De nol treatment. General characteristics of the drug

How to drink De nol, how effective is it? This question interests those who suffer.

There are many factors that negatively affect human health. Because of malnutrition, frequent stress, lack of sleep a person begins to feel. In this case, De Nol tablets will help to cope with the discomfort.

1 Composition and pharmacokinetics

De Nol is a new generation antibiotic that destroys pathogenic microbes. Produced in the form of oval tablets, coated with a fast-dissolving shell. The main producer is the Netherlands. Well proven protective properties this medicine, which contains bismuth tripotassium dicitrate. The mechanism of action of the drug is as follows: the tablet enters the stomach and the sore spots are covered with a thin film and heal quickly.

As a result, the tissues of the stomach receive protection from the acidic environment, enzymes produced as a result of digestion, bacteria (they become the cause of the progression of gastritis and ulcers). The active substance is completely excreted from the body along with feces and slightly through the kidneys (if bismuth is in the blood plasma).

De Nol is included in the complex treatment regimen. It is prescribed to those patients who have impaired functions gastrointestinal tract, at peptic ulcer stomach and duodenum, gastritis, dyspepsia, syndrome. You can drink de-nol for those who want with low acidity of the stomach, cholecystitis, colitis, and other ailments.

Any disease requires proper treatment, depending on this, the course of treatment, the dosage of the drug are determined.

2 Use in diseases of the stomach

With a stomach ulcer, it makes a person suffer. These harmful microorganisms contribute to the increase in acidity gastric juice. While in the body, they may not show themselves quite long time. Until the immune system fails, which can provoke:

transferred illness;
antibiotic;
avitaminosis;
stressful conditions;
bad habits (alcohol, smoking);
unbalanced diet;
hereditary factors.

Stomach:

constantly tested pain(may intensify in autumn and spring);
vomiting with a sour taste;
heartburn.

With an ulcer, pain usually appears during or after eating. In a hungry state, the stomach calms down. To get rid of discomfort, drink a glass of milk or eat light porridge. Drink to reduce acidity drinking soda, which relieves pain with an ulcer. You can greatly improve your condition if you take De nol, after consulting with your doctor.

The formation of a duodenal ulcer also occurs from exposure to Helicobacter bacteria. The risk group includes:

those in whose family someone suffered from this disease;
drinking a lot of coffee;
heavy smokers;
alcoholics;
those who do not eat properly;
often experiencing nervous strain;
patients with gastritis.

Symptoms of the disease:

stabbing or cutting pain;
nausea, sometimes with vomiting;
bloating or constipation;
loss of appetite.

The doctor will send you for an examination. And if it turns out that the cause of the ulcer is Helicobacter bacteria, then Denol will help solve the problem.

De nol helps with gastritis. With this disease, the mucous membrane of the stomach becomes inflamed, as a result, an imbalance occurs in its work, the digestibility of food is disturbed. As a result, a person loses weight, loses the energy necessary for a full life.

Causes of the disease:

preference for spicy food;
passion for alcoholic beverages;
nervous tension;
lack of diet.

Gastritis makes itself felt with pain when a person goes without food for a long time. Sometimes pain in the abdomen begins to bother after eating. The disease may be accompanied by nausea, vomiting, intestinal disorders.

Symptoms acute form gastritis:

strong pain;
heartburn;
vomiting with mucus;
excessive salivation;
diarrhea or constipation;
chills and high fever;
cardiopalmus;
increased sweating and weakness.

In this case, you should definitely see a doctor who will determine how to take de-nol for gastritis and prescribe a course of treatment.

3 Required dosage

When and in what doses to take Denol is determined by the gastroenterologist. According to the instructions that are attached to the drug, usually adults and children from the age of 14 drink Denola tablets 2 times, 2 pcs. or 4 times 1 pc.

Drink De nol should be half an hour before meals. Eating 3 times a day, the patient drinks 3 tablets before meals before eating, drinks 1 tablet at night. Another option is to take 2 tablets before breakfast and before dinner. The tablet should not be chewed, it should be swallowed with non-carbonated water. Milk, coffee, tea are not suitable for this, as there is a risk negative influence on the effectiveness of the drug.

The duration of treatment depends on the severity of the disease. The course of treatment usually lasts no more than 2 months, after this period the drug should not be taken.

After taking the drug, it is better to suspend the use of other drugs containing bismuth for 2 months.

Overdose is possible if the drug was taken in large doses or for a long time. In this case, the function of the kidneys is impaired. To get rid of the identified symptoms, it is enough to stop the drug.

First aid for overdose - gastric lavage, reception activated carbon and saline laxatives.

In the future, you will need symptomatic therapy. If the examination shows a high level of bismuth in the blood, the doctor will prescribe complex treatment. With a pronounced character resort to hemodialysis. Any manifestation of symptoms of an overdose is a signal for drug withdrawal.

The interaction of Denol with other drugs is not excluded. Half an hour before taking the drug and after half an hour after taking other drugs are not useful. This rule also applies to food and drink. It is recommended at this time not to drink milk, juices, not to eat fruits. This will help to avoid imbalance in the gastrointestinal tract.

If the stomach is treated, they will not be useful sour dishes. Unhealthy food nullify useful action medicines. Therefore, before taking Denol, it is wise to discuss with your doctor what drugs and products you can use during treatment. After all, any great medicine if taken incorrectly, will not give positive result and even harm the body.

4 Contraindications and side effects of the drug

Before you start taking De-nol for gastritis and other ailments, you need to find out who this drug is not suitable for.

You should be wary if there are such factors:

individual intolerance to the drug;
impaired renal function;
During pregnancy and breastfeeding.

Failure to comply with the rules for taking the drug can lead to serious problems with health, and in case of pregnancy there is a threat to normal functioning internal organs future baby. You should not decide on your own how to take the pills. Only a specialist can determine the dosage, taking into account individual characteristics sick. It will also be necessary to find out if there will be problems with the absorption of the drug by the body.

Side effects may appear as allergic reaction and disorders digestive system.

A rash indicates an allergy skin, itching. In this case, you need to see a doctor who will decide to change the dosage downward or suggest another antibiotic. not excluded unpleasant symptoms after taking the medication - nausea, vomiting, frequent stool or constipation. These negative effects will soon pass. If this does not happen, then the medicine is not suitable and you should stop taking it. With prolonged uncontrolled use of the drug, destruction develops nerve cells leading to encephalopathy. The reason is the accumulation of bismuth compounds in the tissues of the nervous system.

Among huge amount drugs presented on Russian market, it is difficult to find means that do not cause side effects. Despite the achievements of modern pharmaceuticals, almost all drugs, even with correct reception and compliance with the dosage, can cause some harm to the patient's body. However, it is impossible to do without medications at all, because in a number of diseases it is required to carry out therapy as quickly as possible.

The list of such problems is quite wide, and diseases of the stomach and duodenum occupy not the last place in it. When making such diagnoses, the doctor usually prescribes a course of treatment with De-Nol. This drug is considered one of the most effective and safe. Of course, this statement is true only if all medical advice issued at the same time as the appointment. However, most patients still have many questions regarding this drug. How many days does the course of treatment with "De-Nol" last for a stomach ulcer? How to take pills correctly? How often to repeat the course "De-Nol"? Is it normal for side effects to occur during treatment? What optimal course"De-Nola" for gastritis?

Judging by the above questions, most often patients are trying to find out details about the duration of treatment. It is this topic that we will cover in the article. Readers will draw from it all the information they are interested in about the course of treatment with De-Nol. We will also briefly describe the drug itself and note all the features of its administration.

