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The magical effect of coffee on the body helps fight fatigue, lethargy, absent-mindedness. It’s not worth getting carried away with it, because with an overdose positive influence substances will be replaced by negative ones, which will affect the well-being of a person. Some people prefer to take caffeine tablets instead of a drink.

What is caffeine sodium benzoate

These tablets are an aphrodisiac and psychostimulant derivative of methylxanthine. The action of caffeine benzoate is to inhibit PDE (phosphodiesterase enzymes) in the heart, organs, nervous system and adipose tissue. When used in large doses ah, the substance can accumulate in the body in the form of cGMP, cAMP (derivatives of adrenaline). The drug is synthetic, based on caffeine, extracted from coffee seeds and tea leaves.

Caffeine is produced in tablets of 100 mg, in a package of 6-10 pcs. A small dosage of the drug has a stimulating effect on the central nervous system, but in case of an overdose, on the contrary, it depresses it. After taking caffeine, a person’s breathing becomes faster, deeper, blood vessels expand, tone increases. cerebral arteries. This tool has the following effects on the human body:

increases concentration;
activates fat burning, therefore suitable for weight loss;
improves mood;
increases mental excitability;
stimulates the release of adrenaline into the blood;
increases muscle activity in athletes, maintains the potential of muscle membranes, participates in calcium metabolism.

Caffeine sodium benzoate: instructions for use

You can drink caffeine tablets with or without food during the day. It is not recommended to use them right before bedtime, because it will make it difficult to fall asleep. The manufacturer recommends using the following dosage options:

For vivacity, raising the efficiency of adults and adolescents, 2-3 doses of 50-100 mg are enough. Children do not need the drug in these cases.
To eliminate a headache, people over 12 need to drink 50-100 mg of the drug 2 times a day for 3 days.
To increase the pressure, children after 12 years of age and adults are recommended to drink 100 mg of caffeine in tablets three times a day.

For any reason, taking the drug should not exceed a single dose of caffeine of 300 mg and a daily dose of 1000 mg. In cases of overdose, a person may experience the following symptoms:

nausea;
dizziness;
restlessness, tremor;
cardiopalmus;
confusion.

How to take blood pressure pills

Caffeine tablets are prescribed for minor and irregular deviations in blood pressure (blood pressure) to normalize the indicator. The drug is a strong psychostimulant, so it should be taken strictly in the allotted doses. The active substance is able to influence vascular and cardiac receptors, which allows you to quickly raise blood pressure to normal. To get this effect, you need to take 50-100 mg of caffeine in tablets 3 times a day for several weeks.

Who should not take caffeine tablets?

Use the product carefully so as not to harm your body and instead positive effect don't get negative. Caffeine is contraindicated for people who:

serious illness of cardio-vascular system;
paroxysmal tachycardia;
allergy or intolerance to caffeine;
sleep disorders;
anxiety disorders;
age up to 12 years;
elevated BP.

With this drug, you need to be careful in the elderly, prone to seizures, spasms or convulsions, epilepsy and eye diseases. During pregnancy and breastfeeding, tablets can only be taken as directed by a doctor. If you combine oral contraceptives with caffeine, it will have less activity, accumulate in the blood, and be slowly excreted by the liver.

Is caffeine effective for weight loss

According to people, the dosage used for stimulation nervous system, insufficient to start the process of fat burning. Caffeine in diet pills is required in large quantities. Athletes with overweight before training, use 10-20 mg of the substance for each kilogram of body weight. It is believed that this is the only way to speed up metabolic processes and heart function to desired indicator. The tablet should be taken 30 minutes before class. Doctors recommend that you start drinking caffeine sodium benzoate for weight loss at 2mg/kg and gradually increase the dosage.

Should You Take Energy Pills?

Many athletes are looking for additional sources of energy for training. For this, there is a special sports nutrition that costs a lot of money, but you can find an easier option - caffeine-benzoate tablets. After taking it, a person activates and increases the temperature, metabolic rate, sweating. This contributes to the growth of endurance, strength.

The action of such a stimulant is directed to the nervous system, it mobilizes free fatty acid. All neurons after taking caffeine will send signals from the brain to the muscles. Some consider the drug a drug, but this is not so, coffee does not cause addiction. For a bodybuilder, it is considered the optimal dosage - 9 mg per 1 kg of body weight, but some athletes drink 15-20 mg / kg.

