmal sweating, headaches, anxiety, palpitations (pheochromocytoma);
- muscle weakness, paresthesia, convulsions (aldosteronism)
3. Risk factors:
- hereditary burden for hypertension, CVD, DLP, DM;
- the presence in the anamnesis of the patient of CVD, DLP, DM;
- smoking;
- irrational nutrition;
- obesity;
- low physical activity;
- snoring and indications of respiratory arrest during sleep (information from the words of the patient's relatives);
- personal characteristics of the patient
4. Data indicating POM and AKC:
- brain and eyes - headache, dizziness, impaired vision, speech, TIA, sensory and motor disorders;
- heart - palpitations, chest pain, shortness of breath, swelling;
- kidneys - thirst, polyuria, nocturia, hematuria, edema;
- peripheral arteries - cold extremities, intermittent claudication
5. Previous antihypertensive therapy: used antihypertensive drugs, their efficacy and tolerability.
6. Evaluation of the possibility of influence on AH environmental factors, marital status, work environment.

Fphysical examination.
Physical examination of a patient with hypertension is aimed at determining RF, signs of a secondary nature of hypertension and organ damage. Height and weight are measured with the calculation of the body mass index (BMI) in kg / m 2, and waist circumference (FROM). Physical examination data indicating the secondary nature of hypertension and organ damage are presented in the table.
Table 5 - Fiscal survey data indicating the secondary nature of hypertension and organ pathology

1. Signs of secondary hypertension;
2. Diagnosis of secondary forms of hypertension:
- symptoms of Itsenko-Cushing's disease or syndrome;
- neurofibromatosis of the skin (may indicate pheochromocytoma);
- on palpation, enlarged kidneys (polycystic kidney disease, volumetric formations);
- auscultation of the abdomen - noises over the abdominal aorta, renal arteries (renal artery stenosis - renovascular hypertension);
- auscultation of the heart, chest (coarctation of the aorta, aortic disease);
- weakened or delayed pulse on the femoral artery and reduced blood pressure on the femoral artery (coarctation of the aorta, atherosclerosis, nonspecific aortoarteritis).
3. Signs of POM and AKC:
- brain - motor or sensory disorders;
- retina - changes in the vessels of the fundus;
- heart - displacement of the boundaries of the heart, increased apex beat, cardiac arrhythmias, assessment of CHF symptoms (wheezing in the lungs, the presence of peripheral edema, determining the size of the liver);
- peripheral arteries - absence, weakening or asymmetry of the pulse, cold extremities, symptoms of skin ischemia;
- carotid arteries - systolic murmur.
4. Indicators of visceral obesity:
- an increase in WC (in a standing position) in men > 102 cm, in women > 88 cm;

- increase in BMI [body weight (kg)/height (m) 2 ]: overweight ≥ 25 kg/m 2 , obesity ≥ 30 kg/m 2 .


Llaboratory research.
Mandatory studies that should be carried out before starting treatment in order to identify target organ damage and risk factors:
- general analysis of blood and urine;
- biochemical blood test (potassium, sodium, glucose, creatinine, uric acid, lipid spectrum).

Instrumental research.
- ECG in 12 leads
- Echocardiography to assess left ventricular hypertrophy, the state of systolic and diastolic functions
- chest x-ray
- eye examination
- ultrasound examination of the arteries
- Ultrasound of the kidneys.

Pproviding expert advice.
Neurologist:
1. Acute disorders of cerebral circulation
- stroke (ischemic, hemorrhagic);
- transient disorders of cerebral circulation.
2. Chronic forms of vascular pathology of the brain
- initial manifestations of insufficiency of blood supply to the brain;
- encephalopathy;
Optometrist:
- hypertensive angioretinopathy;
- hemorrhages in the retina;
- swelling of the nipple of the optic nerve;
- retinal disinsertion;
- progressive loss of vision.
Nephrologist:
- exclusion of symptomatic hypertension;
- daily monitoring of blood pressure.

List of basic and additional diagnostic measures

Main researches:
1. general analysis of blood and urine;
2. the content of glucose in the blood plasma (on an empty stomach);
3. serum levels of total cholesterol, HDL cholesterol, TG, creatinine;
4. determination of creatinine clearance (according to the Cockcroft-Gault formula) or GFR (according to the MDRD formula);
5. ECG;

Additional research:
1. serum levels of uric acid, potassium;
2. determination of total protein and fractions
3. echocardiography;
4. definition of MAU;
5. study of the fundus;
6. Ultrasound of the kidneys and adrenal glands;
7. Ultrasound of brachiocephalic and renal arteries
8. chest x-ray;
9. ABPM and self-monitoring of blood pressure;
10. determination of the ankle-brachial index;
11. determination of the speed of the pulse wave (an indicator of the stiffness of the main arteries);
12. oral glucose tolerance test - when the level of glucose in blood plasma is >5.6 mmol/l (100 mg/dl);
13. quantification of proteinuria (if test strips are positive);
14. Nechiporenko test
15. Rehberg's test
16. Zimnitsky test In-depth study:
17. complicated arterial hypertension - assessment of the state of the brain, myocardium, kidneys, main arteries;
18. detection of secondary forms of hypertension - a study of the concentration of aldosterone, corticosteroids, renin activity in the blood;
19. determination of catecholamines and their metabolites in daily urine and/or blood plasma; abdominal aortography;
20. CT or MRI of the adrenal glands, kidneys and brain, CT or MRA.

Table 7 - Diagnostic studies

Name of service cl Lv. Rationale
24 hour blood pressure monitoring I A Long-term dynamic control of blood pressure, correction of treatment
echocardiography I A Determination of the degree of damage to the myocardium, valves and the functional state of the heart.
General blood analysis I WITH Determination of the overall blood picture
Blood electrolytes I WITH Electrolyte control.
Total protein and fractions I WITH The study of protein metabolism
blood urea I WITH
Blood creatinine I WITH Examination of the state of kidney function
Coagulogram I WITH Determination of the blood coagulation system
Determination of ACT, ALT, bilirubin I WITH Assessment of the functional state of the liver
Lipid spectrum I WITH
General urine analysis I WITH Examination of the state of kidney function
Reberg's test I WITH Examination of the state of kidney function
Nechiporenko test I WITH Examination of the state of kidney function
Zimnitsky's test I WITH Examination of the state of kidney function
Chest X-ray I WITH Determination of the configuration of the heart, diagnosis of stagnation in the pulmonary circulation
Ophthalmologist's consultation
Neurologist's consultation


Differential Diagnosis


Table 6 - Differential diagnosis

Form AG Basic diagnostic methods
Renal AG:
Renovascular hypertension
- infusion renography
- kidney scintigraphy
- Doppler study of blood flow in the renal vessels
- aortography separate determination of renin during renal vein catheterization
Renoparenchymal AH:
Glomerulonephritis

Chronic pyelonephritis

- Rehberg's test, daily proteinuria
- kidney biopsy
- infusion urography
- urine cultures
Endocrine hypertension:
Primary hyperaldosteronism (Kohn's syndrome)
- samples with dichlothiazide and spironaloctone
- determination of the level of aldosterone and plasma renin activity
- CT scan of the adrenal glands
Syndrome or Cushing's disease

Pheochromocytoma and other chromaffin tumors

- determination of the daily dynamics of the level of cortisol in the blood
- test with dexamethasone - determination of ACTH
- visualization of the adrenal glands and pituitary gland (ultrasound, CT, MRI)
- determination of the level of catecholamines and their metabolites in the blood and urine visualization of the tumor (CT, ultrasound, MRI, scintigraphy)
Hemodynamic AH:
Coarctation of the aorta
Aortic valve insufficiency
- Doppler ultrasound examination of the main vessels
- aortography
- echocardiography

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Treatment


Treatment goals:
The main goal of the treatment of patients with hypertension is to minimize the risk of developing CVD and death from them. To achieve this goal, it is required not only to reduce blood pressure to the target level, but also to correct all modifiable risk factors (smoking, DLP, hyperglycemia, obesity), prevent, slow down the rate of progression and / or reduce POM, as well as treat associated and concomitant diseases - IHD, SD, etc.
In the treatment of patients with hypertension, the value of blood pressure should be less than 140/90 mm Hg, which is its target level. With good tolerability of the prescribed therapy, it is advisable to lower blood pressure to lower values. In patients with high and very high risk of CVD, it is necessary to reduce blood pressure.< 140/90 мм.рт.ст. в течение 4 недель. В дальнейшем, при условии хорошей переносимости рекомендуется снижение АД до 130/80 мм.рт.ст. и менее.

Treatment tactics

Non-drug treatment (regime, diet, etc.):
- reduced consumption of alcoholic beverages< 30 г алкоголя в сутки для мужчин и 20 г/сут. для женщин;
- increase in physical activity - regular aerobic (dynamic) physical activity for 30-40 minutes at least 4 times a week;
- reduction of salt intake to 5 g/day;
- a change in diet with an increase in the consumption of plant foods, an increase in the diet of potassium, calcium (found in vegetables, fruits, grains) and magnesium (found in dairy products), as well as a decrease in the consumption of animal fats;
- to give up smoking;
- normalization of body weight (BMI<25 кг/м 2).

Medical treatment

Recommendations for procedures or treatments:
Class I- Reliable evidence and/or consensus among experts that the procedure or treatment is appropriate, useful and effective.
Class II- Conflicting evidence and/or disagreement between experts on the benefits/effectiveness of a procedure or treatment.
Class IIa- prevailing evidence/opinion in support of benefit/effectiveness.
Class IIb - benefit/effectiveness not well supported by evidence/expert opinion.
Class III- Reliable evidence and/or unanimity of expert opinion that the given procedure or type of treatment is not useful/effective, and in some cases may be harmful.
Evidence level A. Data from multiple randomized clinical trials or meta-analysis.
Level of evidence B. Data from a single randomized trial or non-randomized trials.
Level of evidence C. Only expert consensus, case studies or standard of care.

Clinical tactics:
Currently, five main classes of antihypertensive drugs (AHP) are recommended for the treatment of hypertension: angiotensin-converting enzyme inhibitors (ACEIs), AT1 receptor blockers (ARBs), calcium antagonists (ACs), diuretics, and β-blockers (β-blockers). α-ABs and imidazoline receptor agonists can be used as additional classes of antihistamines for combination therapy.

