Sulfadimezin who gives children. Sulfadimezin - instructions, indications, use

Sulfadimezin - a drug that is part of the group of sulfanilamide antibacterial drugs intended for the treatment infectious pathology caused by sensitive pathogenic microflora. Especially for readers of "Popular about Health" I will consider the description of this remedy.

So, the instruction Sulfadimezin:

Composition Sulfadimezin and release form

Active substance in the drug Sulfadimezin is represented by sulfadimidine, the content of which is 500 milligrams. Auxiliary components: stearic acid, talc, polysorbate 80, potato starch.

The drug is available in white tablets with a slight yellow tint, flat cylindrical shape with a chamfer around the perimeter and a risk in the middle. There are 10 pieces in one package. The medicine is sold by prescription.

Pharmacological action Sulfadimezin

Antimicrobial action, the effect of which is bacteriostatic in nature. The principle of action of the active substance of the drug (sulfadimidine) is based on the suppression of the processes of folate biosynthesis, which disrupts the processes of bacterial division.

The following gram-positive and gram-negative microorganisms are susceptible to the drug: Klebsiella spp., Corynebacterium diphtheriae, Bacillus anthracis, Escherichia coli, Shigella spp., Actinomyces israelii, Chlamydophila, Clostridium paraperfringens, Toxoplasma gondii., Vibrio cholerae, Yersinia pestis.

Taking tablets of the drug Sulfadimezin contributes to a decrease in the population pathogenic bacteria, which reduces the duration of the course of infectious pathology and reduces the duration of the recovery period.

When administered orally, sulfadimidine is rapidly absorbed from the intestine, mainly in small intestine. The absorbed drug penetrates most of the tissue barriers. Maximum concentrations active ingredient defined in following bodies: kidneys, cerebrospinal fluid, intestinal walls, tissues of the lung and bronchi, mucous membrane of the oropharynx and paranasal sinuses, anatomical formations middle ear, bile ducts.

The half-life of the drug is 5 to 7 hours. Sulfadimidine undergoes intensive processes of metabolism in the liver. Its derivatives are excreted from the body with urine. With fluid deficiency, the formation of crystals of metabolites is possible. active substance in urinary tract.

Indications Sulfadimezin for use

The use of the antimicrobial drug Sulfadimezin is indicated in the presence of infectious lesions the following bodies:

Paranasal sinuses;
Middle ear;
Intestines;
urinary tract;
Bronchi and lungs;
Skin and soft tissues.

Any antibacterial drugs should be prescribed by a specialist whose duties include calculating effective dosage and determining the timing of the upcoming treatment.

Contraindications Sulfadimezin for use

Taking Sulfadimezin tablets is contraindicated in the following cases:

intolerance to sulfadimidine or auxiliary components medicines;
Pathology of hematopoiesis;
lactation period;
Porfiria;
Pregnancy;
Age less than 3 years;
Chronic kidney failure;
Hyperbilirubinemia in children.

Relative contraindications: any renal dysfunction, aggravated allergic history.

Sulfadimezin application and dosage

The drug is intended for oral administration. During treatment, patients should drink more fluids (if there are no contraindications). Taking pills does not depend on food.

For an adult patient, a dosage of 1 to 2 grams is recommended, with a frequency of up to 6 times a day. After the subsidence clinical manifestations treatment should be continued for some more time (to be agreed with the doctor), but already at a dosage of 1 gram per dose.

Overdose Sulfadimezin

With an overdose of the drug, salt crystals may appear in the urinary tract. Treatment consists of drug withdrawal, significant amount fluids, as well as other activities that contribute to the dissolution of urinary stones.

Side effects of Sulfadimezin

Antimicrobial therapy using the drug Sulfadimezin may be accompanied by the following side effects: diarrhea, nausea, vomiting, changes in blood laboratory parameters, allergic reactions on the skin, the appearance of salt crystals in the urine.

special instructions

The combination of the drug Sulfadimezin together with pharmaceuticals containing ascorbic acid dramatically enhances the processes of stone formation in the urinary tract. For this reason, it is better not to combine taking multivitamins with sulfanilamide antibiotic therapy.