General characteristics of the drug

As soon as the doctor, after the treatment, diagnoses the patient with an "ulcer" or "gastritis", he will most likely immediately prescribe a course of treatment with De-Nol. How much to drink pills and how to do it, the doctor usually tells right there in the office, but he does not give a description of the medicine. Although this information is very useful for patients.

So, first of all, it is worth understanding that this drug is one of the most powerful. In addition, it allows you to comprehensively approach the problem, and this already makes it possible to prescribe a simplified scheme and course of treatment. Many patients confuse "De-Nol" and "Omez" with each other, considering them to be equivalent drugs and replacing them with own will. However, this cannot be done, since the tool we are describing is unique in many respects.

How many days the course of treatment "De-Nol" lasts for gastritis and ulcers, we will tell a little later. Now let's find out what this drug is. The drug has both healing and antiseptic properties, which makes it indispensable in the treatment of diseases of the gastrointestinal tract. It also has astringent properties that help the drug to cope with diseases more effectively. In addition, the course of treatment with "De-Nol" relieves the patient of Helicobacter pylori, which is the culprit of peptic ulcer. A huge plus of the drug is the fact that it does not apply to antibiotics. And therefore, will not cause serious side effects inherent in this group of funds.

I would like to mention that even with a long course of taking De-Nol, Helicobacter pylori cannot develop resistance to the drug. The drug is equally effective in primary and re-treatment. Such characteristics are rarely combined in one drug.

Release form of the drug

Before starting a course of treatment with "De-Nol" for gastritis or peptic ulcer, you need to protect yourself from fakes. To do this, you need to study how the tablets should look.

The manufacturer produces the drug only in the form of tablets. They have a biconvex shape and are film-coated. Usually the color of the tablets is close to light cream, but slight deviations towards darker or lighter shades are also allowed.

The pills are very well protected from counterfeiting due to embossing. It is applied on both sides and consists of an inscription and a graphic drawing. Some patients who underwent a course of treatment with De-Nol complained of bad smell coming from pills. Pharmacists note that this is the norm. Original tablets may emit a mild ammonia odor.

The manufacturer packs the drug in cardboard boxes. Each contains several blisters. They contain eight tablets. On average, from seven to fourteen blisters are invested in a pack. Maximum amount tablets in the package - one hundred and twelve.

Depending on the neglect and nature of the course of the disease, the doctor may prescribe both a minimum course of treatment with De-Nol and a maximum course with a possible repetition in a few months. Focusing on this, the patient has the opportunity to calculate in advance which package of tablets he will need.

The composition of the drug and dosage

Often, patients with peptic ulcer and gastritis try to independently compare De-Nol and Omez with each other. Treatment regimens and the course of taking these medications, however, vary greatly. And this is not surprising, because despite the fact that the drugs have similar indications for use, they contain different active ingredients.

"De-Nol" consists of active and additional substances. Bismuth oxide belongs to the first category. It is this substance that provides a wide therapeutic effect which provides the drug. It is in each tablet 120 milligrams.

Auxiliary components are selected and included in the composition of the drug in order to contribute to the rapid absorption of the active substance in the gastrointestinal tract. This group of components includes:

corn starch;
povidone;
magnesium stearate;
potassium polyacrylate.

In addition, it is necessary to mention the components that make up film sheath tablets:

macrogol;
hypromellose.

All excipients are in the drug in small quantities.

Indications for taking tablets

In almost one hundred percent of cases, the doctor prescribes a course of treatment with De-Nol for stomach ulcers and gastritis. However, these are not the only indications for admission. this drug. The list of health problems that pills effectively cope with is quite voluminous:

duodenal ulcer in different stages leaks;
gastroduodenitis;
(including with diarrhea as one of the symptoms);
dyspepsia;
peptic ulcer stomach;
peptic ulcer of the duodenum;
damage to the gastric mucosa.

Most often, the last of these problems occurs with long-term use of non-steroidal anti-inflammatory drugs.

The action of the drug

The spectrum of action of the tablets is quite wide, therefore, with peptic ulcer and gastritis, the course of treatment with De-Nol is so effective. Even after initial appointment the drug forms a protective film that envelops inner walls stomach. At the same time, it very effectively neutralizes Helicobacter pylori.

Parallel medicine contributes to the normalization acid-base balance, improve blood circulation in the stomach, accelerate metabolic processes. It was also noticed that during the treatment process the rate of regeneration of damaged tissues increases.

Doctors say that the already damaged gastric mucosa is actively destroyed by the pepsin produced by the body. Its concentration is significantly reduced after a course of treatment with De-Nol (and Omez, by the way, you can achieve a similar effect).

It is impossible not to mention that the drug acts as a means to strengthen the immune system. It has been proven that a decrease in its activity creates all the conditions for the penetration of Helicobacter pylori into the body. The more reduced the immune system, the more the harmful bacterium penetrates. Initially, it manifests itself as a symptom of gastritis, then it becomes the cause of ulcers on the mucosa. And at this stage, it can already threaten the patient with oncology.

The mechanism of action of tablets on the causative agent of peptic ulcer

From our article, readers have already learned what De-Nol treats. The course of treatment with this drug successfully neutralizes Helicobacter pylori.

The mechanism of action of the drug on this harmful microorganism is quite simple. When taking the drug, the action is directly on the cell walls of the bacteria. They begin to break down, and as a result of this process, irreversible changes in the cytoplasm of the microorganism. After a while, he dies.

It is noteworthy that active substance the drug is able to penetrate into the most deep tissue and restore them. The moment of lack of addiction to pills is very important, even with prolonged use. Helicobacter bacteria cannot adapt to the components of the drug, so it is effective even with refresher course.

Contraindications

Do not forget that De-Nol is not suitable for all patients, despite its high performance. Some health problems can be an obstacle to taking it. However, their list is limited to only a few items:

Reception of other means containing bismuth. This substance tends to accumulate in the body, so there should be a break of at least three to four months between therapeutic courses.
Childhood. Usually a child under the age of fourteen is not prescribed De-Nol. But there are exceptions to this rule: in particular difficult cases doctor can prescribe this medicine a child of four years old. This can be done as part of complex therapy together with two antibiotics. Moreover, the course of treatment with "De-Nol" (such situations are not specified in the instructions for use) should be minimal.
Pregnancy and lactation. Women who are expecting a baby should avoid taking this drug. Its active substance has Negative influence on the fetus, as a result, the child may be born with serious pathologies. During lactation, "De-Nol" is also contraindicated. Its components very easily penetrate into breast milk and disrupt the functioning of the urinary and nervous systems of the crumbs. Result similar treatment mothers can be very deplorable for the baby.
An allergic reaction to bismuth is uncommon, but it can still happen. Therefore, people prone to allergies should not drink De-Nol. Doctors don't prescribe it individual intolerance any component of the medicinal product.
The drug is categorically contraindicated in kidney diseases different nature and the severity of the flow.

The instructions for the tablets indicate that they should not be taken by people with problems associated with liver disease. In these cases, treatment can aggravate them and be supplemented by a number of side effects.

The drug "De-Nol". What course of treatment is considered optimal

The attending physician prescribes the drug to persons suffering from diseases of the digestive tract. However, they must definitely be over fourteen years old. The scheme of admission is only a doctor, it is categorically contraindicated to do it without permission. The specialist takes into account all the nuances of the course of the disease: its stage, severity, age of the patient, and the like.