Table 8 - Primary indications for the appointment of various groups of antihypertensive drugs

ACE inhibitor ARB β-AB AK
CHF
LV dysfunction
ischemic heart disease
diabetic nephropathy
Non-diabetic nephropathy
LVH
Atherosclerosis of the carotid arteries
Proteinuria/MAU
Atrial fibrillation
SD
MS
CHF
Postponed MI
diabetic nephropathy
Proteinuria/MAU
LVH
Atrial fibrillation
MS
Cough while taking
ACE inhibitor
ischemic heart disease
Postponed MI
CHF
Tachyarrhythmias
Glaucoma
Pregnancy
(dihydropyridine)
ISAG (elderly)
ischemic heart disease
LVH
Atherosclerosis of the carotid and coronary arteries
Pregnancy
AK (verapamil/dishtiazem)
ischemic heart disease
Atherosclerosis of the carotid arteries
Supraventricular tachyarrhythmias
Thiazide diuretics
ISAG (elderly)
CHF
Diuretics (aldosterone antagonists)
CHF
Postponed MI
Loop diuretics
final stage
CRF
CHF


Table 9 - Absolute and relative contraindications to the appointment of various groups of antihistamines

Drug class Absolute contraindications Relative contraindications
Thiazide diuretics Gout MS, NTG. DLP, pregnancy
β-AB Atrioventricular blockade 2-3 degree BA Peripheral artery disease, MS, IGT, athletes and physically active patients, COPD
AK dihydropyridine Tachyarrhythmias, CHF
AA non-dihydropyridine Atrioventricular blockade of 2-3 degrees, CHF
ACE inhibitor Pregnancy, hyperkalemia, bilateral renal artery stenosis, angioedema
ARB Pregnancy, hyperkalemia, bilateral renal artery stenosis
Aldosterone antagonist diuretics Hyperkalemia, CKD
Table 10 - Recommendations for the choice of drugs for the treatment of patients with hypertension, depending on the clinical situation
Target organ damage
. LVH
. Asymptomatic atherosclerosis
. UIA
. Kidney damage
. ARB, ACE inhibitor. AK
. AK, ACE inhibitor
. ACE inhibitor, ARB
. ACE inhibitor, ARB
Associated clinical conditions
. Previous MI
. Previous MI
. ischemic heart disease
. CHF
. Atrial fibrillation paroxysmal
. Atrial fibrillation constant
. Renal failure/proteinuria
. Peripheral artery disease
. Any antihypertensive drugs
. β-AB, ACE inhibitors. ARB
. β-AB, AK, ACE inhibitors.
. Diuretics, β-blockers, ACE inhibitors, ARBs, aldosterone antagonists
. ACE inhibitor, ARB
. β-AB, non-dihydropyridine AA
. ACE inhibitors, ARBs, loop diuretics
. AK
Special clinical situations
. ISAG (elderly)
. MS
. SD
. Pregnancy
. diuretics, AK
. ARB, ACE inhibitor, AK
. ARB, ACE inhibitor
. AK, methyldopa


Table 11 - List of essential medicines

Name Unit rev. Qty Rationale Cl. Lv.
ACE inhibitors
Enalapril 5 mg, 10 mg, 20 mg
Perindopril 5 mg, 10 mg
Ramipril 2.5 mg, 5 mg, 10 mg
Lisinopril 10 mg, 20 mg
Fosinopril 10 mg, 20 mg
Zofenopril 7.5 mg, 30 mg

Tab.
Tab.
Tab.
Tab.
Tab.
Tab.

30
30
28
28
28
28
I A
Angiotensin receptor blockers
Valsartan 80 mg, 160 mg
Losartan 50 5mg. 100 mg
Candesartan 8 mg, 16 mg

Tab.
Tab.
Tab.

30
30
28
Hemodynamic and organoprotective effects I A
Calcium antagonists, dihydropyridine
Amlodipine 2.5 mg 5 mg, 10 mg
Lercanidipine 10 mg
Nifedipine 10 mg, 20 mg, 40 mg

Tab.
Tab.
Tab.

30
30
28
Expansion of peripheral and coronary vessels, reduction of cardiac afterload and oxygen demand I A
Beta blockers
Metoprolol 50 mg, 100 mg
Bisoprolol 2.5 mg, 5 mg, 10 mg
Carvedilol 6.5 mg, 12.5 mg, 25 mg
Nebivolol 5 mg

Tab.
Tab.
Tab.
Tab.

28
30
30
28
Decrease in myocardial oxygen demand, decrease in heart rate, safety during pregnancy I A
Diuretics
Hydrochlorothiazide 25 mg

Tab.

20
Volumetric unloading of the heart I A
Indapamide 1.5 mg, 2.5 mg

Torasemide 2.5 mg, 5 mg
Furosemide 40 mg,
Spironolactone 25 mg, 50 mg

Tablet, caps.

Tab.
Tab.
Tab.

30

30
30
30

Improvement of vascular endothelial function, decrease in peripheral vascular resistance
Volumetric unloading of the heart
Volumetric unloading of the heart
Hemodynamic unloading of the myocardium

I
I
I
I

A
A
A
A
Combined drugs
ACE inhibitor + diuretic
ARB + ​​diuretic
ACE inhibitor + AK
BRA + AK
Dihydropyridine A C + β-AB
AK + diuretic
I A
Alpha blockers
Urapidil 30 mg, 60 mg, 90 mg
Caps. 30 Decrease in OPSS, decrease in sympathetic influence on the CCC I A
Imidazoline receptor agonists
Moxonidine 0.2 mg, 0.4 mg
Tab. 28 Inhibition of the activity of the vasomotor center, a decrease in the sympathetic effect on the cardiovascular system, a sedative effect I A
Antiplatelet agents
Acetylsalicylic acid 75 mg, 100 mg.
Tab. 30 To improve the rheological properties of blood IIa IN
Statins
Atorvastatin 10 mg, 20 mg
Simvastatin 10 mg, 20 mg, 40 mg
Rosuvastatin 10 mg, 20 mg, 40 mg

Tab.
Tab.
Tab.

30
28
30
Hypolitidemic agent to improve vascular endothelial function I A
acetylsalicylic acid recommended in the presence of a past MI, MI or TIA, if there is no threat of bleeding. Low-dose aspirin is also indicated in patients older than 50 years of age with moderately elevated serum creatinine or at very high risk of CVD even in the absence of other CVD. To minimize the risk of hemorrhagic MI, aspirin treatment should only be started if blood pressure is adequately controlled.
statins to achieve target levels of total cholesterol<4,5 ммоль/л (175 мг/дл) и ХС ЛНП <2,5 ммоль/л (100 мг/дл) следует рассматривать у больных АГ при наличии ССЗ, МС, СД, а также при высоком и очень высоком риске ССО.

Table 12 - Additional diagnostic studies carried out at this stage in hypertensive crisis


Table 13 - Drugs recommended for the relief of hypertensive crises

Name Unit rev. Rationale Cl. Lv.
Nifedipine 10 mg Tab. Hypotensive action I A
Captopril 25 mg Tab. Hypotensive action I A
Urapidil 5 ml, 10 ml Amp. Hypotensive action I A
Enalapril 1.25 mg/1 ml Amp
Isosorbide dinitrate 0.1% - 10.0 ml IV drip Amp. unloading of a small circle of blood circulation IIa WITH
Furosemide 40 mg/day Amp. Unloading big and small<ругов кровообращения I A
Other treatments

Surgical intervention.
Catheter ablation of the sympathetic plexus of the renal artery, or renal denervation.
Indications: resistant arterial hypertension.
Contraindications:
- renal arteries less than 4 mm in diameter and less than 20 mm in length;
- manipulations on the renal arteries (angioplasty, stenting) in history;
- stenosis of the renal arteries more than 50%, renal failure (GFR less than 45 ml / min / 1.75 m 2);
- vascular events (MI, episode of unstable angina, transient ischemic attack, stroke) less than 6 months. before the procedure;
- any secondary form of hypertension.

Preventive measures (prevention of complications, primary prevention for PHC level, indicating risk factors).
- Animal fat-restricted diet rich in potassium
- Reducing the intake of table salt (NaCI) to 4.5 g / day.
- Reducing excess body weight
- Smoking cessation and limiting alcohol consumption
- Regular dynamic physical activity
- Psychorelaxation
- Compliance with the regime of work and rest

Further management (ex: postoperative, rehabilitation, follow-up of the patient at the outpatient level in case of developing a protocol for the hospital)
Achievement and maintenance of target blood pressure levels require long-term medical supervision with regular monitoring of the patient's compliance with recommendations for changing the OB and adherence to the regimen of prescribed antihistamines, as well as correction of therapy depending on the effectiveness, safety and tolerability of treatment. In case of dynamic observation, the establishment of personal contact between the doctor and the patient, the education of patients in schools for patients with hypertension, which increases the patient's adherence to treatment, are of decisive importance.
- When prescribing AHT, scheduled patient visits to the doctor to assess the tolerability, efficacy and safety of treatment, as well as to monitor the implementation of the recommendations received, are carried out at intervals of 3-4 weeks until the target level of blood pressure is reached.
- If AHT is not effective enough, a previously prescribed drug can be replaced or another AGP added to it.
- In the absence of an effective decrease in blood pressure against the background of 2-component therapy, it is possible to add a third drug (one of the three drugs, as a rule, should be a diuretic) with mandatory subsequent monitoring of the effectiveness, safety and tolerability of combination therapy.
- After target BP is achieved with ongoing therapy, follow-up visits are scheduled at 6-month intervals for patients at intermediate and low risk who regularly measure BP at home. For patients at high and very high risk, for patients receiving only non-pharmacological treatment, and for those with low adherence to treatment, the intervals between visits should not exceed 3 months.
- At all planned visits, it is necessary to monitor the implementation of treatment recommendations by patients. Since the state of the target organs changes slowly, it is not advisable to conduct a follow-up examination of the patient to clarify their condition more than once a year.
- With "resistant" hypertension (BP> 140/90 mm Hg during treatment with three drugs, one of which is a diuretic, in submaximal or maximum doses), you should make sure that there are no subjective causes of resistance ("pseudo-resistance") to therapy . In the case of true refractoriness, the patient should be sent for additional examination.
- Treatment of a patient with hypertension is carried out continuously or, in fact, in most patients for life, since its cancellation is accompanied by an increase in blood pressure. With stable normalization of blood pressure for 1 year and compliance with measures to change the OB in patients with low and moderate risk, a gradual reduction in the number and / or doses of antihistamines taken is possible. Reducing the dose and/or reducing the number of medications used necessitates an increase in the frequency of visits to the doctor and home CAD to ensure that there are no recurrent increases in blood pressure.

Indicators of treatment efficacy and safety of diagnostic and treatment methods described in the protocol.

