Lopedium indications for use. Lopedium is a potent antidiarrheal drug

The drug "Lopedium" is a symptomatic antidiarrheal agent. Many people ask about the drug "Lopedium", what else is it used for? The medicine is prescribed for radiation, drug-induced or allergic diarrhea.

Pharmacological action and release form

The antidiarrheal effect occurs quickly after using the drug "Lopedium". This reduces the motility and tone of the smooth muscles of the intestine; in addition, the medicine helps reduce the urge to retain masses of feces and defecation. The action lasts about 6 hours. The product is produced in the form of gelatin capsules of gray color, which contain a homogeneous white powder. Each capsule contains 2 mg of loperamide hydrochloride. Auxiliary components include magnesium stearate, lactose monohydrate, talc, corn starch. In addition, they produce white round tablets with a similar composition.

Medicine "Lopedium": what should you take it for?

The drug is prescribed in the following cases:

• To regulate stool during ileostomy;
• As an adjuvant for diarrhea of ​​infectious origin;
• As a symptomatic treatment of acute and chronic diarrhea of ​​medicinal, emotional, radiation or allergic etymology;
• For diarrhea caused by a change in diet;

.

Contraindications for the drug "Lopedium"

What is no medicine prescribed for? The medication should not be used for:

• Diarrhea due to pseudomembranous acute enterocolitis;
• Ulcerative colitis in the acute stage;
• Intestinal obstruction;
• Diverticulosis;
• For dysentery and other infections of the gastrointestinal system;
• In case of individual intolerance to the components.

Contraindications include children under 6 years of age, lactation and the first trimester of pregnancy. The medicine is used with caution in liver failure.

Instructions for use

Capsules and tablets are taken orally without chewing. For acute and chronic diarrhea, adults are initially prescribed 2 capsules or tablets of Lopedium, then, in the case of loose stools, one tablet after each bowel movement. It is not recommended to take more than the maximum daily dose - 8 tablets. Children over 6 years of age are prescribed 1 pill after each bowel movement, but not more than 6 mg per day. The use of the drug can be discontinued 12 hours after the cessation of symptoms.

In case of an overdose of Lopedium according to the instructions, loss of coordination, stupor, miosis, drowsiness, muscle hypertonicity, respiratory depression, and in some cases, intestinal obstruction may develop. For treatment, Naloxone and symptomatic treatment under medical supervision are used for 48 hours.

Side effects of the drug "Lopedium"

Children experience nausea and skin rashes. In adults, various negative effects are also possible:

• Skin rash;
• Drowsiness or insomnia;
• Constipation;
• Dizziness;
• Nausea;
• Headache;
• Vomit;
• Intestinal colic;
• Gastralgia;
• Dry mouth.

The drug "Lopedium" is discontinued if constipation or bloating occurs.

HEXAL HEXAL/ Salutas Pharma GmbH Hexal AG Salutas Pharma GmbH Salutas Pharma GmbH/ Lek S.A. Salutas Pharma GmbH/Hexal AG

Country of origin

Germany Germany/Poland

Product group

Digestive tract and metabolism

Antidiarrheal symptomatic drug

Release forms

• Capsules - 10 pcs. Tablets - 10 pcs per pack.

Description of the dosage form

• Hard gelatin capsules, with a gray body and a dark green cap; the contents of the capsules are white homogeneous powder. The tablets are white or almost white, round, convex on one side and scored on the other, the surface is beveled towards the score. The tablets are white or almost white, round, convex on one side and scored on the other, the surface is beveled towards the score.

pharmachologic effect

Antidiarrheal symptomatic drug. By binding to opioid receptors in the intestinal wall, loperamide reduces the tone and motility of intestinal smooth muscles. Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter. Helps retain feces and reduce the urge to defecate. The action occurs quickly and lasts for 4-6 hours.