On average, no more than four tablets of the drug are prescribed per day. Moreover, they should be taken at regular intervals. Depending on the treatment regimen, the doctor may break daily dosage for two or four doses.

The standard course of treatment involves a regimen in which the patient drinks one tablet four times a day. The first three doses take place before breakfast, lunch and dinner, and the last - at night. It is important to take the tablets thirty minutes before meals for absolutely empty stomach. IN this concept includes not only the lack of food in it, but also the liquid.

An alternative course of treatment is prescribed for other diseases. In this case, it is shown to take "De-Nol" two tablets twice a day - before breakfast and dinner. It is important to observe an interval of twelve hours between doses of the medicine.

The drug is required to drink only clean water. Juices, teas and other drinks, reacting with the components of the drug, disrupt the absorption of the drug and its mechanism of action.

It should be borne in mind that the tablets should not be chewed, broken or taken in parts.

The minimum course of therapy is one month, but often doctors advise that with obvious improvements in the condition, accompanied by the neutralization of unpleasant symptoms, stop treatment.

The longest course of "De-Nol" cannot be more than two months of continuous use. If during this period of time the stabilization of the condition has not occurred, then the next time you can start drinking the medicine only after a sixty-day interval

It should be borne in mind that the patient should not take other drugs containing bismuth in their composition. This substance has the effect of accumulation in the central nervous system which negatively affects its performance.

Features of treatment

"De-Nol" is a fairly powerful drug, so some simple rules must be followed when taking it.

Patients should know that the drug is most effective when no food and liquid enters the stomach thirty minutes before the tablet enters the body and thirty minutes after that. The fact is that for the splitting of tablets it is required a large number of gastric juice.

At vegetative dystonia it is necessary to pass the most minimal course of taking "De-Nol". If this recommendation is not followed, the patient's condition will worsen due to regular headaches and dizziness.

Keep in mind that bismuth, which is active ingredient drug, gives such an effect as coloring feces in black light. Despite the fact that this reaction is natural, it must be reported to the attending physician.

If you notice a general deterioration in your condition in the first week of treatment, then perhaps these are side effects of the drug, which means that the course of treatment needs to be stopped.

A few words about side effects

If we analyze all possible negative reactions body to take pills, then most often they occur from the gastrointestinal tract. The main symptoms are nausea, vomiting, violation of daily stools (constipation, diarrhea, increased bowel movements, and so on). Flatulence is also possible, accompanying the patient throughout the day. In some cases, there is a decrease in appetite and a change in taste preferences. Sometimes in the course of treatment there is a persistent taste of metal in oral cavity. The color of the tongue in many patients changes to dark brown after the first days of taking the tablets. All of these reactions are considered symptoms of the body's adaptation to bismuth. They usually go away on their own in one to two weeks.

Allergy is a good reason to stop treatment. This effect manifested by skin itching, rashes on the skin and swelling of the tissues. Such symptoms should be reported to the doctor. After examining the patient, he must decide whether to cancel or change the treatment regimen.

A long course of treatment is possible only under medical supervision. It is prescribed in very rare cases, since the risk of side effects increases several times. In addition, many of them are hazardous to health. Such reactions include nephropathy, encephalopathy, gingivitis, and so on. Often long-term use"De-Nola" is the cause of the development of colitis and arthralgia in patients.

Overdose. How to define it

Having started taking De-Nol, it is important to understand that an overdose of it is extremely dangerous. It causes irreversible changes in the body. Among them, acute renal failure can be distinguished, which in parallel leads to high slagging and increased pressure.

The most dangerous violations of the functions of the brain. Initially, the patient feels only weakness, then insomnia is added to it. If the drug is not stopped, the treatment can be fatal.

Disorders of the gastrointestinal tract, which turned into chronic form, are also one of the results of an overdose of "De-Nol".

It should be borne in mind that an overdose of the drug occurs at such rates as one hundred milligrams of bismuth per liter of blood. This can only be determined in the laboratory.

Patients need to know that there is no antidote for bismuth. Therefore, as emergency assistance in case of overdose, doctors use gastric lavage and adsorbents. In severe cases, urgent hemodialysis is required.

Among the wide range of drugs for gastritis, the most popular is De-nol, which can be easily purchased at a pharmacy without a doctor's prescription. How to take "De-nol" for gastritis, what are the exact indications for its use, whether there are side effects - all this can only be said by the doctor who prescribes the treatment.

"De-nol" is used in the diagnosis of chronic gastritis or gastric ulcer in the acute stage, with irritable bowel syndrome, prolonged diarrhea, dyspeptic disorders various origins for the prevention of gastrointestinal diseases.

The appointment of "De-nol" is made exclusively by a doctor, since the drug can not be used for all types of gastritis, for example, the medicine is not prescribed for acute gastritis.

The drug "De-nol" is available in the form of coated tablets. The active ingredient of "De-nol" is bismuth tripotassium dicitrate. De-nol has a strong enveloping, anti-inflammatory, astringent, antiseptic effect.

The high efficiency of the drug lies in its ability to accelerate the recovery process. When using De-nol, the mucosa is quickly restored, and the damaged areas acquire an almost original appearance.

What does the drug affect? When taking the drug, many processes occur:

compaction of the upper layer of erosion-damaged areas;
activation of the regeneration process;
protection of the walls of the digestive tract from the negative influence of an aggressive environment (acid, bile, enzymes);
lowering the acidity of gastric juice and regulating the production of of hydrochloric acid;
reduction in pain and inflammatory response in the area of damage;
elimination of dyspeptic symptoms: heartburn, nausea and belching;
reducing the number of relapses and exacerbations.

What is the mechanism of action? The tablet, when it enters the stomach, begins to act - it reacts with gastric juice, - the process of precipitation of insoluble bismuth salts, which interact with proteins and form on surface layer mucous organ foamy compounds.

A whitish protective film is formed on the damaged areas of the mucosa, which remains for several hours. This process prevents the negative impact of aggressive biological substances - hydrochloric acid, bile, enzymes, on the intestinal and stomach mucosa with increased acidity.

The drug stimulates the production of prostaglandids, which contributes to the growth of the synthesis of mucin (mucus) and other compounds that improve the properties of gastric secretions. In places of erosion, stimulation occurs recovery processes. "De-nol" is resistant to the influence of hydrochloric acid, which means that it reliably protects the body and does not require additional actions.

In addition, the drug has a very important property: antibacterial, which is very important provided that the causative agent of the disease is the bacterium Helicobacter pylori.

In what cases are they taking "De-nol"

This medicine is applicable for the following diseases and pathologies:

exacerbation of chronic hyperacid, erosive and atrophic gastritis;
hypertrophic gastritis, duodenitis and gastroduodenitis;
stomach and duodenal ulcer;
inflammation caused by bacteria;
gastritis, accompanied by reflux esophagitis;
dyspepsia (in the form of a syndrome);
irritation of the colon (in the form of a syndrome);
Allison's syndrome.

Also, "De-nol" is used for prophylaxis to prevent recurrence of gastritis and ulcers. In addition, there is a list of other diseases in which De-nol is allowed to be used.

Instructions for use for gastritis stipulate at what age and how to take the drug. The use of "De-nol" is allowed for children from 14 years of age. In addition, in special cases, this drug is prescribed to young children.

It is forbidden to give the drug to a child without a doctor's prescription, since bismuth is classified as heavy metals and he renders toxic effect when used incorrectly.

"De-nol" from gastritis is taken, as a rule, as part of complex therapy. Together with him, when prescribing therapy, inhibitors are prescribed. proton pump, antacids, or motility-improving agents.