Table 14 - Indicators of treatment efficacy and safety of diagnostic and treatment methods described in the protocol

Goals Main criteria
Short term, 1-6 months. from the start of treatment - Decrease in systolic and/or diastolic blood pressure by 10% or more or achieve the target blood pressure level
- Absence of hypertensive crises
- Preservation or improvement of the quality of life
- Impact on modifiable risk factors
Medium-term, >6 months start of treatment - Achievement of target BP values
- Absence of target organ damage or reverse dynamics of existing complications
- Elimination of modifiable risk factors
Long term - Stable maintenance of blood pressure at the target level
- No progression of target organ damage
- Compensation for existing cardiovascular complications

Hospitalization


Indications for hospitalization indicating the type of hospitalization

Indications for planned hospitalization:
Indications for hospitalization of patients with hypertension are:
- ambiguity of the diagnosis and the need for special, often invasive, research methods to clarify the form of hypertension;
- difficulties in the selection of drug therapy - frequent GC, refractory hypertension.

Indications for emergency hospitalization:
- GC not stopped at the prehospital stage;
- GC with severe manifestations of hypertensive encephalopathy;
- complications of hypertension requiring intensive care and constant medical supervision: ACS, pulmonary edema, MI, subarachnoid hemorrhage, acute visual impairment, etc.;
- malignant hypertension.

Information

Sources and literature

  1. Minutes of the meetings of the Expert Commission on Health Development of the Ministry of Health of the Republic of Kazakhstan, 2013
    1. 1. ESH-EIiC Guidelines Committee. 2007 guidelines for the management of arterial hypertension. J Hyperlension 2007. 2. ESH-EIiC Guidelines Committee. 2009 guidelines for the management of arterial hypertension. J Hypertension 2009. 3. Diseases of the heart and blood vessels. Guidelines of the European Society of Cardiology. Kemm A.D., Lusher T.F., Serruis P.V. Author of the translation: Shlyakhto E.V. 4. Recommendations of the World Health Organization and the International Society for Hypertension 1999. 5. Danilov N.M., Matchin Yu.G., Chazova I.E. Endovascular radiofrequency denervation of the renal arteries is an innovative method for the treatment of refractory arterial hypertension. First experience in Russia // Angiol. and a vessel. Surgery. -2012.No.18(1). -C. 51-56. 6. Cardiovascular prevention. National recommendations. Moscow 2011 1. Yusuf S, Sleight P, Pogue J et al. Effects of an angiotensin-converling-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000; 3;4iL(3): 145--53. 8. The EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease In.restigators. On reduction of cardiac events with Perindopril in stable coronary Artery disease Investigators. Efficacy of perindopril in reduction of cardiovascular evrnts among patients with stable coronirry artery disease: randomised, double-blind, placebo-controlled, multicentre trial (1he IIUROPA study). Lancet 2003; 362:782-8. 9. PROGRESS Collaborative Study Group. Randomisd trial of pelindopril based blood pressurr:-lowering regimen among 6108 individuals with previous stroke or transient ischaenric attack. l-ancet 200t: 358: 1033-41. 10. Lithell H, Hansson L, Skoog I, et al, SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE). Principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21:875-86. 11. Schmieder R.E., Redon J., Grassi G. et al. ESH Posrition Paper: renal denervation - an interventional therapy of resistant hypertension // J. Hypertens. 2012. Vol. 30(5). 12. Krum H., Schlaich M., Whitbourn R. et al. Catheter-based renal svmpathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study // Lancet. 2009 Vol. 373. P. 1275-1281.

Information


III. ORGANIZATIONAL ASPECTS OF PROTOCOL IMPLEMENTATION

List of protocol developers with qualification data

1. Berkinbaev S.F. - Doctor of Medical Sciences, Professor, Director of the Research Institute of Cardiology and Internal Diseases.
2. Dzhunusbekova G.A. - Doctor of Medical Sciences, Deputy Director of the Research Institute of Cardiology and Internal Diseases.
3. Musagalieva A.T. - Candidate of Medical Sciences, Head of the Cardiology Department of the Research Institute of Cardiology and Internal Diseases.

4. Ibakova Zh.O. - Candidate of Medical Sciences, Department of Cardiology, Research Institute of Cardiology and Internal Diseases.

Reviewers: Chief freelance cardiologist of the Ministry of Health of the Republic of Kazakhstan, MD Abseitova S.R.

External review results:

Results of preliminary testing:

Indication of the conditions for revising the protocol: Revision” of the protocol is carried out at least once every 5 years, or upon receipt of new data on the diagnosis and treatment of the corresponding disease, condition or syndrome.
Indication of no conflict of interest: absent.

Evaluation criteria for monitoring and auditing the effectiveness of the implementation of the protocol (a clear listing of criteria and the presence of a link with indicators of treatment effectiveness and / or the creation of indicators specific to this protocol)

Attached files

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Most often, intracranial hypertension (increased intracranial pressure) is manifested due to dysfunction of the cerebrospinal fluid. The process of producing cerebrospinal fluid is enhanced, due to which the liquid does not have time to fully absorb and circulate. Stagnation is formed, which causes pressure on the brain.

With venous congestion, blood can accumulate in the cranial cavity, and with cerebral edema, tissue fluid can accumulate. Pressure on the brain can be exerted by a foreign tissue formed due to a growing neoplasm (including an oncological one).

The brain is a very sensitive organ; for protection, it is placed in a special liquid medium, the task of which is to ensure the safety of brain tissues. If the volume of this liquid changes, then the pressure increases. The disorder is rarely an independent disease, and often acts as a manifestation of a pathology of a neurological type.

Influencing factors

The most common causes of intracranial hypertension are:

  • excessive secretion of cerebrospinal fluid;
  • insufficient degree of absorption;
  • dysfunction of pathways in the fluid circulation system.

Indirect causes provoking the disorder:

  • traumatic brain injury (even long-standing, including birth), head bruises, concussion;
  • encephalitis and meningitis diseases;
  • intoxication (especially alcohol and medication);
  • congenital anomalies in the structure of the central nervous system;
  • violation of cerebral circulation;
  • foreign neoplasms;
  • intracranial hematomas, extensive hemorrhages, cerebral edema.

In adults, the following factors are also distinguished:

  • overweight;
  • chronic stress;
  • violation of the properties of the blood;
  • strong physical activity;
  • the influence of vasoconstrictor drugs;
  • birth asphyxia;
  • endocrine diseases.
Excess weight can be an indirect cause of intracranial hypertension

Due to pressure, the elements of the brain structure can change position relative to each other. This disorder is called dislocation syndrome. Subsequently, such a shift leads to a partial or complete breakdown of the functions of the central nervous system.

In the International Classification of Diseases of the 10th revision, intracranial hypertension syndrome has the following code:

  • benign intracranial hypertension (classified separately) - code G93.2 according to ICD 10;
  • intracranial hypertension after ventricular bypass - code G97.2 according to ICD 10;
  • cerebral edema - code G93.6 according to ICD 10.

The International Classification of Diseases of the 10th revision was introduced into medical practice in the Russian Federation in 1999. The release of the updated classifier of the 11th revision is provided for in 2018.

Symptoms

Based on the factors of influence, the following group of symptoms of intracranial hypertension, which occurs in adults, has been identified:

  • headache;
  • "heaviness" in the head, especially at night and in the morning;
  • sweating;
  • pre-fainting state;

  • nausea accompanied by vomiting;
  • nervousness;
  • fast fatiguability;
  • circles under the eyes;
  • sexual and sexual dysfunction;
  • high blood pressure in humans under the influence of low atmospheric pressure.

The signs are distinguished separately, although a number of the listed symptoms also appear here:

  • congenital hydrocephalus;
  • birth injury;
  • prematurity;
  • infectious disorders during fetal development;
  • an increase in the volume of the head;
  • visual sensitivity;
  • violation of the functions of the visual organs;
  • anatomical anomalies of blood vessels, nerves, brain;
  • drowsiness;
  • weak sucking;
  • shouting, crying.

Drowsiness may be one of the symptoms of intracranial hypertension in a child

The disorder is divided into several types. So benign intracranial hypertension is characterized by increased CSF pressure without changes in the state of the cerebrospinal fluid itself and without congestive processes. Of the visible symptoms, swelling of the optic nerve can be noted, which provokes visual dysfunction. This type does not cause serious neurological disorders.

Intracranial idiopathic hypertension (refers to the chronic form, develops gradually, is also defined as moderate ICH) is accompanied by increased CSF pressure around the brain. It has signs of the presence of a tumor of the organ, although one is actually absent. The syndrome is also known as brain pseudotumor. An increase in the pressure of the cerebrospinal fluid on the organ is caused precisely by stagnant processes: a decrease in the intensity of the processes of absorption and outflow of CSF.

Venous hypertension inside the skull is caused by the appearance of stagnant processes in the veins due to the weakening of the outflow of blood from the cranial cavity. The cause may be thrombosis of the venous sinuses, increased pressure in the chest cavity.

Diagnostics

During the diagnosis, not only clinical manifestations are important, but also the results of a hardware study.

  1. The first step is to measure intracranial pressure. To do this, special needles attached to a manometer are inserted into the spinal canal and into the fluid cavity of the skull.
  2. An ophthalmological examination of the condition of the eyeballs is also carried out for blood filling of the veins and the degree of expansion.
  3. Ultrasound examination of the vessels of the brain will make it possible to establish the intensity of the outflow of venous blood.
  4. MRI and computed tomography are performed in order to determine the degree of discharge of the edges of the ventricles of the brain and the degree of expansion of the fluid cavities.
  5. Encephalogram.

Computed tomography is used to diagnose intracranial hypertension

The diagnostic complex of measures in children and adults is not much different, except that in a newborn, a neurologist examines the condition of the fontanel, checks muscle tone and takes measurements of the head. In children, an ophthalmologist examines the condition of the fundus.

Treatment

Treatment of intracranial hypertension is selected based on the obtained diagnostic data. Part of the therapy is aimed at eliminating the factors of influence that provoke a change in pressure inside the skull. That is, the treatment of the underlying disease.

Treatment of intracranial hypertension can be conservative or surgical. Benign intracranial hypertension may not require any therapeutic measures at all. Unless in adults, in order to increase the outflow of fluid, a diuretic drug effect is required. In infants, the benign type passes over time, the baby is prescribed massage and physiotherapy.

Sometimes glycerol is prescribed for small patients. Oral administration of the drug diluted in a liquid is provided. The duration of therapy is 1.5-2 months, since glycerol acts gently, gradually. In fact, the medicine is positioned as a laxative, therefore, without the appointment of the attending physician, it should not be given to the child.


If medications do not help, then bypass surgery may be needed.