Antacids may reduce the effectiveness of the drug. If necessary sharing you should create at least a 2-hour break between prima medicines.

Sulfadimezin's analogs

There are no analogues to the drug Sulfadimezin.

Conclusion

Antibacterial drugs should be taken under the supervision of a doctor, with the obligatory observance of the terms of treatment and recommended dosages. In addition, to prevent the spread of infection, the patient must comply with the medical and protective regimen.

Sulfadimezin- sulfa drug short action. Active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella, Klebsiella, Vibrio cholerae, pathogens gas gangrene, anthrax, diphtheria, catarrhal pneumonia, plague, as well as chlamydia, actinomycetes, pathogens of toxoplasmosis. Acts bacteriostatically. The mechanism of action is associated with para-aminobenzoic acid (PABA) and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines.

Pharmacokinetics

.
Rapidly absorbed from gastrointestinal tract(mainly in small intestine), is 75-86% bound to plasma proteins. It penetrates well into tissues and body fluids (including lungs, cerebrospinal fluid), is quickly excreted from the body, the half-life is 7:00; elimination is carried out mainly by the kidneys glomerular filtration. It undergoes biotransformation (acetylation) in the liver, acetylated metabolites may precipitate when concentrated in the urine. The solubility of metabolites is improved by alkalinization of urine.

Indications for use

A drug Sulfadimezin used to treat infections caused by susceptible microorganisms: infections respiratory tract and ENT organs (bronchitis, pneumonia, tonsillitis, sinusitis, otitis media); inflammatory diseases bile and urinary tract; skin and soft tissue infections (wound infection, pyoderma, erysipelas); gonorrhea, trachoma; shigellosis; toxoplasmosis.

Mode of application

Sulfadimezin take inside.
The average dose for adults is 2 g (4 tablets) at the first dose, then 1 g (2 tablets) 4-6 times a day.
Higher doses for adults: single - 2 g, daily - 7 g.
For children over the age of 3 years, prescribe 0.1 g / kg of body weight at the first dose, then 0.025 g / kg of body weight every 4-6-8 hours.
In the treatment of shigellosis, the drug is prescribed for adults according to the scheme:
1-2nd day - 1 g 6 times a day (every 4:00)
3-4th day - 1 g 4 times a day (every 6:00)
5-6th day - 1 g 3 times a day (every 8:00).
Total for the course of treatment - 25-30 g of the drug.
After a 5-6-day break, a second course of therapy is prescribed:
1-2nd day - 1 g 5 times a day (every 4 hours, and at night - after 8:00)
3-4th day - 1 g 4 times a day (do not take at night)
5th day - 1 g 3 times a day.
During the second course, 21 g of sulfadimesine are taken. At easy course for shigelosis, the dose can be reduced to 18 g.
Doses for the treatment of shigellosis from 3 years of age single dose- from 0.4 g to 0.75 g, which should be taken 4 times a day. The drug should be taken within 5-7 days. For most infectious diseases, treatment continues for at least another 48-72 hours after the disappearance of the symptoms of the disease and confirmation of recovery by the results of bacteriological analysis.
Children. The drug should be used in children over 3 years of age.