Pharmacokinetics

After oral administration, the absorption of loperamide is about 40%, and undergoes intensive metabolism during the “first pass” through the liver. A small amount of unchanged loperamide enters the systemic circulation. Does not penetrate the BBB. Metabolized in the liver. T1/2 is 9-14 hours. It is excreted through bile with feces in the form of conjugated metabolites, a small part is excreted in the urine.

Special conditions

If there is no effect after 2 days of using Lopedium, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea. If constipation or bloating develops during treatment, the drug should be discontinued. In patients with impaired liver function, careful monitoring for signs of toxic damage to the central nervous system is necessary. During the treatment period, it is necessary to replenish the loss of fluid and electrolytes. Each Lopedium tablet or capsule corresponds to 0.01 XE. Impact on the ability to drive vehicles and operate machinery If drowsiness or dizziness occurs, you should refrain from driving vehicles and operating machinery.

Compound

• loperamide hydrochloride 2 mg Excipients: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate. loperamide hydrochloride 2 mg Excipients: lactose monohydrate, corn starch, talc, magnesium stearate. Composition of the hard gelatin capsule body: gelatin, iron (III) black oxide (E172), titanium dioxide. Composition of the hard gelatin capsule cap: gelatin, iron (III) oxide yellow (E172), blue dye (E131), iron (III) oxide black (E172), titanium dioxide (E171).

Lopedium indications for use

• - symptomatic treatment of acute and chronic diarrhea of ​​allergic, emotional, drug and radiation origin; - diarrhea when changing diet, quality food composition, impaired absorption and metabolism; - as an adjuvant for diarrhea of ​​infectious origin; - regulation of stool in patients with ileostomy.

Lopedium contraindications

• - diverticulosis; - intestinal obstruction; - ulcerative colitis in the acute stage; - diarrhea due to acute pseudomembranous enterocolitis; - as monotherapy for dysentery and other gastrointestinal infections; - I trimester of pregnancy; - lactation period; - children under 6 years of age; - hypersensitivity to the components of the drug. The drug should be used with caution in patients with liver failure.

Lopedium dosage

Lopedium side effects

• From the digestive system: gastralgia, dry mouth, nausea, vomiting, intestinal colic, constipation; very rarely - intestinal obstruction. From the central nervous system: drowsiness or insomnia, dizziness, headache. Allergic reactions: skin rash.

Drug interactions

It is believed that when used concomitantly, cholestyramine may reduce the effectiveness of loperamide. When used simultaneously with co-trimoxazole and ritonavir, the bioavailability of loperamide increases, which is due to inhibition of its metabolism during the “first pass” through the liver. In case of an overdose of loperamide, naloxone is used as an antidote.

Overdose

CNS depression (stupor, incoordination, drowsiness, miosis, muscle hypertonicity, respiratory depression), intestinal obstruction

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

Information provided by the State Register of Medicines.

Synonyms

• Vero-Loperamide, Diarol, Imodium, Lopedium ISO, Loperamide, Loperamide-Ratiopharm, Loperamide-Acri, Loperamide-Rivo, Loperamide-Rivopharm, Loperamide hydrochloride, Loperamide hydrochloride "LH", Neo-enteroseptol, Superilop, Enterobene

Lopedium is an effective antidiarrheal drug that belongs to the group of peripheral opioid receptor agonists. The main active substance is loperamide. The drug inhibits peristalsis, increases sphincter tone and makes the process of passing feces longer. Reduces the number of urges to defecate and the acts themselves. It is used to treat acute and chronic forms of diarrhea (emptying the intestines with liquid feces) of various origins, including infectious and allergic in nature. The medicine is also prescribed to patients with ileostomy to normalize stool. It acts very quickly and retains the effect for up to 6 hours.

1. Pharmacological action

A drug that has an antidiarrheal effect. Reduces the tone and motor activity of the smooth muscles of the intestinal wall, slows down the natural vibrations of the digestive system and increases the tone of the anal sphincter. The use of Lopedium helps to retain feces and reduce the urge to go to the toilet.