Sometimes a spinal puncture is required. If medical therapy does not work, it may be worth resorting to bypass surgery. The operation takes place in the Department of Neurosurgery. In parallel, the causes that caused increased intracranial pressure are eliminated surgically:

  • removal of a tumor, abscess, hematoma;
  • restoration of a normal outflow of cerebrospinal fluid or the creation of a detour.

At the slightest suspicion of the development of ICH syndrome, you should immediately see a specialist. Especially early diagnosis with subsequent treatment is important in babies. Late response to the problem will subsequently result in various disorders, both physical and mental.

Hypertension Syndrome - dangerous disease, which can manifest itself in children regardless of their gender and age.

If the disease occurs in a newborn child, we are talking about a congenital form, in older children - hypertension syndrome is acquired.

This pathology is considered a symptom of dangerous diseases, so a child who has been diagnosed with this ailment should be under constant medical supervision.

However, this diagnosis is often erroneous, in particular, sometimes hypertension syndrome is diagnosed in children with too big head, although these facts are not related to each other.

It can also increase during moments of intense crying or excessive physical exertion. This is considered a variant of the norm, in this case we are not talking about pathology.

General information

The cranium has a constant volume, however contents may vary.

And if any formations appear in the brain area (benign or malignant), excess fluid accumulates, appear, intracranial pressure rises. This phenomenon is called hypertensive syndrome.

The disease can develop rapidly, or have a sluggish character. The first option involves a rapid increase in symptoms, as a result of this condition, the substance of the brain is destroyed, the child may fall into a coma.

With a sluggish form of the disease, the pressure inside the skull increases gradually, this delivers to the child significant discomfort, permanent significantly worsen the quality of life of a small patient.

ICD code 10 - G93.

Causes

Hypertension syndrome may occur in children of different ages. Depending on age, the causes of the disease are also different.

In newborns

In children and adolescents

Clinical picture hypertension syndrome in newborns and older children may be different, however, the signs of the disease are always pronounced.

In newborns

In children and adolescents

  1. The child constantly refuses the mother's breast.
  2. Capriciousness, frequent causeless crying.
  3. During sleep or at rest, a quiet, drawn-out moan is heard on exhalation.
  4. muscle tissue.
  5. Decreased swallowing reflex.
  6. Convulsions (do not occur in all cases).
  7. Trembling of limbs.
  8. Marked strabismus.
  9. Abundant regurgitation, often turning into vomiting.
  10. Violation of the structure of the eye (the appearance of a white strip between the pupil and the upper eyelid, hiding the iris of the eye with the lower eyelid, swelling of the eyeball).
  11. The tension of the fontanel, the divergence of the bones of the skull.
  12. Gradual excessive increase in the size of the head (by 1 cm or more per month).
  1. Severe headaches that occur mainly in the morning (painful sensations are localized in the temples, forehead).
  2. Nausea, vomiting.
  3. Pressure in the region of the eyes.
  4. Sharp pain that occurs when you change the position of the head (turn, tilt).
  5. Dizziness, disruption of the vestibular apparatus.
  6. Paleness of the skin.
  7. General weakness, drowsiness.
  8. Muscle pain.
  9. Increased sensitivity to bright lights and loud sounds.
  10. An increase in the tone of the muscles of the limbs, as a result of which the child's gait changes (he moves mainly on his toes).
  11. Violation of concentration, memory, decrease in intellectual abilities.

Possible Complications

The brain is a very sensitive organ, any changes lead to disruption of its functioning.

With hypertension syndrome, the brain is in a compressed state, which leads to very unfavorable consequences, in particular, to atrophy of the tissues of the organ.

As a result reduced intellectual development child, the process of nervous regulation of the activity of internal organs is disrupted, which, in turn, leads to the loss of their functionality.

In an advanced case, when squeezing large brain stems, a coma and death may occur.

Diagnostics

To detect pathology, it is not enough just a visual examination and questioning of the patient, so the child must undergo a detailed examination, including:

  • x-ray of the skull;
  • echocardiography;
  • rheoencephalogram;
  • angiography;
  • puncture and examination of the accumulated cerebrospinal fluid.

Methods of treatment

The treatment of the disease may be conservative(using drugs), or surgical.

The second option is prescribed only as a last resort, with a severe course of the disease, when there is a risk of developing serious complications, or with the ineffectiveness of drug treatment.

conservative

In addition to taking medication prescribed by the doctor, the child should follow a special diet and lifestyle.

In particular, it is necessary to reduce fluid intake as much as possible (while avoiding dehydration of the body), as well as to exclude foods that contribute to fluid retention in the body (for example, salty, smoked, pickled foods, strong tea and coffee).

Contraindicated excessive physical activity. As an additional treatment, massage, acupuncture are prescribed, which help relieve pain. It is necessary to take medications, such as:

Surgery

In some cases, when the disease is severe and there is risk of complications The child needs surgery.

This method of treatment is necessary if the cause of the development of the disease is tumor formation.

In this case, the child undergoes a trepanation of the skull, followed by removal of the tumor or foreign body. At accumulation of excess fluid perform a puncture of the brain, or create artificial holes in the vertebrae through which the liquor is excreted.

Forecast

As a rule, the disease has a favorable prognosis and the child can be cured, however, the sooner therapy is prescribed, the better.

It is known that the disease is easier to treat in young children (in infants), therefore, upon detection of the first alarm signals, it is necessary to show the child to the doctor.

Prevention measures

Take care of the prevention of such a dangerous disease as hypertension syndrome, necessary at the stage of pregnancy planning. In particular, the expectant mother must undergo an examination, identify and cure all her chronic diseases.

During the period of bearing a child, a woman must take care of her health, protect herself from viruses and infections, follow all the instructions of the doctor who observes the pregnancy.

Hypertension syndrome is a pathology associated with increased intracranial pressure.

This ailment is very dangerous for children's health, arises due to a variety of reasons and can lead to the development of dangerous consequences, up to the death of the child.

Pathology has a characteristic clinical picture, a set of pronounced signs, having discovered which, it is urgent to show the child to the doctor.

Treatment should be started as early as possible, since the timeliness of therapy depends on the prognosis for recovery.

About hypertension-hydrocephalic syndrome in infants in this video:

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Intracranial hypertension (ICH),ICD-10 code - G93 (other brain lesions (GM))- this is a symptom complex caused by an increase in intracranial pressure (in the cranium) over 15 mm Hg. or 150 mm of water column, measured in the supine position.

The cranial cavity is limited by bones and in it neurons of the brain occupy about 600 ml, glia - 800 ml, extracellular fluid - about 130 ml; and blood occupy about 150 ml.

An increase in intracranial pressure occurs when a certain critical volume is reached. At the same time, it was noted that a small increase in the amount of cerebrospinal fluid does not cause hypertension, and if the volume of the GM increases, or a volumetric formation appears in the cranial cavity, then the pressure will necessarily become high.

This is due to the fact that when intracranial pressure increases, especially due to the presence of a volumetric process, the difference in pressure between different areas inside the skull that separates the duplication of the dura (dura) meninges (MO), including the posterior cranial fossa and subarachnoid (subarachnoid) space of the spinal cord (SM).

As a result, there is a displacement of one or another department of the GM from an area of ​​higher pressure to a lower pressure area through natural holes, which are formed by the dural MO (cerebellum and falx GM), or bone formations (large foramen magnum).

That is, wedging (or wedging) of the brain develops with further infringement of the GM substance, compression of adjacent departments and arteries, which leads to ischemia of certain areas of the GM, and there is a violation of the outflow of cerebrospinal fluid due to blockade of its pathways, which further exacerbates the pathological process.

Three variants of brain herniation syndrome

  • Under the crescent GM with a shift of the cingulate gyrus under its lower edge. It occurs more often than other species, but the symptoms in almost all cases cannot be identified;
  • Transtentorially, with displacement of the inner part of the temporal lobe (often the hook of the parahippocampal gyrus) into a depression formed by the cerebellar tenon, where the midbrain (CM) is located. In this case, the oculomotor nerve and the SC itself are compressed, less often - the posterior cerebral artery (PCA) and the upper parts of the brain stem;
  • In the region of the cerebellum, which leads to the displacement of its tonsils into the space of the foramen magnum.

Benign intracranial hypertension (more common in children and young women)

A rare disease is singled out - benign intracranial hypertension (BCH), ICD-10 code - G93.2.

This affects mainly young women and children who are overweight. Until the end, the cause is unknown, there are no changes in the size of the ventricles, obstacles to the flow of cerebrospinal fluid and changes in its composition, there is no intracranial volumetric process.

In some cases, the superior sagittal (sagittal) or transverse sinus is blocked, which is combined with obesity and increased or decreased thyroid function.

Less often, the disease appears against the background of excessive intake of vitamin A, during treatment with gluocorticosteroids, oral contraceptives, some antibacterial drugs (nalidixic acid - especially in children, nitrofurans, tetracyclines), hormonal drugs (danazol). There is also a disease in pregnant women, after childbirth and in those suffering from iron deficiency anemia. For the most part, the cause of DHF remains unknown (idiopathic).

Statistically, based on its causes, intracranial hypertension is more common in men, with the exception of benign ICH, which affects females, including children.

Causes


Liquor pathways in 3D. They increase ICP (ICH).

Cause it to appear:

  • The presence of a volumetric formation inside the cranial cavity (benign and malignant neoplasms, various types of hematomas);
  • An increase in itself or with benign intracranial hypertension;
  • An increase in the amount of cerebrospinal fluid (hydrocephalus);
  • An increase in blood volume when, with an increase in carbon dioxide in it (hypercapnia), the blood vessels expand significantly (vasodilate).

Separately distinguish the syndrome primary increased intracranial pressure due to DVCH with or without fundus edema and secondary:

  • in the first place are craniocerebral injuries;
  • tumors;
  • meningoencephalitis;
  • thrombosis of venous sinuses;
  • somatic diseases in the form of diseases of the kidneys, thyroid gland and systemic lupus erythematosus (SLE);
  • taking medications (nevigramon, anabolics, etc.).

