Does Mexidol need to be diluted for intramuscular administration? Mexidol ® injection solution

Mexidol injections can help with different situations related to problems nervous system, and not only. The list of indications for use is quite wide, but the decision on use is made solely by the doctor.

Composition, release form and packaging

Mexidol is produced both in tablets and in the form of a solution for injections. The last one looks like clear liquid, sealed in ampoules of 2 or 5 ml. The package usually contains five containers.

Each milliliter of medicine contains:

ethylmethylhydroxypyridine succinate (medicinal component) – 50 mg;
sodium metabisulfite;
water for injections.

This is a very popular drug. Especially for those who had to struggle with abnormalities in the functioning of the brain, including stroke survivors. However, the medicine has proven itself not only in neurology, but also in other areas of medicine, from psychiatry to surgery.

Pharmacological action and pharmacodynamics

Mexidol has phenomenal biological activity.

He:

activates metabolism;
improves the functioning of cell membranes;
normalizes cholesterol levels;
reduces symptoms of poisoning;
relieves cramps;
restores the electrical activity of the heart;
successfully combats anxiety and panic attacks;
helps to resist stress;
improves memory and ability to concentrate;
normalizes blood supply to the brain;
stops processes negative influence lack of oxygen affects the body.

The medicine quickly penetrates the body at the cellular level, giving the strength to resist situations caused by a lack of oxygen in the blood, including ischemia, hypoxia, and oxygen deficiency in the brain.

In addition, Mexidol is able to remove alcohol toxins and improve the poor health of a person suffering from withdrawal syndrome (the so-called complex of pathologies that arise in a chronic alcoholic due to sharp decline usual dose of alcohol or refusal from it). It also helps during operations for purulent processes in the peritoneum and helps with neurotic and neurotic-like conditions.

The introduction of "Mexidol" inhibits the formation of free radicals and strengthens the membranes of red blood cells, does not allow platelets to stick together into blood clots, reduces poisoning caused by acute pancreatitis when, due to inflammation of the pancreas, toxins begin to accumulate in the body.

When hypoxia decreases activity oxidative processes. By increasing coronary blood flow, it improves metabolism in the myocardium suffering from oxygen deficiency, directly in the area of ischemia. It also affects the retina and optic nerve, making vision sharper.

Main active ingredient the drug increases the content of dopamine (a neurotransmitter that allows you to feel pleasure, not feel pain and is responsible for motor function muscles) in the brain.

Why is the drug prescribed?

Injectable Mexidol is prescribed when an illness combining mental and physiological reasons occurrence. Can also act as the only one remedy, and as part of complex therapy.

It is prescribed for:

traumatic brain injuries and their consequences;
acute heart attack myocardium;
severe poisoning with antipsychotic drugs;
withdrawal syndrome;
withdrawal caused by drug addiction;
impaired blood circulation in the brain;
necrotizing pancreatitis;
peritonitis;
neurocirculatory dystonia (a set of disorders of the cardiovascular system);
discirculatory encephalopathy (damage to small arteries of brain tissue);
primary open-angle glaucoma in different stages;
persistent anxiety in a state of neurosis.

In addition, Mexidol is also used for elderly patients who suffer from senile atherosclerosis.

Instructions for the use of Mexidol injections

The scope of use of Mexidol in injections is quite wide. The dosage, regimen and duration of use are determined by the doctor in each specific case. It takes into account not only the disease and its severity, but also the age of the patient (for those under 12 years of age, the drug is not approved), and the characteristics of the course of the disease. Therefore, it may deviate from the standard recommendations outlined in the manual.

Usually on initial stage(the first five days) treatment resorts to the most effective way- inject Mexidol intravenously. Why dilute it with water for injection and place a dropper set at 40 - 60 drops per minute. Or injected into a vein with a syringe, slowly, from 5 to 7 minutes. The daily dose is calculated based on the patient's body weight. For every kilogram of weight there should be 7 - 9 ml of succinate.

The Mexidol treatment regimen is determined by the disease. For example:

problems with cerebral circulation: 200-300 ml per day (the first two to four days) intravenously, then 100 ml of Mexidol intramuscularly - three times a day;
injuries of the skull and brain: two weeks, two to four times a day, droppers of 200 - 500 ml are given;
decompensation of dyscirculatory encephalopathy, when protective forces the body is not able to stop the pathology: intravenously (injections or droppers) 100 ml twice or thrice a day;
myocardial infarction: in the first five days, drip into a vein with a 5% glucose solution or 0.9% sodium chloride solution (every eight hours), from the ninth day you can inject it intramuscularly. The upper threshold for a single dose is 250, daily dose is 800 ml;
glaucoma: one - three intramuscular injection per day 100 - 300 ml.