Side effects

Possible the same adverse reactions as with other sulfonamides.
Digestive system: abdominal pain, dyspeptic symptoms, including nausea, vomiting, diarrhea, anorexia; stomatitis, sialadenitis, pancreatitis, pseudomembranous colitis.
Hepatobiliary system: increased serum levels of hepatic transaminases, hepatomegaly, jaundice, hepatitis, hepatonecrosis is possible.
Nervous system: headache, neurological reactions, including aseptic meningitis, ataxia, qualitative intracranial hypertension, convulsions, dizziness, drowsiness / insomnia, fatigue, peripheral or optic neuropathy, tinnitus.
Mental disorders: depression, psychoses, hallucinations.
Immune system: hypersensitivity reactions, incl. itch, skin rashes(including urticaria), drug fever, chills, photosensitivity, exfoliative dermatitis, toxic epidermal necrolysis (Lyell's syndrome), erythema nodosum, erythema multiforme, erythroderma, fixed drug erythema, Stevens-Johnson syndrome, serum syndrome, periorbital edema, anaphylactic reactions, incl. angioedema, very rarely - anaphylactic shock. In addition, cases of allergic myocarditis have been reported, periarteritis nodosa, systemic lupus erythematosus / lupus-like syndrome.
Blood and lymphatic system: very rarely - agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, eosinophilia, acute hemolytic anemia with deficiency of glucose-6-phosphate dehydrogenase, purpura, hypoprothrombinemia, methemoglobinemia.
Urinary system: crystalluria (possibly with back pain, hematuria, oliguria, anuria), the risk of which can be reduced by using the drug with a sufficient amount of liquid, urine alkalinization is treated nephrotoxic reactions: interstitial nephritis, tubular necrosis, renal failure. Increasing the level of urea, creatinine in the blood serum.
Endocrine system: hypothyroidism, hypoglycemia.
Respiratory system: cough, sore throat, shortness of breath, pulmonary eosinophilic infiltrates, fibrosing alveolitis.
Others: tachycardia, arteritis, vasculitis, joint pain, muscle pain.
If adverse reactions occur, you should immediately stop taking the drug.

Contraindications

Contraindications to the use of the drug Sulfadimezin are: hypersensitivity to sulfadimidine or other components of the drug; a history of toxic-allergic reactions to other sulfonamides or their derivatives; systemic diseases blood, oppression of bone marrow hematopoiesis, incl. anemia, leukopenia; severe violations of the liver and / or kidney function, renal and / or liver failure; acute porphyria; hyperthyroidism; azotemia; deficiency of glucose-6-phosphate dehydrogenase (possible hemolysis).

Pregnancy

Application of the drug Sulfadimezin during pregnancy is contraindicated.
If necessary, the use of the drug during breastfeeding breast-feeding should be stopped.

Interaction with other drugs

Cyclosporine - a decrease in plasma concentrations of the latter is possible; increased risk development of nephrotoxicity.
Antithrombotics, anticoagulants indirect action(including phenindione, warfarin) - with simultaneous application their anticoagulant effect is enhanced.
General anesthetics (thiopental) - enhancing the effects of thiopental.
Pyrazolone derivatives, indomethacin and salicylates: increased activity and toxicity of sulfonamides.
Other non-steroidal anti-inflammatory drugs, sulfonylurea derivatives (including oral antidiabetic drugs), phenytoin - it is possible to increase their concentration in blood plasma, increase therapeutic action and increased risk of developing side effects. It may be necessary to adjust the dose of these drugs, incl. oral antidiabetic drugs.
Clozapine and other potentially hematotoxic drugs (for example, chloramphenicol, thiamazole, mercazolil) - the risk of hematotoxicity increases, incl.

agranulocytosis, leukopenia. Their simultaneous use with sulfonamides should be avoided.
Hexamethylenetetramine (urotropine), high doses ascorbic acid, diuretics - an increased risk of developing crystalluria. Combined use is not recommended.
Erythromycin, lincomycin, tetracycline, trimethoprim, pyrimethamine - mutual reinforcement antibacterial activity, expanding the spectrum of action. Risk of pancytopenia and megaloblastic anemia when used concomitantly with pyrimethamine (inhibition of folic acid synthesis increases).
Folic acid, bactericidal antibiotics (including penicillins, cephalosporins), rifampicin - the effectiveness of sulfadimidine decreases.
Methotrexate - sulfonamides increase the toxicity of methotrexate.
PASK preparations, barbiturates, local anesthetics(benzocaine, tetracaine, procaine), preparations containing PABA - a decrease in the antimicrobial activity of sulfadimidine. There is an increased risk of developing methemoglobinemia with the simultaneous use of sulfonamides with prilocaine.
Oral estrogen-containing contraceptives - with simultaneous use, their contraceptive action. Should apply additional measures contraception during treatment and within 7 days after stopping treatment with sulfonamides.
Oral typhoid vaccine - sulfonamides as antibacterial drugs inactivate the vaccine. The use of antibacterial drugs should be avoided for 3 days before and after oral vaccination.
Antacids - absorption of sulfadimidine in the intestine is reduced under their influence.
Diagnostic Tests: Sulfonamides can cause false positive result Benedict's test for determining glucose in urine; may interfere with urine urobilinogen test results.