Clinical signs (symptoms)

The main manifestations of ICH consist of the symptoms of the underlying disease that caused it (increase in basal metabolism, body temperature, blood pressure, heart rate in hyperthyroidism) and the main manifestations of the increase in pressure in the cranial cavity itself:

  • cephalgia, or. They are expressed in the morning, because. ICP increases during sleep due to the accumulation of carbon dioxide and compensatory vasodilatation of brain vessels. At the same time, due to the influx of blood, the walls of the arteries and the dural MO itself at the base of the skull are stretched;
  • nausea with or without vomiting. Also a characteristic feature is its intensification in the morning, and cephalgia after vomiting decreases or disappears altogether;
  • drowsiness, which is a warning sign in view of the rapid and significant aggravation of neurological symptoms;
  • disturbances of consciousness of varying severity, if the upper sections of the trunk are compressed;
  • edema of the optic discs due to increased pressure in the subarachnoid space that surrounds the nerve and impaired axoplasmic transport. At the beginning, the retinal veins expand, then the disk protrudes with the development of hemorrhages along its edge (“tongues of flame”), which, with a long course, leads to complete blindness;
  • diplopia (doubling of objects) with compression of the abducens nerve (ON);
  • mydriasis (dilated pupil) with paralysis of the eye muscles (ophthalmoplegia) on the affected side and hemiparesis on the other side with compression of the parahippocampal gyrus;
  • ischemia of the occipital cortex and hemianopsia (blindness of half of the visual field on both sides) with compression of the posterior cerebral artery;
  • arterial hypertension with bradycardia (Kocher-Cushing syndrome);
  • respiratory failure of the Cheyne-Stokes type;
  • forced tilt of the head anteriorly with compression of the bulbar part of the GM;
  • stiffness of the neck muscles during irritation of the dural meningeal membrane - as a manifestation.

In young children with cephalgia, the general condition is disturbed, they become restless, capricious; in newborns and children up to a year, the fontanelles become tense and bulge significantly; as the condition progresses, the child's consciousness is disturbed, he becomes lethargic, adynamic, up to the development of coma.

Treatment (drugs)


Liquor paths.

The main principle of treatment of ICH is etiological, that is, the elimination of the original cause of its cause. If necessary, an intracranial formation (tumor or hematoma) is removed, or the CSF system is shunted (with hydrocephalus). In case of violation of the function of the respiratory system and consciousness, tracheal intubation with artificial lung ventilation (ALV) is performed, parenteral nutrition is established, and the water and electrolyte composition is balanced.

In preparation for surgical treatment in order to reduce ICP, osmotic diuretics (mannitol, glycerol) are used, which contribute to the transfer of water from extravascular spaces into the blood plasma; glucocorticosteroids (dexamethasone) to restore the blood-brain barrier (BBB); loop diuretic (furosemide).

With benign intracranial hypertension, recovery occurs spontaneously after a few weeks or months.

The same conservative therapy is successfully used, and decompression of the optic canal is performed to reduce pressure on the optic nerve.

  • DHD is a diagnosis of exclusion.

    Epidemiology In men, it is observed 2-8 times more often, in children - equally often in both sexes. Obesity is observed in 11-90% of cases, more often in women. The frequency among overweight women of childbearing age is 19/37% of cases are recorded in children, 90% of whom are aged 5–15 years, very rarely younger than 2 years. The peak of the disease is 20–30 years.

    Symptoms (signs)

    Clinical picture Symptoms Headache (94% of cases), more pronounced in the morning Dizziness (32%) Nausea (32%) Change in visual acuity (48%) Diplopia, more often in adults, usually due to abducens nerve paresis (29%) Neurological disorders usually limited to the visual system Optic disc edema (sometimes unilateral) (100%) Abducens nerve involvement in 20% of cases Increased blind spot (66%) and concentric narrowing of visual fields (blindness is rare) Visual field defect (9%) Initial form may be accompanied only by an increase in the occipital-frontal circumference of the head, often resolves on its own and usually requires only observation without specific treatment Absence of consciousness disorders, despite high ICP Concomitant pathology Appointment or withdrawal of GC Hyper-/hypovitaminosis A Use of other drugs: tetracycline, nitrofurantoin, isotretinoin Sinus thrombosis dura mater SLE Menstrual irregularities Anemia (especially iron deficiency).

    Diagnostics

    Diagnostic criteria CSF pressure above 200 mm of water. The composition of the cerebrospinal fluid: a decrease in protein content (less than 20 mg%) Symptoms and signs associated only with increased ICP: edema of the optic nerve head, headache, absence of focal symptoms (permissible exception - abducens nerve paresis) MRI / CT - no pathology. Permissible exceptions: Slit-like form of the ventricles of the brain Enlargement of the ventricles of the brain Large accumulations of cerebrospinal fluid over the brain in the initial form of DHD.

    Investigation methods MRI / CT with and without contrast Lumbar puncture: measurement of CSF pressure, analysis of CSF for at least the content of protein TAC, electrolytes, PV Examinations to rule out sarcoidosis or SLE.

    Differential diagnosis CNS lesions: tumor, brain abscess, subdural hematoma Infectious diseases: encephalitis, meningitis (especially basal or caused by granulomatous infections) Inflammatory diseases: sarcoidosis, SLE Metabolic disorders: lead poisoning Vascular pathology: occlusion (dura sinus thrombosis) or partial obstruction, Behçet's syndrome Membranous carcinomatosis.

    Treatment

    Diet management tactics No. 10, 10a. Restriction of fluid and salt intake Repeat thorough ophthalmological examination, including ophthalmoscopy and determination of visual fields with an assessment of the size of the blind spot Follow-up for at least 2 years with repeat MRI / CT to rule out a brain tumor Withdrawal of drugs that can cause DHD Weight loss body Careful outpatient monitoring of patients with asymptomatic DHD with periodic evaluation of visual functions. Therapy is indicated only for unstable conditions.

    Drug therapy - diuretics Furosemide at an initial dose of 160 mg / day in adults; the dose is selected depending on the severity of symptoms and visual disturbances (but not on CSF pressure); if ineffective, the dose can be increased to 320 mg / day Acetazolamide 125-250 mg orally every 8-12 hours If ineffective, additional dexamethasone 12 mg / day is recommended, but the possibility of increasing body weight should be considered.

    Surgical treatment is performed only in patients resistant to drug therapy or with imminent loss of vision Repeated lumbar punctures until remission is achieved (25% - after the first lumbar puncture) Bypass Lumbar: lumboperitoneal or lumbopleural Other methods of bypass (especially in cases where arachnoiditis prevents access to lumbar arachnoid space): ventriculoperitoneal shunting or shunting of a large cisterna Fenestration of the optic nerve sheath.

    Course and prognosis In most cases, remission by 6-15 weeks (relapse rate - 9-43%) Visual disorders develop in 4-12% of patients. Vision loss is possible without prior headache and papilledema.

    Synonym. Idiopathic intracranial hypertension

    ICD-10 G93.2 Benign intracranial hypertension G97.2 Intracranial hypertension after ventricular bypass surgery

    Application. Hypertensive-hydrocephalic syndrome is caused by an increase in CSF pressure in patients with hydrocephalus of various origins. It is manifested by headache, vomiting (often in the morning hours), dizziness, meningeal symptoms, stupor, and congestion in the fundus. On craniograms, deepening of digital impressions, expansion of the entrance to the "Turkish saddle", and an increase in the pattern of diploic veins are found.

    Signs and methods of elimination of intracranial hypertension

    Most often, intracranial hypertension (increased intracranial pressure) is manifested due to dysfunction of the cerebrospinal fluid. The process of producing cerebrospinal fluid is enhanced, due to which the liquid does not have time to fully absorb and circulate. Stagnation is formed, which causes pressure on the brain.

    With venous congestion, blood can accumulate in the cranial cavity, and with cerebral edema, tissue fluid can accumulate. Pressure on the brain can be exerted by a foreign tissue formed due to a growing neoplasm (including an oncological one).

    The brain is a very sensitive organ; for protection, it is placed in a special liquid medium, the task of which is to ensure the safety of brain tissues. If the volume of this liquid changes, then the pressure increases. The disorder is rarely an independent disease, and often acts as a manifestation of a pathology of a neurological type.

    Influencing factors

    The most common causes of intracranial hypertension are:

    • excessive secretion of cerebrospinal fluid;
    • insufficient degree of absorption;
    • dysfunction of pathways in the fluid circulation system.

    Indirect causes provoking the disorder:

    • traumatic brain injury (even long-standing, including birth), head bruises, concussion;
    • encephalitis and meningitis diseases;
    • intoxication (especially alcohol and medication);
    • congenital anomalies in the structure of the central nervous system;
    • violation of cerebral circulation;
    • foreign neoplasms;
    • intracranial hematomas, extensive hemorrhages, cerebral edema.

    In adults, the following factors are also distinguished:

    • overweight;
    • chronic stress;
    • violation of the properties of the blood;
    • strong physical activity;
    • the influence of vasoconstrictor drugs;
    • birth asphyxia;
    • endocrine diseases.

    Excess weight can be an indirect cause of intracranial hypertension

    Due to pressure, the elements of the brain structure can change position relative to each other. This disorder is called dislocation syndrome. Subsequently, such a shift leads to a partial or complete breakdown of the functions of the central nervous system.

    In the International Classification of Diseases 10 revision, the syndrome of intracranial hypertension has the following code:

    • benign intracranial hypertension (classified separately) - code G93.2 according to ICD 10;
    • intracranial hypertension after ventricular bypass - code G97.2 according to ICD 10;
    • cerebral edema - code G93.6 according to ICD 10.

    The International Classification of Diseases, 10th revision, was introduced into medical practice in the Russian Federation in 1999. The release of the updated classifier of the 11th revision is provided for in 2017.

    Symptoms

    Based on the factors of influence, the following group of symptoms of intracranial hypertension, which occurs in adults, has been identified:

    • headache;
    • "heaviness" in the head, especially at night and in the morning;
    • vegetovascular dystonia;
    • sweating;
    • tachycardia;
    • pre-fainting state;
    • nausea accompanied by vomiting;
    • nervousness;
    • fast fatiguability;
    • circles under the eyes;
    • sexual and sexual dysfunction;
    • high blood pressure in humans under the influence of low atmospheric pressure.

    Separately, there are signs of intracranial hypertension in a child, although a number of the listed symptoms also appear here:

    • congenital hydrocephalus;
    • birth injury;
    • prematurity;
    • infectious disorders during fetal development;
    • an increase in the volume of the head;
    • visual sensitivity;
    • violation of the functions of the visual organs;
    • anatomical anomalies of blood vessels, nerves, brain;
    • drowsiness;
    • weak sucking;
    • shouting, crying.

    Drowsiness may be one of the symptoms of intracranial hypertension in a child

    The disorder is divided into several types. So benign intracranial hypertension is characterized by increased CSF pressure without changes in the state of the cerebrospinal fluid itself and without congestive processes. Of the visible symptoms, swelling of the optic nerve can be noted, which provokes visual dysfunction. This type does not cause serious neurological disorders.