How long therapy will last depends on what disease is being treated. So:

to normalize the blood supply to the brain, Mexidol is used for 10 to 14 days;
for atherosclerosis, injections will have to be given for 30 or even 40 days;
for encephalopathy, the course of treatment is shorter - usually two weeks is enough;
in case of necrotizing pancreatitis, the task of Mexidol is to reduce the severity of manifestations. The timing varies in each individual case;
It may take 7-10 days to eliminate intoxication with antipsychotics.

In any case, you should not stop treatment suddenly. In order not to cause discomfort, the dose should be reduced gradually.

Can it be used during pregnancy and lactation?

Research into how Mexidol can affect pregnancy, whether it crosses the placental barrier, and whether it can penetrate into breast milk, has not been conducted. Therefore, experts do not take the risk of calling the drug safe for this category of patients and do not allow women who are pregnant or breastfeeding to use it. During pregnancy, it is unknown how the medicine may affect the development of the fetus. When feeding breast milk The mother needs to temporarily switch the child to artificial formula.

Drug interactions

Quite often, Mexidol is one of the components healing process and is used in parallel with other medications. The dose and duration of use of Mexidol often depend on how they interact.

In combination with it, the human body is more strongly influenced by:

anticonvulsants;
antidepressants;
nootropics;
neuroleptics;
tranquilizers;
benzodiazepine derivatives;
painkillers.

In general, it can be noted that there were no negative results associated with the combination of Mexidol with any other medicine. But you should tell your doctor when you are taking any other medications at the same time.

Compatibility of the drug with alcohol

Mexidol, as mentioned above, reduces the effect of the toxic components of alcohol on the body. However, this does not mean that alcohol is not a hindrance for him. After all, even if the components of both are completely compatible, alcoholic drinks contraindicated for diseases for which Mexidol is prescribed. Neglecting the ban can end very badly.

There are situations when Mexidol cannot be used under any circumstances:

age under 12 years;
exacerbation of chronic renal failure;
liver failure;
individual intolerance components.

Pregnancy and breastfeeding have already been discussed above.

In use of this medication Caution is needed for those who suffer from increased or low blood pressure. And also for people driving cars and working with other complex technology: can be adverse reactions, which slow down the ability to quickly concentrate, distract attention and make you sleepy.

In general, Mexidol is a low-toxic drug, so the list of undesirable effects is small.

Rarely likely:

attacks of nausea;
state of constant drowsiness;
dry mouth;
constipation or, conversely, diarrhea;
flatulence;
swelling and rash on the skin;
blood pressure surges;
deterioration of sleep.

If the dose is incorrect or the period of therapy is extended without permission, when an overdose occurs, the above phenomena may become more active. Heartburn and vomiting are also possible.

Analogues of Mexidol injections

In pharmacies you can find quite a lot of analogues of Mexidol injections with a similar chemical composition.

Among them:

"Mexibel";
"Cerekard";
"Mexico";
"Neurox";
"Mexifin";
"Mexidant."

The doctor may prescribe other substitutes that are similar in their effects.

Mexidol is an antioxidant agent.

Release form and composition

Mexidol is available in the following dosage forms:

Film-coated tablets: round, biconvex, pure white or cream-colored (10 pieces in blister packs, 3 or 5 packs in a cardboard box);
Solution for injection: transparent, colorless or with a slight yellowish tint (2 ml in glass ampoules, 5 ampoules in blister packs, 2, 4, 10 or 20 packs in a cardboard pack; 5 ml in glass ampoules, 5 ampoules in blister packs, in a cardboard pack 1, 4, 10 or 20 packs).

Active substance– ethylmethylhydroxypyridine succinate. Its content:

1 tablet – 125 mg;
1 ml of solution – 50 mg.

Auxiliary components of the tablets: magnesium stearate, sodium carboxymethylcellulose and lactose monohydrate.

Composition of the tablet coating: opadry II white (polyvinyl alcohol, titanium dioxide, talc and macrogol).

Auxiliary components of the solution: sodium metabisulfite and injection water.