2. indications for use

• acute and chronic course of allergic, medicinal, radiation or emotional origin;
• Diarrhea of ​​infectious origin (as an additional drug);
• caused by various nutritional disorders;
• Regulation of bowel movements in patients with ileostomy.

3. Method of application

Recommended dosage of Lopedium for:

• pediatric patients over six years of age: 2 mg of the drug after each occurrence of loose stools;
• adult patients: 4 mg of the drug (initial dosage), then 2 mg of the drug after each case of loose stool.

Features of application:

• After the cessation of diarrhea or in the absence of stool for 12 hours, use should be discontinued;
• If there is no therapeutic effect during use, it is necessary to clarify the origin of diarrhea;
• If constipation or bloating develops, treatment should be discontinued;
• During treatment, you should take increased amounts of fluid.

4. Side effects

• Central nervous system: sleep disturbances, headaches, dizziness;
• Hypersensitivity reactions: skin rashes;
• Digestive system: pain in the stomach, nausea, colicky abdominal pain, intestinal obstruction, dry mouth, vomiting, constipation.

5. Contraindications

6. During pregnancy and lactation

Use of Lopedium in the first trimester of pregnancy strictly contraindicated.

The use of Lopedium during breastfeeding is possible only after stopping it for the entire duration of Lopedium use.

7. Interaction with other drugs

No negative drug interactions have been described with Lopedium.

8. Overdose

• Central nervous system: impaired coordination of movements, constriction of the pupil, respiratory depression, stupor, drowsiness, increased muscle tone;
• Digestive system: intestinal obstruction.

The antidote to Lopedium is Norakson.

9. Release form

Capsules, 2 mg - 10, 20, 30 or 50 pcs.
Tablets, 2 mg - 10, 20, 30 or 50 pcs.

10. Storage conditions

Lopedium should be stored in a dry place.

11. Composition

1 tablet:

• Excipients: lactose monohydrate, calcium hydrogen phosphate dihydrate, corn starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate.

1 capsule:

• loperamide hydrochloride - 2 mg;
• Excipients: lactose monohydrate, corn starch, talc, magnesium stearate.

12. Conditions for dispensing from pharmacies

The drug is available without a prescription.

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* Instructions for medical use of the drug Lopedium are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

Tablets, capsules

10, 20, 30 and 50 pcs.

Composition and active substance

Lopedium includes:

Lopedium Tablets

1 tablet contains:

Excipients: lactose monohydrate calcium hydrogen phosphate dihydrate corn starch sodium starch silicon glycolate colloidal magnesium dioxide stearate.

Lopedium Capsules

1 capsule contains:

Active substance: loperamide hydrochloride 2 mg

Excipients: lactose monohydrate starch corn talc magnesium stearate.

pharmachologic effect

Lopedium is a symptomatic antidiarrheal drug.

By binding to opioid receptors in the intestinal wall, loperamide reduces the tone and motility of intestinal smooth muscles. Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter. Helps retain feces and reduce the urge to defecate.

The action occurs quickly and lasts for 4-6 hours.

Pharmacokinetics

Suction

Loperamide absorption is 40%. The time to reach Cmax is 2.5 hours.

Distribution

Plasma protein binding - 97%. Does not penetrate the BBB.

Metabolism

Almost completely metabolized in the liver by conjugation.

Removal

It is excreted primarily in bile and urine. T1/2 is 9-14 hours.

What does Lopedium help with: indications

• symptomatic treatment of acute and chronic diarrhea of ​​allergic, emotional, drug and radiation origin
• diarrhea with changes in diet, quality food composition, impaired absorption and metabolism
• as an adjuvant for diarrhea of ​​infectious origin
• regulation of stool in patients with ileostomy.