With concomitant diarrhea are prescribed antidiarrheals, and for constipation - drugs that have a laxative effect.

The presence of Helicobacter pylori implies the addition of De-nol to one or more antibiotics that affect this microorganism.

For the most effective effect of the drug, it is necessary to adhere to the following rules and methods of administration:

do not chew or crush tablets;
it is allowed to drink tablets only with settled clean or boiled water;
while taking the drug or immediately after it is not recommended to consume milk, milk and dairy products- this reduces the effectiveness of treatment with "De-nol";
after taking the remedy, you should not eat, drink fruit juices, compote, tea, coffee, alcoholic beverages;
"De-nol" is consumed half an hour before meals, after taking the drug for 30-40 minutes, you should not use other drugs;
after the end of the course of therapy, for several months you should not use other products containing bismuth as an active substance, in order to avoid its accumulation in the tissues of the body;
during treatment with De-nol, the daily doses of the drug prescribed by the treatment regimen should be observed so as not to provoke the occurrence of side effects.

The duration of the course of treatment is set by the doctor individually, usually its duration is from one to two months.

The therapeutic dosage of the drug depends on accurate diagnosis, age of the patient, body weight (in children).

Before starting the medication, the doctor recommends changing the diet and daily routine: the patient should sleep 8 hours a day and eat at the same time strictly in accordance with the "Table No. 2" diet 4-5 times a day. At the same time, junk food, too hot or too cold dishes are prohibited.

Usually use the following dosage:

from 4 years old. The dosage is prescribed depending on the weight of the patient (8 mg / kg) and is taken in 2 doses, at a time the child drinks 4 mg / kg.
from 8 years: one tablet is drunk in the morning and in the evening.
over 12 years old. Given the stage of the disease and body weight, 3-4 tablets are prescribed. When prescribing 3 tablets, it is better to take them in the following way - in the morning they drink 2 and 1 - at night, when prescribing 4 tablets - evenly distribute the dose and drink 2 tablets at a time.
adults - 1-2 tablets at each meal (half an hour before eating a meal).

Contraindications, overdose, side effects

It is necessary to take De-nol correctly in order to avoid side effects. The use of "De-nol" according to the instructions, compliance with the dosage and rules of administration help to avoid adverse reactions.

The following reactions can be observed as side effects:

skin itching, urticaria;
inflammation and swelling of the gums, blackening of the tongue;
failure of the kidneys;
nausea, sometimes with vomiting, constipation, alternating diarrhea;
bad taste and smell from the mouth after using the medicine;
acquisition of black feces;
disorder of attention and memory (in rare cases);
encephalopathy is possible, which is caused by the accumulation of bismuth in the body (with long-term use of the drug).

Gastrointestinal manifestations may occur frequently but are usually transient and do not require additional treatment as they pass by themselves.

If symptoms of allergic reactions or encephalopathy appear, stop taking the drug and consult a doctor.

Pregnancy and breastfeeding are considered as contraindications. If the situation requires the obligatory intake of the drug by the nursing mother, breastfeeding has to be stopped.

Other contraindications include: severe violations kidney function, intolerance or hypersensitivity to the components of the drug, recent use of drugs with the same active substance or a similar effect.

When antacids are present in the treatment regimen, in addition to De-nol, to get rid of heartburn, De-nol is taken separately from them, since similar drugs reduce its effect. For the same reason, it is forbidden to drink milk simultaneously with the use of the drug.

Kidney damage is possible in the case of a very large dose (exceeding the permitted 10 or more times). In case of bismuth poisoning, gastric lavage is performed, treatment with enterosorbents is prescribed (Polysorb, Polyphepan, Enterosgel, white coal, activated carbon, "Filtrum-STI") and laxatives (magnesium sulfate salt), in especially severe cases, hemodialysis is done.

Antispasmodics may be prescribed for pain relief. With a large amount of bismuth in the blood against the background of kidney pathology, complexing acids can be used. They enter with bismuth into chemical reaction and precipitate it in the form of salts.

The combination of "De-nol" with other drugs

In the presence of Helicobacter pylori bacteria in the body, in combination with De-nol, the following are prescribed: Amoxicillin (Flemoxin, Augmentin, Amoxiclav, Amosin), Metronidazole (Trichopol), Clarithromycin "("Klacid"). In this case, there is a mutual increase antimicrobial activity. Bismuth contained in the preparation interferes with the absorption of tetracycline and reduces its antibacterial effect.

The use of "De-nol" in conjunction with proton pump inhibitors ("Omeprazole", "Omez", "Nolpaza", "Nexium" and others) increases the mutual gastroprotective effect.

Medicines containing bismuth or its combinations increase the risk of overdose (Vikalin, Vikair).

The use of antacids ("Gastal", "Phosphalugel", "Maalox", "Almagel" and others) is possible half an hour before or half an hour after the use of "De-nol".

In the presence of pain in the stomach, you can take antispasmodics - "Dicetel", "No-shpa", "Duspatalin", "Buscopan".

Although most drugs go well with De-nol, it is better to coordinate them joint application with a doctor.

"De-nol" and alcohol consumption

When using De-nol, you should completely abandon the use of alcohol-containing drinks, as it increases the toxic effect of the drug. It should be noted that alcohol is various doses can be present not only in alcoholic beverages, but also in a number of drugs plant origin (alcohol tinctures, extracts, etc.).

The combination of drinking alcohol and taking the drug can lead to complications in the liver.

Drug analogues

In some patients, "De-nol" causes individual intolerance, so the drug needs to be replaced with a similar one. Analogues of "De-nol" can be divided into two groups:

preparations with an identical substance - Ulcavis, Novobismol, Escape;
drugs with similar medicinal effect- gastroprotectors - "Venter", "Rebagit".

Question answer

The doctor prescribed the drug "Ranitidine", but together with the "De-nol", which I use, it is not recommended to drink it, since unwanted reactions are possible. What do i do?
The appointment of any medications should go through the attending physician, so be sure to coordinate the simultaneous use of these two drugs.

biconvex, round shape film-coated tablets, imprinted with “gbr 152” on one side and a graphic image in the form of a square with rounded corners and broken sides on the other. The color of the tablets is white with a creamy tint, the smell is light ammonia (may be absent).

Tablets are packaged in blisters of 8 pieces. One carton box contains 56 or 112 tablets.

pharmachologic effect

Bismuth drug. Renders antibacterial , antiulcer And gastroprotective action.

In accordance with the information provided in Wikipedia, bismuth subcitrate in the Pharmacological Index is included in the group “ Antacids and adsorbents ”.

Pharmacodynamics and pharmacokinetics

Bismuthate tripotassium dicitrate is characterized by a multifaceted effect, due to which the drug De-Nol has an impact on all links of the origin and development peptic ulcer .

The astringent effect is due to the ability bismuth subcitrate precipitate proteins by forming chelate complexes with them. As a result, on the surface of the affected peptic ulcer plots mucous membrane of the stomach and duodenum a protective film is formed, which eliminates the possibility of the harmful effects of the acidic environment of the stomach on the affected mucosa. This, in turn, contributes to faster scarring of ulcers.

De-Nol manifests bactericidal properties in a relationship Gram (-) bacteria Helicobacter pylori . This effect is based on the ability of the active substance of the drug to suppress enzymatic activity in a microbial cell, disrupt the microstructure and permeability of its membranes, as well as the course of vital intracellular processes, reduce the mobility and virulence of microorganisms, as well as their ability to adhere. All of the above leads to the death of microorganisms.