Indications for use

For solution:

Encephalopathy;
Traumatic brain injuries and their consequences;
Acute disorders cerebral circulation;
Anxiety disorders caused by neurotic and neurosis-like conditions;
Acute intoxication antipsychotics;
Withdrawal syndrome in alcoholism with a predominance of vegetative-vascular and neurosis-like disorders (for relief);
Acute myocardial infarction (as part of complex therapy, from the first day);
Acute purulent-inflammatory processes abdominal cavity, such as peritonitis and acute necrotizing pancreatitis (as part of complex therapy);
Primary open-angle glaucoma (as part of combination therapy).

For tablets:

Mild traumatic brain injury, as well as the consequences of any traumatic brain injury;
Autonomic dystonia syndrome;
Encephalopathies of various origins(dysmetabolic, post-traumatic, dyscirculatory, mixed);
Mild cognitive disorders of atherosclerotic origin;
Anxiety disorders in neurotic and neurosis-like conditions;
Impact of stress (extreme) factors;
Conditions after acute intoxication antipsychotics;
Withdrawal syndrome in alcoholism with a predominance of vegetative-vascular and neurosis-like disorders (relief), as well as post-withdrawal disorders;
Asthenic conditions;
Coronary heart disease (as one of the drugs in complex therapy);
Consequences of acute cerebrovascular accidents in the subcompensation phase, incl. after transient ischemic attacks (as preventive courses);
Prevention of development somatic diseases under the influence of extreme loads and other factors.

Contraindications

The use of Mexidol is contraindicated in the following cases:

Acute renal and/or liver dysfunction;
Hypersensitivity to the components included in the drug.

Due to insufficient data on effectiveness and safety, the drug is not recommended for use in children, pregnant and breastfeeding women.

Directions for use and dosage

Mexidol solution is intended for intramuscular (IM) and intravenous (IV) jet or drip administration. For cooking infusion solution 0.9% sodium chloride solution is used as a solvent.

The drug is administered intravenously: drip - at a rate of 40-60 drops per minute, stream - for 5-7 minutes. Maximum permissible daily dose is 1200 mg.

Acute intoxication antipsychotic drugs: IV 200-500 mg per day for 7-14 days;
Traumatic brain injuries and their consequences: intravenous drip at a dose of 200-500 mg 2-4 times a day for 10-15 days;
Acute cerebrovascular accidents: in the first 10-14 days - intravenous drip at a dose of 200-500 mg 2 to 4 times a day, over the next 2 weeks - intramuscularly at a dose of 200-250 mg 2-3 times a day day;
Decompensated discirculatory encephalopathy: 200-500 mg intravenously or in a stream 1-2 times a day for 14 days, over the next 2 weeks - 100-250 mg intramuscularly per day;
Prevention of dyscirculatory encephalopathy: 200-500 mg intramuscularly 2 times a day, course – 10-14 days;
Mild cognitive impairment in older people and anxiety disorders: IM 100-300 mg per day for 14-30 days;
Open-angle glaucoma: 100-300 mg IM 1-3 times a day. Duration of treatment – 14 days;
Alcohol withdrawal syndrome: IV drip or IM at a dose of 200-500 mg 2-3 times a day for 5-7 days;
Acute purulent-inflammatory processes of the abdominal cavity: the dose is determined individually depending on the form and severity of the disease, the prevalence of the inflammatory process and variants clinical course. Mexidol is discontinued gradually after achieving a stable positive clinical and laboratory effect;
Acute edematous pancreatitis: IV drip (in sodium chloride solution) and IM 200-500 mg 3 times a day;
Necrotizing pancreatitis mild degree: IV drip (in sodium chloride solution) and IM 100-200 mg 3 times a day;
Moderate necrotizing pancreatitis: intravenous drip (in sodium chloride solution) 200 mg 3 times a day;
Severe necrotizing pancreatitis: on the first day a pulse dosage of 800 mg is prescribed, then 200-500 mg 2 times a day with gradual decline daily dose;
An extremely severe form of necrotizing pancreatitis: intravenous drip (in sodium chloride solution), the initial daily dose is 800 mg, after persistent relief of the manifestations of shock and stabilization of the condition - 300-500 mg 2 times a day with a gradual decrease in the daily dose;
Acute myocardial infarction (in addition to traditional therapy, including beta-blockers, nitrates, angiotensin-converting enzyme inhibitors, thrombolytics, antiplatelet and anticoagulant drugs, as well as symptomatic remedies according to indications): during the first 5 days, it is advisable to administer the drug intravenously to achieve maximum effect, the next 9 days - possible intramuscularly. General course treatment – 14 days. IV administration is carried out by slow drip infusion. Mexidol is diluted in 100-150 ml of 5% dextrose solution or 0.9% sodium chloride solution and administered over 30-90 minutes. If necessary, slow jet injection for at least 5 minutes. The frequency of use of the drug is 3 times a day at intervals of 8 hours. Single dose – 2-3 mg/kg, but not more than 250 mg, daily dose – 6-9 mg/kg, but not more than 800 mg.