Are concentration pills good?

People engaged in active mental activity sometimes notice that a tired brain is not able to correctly solve the tasks assigned to it. There is a need for additional stimulation of neurons, relieving fatigue, sometimes headaches. Coffee is often used for this, but the drink can be Low quality. In addition, it has been proven that soluble varieties in large quantities have Negative influence on the intestines, stomach.

The way out will be caffeine pills, which will not increase IQ and will not make a person smarter, but will help to concentrate, activate mental activity. This method gives a short-term effect. You should not get carried away with taking caffeine tablets, in case of an overdose, in addition to side effects the person may become irritable.

Where to buy and how much caffeine tablets cost

Today, pharmacies sell caffeine. You can buy it without a prescription, the cost is from 30 to 60 rubles. You can order the drug via the Internet with home delivery for an additional fee. Online stores also sell pills. sports nutrition, offering them as an additional stimulant for intense training. These drugs are produced famous brands, are produced in packs of 90 tablets, and they cost from 400 rubles. There is not much difference in action, the difference is only in quantity.

Video

Caffeine: instructions for use and reviews

Caffeine is a psychoactive drug.

Release form and composition

Caffeine comes in the form of a solution for subcutaneous injection: transparent, colorless or slightly colored (in ampoules of 2 ml, 5 ampoules in blister packs, 2 packs in a carton box; 5 or 10 ampoules in a carton box with partitions or bars).

The composition of 1 ml of solution includes:

The active substance is caffeine-sodium benzoate 100 or 200 mg;
Auxiliary components: sodium hydroxide solution 0.1M - up to pH 6.8-8.5, water for injection - up to 1 ml.

Pharmacological properties

Pharmacodynamics

Caffeine is a central adenosine receptor antagonist and stimulates the centers medulla oblongata: respiratory, vasomotor and vagal. It also activates the central nervous system and respiratory system, improves the functions of skeletal muscles, the production of hydrochloric acid and pepsin in the gastrointestinal tract, promotes the processes of glycogenolysis. Caffeine increases sensitivity respiratory center to the stimulating effect of carbon dioxide, increasing alveolar ventilation. The substance increases the frequency and intensity of heart contractions, as well as the minute volume of the heart (it has a positive chronotropic effect on the sinoatrial node and a positive inotropic effect on the myocardium).

Caffeine is characterized by diuretic and hypertensive effects, reduces uterine contractility and promotes vasoconstriction of the brain.

Pharmacokinetics

Caffeine binds to plasma proteins by approximately 25–36%. Its biotransformation is carried out in the liver. In adult patients, 80% of caffeine is metabolized to paraxanthine (1,7-dimethylxanthine), 10% to theobromine (3,7-dimethylxanthine), and 4% to theophylline (1,3-dimethylxanthine). These compounds are demethylated to monomethylxanthines and then to methylated uric acid derivatives. In premature babies, caffeine is formed from theophylline. The half-life is 3–7 hours, in newborns it is extended to 65–130 hours (a decrease to the level of an adult patient occurs at 4–7 months). The maximum concentration is established 50–75 minutes after the substance enters the body.

Caffeine is excreted in the urine as metabolites (1-2% unchanged). In neonates, it is also excreted via the kidneys, with 85% of the dose being excreted unchanged.

Indications for use

Decreased physical and mental performance;
Moderate arterial hypotension;
muscle weakness;
Migraine;
Drowsiness;
Respiratory depression (including with mild poisoning with opioid analgesics and hypnotic drugs, carbon monoxide, with asphyxia of newborns, to restore the required level of pulmonary ventilation after the use of general anesthesia).

Contraindications

Organic diseases of the cardiovascular system (including acute infarction myocardium, atherosclerosis);
Arterial hypertension;
sleep disorders;
Glaucoma;
Paroxysmal tachycardia;
Increased excitability;
Epilepsy and tendency to convulsive seizures;
Frequent ventricular extrasystole;
Elderly age;
Pregnancy and lactation;
Hypersensitivity to the components of the drug.

Instructions for use Caffeine: method and dosage

Caffeine solution is administered subcutaneously.

Adults are usually prescribed 1 ml of a 100 mg / ml or 200 mg / ml solution. Maximum dose is: single - 400 mg, daily - 1000 mg.

Children, depending on age, are usually prescribed 0.25-1 ml of a 100 mg / ml solution of Caffeine.