Contraindications

• diverticulosis
• intestinal obstruction
• ulcerative colitis in the acute stage
• diarrhea due to acute pseudomembranous enterocolitis
• as monotherapy for dysentery and other gastrointestinal infections
• I trimester of pregnancy
• lactation period
• children up to 6 years old
• hypersensitivity to the components of the drug.

The drug should be used with caution in patients with liver failure.

Lopedium during pregnancy and breastfeeding

Not described.

Lopedium: instructions for use

The drug should be taken orally, tablets and capsules should be swallowed without chewing, with 100 ml of water.

Adults with acute and chronic diarrhea are prescribed initially 4 mg, then 2 mg after each act of defecation in case of loose stools. The maximum daily dose is 16 mg.

Children over 6 years of age are prescribed 2 mg after each bowel movement in case of loose stools. The maximum daily dose is 6 mg.

After normalization of stool or in the absence of stool for more than 12 hours, treatment should be discontinued.

Side effects

From the digestive system: gastralgia, dry mouth, nausea, vomiting, intestinal colic, constipation, very rarely - intestinal obstruction.

From the central nervous system: drowsiness or insomnia, dizziness, headache.

Allergic reactions: skin rash.

special instructions

Not described.

Compatibility with other drugs

Not described.

Overdose

Symptoms: central nervous system depression (stupor, loss of coordination, drowsiness, miosis, muscle hypertonicity, respiratory depression), intestinal obstruction.

Treatment: antidote - naloxone. Because loperamide has a longer duration of action than naloxone, repeated administration of the latter is possible. Symptomatic therapy is carried out (activated carbon, gastric lavage, mechanical ventilation). Medical observation of the patient is required for at least 48 hours.

Storage conditions and shelf life

In a dry place, protected from light, at a temperature not exceeding 25 °C.

Analogues and prices

Among foreign and Russian analogues of Lopedium there are:

Imodium. Manufacturer: Janssen-Cilag 564 rub.
Loperamide. Manufacturer: Ozone 21 rub.
Loperamide acry. Manufacturer: Akrikhin (Russia). Price in pharmacies from 55 rubles.
Diara. Manufacturer: Obolenskoe FP (Russia). Price in pharmacies from 98 rubles.

"Lopedium" is a drug that inhibits peristalsis. It is a gelatin capsule with a hard shell, colored gray or dark green (they contain a homogeneous whitish powder) or white tablets.

Pharmacological properties

Lopedium tablets (instructions for use are given in this article) consist of a substance that can bind to intestinal opiate receptors. Thanks to this connection, the release of acetylcholine and prostaglandins is suppressed. In this way, pulse peristalsis is reduced and the time period for food to pass through the digestive tract is significantly increased. Also, the intestinal walls absorb more fluid, and the sphincter muscles become toned.

Pharmacokinetics

Most of the loperamide that enters the body is absorbed in the intestine, however, due to the intensive first-pass metabolism, systemic bioavailability is only a quarter of a percent.

Thanks to research, it was found that the drug is distributed relative to the intestinal wall, and at the same time binds to the receptors of the longitudinal layer of the muscular layer. For the most part, loperamide binds to proteins, especially albumin.

Lopedium tablets (the instructions for use classify them as safe drugs) are almost completely absorbed by the liver, where they are metabolized, conjugated and excreted from the body with bile. Due to the very intense effect of the first passage of the drug through the liver, the concentration of the drug itself in the blood is significantly reduced, remaining very low. The drug is completely eliminated from the body in eleven to fourteen hours.

Indications for use

"Lopedium" (tablets) instructions for use recommends taking it in case of chronic and acute diarrhea. This drug can be taken by people who travel ("tourist's diarrhea"). In this case, the course of treatment should be two days. However, if blood is detected in the stool, you should not use the medicine until the cause of the illness is determined by your doctor.

Contraindications

You should not use the tablets if you have hypersensitivity to or any other components of the drug.