Mexidol tablets should be taken orally. Depending on the indications, 125-250 mg is prescribed 3 times a day.

For cupping alcohol withdrawal 5-7 days are enough. In other cases, the duration of treatment is 2-6 weeks. The drug is discontinued gradually, reducing the dose over 2-3 days.

The minimum duration of treatment for coronary heart disease is 1.5-2 months. Can be carried out as prescribed by a doctor repeat courses(preferably in spring and autumn).

Side effects

In general, Mexidol is well tolerated. Sometimes individual side effects of a dyspeptic nature occur. Allergic reactions and drowsiness are possible.

In some patients, especially those with bronchial asthma and if available hypersensitivity to sulfites, there is a possibility of developing severe hypersensitivity reactions.

special instructions

Mexidol goes well with everything medicines, which are traditionally used in the treatment of somatic diseases.

Drug interactions

Ethylmethylhydroxypyridine succinate enhances the effect of anticonvulsants and antiparkinsonian drugs, anxiolytics, antidepressants, and benzodiazepine derivatives.

Reduces the toxic effect of ethanol.

Terms and conditions of storage

Do not expose to light or moisture. Store at a temperature not exceeding 25 ºС. Keep away from children.

Shelf life – 3 years.

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"Mexidol" is domestic drug new generation with antioxidant effect. Due to the fact that this medicine normalizes metabolic processes in the body and protects cells from exposure free radicals, it has wide range applications. Most often, Mexidol is used in neurology, narcology, and surgery. But this drug is capable of normalizing the functioning of almost all organs and systems. Despite these properties, not everyone can use Mexidol in treatment. Contraindications to its use limit its frequent use. The drug has not yet been studied much, since it has only been widely used since 2003.

Characteristics of the drug

The development of this product began in the 80s, but in medical practice Mexidol was introduced only 20 years later. Scientists received a prize for creating such unique drug. Mexidol is now recognized the best remedy V neurological practice. Its properties make it possible to alleviate the patient’s condition in many diseases, to use it for prevention, as well as for the relief of acute neurological disorders and intoxications. The drug is available in tablets and solution for injection. It can be purchased at the pharmacy only with a prescription. After all, when prescribing the drug "Mexidol", its contraindications must be taken into account.

Properties of the drug

The main active ingredient of the drug is ethylmethylhydroxypyridine succinate. This substance actively participates in all metabolic processes in the body, normalizing them. Therefore, the drug regulates the functioning of many organs and systems. Normalization of metabolism in the body occurs due to the fact that the active substance of the drug has the following properties:

suppresses the activity of free radicals and protects cells from their effects;
reduces the oxygen needs of cells, which allows tissues to more easily tolerate hypoxia;
improves the condition of the walls of blood vessels;
stabilizes the membranes of red blood cells and platelets, preventing the formation of blood clots and preventing the destruction of blood cells;
improves the condition of brain cells and mental abilities;
regulates the action of the autonomic nervous system;
protects brain cells from damage;
enhances the effect of tranquilizers, sleeping pills, antidepressants and antipsychotics, which makes it possible to reduce their dosage.

Features of the action

Before prescribing Mexidol, the doctor must take into account contraindications. But the low toxicity of the drug allows it to be used in many cases. Wide use This remedy was received due to the peculiarities of its effect on the patient’s body:

normalizes blood circulation;
improves blood supply and tissue nutrition;
increases the degree of concentration;
improves memory;
normalizes blood cholesterol levels;
increases hemoglobin levels;
stimulates the production of the hormone dopamine;
relieves headaches;
restores the functioning of the heart muscle;
increases the body's resistance to stress;
normalizes the composition and properties of blood, improves its fluidity;
restores normal sleep;
slows down the aging process of the body.

Indications for use

Despite the fact that the drug appeared recently, the range of its use is quite wide. Doctors of various specialties prescribe Mexidol to their patients. Application and contraindications allow its use in the following cases:

after traumatic brain injury;
in case of cerebrovascular accident;
for epilepsy, Alzheimer's and Parkinson's diseases;
V complex treatment hypertension, atherosclerosis and coronary heart disease;
with frequent headaches;
for depression, stress, neuroses and other neuropsychic disorders;
during recovery from a stroke or myocardial infarction;
with hypoxia, shock;
at alcohol intoxication and withdrawal syndrome;
for acute inflammatory processes in the abdominal cavity, for example, pancreatitis.