Overdose

Symptoms of drug overdose Sulfadimezin: anorexia, spastic abdominal pain, nausea, vomiting, dizziness, headache, drowsiness, loss of consciousness. Hyperthermia, hematuria, crystalluria are possible. Pathological changes blood (leukopenia, agranulocytosis, hemolytic anemia) and jaundice are later manifestations overdose. Perhaps the development of methemoglobinemia.
Treatment: immediate discontinuation of the drug, gastric lavage, an enhanced regimen of drinking solutions is shown, urine is puffed; decreased diuresis and normal function kidney - intravenous administration solutions. In the future - symptomatic treatment.
When confirming methemoglobinemia, the introduction of 1% methylene blue is indicated.
Peritoneal dialysis is not effective, hemodialysis is only moderately effective in the treatment of sulfonamide overdose.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25º C.
Keep out of the reach of children.

Release form

Sulfadimezin - tablets.
Packing: 10 tablets in a blister.

Compound

1 tablet Sulfadimezin contains sulfadimidine 500 mg.
Excipients: potato starch, gelatin, colloidal silicon dioxide, calcium stearate.

Additionally

Given the similarity chemical structure, sulfonamides should not be used by persons with hypersensitivity to furosemide, thiazide diuretics, carbonic anhydrase inhibitors and sulfonylurea derivatives.
Sulfonamides, including sulfadimidine, are not used to treat infectious diseases caused by group A beta-hemolytic streptococcus, since they do not contribute to its eradication and, therefore, cannot prevent complications such as rheumatism and glomerulonephritis.
Fatal cases associated with the use of sulfonamides were extremely rare, occurred due to serious adverse reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatonecrosis, agranulocytosis, aplastic anemia and others. pathological conditions from the blood system.
Sulfonamides should be discontinued at the first appearance of rashes on the skin and / or mucous membranes or any other signs backlash. AT rare cases after the appearance of a rash on the skin, severe adverse reactions may develop. Patients should be informed about the signs of Stevens-Johnson syndrome and toxic epidermal necrolysis and the need for immediate and final discontinuation of sulfonamide treatment at the first manifestation. Biggest Risk the onset of Stevens-Johnson syndrome and toxic epidermal necrolysis occurs in the first weeks of treatment. top scores in the treatment of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with early diagnosis and immediate discontinuation of the suspected drug. Immediate discontinuation of the drug is associated with best forecast. If a patient develops Stevens-Johnson syndrome or toxic epidermal necrolysis during treatment with sulfonamides, incl. sulfadimidine, any preparations containing sulfonamides should not be repeated by this patient throughout his life.
Hematological disorders also require the immediate cessation of treatment with sulfonamides forever. Rash, sore throat, fever, joint pain, pale skin, purpura, or jaundice may be early signs a serious pathological reaction from the blood system when using sulfonamides, including sulfadimidine.
The risk of pseudomembranous colitis, which can range from mild to life-threatening, exists with virtually all antibacterial agents, including sulfonamides (as a result overgrowth Clostridium difficile). Therefore, it is important to consider the possibility of this complication in patients with diarrhea to determine further treatment tactics.
Sulfonamides, incl. sulfadimidine, should be used with caution in patients with impaired renal function, liver, severe allergic diseases or bronchial asthma, patients with diabetes(sulfonamides can affect blood sugar levels). If possible, sulfonamides should be avoided in patients over 65 years of age due to an increased risk of severe adverse reactions.
During treatment with the drug, especially long-term, it is necessary to systematically monitor the state of kidney function (creatinine clearance), liver (serum transaminase level), picture peripheral blood (general analysis blood, platelets, reticulocytes), blood glucose levels.
Patients need to consume enough fluids to maintain high diuresis (minimum 1200 ml/day) to prevent crystalluria and the development of urolithiasis. For the same purpose, if necessary, sulfadimidine can be prescribed in combination with drugs that alkalinize urine.
It is recommended to avoid exposure to direct sun rays and artificial ultraviolet irradiation, given the possibility of developing photosensitivity reactions when using sulfonamides.
Since sulfonamides are bacteriostatic and not bactericidal drugs, a full course of therapy is necessary to prevent recurrence of infection and development sustainable forms microorganisms.
During treatment, it is necessary to observe the dosing regimen, do not skip doses. If a dose is missed, DO NOT double the next dose.
The ability to influence the reaction rate when driving vehicles or operating other mechanisms.
Until it's clear individual reaction patient on the drug, you should refrain from driving vehicles or other mechanisms, given that during treatment with sulfadimidine such adverse reactions from nervous system like dizziness, convulsions, drowsiness, hallucinations.