    Intracranial idiopathic hypertension (refers to the chronic form, develops gradually, is also defined as moderate ICH) is accompanied by increased CSF pressure around the brain. It has signs of the presence of a tumor of the organ, although one is actually absent. The syndrome is also known as brain pseudotumor. An increase in the pressure of the cerebrospinal fluid on the organ is caused precisely by stagnant processes: a decrease in the intensity of the processes of absorption and outflow of CSF.

    Diagnostics

    During the diagnosis, not only clinical manifestations are important, but also the results of a hardware study.

    1. The first step is to measure intracranial pressure. To do this, special needles attached to a manometer are inserted into the spinal canal and into the fluid cavity of the skull.
    2. An ophthalmological examination of the condition of the eyeballs is also carried out for blood filling of the veins and the degree of expansion.
    3. Ultrasound examination of the vessels of the brain will make it possible to establish the intensity of the outflow of venous blood.
    4. MRI and computed tomography are performed in order to determine the degree of discharge of the edges of the ventricles of the brain and the degree of expansion of the fluid cavities.
    5. Encephalogram.

    Computed tomography is used to diagnose intracranial hypertension

    The diagnostic complex of measures in children and adults is not much different, except that in a newborn, a neurologist examines the condition of the fontanel, checks muscle tone and takes measurements of the head. In children, an ophthalmologist examines the condition of the fundus.

    Treatment

    Treatment of intracranial hypertension is selected based on the obtained diagnostic data. Part of the therapy is aimed at eliminating the factors of influence that provoke a change in pressure inside the skull. That is, the treatment of the underlying disease.

    Treatment of intracranial hypertension can be conservative or surgical. Benign intracranial hypertension may not require any therapeutic measures at all. Unless in adults, in order to increase the outflow of fluid, a diuretic drug effect is required. In infants, the benign type passes over time, the baby is prescribed massage and physiotherapy.

    Sometimes glycerol is prescribed for small patients. Oral administration of the drug diluted in a liquid is provided. The duration of therapy is 1.5-2 months, since glycerol acts gently, gradually. In fact, the medicine is positioned as a laxative, therefore, without the appointment of the attending physician, it should not be given to the child.

    If medications do not help, then bypass surgery may be needed.

    Sometimes a spinal puncture is required. If medical therapy does not work, it may be worth resorting to bypass surgery. The operation takes place in the Department of Neurosurgery. In parallel, the causes that caused increased intracranial pressure are eliminated surgically:

    • removal of a tumor, abscess, hematoma;
    • restoration of a normal outflow of cerebrospinal fluid or the creation of a detour.

    At the slightest suspicion of the development of ICH syndrome, you should immediately see a specialist. Especially early diagnosis with subsequent treatment is important in babies. Late response to the problem will subsequently result in various disorders, both physical and mental.

    Other disorders of the brain (G93)

    Porencephalic cyst, acquired

    Excluded:

    • periventricular acquired cyst of newborn (P91.1)
    • congenital cerebral cyst (Q04.6)

    Excluded:

    • complicating:
      • abortion, ectopic or molar pregnancy (O00-O07, O08.8)
      • pregnancy, childbirth or delivery (O29.2, O74.3, O89.2)
      • surgical and medical care (T80-T88)
    • neonatal anoxia (P21.9)

    Excludes: hypertensive encephalopathy (I67.4)

    Benign myalgic encephalomyelitis

    Compression of the brain (trunk)

    Infringement of the brain (trunk)

    Excluded:

    • traumatic compression of brain (S06.2)
    • traumatic compression of brain, focal (S06.3)

    Excludes: cerebral edema:

    • due to birth trauma (P11.0)
    • traumatic (S06.1)

    Radiation-induced encephalopathy

    If it is necessary to identify an external factor, use an additional external cause code (class XX).

    In Russia, the International Classification of Diseases of the 10th revision (ICD-10) is adopted as a single regulatory document for accounting for morbidity, reasons for the population to apply to medical institutions of all departments, and causes of death.

    ICD-10 was introduced into healthcare practice throughout the Russian Federation in 1999 by order of the Russian Ministry of Health dated May 27, 1997. №170

    The publication of a new revision (ICD-11) is planned by WHO in 2017 2018.

    With amendments and additions by WHO.

    Processing and translation of changes © mkb-10.com

    Intracranial hypertension code μb 10

    Causes, treatment and prognosis for cerebral dystonia

    Cerebral dystonia is a disorder of the autonomic nervous system, in which organs and tissues are supplied with insufficient oxygen. The disease occurs both in adults (up to 70% of cases) and in children (up to 25%). Males suffer from this disease more often than women.

    Symptoms of the disease

    Symptoms of cerebral dystonia are different. This condition is one of the manifestations of vegetovascular dystonia.

    1. intracranial pressure.
    2. Disorders from the nervous system - irritability, tearfulness. Headache and dizziness, muscle twitches (tics) are possible. The appearance of tinnitus is characteristic, sleep suffers, unsteadiness of gait is noted.
    3. Fluctuations in pressure in the direction of increasing or decreasing.
    4. Puffiness of the face and swelling of the eyelids.
    5. Nausea, sometimes vomiting.
    6. Rapid fatigue, general weakness, decreased performance.

    Causes of the disease

    In children, vascular dystonia is formed due to a discrepancy between the rate of development and the level of maturity of the neurohormonal apparatus, and also if there is a hereditary predisposition.

    In adults, the causes of the disease are:

    1. Exhaustion of the body due to intoxication, trauma or previous infectious diseases.
    2. Sleep disturbances, which are manifested by early awakening in the morning, difficulty falling asleep for a long time or insomnia.
    3. Spleen, depressed mood, constant fatigue.
    4. Wrong diet, unhealthy diet.
    5. Lack of physical activity or, conversely, too active lifestyle.
    6. Imbalance of hormones during childbearing and menopause in women, and puberty in adolescents.
    7. endocrine disorders.
    8. Having bad habits.
    9. Squeezing of the vessels of the neck with osteochondrosis, as a result of which the flow of blood to the brain is disturbed.
    10. Sudden change in climate or time zone.
    11. Bad environment in the region.

    Diagnosis and treatment of the disease

    To establish such a diagnosis as dystonia of cerebral vessels, you need to consult a neurologist, therapist, surgeon, endocrinologist, cardiologist. It is these specialists who will help to exclude organic diseases and confirm or refute the presence of vascular dystonia.

    In the process of diagnosis, the following examinations are carried out:

    1. Urinalysis and blood tests.
    2. Functional examinations, including electrocardiography, duplex scanning of the vessels of the head and neck; transcranial dopplerography may be needed.
    3. X-ray of the spine (cervical), skull.
    4. In some cases, one cannot do without tomography (computer and magnetic resonance imaging).

    Drug therapy for vascular dystonia involves the use of various groups of drugs to improve the functioning of the autonomic nervous system. These include:

    1. Calming drugs containing barbiturates, bromides, valerian and hawthorn.
    2. Means for improving blood circulation in the brain.
    3. Drugs affecting the autonomic and central nervous systems - antidepressants, antipsychotics, hypnotics, nootropics, psychostimulants based on caffeine.
    4. Vitamin complexes, antioxidants, diuretics, calcium preparations, adaptogens with extract of eleutherococcus, magnolia vine, ginseng can also be used.
    5. To reduce the excitability of the autonomic nervous system and improve processes, doctors prescribe Glycine. This amino acid helps to improve metabolic processes in the brain. As a result, the asthenoneurotic component of dystonia becomes less pronounced.

    Massage, acupuncture, herbal medicine, physiotherapy and water treatments are shown as an addition to treatment for vascular dystonia.

    Rest and treatment in a sanatorium can be used as rehabilitation for a disease.

    If the patient has been diagnosed with vascular dystonia, doctors recommend:

    1. Follow the daily routine. Every day a person should sleep at least eight hours. Sound sleep helps to normalize blood pressure.
    2. Frequently ventilate the room in which you sleep. Alternate physical and mental stress. Spend as little time as possible in front of the computer. At least two hours a day to walk in the air.
    3. Do physical exercises, go swimming, ride a bike, ski, skate. During training, avoid exercises with a range of movement of the head and torso, sharp turns.
    4. Temper. Every day, wipe the body with a damp towel. Perform hydromassage, take a contrast shower. Coniferous-salt and radon baths will benefit.

    Success in the treatment of the disease largely depends on the psycho-emotional state of the patient. Learn the rules of relaxation, take part in auto-training, use methods of psychological relief.

    Consequences of the disease

    As a rule, the disease at the initial stage does not harm health and does not lead to serious consequences. However, the symptoms of the disease interfere with normal work and study, cause anxiety and fatigue.

    The disease in the chronic form is severe, and if not properly treated, it can lead to the development of hypertension, coronary disease, and subsequently to stroke and myocardial infarction.

    Timely and competent treatment is the key to success. After the therapy, in 90% of cases, the symptoms of the disease disappear, sleep and appetite are normalized, and the adaptive abilities of the body are restored.

    Syndrome of intracranial hypertension in children and adults

    Intracranial hypertension is increased pressure in the skull. Intracranial pressure (ICP) is the force with which intracerebral fluid presses on the brain. Its increase, as a rule, is due to an increase in the volume of the contents of the cranial cavity (blood, cerebrospinal fluid, tissue fluid, foreign tissue). ICP can periodically increase or decrease due to changes in environmental conditions and the need for the body to adapt to them. If its high values ​​persist for a long time, the syndrome of intracranial hypertension is diagnosed.

    The causes of the syndrome are different, most often these are congenital and acquired pathologies. Intracranial hypertension in children and adults develops with hypertension, cerebral edema, tumors, traumatic brain injuries, encephalitis, meningitis, hydrocephalus, hemorrhagic strokes, heart failure, hematomas, abscesses.

    Intracranial hypertension is classified according to the causes of its development:

    • Acute. Occurs with strokes, fast-growing tumors and cysts, brain injuries. Occurs suddenly, often fatal.
    • Moderate. It is periodically observed in persons with vegetovascular dystonia and in healthy people with meteosensitive dependence. The pressure inside the skull usually rises with a sudden change in weather.
    • Venous. It is associated with a violation of the outflow of blood from the cranial cavity, which occurs when the veins are compressed in osteochondrosis and tumor processes, when the lumen of the veins is closed by blood clots.
    • Benign intracranial hypertension (DHD), or idiopathic. This form has no obvious causes of occurrence and develops in healthy people.

    Main symptoms

    Signs of intracranial hypertension can vary from person to person. The most characteristic are the following:

    • Headache. This is the main symptom of pathology, most often occurring in the morning. The headache is usually bursting, it may be accompanied by nausea and vomiting, aggravated by coughing, sneezing, bending over.
    • Violation of vision. Manifested by fog and double vision, impaired clarity, pain, aggravated by rotation of the eyeballs, the appearance of flies and flickering before the eyes.
    • Drowsiness and lethargy.
    • Hearing impairment. Its decrease, crackling or feeling of fullness in the ears.