The drug "Mexidol": contraindications

Side effects of this drug are rare, which makes it suitable for many patients. But nevertheless, this medicine also has contraindications. First of all, this is individual intolerance. Therefore, before using it, it is advisable to conduct a test for allergic reaction. In addition, the drug "Mexidol" has the following contraindications:

children under 14 years of age due to insufficient knowledge of the drug;
pregnancy and lactation;
renal dysfunction, inflammatory diseases;
any liver disease, especially hepatitis;
high blood pressure;
the drug should be used with caution in patients with bronchial asthma.

Features of the use of tablets

After the acute condition subsides and mild flow diseases "Mexidol" is prescribed orally. The peculiarity of the drug is that it can be used long time- up to 3 months. At the same time, its effect does not decrease, side effects and withdrawal syndrome do not develop. Mexidol (tablets) is often prescribed to elderly patients. Contraindications must be taken into account, since the drug is poorly tolerated in high blood pressure And serious violations in the functioning of the liver or kidneys. Tablets are usually taken 1-2 pieces 3 times a day. The duration of treatment ranges from 5 days to 2 months. Moreover, the drug should be discontinued with a gradual reduction in dosage. At long-term use the risk of manifestation does not increase side effects, if all contraindications have been taken into account.

"Mexidol": injections

At acute conditions the drug is used in the form of injections. It is administered intramuscularly or intravenously. The dosage is determined individually. But a maximum of 0.8 g should not be administered per day. The active substance is quickly absorbed and distributed in the tissues. Its properties last for 4-5 hours, so the medicine is prescribed 2-3 times a day. Most often in narcological, neurological and surgical departments In hospitals, injections of the drug "Mexidol" are used. Side effects and contraindications must be taken into account.

At purulent processes in the abdominal cavity - pancreatitis, peritonitis, with severe intoxication and acute disorders cerebral circulation, the drug is administered by drip or stream intravenously. For milder cases of the disease, as well as for the treatment of alcoholism, senile dementia or Parkinson's disease are used intramuscular injections. The course of treatment in this way usually lasts from 3 to 10 days. But sometimes therapy continues for up to a month, and then switches to oral administration drug.

Side effects

TO positive properties The drug is that it is not addictive, it can be canceled at any time without fear of consequences. But since Mexidol has recently been used, contraindications, side effects and features of its use for various diseases still little studied. The drug is considered safe and has almost no toxic effect on the body. The only side effects observed were:

allergic reactions due to individual intolerance;
nausea, dryness and intravenous administration;
severe drowsiness, impaired coordination of movements and decreased activity in case of overdose.

All these consequences pass quickly and usually do not require discontinuation of the drug, with the exception of allergic reactions.

Use of the drug in sports

Mexidol's ability to regulate metabolic processes in the body allows it to be used by athletes. But even these people are prescribed the drug by a doctor. One should take into account such a feature of this remedy as a decrease in the level of the hormone cortisol. It is formed when physical activity and promotes the active release of glucose from the liver. This leads to increased performance and endurance, which is necessary during training. Only in some athletes the level of cortisol is constantly increased, which causes headaches, insomnia, and increased blood pressure. In this case, the doctor prescribes Mexidol, the dosage and features of its use are chosen strictly individually.

Treatment of alcoholism

In narcology, the drug "Mexidol" is often used. Its use and contraindications in this area have been studied quite well. And this remedy is considered one of the best for treating alcoholism. "Mexidol" not only removes toxins and relieves intoxication. It helps stop withdrawal syndrome, restores autonomic functions, used for behavioral disorders. The advantages of its use include that it is compatible with ethanol and even reduces it toxic effects, allowing the patient to gradually give up alcohol. Treatment lasts from 2 weeks to 2 months, and drug withdrawal should be gradual.

APPROVED

By order of the chairman
Committee for Control of Medical and

Pharmaceutical activities
Ministry of Health

Republic of Kazakhstan

From "____"______________201__

№ ______________

Instructions for medical use

Medicine

MEXIDOL®

Tradename

Mexidol®

International generic name

Dosage form

Solution for intravenous and intramuscular injection 50 mg/ml 2 ml or 5 ml

Compound

1 ml of solution contains

Active substance: ethylmethylhydroxypyridine succinate - 50 mg,

Excipients: sodium metabisulfite, water for injections

Description

Transparent colorless or slightly yellowish liquid

Pharmacotherapeutic group

Drugs for the treatment of diseases of the nervous system are different.