main parameters

Name:	SULFADIMESIN
ATX code:	J01EB03 -

Sulfadimezin (powder)

Pharmachologic effect:

Antimicrobial bacteriostatic agent, sulfanilamide. The mechanism of action is associated with competitive antagonism with PABA and inhibition of dihydropteroate synthetase, which leads to a disruption in the synthesis of dihydrofolic acid and, ultimately, its active metabolite, tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Klebsiella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics:

Absorption - fast (mainly in the small intestine). Communication with plasma proteins - 75-86%. It penetrates well into tissues (including lungs, cerebrospinal fluid). Metabolized in the liver by acetylation. T1 / 2 - 7 hours. Excreted by the kidneys by glomerular filtration. Acetylated metabolites may precipitate when concentrated in urine. The solubility of metabolites is improved by alkalinization of urine.

Indications:

Infectious and inflammatory diseases caused by sensitive microflora: pneumonia, gonorrhea, sepsis, dysentery, toxoplasmosis, tonsillitis, bronchitis, sinusitis, otitis media, inflammatory diseases of the biliary and urinary tract, erysipelas, wound infection.

Contraindications:

Hypersensitivity, depression of bone marrow hematopoiesis, chronic renal failure, hyperbilirubinemia in children (risk of developing bilirubin encephalopathy), congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy, lactation.

Dosing regimen:

Inside, 1 g 4-6 times a day. With pneumonia and meningitis at the first appointment - 2 g; children - at the rate of 0.1 g / kg for the first dose, then 0.25 g / kg every 4, 6, 8 hours. Higher doses for adults: single - 2 g, daily - 7 g; for children under 1 year old - 0.15 g / kg, over 1 year old - 0.1-0.15 g / kg. With dysentery, 2 courses of treatment are carried out. The first course: on days 1 and 2 - 1 g every 4 hours (6 g / day in total), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours ( 3 g/day). After 5-6 days, the second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - after 8 hours (total 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day, do not give at night), day 5 - 3 g / day.

Side effects:

Nausea, vomiting, crystalluria, allergic reactions, leukopenia, agranulocytosis.

Special instructions:

Interaction:

Benzocaine, procaine reduce antimicrobial activity (PABA is released during hydrolysis). NSAIDs, hypoglycemic agents (sulfonylurea derivatives), phenytoin and coumarin anticoagulants increase the severity of side effects. Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria. Reduces efficiency bactericidal antibiotics acting only on dividing microorganisms (including penicillins and cephalosporins). Antacids reduce intestinal absorption. With toxoplasmosis, a combination with pyrimethamine is possible. Increases (mutually) hematotoxicity of chloramphenicol, thiamazole.

Sulfadimezin price and availability in pharmacies of the city

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Sulfadimezin - antibacterial sulfanilamide drug.

The composition of Sulfadimezin and the release form

Sulfadimezin is produced in the form of white tablets of a flat-cylindrical form.