    The appearance of these signs in adults, adolescents and children does not yet indicate the development of intracranial hypertension, but requires a mandatory examination.

    Increased ICP can also have indirect symptoms, including:

    • sleep disturbance;
    • nosebleeds;
    • trembling of fingers and chin.

    Intracranial hypertension in children

    Increased ICP in children leads to disturbances in the development of the brain, so it is important to detect the pathology as early as possible.

    In children, two types of pathology are distinguished:

    1. The syndrome slowly increases in the first months of life, when the fontanelles are not closed.
    2. The disease develops rapidly in children after a year, when the seams and fontanelles are closed.

    In children under one year old, due to open cranial sutures and fontanelles, the symptoms are usually unexpressed. Compensation occurs due to the opening of the sutures and fontanelles and an increase in the volume of the head.

    The first type of pathology is characterized by the following symptoms:

    • the child often and for a long time cries for no reason;
    • fontanelles swell, pulsation is not heard in them;
    • vomiting occurs several times a day;
    • the baby sleeps little;
    • cranial sutures diverge;
    • the skull is not large for its age;
    • the bones of the skull are formed disproportionately, the forehead protrudes unnaturally;
    • veins are clearly visible under the skin;
    • children lag behind in development, later they begin to hold their heads and sit;
    • when the child looks down, a white stripe of the white of the eyeball is visible between the iris and the upper eyelid.

    When fontanelles and cranial sutures overgrow, manifestations of intracranial hypertension become pronounced. At this time, the child develops the following symptoms:

    In this case, you must definitely call an ambulance.

    The syndrome can also develop at an older age. In children from two years of age, the disease manifests itself as follows:

    • in the morning, on waking, bursting headaches appear that press on the eyes;
    • when lifting, the pain weakens or recedes due to the outflow of cerebrospinal fluid;
    • the functions of the sense organs are disturbed due to the accumulation of cerebrospinal fluid;
    • vomiting occurs;
    • the child is stunted, overweight.

    Diagnosis in children

    The diagnosis can be made at three stages: in the prenatal period, at birth, during routine examinations of infants.

    To identify pathology in a child, the following steps are necessary:

    • examination by a pediatrician;
    • examination by an ophthalmologist;
    • consultation with a neurologist;
    • NSG (neurosonography);
    • brain x-ray;
    • MRI and characteristic MR signs.

    Treatment

    The method of treatment is chosen by the doctor depending on the manifestations of the disease. With mild symptoms, non-drug therapy is indicated, which includes:

    • special diet and drinking regimen;
    • therapeutic exercises and massage;
    • physiotherapy;
    • swimming;
    • acupuncture.

    Pathology of moderate severity is treated with drugs. In severe cases, surgical intervention is indicated, which consists in creating channels for the outflow of cerebrospinal fluid.

    The outcome of treatment will depend on whether it was started in a timely manner.

    Intracranial hypertension in adults

    Symptoms in adults are determined by disturbances in the functioning of the central nervous system caused by pressure on the brain. These include:

    • pressing pains in the head in the second half of the night and in the morning;
    • nausea, vomiting in the morning;
    • decrease or increase in blood pressure;
    • tachycardia;
    • sweating;
    • increased fatigue;
    • nervousness;
    • blue circles under the eyes, a pronounced venous pattern on the skin under the eyes;
    • meteosensitivity, worsening condition when the weather changes;
    • hallucinations;
    • after taking a horizontal position, there is an increased release of cerebrospinal fluid and a slow reabsorption, hence the severity of symptoms in the second half of the night and in the morning.

    If symptoms persist for a long time, encephalopathy may develop.

    In addition, residual encephalopathy may develop, the occurrence of which is due to damage to the nervous tissue. It usually progresses slowly and signs of brain dysfunction increase gradually. Residual encephalopathy is manifested by mood swings, sleep disturbances, headaches, dizziness, and general weakness.

    Diagnostics

    Measurement of intracranial pressure is possible only in an invasive way. To do this, you need to insert the needle, to which the manometer is connected, into the spinal canal. The diagnosis is made by identifying symptoms that indicate intracranial hypertension. This is done through the following types of surveys:

    • examination by a neurologist;
    • lumbar puncture;
    • fundus examination;
    • brain x-ray;
    • rheoencephalography.

    Adult Treatment

    The syndrome of intracranial pressure requires immediate treatment, otherwise the body will not be able to function normally. With increased ICP, intelligence decreases, which affects mental performance.

    The essence of symptomatic treatment is to reduce the production of cerebrospinal fluid and to increase its reabsorption. For this, diuretics are used.

    If diuretic therapy fails, corticosteroids are prescribed along with vasodilators and barbiturates. Steroid drugs help to reduce the permeability of the blood-brain barrier. Troxevasin is used to improve the outflow of venous blood, and drugs from the group of non-steroidal anti-inflammatory drugs and anti-migraine drugs are used to relieve pain. In addition, vitamins and medications may be indicated to improve the transmission of neuronal impulses.

    With a mild form of the disease, special exercises and a special drinking regimen are usually prescribed to reduce pressure in the cranial cavity. With the help of physiotherapy, the venous bed in the head is unloaded. With the help of these measures, it is possible to reduce intracranial pressure and reduce symptoms within a week, even without taking diuretics, which an adult may not always take constantly.

    Most often, a lumbar puncture is used to mechanically remove a small amount (no more than 30 ml at a time) of CSF. In some cases, improvement occurs the first time, but, as a rule, more than one procedure is needed. The frequency of carrying out is one manipulation in two days.

    Another option for surgical intervention is shunting, or the implantation of tubes through which the outflow of CSF will be carried out. This method has a more pronounced and lasting effect.

    Intracranial hypertension can be eliminated only if the cause of its occurrence, that is, another disease, is eliminated.

    Mild forms of pathology in adults can be treated with folk remedies:

    • Grind garlic and lemons, add water, let it brew for a day. Strain and take a tablespoon for two weeks. One and a half liters of water will require two lemons and two heads of garlic.
    • Mix equal amounts of crushed leaves of hawthorn, mint, eucalyptus, valerian and motherwort. Pour vodka (0.5 l) with a tablespoon of the mixture, leave for seven days. Strain and take 20 drops three times a day for a month.
    • Pour clover flowers with vodka (0.5 l) and leave for two weeks. Strain and take three times a day, a tablespoon diluted in half a glass of water.
    • Dried lavender leaves (tablespoon) chop and pour boiling water (0.5 l), leave for an hour. Strained infusion drink a tablespoon half an hour before meals for 1 month.

    Separately, it should be said about benign intracranial hypertension (code G93.2 according to ICD 10). This is a temporary increase in ICP without signs of infection, hydrocephalus, hypertensive encephalopathy, and may be caused by hormonal changes, obesity, hypovitaminosis, thyroid disease, pregnancy, hormone intake, and other factors.

    The main difference between DHD and the pathological form of the disease is the absence of signs of depressed consciousness. Typically, patients complain of headaches, which are aggravated by coughing and sneezing.

    Most often, benign intracranial hypertension does not require specific treatment and resolves on its own. Diuretics can be prescribed, which are usually enough to normalize the pressure. In addition, it is recommended to limit the amount of fluid consumed, follow a salt-free diet and perform special exercises.

    Diet

    Nutrition and drinking regimen should help ensure that the body cannot accumulate fluid. To do this, you must adhere to the following rules:

    • exclude salt from the diet;
    • refuse smoked and flour;
    • do not drink purchased juices and carbonated drinks;
    • do not drink alcoholic beverages;
    • refrain from fast food.

    Conclusion

    Treatment of intracranial hypertension should begin as early as possible. The unfavorable course of the disease leads to a rapid loss of vision. In the advanced stage, optic nerve atrophy is irreversible. If the pathology is not treated, the consequences can be sad: the pressure on the brain will increase, its tissues will begin to shift, which will inevitably lead to death.

    Causes of sinus bradyarrhythmia, treatment methods

    Sinus bradyarrhythmia is a disease that occurs in all age categories of patients and is characterized by a significant decrease in the number of heartbeats. In a healthy person, the pulse rate fluctuates within beats per minute. With this pathology of the heart, the indicators can vary from 40 to 59 contractions, in extremely severe cases, bordering on the risk of an extensive cerebral infarction, from 30 to 39.

    What causes bradyarrhythmia?

    Sinus bradyarrhythmia is divided into two types: moderate and severe, depending on the main indicators of the pulse. In the first case, the heart rate does not fall below 50 beats, in the second - below 40. Often, moderate bradyarrhythmia can also occur in people who regularly play sports and be a normal physiological phenomenon due to the adaptation of the cardiovascular system to constant stress.

    Despite the fact that during a standard medical examination, a person suffering from a low heart rate looks quite normal, there is still a direct threat to his health. What is sinus bradyarrhythmia? First of all, this is hypoxia of all internal organs and vital systems, including the brain. The main danger lies in the fact that the heart does not cope with its task and a sharply reduced pulse can lead to clinical death, for example, in a dream.

    The sinus node is responsible for the frequency of contractions and rhythm, its damage of a degenerative and inflammatory nature leads to depression of cardiac activity. The appearance of sinus bradyarrhythmia in children is due to increased tone of the vagus nerve due to pathological changes in the myocardium. In addition, factors provoking the onset of the disease in infants and adolescents can be:

    • hypothermia (usually in infants and children under three years of age);
    • intracranial hypertension;
    • transferred viral and infectious diseases with complications;
    • genetic predisposition;
    • hormonal disorders (usually in adolescents);
    • angina, pneumonia.

    Medications that affect heart rate can disrupt the automation of sinus rhythm. In adults, the causes of bradyarrhythmia can be:

    • severe atherosclerosis;
    • previous myocardial infarction or stroke;
    • inflammatory changes in the tissues of the heart;
    • obesity of the second and third degree;
    • sedentary lifestyle;
    • vascular thrombosis;
    • cardiosclerosis (most common in older people);
    • cardiac ischemia;
    • hypothyroidism;
    • infectious and viral diseases.

    In addition to the above reasons, arrhythmia is often found in various pathologies of the thyroid gland, vegetovascular dystonia and diseases of the gastrointestinal tract.

    Diagnostics

    During a medical examination, the type of bradyarrhythmia can be established, which can be physiological and organic. Sinus bradycardia belongs to the class of this pathology, therefore, this diagnosis often appears in the conclusions of a medical examination. At the same time, a reduced level of heart rate is observed, but sinus rhythm is maintained. Bradycardia is most often found in athletes.