ATX code N07XX

Pharmacological properties

Pharmacokinetics

When administered intramuscularly, the drug is detected in the blood plasma for 4 hours after administration. The time to reach maximum concentration is 0.45 - 0.50 hours. The maximum concentration at doses of 400 - 500 mg is 3.5 - 4.0 mcg/ml. Mexidol® quickly passes from the bloodstream into organs and tissues and is quickly eliminated from the body. The retention time (MRT) of the drug in the body is 0.7 - 1.3 hours. The drug is excreted from the body in the urine mainly in glucurone-conjugated form and in small quantities unchanged.

Pharmacodynamics

It has antihypoxic, membrane-protective, nootropic, anticonvulsant, anxiolytic effects, and increases the body's resistance to stress. Mexidol® increases the body's resistance to the effects of major damaging factors, oxygen-dependent pathological conditions(shock, hypoxia and ischemia, cerebrovascular accident, intoxication with alcohol and antipsychotic drugs (neuroleptics)).

Mexidol® improves cerebral metabolism and blood supply to the brain, improves microcirculation and rheological properties blood, reduces platelet aggregation. Stabilizes the membrane structures of blood cells (erythrocytes and platelets) during hemolysis. Has a hypolipidemic effect, reduces the level total cholesterol and low-density lipoproteins (LDL).

Reduces enzymatic toxemia and endogenous intoxication in acute pancreatitis.

The mechanism of action of Mexidol® is due to its antihypoxic, antioxidant and membrane protective effects. It inhibits the processes of lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity, and increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, gamma-aminobutyric acid(GABA), acetylcholine), which enhances their ability to bind to ligands, helps preserve the structural and functional organization of biomembranes, transport of neurotransmitters and improve synaptic transmission. Mexidol® increases dopamine levels in the brain. Causes an increase in the compensatory activity of aerobic glycolysis and a decrease in the degree of inhibition of oxidative processes in the Krebs cycle under hypoxic conditions, with an increase in the content of adenosine triphosphate (ATP), creatine phosphate and activation of the energy-synthesizing functions of mitochondria, stabilization of cell membranes.

Mexidol® normalizes metabolic processes in ischemic myocardium, reduces the area of necrosis, restores and improves the electrical activity and contractility of the myocardium, and also increases coronary blood flow in the ischemic zone, reduces the consequences of reperfusion syndrome in acute coronary insufficiency. Increases the antianginal activity of nitro drugs. Mexidol® helps preserve retinal ganglion cells and fibers optic nerve with progressive neuropathy, the causes of which are chronic ischemia and hypoxia. Improves functional activity retina and optic nerve, increasing visual acuity.

Indications for use

Acute cerebrovascular accidents

Traumatic brain injury, consequences of traumatic brain injury

Encephalopathy

Vegetative-vascular dystonia

Mild cognitive impairment of atherosclerotic origin

Anxiety disorders in neurotic and neurosis-like conditions

Acute myocardial infarction (from the first day) as part of complex therapy

Primary open-angle glaucoma of various stages, as part of complex therapy

Relief of withdrawal syndrome in alcoholism with a predominance of neurosis-like and vegetative-vascular disorders

Acute intoxication with antipsychotic drugs

Acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis) as part of complex therapy

Directions for use and doses

Intramuscularly or intravenously (stream or drip). When administered by infusion, Mexidol® should be diluted in a 0.9% sodium chloride solution. Mexidol® is administered in a stream slowly over 5 - 7 minutes, dropwise - at a rate of 40 - 60 drops per minute. The maximum daily dose should not exceed 1200 mg.

For acute cerebrovascular accidents, Mexidol® is used in the first 10 - 14 days - intravenously 200 - 500 mg 2 - 4 times a day, then intramuscularly 200 - 250 mg 2 - 3 times a day for 2 weeks.

For traumatic brain injury and the consequences of traumatic brain injuries, Mexidol® is used intravenously for 10 - 15 days, 200 - 500 mg 2 - 4 times a day.

For discirculatory encephalopathy in the decompensation phase, Mexidol® should be prescribed intravenously in a stream or drip at a dose of 200 - 500 mg 1 - 2 times a day for 14 days. Then intramuscularly at 100 - 250 mg per day for the next 2 weeks.

For mild cognitive impairment in elderly patients and anxiety disorders Mexidol® is used intramuscularly at a daily dose of 100 - 300 mg per day for 14 - 30 days.