One tablet contains the active substance - sulfadimidine 0.5 g.

Auxiliary components: potato starch, stearic acid, talc, polysorbate 80.

In packs of 10 tablets.

pharmachologic effect

Bacteriostatic antimicrobial drug, sulfanilamide. The mechanism of action of Sulfadimezin is due to the inhibition of dihydropteroate synthase, competitive antagonism with para-aminobenzoic acid, impaired synthesis of tetrahydrofolic acid, which is necessary for the synthesis of pyrimidines and purines.

According to the instructions, Sulfadimezin is active against gram-negative and gram-positive cocci., Clostridium perfringens, Escherichia coli, Vibrio cholerae, Corynebacterium diphtheriae, Chlamydia spp., Shigella spp., Bacillus anthracis, Actinomyces israelii, Yersinia pestis, Klebsiella spp.

Sulfadimezin - indications for use

According to the instructions, indications for Sulfadimezin are diseases caused by microorganisms sensitive to it:

• otitis media;
• pneumonia;
• tonsillitis;
• exacerbation chronic bronchitis;
• sinusitis;
• erysipelas;
• inflammatory diseases of the urinary tract;
• shigellosis;
• wound infection;
• inflammatory diseases biliary tract.

Contraindications to the use of Sulfadimezin

The instructions for Sulfadimezin indicate the following contraindications:

• azotemia;
• porphyria;
• inhibition of cerebral hematopoiesis;
• congenital deficiency of glucose-6-phosphate dehydrogenase;
• children's age up to three years;
• pregnancy and breastfeeding;
• chronic renal failure;
• hyperbilirubinemia in children;
• hypersensitivity to one or more components of the drug.

Sulfadimezin is prescribed with caution according to the instructions in the following cases:

• allergic diseases in history;
• liver dysfunction.

Method of application of Sulfadimezin and dosing regimen

According to the instructions, Sulfadimezin is taken orally. The dosage regimen depends on the indications for Sulfadimezin.

With tonsillitis, otitis media, children over three years old, as a rule, take 0.05-0.075 g per kg of body weight, divided into several doses, adults - 1 g twice a day. The duration of admission is one week.

With shigellosis, two courses of therapy are necessary. The first course: 1 g of the drug every four hours on the first and second days of therapy, then on the third and fourth days - 1 g every six hours, on the fifth and sixth day - 1 g every eight hours.

With sinusitis, exacerbation of chronic bronchitis, erysipelas, children take 0.1-0.15 g per kg of body weight per day. Adults are prescribed Sulfadimezin according to indications at a dosage of 1 g per day. Duration of admission - 1-1.5 weeks.

For pneumonia and wound infections, the dosage for children is 0.1 g per kg of body weight for the first time, then the dosage is increased to 0.1-0.15 g per kg of body weight per day. Adults take 2 g for the first time, then the dosage is increased to 1 g per day. Two to three days after the symptoms disappear, Sulfadimezin is discontinued.

In inflammatory diseases of the urinary and biliary tract, the dosage for children is 0.05-0.075 g per kg of body weight per day. Adults take Sulfadimezin according to the instructions for 0.5 g per day. The duration of the drug is 1-1.5 weeks.

The second course is carried out five days after the first course. On the first and second day, take 1 g every four hours, and at night after eight hours. On the third and fourth day - 1 g every four hours, do not take the drug at night. On the fifth day, the drug is 3 g per day.

The maximum single dosage for adults is 2 g, daily - 7 g. For children, the maximum daily dosage is 0.1-0.15 g per kg of body weight.

Side effects of sulfadimezin

According to reviews, Sulfadimezin can cause the following side effects from the side various systems the life of the organism:

• leukopenia;
• crystalluria;
• vomit;
• allergic reactions;
• agranulocytosis;
• nausea.