    If a child or adult has the characteristic symptoms of bradyarrhythmia, and the measurement of the pulse rate gave below normal values, you should immediately seek medical help. In case of a critical drop in heart rate, it is necessary to call an ambulance. In stationary conditions, an electrocardiogram will be performed. If it shows a clear violation of the heart rhythm and prolonged intervals between ventricular contractions, the patient is hospitalized. Then he will have to undergo ultrasound diagnostics of the heart, repeated ECG and daily monitoring of blood pressure jumps. After identifying the type of bradyarrhythmia, treatment will be prescribed appropriate to the diagnosis.

    Symptoms of the disease

    Sometimes people with a moderate form of bradyarrhythmia can live their whole lives without noticing its presence, since it manifests itself only in the form of a slightly lowered heart rate. A pronounced degree of pathology is accompanied by the following conditions:

    • prostration;
    • dizziness;
    • darkening in the eyes
    • distraction;
    • loss of coordination;
    • decreased visual acuity;
    • cold sweat;
    • BP jumps.

    With a sharp decrease in heart rate, blood pressure can drop to a critical level, which will cause arrhythmic shock. In some cases, there is an abrupt cessation of blood circulation, which leads to involuntary emptying of the bladder and intestines.

    Sinus bradyarrhythmia in a child is most often detected by chance, since it rarely has a pronounced clinical picture. But in severe cases, there may be:

    • sudden loss of consciousness;
    • blurred vision;
    • chest pain;
    • chronic fatigue, lethargy;
    • lack of appetite.

    If during inhalation the heart rate increases, and on exhalation the heart rate slows down sharply, this indicates the presence of respiratory bradyarrhythmia. If you hold your breath, its signs should disappear. If this does not happen, then this is not a respiratory sinus bradyarrhythmia.

    Is it possible to play sports and serve in the army with bradyarrhythmia?

    Sinus bradyarrhythmia has its own ICD code (International Classification of Diseases) - R00.1 and refers to pathologies that are divided into physiological and organic. If the disease does not have pronounced symptoms and is the norm for a particular person (with good physical fitness), then he will be drafted into the army. If during the medical examination it was proved that bradyarrhythmia is organic (is the result of serious disorders in the body), then the conscript is released from military duty.

    With this disease, classes that involve moderate cardio loads (for example, running) are not forbidden, but strength training should be abandoned.

    Treatment

    Sinus bradyarrhythmia in adolescents in most cases does not require treatment, as it does not have pronounced symptoms and is a consequence of hormonal imbalance, characteristic of adolescence. In other cases, with moderate bradyarrhythmia, general strengthening drugs are prescribed in the form of tinctures and vitamin complexes.

    With a pronounced form of the disease, a person is hospitalized and prescribed drugs that accelerate the conduction of the heart (for example, Nifedipine). "Prednisolone", "Eufillin", the hormone dopamine, atropine and adrenaline are administered intravenously.

    If the heart rate is below 20, then urgent resuscitation measures are required. With constant fainting, a pacemaker is installed by doctors through a simple surgical operation. But it is used only in critical situations, when no other drugs can stop bradyarrhythmia attacks.

    Forecast

    If organic bradyarrhythmia is not treated, then clinical death may occur due to sudden cardiac arrest. Also, this disease provokes the development of thromboembolism, which in turn leads to heart attack and stroke.

    With physiological bradyarrhythmia (for example, in athletes or in adolescence in children), the pathology has a favorable prognosis, since in most cases it does not have any effect on the cardiovascular and other body systems.

    Intracranial hypertension: ICD code 10

    The name of the disease consists of two Greek words "over" and "tension". It is characterized by an increase in intracranial pressure.

    The human brain controls all the functions of the body and needs reliable protection, which is provided from the outside by the cranium, and from the inside by cerebral fluid, called cerebrospinal fluid. It consists of 90% water, 10% protein inclusions and cellular substance in equal proportions. Its composition and consistency are similar to blood plasma. Liquor washes the brain and serves as a shock absorber that protects against bruises, concussions and other mechanical damage.

    Description

    Since the skull is a limited space in which the brain and the fluid surrounding it are located, a certain pressure is created in it. Normally, it in newborns is from 1.5 to 6 mm of the water column. For children under the age of 2 years - 3-7 mm. In adults, it is kept in the range from 3 to 15 mm.

    Intracranial hypertension ICD code 10 is a disease that is diagnosed when the pressure level rises to 200 mm of water column.

    It can increase with hyperproduction of cerebrospinal fluid, poor absorption of cerebral fluid, for reasons that prevent normal outflow, the presence of tumors and edema.

    All-Russian classifiers

    The international classifier in Russia was introduced in 1999, its revision is planned for 2017.

    According to the current ICD, benign intracranial hypertension is defined as a complex of polyetiological symptoms, which is caused by an increase in ICP in the absence of pathological neoplasms and signs of hydrocephalus.

    Classifiers international

    According to ICD 10, the disease received the following classification codes:

    • G2 benign intracranial hypertension.
    • G2 ICH after ventricular bypass.
    • G 6 - cerebral edema.

    Symptoms and signs

    For the timely initiation of therapy for intracranial hypertension, it is important to recognize the disease. To do this, you need to understand how it flows, what it is characterized by, what to look for.

    Symptoms vary between children and adults.

    The difficulty in determining the signs of the disease in infants is that the child cannot express his complaints. In such a situation, parents should carefully monitor the behavior of the baby. If the baby has the following signs, then we are talking about intracranial hypertension.

    • Frequent vomiting not related to eating.
    • Intermittent sleep.
    • Anxiety, crying and screaming for no apparent reason.
    • Swollen fontanelles without pulsation.
    • Muscular hypertonicity.
    • An increase in the size of the head, protrusion of the forehead.
    • Divergence of the cranial sutures.
    • Syndrome, the so-called setting sun.
    • Visualization of veins on the head.
    • Delay in development from age norms.

    In children from 1 to 2 years old, the process of overgrowth of fontanelles stops, which leads to more pronounced symptoms. Gushing vomiting, fainting, convulsions are observed.

    At the age of over 2 years, the child may complain of a headache, they feel pressure in the eye area from the inside of the skull. The patient has impaired tactile sensations, odor perception, reduced vision, impaired motor function.

    In addition, intracranial hypertension is accompanied by endocrine disorders, obesity, and diabetes mellitus.

    In adult patients, intracranial hypertension is characterized by the presence of the following symptoms:

    • Attacks of severe headache, which is worse in the evening hours.
    • Nausea.
    • Irritability.
    • Fatigue on light exertion.
    • Dizziness and faintness.
    • Dark circles under the eyes.
    • Increased sweating so-called hot flashes.
    • The pupils do not react to light.

    This condition needs to be treated.

    Diagnostics

    Before prescribing therapy, it is necessary to conduct a thorough examination of the patient and establish the causes of intracranial hypertension, since in some cases effective therapy is not possible without eliminating the underlying causes.

    Diagnosis of ICH is carried out using modern methods of hardware research, these are encephalography, neurosonography, Doppler, CT and MRI. In addition, consultations are held with a neurologist and an ophthalmologist.

    Treatment

    Therapy is carried out in several ways:

    • Medication, which consists in the appointment of diuretics to remove fluid from the body. The use of sedatives, painkillers, neuroleptic and nootropic drugs, vitamins.
    • The surgical method allows you to divert the cerebrospinal fluid or free up paths for its withdrawal.
    • Non-drug therapy involves adherence to a salt-free diet and drinking regimen. A complex of exercise therapy, acupuncture, massage is prescribed.

    In addition, symptomatic therapy is carried out to reduce pain and associated symptoms.

    Preparations

    In the treatment of ICH, the following medicines are used: levulose, caffetamin, sorbilact, mannitol.

    G93.2 Benign intracranial hypertension

    ICD-10 diagnosis tree

    • g00-g99 class vi diseases of the nervous system
    • g90-g99 Other disorders of the nervous system
    • g93 other brain lesions
    • G93.2 Benign intracranial hypertension(Selected ICD-10 diagnosis)
    • g93.1 anoxic brain injury, not elsewhere classified
    • g93.3 Fatigue syndrome after a viral illness
    • g93.4 Encephalopathy, unspecified
    • g93.6 cerebral edema
    • g93.8 other specified lesions of brain
    • g93.9 brain injury, unspecified

    Diseases and syndromes related to ICD diagnosis

    Titles

    Description

    Symptoms

    Objective signs of intracranial hypertension are edema of the nipples of the optic nerves, increased pressure of the cerebrospinal fluid, typical x-ray changes in the bones of the skull. It should be borne in mind that these signs do not appear immediately, but after a long time (except for an increase in the pressure of the cerebrospinal fluid).

    With a significant increase in intracranial pressure, a disorder of consciousness, convulsive seizures, and visceral-vegetative changes are possible. With dislocation and wedging of the brain stem structures, bradycardia, respiratory failure occur, the reaction of the pupils to light decreases or disappears, and systemic arterial pressure rises.

    Causes

    With cerebral edema, an increase in the volume of brain tissue occurs and, accordingly, intracranial hypertension develops. Obstruction of the cerebrospinal fluid pathways causes a violation of the outflow of cerebrospinal fluid from the cranial cavity, its accumulation (obstructive hydrocephalus) and, accordingly, intracranial hypertension. Intracranial hemorrhage with hematoma formation also leads to increased intracranial pressure.

    With an increase in intracranial pressure in one of the areas of the skull, a distension area appears, which leads to a displacement of the brain structures relative to each other - dislocation syndromes develop. This pathology is life-threatening and can lead to the death of the patient.

    The most common dislocation syndromes are:

    * displacement of the cerebral hemispheres under the falciform process,.

    * displacement of the cerebellar tonsils in the foramen magnum.

    With an increase in the pressure of the liquor to 400 mm of water. (about 30 mm) possible arrest of cerebral circulation and the cessation of the bioelectric activity of the brain.

    Benign intracranial hypertension in children

    RCHD (Republican Center for Health Development of the Ministry of Health of the Republic of Kazakhstan)

    Version: Clinical protocols of the Ministry of Health of the Republic of Kazakhstan

    general information

    Short description

    Expert Commission on Health Development

    Benign intracranial hypertension is a polyetiological symptom complex caused by an increase in intracranial pressure in the absence of signs of mass formation or hydrocephalus.

    Protocol name: Benign intracranial hypertension in children

    Abbreviations used in the protocol:

    Date of protocol development: 2014.

    Users of the protocol: pediatric neuropathologist, pediatrician and general practitioner, emergency and emergency physicians.

    Classification

    Classification by etiological factors

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