The frequency and duration of use are determined by the doctor.

Side effects

According to the instructions, Caffeine can cause the following side effects:

Central nervous system: tachypnea, sleep disturbance, tremor, agitation, anxiety, headache, convulsions, dizziness;
Cardiovascular system: heart rhythm disturbance, tachycardia, increased blood pressure;
Digestive system: nausea, diarrhea, vomiting, exacerbation of peptic ulcer.

With prolonged use, slight addiction is possible (a decrease in action is associated with the formation of new adenosine receptors in brain cells).

Overdose

Signs of an overdose of caffeine are trembling of the whole body, observed in newborns, pain in the stomach or abdomen, nausea and vomiting, sometimes with spotting, vomiting or bloated belly in newborns, palpation of which is accompanied by painful sensations, increased pain or tactile sensitivity, dehydration, frequent urination, arrhythmia, tachycardia. Taking the drug in very high doses can lead to CNS symptoms such as headache, clouded consciousness or delirium, restlessness or agitation, anxiety, agitation, irritability, tremor or muscle twitching, photopsia, tinnitus, or sensation of other sounds, sleep disturbances, epileptic seizures(mainly clonic-tonic convulsions) in acute overdose.

Recommended as a treatment symptomatic therapy. If caffeine has been taken in the last 4 hours, its dose exceeded 15 mg / kg, and there was no vomiting provoked by this drug, gastric lavage should be performed. It is also recommended to take activated carbon and laxatives, and hemorrhagic gastritis- gastric lavage with ice-cold 0.9% sodium chloride solution and administration of antacids. If necessary, carried out artificial ventilation lungs and oxygenation. For epileptic seizures, phenytoin, phenobarbital, or diazepam is given intravenously. You should also maintain water and electrolyte balance. Hemodialysis is often effective in case of overdose, and in newborns, if necessary, exchange transfusion blood.

special instructions

During the use of Caffeine, it must be taken into account that the sudden cessation of therapy can lead to increased inhibition of the central nervous system in the form of drowsiness and depression.

The impact on the central nervous system can be manifested both by excitation and inhibition of the higher nervous system.

Use during pregnancy and lactation

According to the FDA recommendations, caffeine belongs to category C. It increases the risk of spontaneous abortions, provokes delays intrauterine development and the occurrence of arrhythmia in the fetus (when administered to pregnant women in high doses). The results of animal experiments have shown that with the introduction of doses equivalent to the content of caffeine in 12-24 cups of coffee drunk per day, throughout pregnancy or with a single administration of very high doses (50-100 mg / kg), skeletal developmental disorders are observed (as fingers, and individual phalanges) of the fetus. With the intake of caffeine in the body of a pregnant female in smaller doses, a slow development of the fetal skeleton was noted.

The caffeine enters breast milk(its amount is approximately 1% of the concentration in the mother's blood plasma). If a nursing mother receives this substance in an amount equivalent to 6-8 cups of caffeinated drinks per day, the child may develop insomnia and hyperactivity.

drug interaction

At simultaneous application Caffeine with certain medicines may cause the following effects:

Narcotic and sleeping pills: decrease in their efficiency;
Non-narcotic analgesics and ergotamine: increasing their effectiveness (due to increased absorption);
Cardiac glycosides: enhancing their action and increasing toxicity.

Analogues

Analogue of Caffeine is Caffeine-sodium benzoate.

Terms and conditions of storage

Keep out of the reach of children at temperatures up to 25 °C.

Shelf life - 5 years.

Dosage form: solution for subcutaneous and subconjunctival administration Compound:

Active substance:

Caffeine-sodium benzoate in terms of dry matter - 100 mg or 200 mg.

Excipients: water for injection - up to 1 ml.

Description: Clear colorless or slightly colored liquid. Pharmacotherapeutic group:Psychostimulant ATX:

N.06.B.C.01 Caffeine

Pharmacodynamics:

Caffeine is methylxanthine, which has a psychostimulant and analeptic effect. Competitively blocks central and peripheral Ai and A 2 adenosine receptors. Inhibits the activity of phosphodiesterase in the central nervous system, heart, smooth muscle organs, skeletal muscle ah, adipose tissue. Stimulates the centers of the medulla oblongata (respiratory and vasomotor), has a direct stimulating effect on the cerebral cortex. In high doses, it facilitates interneuronal conduction in the spinal cord, enhancing spinal reflexes.