An important feature of the drug and its difference from other drugs used for treatment helicobacter pylori , it is believed that to date not a single strain has been identified that would be resistant to the action of bismuth subcitrate.

The substance dissolves very well, due to which the drug penetrates deep into the mucus layer and inactivates the microorganisms under the mucosa.

Thus, the use of De-Nol tablets can reduce the likelihood of relapse. peptic ulcer .

Gastrocytoprotective effect The drug is based on stimulation of the body's production prostaglandin E2 ; improvement of microcirculation in the mucous membrane of the antrum of the stomach and duodenum 12; a decrease in the amount of hydrochloric acid; inactivation of pepsin due to the fact that this digestive enzyme forms complex compounds with bismuth subcitrate.

Bismuth subcitrate after oral administration is practically not absorbed into digestive tract. A small amount of the substance may enter systemic circulation, and its plasma concentration increases with long-term use. Bismuth subcitrate is eliminated with intestinal contents.

Indications for use De-Nol

Indications for the use of De-Nol are erosive and ulcerative lesions of the gastric and duodenal mucosa .

In particular, the drug is prescribed for gastropathy that are the result of taking NSAIDs or alcohol; at gastroduodenitis and with (including if the diseases occur in or are associated with Helicobacter pylori); with exacerbated (including if the disease is associated with Helicobacter pylori); with IBS ( irritable bowel syndrome ), as well as with functional , which is not related to organic lesions GIT.

In some cases, it is considered appropriate to use De-Nol and when pancreatitis (especially with biliary-dependent). The drug is prescribed in complex therapy to eliminate gastroduodenostasis (hypomotor dyskinesia of the intestine), which is often observed in the chronic form of the disease.

Contraindications

The drug has contraindications. It is forbidden to prescribe De-Nol:

sick with decompensated renal failure ;
pregnant women;
women who are breastfeeding;
children under 4 years of age;
at hypersensitivity to bismuth subcitrate or auxiliary components included in the tablets.

Side effects

Side effects of De-Nol on the part of the digestive system are manifested by nausea, vomiting, constipation or frequent stools. These phenomena do not pose a danger to the health of the patient and are transient.

In some patients, side effects of treatment may occur in the form of hypersensitivity reactions (for example, itching or skin rashes).

Prolonged use of the drug in high doses can cause development due to the accumulation of bismuth in the central nervous system.

Tablets De-Nol: instructions for use

The manufacturer in the instructions for the use of De-Nol indicates that patients older than 12 years of age should take 4 tablets per day.

There are two alternative ways Applications of De-Nol:

one tablet four times a day;
two tablets twice a day.

Tablets are taken half an hour before meals. They need to be washed down with a small amount of water.

How to take De-Nol for children?

In accordance with the instructions for the use of De-Nol, for children older than 4 years of age, the optimal dose of the drug is calculated using the formula 8 mg / day. per 1 kg of body weight. Thus, depending on the weight of the child daily dose can be from 1 to 2 tablets. At the same time, it should be as close as possible to the calculated one (8 mg / kg / day). You can take the medicine once, or you can divide it into two doses.

The duration of the course is four to eight weeks. After completion of treatment, the use of bismuth-containing preparations should be avoided for the next eight weeks.

Recipe in Latin for tablets:
Rep.: Tab. "De-Nol" N.112
D.S. 2 tablets 2 r / day

Why drink and how to drink D-Nol in diseases associated with H. pylori?

De-Nol is characterized by the ability to accumulate in cells Helicobacter bacteria pylori, leading to their destruction cytoplasmic membranes and death of microorganisms.

This, as well as the property of bismuth subcitrate, dissolves well in gastric or duodenal mucus and prevents H. pylori adhesion to epithelial tissue Gastrointestinal tract, allows you to use De-Nol in a variety of schemes for the destruction of these microorganisms.

Frequent use antibacterial drugs And wide use anti-Helicobacter therapy has caused doctors to note a significant increase in the number of patients with antibiotic-resistant strains of H. pylori. Therefore, to solve the problem of eradication, treatment regimens are involved, which include reserve funds.

The patient can often be prescribed De-Nol and, or.

240 mg of bismuth subcitrate (De-Nol) twice a day for 30 days + 400 mg metronidazole and 500 mg three times a day for a weekly course (eradication - 81%);
120 mg bismuth subcitrate, 500 mg and 400 mg metronidazole four times a day for a weekly course (eradication - 89%);
240 mg of bismuth subcitrate, 400 mg metronidazole and 250 mg clarithromycin twice a day for a 10-day course (eradication - 95%);
240 mg bismuth subcitrate twice daily, 500 mg Flemoxin Solutab , 100 mg furazolidone four times a day two-week course(eradication - 86%);
240 mg of bismuth subcitrate, 200 mg furazolidone and 750 mg tetracycline twice a day for a weekly course (eradication - 85%);
240 mg of bismuth subcitrate, 100 mg furazolidone and 250 mg clarithromycin twice a day for a weekly course (eradication - 92%);
240 mg of bismuth subcitrate, 1000 mg Flemoxin Solutab and 250 mg clarithromycin twice a day for a weekly course (eradication - 93%);
120 mg of bismuth subcitrate, 250 mg clarithromycin and 250 mg tetracycline four times a day for a 10-day course (eradication - 72%);
120 mg of bismuth subcitrate and 500 mg Flemoxin Solutab four times a day and twice a day 20 mg omeprazole two-week course (eradication - 77%);
120 mg bismuth subcitrate four times a day, 500 clarithromycin and 40 mg omeprazole twice a day for a weekly course (eradication - 83%).

The challenge of eradicating strains of H. pylori resistant to metronidazole , at the lowest cost allows you to decide the use of the drug De-Nol in combination with furazolidone .

The most effective from a clinical and economic point of view is considered to be the scheme “bismuth subcitrate + amoxicillin + furazolidone ”.

The answer to the question “With what to take De-Nol?” can only be given by the attending physician, depending on the characteristics of the course of the disease.

Overdose

A symptom of an overdose of De-Nol is a violation functional activity kidneys. The phenomenon is reversible, kidney function is fully restored after discontinuation of the drug.

Treatment of an overdose involves a gastric lavage procedure, the appointment of saline laxatives and enterosorbents. Further therapy is symptomatic.

If kidney dysfunction is accompanied sharp rise plasma concentration of bismuth, the patient is administered chelating agents (for example, or D-penicillamine ). With severe violations of renal function may be required.

Interaction

The effectiveness of De-Nol may vary with simultaneous reception with other drugs, as well as food and liquids (in particular, with antacids , fruits, milk, fruit juices), from which it is considered optimal to take tablets half an hour before and half an hour after eating or taking any other medications.

The use of the drug in combination with tetracyclines reduces the absorption of the latter.

Terms of sale

Non-prescription drug.

Storage conditions

Keep away from children, exposure to sunlight and moisture. Optimal temperature regime for storage - 15-25 ° C.

Best before date

48 months.

special instructions

The annotation indicates that the maximum duration of the course of De-Nol is 8 weeks.

During treatment, do not exceed the dose of the drug prescribed by the doctor and take other bismuth-containing drugs.

After completion of treatment with De-Nol, the plasma concentration of bismuth subcitrate ranges from 3 to 58 μg / l. Symptoms of intoxication appear only in cases where the concentration of the substance exceeds 100 μg / l.

During the period of use of the drug, black stools are possible. The reason for this phenomenon is the formation of Bi2S3 (bismuth sulfide). Sometimes the tongue may darken slightly.