Main contraindications for patients:

Bacterial enterocolitis resulting from the activity of certain microorganisms:

Acute dysentery, accompanied by bloody diarrhea and elevated body temperature.

Combining the drug with any antibiotics should be done with extreme caution. You should definitely tell your doctor about this.

You should not use Lopedium tablets (the instructions for use warn patients) if you develop constipation, bloating or intestinal obstruction. Avoid this product if you want to avoid inhibition of peristalsis.

How to take Lopedium tablets

The drug can be used by adults and children over six years of age. The capsule (tablet) must be swallowed whole with a small amount of clean water.

For chronic and acute diarrhea, the dose for adults should be 4 mg of the drug (two pieces). One piece will be enough for children. The drug should be taken after each loose bowel movement. The maximum daily intake for children and adults is six to eight tablets.

If symptoms of acute diarrhea do not disappear within forty-eight hours, the drug should be discontinued.

Elderly patients do not need special adjustments to the dosage of capsules. The same applies to people suffering from kidney problems. Lopedium (tablets) instructions for use are not recommended for use in children 3 years of age.

Features of application

Typically, treatment for diarrhea is systematic. If the patient has the opportunity to determine the etymology of the disease, then in this case it is necessary to carry out specific treatment. It is possible that this drug is prescribed by doctors during the use of antibacterial therapy. In parallel with taking Lopedium (tablets), the instructions for use for children recommend replacement therapy to replenish electrolytes and fluids. This should be done if imbalance and dehydration of electrolytes occurs.

Patients diagnosed with acquired immunodeficiency syndrome (AIDS) with diarrhea should immediately stop taking Lopedium in case of bloating.

"Lopedium" (tablets): instructions for use during pregnancy and lactation

Doctors do not recommend taking the drug to pregnant and lactating women. This is because small amounts of loperamide may pass into breast milk. That is why pregnant women should definitely consult a doctor before purchasing the drug.

Interaction with other drugs

Scientists know of cases of interaction with drugs that have similar pharmacological characteristics. Medicines that have a depressant effect on the central nervous system cannot be combined with Lopedium.

It is worth considering that loperamide is a P-glycoprotein substrate. The simultaneous use of Lopedium, as well as quinidine and ritonavir, can lead to a significant increase in the concentration of the drug in the blood. The dose may increase two to three times. A similar effect is observed with the use of itraconazole and ketaconazole.

It was found that drugs with similar pharmacological properties can enhance the effect of loperamide several times. But medications that speed up the passage of contents through the gastrointestinal tract, on the contrary, reduce its effectiveness.

Overdose

Lopedium tablets (the instructions for use describe the symptoms of an overdose) can lead to loss of coordination, headache, drowsiness, stupor and urinary retention. If you experience similar symptoms, you can take Naloxone. In rare cases, the stomach is washed and activated carbon is drunk.

Adverse reactions

Skin rashes may develop, including Stevenson-Johnson syndrome; erythema multiforme; swelling; itching and hives.

The drug can also negatively affect the nervous system. Patients may experience drowsiness, incoordination, loss of consciousness, hypertension, and tremors.

From the digestive system, patients may notice dry mouth, constipation, nausea, flatulence, vomiting, and intestinal obstruction. Many patients experience fatigue.

Car drivers and those working with machinery should use the drug with extreme caution, as the medicine may cause drowsiness.

Release form, packaging and composition

Each capsule (tablet) contains two milligrams of loperamide hydrochloride. In addition to the main medicinal substance, the drug also contains auxiliary substances, namely: talc, magnesium stearate, corn starch and lactose monohydrate.

Tablets are sold in strips of ten pieces. The package can contain from one to five blisters.

The tablets are white and round in shape, convex on one side.

The drug should be stored in a dark, dry place out of reach of children. The temperature should not exceed twenty-five degrees. Shelf life is five years from the date of manufacture. The drug can be purchased at any pharmacy without a doctor's prescription. However, do not forget that self-medication can lead to negative consequences.