Increases mental and physical performance, stimulates mental activity, motor activity, shortens reaction time, temporarily reduces fatigue and drowsiness. In small doses, the effect of stimulation prevails, and in large doses, the effect of depression of the nervous system.

Accelerates and deepens breathing, stimulates the vasomotor center and has a direct relaxing effect on vascular wall, which leads to the expansion of the vessels of the heart, skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the vessels of the brain, which is accompanied by a decrease in brain bloodflow and pressure of oxygen in the brain). Arterial pressure changes under the influence of vascular and cardiac mechanisms of caffeine influence: at normal initial arterial pressure it does not change or slightly increases it, at arterial hypotension it normalizes.

Has an antispasmodic effect on smooth muscle(including bronchodilating effect), on the striated - stimulating. Increases the secretory activity of the stomach and diuresis (decrease in the reabsorption of sodium and water ions in the proximal and distal renal tubules, as well as vasodilatation of the kidneys and increased filtration in the renal glomeruli).

Reduces platelet aggregation and histamine release from mast cells. Increases basal metabolism: increases glycogenolysis, increases lipolysis.

Pharmacokinetics:

It is rapidly distributed in all organs and tissues of the body: it easily penetrates the blood-brain barrier and the placenta. The volume of distribution in adults is 0.4-0.6 l / kg, in newborns - 0.78-0.92 l / kg. Communication with blood proteins - 25-36%. Metabolism in the liver is more than 90%, in children of the first years of life up to 10-15%. In adults, about 80% of a dose of caffeine is metabolized to paraxanthine, about 10% to theobromine, and about 4% to. These compounds are subsequently demethylated to monomethylxanthinates and then to methylated uric acids. The half-life in adults is 3.9-5.3 hours (sometimes up to 10 hours), in newborns (up to 4-7 months of life) - 65-130 hours. Excretion of caffeine and its metabolites is carried out by the kidneys (unchanged in adults are excreted 1-2%, in newborns - up to 85%).

Indications:

Decreased mental and physical performance, drowsiness, headache of vascular origin (including migraine), moderate arterial hypotension, respiratory depression (including with mild poisoning narcotic analgesics and hypnotic drugs, carbon monoxide, neonatal asphyxia), restoration of pulmonary ventilation after the use of general anesthesia.

Ciliochoroidal detachment in adults.

Contraindications:

Hypersensitivity (including to other xanthines), anxiety disorders, severe arterial hypertension, organic diseases cardiovascular system (including acute myocardial infarction, atherosclerosis), paroxysmal tachycardia, frequent ventricularextrasystoles, sleep disturbances, childhood up to 18 years (for subconjunctival administration).

Carefully:

Use with caution in glaucoma, irritability, in old age, with epilepsy and a tendency to convulsive seizures.

Pregnancy and lactation:

Overuse medicinal product during pregnancy can lead to spontaneous abortions, slowing of intrauterine development of the fetus, arrhythmias in the fetus; possible violations of the development of the skeleton when using large doses and slowing down the development of the skeleton against the background of lower doses.

The drug passes into breast milk in small amounts, but accumulates in infants and can cause hyperactivity and insomnia. At the time of treatment with the drug should stop breastfeeding.

Dosage and administration:

Caffeine-sodium benzoate is used subcutaneously and subconjunctivally.

Doses of the drug are selected individually. Higher doses for adults (under the skin): single 0.4 g, daily 1 g. Adults, 1 ml of a 10-20% solution (100-200 mg); children (depending on age) - 0.25-1.0 ml of a 10% solution (25-100 mg).

In ophthalmic practice, a 10% solution of 0.3 ml is administered subconjunctivally once a day (30 mg). The number of injections depends on intraocular pressure and depth of the anterior chamber.

Side effects:

From the side of the nervous system: agitation, anxiety, tremor, restlessness, headache, dizziness, epileptic seizures, increased reflexes, tachypnea, tinnitus, insomnia; with sudden cancellation - increased inhibition of the central nervous system, fatigue, drowsiness, muscle tension.

From the side of the cardiovascular system: palpitations, tachycardia, arrhythmias, increased blood pressure.

From the side digestive system : nausea, vomiting, exacerbation of peptic ulcer.

Other : nasal congestion, with prolonged use - addiction, drug dependence; with subconjunctival administration - short-term pain, slight local edema with possible appearance single petechiae.