There are no data on the effect of De-Nol on the ability to drive machinery and a car.

Sometimes you can find the names De-Nol and Di-Nol, however, it is still correct to write De-Nol.

De-Nol - an antibiotic or not?

Despite their antimicrobial properties De-Nol does not belong to the group of antibiotics and, therefore, is devoid of their inherent side effects.

For specialists, the tool is interesting primarily because H. pylori does not have even the slightest possibility of forming resistance to it. The inclusion of De-Nol in the combined scheme antihelicobacter therapy allows you to significantly increase its effectiveness and in most cases, completely get rid of the infection.

In addition, the drug enhances the protection of the gastric mucosa from the damaging effects of the digestive juice and contribute to its recovery. These effects develop due to the fact that De-Nol turns into a colloidal solution in the stomach.

The solution particles form a protective film on the damaged and inflamed areas of the mucous membrane, which accelerates the healing of tissues and prevents the formation of a rough scar. The latter is very important to prevent exacerbations of the disease.

The price of De-Nol analogues is from 20 Russian rubles.

Alcohol compatibility

During treatment with the drug, alcohol should be avoided.

Taking De-Nol during pregnancy

De-Nol is contraindicated during pregnancy. It should also be avoided in breastfeeding women.

Among the huge number of drugs that are presented on the Russian market, it is difficult to find drugs that do not cause side effects. Despite the achievements of modern pharmaceuticals, almost all drugs, even if taken correctly and the dosage is observed, can cause some harm to the patient's body. However, it is impossible to do without medications at all, because in a number of diseases it is required to carry out therapy as quickly as possible.

The list of such problems is quite wide, and diseases of the stomach and duodenum occupy not the last place in it. When making such diagnoses, the doctor usually prescribes a course of treatment with De-Nol. This drug is considered one of the most effective and safe. Of course, this statement is true only if all medical recommendations issued simultaneously with the appointment are observed. However, most patients still have many questions regarding this drug. How many days does the course of treatment with De-Nol last for a stomach ulcer? How to take pills correctly? How often to repeat the course "De-Nol"? Is it normal for side effects to occur during treatment? What is the optimal course of "De-Nol" for gastritis?

Judging by the above questions, most often patients are trying to find out details about the duration of treatment. It is this topic that we will cover in the article. Readers will draw from it all the information they are interested in about the De-Nol treatment course. We will also briefly describe the drug itself and note all the features of its administration.

General characteristics of the drug

So, first of all, it is worth understanding that this drug is one of the most powerful. In addition, it allows you to comprehensively approach the problem, and this already makes it possible to prescribe a simplified scheme and course of treatment. Many patients confuse "De-Nol" and "Omez" with each other, considering them to be equivalent drugs and replacing them at will. However, this cannot be done, since the tool we are describing is unique in many respects.

I would like to mention that even with a long course of taking De-Nol, Helicobacter pylori cannot develop resistance to the drug. The drug is equally effective in primary and secondary treatment. Such characteristics are rarely combined in one drug.

Release form of the drug

Before starting a course of treatment with De-Nol for gastritis or peptic ulcer, you need to protect yourself from fakes. To do this, you need to study how the tablets should look.

The pills are very well protected from counterfeiting due to embossing. It is applied on both sides and consists of an inscription and a graphic drawing. Some patients who underwent a course of treatment with De-Nol complained of an unpleasant odor coming from the tablets. Pharmacists note that this is the norm. Original tablets may not emit a very pronounced smell of ammonia.

The manufacturer packs the drug in cardboard boxes. Each contains several blisters. They contain eight tablets. On average, from seven to fourteen blisters are invested in a pack. The maximum number of tablets in a package is one hundred and twelve.

The composition of the drug and dosage

"De-Nol" consists of active and additional substances. Bismuth oxide belongs to the first category. It is this substance that provides a wide therapeutic effect that the drug has. It is in each tablet 120 milligrams.

corn starch;
povidone;
magnesium stearate;
potassium polyacrylate.

In addition, it is necessary to mention the components that make up the film shell of the tablets:

macrogol;
hypromellose.

All excipients are in the drug in small quantities.

Indications for taking tablets

In almost one hundred percent of cases, the doctor prescribes a course of treatment with De-Nol for stomach ulcers and gastritis. However, these are not the only indications for taking this drug. The list of health problems that pills effectively cope with is quite voluminous:

peptic ulcer of the duodenum in different stages of the course;
gastroduodenitis;
irritable bowel syndrome (including with diarrhea as one of the symptoms);
dyspepsia;
peptic ulcer of the stomach;
peptic ulcer of the duodenum;
damage to the gastric mucosa.

Most often, the last of these problems occurs with long-term use of non-steroidal anti-inflammatory drugs.

The action of the drug

The spectrum of action of the tablets is quite wide, therefore, with peptic ulcer and gastritis, the course of treatment with De-Nol is so effective. Even after the initial intake, the drug forms a protective film that envelops the inner walls of the stomach. At the same time, it very effectively neutralizes Helicobacter pylori.

In parallel, the drug helps to normalize the acid-base balance, improve blood circulation in the stomach, and accelerate metabolic processes. It was also noticed that during the treatment process the rate of regeneration of damaged tissues increases.

The mechanism of action of tablets on the causative agent of peptic ulcer

From our article, readers have already learned that De-Nol treats. The course of treatment with this drug successfully neutralizes Helicobacter pylori.

The mechanism of action of the drug on this harmful microorganism is quite simple. When taking the drug, the action is directly on the cell walls of the bacteria. They begin to break down, and as a result of this process, irreversible changes occur in the cytoplasm of the microorganism. After a while, he dies.

It is noteworthy that the active substance of the drug is able to penetrate into the deepest tissues and restore them. The moment of lack of addiction to pills is very important, even with prolonged use. Helicobacter bacteria cannot adapt to the components of the drug, so it is effective even with a repeated course.

Contraindications

Do not forget that De-Nol is not suitable for all patients, despite its high performance. Some health problems can be an obstacle to taking it. However, their list is limited to only a few items:

Reception of other means containing bismuth. This substance tends to accumulate in the body, so there should be a break of at least three to four months between therapeutic courses.
Childhood. Usually, a child under the age of fourteen is not prescribed De-Nol. But there are exceptions to this rule: in especially difficult cases, the doctor can prescribe this medicine to a baby from four years old. This can be done as part of complex therapy together with two antibiotics. Moreover, the course of treatment with De-Nol (such situations are not specified in the instructions for use) should be minimal.
Pregnancy and lactation. Women who are expecting a baby should avoid taking this drug. Its active substance has a negative effect on the fetus, as a result, the child may be born with serious pathologies. During lactation, "De-Nol" is also contraindicated. Its components very easily penetrate into breast milk and disrupt the functioning of the urinary and nervous systems of the crumbs. The result of such treatment of the mother can be very deplorable for the baby.
An allergic reaction to bismuth is uncommon, but it can still happen. Therefore, people prone to allergies should not drink De-Nol. Doctors do not prescribe it and with individual intolerance to any components of the drug.
The drug is categorically contraindicated in kidney diseases of a different nature and severity of the course.

The drug "De-Nol". What course of treatment is considered optimal

On average, no more than four tablets of the drug are prescribed per day. Moreover, they should be taken at regular intervals. Depending on the treatment regimen, the doctor may divide the daily dosage into two or four doses.

The standard course of treatment involves a regimen in which the patient drinks one tablet four times a day. The first three doses take place before breakfast, lunch and dinner, and the last - at night. It is important to take the tablets thirty minutes before meals on a completely empty stomach. This concept includes not only the absence of food in it, but also liquid.