In case of acute myocardial infarction, as part of complex therapy, Mexidol® is administered intravenously or intramuscularly for 14 days, against the background of traditional therapy for myocardial infarction, including nitrates, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic means according to indications. In the first 5 days, to achieve maximum effect, it is advisable to administer Mexidol® intravenously; for the next 9 days, Mexidol® can be administered intramuscularly. Intravenous administration of Mexidol® is carried out by drip infusion, slowly (to avoid side effects) in a 0.9% sodium chloride solution or 5% dextrose (glucose) solution in a volume of 100 - 150 ml for 30 - 90 minutes. If necessary, a slow stream injection of Mexidol® is possible, lasting at least 5 minutes.

Administration of Mexidol® (intravenous or intramuscular) is carried out 3 times a day, every 8 hours. Daily allowance therapeutic dose is 6 - 9 mg per kg of body weight per day, single dose— 2 ̶ 3 mg per kg body weight. The maximum daily dose should not exceed 800 mg, single dose - 250 mg.

For open-angle glaucoma of various stages, as part of complex therapy, Mexidol® is administered intramuscularly at 100 - 300 mg per day, 1 - 3 times a day for 14 days.

With withdrawal symptoms alcohol syndrome Mexidol® is administered in a dose of 200 - 500 mg intravenously or intramuscularly 2 - 3 times a day for 5 - 7 days.

In case of acute intoxication with antipsychotic drugs, Mexidol® is administered intravenously at a dose of 200 - 500 mg per day for 7 - 14 days.

In acute purulent-inflammatory processes of the abdominal cavity (acute necrotizing pancreatitis, peritonitis), Mexidol® is prescribed on the first day both preoperatively and during postoperative period. The administered doses depend on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. Mexidol® should be discontinued gradually only after a stable positive clinical and laboratory effect.

For acute edematous (interstitial) pancreatitis, Mexidol® is prescribed 200 - 500 mg 3 times a day, intravenously (in 0.9% sodium chloride solution) and intramuscularly.

Mild severity of necrotizing pancreatitis - 100 - 200 mg 3 times a day intravenously (in 0.9% sodium chloride solution) and intramuscularly. Average degree severity - 200 mg 3 times a day, intravenously (in 0.9% sodium chloride solution). Severe course - in a pulse dosage of 800 mg on the first day, with a two-fold administration regimen; then 200 - 500 mg 2 times a day with a gradual reduction in the daily dose.

Extremely severe course- at an initial dosage of 800 mg per day until persistent relief of the manifestations of pancreatogenic shock, upon stabilization of the condition, 300 - 500 mg 2 times a day intravenously (in 0.9% sodium chloride solution) with a gradual decrease in the daily dosage.

Side effects

Nausea and dry mouth, metallic taste in the mouth

Drowsiness

Allergic reactions

Unpleasant odor, sore throat and chest discomfort.

Indications for performing injections of such modern nootropic drug, like Mexidol, are quite extensive. They are connected with the most different areas medicine. And it is quite natural that the product is of interest to many categories of consumers, even those who do not have any serious problems with the activity of the brain and nervous system.

To understand in which cases Mexidol injections are most effective, the use of such a drug needs to be considered in detail.

The main effect of Mexidol, as noted earlier, is associated with its nootropic effect. The product has primarily a stress-protective effect. Included pharmacological product there is one active substance with complex name– ethylmethylhydroxypyridine succinate. It has a whole set of properties that can improve brain activity, prevent sclerotic processes, and improve cerebral circulation.

That is, Mexidol can be used primarily for preventive purposes. But it is also prescribed after a stroke and for initial stages atherosclerosis. If we take into account the specific effects of injections on the body, we can present the indications for taking the drug as follows:

history of stroke and ischemic disease in combination with other drugs;
previous traumatic brain injuries, mild concussion;
dysfunction of the circulatory system (for example, VSD);
deterioration of cognitive functions due to past diseases and age-related changes;
neuroses that cause increased anxiety or feeling of fear;
pronounced irritability due to accumulated or sudden stress;
consequences of use narcotic substances and alcohol.

As you can now see, Mexidol injections have very different indications for use. For this reason, the drug is often prescribed not only to sick people, but also for preventive purposes. The product helps maintain high performance, protects against stress factors and deterioration of brain activity due to exhaustion or consumption of alcoholic beverages.

“Side” consequences of using Mexidol include improving memory, increasing cognitive functions, and relieving emotional stress. Thus, even completely healthy people this drug may be prescribed. True, it must be used correctly to achieve this effect. If you still want to try Mexidol, instructions for use, price, reviews, analogues and other interesting aspects should be clarified in advance.