Overdose:

Symptoms : gastralgia, agitation, anxiety, agitation, restlessness, confusion, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, tremor or muscle twitching; nausea and vomiting; ringing in the ears, epileptic seizures.

In newborns (including preterm infants), at a plasma caffeine concentration of 50 mg / ml, toxic effects: restlessness, tachypnea, tachycardia, tremor, painful distended abdomen or vomiting, increased Moro reflex, with more high concentrations- convulsions.

Treatment: maintenance of lung ventilation and oxygenation; with epileptic seizures - intravenously, or phenotoin; maintaining fluid and salt balance. Hemodialysis, in newborns, if necessary, exchange blood transfusion.

Interaction:

Reduces the effect of sleeping pills and drugs, increases (improving bioavailability) - acetylsalicylic acid, paracetamol and other non-narcotic analgesics, increases the excretion of lithium preparations in the urine. Joint application drug with beta-blockers can lead to mutual suppression therapeutic effects. Accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.

special instructions:

It should be borne in mind that the sudden discontinuation of the drug may lead to increased inhibition of the central nervous system (drowsiness, depression). The effect on the central nervous system depends on the type of nervous system and can be manifested both by excitation and inhibition of higher nervous activity.

Due to the fact that the effect of caffeine on arterial pressure consists of vascular and cardiac components, as a result, both the effect of stimulating the heart and oppression (weak) of its activity can develop.

Sleep apnea in newborns and children infancy in postoperative period(prevention) is used or caffeine citrate, but not sodium benzoate.

Do not take before bed.

Influence on the ability to drive transport. cf. and fur.:

Given the side effects of the drug during the treatment period, care must be taken when administering vehicles, occupation by other potensocially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions.

Release form / dosage:

Solution for subcutaneous and subconjunctival administration 100 mg/ml and 200 mg/ml.

Package:

1 ml or 2 ml in neutral glass ampoules. 10 ampoules together with a knife for opening ampoules or an ampoule scarifier and instructions for use in a cardboard box. 5 ampoules in a blister pack made of PVC film and printed aluminum foil lacquered or without foil. 2 blister packs together with instructions for use and a knife for opening ampoules or an ampoule scarifier in a pack of cardboard. When using ampoules with notches, rings and dots, an ampoule scarifier or a knife for opening ampoules is not inserted.

Storage conditions:

At temperatures from 15 to 25 °C.

Keep out of the reach of children.

Best before date:

5 years.

Do not use after the expiration date.

Conditions for dispensing from pharmacies: On prescription Registration number: LS-000493 Date of registration: 05.05.2010 / 27.12.2012 Expiration date: Perpetual Registration certificate holder:DALHIMFARM JSC Russia Manufacturer: Information update date: 21.01.2018 Illustrated Instructions

In this article, you can read the instructions for using the drug Caffeine. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of medical specialists on the use of Caffeine in their practice. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Caffeine analogs, if available structural analogues. Use for treatment reduced pressure(hypotension), spasms and drowsiness in adults, children, as well as during pregnancy and lactation.

Caffeine- psychostimulant and analeptic. It has a stimulating effect on the central nervous system, mainly on the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces drowsiness, fatigue. Weakens the effect of drugs that depress the central nervous system. It has a pronounced effect on the cardiovascular system: it increases the strength and frequency of heart contractions, increases blood pressure during hypotension. Renders moderate diuretic action. Increases the secretion of the glands of the stomach.

Indications

diseases accompanied by depression of the central nervous system, functions of the cardiovascular and respiratory systems(including poisoning with opioid analgesics, infectious diseases);
spasms of cerebral vessels;
decrease in mental and physical performance;
drowsiness.

Release forms

Solution for subcutaneous administration.

Tablets 100 mg Caffeine sodium benzoate.

Instructions for use and dosage

Administered subcutaneously or taken orally. Adults - 100-200 mg 2-3 times a day; children - 25-100 mg 2-3 times a day.

Side effectvie

sleep disturbance;
excitation;
anxiety;
with prolonged use, addiction is possible;
tachycardia;
increase in blood pressure;
arrhythmias;
nausea, vomiting.

Contraindications

arterial hypertension;
organic diseases of the cardiovascular system (including severe atherosclerosis);
glaucoma;
increased excitability;
sleep disorders;
old age.

special instructions

Can be used as mono- or as part of combination therapy.

drug interaction

With simultaneous use, the effect is reduced sleeping pills and drugs for anesthesia.