The drug is required to drink only clean water. Juices, teas and other drinks, reacting with the components of the drug, disrupt the absorption of the drug and its mechanism of action.

It should be borne in mind that the tablets should not be chewed, broken or taken in parts.

The minimum course of therapy is one month, but often doctors advise that with obvious improvements in the condition, accompanied by the neutralization of unpleasant symptoms, stop treatment.

It should be borne in mind that the patient should not take other drugs containing bismuth in their composition. This substance gives the effect of accumulation in the central nervous system, which negatively affects its work.

Features of treatment

"De-Nol" is a fairly powerful drug, so some simple rules must be followed when taking it.

With vegetovascular dystonia, it is necessary to undergo the most minimal course of taking De-Nol. If this recommendation is not followed, the patient's condition will worsen due to regular headaches and dizziness.

Keep in mind that bismuth, which is the active ingredient of the drug, has the effect of turning feces black. Despite the fact that this reaction is natural, it must be reported to the attending physician.

If you notice a general deterioration in your condition in the first week of treatment, then perhaps these are side effects of the drug, which means that the course of treatment needs to be stopped.

A few words about side effects

If we analyze all the possible negative reactions of the body to taking pills, then most often they occur from the gastrointestinal tract. The main symptoms are nausea, vomiting, violation of daily stools (constipation, diarrhea, increased bowel movements, and so on). Flatulence is also possible, accompanying the patient throughout the day. In some cases, there is a decrease in appetite and a change in taste preferences. Sometimes in the course of treatment there is a persistent taste of metal in the oral cavity. The color of the tongue in many patients changes to dark brown after the first days of taking the tablets. All of these reactions are considered symptoms of the body's adaptation to bismuth. They usually go away on their own in one to two weeks.

Allergy is a good reason to stop treatment. This effect is manifested by skin itching, rashes on the skin and swelling of the tissues. Such symptoms should be reported to the doctor. After examining the patient, he must decide whether to cancel or change the treatment regimen.

A long course of treatment is possible only under medical supervision. It is prescribed in very rare cases, since the risk of side effects increases several times. In addition, many of them are hazardous to health. Such reactions include nephropathy, encephalopathy, gingivitis, and so on. Often, prolonged use of "De-Nol" is the cause of the development of colitis and arthralgia in patients.

Overdose. How to define it

The most dangerous violations of the functions of the brain. Initially, the patient feels only weakness, then insomnia is added to it. If the drug is not stopped, the treatment can be fatal.

Disorders of the gastrointestinal tract, which have become chronic, are also one of the results of an overdose of De-Nol.

It should be borne in mind that an overdose of the drug occurs at such rates as one hundred milligrams of bismuth per liter of blood. This can only be determined in the laboratory.

Patients need to know that there is no antidote for bismuth. Therefore, as an emergency aid for overdose, doctors use gastric lavage and adsorbents. In severe cases, urgent hemodialysis is required.

How to drink De nol, how effective is it? This question is of interest to those who suffer from stomach diseases.

There are many factors that negatively affect human health. Due to malnutrition, frequent stress, lack of sleep, a person begins to feel pain in the stomach. In this case, De Nol tablets will help to cope with the discomfort.

Composition and pharmacokinetics

De Nol is a new generation antibiotic that destroys pathogenic microbes. Produced in the form of oval tablets, coated with a fast-dissolving shell. The main producer is the Netherlands. The protective properties of this drug, which contains bismuth tripotassium dicitrate, have proven themselves well. The mechanism of action of the drug is as follows: the tablet enters the stomach and the sore spots are covered with a thin film and heal quickly.

De Nol is included in the complex treatment regimen. It is prescribed to those patients who have impaired functions of the gastrointestinal tract, with peptic ulcer of the stomach and duodenum, gastritis, dyspepsia, irritable bowel syndrome. You can drink de-nol for those who want to get rid of heartburn with low stomach acidity, cholecystitis, colitis, and other ailments.

Any ailment requires proper treatment, depending on this, the course of treatment, the dosage of the drug are determined.

Application for diseases of the stomach

With a stomach ulcer, the Helicobacter bacterium makes a person suffer. These harmful microorganisms increase the acidity of gastric juice. While in the body, they may not manifest themselves for quite a long time. Until the immune system fails, which can provoke:

transferred illness;
antibiotic;
avitaminosis;
stressful conditions;
bad habits (alcohol, smoking);
unbalanced diet;
hereditary factors.

Symptoms of stomach ulcer:

constantly experienced pain (may intensify in autumn and spring);
vomiting with a sour taste;
heartburn.

With an ulcer, pain usually appears during or after eating. In a hungry state, the stomach calms down. To get rid of discomfort, drink a glass of milk or eat light porridge. To reduce acidity, they drink baking soda, which relieves pain in case of an ulcer. You can greatly improve your condition if you take De nol, after consulting with your doctor.

The formation of a duodenal ulcer also occurs from exposure to Helicobacter bacteria. The risk group includes:

those in whose family someone suffered from this disease;
drinking a lot of coffee;
heavy smokers;
alcoholics;
those who do not eat properly;
often experiencing nervous strain;
patients with gastritis.

Symptoms of the disease:

stabbing or cutting pain;
nausea, sometimes with vomiting;
bloating or constipation;
loss of appetite.

The doctor will send you for an examination. And if it turns out that the cause of the ulcer is Helicobacter bacteria, then Denol will help solve the problem.

Causes of the disease:

preference for spicy food;
passion for alcoholic beverages;
nervous tension;
lack of diet.

Symptoms of an acute form of gastritis:

strong pain;
nausea after eating;
heartburn;
vomiting with mucus;
excessive salivation;
diarrhea or constipation;
chills and high fever;
cardiopalmus;
increased sweating and weakness.

In this case, you should definitely see a doctor who will determine how to take de-nol for gastritis and prescribe a course of treatment.

Required dosage

Drink De nol should be half an hour before meals. Eating 3 times a day, the patient drinks 3 tablets before meals before eating, drinks 1 tablet at night. Another option is to take 2 tablets before breakfast and before dinner. The tablet should not be chewed, it should be swallowed with non-carbonated water. Milk, coffee, tea are not suitable for this, as there is a risk of a negative effect on the effectiveness of the drug.

The duration of treatment depends on the severity of the disease. The course of treatment usually lasts no more than 2 months, after this period the drug should not be taken.

After taking the drug, it is better to suspend the use of other drugs containing bismuth for 2 months.

An overdose is possible if the drug was taken in large doses or for a long time. In this case, the function of the kidneys is impaired. To get rid of the identified symptoms, it is enough to stop the drug.

First aid for overdose - gastric lavage, activated charcoal and saline laxatives.

In the future, symptomatic therapy will be needed. If the examination shows a high level of bismuth in the blood, the doctor will prescribe a complex treatment. With a pronounced character resort to hemodialysis. Any manifestation of symptoms of an overdose is a signal for drug withdrawal.

If the stomach is treated, then sour dishes will not be useful. Harmful food will nullify the beneficial effect of the medicine. Therefore, before taking Denol, it is wise to discuss with your doctor what drugs and products you can use during treatment. After all, any excellent medicine, if taken incorrectly, will not give a positive result, and can even harm the body.

Contraindications and side effects of the drug

Before you start taking De-nol for gastritis and other ailments, you need to find out who this drug is not suitable for.