Drug Interactions Sulfadimesin

Simultaneous use of Sulfadimezin:

• with bactericidal antibiotics reduces their effectiveness;
• with thiamazole, chloramphenicol increases their hepatotoxicity;
• with procaine and benzocaine reduces their antimicrobial activity;
• with methenamine and ascorbic acid increases the risk of developing crystalluria;
• with antacids reduces the absorption of the drug in the intestine;
• with hypoglycemic drugs, NSAIDs, coumarin anticoagulants, phenytoin increases the severity of side effects of the drug.

Storage conditions

The drug Sulfadimezin is stored in a dry, dark, cool place for no longer than five years.

Sincerely,

Dosage forms
tablets 500mg, tablets 0.5g

Manufacturers
Akrikhin KhPK (Russia), Biochemist (Russia), Dalkhimfarm (Russia), Irbit Chemical and Pharmaceutical Plant (Russia), Moskhimfarmpreparaty im. ON THE. Semashko (Russia), Obolensky pharmaceutical enterprise (Russia), Farmadon (Russia), Khabarovsk chemical plant (Russia), Schelkovsky vitamin plant (Russia)

Pharmgroup
Antimicrobial sulfa drugs

International generic name
Sulfadimidine

Vacation order
Released by prescription

Synonyms
Sulfadimidine

Compound
The active substance is sulfadimidine.

pharmachologic effect
Antimicrobial, antibacterial (bacteriostatic). It blocks the acceptance of para-aminobenzoic acid by microorganisms and stops the synthesis of folate (sulfonamides are captured by the microbial cell instead of para-aminobenzoic acid). Rapidly absorbed from the gastrointestinal tract (mainly in the small intestine). It penetrates well into tissues (including the lungs, cerebrospinal fluid), is quickly excreted from the body, the half-life is 7 hours; elimination is carried out mainly by the kidneys by glomerular filtration. It undergoes biotransformation in the liver, acetylated metabolites may precipitate when concentrated in the urine. The solubility of metabolites is improved by alkalinization of urine. It inhibits the reproduction of gram-positive and gram-negative microorganisms, incl. anaerobes.

Indications for use
pneumococcal, meningococcal, streptococcal infections, diseases caused coli: tonsillitis, bronchitis, pneumonia, sinusitis, otitis, meningitis, inflammatory diseases of the bile and urinary tract, wound infection, pyoderma, gonorrhea, trachoma, erysipelas, dysentery, toxoplasmosis.

Contraindications
Hypersensitivity. Restrictions for use: diseases hematopoietic system, impaired renal function, hyperbilirubinemia in children, deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation.

Side effect
Nausea, vomiting, crystalluria, leukopenia, agranulocytosis, allergic reactions.

Interaction
Reduces the effectiveness of bactericidal antibiotics that act only on dividing microorganisms (including penicillins, cephalosporins). With toxoplasmosis, a combination with chloridine is acceptable. Absorption in the intestine is reduced under the influence of antacids. On the background simultaneous reception butadione, sulfonylurea derivatives, diphenin, neodicoumarin, and other agents with high affinity for plasma proteins, it is possible to displace sulfadimidine from its association with proteins and increase the concentration of its free fraction in the blood. High doses of ascorbic acid, hexamethylenetetramine (urotropine) increase the risk of crystal formation. Antimicrobial activity falls in the presence of novocaine, as well as drugs containing para-aminobenzoic acid. Increases (mutually) hematotoxicity of chloramphenicol, mercazolil.

Overdose
No information.

Method of application and dosage
Inside - 1 g 4-6 times a day; with pneumonia and meningitis, 2 g is prescribed for 1 dose; children - at the rate of 0.1 g / kg per dose, then - 0.25 g / kg every 4, 6, 8 hours. Higher doses for adults - single 2 g, daily 7 g; daily dose children under 1 year old - 0.15 g / kg, over 1 year old - 0.1-0.15 g / kg; for dysentery, it is prescribed according to the scheme: 1 cycle of the course of treatment - 25-30 g, 2 cycle - 18-21 g.
special instructions
During treatment, abundant alkaline drink; at long-term use systematic monitoring of the blood test is necessary.

Storage conditions
List B. In a dry, dark place.