With simultaneous use, it is possible to enhance the action of antipyretic analgesics, salicylamide, naproxen.

With the simultaneous use of estrogens ( hormonal contraceptives, means for HRT) it is possible to increase the intensity and duration of the action of caffeine due to the inhibition of the CYP1A2 isoenzyme by estrogens.

With the simultaneous use of adenosine, caffeine reduces increased heart rate and changes in blood pressure caused by adenosine infusion; reduces vasodilation due to the action of adenosine.

With simultaneous use, it is possible to increase the bioavailability, absorption rate and plasma concentration of acetylsalicylic acid.

With simultaneous use, mexiletine reduces the clearance of caffeine and increases its plasma concentrations, apparently due to the inhibition of caffeine metabolism in the liver by mexiletine.

Methoxsalen reduces the excretion of caffeine from the body with a possible increase in its effect and the development of a toxic effect.

Due to the induction of microsomal liver enzymes under the influence of phenytoin, with its simultaneous use, the metabolism and excretion of caffeine are accelerated.

Fluconazole and terbinafine cause a moderate increase in the concentration of caffeine in the blood plasma, ketoconazole is less pronounced.

The most pronounced increase in AUC and a decrease in clearance are observed with the simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemidic acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin.

With simultaneous use, caffeine accelerates the absorption of ergotamine.

Analogues of the drug Caffeine

Structural analogues according to active substance:

Dia-Activad-N;
Caffeine anhydrous;
Caffeine-sodium benzoate.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Clear colorless or slightly yellowish liquid.

Pharmacotherapeutic group

Psychostimulants and nootropics. xanthine derivatives.

ATX code N06BC01

Pharmacological properties"type="checkbox">

Pharmacological properties

Pharmacokinetics

The drug is rapidly distributed in all organs and tissues of the body. Communication with blood proteins (albumins) - 25-36%. It easily crosses the blood-brain barrier and the placenta. Penetrates into breast milk. The volume of distribution in adults is 0.4-0.6 l / kg, in newborns - 0.78-0.92 l / kg.

More than 90% is metabolized in the liver taken dose drug, in children of the first years of life up to - 10-15%. In adults, about 80% of a dose of caffeine is metabolized to paraxanthine, about 10% to theobromine, and about 4% to

theophylline. These compounds are subsequently demethylated to monomethylxanthines and then to methylated uric acids. The half-life in adults is 3.9-5.3 hours (sometimes up to 10 hours), in newborns (under the age of 4-7 months of life) - 65-130 hours. Caffeine and its metabolites are excreted by the kidneys (1-2% is excreted unchanged in adults, up to 85% in newborns).

Pharmacodynamics

Caffeine is an alkaloid found in tea leaves and coffee beans. Pharmacological properties of the drug are divided into central and peripheral.

The central effects, in turn, are divided into psychostimulating and analeptic. The psychostimulating effect of caffeine-sodium benzoate-Darnitsa is associated with its antagonism to the action of adenosine on purinergic (adenosine) A-1 and A-2 receptors in the central nervous system (CNS). Adenosine is known to depress CNS functions. Under the influence of the drug increases mental activity, mental and physical performance. The psychostimulating effect is directly dependent on the dose. Small doses stimulate the functions of the central nervous system, large doses depress (due to the depletion of nerve cells).

The analeptic effect of caffeine-sodium benzoate-Darnitsa is associated with its effect on the respiratory and hemodynamic centers of the medulla oblongata. As a result, an increase in the frequency and volume of inspiration is observed.

The peripheral effects of the drug are not unambiguous and are associated with its dose and the level of influence on the vascular bed and myocardium. coronary blood flow first increases and then decreases, renal blood flow increases, vessels constrict abdominal cavity, skin. Under the influence of the drug, the central blood circulation worsens and the pressure of the cerebrospinal fluid decreases, which explains its effectiveness in migraine. The effect of the drug on the heart is ambiguous. In small doses, it causes positive inotropic effect, in high doses - positive chronotropic effect. In some people, it can cause tachycardia and even arrhythmia.