Instructions for using Mexidol injections

A standard package of the drug contains 5–10 ampoules of 2 ml. Injections are given only intramuscularly. Intravenous administration is permissible only in a hospital setting using a dropper. Intravenous injection is acceptable. But, again, only under the supervision of a specialist. At home the best option use is to perform intramuscular injections in the buttock.

For Mexidol injections, the instructions for use are no different in complexity. But in each case, the dosage, frequency and duration of use of the drug must be determined by the doctor. Mexidol should be used independently only for preventive purposes to avoid anxiety disorders and decreased mental abilities.In this situation, the following rules should be considered.

The maximum dosage of Mexidol for intramuscular administration is 600 mg per day. But it’s better to start with a dosage of 200 mg per day. Only if there is no result, the dose is increased over time. It should be noted that the ampoules of the drug contain different proportions active substance. The most common is Mexidol 5%. But, if you plan to use maximum dosage means, it is worth purchasing Mexidol 10% ampoules.
The daily dosage of the drug is divided into 2 injections - morning and evening. Mexidol injections are usually easily tolerated. Administration of the drug does not cause painful sensations or burning sensation. It is no coincidence that doctors often prescribe the drug even to children under 12 years of age, and in exceptional cases, to infants.
The prophylactic course lasts 10–14 days. It is impossible to give injections of the drug for longer without the supervision of a doctor. If you want to enhance the effect, after this period it is better to switch to the tablet form of the medicine. Again, this is only possible if there are no side effects.

Patients usually treat the intramuscular administration of Mexidol with caution, because they consider this method to be ineffective. But experts say that there is little difference in the results between intramuscular and intravenous administration No. One has only to note that the most pronounced results can be obtained by performing injections together and taking Mexidol tablets.

No matter how simple the instructions for use for Mexidol injections may seem, reviews turn out to be much more useful than “dry” recommendations from specialists. Now this drug is often prescribed, so enough reviews have accumulated to draw conclusions about the effectiveness of the injections. It is worth seeing exactly how patients respond to the use of the drug.

Reviews about the use of Mexidol injections

“I got rid of constant migraines”

The doctor prescribed a course of Mexidol for the reason that I was constantly having headaches. I had migraines almost all the time for two months, without stopping. Then they gave injections of the medicine intramuscularly for two weeks. I didn’t feel any particular inconvenience. Only at first dizziness appeared about half an hour after administration. But then the headaches began to subside. After the course, migraines appeared very rarely - maybe once a month, no more. Therefore, I can say for sure that Mexidol helped. Life has become much easier.

“Simply incredible effect”

About six months ago I was diagnosed with cerebrovascular insufficiency. Some people might be scared by this name. But in fact, the disease manifests itself only in periodic dizziness and headaches... Be that as it may, they prescribed a course of Mexidol intramuscularly. I'm simply amazed at the results you can get from using it! Judge for yourself - after almost every injection I felt better. Not only did the pain go away, but my hearing also improved. I have much more strength to work. The mood is also high. In general, the impressions are the most positive. I just want to warn you that it is not advisable to use this product yourself. It's better to go to the doctor first and get a consultation.

“I coped with apathy and normalized sleep”

I have been plagued by hypotension since a young age. Constant sleepiness– this is familiar to me. But in Lately it got worse and worse. Apathy appeared, I didn’t want to do anything. I even felt that I was starting to have trouble “thinking”—everything was falling out of my hands, and I couldn’t work effectively. Mexidol injections saved me. The doctor prescribed them as a supportive remedy. I read the indications for use for Mexidol injections, and also studied the reviews in advance. And I started using it. Here are the changes that happened after a couple of weeks:

drowsiness completely disappeared throughout the day;
I started sleeping as per the schedule - no problems with falling asleep and waking up;
my head became completely clear and I began to cope with things easily;
appeared positive attitude, which has never happened before.

In general, as you can imagine, I am completely satisfied. At home, of course, it is inconvenient to give injections. But, if you have someone to do it, then you can definitely do it. Just inject it a couple of times a day, and after 2 weeks you are already a completely new person.

Mexidol injections are a useful drug when prescribed by a doctor

Mexidol should not be considered as some harmless “vitamins”. This is a powerful nootropic, independent use which does not always lead to positive consequences. Before using the medicine, it is not enough to read the instructions. You should also visit a specialist who will give comprehensive recommendations for admission. In this case, you can guarantee that the results from Mexidol injections will be excellent.