You should be wary if there are such factors:

individual intolerance to the drug;
impaired renal function;
During pregnancy and breastfeeding.

Failure to comply with the rules for taking the drug can lead to serious health problems, and in case of pregnancy, there is a threat to the normal functioning of the internal organs of the unborn baby. You should not decide on your own how to take the pills. Only a specialist can determine the dosage, taking into account the individual characteristics of the patient. It will also be necessary to find out if there will be problems with the absorption of the drug by the body.

Side effects can manifest themselves in the form of an allergic reaction and disorders of the digestive system.

Allergy is indicated by a rash on the skin, itching. In this case, you need to see a doctor who will decide to change the dosage downward or suggest another antibiotic. Unpleasant symptoms after taking the medication are not excluded - nausea, vomiting, frequent stools or constipation. These negative effects will soon pass. If this does not happen, then the medicine is not suitable and you should stop taking it. With prolonged uncontrolled use of the drug, the destruction of nerve cells develops, which leads to encephalopathy. The reason is the accumulation of bismuth compounds in the tissues of the nervous system.

Storage rules

Only a dry place is suitable for storing the drug, where they do not fall Sun rays, the temperature in the room should not exceed 25 ° C, otherwise the medicine may soon become unusable.

It should be borne in mind that storage in a refrigerator, in a damp room can affect the loss of the properties of the drug. It is best to keep De nol in a special first aid kit, which will be out of the reach of children.

You also need to pay attention to appearance tablets. There should be no mechanical damage, punctures, otherwise it is better not to use such medicine. A change in color and smell can also indicate non-compliance with storage conditions, so these tablets are also not suitable for oral administration. In general, De nol does not require special conditions storage. It is important to maintain the temperature regime.

Keep in mind that the shelf life of the tablets is determined at 48 months.

De nol is the most effective medicine in the treatment of stomach ulcers and helps to cope with chronic gastritis. Important condition- complex treatment. Be sure to consult a gastroenterologist before drinking the drug and in no case self-medicate.

Pathology of the digestive tract is one of the most common problems among mankind. From gastritis and peptic ulcer mainly middle-aged people suffer. Pathologies are caused various factors aggression. They act from the outside and from the inside, and with a decrease defensive forces the body undergoes an inflammatory process. For the treatment of this condition, there is a special scheme, and you can choose it for each individually. Basically, several drugs are combined. You need to know how to take "Phosphalugel" and "De-nol" together, as they are considered the main ones in the fight against the disease.

These drugs are taken alone or in combination, which increases healing effect. Before understanding their work, it is necessary to understand how they act individually and in a complex manner. How to take Phosphalugel and De-nol together can be found in the annotation attached to the drugs.

Indications for the appointment of the drug "De-nol"

There is a certain number of indications for prescribing a drug for lesions of the digestive tract. These include:

ulcers of the mucous membrane of the stomach and intestines;
gastritis in exacerbation with different acidity;
heartburn;
dyspeptic condition;
dyspepsia not associated with an ulcer;
reflux gastritis;
functional lesions of the digestive tract.

The course of treatment for each patient is individual. It is allowed to combine the means "De-nol" and "Phosphalugel" (drugs and the scheme are set depending on the indications, the degree of damage to the digestive tract).

The use of the drug "De-nol" separately from other means

The drug is classified as an astringent. Bismuth subcitrate is the basis in the treatment of diseases of the digestive tract. "De-nol" creates a protective film against hydrochloric acid and other aggressive factors. It is produced in tablets that are taken orally. With exacerbation of gastritis and ulcers, the remedy shows a high level of effectiveness. "De-nol" is used to treat irritable bowel syndrome. Patients with a functional dyspeptic condition take a drug that shows good result regarding illness.

yersinia;
rotoviruses;
clostridia;
coli;
shigella.

The drug creates a certain barrier not only in the way of bacteria, but also protection against the penetration of toxic substances. They can enter the body from the outside in the form medicines(cytostatic substances and non-steroidal anti-inflammatory drugs), alcoholic beverages.

Rules for taking the drug "De-nol"

People over 12 years old can take the medication no more than 4 times a day, 1 tablet. You only need to drink it with water. The drug is taken 30 minutes before meals and at bedtime. In exceptional cases, which are associated with the patient's condition, the gastroenterologist prescribes 2 tablets of the drug "De-nol" at the same time. Children are prescribed an individual dosage.

Indications for the appointment of the drug "Phosphalugel"

The spectrum of indications for the use of the drug is very similar to when it is necessary to use De-nol. Therefore, they can be combined in a scheme for such pathologies as:

peptic ulcer;
diaphragmatic hernia;
dyspepsia of various origins;
reflux esophagitis;
diarrhea unrelated to peptic ulcer digestive tract.

Before starting treatment, you need to read the annotation in order to know how to take De-nol with Phosphalugel. Dosage and frequency of administration is set depending on the indications and severity of the patient's condition.

The use of the drug "Phosphalugel" separately from other means

The drug is available in the form of a gel. Main active ingredients in the fight against inflammatory process digestive tract are:

agar-agar;
aluminum phosphate;
sorbitol;
pectin.

Due to the adsorbing, enveloping ability, the drug protects the mucous membrane from the aggressive influence of hydrochloric acid. Chronic gastritis"De-nol", "Phosphalugel" are treated according to a certain scheme, depending on the age and severity of the condition.

The drug has the ability to reduce the action of pepsin and bind bile acids. "Phosphalugel" is highly effective in irritable bowel syndrome and functional dyspepsia. The adsorbent properties of the drug allow you to get rid of harmful microorganisms that cause fermentation processes in the digestive tract. Toxic Substances entering the body are quickly neutralized by the main components, which protects the sensitive mucous membrane from the effects of aggressive factors.

The drug should be taken in pure form or diluted with water at room temperature. Adults and children are shown taking several sachets of the drug during the day, depending on the severity of the condition.

At ulcerative lesion the mucous membrane of the stomach and intestines, a sachet of medicine must be taken one hour after a meal. At functional disorders Gastrointestinal "Phosphalugel" is taken in the morning, afternoon and evening.

Rules for taking medication

With diseases of the digestive system and the presence of indications, the gastroenterologist will tell you how to take Phosphalugel and De-nol together. They should be drunk separately from other drugs included in the treatment regimen. Means "De-nol" and "Phosphalugel" have good compatibility, and therefore they are allowed to be taken with a difference of several hours. The first is usually prescribed half an hour before meals, and the second should be drunk after meals, but after 1.5-2 hours. They interact at such a level that they do not reduce or increase efficiency in the presence of each other.

Side effects

Medicines have wide range indications in the pathology of the gastrointestinal tract in the acute phase. Like any drug, they can cause side effects. These include:

an allergic reaction with intolerance to certain components;
"Phosphalugel" is able to provoke constipation, and "De-nol" - diarrhea;
nausea or vomiting.

In connection with the listed conditions, it is impossible to accept funds on your own. Beforehand, it is necessary to consult a specialist and collect the necessary information that will prevent the development of these conditions. To avoid the development of complications, you should first read the instructions that indicate how to take Phosphalugel and Omeprazole for gastritis, ulcers and other pathologies.

Contraindications to the use of drugs

There are certain conditions when it is temporarily or not at all recommended to be treated with De-nol and Phosphalugel medications, both in monotherapy and in combination. These include the following states:

chronic kidney failure flowing in severe severity;
intolerance to certain substances that form the basis of the drug or are among the additional ones;
diabetes.

These conditions are not always an absolute limitation for taking medications. To find out this question, you need to consult with a specialist.