Indications for use

Infectious and other diseases that are accompanied by depression of the central nervous and cardiovascular systems

Respiratory depression, asphyxia

Poisoning with drugs and other substances that depress the central nervous system

Asthenic syndrome

Spasms of cerebral vessels

Dosage and administration

For adults, the drug is prescribed subcutaneously at a dose of 1-2 ml of a 10% solution (100-200 mg). Higher single dose– 400 mg maximum daily dose– 1 year

For children over 12 years of age, the drug should be administered subcutaneously at a dose (depending on

age) 0.25-1 ml of 10% solution (25-100 mg).

Side effects"type="checkbox">

Side effects

Agitation, anxiety, tremor, restlessness, insomnia, headache, dizziness, epileptic seizures, increased reflexes, tachypnea. In case of sudden discontinuation of the drug after long-term use- increased influence on the central nervous system, increased fatigue,

drowsiness, muscle tension, depression

Palpitations, chest tightness, tachycardia, arrhythmias, increased blood pressure

Nausea, vomiting, diarrhea, exacerbation of peptic ulcer

Hypersensitivity reactions, including rash, itching, urticaria, angioedema, bronchospasm

Hypo- or hyperglycemia, increased creatinine clearance, increased

excretion of sodium and calcium, false boost urinary concentration

acids in blood plasma, determined by the Bittner method, slight increase concentrations of 5-hydroxyindoleacetic acid, vanillylmandelic acid and catecholamines in urine

Other: increased frequency of urination, nasal congestion,

long-term use - addiction, drug addiction

Contraindications

Hypersensitivity to xanthine derivatives and other components of the drug

Hyperexcitability

Insomnia

Atherosclerosis

Organic diseases of the cardiovascular system, including acute

myocardial infarction

Paroxysmal tachycardia

Arterial hypertension

Glaucoma

Age over 60 years

Pregnancy, lactation

Children's age up to 12 years

Drug Interactions"type="checkbox">

Drug Interactions

When used simultaneously with other drugs

Maybe:

with alpha and beta-agonists, antipyretic analgesics,

clozapine, xanthine derivatives, psychostimulants,

cardiac glycosides, thyrotropicmimeans- enhancing the effects of the above-mentioned drugs;

with anxiolytics, opioid analgesics, hypnotics and sedatives - weakening the effects of the above-mentioned drugs;

With antiarrhythmic drugs(mexiletin), hormonal oral contraceptives, disulfiram, enoxacin, erythromycin,

isoniazid, methoxsalen, norfloxacin, ofloxacin, cimetidine,

ciprofloxacin- enhancing the effects of caffeine;

with antidepressants, barbiturates,beta- adrenoblockers, primidone, anticonvulsants(hydantoin derivatives, especially phenytoin), cholestyramine, anticholinergics– weakening the effects of caffeine;

with drugs, stimulantsmicentral nervous

system, drinks containing caffeine- over-stimulation

central nervous system;

with MAO inhibitors, procarbazine, furazolidone- dangerous arrhythmias or a pronounced increase in blood pressure;

with ergotamine- increased absorption of the latter from the gastrointestinal tract;

with calcium preparations- weakening of the absorption of the latter from the gastrointestinal tract;

with drugamilithium- increased excretion of the latter with urine;

with nicotine- increased urinary excretion of caffeine.

The drug slightly increases the concentration of 5-hydroxyindoleacetic acid when it is determined in the urine.

The drug slightly increases the concentration of catecholamines and

vanillylmandelic acid, which can lead to false positive

test results in the diagnosis of pheochromocytoma and neuroblastoma.

Do not use the drug during tests.

The drug can lead to false results in determining the concentration of urate in the blood serum by the Bittner method.

Caffeine is an adenosine antagonist.

special instructions

The effect on the central nervous system depends on the type of nervous system and can be manifested both by excitation and inhibition of the higher nervous system.

activities.

Due to the fact that the effect of caffeine on blood pressure consists of vascular and cardiac components, it can develop as an effect

stimulation of the heart, and weak inhibition of its activity.

Use with caution in patients peptic ulcer stomach and duodenum history of epilepsy

Apnea in newborns and in infants in the postoperative period (prophylaxis) is treated with caffeine or caffeine citrate, but not

caffeine sodium benzoate.

Children

The drug should not be used in children under 12 years of age.

Pregnancy and lactation

The drug should not be used during pregnancy or lactation.

Features of influence medicinal product on the ability to drive vehicles and potentially dangerous mechanisms

During treatment, care should be taken when driving vehicles and working with other mechanisms, and in case of side effects from the nervous system, refrain from working with potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.